ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axonemal dynein complex assembly (GO:0070286)	6.56939279
2	cilium or flagellum-dependent cell motility (GO:0001539)	5.71750700
3	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	5.48166766
4	cilium movement (GO:0003341)	5.24741627
5	epithelial cilium movement (GO:0003351)	5.11537512
6	axoneme assembly (GO:0035082)	4.92016524
7	DNA deamination (GO:0045006)	4.68565716
8	respiratory chain complex IV assembly (GO:0008535)	4.67095823
9	motile cilium assembly (GO:0044458)	4.52162488
10	cytochrome complex assembly (GO:0017004)	4.28506996
11	water-soluble vitamin biosynthetic process (GO:0042364)	3.96870448
12	peptidyl-histidine modification (GO:0018202)	3.86680993
13	protein complex biogenesis (GO:0070271)	3.81274778
14	rRNA modification (GO:0000154)	3.79718841
15	mitochondrial respiratory chain complex assembly (GO:0033108)	3.67074179
16	mannosylation (GO:0097502)	3.61808293
17	preassembly of GPI anchor in ER membrane (GO:0016254)	3.57547747
18	proteasome assembly (GO:0043248)	3.46700572
19	regulation of cilium movement (GO:0003352)	3.43534590
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.36269809
21	aggressive behavior (GO:0002118)	3.35101512
22	pseudouridine synthesis (GO:0001522)	3.34367132
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.25186693
24	GPI anchor biosynthetic process (GO:0006506)	3.22652421
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22390899
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22390899
27	NADH dehydrogenase complex assembly (GO:0010257)	3.22390899
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.18220097
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.18220097
30	rRNA methylation (GO:0031167)	3.16388802
31	aldehyde catabolic process (GO:0046185)	3.14037843
32	lactate metabolic process (GO:0006089)	3.12773478
33	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.11141746
34	GPI anchor metabolic process (GO:0006505)	3.09256871
35	base-excision repair, AP site formation (GO:0006285)	3.08919723
36	positive regulation of prostaglandin secretion (GO:0032308)	3.06821043
37	regulation of mitochondrial translation (GO:0070129)	3.05321637
38	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.99616072
39	electron transport chain (GO:0022900)	2.95833246
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.95630678
41	regulation of hexokinase activity (GO:1903299)	2.93874490
42	regulation of glucokinase activity (GO:0033131)	2.93874490
43	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.93288237
44	termination of RNA polymerase III transcription (GO:0006386)	2.93288237
45	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.93182884
46	ATP synthesis coupled proton transport (GO:0015986)	2.93182884
47	protein localization to cilium (GO:0061512)	2.89831868
48	respiratory electron transport chain (GO:0022904)	2.89771303
49	cullin deneddylation (GO:0010388)	2.85609617
50	metallo-sulfur cluster assembly (GO:0031163)	2.85357104
51	iron-sulfur cluster assembly (GO:0016226)	2.85357104
52	cellular ketone body metabolic process (GO:0046950)	2.84592148
53	intraciliary transport (GO:0042073)	2.84401470
54	C-terminal protein lipidation (GO:0006501)	2.81683924
55	ubiquinone biosynthetic process (GO:0006744)	2.81048661
56	piRNA metabolic process (GO:0034587)	2.80966853
57	cilium organization (GO:0044782)	2.77309482
58	branched-chain amino acid catabolic process (GO:0009083)	2.77125544
59	protein deneddylation (GO:0000338)	2.72495813
60	regulation of cellular amino acid metabolic process (GO:0006521)	2.69053014
61	urate metabolic process (GO:0046415)	2.66892009
62	cilium assembly (GO:0042384)	2.65576328
63	centriole assembly (GO:0098534)	2.58721457
64	regulation of B cell apoptotic process (GO:0002902)	2.58428550
65	rRNA catabolic process (GO:0016075)	2.58402510
66	glutathione derivative biosynthetic process (GO:1901687)	2.57720454
67	glutathione derivative metabolic process (GO:1901685)	2.57720454
68	maturation of 5.8S rRNA (GO:0000460)	2.57674237
69	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.56196844
70	inositol phosphate dephosphorylation (GO:0046855)	2.56196844
71	primary alcohol catabolic process (GO:0034310)	2.55710229
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.54387691
73	purine nucleotide salvage (GO:0032261)	2.53122453
74	tRNA processing (GO:0008033)	2.52810523
