ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinization (GO:0031424)	8.50675815
2	desmosome organization (GO:0002934)	7.55124131
3	bundle of His cell to Purkinje myocyte communication (GO:0086069)	7.09013389
4	establishment of skin barrier (GO:0061436)	6.52418549
5	positive regulation of respiratory burst (GO:0060267)	6.17679633
6	regulation of water loss via skin (GO:0033561)	6.14110944
7	sulfate transmembrane transport (GO:1902358)	5.82127978
8	multicellular organismal water homeostasis (GO:0050891)	5.43763963
9	intestinal absorption (GO:0050892)	5.37923037
10	regulation of guanylate cyclase activity (GO:0031282)	5.37391644
11	cellular glucuronidation (GO:0052695)	5.12983596
12	keratinocyte differentiation (GO:0030216)	5.10333510
13	glomerular filtration (GO:0003094)	4.99240497
14	renal system process involved in regulation of blood volume (GO:0001977)	4.95312363
15	glucuronate metabolic process (GO:0019585)	4.92187665
16	uronic acid metabolic process (GO:0006063)	4.92187665
17	sulfate transport (GO:0008272)	4.75374682
18	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	4.71188019
19	oligosaccharide biosynthetic process (GO:0009312)	4.64142625
20	regulation of respiratory burst (GO:0060263)	4.63555675
21	renal filtration (GO:0097205)	4.60953342
22	positive regulation of pseudopodium assembly (GO:0031274)	4.60621284
23	epidermal cell differentiation (GO:0009913)	4.54330552
24	flavonoid metabolic process (GO:0009812)	4.47882507
25	water homeostasis (GO:0030104)	4.45835941
26	phosphatidylserine acyl-chain remodeling (GO:0036150)	4.26102156
27	bicarbonate transport (GO:0015701)	4.23954474
28	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	4.21203682
29	endocrine process (GO:0050886)	4.21203682
30	regulation of systemic arterial blood pressure by hormone (GO:0001990)	4.21203682
31	regulation of pseudopodium assembly (GO:0031272)	4.14577523
32	peptide cross-linking (GO:0018149)	4.12129383
33	gap junction assembly (GO:0016264)	4.10675550
34	ethanol oxidation (GO:0006069)	4.10674573
35	bile acid and bile salt transport (GO:0015721)	4.04940901
36	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	4.04469224
37	regulation of vitamin metabolic process (GO:0030656)	3.97555376
38	positive regulation of fatty acid beta-oxidation (GO:0032000)	3.93833675
39	glucocorticoid biosynthetic process (GO:0006704)	3.92902440
40	positive regulation of Cdc42 GTPase activity (GO:0043089)	3.88084943
41	intermediate filament organization (GO:0045109)	3.79353976
42	angiotensin maturation (GO:0002003)	3.75714703
43	positive regulation of guanylate cyclase activity (GO:0031284)	3.74442595
44	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.73180770
45	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.64993008
46	antimicrobial humoral response (GO:0019730)	3.61568986
47	sperm capacitation (GO:0048240)	3.61491304
48	transcytosis (GO:0045056)	3.60097107
49	ventricular cardiac muscle cell action potential (GO:0086005)	3.58610273
50	negative regulation of myotube differentiation (GO:0010832)	3.58281809
51	regulation of systemic arterial blood pressure (GO:0003073)	3.58248449
52	positive regulation of systemic arterial blood pressure (GO:0003084)	3.56799014
53	complement activation, classical pathway (GO:0006958)	3.55769058
54	ethanol metabolic process (GO:0006067)	3.51883154
55	renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)	3.51197837
56	keratinocyte proliferation (GO:0043616)	3.49398591
57	NADH metabolic process (GO:0006734)	3.42846305
58	citrulline biosynthetic process (GO:0019240)	3.41482265
59	regulation of cholesterol homeostasis (GO:2000188)	3.39192283
60	sulfur amino acid catabolic process (GO:0000098)	3.37276820
61	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.32201422
62	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.32201422
