ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	secondary metabolite biosynthetic process (GO:0044550)	9.41075528
2	acrosome reaction (GO:0007340)	8.36243546
3	fusion of sperm to egg plasma membrane (GO:0007342)	8.14900051
4	central nervous system myelination (GO:0022010)	7.24263291
5	axon ensheathment in central nervous system (GO:0032291)	7.24263291
6	response to pheromone (GO:0019236)	6.73960699
7	plasma membrane fusion (GO:0045026)	6.17342669
8	sperm motility (GO:0030317)	6.12095174
9	sperm capacitation (GO:0048240)	5.74287293
10	calcium ion-dependent exocytosis (GO:0017156)	5.28912343
11	negative regulation of inclusion body assembly (GO:0090084)	5.21884002
12	microtubule polymerization or depolymerization (GO:0031109)	4.94209802
13	protein polyglutamylation (GO:0018095)	4.86929376
14	melanocyte differentiation (GO:0030318)	4.82599381
15	ketone body metabolic process (GO:1902224)	4.64030685
16	long-chain fatty acid biosynthetic process (GO:0042759)	4.60194565
17	pigment cell differentiation (GO:0050931)	4.59742110
18	chromosome condensation (GO:0030261)	4.47227442
19	phenol-containing compound biosynthetic process (GO:0046189)	4.31283092
20	microtubule depolymerization (GO:0007019)	4.22956086
21	DNA packaging (GO:0006323)	4.21465216
22	spermatid development (GO:0007286)	4.18899532
23	microtubule severing (GO:0051013)	4.17763666
24	myelin maintenance (GO:0043217)	4.08282581
25	developmental pigmentation (GO:0048066)	4.07167183
26	tyrosine metabolic process (GO:0006570)	3.83882201
27	peripheral nervous system development (GO:0007422)	3.81745037
28	response to methylmercury (GO:0051597)	3.75990052
29	cell wall macromolecule metabolic process (GO:0044036)	3.72714867
30	single strand break repair (GO:0000012)	3.70058880
31	sperm-egg recognition (GO:0035036)	3.67232626
32	neuronal ion channel clustering (GO:0045161)	3.63226314
33	binding of sperm to zona pellucida (GO:0007339)	3.58642090
34	regulation of inclusion body assembly (GO:0090083)	3.57750318
35	melanosome organization (GO:0032438)	3.42347508
36	multicellular organism reproduction (GO:0032504)	3.41701151
37	astrocyte differentiation (GO:0048708)	3.40455768
38	male gamete generation (GO:0048232)	3.27849827
39	spermatogenesis (GO:0007283)	3.27664019
40	protein targeting to Golgi (GO:0000042)	3.27167616
41	presynaptic membrane organization (GO:0097090)	3.23629896
42	reproduction (GO:0000003)	3.22600104
43	sexual reproduction (GO:0019953)	3.21830168
44	establishment of protein localization to Golgi (GO:0072600)	3.21372864
45	presynaptic membrane assembly (GO:0097105)	3.19023324
46	pigment granule organization (GO:0048753)	3.18477958
47	dendritic spine organization (GO:0097061)	3.13828559
48	myelination (GO:0042552)	3.10167425
49	cellular ketone body metabolic process (GO:0046950)	3.06060417
50	coenzyme catabolic process (GO:0009109)	3.05984665
51	rRNA methylation (GO:0031167)	3.05720769
52	gamete generation (GO:0007276)	3.03027397
53	axon ensheathment (GO:0008366)	3.00494158
54	ensheathment of neurons (GO:0007272)	3.00494158
55	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.00122286
56	actin filament capping (GO:0051693)	2.99984988
57	multicellular organismal movement (GO:0050879)	2.99360445
58	musculoskeletal movement (GO:0050881)	2.99360445
59	spermatid nucleus differentiation (GO:0007289)	2.96825970
60	proline transport (GO:0015824)	2.93659956
61	neuroepithelial cell differentiation (GO:0060563)	2.91244470
62	cell-cell recognition (GO:0009988)	2.89878053
63	negative regulation of Rho protein signal transduction (GO:0035024)	2.89611208
64	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.89383042
65	oligodendrocyte differentiation (GO:0048709)	2.89133731
66	microtubule nucleation (GO:0007020)	2.87919164