75	left/right pattern formation (GO:0060972)	2.51639518
76	histone H2A acetylation (GO:0043968)	2.51023768
77	pyrimidine nucleotide catabolic process (GO:0006244)	2.50344346
78	inositol phosphate catabolic process (GO:0071545)	2.49656337
79	ketone body metabolic process (GO:1902224)	2.49605284
80	ubiquinone metabolic process (GO:0006743)	2.49547449
81	C-terminal protein amino acid modification (GO:0018410)	2.47712181
82	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.47050489
83	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.46050440
84	positive regulation of histone H3-K4 methylation (GO:0051571)	2.44949031
85	left/right axis specification (GO:0070986)	2.44513991
86	DNA double-strand break processing (GO:0000729)	2.42861349
87	nucleoside diphosphate phosphorylation (GO:0006165)	2.42227922
88	mismatch repair (GO:0006298)	2.41568597
89	mitochondrial DNA replication (GO:0006264)	2.40952822
90	deoxyribonucleotide catabolic process (GO:0009264)	2.40800005
91	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.40376619
92	cilium morphogenesis (GO:0060271)	2.40201462
93	terpenoid biosynthetic process (GO:0016114)	2.40020169
94	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.38421727
95	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.38421727
96	DNA methylation involved in gamete generation (GO:0043046)	2.37674926
97	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.37554941
98	purine-containing compound salvage (GO:0043101)	2.37032811
99	protein targeting to mitochondrion (GO:0006626)	2.36163158
100	chaperone-mediated protein transport (GO:0072321)	2.36087176

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.37463475
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.36871432
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.77085995
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.58411085
5	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.52735013
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.32583393
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.18358225
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.13597643
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.13200772
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.75520873
11	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.64391826
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.60660674
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56391385
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.37907438
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32414625
16	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.26638861
17	VDR_22108803_ChIP-Seq_LS180_Human	2.17728041
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.06633068
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.06163414
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.98792791
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.96031065
22	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.88824364
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.77440064
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.70516412
25	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.69118871
26	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.66546859
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.63418096
28	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.60876592
29	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.60425257
30	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.59444210
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.48522189
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.48522189
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.48430037
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.47796028
35	DCP1A_22483619_ChIP-Seq_HELA_Human	1.46899762
36	AR_20517297_ChIP-Seq_VCAP_Human	1.45445330
37	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.45066312
38	* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43794262
39	EWS_26573619_Chip-Seq_HEK293_Human	1.39983138
40	TP53_22573176_ChIP-Seq_HFKS_Human	1.39039955
41	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.37370210
42	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.37188036
43	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.35376691
44	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.29867126