63	epoxygenase P450 pathway (GO:0019373)	3.32172898
64	sodium ion homeostasis (GO:0055078)	3.31625375
65	cGMP-mediated signaling (GO:0019934)	3.29392929
66	O-glycan processing (GO:0016266)	3.28086493
67	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.27779342
68	regulation of cellular extravasation (GO:0002691)	3.25382675
69	intestinal epithelial cell development (GO:0060576)	3.24706930
70	maintenance of gastrointestinal epithelium (GO:0030277)	3.23847842
71	regulation of intracellular pH (GO:0051453)	3.22513119
72	regulation of cGMP biosynthetic process (GO:0030826)	3.19255515
73	detection of bacterium (GO:0016045)	3.19136546
74	cellular response to pH (GO:0071467)	3.17061775
75	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.16005021
76	negative regulation of keratinocyte proliferation (GO:0010839)	3.15855733
77	antibacterial humoral response (GO:0019731)	3.15664732
78	urea cycle (GO:0000050)	3.12110864
79	positive regulation of fatty acid oxidation (GO:0046321)	3.11046071
80	nucleoside diphosphate biosynthetic process (GO:0009133)	3.08715026
81	citrulline metabolic process (GO:0000052)	3.07713786
82	labyrinthine layer development (GO:0060711)	3.07033643
83	fat-soluble vitamin biosynthetic process (GO:0042362)	3.06528700
84	GDP-mannose metabolic process (GO:0019673)	3.04529426
85	phosphatidylserine metabolic process (GO:0006658)	3.02818244
86	positive regulation of synaptic transmission, GABAergic (GO:0032230)	3.02320112
87	positive regulation of glycoprotein biosynthetic process (GO:0010560)	2.95854443
88	excretion (GO:0007588)	2.95131543
89	thrombin receptor signaling pathway (GO:0070493)	2.93689607
90	regulation of cellular pH (GO:0030641)	2.92654007
91	epidermis development (GO:0008544)	2.91396362
92	regulation of viral release from host cell (GO:1902186)	2.91274297
93	detection of other organism (GO:0098543)	2.90020877
94	positive regulation of glycoprotein metabolic process (GO:1903020)	2.87400587
95	lipoxygenase pathway (GO:0019372)	2.87155271
96	urea metabolic process (GO:0019627)	2.87062128
97	regulation of pH (GO:0006885)	2.87040888
98	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.84474175
99	one-carbon metabolic process (GO:0006730)	2.84338568
100	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.83311204

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	7.24082701
2	CDX2_20551321_ChIP-Seq_CACO-2_Human	4.89172677
3	SOX2_27498859_Chip-Seq_STOMACH_Mouse	2.84593914
4	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.64332543
5	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.63935026
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.59435116
7	SOX2_20726797_ChIP-Seq_SW620_Human	2.58976962
8	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.57399814
9	P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.46885516
10	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.40524801
11	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.38258045
12	FOXO3_23340844_ChIP-Seq_DLD1_Human	2.31852780
13	GATA6_25053715_ChIP-Seq_YYC3_Human	2.30142799
14	GATA4_25053715_ChIP-Seq_YYC3_Human	2.24084687
15	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.11768443
16	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	2.11121697
17	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.05788729
18	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.04083416
19	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.00357880
20	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.90883104
21	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.89847493
22	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.87837673
23	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.86757506
24	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.83615698
