ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.33796591
2	piRNA metabolic process (GO:0034587)	4.61874594
3	behavioral response to nicotine (GO:0035095)	4.35879223
4	fucose catabolic process (GO:0019317)	4.11375728
5	L-fucose metabolic process (GO:0042354)	4.11375728
6	L-fucose catabolic process (GO:0042355)	4.11375728
7	multicellular organism reproduction (GO:0032504)	4.04753675
8	DNA methylation involved in gamete generation (GO:0043046)	4.02086739
9	sperm motility (GO:0030317)	4.00894883
10	protein polyglutamylation (GO:0018095)	3.83535880
11	DNA double-strand break processing (GO:0000729)	3.73206330
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.71877164
13	regulation of meiosis I (GO:0060631)	3.67817227
14	acrosome reaction (GO:0007340)	3.64007023
15	DNA deamination (GO:0045006)	3.47538117
16	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.46006551
17	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.44765558
18	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.43578538
19	cilium or flagellum-dependent cell motility (GO:0001539)	3.39978729
20	regulation of mesoderm development (GO:2000380)	3.35745760
21	male meiosis I (GO:0007141)	3.33877440
22	centriole replication (GO:0007099)	3.32540294
23	spermatid development (GO:0007286)	3.28899979
24	indolalkylamine metabolic process (GO:0006586)	3.27930022
25	epithelial cilium movement (GO:0003351)	3.27919135
26	synapsis (GO:0007129)	3.26130824
27	indole-containing compound catabolic process (GO:0042436)	3.20472379
28	indolalkylamine catabolic process (GO:0046218)	3.20472379
29	tryptophan catabolic process (GO:0006569)	3.20472379
30	single strand break repair (GO:0000012)	3.19601306
31	sperm-egg recognition (GO:0035036)	3.18185893
32	rRNA methylation (GO:0031167)	3.17199576
33	histone exchange (GO:0043486)	3.16662729
34	male meiosis (GO:0007140)	3.16075363
35	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.16020958
36	regulation of cilium movement (GO:0003352)	3.07508272
37	rRNA modification (GO:0000154)	3.03977052
38	cellular ketone body metabolic process (GO:0046950)	3.00092060
39	chromatin remodeling at centromere (GO:0031055)	2.99746760
40	replication fork processing (GO:0031297)	2.98678283
41	kidney morphogenesis (GO:0060993)	2.97213773
42	tryptophan metabolic process (GO:0006568)	2.93002799
43	recombinational repair (GO:0000725)	2.91736063
44	double-strand break repair via homologous recombination (GO:0000724)	2.91648943
45	regulation of mitotic spindle checkpoint (GO:1903504)	2.91605696
46	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.91605696
47	negative regulation of telomere maintenance (GO:0032205)	2.89443039
48	retinal cone cell development (GO:0046549)	2.86072417
49	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.83947932
50	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.83947932
51	regulation of translation, ncRNA-mediated (GO:0045974)	2.83947932
52	reproduction (GO:0000003)	2.81919115
53	DNA replication checkpoint (GO:0000076)	2.78781477
54	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.77779070
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.76862602
56	meiotic cell cycle (GO:0051321)	2.76309269
57	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.74896131
58	reciprocal meiotic recombination (GO:0007131)	2.73156262
59	reciprocal DNA recombination (GO:0035825)	2.73156262
60	seminiferous tubule development (GO:0072520)	2.72794120
61	regulation of centriole replication (GO:0046599)	2.72724094
62	CENP-A containing nucleosome assembly (GO:0034080)	2.72440201
63	axoneme assembly (GO:0035082)	2.70043552
64	fusion of sperm to egg plasma membrane (GO:0007342)	2.68485374
65	ketone body metabolic process (GO:1902224)	2.68297148
66	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.67327043
67	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.67327043
68	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.66569739
69	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65250622
70	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65250622
71	NADH dehydrogenase complex assembly (GO:0010257)	2.65250622
72	respiratory chain complex IV assembly (GO:0008535)	2.65231692
73	cilium movement (GO:0003341)	2.65142434
74	platelet dense granule organization (GO:0060155)	2.64942064
75	kynurenine metabolic process (GO:0070189)	2.64145986
