C11ORF21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.47471282
2negative regulation of cell killing (GO:0031342)6.47471282
3positive regulation of gamma-delta T cell activation (GO:0046645)6.45676189
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.21567004
5antigen processing and presentation of endogenous antigen (GO:0019883)5.60451910
6neutrophil activation involved in immune response (GO:0002283)5.57439578
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.56852198
8regulation of B cell receptor signaling pathway (GO:0050855)5.17019265
9positive regulation by symbiont of host defense response (GO:0052509)5.01420265
10modulation by symbiont of host defense response (GO:0052031)5.01420265
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.01420265
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.01420265
13positive regulation by organism of defense response of other organism involved in symbiotic interact5.01420265
14modulation by symbiont of host immune response (GO:0052553)5.01420265
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.00786792
16leukocyte aggregation (GO:0070486)4.97527183
17detection of other organism (GO:0098543)4.96750514
18detection of bacterium (GO:0016045)4.92575353
19regulation of gamma-delta T cell activation (GO:0046643)4.58748083
20response to peptidoglycan (GO:0032494)4.57089243
21negative regulation of erythrocyte differentiation (GO:0045647)4.55962297
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.52702241
23cellular extravasation (GO:0045123)4.33990251
24regulation of gamma-delta T cell differentiation (GO:0045586)4.28607040
25negative regulation of lymphocyte mediated immunity (GO:0002707)4.28164803
26negative thymic T cell selection (GO:0045060)4.19408789
27positive regulation of B cell differentiation (GO:0045579)4.19021003
28neutrophil activation (GO:0042119)4.18711745
29macrophage activation involved in immune response (GO:0002281)4.10367868
30negative T cell selection (GO:0043383)4.09074912
31positive thymic T cell selection (GO:0045059)4.02023221
32regulation of B cell differentiation (GO:0045577)4.01214878
33response to interleukin-15 (GO:0070672)3.97457935
34activated T cell proliferation (GO:0050798)3.96627586
35negative regulation of T cell mediated immunity (GO:0002710)3.96107962
36regulation of mast cell degranulation (GO:0043304)3.90827612
37detection of external biotic stimulus (GO:0098581)3.88069239
38B cell receptor signaling pathway (GO:0050853)3.85776454
39negative regulation of leukocyte mediated immunity (GO:0002704)3.85154127
40negative regulation of interleukin-12 production (GO:0032695)3.83475350
41leukocyte migration involved in inflammatory response (GO:0002523)3.80523011
42immunoglobulin mediated immune response (GO:0016064)3.76897358
43positive regulation of granulocyte differentiation (GO:0030854)3.74753589
44granulocyte activation (GO:0036230)3.73809349
45positive regulation of mast cell activation (GO:0033005)3.67816471
46regulation of myeloid leukocyte mediated immunity (GO:0002886)3.64422502
47regulation of mast cell activation involved in immune response (GO:0033006)3.60325090
48myeloid cell activation involved in immune response (GO:0002275)3.59933039
49response to host immune response (GO:0052572)3.59398234
50response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.59398234
51respiratory burst (GO:0045730)3.59159151
52response to muramyl dipeptide (GO:0032495)3.58961198
53negative regulation of phagocytosis (GO:0050765)3.57098189
54microglial cell activation (GO:0001774)3.55940080
55regulation of leukocyte degranulation (GO:0043300)3.51407927
56cellular response to interleukin-15 (GO:0071350)3.50918523
57positive T cell selection (GO:0043368)3.50756341
58T cell selection (GO:0045058)3.50358429
59T cell migration (GO:0072678)3.49154229
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.48791905
61leukocyte degranulation (GO:0043299)3.40910018
62detection of biotic stimulus (GO:0009595)3.40879835
63regulation of tolerance induction (GO:0002643)3.39831827
64regulation of mast cell activation (GO:0033003)3.38203993
65antigen processing and presentation via MHC class Ib (GO:0002475)3.35803378
66regulation of interferon-beta biosynthetic process (GO:0045357)3.35634327
67regulation of T cell tolerance induction (GO:0002664)3.35477158
68thymic T cell selection (GO:0045061)3.32230195
69response to host (GO:0075136)3.30841749
70response to host defenses (GO:0052200)3.30841749
71response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30841749
72regulation of alpha-beta T cell proliferation (GO:0046640)3.28855767
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24059280
74positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.19308047
75neutrophil mediated immunity (GO:0002446)3.18841888
76tolerance induction (GO:0002507)3.14592423
77detection of molecule of bacterial origin (GO:0032490)3.13278364
78positive regulation of mast cell degranulation (GO:0043306)3.11796154
79positive regulation of mast cell activation involved in immune response (GO:0033008)3.11796154
80regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.10911560
81regulation of natural killer cell mediated immunity (GO:0002715)3.10911560
82macrophage activation (GO:0042116)3.10727731
83defense response to protozoan (GO:0042832)3.08384455
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04839172
85positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.04275307
86B cell mediated immunity (GO:0019724)3.03428773
87negative regulation of innate immune response (GO:0045824)3.02952337
88regulation of regulated secretory pathway (GO:1903305)3.00724660
89cellular response to type I interferon (GO:0071357)3.00312506
90type I interferon signaling pathway (GO:0060337)3.00312506
91response to type I interferon (GO:0034340)3.00154395
92megakaryocyte development (GO:0035855)2.98454696
93regulation of granulocyte differentiation (GO:0030852)2.96451185
94regulation of T cell mediated cytotoxicity (GO:0001914)2.93111938
95germinal center formation (GO:0002467)2.92553151
96negative regulation of T-helper cell differentiation (GO:0045623)2.92153417
97negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.92153417
98negative regulation of interleukin-6 production (GO:0032715)2.90794527
99positive regulation of tolerance induction (GO:0002645)2.90716010
100negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.89028371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.49726104
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.09713521
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.05947122
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.92518010
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.66510625
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.49686268
7SCL_19346495_ChIP-Seq_HPC-7_Human3.24768790
8VDR_21846776_ChIP-Seq_THP-1_Human3.12558473
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.07751518
10RUNX_20019798_ChIP-Seq_JUKART_Human2.98403968