25	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.83441920
26	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.81510687
27	RACK7_27058665_Chip-Seq_MCF-7_Human	1.81094301
28	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.68365377
29	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.64711992
30	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.62507992
31	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.59560908
32	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.57120681
33	LXR_22292898_ChIP-Seq_THP-1_Human	1.56964150
34	KLF5_25053715_ChIP-Seq_YYC3_Human	1.56140005
35	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.55600580
36	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.55434956
37	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.54124601
38	ZNF263_19887448_ChIP-Seq_K562_Human	1.51700655
39	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.47067835
40	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.46586490
41	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.44919295
42	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.44073047
43	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.43423839
44	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.40080266
45	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.35650773
46	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.34844920
47	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.28455178
48	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.27843092
49	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.26401615
50	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.26401615
51	* TP63_22573176_ChIP-Seq_HFKS_Human	1.25149123
52	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.24111514
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21189555
54	CLOCK_20551151_ChIP-Seq_293T_Human	1.17445380
55	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.12939992
56	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.10187326
57	DROSHA_22980978_ChIP-Seq_HELA_Human	1.08105414
58	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.07633677
59	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.07450566
60	GATA1_19941826_ChIP-Seq_K562_Human	1.06347982
61	* CEBPB_22108803_ChIP-Seq_LS180_Human	1.05157672
62	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.04535030
63	CTCF_27219007_Chip-Seq_Bcells_Human	1.04096167
64	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.04051606
65	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.02558326
66	BCOR_27268052_Chip-Seq_Bcells_Human	1.02234913
67	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.02226846
68	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.01971347
69	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.01866804
70	EGR1_19032775_ChIP-ChIP_M12_Human	1.01329948
71	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.99630595
72	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.99514295
73	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.96183662
74	* SA1_27219007_Chip-Seq_Bcells_Human	0.94602395
75	ATF3_27146783_Chip-Seq_COLON_Human	0.94443292
76	* CDX2_22108803_ChIP-Seq_LS180_Human	0.93974546
77	GATA2_19941826_ChIP-Seq_K562_Human	0.93270901
78	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.92209315
79	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.91506643
80	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.90228940
81	* E2F1_20622854_ChIP-Seq_HELA_Human	0.90177982
82	* BCL6_27268052_Chip-Seq_Bcells_Human	0.90119953
83	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.89774150
84	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.89322654
85	RXR_22108803_ChIP-Seq_LS180_Human	0.88045894
86	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.86745032
87	CREB1_26743006_Chip-Seq_LNCaP_Human	0.86333138