76	proteasome assembly (GO:0043248)	2.61461009
77	cell-cell recognition (GO:0009988)	2.61338211
78	protein complex biogenesis (GO:0070271)	2.60215530
79	cullin deneddylation (GO:0010388)	2.58921119
80	meiosis I (GO:0007127)	2.57567581
81	nonmotile primary cilium assembly (GO:0035058)	2.55935222
82	protein deneddylation (GO:0000338)	2.53248607
83	binding of sperm to zona pellucida (GO:0007339)	2.53244238
84	somite development (GO:0061053)	2.52316889
85	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.51796443
86	meiotic chromosome segregation (GO:0045132)	2.51418318
87	indole-containing compound metabolic process (GO:0042430)	2.51363233
88	organic cation transport (GO:0015695)	2.51361998
89	mitochondrial respiratory chain complex assembly (GO:0033108)	2.49579480
90	detection of light stimulus involved in visual perception (GO:0050908)	2.49516115
91	detection of light stimulus involved in sensory perception (GO:0050962)	2.49516115
92	protein-cofactor linkage (GO:0018065)	2.49359693
93	DNA replication-dependent nucleosome assembly (GO:0006335)	2.48678880
94	DNA replication-dependent nucleosome organization (GO:0034723)	2.48678880
95	ncRNA catabolic process (GO:0034661)	2.48378803
96	pseudouridine synthesis (GO:0001522)	2.47495796
97	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.46861643
98	regulation of DNA methylation (GO:0044030)	2.46752144
99	protein K6-linked ubiquitination (GO:0085020)	2.46599922
100	microtubule depolymerization (GO:0007019)	2.45441361

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.00633491
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.39807591
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.23122377
4	VDR_22108803_ChIP-Seq_LS180_Human	3.04264925
5	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.67305467
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.54759496
7	FUS_26573619_Chip-Seq_HEK293_Human	2.45567323
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.41443924
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.26541981
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.24479123
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23063346
12	EWS_26573619_Chip-Seq_HEK293_Human	2.22823430
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.22806981
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14275036
15	P300_19829295_ChIP-Seq_ESCs_Human	2.13608408
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13371276
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.13349263
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.11420087
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09834947
20	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.04286603
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.01277276
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.00596417
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.94280074
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.91626746
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.86465554
26	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.79772059
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.75077061
28	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.70885776
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68421422
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.65838066
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62258570
32	ER_23166858_ChIP-Seq_MCF-7_Human	1.62253388
33	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58976539
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.58976539
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.57656089
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57656089
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.45951540
38	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.45163834
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44585119
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44585119
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44530047
42	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.44526834
43	TP53_22573176_ChIP-Seq_HFKS_Human	1.42174129
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.39770528
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39064513
46	AR_25329375_ChIP-Seq_VCAP_Human	1.37986640