67	protein depolymerization (GO:0051261)	2.86488468
68	amino acid import (GO:0043090)	2.86346717
69	centrosome duplication (GO:0051298)	2.85076861
70	L-amino acid import (GO:0043092)	2.82060079
71	astrocyte development (GO:0014002)	2.80783643
72	alanine transport (GO:0032328)	2.78850641
73	synaptic vesicle exocytosis (GO:0016079)	2.73614535
74	sodium ion export (GO:0071436)	2.71100134
75	regulation of Rab GTPase activity (GO:0032313)	2.68902768
76	positive regulation of Rab GTPase activity (GO:0032851)	2.68902768
77	phosphatidylethanolamine metabolic process (GO:0046337)	2.67189870
78	peptidyl-proline hydroxylation (GO:0019511)	2.66504880
79	locomotory exploration behavior (GO:0035641)	2.65422646
80	synaptic vesicle maturation (GO:0016188)	2.63106388
81	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.61695183
82	negative regulation of actin filament depolymerization (GO:0030835)	2.60906618
83	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.59920579
84	retinal rod cell development (GO:0046548)	2.55659764
85	cyclic nucleotide catabolic process (GO:0009214)	2.54309123
86	germ cell development (GO:0007281)	2.54164220
87	glomerular visceral epithelial cell development (GO:0072015)	2.53631101
88	long-term synaptic potentiation (GO:0060291)	2.51795564
89	chromatin silencing (GO:0006342)	2.48669295
90	membrane assembly (GO:0071709)	2.48407664
91	pigment biosynthetic process (GO:0046148)	2.48044855
92	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.47794753
93	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.45244099
94	regulation of neuronal synaptic plasticity (GO:0048168)	2.44517625
95	glutamate secretion (GO:0014047)	2.42654121
96	glycerol ether metabolic process (GO:0006662)	2.41412182
97	acidic amino acid transport (GO:0015800)	2.40554440
98	rRNA modification (GO:0000154)	2.39997248
99	melanin biosynthetic process (GO:0042438)	11.4118318
100	melanin metabolic process (GO:0006582)	10.3085270

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	2.76369227
2	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.65783902
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.59508192
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.43921790
5	DROSHA_22980978_ChIP-Seq_HELA_Human	2.35077523
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.18758042
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.13857931
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.94279434
9	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84955347
10	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.83164509
11	P300_19829295_ChIP-Seq_ESCs_Human	1.82580595
12	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.79438382
13	SMAD4_21799915_ChIP-Seq_A2780_Human	1.77858188
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.77106312
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.73802387
16	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.73795461
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72398495
18	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.69910343
19	FUS_26573619_Chip-Seq_HEK293_Human	1.69095064
20	* STAT3_23295773_ChIP-Seq_U87_Human	1.66789032
21	MITF_21258399_ChIP-Seq_MELANOMA_Human	1.63879537
22	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.63501583
23	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57371530
24	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.57073910
25	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57068205
26	* CBP_20019798_ChIP-Seq_JUKART_Human	1.57068205
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.48376229
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.48233805
29	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.47419533
30	AR_25329375_ChIP-Seq_VCAP_Human	1.46754975