88	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.85871516
89	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.83091892
90	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.82987892
91	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.82849284
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.82099052
93	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.81230776
94	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.81148171
95	* TP63_23658742_ChIP-Seq_EP156T_Human	0.79248400
96	CTCF_20526341_ChIP-Seq_ESCs_Human	0.78155669
97	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.77723546
98	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.76684602
99	STAT1_20625510_ChIP-Seq_HELA_Human	0.75723350
100	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.75606342

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010234_abnormal_vibrissa_follicle	7.41656480
2	MP0002796_impaired_skin_barrier	5.72730247
3	MP0002139_abnormal_hepatobiliary_system	4.46090555
4	MP0004043_abnormal_pH_regulation	4.00093135
5	MP0010352_gastrointestinal_tract_polyps	3.33970901
6	MP0004264_abnormal_extraembryonic_tissu	3.31601922
7	MP0005501_abnormal_skin_physiology	3.25361248
8	MP0005275_abnormal_skin_tensile	2.96540629
9	MP0003866_abnormal_defecation	2.61346615
10	MP0009379_abnormal_foot_pigmentation	2.46475138
11	MP0005409_darkened_coat_color	2.43777081
12	MP0000579_abnormal_nail_morphology	2.39295165
13	MP0000467_abnormal_esophagus_morphology	2.24369603
14	MP0010155_abnormal_intestine_physiology	2.21527272
15	MP0005085_abnormal_gallbladder_physiolo	2.19175059
16	MP0001765_abnormal_ion_homeostasis	2.04161601
17	MP0001664_abnormal_digestion	1.99291169
18	MP0010678_abnormal_skin_adnexa	1.94952107
19	MP0001216_abnormal_epidermal_layer	1.93189582
20	MP0002138_abnormal_hepatobiliary_system	1.91556833
21	MP0005360_urolithiasis	1.91203405
22	MP0002098_abnormal_vibrissa_morphology	1.90408513
23	MP0005365_abnormal_bile_salt	1.88153270
24	MP0003453_abnormal_keratinocyte_physiol	1.88110174
25	MP0000477_abnormal_intestine_morphology	1.88063867
26	MP0001663_abnormal_digestive_system	1.85273450
27	MP0004782_abnormal_surfactant_physiolog	1.81565356
28	MP0000490_abnormal_crypts_of	1.77592111
29	MP0003868_abnormal_feces_composition	1.75105074
30	MP0000566_synostosis	1.73586663
31	MP0001873_stomach_inflammation	1.73315611
32	MP0000465_gastrointestinal_hemorrhage	1.72251429
33	MP0003183_abnormal_peptide_metabolism	1.68032167
34	MP0005381_digestive/alimentary_phenotyp	1.62680879
35	MP0001666_abnormal_nutrient_absorption	1.56470334
36	MP0003191_abnormal_cellular_cholesterol	1.53033081
37	MP0004147_increased_porphyrin_level	1.48605116
38	MP0003705_abnormal_hypodermis_morpholog	1.46381821
39	MP0005636_abnormal_mineral_homeostasis	1.43319308
40	MP0004947_skin_inflammation	1.41042985
41	MP0003724_increased_susceptibility_to	1.38751644
42	MP0010771_integument_phenotype	1.38127141
43	MP0000377_abnormal_hair_follicle	1.34323902
44	MP0003941_abnormal_skin_development	1.33140049
45	MP0005166_decreased_susceptibility_to	1.28813653
46	MP0002009_preneoplasia	1.25426310
47	MP0001188_hyperpigmentation	1.20348666
48	MP0002060_abnormal_skin_morphology	1.17879798
49	MP0005670_abnormal_white_adipose	1.17245259
50	MP0000678_abnormal_parathyroid_gland	1.16130265
51	MP0009643_abnormal_urine_homeostasis	1.15010465
52	MP0000762_abnormal_tongue_morphology	1.11108281
53	MP0001756_abnormal_urination	1.10067225
54	MP0004885_abnormal_endolymph	1.03356439
55	MP0004019_abnormal_vitamin_homeostasis	1.02192813
56	MP0000383_abnormal_hair_follicle	0.98697590
57	MP0003303_peritoneal_inflammation	0.97584928
58	MP0009931_abnormal_skin_appearance	0.97573538
59	MP0002136_abnormal_kidney_physiology	0.97088197
60	MP0002166_altered_tumor_susceptibility	0.96064913