45	* KDM5A_27292631_Chip-Seq_BREAST_Human	1.27958804
46	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.26069506
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.25952968
48	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25020566
49	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.22537600
50	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.22455979
51	FUS_26573619_Chip-Seq_HEK293_Human	1.21981285
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.20891397
53	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19337543
54	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.16774919
55	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.15387060
56	CIITA_25753668_ChIP-Seq_RAJI_Human	1.14587769
57	TTF2_22483619_ChIP-Seq_HELA_Human	1.14196230
58	ER_23166858_ChIP-Seq_MCF-7_Human	1.14027969
59	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.13477142
60	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13453188
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.12778007
62	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.10355556
63	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.09279777
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07642682
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07642682
66	RBPJ_21746931_ChIP-Seq_IB4_Human	1.07159598
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.05123313
68	PHF8_20622853_ChIP-Seq_HELA_Human	1.03987766
69	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03295117
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.01420851
71	NCOR_22424771_ChIP-Seq_293T_Human	1.01380457
72	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.99788851
73	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99050748
74	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98764565
75	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98447159
76	E2F7_22180533_ChIP-Seq_HELA_Human	0.98011646
77	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.97953740
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96568540
79	ERG_20517297_ChIP-Seq_VCAP_Human	0.96048223
80	GATA3_26560356_Chip-Seq_TH2_Human	0.95592992
81	STAT1_20625510_ChIP-Seq_HELA_Human	0.95511059
82	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94216869
83	P300_27268052_Chip-Seq_Bcells_Human	0.93919874
84	ETV1_20927104_ChIP-Seq_GIST48_Human	0.93224404
85	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.91688450
86	* NANOG_20526341_ChIP-Seq_ESCs_Human	0.91086798
87	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90895697
88	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89457705
89	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.89406760
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.88880452
91	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.86604508
92	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.86510291
93	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.86018376
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.85810219
95	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.84889642
96	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84383478
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.84217445
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.83735226
99	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.83005162
100	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.82766603

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	3.10710591
2	MP0008877_abnormal_DNA_methylation	3.09930769
3	MP0003195_calcinosis	3.09638403
4	MP0008058_abnormal_DNA_repair	2.93724219
5	MP0002837_dystrophic_cardiac_calcinosis	2.68738809
6	MP0005645_abnormal_hypothalamus_physiol	2.64135164
7	MP0003786_premature_aging	2.39613378
8	MP0003787_abnormal_imprinting	2.35791871
9	MP0006036_abnormal_mitochondrial_physio	2.35113590
10	MP0002132_abnormal_respiratory_system	2.32846302
11	MP0003718_maternal_effect	2.28760815
12	MP0008995_early_reproductive_senescence	2.28390933
13	MP0004043_abnormal_pH_regulation	2.25928738
14	MP0003806_abnormal_nucleotide_metabolis	2.15241581
15	MP0005646_abnormal_pituitary_gland	2.13767705
16	MP0002909_abnormal_adrenal_gland	2.05601171
17	MP0005379_endocrine/exocrine_gland_phen	2.02864858
18	MP0002653_abnormal_ependyma_morphology	1.98859173
19	MP0002277_abnormal_respiratory_mucosa	1.98696911
20	MP0004147_increased_porphyrin_level	1.93118787