31	TCF4_23295773_ChIP-Seq_U87_Human	1.46346227
32	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.45995732
33	AHR_22903824_ChIP-Seq_MCF-7_Human	1.44653639
34	TP53_18474530_ChIP-ChIP_U2OS_Human	1.44220795
35	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.42523384
36	REST_21632747_ChIP-Seq_MESCs_Mouse	1.42060928
37	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.41574694
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.40463644
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40463644
40	* SMAD3_21741376_ChIP-Seq_ESCs_Human	1.39573506
41	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39551498
42	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.38492994
43	* SMAD4_21741376_ChIP-Seq_HESCs_Human	1.38218128
44	* CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.36650141
45	CJUN_26792858_Chip-Seq_BT549_Human	1.36567608
46	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.36470034
47	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.35107313
48	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.34744844
49	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.31014485
50	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.30951958
51	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28871632
52	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.27677612
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.23502386
54	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.22350091
55	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21797822
56	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.21793808
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.21452983
58	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.18975662
59	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.17689055
60	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.17467709
61	KDM2B_26808549_Chip-Seq_REH_Human	1.16475270
62	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15706294
63	TAF15_26573619_Chip-Seq_HEK293_Human	1.15217012
64	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.15137360
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.14626475
66	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.14559817
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.12128717
68	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.11547385
69	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.11523762
70	* TBL1_22424771_ChIP-Seq_293T_Human	1.10620718
71	GF1_26923725_Chip-Seq_HPCs_Mouse	1.10499072
72	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09644452
73	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.08677731
74	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.08244127
75	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.07684626
76	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07660079
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07527223
78	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.06524371
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06417322
80	TP53_23651856_ChIP-Seq_MEFs_Mouse	1.05604268
81	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.04402356
82	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.03237981
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02749358
84	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01261996
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00979484
86	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.00306575
87	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.99962056
88	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.99693203
89	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.99588804
90	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.99420166