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36313837
48	BCAT_22108803_ChIP-Seq_LS180_Human	1.34978994
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33113120
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.32861487
51	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.31123050
52	STAT3_23295773_ChIP-Seq_U87_Human	1.31001422
53	TCF4_23295773_ChIP-Seq_U87_Human	1.30868067
54	TCF4_22108803_ChIP-Seq_LS180_Human	1.29443071
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28878022
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28871177
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24361410
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24361410
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24344524
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.24079828
61	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.24077705
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23981272
63	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21560204
64	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.19500494
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19058836
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16789280
67	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.16131522
68	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15465804
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.15086819
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14857758
71	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.13194263
72	VDR_23849224_ChIP-Seq_CD4+_Human	1.13170653
73	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.12830457
74	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12289264
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11398796
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10969664
77	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08469444
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07091978
79	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.06376802
80	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.05928758
81	NCOR_22424771_ChIP-Seq_293T_Human	1.05065891
82	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04995629
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.04624500
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03550045
85	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02390225
86	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01355790
87	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00461713
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.00371246
89	AR_20517297_ChIP-Seq_VCAP_Human	1.00368262
90	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00268244
91	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00233628
92	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.98043035
93	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96018126
94	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.95764543
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.93915819
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.93354404
97	ERA_21632823_ChIP-Seq_H3396_Human	0.93257051
98	FOXP3_21729870_ChIP-Seq_TREG_Human	0.92352491
99	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92330737
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.91073017

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.35413724
2	MP0005410_abnormal_fertilization	3.19183422
3	MP0003718_maternal_effect	2.97269993
4	MP0006292_abnormal_olfactory_placode	2.82427950
5	MP0002102_abnormal_ear_morphology	2.47790290
6	MP0003195_calcinosis	2.47123161
7	MP0005551_abnormal_eye_electrophysiolog	2.09912602
8	MP0001968_abnormal_touch/_nociception	2.04192211
9	MP0008058_abnormal_DNA_repair	1.97748250
10	MP0002938_white_spotting	1.90172904
11	MP0006072_abnormal_retinal_apoptosis	1.86437741
12	MP0001929_abnormal_gametogenesis	1.86104946
13	MP0002736_abnormal_nociception_after	1.85137239
14	MP0003787_abnormal_imprinting	1.82484607
15	MP0008872_abnormal_physiological_respon	1.81200223
16	MP0003646_muscle_fatigue	1.75074959
17	MP0003698_abnormal_male_reproductive	1.73985490
18	MP0008875_abnormal_xenobiotic_pharmacok	1.72820411
19	MP0001986_abnormal_taste_sensitivity	1.66308662
20	MP0002254_reproductive_system_inflammat	1.63859801
21	MP0008995_early_reproductive_senescence	1.62950379