21	MP0006072_abnormal_retinal_apoptosis	1.92986662
22	MP0002163_abnormal_gland_morphology	1.91427218
23	MP0001984_abnormal_olfaction	1.89895645
24	MP0008872_abnormal_physiological_respon	1.88536503
25	MP0006035_abnormal_mitochondrial_morpho	1.71492334
26	MP0005220_abnormal_exocrine_pancreas	1.67092617
27	MP0005084_abnormal_gallbladder_morpholo	1.64004895
28	MP0005075_abnormal_melanosome_morpholog	1.60915439
29	MP0005636_abnormal_mineral_homeostasis	1.60134899
30	MP0001764_abnormal_homeostasis	1.58353062
31	MP0002693_abnormal_pancreas_physiology	1.54647195
32	MP0002160_abnormal_reproductive_system	1.48784681
33	MP0002876_abnormal_thyroid_physiology	1.48134916
34	MP0004133_heterotaxia	1.47065086
35	MP0001986_abnormal_taste_sensitivity	1.42831994
36	MP0005083_abnormal_biliary_tract	1.41658626
37	MP0003186_abnormal_redox_activity	1.39829992
38	MP0005551_abnormal_eye_electrophysiolog	1.39554517
39	MP0002139_abnormal_hepatobiliary_system	1.39443986
40	MP0005389_reproductive_system_phenotype	1.38662686
41	MP0010094_abnormal_chromosome_stability	1.34441015
42	MP0005253_abnormal_eye_physiology	1.33463099
43	MP0000372_irregular_coat_pigmentation	1.31302525
44	MP0005332_abnormal_amino_acid	1.30959140
45	MP0009046_muscle_twitch	1.30661037
46	MP0002102_abnormal_ear_morphology	1.27444656
47	MP0001929_abnormal_gametogenesis	1.26272860
48	MP0006292_abnormal_olfactory_placode	1.23819004
49	MP0001944_abnormal_pancreas_morphology	1.23277097
50	MP0009697_abnormal_copulation	1.21351523
51	MP0008007_abnormal_cellular_replicative	1.18793871
52	MP0001968_abnormal_touch/_nociception	1.11278031
53	MP0003693_abnormal_embryo_hatching	1.10664247
54	MP0004019_abnormal_vitamin_homeostasis	1.10103524
55	MP0008057_abnormal_DNA_replication	1.10089952
56	MP0005410_abnormal_fertilization	1.09808294
57	MP0009780_abnormal_chondrocyte_physiolo	1.08178905
58	MP0001765_abnormal_ion_homeostasis	1.07698702
59	MP0001905_abnormal_dopamine_level	1.06847545
60	MP0003656_abnormal_erythrocyte_physiolo	1.03648883
61	MP0005395_other_phenotype	1.03541850
62	MP0002138_abnormal_hepatobiliary_system	1.03270767
63	MP0000013_abnormal_adipose_tissue	1.02433610
64	MP0003011_delayed_dark_adaptation	0.99476241
65	MP0002638_abnormal_pupillary_reflex	0.98528713
66	MP0009643_abnormal_urine_homeostasis	0.97462903
67	MP0001919_abnormal_reproductive_system	0.96528038
68	MP0000631_abnormal_neuroendocrine_gland	0.95355203
69	MP0008789_abnormal_olfactory_epithelium	0.94413945
70	MP0000653_abnormal_sex_gland	0.92556805
71	MP0010386_abnormal_urinary_bladder	0.91548154
72	MP0003698_abnormal_male_reproductive	0.91428950
73	MP0000516_abnormal_urinary_system	0.90351769
74	MP0005367_renal/urinary_system_phenotyp	0.90351769
75	MP0001145_abnormal_male_reproductive	0.87340313
76	MP0001661_extended_life_span	0.86139741
77	MP0003121_genomic_imprinting	0.86043709
78	MP0005085_abnormal_gallbladder_physiolo	0.85568694
79	MP0002928_abnormal_bile_duct	0.81624874
80	MP0000358_abnormal_cell_content/	0.80297810
81	MP0005365_abnormal_bile_salt	0.80169085
82	MP0002210_abnormal_sex_determination	0.79837629
83	MP0000639_abnormal_adrenal_gland	0.79699882
84	MP0002736_abnormal_nociception_after	0.78751408
85	MP0010234_abnormal_vibrissa_follicle	0.78362579
86	MP0000465_gastrointestinal_hemorrhage	0.77889507
87	MP0001545_abnormal_hematopoietic_system	0.77791792
88	MP0005397_hematopoietic_system_phenotyp	0.77791792
89	MP0002078_abnormal_glucose_homeostasis	0.77157860
90	MP0003252_abnormal_bile_duct	0.75667921
91	MP0003111_abnormal_nucleus_morphology	0.75189983
92	MP0010329_abnormal_lipoprotein_level	0.73973003
93	MP0004957_abnormal_blastocyst_morpholog	0.73360597
94	MP0001756_abnormal_urination	0.72281298
95	MP0002019_abnormal_tumor_incidence	0.71706447
96	MP0004142_abnormal_muscle_tone	0.70551532
97	MP0008961_abnormal_basal_metabolism	0.70266606
98	MP0008873_increased_physiological_sensi	0.70224472
99	MP0000613_abnormal_salivary_gland	0.70210296
100	MP0001835_abnormal_antigen_presentation	0.65866071

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.90783122
2	Absent/shortened dynein arms (HP:0200106)	5.42476401
3	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.42476401
4	Abnormal respiratory epithelium morphology (HP:0012253)	5.37415334
5	Abnormal respiratory motile cilium morphology (HP:0005938)	5.37415334
6	Abnormal respiratory motile cilium physiology (HP:0012261)	5.13596715