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.98895313
92	* AR_19668381_ChIP-Seq_PC3_Human	0.98887144
93	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.98732050
94	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.98283897
95	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.98283897
96	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98159625
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.97094339
98	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.96399142
99	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.95645981
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.95605895

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	8.04959609
2	MP0000372_irregular_coat_pigmentation	6.00730391
3	MP0003136_yellow_coat_color	5.69634407
4	MP0005408_hypopigmentation	4.86240053
5	MP0000015_abnormal_ear_pigmentation	4.13912166
6	MP0005410_abnormal_fertilization	3.57094555
7	MP0000569_abnormal_digit_pigmentation	3.30195570
8	MP0005075_abnormal_melanosome_morpholog	3.22532523
9	MP0002095_abnormal_skin_pigmentation	3.11084316
10	MP0004381_abnormal_hair_follicle	2.99278888
11	MP0005174_abnormal_tail_pigmentation	2.84264212
12	MP0000371_diluted_coat_color	2.64469193
13	MP0003878_abnormal_ear_physiology	2.63896957
14	MP0005377_hearing/vestibular/ear_phenot	2.63896957
15	MP0002877_abnormal_melanocyte_morpholog	2.60863737
16	MP0000920_abnormal_myelination	2.21536348
17	MP0004859_abnormal_synaptic_plasticity	2.01311726
18	MP0005257_abnormal_intraocular_pressure	1.94331369
19	MP0005670_abnormal_white_adipose	1.85097042
20	MP0001324_abnormal_eye_pigmentation	1.81209264
21	MP0005248_abnormal_Harderian_gland	1.78171447
22	MP0001486_abnormal_startle_reflex	1.78165610
23	MP0002075_abnormal_coat/hair_pigmentati	1.70795324
24	MP0003690_abnormal_glial_cell	1.62184607
25	MP0005423_abnormal_somatic_nervous	1.61272799
26	MP0002938_white_spotting	1.57945755
27	MP0004885_abnormal_endolymph	1.55477555
28	MP0004270_analgesia	1.55093838
29	MP0002272_abnormal_nervous_system	1.51387287
30	MP0002064_seizures	1.43979919
31	MP0001186_pigmentation_phenotype	1.38206436
32	MP0003698_abnormal_male_reproductive	1.35991073
33	MP0009046_muscle_twitch	1.31373259
34	MP0001485_abnormal_pinna_reflex	1.25209312
35	MP0002229_neurodegeneration	1.25166169
36	MP0008569_lethality_at_weaning	1.20782638
37	MP0005409_darkened_coat_color	1.13057419
38	MP0003635_abnormal_synaptic_transmissio	1.10645576
39	MP0001299_abnormal_eye_distance/	1.06697407
40	MP0001348_abnormal_lacrimal_gland	1.05829370
41	MP0003950_abnormal_plasma_membrane	1.05094235
42	MP0001929_abnormal_gametogenesis	1.04505436
43	MP0000749_muscle_degeneration	0.99985196
44	MP0001984_abnormal_olfaction	0.98112461
45	MP0003634_abnormal_glial_cell	0.98048382
46	MP0002822_catalepsy	0.97737165
47	MP0003172_abnormal_lysosome_physiology	0.97725353
48	MP0009780_abnormal_chondrocyte_physiolo	0.97405704
49	MP0009745_abnormal_behavioral_response	0.96741921
50	MP0001968_abnormal_touch/_nociception	0.95096169
51	MP0003646_muscle_fatigue	0.94988026
52	MP0003632_abnormal_nervous_system	0.92324618
53	MP0002090_abnormal_vision	0.91106928
54	MP0002067_abnormal_sensory_capabilities	0.91052918
55	MP0002734_abnormal_mechanical_nocicepti	0.90350827
56	MP0000955_abnormal_spinal_cord	0.89309160
57	MP0002063_abnormal_learning/memory/cond	0.89027154
58	MP0002735_abnormal_chemical_nociception	0.88156688
59	MP0001963_abnormal_hearing_physiology	0.88112385
60	MP0005551_abnormal_eye_electrophysiolog	0.87586080
61	MP0001905_abnormal_dopamine_level	0.86185372
62	MP0002572_abnormal_emotion/affect_behav	0.80704976
63	MP0005253_abnormal_eye_physiology	0.80293322
64	MP0003880_abnormal_central_pattern	0.76264067
65	MP0002638_abnormal_pupillary_reflex	0.75827121