61	MP0000462_abnormal_digestive_system	0.93364473
62	MP0009840_abnormal_foam_cell	0.92733620
63	MP0003878_abnormal_ear_physiology	0.92280723
64	MP0005377_hearing/vestibular/ear_phenot	0.92280723
65	MP0005451_abnormal_body_composition	0.86721183
66	MP0000230_abnormal_systemic_arterial	0.82195573
67	MP0002006_tumorigenesis	0.81868356
68	MP0000470_abnormal_stomach_morphology	0.79950371
69	MP0008004_abnormal_stomach_pH	0.79842230
70	MP0009785_altered_susceptibility_to	0.78464945
71	MP0005666_abnormal_adipose_tissue	0.75976631
72	MP0003315_abnormal_perineum_morphology	0.74437839
73	MP0004185_abnormal_adipocyte_glucose	0.70928896
74	MP0000537_abnormal_urethra_morphology	0.70457693
75	MP0009780_abnormal_chondrocyte_physiolo	0.69508253
76	MP0005023_abnormal_wound_healing	0.68672659
77	MP0005025_abnormal_response_to	0.68489782
78	MP0003300_gastrointestinal_ulcer	0.67958234
79	MP0005165_increased_susceptibility_to	0.67506002
80	MP0001485_abnormal_pinna_reflex	0.65444685
81	MP0003252_abnormal_bile_duct	0.64436290
82	MP0000367_abnormal_coat/_hair	0.63729832
83	MP0003566_abnormal_cell_adhesion	0.62042312
84	MP0001191_abnormal_skin_condition	0.58648979
85	MP0002876_abnormal_thyroid_physiology	0.57212213
86	MP0005367_renal/urinary_system_phenotyp	0.57028378
87	MP0000516_abnormal_urinary_system	0.57028378
88	MP0005332_abnormal_amino_acid	0.56265576
89	MP0008875_abnormal_xenobiotic_pharmacok	0.55881769
90	MP0009333_abnormal_splenocyte_physiolog	0.55388631
91	MP0004858_abnormal_nervous_system	0.53226286
92	MP0001790_abnormal_immune_system	0.52718375
93	MP0005387_immune_system_phenotype	0.52718375
94	MP0005319_abnormal_enzyme/_coenzyme	0.52046357
95	MP0005310_abnormal_salivary_gland	0.51695997
96	MP0002118_abnormal_lipid_homeostasis	0.51350597
97	MP0001845_abnormal_inflammatory_respons	0.49953495
98	MP0004484_altered_response_of	0.49860340
99	MP0003045_fibrosis	0.49367430
100	MP0003879_abnormal_hair_cell	0.47768874

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperactive renin-angiotensin system (HP:0000841)	8.76548989
2	Decreased circulating renin level (HP:0003351)	7.20867951
3	Metabolic alkalosis (HP:0200114)	6.33733048
4	Abnormality of nail color (HP:0100643)	6.31671004
5	Abnormality of renin-angiotensin system (HP:0000847)	6.31385053
6	Right ventricular cardiomyopathy (HP:0011663)	5.71544883
7	Palmoplantar hyperkeratosis (HP:0000972)	5.00558429
8	Abnormality of chloride homeostasis (HP:0011422)	4.73601058
9	Palmar hyperkeratosis (HP:0010765)	4.69096292
10	Alkalosis (HP:0001948)	4.53061605
11	Flat acetabular roof (HP:0003180)	4.44130743
12	Oral leukoplakia (HP:0002745)	4.36316309
13	Congenital ichthyosiform erythroderma (HP:0007431)	4.34469613
14	Hyperaldosteronism (HP:0000859)	4.31145073
15	Plantar hyperkeratosis (HP:0007556)	4.20465914
16	Alopecia of scalp (HP:0002293)	4.19697065
17	Increased IgE level (HP:0003212)	4.12013626
18	Hyponatremia (HP:0002902)	3.76591165
19	Pili torti (HP:0003777)	3.39533050
20	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.36691003
21	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.31932197
22	Malnutrition (HP:0004395)	3.30432782
23	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.26526768
24	Erythroderma (HP:0001019)	3.25338784
25	Neonatal short-limb short stature (HP:0008921)	3.19671209
26	Ileus (HP:0002595)	3.17607944
27	Hypokalemia (HP:0002900)	3.13796693
28	Abnormal hair laboratory examination (HP:0003328)	3.11299877
29	Dehydration (HP:0001944)	3.11287840
30	Abnormality of sodium homeostasis (HP:0010931)	3.08179121
31	Hyperkalemia (HP:0002153)	3.06439052
32	Onycholysis (HP:0001806)	3.03492482
33	Abnormality of potassium homeostasis (HP:0011042)	2.94013256
34	Abnormality of small intestinal villus morphology (HP:0011472)	2.93602221
35	Villous atrophy (HP:0011473)	2.93602221
36	Corneal erosion (HP:0200020)	2.93338136