7	Abnormal ciliary motility (HP:0012262)	4.93962433
8	Rhinitis (HP:0012384)	4.61812681
9	Chronic bronchitis (HP:0004469)	3.85931734
10	Bronchiectasis (HP:0002110)	3.81447231
11	Pancreatic cysts (HP:0001737)	3.62819859
12	Pancreatic fibrosis (HP:0100732)	3.46614155
13	Acute necrotizing encephalopathy (HP:0006965)	3.15616896
14	Mitochondrial inheritance (HP:0001427)	3.11130282
15	Hepatic necrosis (HP:0002605)	3.05494616
16	Hepatocellular necrosis (HP:0001404)	3.02275224
17	Increased CSF lactate (HP:0002490)	2.94632115
18	Methylmalonic acidemia (HP:0002912)	2.92569635
19	True hermaphroditism (HP:0010459)	2.91943546
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.91604254
21	Abnormality of midbrain morphology (HP:0002418)	2.89941924
22	Molar tooth sign on MRI (HP:0002419)	2.89941924
23	Progressive macrocephaly (HP:0004481)	2.87801019
24	Acute encephalopathy (HP:0006846)	2.86858096
25	Nephronophthisis (HP:0000090)	2.81242147
26	Hypothermia (HP:0002045)	2.57339454
27	Type I transferrin isoform profile (HP:0003642)	2.56584883
28	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.55984919
29	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.55984919
30	Methylmalonic aciduria (HP:0012120)	2.54055829
31	Medial flaring of the eyebrow (HP:0010747)	2.53453573
32	3-Methylglutaconic aciduria (HP:0003535)	2.52001019
33	Recurrent sinusitis (HP:0011108)	2.46698017
34	Ketoacidosis (HP:0001993)	2.45253230
35	Abnormal rod and cone electroretinograms (HP:0008323)	2.41121291
36	Cystic liver disease (HP:0006706)	2.41027097
37	Lipid accumulation in hepatocytes (HP:0006561)	2.40227836
38	Increased hepatocellular lipid droplets (HP:0006565)	2.37355210
39	Hypoglycemic seizures (HP:0002173)	2.28768800
40	Abnormality of the renal medulla (HP:0100957)	2.27292566
41	Increased serum lactate (HP:0002151)	2.23607067
42	Hyperinsulinemic hypoglycemia (HP:0000825)	2.23402170
43	Abolished electroretinogram (ERG) (HP:0000550)	2.22814591
44	Abnormal protein glycosylation (HP:0012346)	2.22664897
45	Abnormal glycosylation (HP:0012345)	2.22664897
46	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.22664897
47	Abnormal protein N-linked glycosylation (HP:0012347)	2.22664897
48	Hypoglycemic coma (HP:0001325)	2.22141876
49	Nasal polyposis (HP:0100582)	2.21569956
50	Cerebral edema (HP:0002181)	2.20994001
51	Infertility (HP:0000789)	2.19165792
52	Abnormality of the renal cortex (HP:0011035)	2.16134106
53	Lactic acidosis (HP:0003128)	2.15178110
54	Chronic sinusitis (HP:0011109)	2.13884868
55	Bronchitis (HP:0012387)	2.13449184
56	Tubulointerstitial nephritis (HP:0001970)	2.13240499
57	Abnormality of vitamin B metabolism (HP:0004340)	2.13009491
58	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.12160298
59	Dicarboxylic aciduria (HP:0003215)	2.12160298
60	Ketosis (HP:0001946)	2.07396561
61	Respiratory failure (HP:0002878)	2.04060373
62	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.03480250
63	Increased intramyocellular lipid droplets (HP:0012240)	2.02362850
64	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.01212425
65	Congenital hepatic fibrosis (HP:0002612)	2.00225949
66	Occipital encephalocele (HP:0002085)	1.99729095
67	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.98584559
68	Large for gestational age (HP:0001520)	1.97624813
69	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95347261
70	Abnormal biliary tract physiology (HP:0012439)	1.95072431
71	Bile duct proliferation (HP:0001408)	1.95072431
72	Tongue fasciculations (HP:0001308)	1.93805839
73	Attenuation of retinal blood vessels (HP:0007843)	1.93165034
74	Congenital primary aphakia (HP:0007707)	1.91371146
75	Congenital stationary night blindness (HP:0007642)	1.91247720
76	Renal Fanconi syndrome (HP:0001994)	1.91071995
77	Decreased central vision (HP:0007663)	1.90432489
78	Lethargy (HP:0001254)	1.90172721
79	Asplenia (HP:0001746)	1.88492792
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.87795549
81	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.86752951
82	Abnormality of methionine metabolism (HP:0010901)	1.84434110
83	Nephrogenic diabetes insipidus (HP:0009806)	1.80829067
84	Male pseudohermaphroditism (HP:0000037)	1.80575851
85	Median cleft lip (HP:0000161)	1.80521623
86	Gait imbalance (HP:0002141)	1.80389712
87	Hypomagnesemia (HP:0002917)	1.79785980
88	Postaxial foot polydactyly (HP:0001830)	1.78345521
89	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.77372121