66	MP0002161_abnormal_fertility/fecundity	0.74025575
67	MP0003633_abnormal_nervous_system	0.73857279
68	MP0003631_nervous_system_phenotype	0.73832937
69	MP0001501_abnormal_sleep_pattern	0.73542869
70	MP0005197_abnormal_uvea_morphology	0.73120223
71	MP0004742_abnormal_vestibular_system	0.73079534
72	MP0001970_abnormal_pain_threshold	0.72092710
73	MP0003879_abnormal_hair_cell	0.71362465
74	MP0004510_myositis	0.71171281
75	MP0004924_abnormal_behavior	0.67727942
76	MP0005386_behavior/neurological_phenoty	0.67727942
77	MP0004142_abnormal_muscle_tone	0.64737219
78	MP0002882_abnormal_neuron_morphology	0.62891908
79	MP0002102_abnormal_ear_morphology	0.60577876
80	MP0002066_abnormal_motor_capabilities/c	0.58949750
81	MP0002557_abnormal_social/conspecific_i	0.58687092
82	MP0004036_abnormal_muscle_relaxation	0.57606916
83	MP0002733_abnormal_thermal_nociception	0.57027392
84	MP0003329_amyloid_beta_deposits	0.55862370
85	MP0003718_maternal_effect	0.53857869
86	MP0000026_abnormal_inner_ear	0.52925543
87	MP0004484_altered_response_of	0.52278525
88	MP0000778_abnormal_nervous_system	0.51127023
89	MP0002752_abnormal_somatic_nervous	0.49019492
90	MP0001440_abnormal_grooming_behavior	0.47954715
91	MP0006138_congestive_heart_failure	0.47820443
92	MP0002177_abnormal_outer_ear	0.46710236
93	MP0003045_fibrosis	0.46426381
94	MP0004811_abnormal_neuron_physiology	0.45692519
95	MP0000534_abnormal_ureter_morphology	0.42691307
96	MP0000747_muscle_weakness	0.40741690
97	MP0001502_abnormal_circadian_rhythm	0.40692854
98	MP0002269_muscular_atrophy	0.38822982
99	MP0000367_abnormal_coat/_hair	0.37811563
100	MP0000681_abnormal_thyroid_gland	0.36670647

Predicted human phenotypes

Rank	Gene Set	Z-score
1	White forelock (HP:0002211)	7.84443939
2	Patchy hypopigmentation of hair (HP:0011365)	7.25006639
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	6.68180818
4	Hypoplasia of the fovea (HP:0007750)	6.68180818
5	Ocular albinism (HP:0001107)	6.36255011
6	Blue irides (HP:0000635)	6.34759009
7	Aplasia/Hypoplasia of the macula (HP:0008059)	6.26194262
8	Aplasia/Hypoplasia affecting the retina (HP:0008061)	5.83053288
9	Abnormality of the fovea (HP:0000493)	5.55500683
10	Iris hypopigmentation (HP:0007730)	5.49257162
11	Abnormal auditory evoked potentials (HP:0006958)	5.41046150
12	Hypoplasia of the iris (HP:0007676)	4.70886306
13	Peripheral hypomyelination (HP:0007182)	4.61153310
14	Congenital sensorineural hearing impairment (HP:0008527)	4.44522312
15	Heterochromia iridis (HP:0001100)	4.32381715
16	Hypopigmentation of the fundus (HP:0007894)	4.18774074
17	Severe visual impairment (HP:0001141)	4.03104132
18	Generalized hypopigmentation (HP:0007513)	3.94101889
19	Albinism (HP:0001022)	3.77020076
20	Upper limb muscle weakness (HP:0003484)	3.70942986
21	Alacrima (HP:0000522)	3.66252100
22	Action tremor (HP:0002345)	3.66009074
23	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.57457242
24	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.57457242
25	Scanning speech (HP:0002168)	3.54111440
26	Bell-shaped thorax (HP:0001591)	3.34934399
27	Cerebral hypomyelination (HP:0006808)	3.34273514
28	Spastic paraparesis (HP:0002313)	3.33464631
29	Premature graying of hair (HP:0002216)	3.22696942
30	Abnormality of the corticospinal tract (HP:0002492)	3.17867496
31	Decreased lacrimation (HP:0000633)	3.15635933
32	Insidious onset (HP:0003587)	2.99592923
33	Termporal pattern (HP:0011008)	2.99592923
34	Decreased motor nerve conduction velocity (HP:0003431)	2.66745619
35	Cerebral inclusion bodies (HP:0100314)	2.53449698
36	Focal motor seizures (HP:0011153)	2.52946810
37	Morphological abnormality of the inner ear (HP:0011390)	2.50532706
38	Dysmetria (HP:0001310)	2.43721796
39	Amblyopia (HP:0000646)	2.43599353
40	Paraparesis (HP:0002385)	2.42850106