22	MP0003119_abnormal_digestive_system	1.62535147
23	MP0001485_abnormal_pinna_reflex	1.60357694
24	MP0002210_abnormal_sex_determination	1.55567010
25	MP0003136_yellow_coat_color	1.55426554
26	MP0003693_abnormal_embryo_hatching	1.53487180
27	MP0009745_abnormal_behavioral_response	1.49994229
28	MP0005253_abnormal_eye_physiology	1.49345814
29	MP0005645_abnormal_hypothalamus_physiol	1.49308631
30	MP0005646_abnormal_pituitary_gland	1.49188589
31	MP0001293_anophthalmia	1.49061445
32	MP0008057_abnormal_DNA_replication	1.46429268
33	MP0001486_abnormal_startle_reflex	1.45401453
34	MP0001984_abnormal_olfaction	1.45178709
35	MP0002234_abnormal_pharynx_morphology	1.43636986
36	MP0003121_genomic_imprinting	1.43573874
37	MP0002138_abnormal_hepatobiliary_system	1.42753692
38	MP0002272_abnormal_nervous_system	1.41566074
39	MP0003890_abnormal_embryonic-extraembry	1.41254618
40	MP0003011_delayed_dark_adaptation	1.40215187
41	MP0002160_abnormal_reproductive_system	1.39945709
42	MP0005084_abnormal_gallbladder_morpholo	1.36684115
43	MP0003567_abnormal_fetal_cardiomyocyte	1.36000721
44	MP0010094_abnormal_chromosome_stability	1.33748735
45	MP0002837_dystrophic_cardiac_calcinosis	1.33242431
46	MP0003937_abnormal_limbs/digits/tail_de	1.33202355
47	MP0001188_hyperpigmentation	1.32607400
48	MP0004133_heterotaxia	1.32490166
49	MP0000631_abnormal_neuroendocrine_gland	1.31799891
50	MP0000653_abnormal_sex_gland	1.28084552
51	MP0009046_muscle_twitch	1.27902420
52	MP0001145_abnormal_male_reproductive	1.25683559
53	MP0000427_abnormal_hair_cycle	1.24309206
54	MP0005377_hearing/vestibular/ear_phenot	1.22994528
55	MP0003878_abnormal_ear_physiology	1.22994528
56	MP0000372_irregular_coat_pigmentation	1.21439117
57	MP0003122_maternal_imprinting	1.17709435
58	MP0004142_abnormal_muscle_tone	1.17497900
59	MP0002735_abnormal_chemical_nociception	1.17242800
60	MP0001529_abnormal_vocalization	1.17080289
61	MP0000049_abnormal_middle_ear	1.13869315
62	MP0003880_abnormal_central_pattern	1.13557703
63	MP0005389_reproductive_system_phenotype	1.12488888
64	MP0002638_abnormal_pupillary_reflex	1.12153596
65	MP0003941_abnormal_skin_development	1.11151057
66	MP0003283_abnormal_digestive_organ	1.06730746
67	MP0005395_other_phenotype	1.05242481
68	MP0003786_premature_aging	1.04779005
69	MP0002557_abnormal_social/conspecific_i	1.04478544
70	MP0008789_abnormal_olfactory_epithelium	1.01611455
71	MP0002161_abnormal_fertility/fecundity	1.01155409
72	MP0002751_abnormal_autonomic_nervous	1.00566389
73	MP0004147_increased_porphyrin_level	0.99925140
74	MP0004885_abnormal_endolymph	0.99588401
75	MP0006276_abnormal_autonomic_nervous	0.98727930
76	MP0000516_abnormal_urinary_system	0.97968480
77	MP0005367_renal/urinary_system_phenotyp	0.97968480
78	MP0004742_abnormal_vestibular_system	0.97686550
79	MP0001501_abnormal_sleep_pattern	0.96939160
80	MP0002733_abnormal_thermal_nociception	0.95637702
81	MP0002572_abnormal_emotion/affect_behav	0.94754244
82	MP0005195_abnormal_posterior_eye	0.90648900
83	MP0003137_abnormal_impulse_conducting	0.90591501
84	MP0001119_abnormal_female_reproductive	0.87285683
85	MP0005379_endocrine/exocrine_gland_phen	0.85615230
86	MP0004043_abnormal_pH_regulation	0.85374201
87	MP0005174_abnormal_tail_pigmentation	0.84929724
88	MP0001286_abnormal_eye_development	0.84166429
89	MP0001324_abnormal_eye_pigmentation	0.83755969
90	MP0002067_abnormal_sensory_capabilities	0.83579355
91	MP0002064_seizures	0.81262899
92	MP0001970_abnormal_pain_threshold	0.79729854
93	MP0002734_abnormal_mechanical_nocicepti	0.79393242
94	MP0001963_abnormal_hearing_physiology	0.77347846
95	MP0001764_abnormal_homeostasis	0.76008173
96	MP0002752_abnormal_somatic_nervous	0.75884984
97	MP0004145_abnormal_muscle_electrophysio	0.75038025
98	MP0002876_abnormal_thyroid_physiology	0.74513636
99	MP0005647_abnormal_sex_gland	0.74385686
100	MP0004215_abnormal_myocardial_fiber	0.73683887

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.81678916
2	True hermaphroditism (HP:0010459)	3.52839277
3	Pancreatic fibrosis (HP:0100732)	3.50537869
4	Abnormality of midbrain morphology (HP:0002418)	3.40302437
5	Molar tooth sign on MRI (HP:0002419)	3.40302437
6	Nephronophthisis (HP:0000090)	3.14424081
7	Type II lissencephaly (HP:0007260)	3.01396120
8	Pendular nystagmus (HP:0012043)	3.00749782
9	Congenital stationary night blindness (HP:0007642)	2.84162369