90	Exercise intolerance (HP:0003546)	1.77371161
91	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.76887709
92	Constricted visual fields (HP:0001133)	1.76830623
93	Increased muscle lipid content (HP:0009058)	1.75895796
94	Neoplasm of the adrenal gland (HP:0100631)	1.73792621
95	Furrowed tongue (HP:0000221)	1.73371139
96	Chronic otitis media (HP:0000389)	1.72328172
97	Optic disc pallor (HP:0000543)	1.72284052
98	Chronic hepatic failure (HP:0100626)	1.71200610
99	Renal cortical cysts (HP:0000803)	1.70654440
100	Hyperglycinuria (HP:0003108)	1.68992502

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.44985151
2	FRK	4.11480872
3	ZAK	3.50861555
4	VRK2	3.15057604
5	MAP4K2	2.58995472
6	NUAK1	2.57022084
7	TLK1	2.36574752
8	MAPK15	2.32562767
9	TAOK3	2.30456404
10	VRK1	2.04078028
11	GRK1	1.82239784
12	STK16	1.77563199
13	NME1	1.68210599
14	BMPR1B	1.66949998
15	BCKDK	1.66237039
16	ADRBK2	1.56910425
17	MAPKAPK3	1.53399118
18	EIF2AK3	1.51746412
19	ACVR1B	1.49733608
20	WNK3	1.49640398
21	TRIM28	1.43304110
22	PBK	1.38688642
23	EIF2AK1	1.37288413
24	BUB1	1.35141354
25	PLK4	1.21653144
26	MKNK2	1.21236516
27	PLK3	1.20827043
28	CSNK1G3	1.20772213
29	BRSK2	1.20457502
30	WNK4	1.18478584
31	PHKG1	1.17477475
32	PHKG2	1.17477475
33	MKNK1	1.17280253
34	CSNK1G1	1.14949356
35	FES	1.12599922
36	INSRR	1.07246664
37	OXSR1	1.06443385
38	TXK	1.02028005
39	SRPK1	0.98089667
40	TSSK6	0.97222485
41	FER	0.96416572
42	TNK2	0.96291484
43	DAPK1	0.95324844
44	CSNK1G2	0.93551640
45	PINK1	0.90121413
46	TTK	0.89580657
47	RPS6KA5	0.89411856
48	TEC	0.89015678
49	SCYL2	0.87883585
50	MAP3K4	0.86396246
51	PRKCI	0.82846739
52	IKBKB	0.82035052
53	FGFR2	0.81406329
54	ERBB3	0.80381818
55	PASK	0.79272129
56	ATR	0.79165612
57	PIM2	0.78266111
58	PRKCQ	0.77824531
59	KDR	0.76882613
60	MAPKAPK5	0.75005089
61	CSNK1A1L	0.73249447
62	DAPK2	0.72110165
63	MAP2K6	0.71081511
64	CDC7	0.69732681
65	PRKCE	0.68663134
66	NME2	0.68439290
67	TESK2	0.68355909
68	PLK1	0.66943115
69	TNIK	0.63451807
70	ITK	0.62664709
71	PDK2	0.62369198
72	KIT	0.62130002
73	GRK6	0.59060625
74	FLT3	0.58402556
75	ATM	0.58349311
76	MAP4K1	0.58321717
77	MAP3K12	0.56335034
78	TBK1	0.55886151
79	CCNB1	0.55378374
80	PLK2	0.55090704
81	MAPK13	0.54443626
82	STK39	0.53070305
83	MAP2K2	0.51324944
84	AURKA	0.47897634
85	MAP2K7	0.46545695
86	CHEK2	0.45087992
87	CSNK1A1	0.41144636
88	IKBKE	0.40713574
89	CSF1R	0.40574060
90	STK4	0.39711391
91	CSNK2A1	0.39134988
92	CSNK2A2	0.38522646
93	SYK	0.37549372
94	STK38L	0.36080257
95	ADRBK1	0.35831823
96	MAP3K11	0.35633271
97	PRKCA	0.35320732
98	DYRK2	0.35270501
99	TAF1	0.34635880
100	MAPK11	0.33378281

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	2.94609792
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.84201060
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.83780749
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77268261
5	RNA polymerase_Homo sapiens_hsa03020	2.44745944
6	Protein export_Homo sapiens_hsa03060	2.35375132
7	Parkinsons disease_Homo sapiens_hsa05012	2.23812949
8	Homologous recombination_Homo sapiens_hsa03440	2.10089567
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.97064606
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.88427415
11	Huntingtons disease_Homo sapiens_hsa05016	1.87543271
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.85486106
13	Butanoate metabolism_Homo sapiens_hsa00650	1.80697876
14	Fatty acid elongation_Homo sapiens_hsa00062	1.76637064
15	Non-homologous end-joining_Homo sapiens_hsa03450	1.73284628
16	Peroxisome_Homo sapiens_hsa04146	1.70904906
17	Mismatch repair_Homo sapiens_hsa03430	1.69589903
18	One carbon pool by folate_Homo sapiens_hsa00670	1.64700979
19	Propanoate metabolism_Homo sapiens_hsa00640	1.64282936
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.63232975
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.59713155
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.57942254
23	Phototransduction_Homo sapiens_hsa04744	1.56918150
24	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55485383
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.51185314
26	Glutathione metabolism_Homo sapiens_hsa00480	1.50289060
27	Chemical carcinogenesis_Homo sapiens_hsa05204	1.47156219
28	RNA degradation_Homo sapiens_hsa03018	1.45556733
29	Base excision repair_Homo sapiens_hsa03410	1.45143670
30	DNA replication_Homo sapiens_hsa03030	1.42210797