41	Cutaneous melanoma (HP:0012056)	2.39358283
42	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.37730674
43	Attenuation of retinal blood vessels (HP:0007843)	2.32074526
44	Myokymia (HP:0002411)	2.29345198
45	Decreased central vision (HP:0007663)	2.28342352
46	Resting tremor (HP:0002322)	2.24349199
47	Freckling (HP:0001480)	2.23509096
48	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.23204345
49	Hand muscle atrophy (HP:0009130)	2.21723860
50	Asymmetric septal hypertrophy (HP:0001670)	2.21150228
51	Bilateral sensorineural hearing impairment (HP:0008619)	2.21131396
52	Tubulointerstitial nephritis (HP:0001970)	2.19678478
53	Postural instability (HP:0002172)	2.18340811
54	Abnormality of the ischium (HP:0003174)	2.14597110
55	Underdeveloped nasal alae (HP:0000430)	2.13686208
56	Neurofibrillary tangles (HP:0002185)	2.13502624
57	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.12364572
58	Hypoplastic ischia (HP:0003175)	2.12162478
59	Stridor (HP:0010307)	2.08384164
60	Generalized hypopigmentation of hair (HP:0011358)	2.07198005
61	Intellectual disability, moderate (HP:0002342)	2.00480523
62	Horizontal nystagmus (HP:0000666)	1.93673123
63	Spastic gait (HP:0002064)	1.93491194
64	Hyperkalemia (HP:0002153)	1.89548541
65	Supranuclear gaze palsy (HP:0000605)	1.89297501
66	Megalencephaly (HP:0001355)	1.85156865
67	Focal seizures (HP:0007359)	1.84304098
68	Submucous cleft hard palate (HP:0000176)	1.82485279
69	Abnormality of macular pigmentation (HP:0008002)	1.81679989
70	Progressive cerebellar ataxia (HP:0002073)	1.81314561
71	Distal upper limb amyotrophy (HP:0007149)	1.79868888
72	Upper limb amyotrophy (HP:0009129)	1.79868888
73	Ulnar claw (HP:0001178)	1.79383423
74	Bony spicule pigmentary retinopathy (HP:0007737)	1.74824813
75	Bowel incontinence (HP:0002607)	1.73070567
76	Onion bulb formation (HP:0003383)	1.70991385
77	Delusions (HP:0000746)	1.67004701
78	Recurrent corneal erosions (HP:0000495)	1.66908100
79	Bradycardia (HP:0001662)	1.65239085
80	Facial cleft (HP:0002006)	1.65114596
81	Male infertility (HP:0003251)	1.63345118
82	CNS hypomyelination (HP:0003429)	1.62575116
83	Chronic hepatic failure (HP:0100626)	1.62560021
84	Enlarged epiphyses (HP:0010580)	1.62420054
85	Synophrys (HP:0000664)	1.61326118
86	Leukodystrophy (HP:0002415)	1.59747765
87	Abnormal large intestine physiology (HP:0012700)	1.57388401
88	Split foot (HP:0001839)	1.56894059
89	Absent epiphyses (HP:0010577)	1.56524142
90	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.56524142
91	Difficulty walking (HP:0002355)	1.53573137
92	Congenital stationary night blindness (HP:0007642)	1.49518865
93	Distal sensory impairment (HP:0002936)	1.49514896
94	Intention tremor (HP:0002080)	1.48796628
95	Abnormality of the epiphysis of the femoral head (HP:0010574)	1.47212875
96	Sensory axonal neuropathy (HP:0003390)	1.45695287
97	Akinesia (HP:0002304)	1.45133331
98	Abnormality of femoral epiphyses (HP:0006499)	1.43955928
99	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.43955928
100	Abnormality of the costochondral junction (HP:0000919)	1.42042521

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	DDR2	4.58399564
2	TESK1	3.70385524
3	MAP3K9	3.24244870
4	PLK4	3.20531884
5	PLK2	3.11081311
6	MARK1	2.97327046
7	PRKD3	2.81707266
8	TRIM28	2.57234590
9	PDK2	2.48020792
10	UHMK1	2.26807016
11	INSRR	2.15129431
12	WEE1	2.05567953
13	MARK3	2.02647073
14	FGFR2	1.97303922
15	SIK3	1.95465168
16	PAK6	1.95170404
17	NTRK3	1.84459871
18	PNCK	1.72570435
19	PBK	1.72404510
20	STK38	1.62641158
21	MAP4K2	1.57400849
22	MAP3K3	1.49428157
23	NEK6	1.47274549
24	MINK1	1.46745625
25	MET	1.43622979
26	TYRO3	1.41545787
27	LIMK1	1.39715111
28	LMTK2	1.34286703
29	NTRK2	1.31146625
30	FER	1.26699261
31	BCR	1.25955037