37	Woolly hair (HP:0002224)	2.93313287
38	Abdominal distention (HP:0003270)	2.92330343
39	Hemorrhage of the eye (HP:0011885)	2.80560228
40	Syncope (HP:0001279)	2.78815805
41	Thick nail (HP:0001805)	2.72034809
42	Eczematoid dermatitis (HP:0000976)	2.71487247
43	Erythema (HP:0010783)	2.65414427
44	Abnormality of the distal phalanx of the thumb (HP:0009617)	2.63716412
45	Hypotrichosis (HP:0001006)	2.61981981
46	Intrahepatic cholestasis (HP:0001406)	2.61071286
47	Visceral angiomatosis (HP:0100761)	2.54401548
48	Conjugated hyperbilirubinemia (HP:0002908)	2.52777137
49	Flattened epiphyses (HP:0003071)	2.50922635
50	Palmoplantar keratoderma (HP:0000982)	2.45778648
51	Abnormality of the axillary hair (HP:0100134)	2.43568006
52	Abnormality of secondary sexual hair (HP:0009888)	2.43568006
53	Adrenal overactivity (HP:0002717)	2.36628384
54	Abnormal tarsal ossification (HP:0008369)	2.32995937
55	Hemangiomatosis (HP:0007461)	2.27789813
56	Chronic diarrhea (HP:0002028)	2.27771091
57	Flat capital femoral epiphysis (HP:0003370)	2.25938743
58	Pustule (HP:0200039)	2.25063093
59	Fragile nails (HP:0001808)	2.15881871
60	Amniotic constriction ring (HP:0009775)	2.12731148
61	Abnormality of placental membranes (HP:0011409)	2.12731148
62	Curly hair (HP:0002212)	2.08786747
63	Hypohidrosis (HP:0000966)	2.07611633
64	Systemic lupus erythematosus (HP:0002725)	2.06850831
65	Fat malabsorption (HP:0002630)	2.05557801
66	Spinal cord compression (HP:0002176)	2.02620693
67	Palpitations (HP:0001962)	2.00333414
68	Nail dystrophy (HP:0008404)	1.98651330
69	Gangrene (HP:0100758)	1.98624852
70	Congenital sensorineural hearing impairment (HP:0008527)	1.97844626
71	Sparse eyelashes (HP:0000653)	1.97815773
72	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.94783858
73	Abnormality of the salivary glands (HP:0010286)	1.92738543
74	Lip pit (HP:0100267)	1.92706319
75	Hyperparathyroidism (HP:0000843)	1.92701607
76	Ridged nail (HP:0001807)	1.92426130
77	Hydroxyprolinuria (HP:0003080)	1.88493271
78	Abnormality of proline metabolism (HP:0010907)	1.88493271
79	Blepharitis (HP:0000498)	1.87524895
80	Parakeratosis (HP:0001036)	1.86724412
81	Ventricular fibrillation (HP:0001663)	1.84745938
82	Urticaria (HP:0001025)	1.81247268
83	Abnormal blistering of the skin (HP:0008066)	1.79226585
84	Abnormality of carpal bone ossification (HP:0006257)	1.79031856
85	Thin bony cortex (HP:0002753)	1.78529356
86	Abnormality of vitamin B metabolism (HP:0004340)	1.77309720
87	Neonatal onset (HP:0003623)	1.76096175
88	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.73428570
89	Conjunctival hamartoma (HP:0100780)	1.72588249
90	Abnormal biliary tract morphology (HP:0012440)	1.71884881
91	Hypotension (HP:0002615)	1.71732539
92	Pruritus (HP:0000989)	1.70240647
93	Chronic bronchitis (HP:0004469)	1.67637829
94	Ventricular tachycardia (HP:0004756)	1.66732049
95	Breech presentation (HP:0001623)	1.65603376
96	Hoarse voice (HP:0001609)	1.63597925
97	Focal segmental glomerulosclerosis (HP:0000097)	1.62819332
98	Abnormality of the gastric mucosa (HP:0004295)	1.61723709
99	Hyperammonemia (HP:0001987)	1.61691656
100	Dicarboxylic aciduria (HP:0003215)	1.61603623

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	6.36234867
2	MST1R	5.85170042
3	PIK3CA	5.29787536
4	RIPK1	4.62610875
5	ACVR1B	4.57370522
6	LMTK2	3.76198769
7	ERN1	3.06937000
8	EPHB2	2.99363645
9	MET	2.40597788
10	STK24	2.02526527
11	MAPKAPK3	1.74297192
12	PTK6	1.70763404
13	PRKG2	1.67995398
14	MAP3K2	1.59042808
15	MAP3K10	1.56955558
16	STK39	1.49106819
17	MAP3K12	1.25270781
18	MYLK	1.25256280
19	FER	1.19857160
20	BLK	1.18028470
21	PRPF4B	1.13815642
22	TAOK1	1.09947595
23	DDR2	1.08734483
24	TESK1	1.06831375
25	FGFR3	1.05814424
26	GRK6	1.05418442
27	EPHA3	1.04216094
28	FGFR4	1.02755944
29	MAP2K6	0.99373191
30	TESK2	0.97676480