10	Attenuation of retinal blood vessels (HP:0007843)	2.83505404
11	Colon cancer (HP:0003003)	2.79034540
12	Abolished electroretinogram (ERG) (HP:0000550)	2.77237652
13	Abnormality of the labia minora (HP:0012880)	2.74067020
14	Abnormality of the renal medulla (HP:0100957)	2.61233681
15	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.59383356
16	Bile duct proliferation (HP:0001408)	2.58635329
17	Abnormal biliary tract physiology (HP:0012439)	2.58635329
18	Abnormality of the renal cortex (HP:0011035)	2.53941826
19	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.48960032
20	Chronic hepatic failure (HP:0100626)	2.47335582
21	Bilateral microphthalmos (HP:0007633)	2.45293732
22	Methylmalonic acidemia (HP:0002912)	2.44837816
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.43572975
24	Absent/shortened dynein arms (HP:0200106)	2.43572975
25	Short tibia (HP:0005736)	2.43287662
26	Optic nerve hypoplasia (HP:0000609)	2.39120009
27	Meckel diverticulum (HP:0002245)	2.38967561
28	Abnormality of the ileum (HP:0001549)	2.38293156
29	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.37965464
30	Cerebellar dysplasia (HP:0007033)	2.34579082
31	Inability to walk (HP:0002540)	2.33006719
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.30464599
33	Polydipsia (HP:0001959)	2.30195050
34	Abnormal drinking behavior (HP:0030082)	2.30195050
35	Intestinal atresia (HP:0011100)	2.29517696
36	Progressive inability to walk (HP:0002505)	2.28352241
37	Medial flaring of the eyebrow (HP:0010747)	2.27855157
38	Hyperglycinemia (HP:0002154)	2.27165671
39	Cystic liver disease (HP:0006706)	2.20689198
40	Methylmalonic aciduria (HP:0012120)	2.19622487
41	Anencephaly (HP:0002323)	2.17392109
42	Bony spicule pigmentary retinopathy (HP:0007737)	2.14230416
43	Tubular atrophy (HP:0000092)	2.13661874
44	Septo-optic dysplasia (HP:0100842)	2.13614231
45	Sclerocornea (HP:0000647)	2.11310870
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.09372056
47	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.08154378
48	Abnormality of the pons (HP:0007361)	2.05840413
49	Hypoplasia of the pons (HP:0012110)	2.03917424
50	Lissencephaly (HP:0001339)	2.03814786
51	Decreased central vision (HP:0007663)	1.99822858
52	Polyuria (HP:0000103)	1.98849709
53	Abnormal respiratory epithelium morphology (HP:0012253)	1.98816437
54	Abnormal respiratory motile cilium morphology (HP:0005938)	1.98816437
55	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.97957496
56	Hyperglycinuria (HP:0003108)	1.97042035
57	Male pseudohermaphroditism (HP:0000037)	1.95809377
58	Genital tract atresia (HP:0001827)	1.95714610
59	Supernumerary spleens (HP:0009799)	1.94106381
60	Chromsome breakage (HP:0040012)	1.91204963
61	Neoplasm of the adrenal cortex (HP:0100641)	1.90957072
62	Abnormality of chromosome stability (HP:0003220)	1.89913489
63	Abnormality of serine family amino acid metabolism (HP:0010894)	1.86586451
64	Abnormality of glycine metabolism (HP:0010895)	1.86586451
65	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.86102294
66	Abnormality of alanine metabolism (HP:0010916)	1.86102294
67	Hyperalaninemia (HP:0003348)	1.86102294
68	Hyperventilation (HP:0002883)	1.86017967
69	Vaginal atresia (HP:0000148)	1.85390105
70	3-Methylglutaconic aciduria (HP:0003535)	1.85295161
71	Acute necrotizing encephalopathy (HP:0006965)	1.84242427
72	Severe visual impairment (HP:0001141)	1.83910620
73	Aplasia/Hypoplasia of the patella (HP:0006498)	1.83243226
74	Gaze-evoked nystagmus (HP:0000640)	1.82832825
75	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.82791655
76	Abnormal ciliary motility (HP:0012262)	1.82733040
77	Absent thumb (HP:0009777)	1.82275654
78	Chorioretinal atrophy (HP:0000533)	1.81314560
79	Acute encephalopathy (HP:0006846)	1.80071407
80	Ectopic kidney (HP:0000086)	1.78932208
81	Anophthalmia (HP:0000528)	1.77899746
82	Congenital, generalized hypertrichosis (HP:0004540)	1.77801678
83	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.77746228
84	Decreased circulating renin level (HP:0003351)	1.77523225
85	Increased corneal curvature (HP:0100692)	1.76736758
86	Keratoconus (HP:0000563)	1.76736758
87	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.76107757
88	Small hand (HP:0200055)	1.75134880
89	Birth length less than 3rd percentile (HP:0003561)	1.75104213