32	CAMK1G	1.24886459
33	WNK1	1.21774313
34	PTK2B	1.18803136
35	PKN1	1.15777639
36	STK39	1.12175720
37	PRKD1	1.12102334
38	ARAF	1.10198382
39	MST1R	1.07457843
40	PAK3	1.04499383
41	LATS2	1.02894793
42	MAPKAPK5	1.02761354
43	TNIK	0.99238959
44	FRK	0.95156714
45	PDK1	0.94586340
46	BMPR1B	0.92305122
47	CSNK1G2	0.91042309
48	PDPK1	0.90759305
49	CDK7	0.88438265
50	CAMK2B	0.79464653
51	PIK3CG	0.77882595
52	BRSK1	0.76962920
53	PRKCH	0.76292374
54	CDK12	0.72711669
55	CSNK1A1L	0.72426194
56	BRD4	0.72094368
57	MAPK10	0.71355817
58	CAMK2A	0.71156212
59	PRKCG	0.65732520
60	STK38L	0.65717335
61	CSNK1G3	0.65433231
62	DYRK1A	0.64193381
63	CAMK2D	0.64094982
64	EPHA4	0.62780485
65	CASK	0.62094189
66	ROCK2	0.61089491
67	ERBB3	0.60730595
68	KSR2	0.59708926
69	FGFR1	0.58955318
70	CDK5	0.56203454
71	CDK18	0.55465106
72	GSK3A	0.55220035
73	CDK11A	0.55071308
74	BRAF	0.54188577
75	MAP2K1	0.53839671
76	ABL2	0.53594931
77	CSNK1G1	0.51250903
78	NTRK1	0.50943638
79	CAMK2G	0.50729705
80	GRK5	0.50464261
81	PRKG1	0.49759805
82	CCNB1	0.49474636
83	KSR1	0.48287425
84	CDK3	0.46775264
85	CAMK1	0.46497317
86	ROCK1	0.46291087
87	GSK3B	0.42973683
88	SGK494	0.42456370
89	SGK223	0.42456370
90	CDK14	0.41010689
91	CDK15	0.40214804
92	AKT3	0.38730979
93	RPS6KA3	0.38154883
94	PAK1	0.37720861
95	PRKAA2	0.36071059
96	PTK2	0.33879326
97	PHKG1	0.33316023
98	PHKG2	0.33316023
99	SGK1	0.32934325
100	CSNK1D	0.31973065

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.24644699
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.09889393
3	Nicotine addiction_Homo sapiens_hsa05033	2.61726118
4	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.55724926
5	Histidine metabolism_Homo sapiens_hsa00340	2.38824012
6	Olfactory transduction_Homo sapiens_hsa04740	2.28599919
7	Morphine addiction_Homo sapiens_hsa05032	2.24254340
8	Tyrosine metabolism_Homo sapiens_hsa00350	2.15017734
9	beta-Alanine metabolism_Homo sapiens_hsa00410	2.13293821
10	Glutamatergic synapse_Homo sapiens_hsa04724	2.04700159
11	Melanogenesis_Homo sapiens_hsa04916	2.02762080
12	Taste transduction_Homo sapiens_hsa04742	2.00451559
13	Circadian entrainment_Homo sapiens_hsa04713	1.91084859
14	Long-term potentiation_Homo sapiens_hsa04720	1.87753387
15	GABAergic synapse_Homo sapiens_hsa04727	1.84839849
16	Salivary secretion_Homo sapiens_hsa04970	1.81052159
17	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.72524105
18	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.66232507
19	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.65216164
20	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.63434389
21	Calcium signaling pathway_Homo sapiens_hsa04020	1.63247528
22	Arginine and proline metabolism_Homo sapiens_hsa00330	1.60873150
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.54882492
24	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.51208587
25	Oocyte meiosis_Homo sapiens_hsa04114	1.48761282
26	Insulin secretion_Homo sapiens_hsa04911	1.48688410
27	Gastric acid secretion_Homo sapiens_hsa04971	1.48134250
28	Amphetamine addiction_Homo sapiens_hsa05031	1.40502750
29	Cocaine addiction_Homo sapiens_hsa05030	1.37288042
30	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.37071315
31	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.28653055
32	Endocytosis_Homo sapiens_hsa04144	1.28173336
33	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.22456675
34	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.16834366
35	Renin secretion_Homo sapiens_hsa04924	1.13153647
36	cAMP signaling pathway_Homo sapiens_hsa04024	1.08953725
37	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.07252796
38	Estrogen signaling pathway_Homo sapiens_hsa04915	1.02272468
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.01454729
40	Cholinergic synapse_Homo sapiens_hsa04725	1.00600311