31	PDK2	0.97566957
32	MAP2K2	0.93253566
33	MAP3K3	0.92785293
34	MST4	0.91788527
35	DMPK	0.89536469
36	OXSR1	0.84989534
37	RIPK4	0.84880925
38	MAP3K1	0.82796306
39	EPHB1	0.81359131
40	MATK	0.80133829
41	PDPK1	0.78326184
42	WNK4	0.75504519
43	PTK2	0.74912594
44	MAP3K6	0.73170849
45	TRIB3	0.71951355
46	ABL2	0.70385705
47	CAMK2D	0.70101563
48	CDC42BPA	0.67946207
49	MAP4K1	0.65755366
50	ERBB2	0.65563046
51	TYK2	0.64090892
52	PRKAA2	0.60466033
53	SMG1	0.58306890
54	TGFBR1	0.55246702
55	MAPKAPK2	0.53533055
56	PDK1	0.46121925
57	MAPK11	0.45894853
58	KSR2	0.45730167
59	MAPK7	0.44954704
60	TBK1	0.43914923
61	ZAP70	0.40505102
62	RPS6KB2	0.39426556
63	MAP2K1	0.38212511
64	SRC	0.37736423
65	CSK	0.36823940
66	GRK5	0.36640999
67	PRKCI	0.34177681
68	PAK4	0.34048479
69	PDGFRA	0.33181190
70	RET	0.32979160
71	PRKACG	0.32654672
72	MAP3K11	0.31537004
73	PRKCA	0.30623308
74	NME1	0.30330938
75	NME2	0.30315731
76	FYN	0.28425712
77	RPS6KA2	0.27485981
78	PRKCD	0.26389753
79	EPHA4	0.26361170
80	BMX	0.26104795
81	LRRK2	0.25359523
82	JAK2	0.24786064
83	NLK	0.24780937
84	PIM2	0.24675373
85	FGR	0.21893139
86	LYN	0.21812316
87	IKBKE	0.21477860
88	BMPR2	0.21151662
89	IKBKB	0.20873727
90	IRAK1	0.20180725
91	WNK1	0.20107977
92	CSNK1A1	0.19946739
93	MAP3K14	0.18496702
94	IGF1R	0.18191973
95	GRK1	0.17865059
96	RPS6KC1	0.17243920
97	RPS6KL1	0.17243920
98	PKN2	0.17110642
99	DYRK1B	0.15426443
100	JAK1	0.13563864

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur metabolism_Homo sapiens_hsa00920	5.08080052
2	Nitrogen metabolism_Homo sapiens_hsa00910	4.00690556
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.82795213
4	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.69818578
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.08376043
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.57611954
7	Fat digestion and absorption_Homo sapiens_hsa04975	2.56920643
8	Mineral absorption_Homo sapiens_hsa04978	2.44657520
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.26693264
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.19460561
11	Caffeine metabolism_Homo sapiens_hsa00232	2.19295149
12	Histidine metabolism_Homo sapiens_hsa00340	2.11287709
13	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.10778916
14	Arginine biosynthesis_Homo sapiens_hsa00220	2.04532924
15	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.82406724
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78807333
17	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.73415638
18	Retinol metabolism_Homo sapiens_hsa00830	1.71840535
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.71807688
20	Pancreatic secretion_Homo sapiens_hsa04972	1.60476404
21	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.60002027
22	Renin-angiotensin system_Homo sapiens_hsa04614	1.59695565
23	Bile secretion_Homo sapiens_hsa04976	1.58290483
24	Fatty acid degradation_Homo sapiens_hsa00071	1.57985516
25	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.56366774
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.54695704
27	PPAR signaling pathway_Homo sapiens_hsa03320	1.49068287
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.48871359
29	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.47041033
30	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.44852058
31	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.43628023
32	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.36238968
33	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.32615357
34	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.23434294
35	Ether lipid metabolism_Homo sapiens_hsa00565	1.17464045
36	Arginine and proline metabolism_Homo sapiens_hsa00330	1.14990958
37	Sulfur relay system_Homo sapiens_hsa04122	1.10052308
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09451181