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.42134715
32	Type I diabetes mellitus_Homo sapiens_hsa04940	1.39187651
33	Purine metabolism_Homo sapiens_hsa00230	1.31637967
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29225614
35	Basal transcription factors_Homo sapiens_hsa03022	1.27381437
36	Alzheimers disease_Homo sapiens_hsa05010	1.24423546
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.23101725
38	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22268179
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.20100145
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.15745976
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.13260345
42	Tryptophan metabolism_Homo sapiens_hsa00380	1.12749476
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.12215202
44	beta-Alanine metabolism_Homo sapiens_hsa00410	1.12121142
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.10412153
46	Collecting duct acid secretion_Homo sapiens_hsa04966	1.09272833
47	Nucleotide excision repair_Homo sapiens_hsa03420	1.07614680
48	Primary immunodeficiency_Homo sapiens_hsa05340	1.06068349
49	Retinol metabolism_Homo sapiens_hsa00830	1.04607698
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.04474397
51	Caffeine metabolism_Homo sapiens_hsa00232	1.02894309
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.02594367
53	RNA transport_Homo sapiens_hsa03013	1.01094775
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.95826797
55	Metabolic pathways_Homo sapiens_hsa01100	0.93864443
56	Folate biosynthesis_Homo sapiens_hsa00790	0.92406402
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.91978716
58	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.91425205
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.91417726
60	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89953265
61	Sulfur metabolism_Homo sapiens_hsa00920	0.89771814
62	Fatty acid degradation_Homo sapiens_hsa00071	0.89518095
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.87569141
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.86835076
65	Ribosome_Homo sapiens_hsa03010	0.86569044
66	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85153429
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.84665667
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84661365
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83178060
70	Spliceosome_Homo sapiens_hsa03040	0.82505474
71	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.81960726
72	Asthma_Homo sapiens_hsa05310	0.81610266
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.80401930
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.77111492
75	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.75081835
76	Regulation of autophagy_Homo sapiens_hsa04140	0.72993119
77	Olfactory transduction_Homo sapiens_hsa04740	0.71869650
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71750779
79	Phenylalanine metabolism_Homo sapiens_hsa00360	0.71458006
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.70453392
81	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63069839
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56341011
83	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.55914465
84	Allograft rejection_Homo sapiens_hsa05330	0.55884569
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.54309148
86	Cardiac muscle contraction_Homo sapiens_hsa04260	0.53835253
87	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53417585
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.52807668
89	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52201620
90	Taste transduction_Homo sapiens_hsa04742	0.51725893
91	Histidine metabolism_Homo sapiens_hsa00340	0.49906639
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.47410886
93	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.47295029
94	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.46766979
95	Carbon metabolism_Homo sapiens_hsa01200	0.46552165
96	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.45961496
97	Graft-versus-host disease_Homo sapiens_hsa05332	0.44747725
98	Steroid biosynthesis_Homo sapiens_hsa00100	0.43879536
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.40212427
100	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.39484622

C10ORF95

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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