90	Dandy-Walker malformation (HP:0001305)	1.74776519
91	Congenital primary aphakia (HP:0007707)	1.73677109
92	Gait imbalance (HP:0002141)	1.73410900
93	Renal cortical cysts (HP:0000803)	1.72820026
94	Increased CSF lactate (HP:0002490)	1.72401388
95	Nephrogenic diabetes insipidus (HP:0009806)	1.71309704
96	Azoospermia (HP:0000027)	1.70896756
97	Abnormality of the preputium (HP:0100587)	1.69953423
98	Triphalangeal thumb (HP:0001199)	1.69937204
99	Sloping forehead (HP:0000340)	1.69599729
100	Postaxial foot polydactyly (HP:0001830)	1.69478960

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.81488160
2	ZAK	3.42327433
3	BMPR1B	3.06031374
4	NUAK1	2.85323724
5	ACVR1B	2.65070104
6	PLK4	2.59483931
7	GRK1	2.50005430
8	MAP4K2	2.49280301
9	ADRBK2	2.45441817
10	WNK3	2.38137945
11	TRIM28	2.38047704
12	TNIK	2.27304227
13	VRK2	2.09629411
14	PINK1	1.96843587
15	INSRR	1.90058456
16	CASK	1.88297786
17	TAF1	1.78315656
18	PNCK	1.70648222
19	TLK1	1.67587222
20	MKNK2	1.63487597
21	WNK4	1.61713919
22	PLK3	1.53317496
23	OXSR1	1.42960172
24	VRK1	1.41909521
25	BUB1	1.34232388
26	CDC7	1.31497950
27	MAP3K4	1.30700526
28	TGFBR1	1.28378148
29	PLK2	1.26529847
30	DYRK2	1.25522004
31	EIF2AK3	1.25292955
32	NEK1	1.24227397
33	MUSK	1.20673255
34	MKNK1	1.19711362
35	MAPK13	1.18633244
36	BRSK2	1.17852152
37	TSSK6	1.16289153
38	STK39	1.04541769
39	MST4	1.02896708
40	TTK	1.02652773
41	STK38L	1.01964307
42	AKT3	1.00787996
43	PLK1	0.97682642
44	NME1	0.97293221
45	TAOK3	0.96237316
46	PRKCG	0.95985454
47	SRPK1	0.95537422
48	TIE1	0.92660242
49	DAPK2	0.91595245
50	CSNK1G1	0.89162364
51	PRKCE	0.84187334
52	WEE1	0.83928870
53	MAPKAPK5	0.81267353
54	BCKDK	0.80642644
55	CSNK1G2	0.79979087
56	STK16	0.76124730
57	STK3	0.73917976
58	FGFR2	0.72336789
59	ADRBK1	0.72024588
60	PBK	0.71915685
61	NEK2	0.70818294
62	CSNK1G3	0.69737394
63	ATR	0.66975167
64	GRK5	0.63152310
65	TXK	0.56977094
66	MAPKAPK3	0.56747419
67	MAPK15	0.56561138
68	NLK	0.54771781
69	CAMK1G	0.54249519
70	BCR	0.53494358
71	CSNK1A1L	0.52968811
72	PAK3	0.51105106
73	CHEK2	0.51101579
74	ATM	0.50856934
75	CAMK2A	0.46985207
76	PASK	0.44467828
77	CAMK1	0.43947893
78	DYRK3	0.43912906
79	PDK2	0.42151591
80	FLT3	0.42029817
81	PRKCI	0.42024865
82	EIF2AK2	0.41952528
83	CAMK1D	0.40493340
84	CDK19	0.39692488
85	MAP2K7	0.38288140
86	PTK2B	0.38205969
87	CSNK1A1	0.36687795
88	PRKACA	0.36354479
89	CDK3	0.35729477
90	EPHA4	0.35289281
91	CSNK1D	0.34938366
92	CDK9	0.32264460
93	CSNK1E	0.31868283
94	PRKCQ	0.31375341
95	MAP2K6	0.31312922
96	PRKCA	0.30588413
97	CSNK2A1	0.30175848
98	DAPK1	0.29538559
99	PRKG1	0.29381273
100	RPS6KA5	0.29075372

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.88275104
2	Phototransduction_Homo sapiens_hsa04744	2.38136424
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.32248888
4	Selenocompound metabolism_Homo sapiens_hsa00450	2.31990437
5	Homologous recombination_Homo sapiens_hsa03440	2.26279577
6	RNA polymerase_Homo sapiens_hsa03020	2.24748519
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.14169677
8	Basal transcription factors_Homo sapiens_hsa03022	2.13729637
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13464724
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.00887983
11	Butanoate metabolism_Homo sapiens_hsa00650	1.99664370
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90976086
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.89825317
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85632526
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.85106494
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84952888
17	RNA degradation_Homo sapiens_hsa03018	1.83421452
18	Protein export_Homo sapiens_hsa03060	1.77352566
19	Propanoate metabolism_Homo sapiens_hsa00640	1.72469383
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.71590995
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.71447226
22	Caffeine metabolism_Homo sapiens_hsa00232	1.66946264
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64407167
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.64066726
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.63352100
26	Nicotine addiction_Homo sapiens_hsa05033	1.59238722
27	Proteasome_Homo sapiens_hsa03050	1.55171846
28	Olfactory transduction_Homo sapiens_hsa04740	1.53596044
29	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49383645