41	ABC transporters_Homo sapiens_hsa02010	0.97402024
42	Sphingolipid metabolism_Homo sapiens_hsa00600	0.96105293
43	Dopaminergic synapse_Homo sapiens_hsa04728	0.95552793
44	Fatty acid metabolism_Homo sapiens_hsa01212	0.91887275
45	Bile secretion_Homo sapiens_hsa04976	0.90746384
46	Adherens junction_Homo sapiens_hsa04520	0.89234362
47	Phototransduction_Homo sapiens_hsa04744	0.88817239
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87086010
49	Vibrio cholerae infection_Homo sapiens_hsa05110	0.86562019
50	Circadian rhythm_Homo sapiens_hsa04710	0.85753831
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.84059009
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.83956883
53	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.83867698
54	Mineral absorption_Homo sapiens_hsa04978	0.82408748
55	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.82013235
56	Gap junction_Homo sapiens_hsa04540	0.81484468
57	Prion diseases_Homo sapiens_hsa05020	0.80635129
58	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.80224464
59	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.77884164
60	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.76724934
61	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.72816870
62	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.72701933
63	Propanoate metabolism_Homo sapiens_hsa00640	0.70960191
64	ECM-receptor interaction_Homo sapiens_hsa04512	0.70819767
65	Pancreatic secretion_Homo sapiens_hsa04972	0.70502663
66	Tight junction_Homo sapiens_hsa04530	0.69979112
67	Glioma_Homo sapiens_hsa05214	0.69747732
68	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.69148297
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.67652463
70	Hippo signaling pathway_Homo sapiens_hsa04390	0.67436960
71	Serotonergic synapse_Homo sapiens_hsa04726	0.67177165
72	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66745176
73	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.66369763
74	ErbB signaling pathway_Homo sapiens_hsa04012	0.66251006
75	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.65629529
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65145468
77	Butanoate metabolism_Homo sapiens_hsa00650	0.62948396
78	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.61327338
79	Melanoma_Homo sapiens_hsa05218	0.59820397
80	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.58407268
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57196128
82	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.56221942
83	PPAR signaling pathway_Homo sapiens_hsa03320	0.54090275
84	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.52624226
85	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.51416619
86	Rap1 signaling pathway_Homo sapiens_hsa04015	0.49857118
87	Ras signaling pathway_Homo sapiens_hsa04014	0.48630672
88	Lysine degradation_Homo sapiens_hsa00310	0.47186321
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.43436950
90	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.41005073
91	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.40566305
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.40523852
93	Endometrial cancer_Homo sapiens_hsa05213	0.40496476
94	Prostate cancer_Homo sapiens_hsa05215	0.37448002
95	Folate biosynthesis_Homo sapiens_hsa00790	0.37411773
96	Protein digestion and absorption_Homo sapiens_hsa04974	0.37318498
97	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35944357
98	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.35838105
99	Axon guidance_Homo sapiens_hsa04360	0.35386593
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35198502

C10ORF90

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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