39	Galactose metabolism_Homo sapiens_hsa00052	0.96779620
40	Protein digestion and absorption_Homo sapiens_hsa04974	0.88098388
41	Other glycan degradation_Homo sapiens_hsa00511	0.87741894
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.87430117
43	Renin secretion_Homo sapiens_hsa04924	0.84893588
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.81628262
45	Glycerolipid metabolism_Homo sapiens_hsa00561	0.78835781
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.76691657
47	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.76592527
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.76175283
49	Sphingolipid metabolism_Homo sapiens_hsa00600	0.73953540
50	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.70888700
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70497912
52	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.69996409
53	Phenylalanine metabolism_Homo sapiens_hsa00360	0.67550187
54	Tight junction_Homo sapiens_hsa04530	0.67511329
55	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.65438443
56	Glutathione metabolism_Homo sapiens_hsa00480	0.60640260
57	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.59465037
58	Asthma_Homo sapiens_hsa05310	0.59398854
59	Tyrosine metabolism_Homo sapiens_hsa00350	0.57628699
60	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.56590135
61	GnRH signaling pathway_Homo sapiens_hsa04912	0.56281687
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.54164900
63	Hepatitis C_Homo sapiens_hsa05160	0.53788555
64	Allograft rejection_Homo sapiens_hsa05330	0.45993879
65	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.42589878
66	Fatty acid metabolism_Homo sapiens_hsa01212	0.41761098
67	Butanoate metabolism_Homo sapiens_hsa00650	0.41500541
68	Pertussis_Homo sapiens_hsa05133	0.39686988
69	Graft-versus-host disease_Homo sapiens_hsa05332	0.39320769
70	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.37062729
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35677755
72	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.35343816
73	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34954625
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.30897481
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.27009460
76	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.25254079
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.23466581
78	Amoebiasis_Homo sapiens_hsa05146	0.23258742
79	Choline metabolism in cancer_Homo sapiens_hsa05231	0.22377723
80	Peroxisome_Homo sapiens_hsa04146	0.21873963
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.21873603
82	Leishmaniasis_Homo sapiens_hsa05140	0.21623486
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.20558227
84	Type I diabetes mellitus_Homo sapiens_hsa04940	0.20439223
85	Carbon metabolism_Homo sapiens_hsa01200	0.20272069
86	Gastric acid secretion_Homo sapiens_hsa04971	0.20254022
87	Propanoate metabolism_Homo sapiens_hsa00640	0.19002875
88	Insulin resistance_Homo sapiens_hsa04931	0.18798169
89	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.18705666
90	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.18356386
91	Salmonella infection_Homo sapiens_hsa05132	0.17935296
92	Influenza A_Homo sapiens_hsa05164	0.17481747
93	Fatty acid elongation_Homo sapiens_hsa00062	0.12936873
94	VEGF signaling pathway_Homo sapiens_hsa04370	0.12511556
95	Metabolic pathways_Homo sapiens_hsa01100	0.09250208
96	Antigen processing and presentation_Homo sapiens_hsa04612	0.08976127
97	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.08711793
98	Tuberculosis_Homo sapiens_hsa05152	0.08450124
99	Bladder cancer_Homo sapiens_hsa05219	0.08449620
100	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.05712271

C10ORF99

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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