30	Parkinsons disease_Homo sapiens_hsa05012	1.47692149
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.47017409
32	One carbon pool by folate_Homo sapiens_hsa00670	1.44341020
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.43918230
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.38974258
35	Mismatch repair_Homo sapiens_hsa03430	1.30954517
36	RNA transport_Homo sapiens_hsa03013	1.29349825
37	Huntingtons disease_Homo sapiens_hsa05016	1.22544716
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.20539600
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16955664
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.12763163
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.11785923
42	Peroxisome_Homo sapiens_hsa04146	1.11310657
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.08972445
44	Purine metabolism_Homo sapiens_hsa00230	1.07785234
45	DNA replication_Homo sapiens_hsa03030	1.06965315
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.06933492
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.04080967
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03251412
49	Base excision repair_Homo sapiens_hsa03410	1.00758909
50	Taste transduction_Homo sapiens_hsa04742	0.97376730
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.92346427
52	Steroid biosynthesis_Homo sapiens_hsa00100	0.92109957
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88627474
54	Retinol metabolism_Homo sapiens_hsa00830	0.86962308
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86712000
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.84911219
57	Morphine addiction_Homo sapiens_hsa05032	0.83209088
58	Nucleotide excision repair_Homo sapiens_hsa03420	0.83089359
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80123298
60	Ribosome_Homo sapiens_hsa03010	0.78319346
61	Alzheimers disease_Homo sapiens_hsa05010	0.77296212
62	Fatty acid elongation_Homo sapiens_hsa00062	0.76158253
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75937144
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73775735
65	Fatty acid degradation_Homo sapiens_hsa00071	0.73026597
66	Metabolic pathways_Homo sapiens_hsa01100	0.71922935
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70964578
68	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69436369
69	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69304812
70	Regulation of autophagy_Homo sapiens_hsa04140	0.66009128
71	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.64748829
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64699306
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.61103311
74	Serotonergic synapse_Homo sapiens_hsa04726	0.59380342
75	Circadian entrainment_Homo sapiens_hsa04713	0.59349605
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.58685558
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55721033
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55265289
79	Insulin secretion_Homo sapiens_hsa04911	0.54354793
80	ABC transporters_Homo sapiens_hsa02010	0.54081652
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.53866677
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53392440
83	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.50314215
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.50218239
85	GABAergic synapse_Homo sapiens_hsa04727	0.48450398
86	Asthma_Homo sapiens_hsa05310	0.48144564
87	Histidine metabolism_Homo sapiens_hsa00340	0.46629217
88	Cell cycle_Homo sapiens_hsa04110	0.46442788
89	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.45973008
90	Oocyte meiosis_Homo sapiens_hsa04114	0.45699001
91	Spliceosome_Homo sapiens_hsa03040	0.45617178
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45496920
93	Glutathione metabolism_Homo sapiens_hsa00480	0.44613904
94	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.44508498
95	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.43379972
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43240540
97	Calcium signaling pathway_Homo sapiens_hsa04020	0.42125163
98	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.39230539
99	Basal cell carcinoma_Homo sapiens_hsa05217	0.38812940
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.37698950

C10ORF82

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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