11VDR_24763502_ChIP-Seq_THP-1_Human2.87170742
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.84207700
13SPI1_23547873_ChIP-Seq_NB4_Human2.78526431
14MYB_26560356_Chip-Seq_TH2_Human2.71664043
15MYC_22102868_ChIP-Seq_BL_Human2.70471795
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.69378707
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.68742534
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66312624
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65965893
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65413462
21MAF_26560356_Chip-Seq_TH1_Human2.58073436
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56486344
23SPI1_23127762_ChIP-Seq_K562_Human2.52156219
24STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48760358
25UTX_26944678_Chip-Seq_JUKART_Human2.46105641
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44485442
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.42976329
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.33680693
29MYB_26560356_Chip-Seq_TH1_Human2.33191602
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29200905
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.19850008
32TCF7_22412390_ChIP-Seq_EML_Mouse2.17274273
33BRD4_27068464_Chip-Seq_AML-cells_Mouse2.15119910
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.13435560
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96277856
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.96226828
37MAF_26560356_Chip-Seq_TH2_Human1.94894740
38* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87127005
39GATA3_27048872_Chip-Seq_THYMUS_Human1.85941288
40LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.85644146
41KDM2B_26808549_Chip-Seq_DND41_Human1.84843937
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80430628
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.78328823
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.77788252
45GATA1_19941827_ChIP-Seq_MEL_Mouse1.75519939
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75369698
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74095782
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.69647171
49VDR_24787735_ChIP-Seq_THP-1_Human1.60104695
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59412064
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58390130
52GATA1_19941826_ChIP-Seq_K562_Human1.57964531
53SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52586837
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.52053051
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50626002
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49254552
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.48487706
58GATA1_22025678_ChIP-Seq_K562_Human1.47276366
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.43536443
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43160967
61GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.40906669
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40109581
63CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38073118
64GATA3_26560356_Chip-Seq_TH2_Human1.37307905
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33037789
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.32880345
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.30681994
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.30670239
69PU_27001747_Chip-Seq_BMDM_Mouse1.28589321
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28045295
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27059636
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26550963
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22936043
74SMAD_19615063_ChIP-ChIP_OVARY_Human1.22418304
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19556892
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18388888
77GATA2_19941826_ChIP-Seq_K562_Human1.18352740
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17789285
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15513422
80RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14153191
81PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12589880
82PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12342087
83VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11092285
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10733043
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09278493
86BCL6_27268052_Chip-Seq_Bcells_Human1.08986852
87* LXR_22292898_ChIP-Seq_THP-1_Human1.08506222
88NCOR1_26117541_ChIP-Seq_K562_Human1.08009129
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07718768
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06507084
91RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05717204
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03428846
93BCOR_27268052_Chip-Seq_Bcells_Human1.01874176
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.97269909
95CIITA_25753668_ChIP-Seq_RAJI_Human0.97236914
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.91866074
97SPI1_20517297_ChIP-Seq_HL60_Human0.91208067
98* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89198889
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88928739
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84331984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.37253854
2MP0003436_decreased_susceptibility_to4.09704743
3MP0001835_abnormal_antigen_presentation3.87202570
4MP0003303_peritoneal_inflammation3.42951541
5MP0005671_abnormal_response_to3.14752191
6MP0003763_abnormal_thymus_physiology3.05371712
7MP0001800_abnormal_humoral_immune3.04482512
8MP0002419_abnormal_innate_immunity3.02213708
9MP0005464_abnormal_platelet_physiology2.94635847
10MP0005025_abnormal_response_to2.84756325
11MP0005000_abnormal_immune_tolerance2.84099748
12MP0005387_immune_system_phenotype2.70152322
13MP0001790_abnormal_immune_system2.70152322
14MP0002420_abnormal_adaptive_immunity2.66514717
15MP0002723_abnormal_immune_serum2.64841746
16MP0001819_abnormal_immune_cell2.63369681
17MP0000685_abnormal_immune_system2.59406007
18MP0002452_abnormal_antigen_presenting2.55440290
19MP0006082_CNS_inflammation2.52465724
20MP0009785_altered_susceptibility_to2.45653880
21MP0002396_abnormal_hematopoietic_system2.42208137
22MP0002398_abnormal_bone_marrow2.30178215
23MP0003300_gastrointestinal_ulcer2.26864636
24MP0002405_respiratory_system_inflammati2.15728567
25MP0000716_abnormal_immune_system2.08590294
26MP0000465_gastrointestinal_hemorrhage2.07349380
27MP0002148_abnormal_hypersensitivity_rea2.07234300
28MP0009333_abnormal_splenocyte_physiolog1.96185788
29MP0003172_abnormal_lysosome_physiology1.94528497
30MP0009278_abnormal_bone_marrow1.94210622
31MP0001533_abnormal_skeleton_physiology1.92920915
32MP0002132_abnormal_respiratory_system1.91818007
33MP0000689_abnormal_spleen_morphology1.91069872
34MP0002722_abnormal_immune_system1.88255114
35MP0010155_abnormal_intestine_physiology1.83191961
36MP0003828_pulmonary_edema1.82646755
37MP0000703_abnormal_thymus_morphology1.79999026
38MP0003191_abnormal_cellular_cholesterol1.79775093
39MP0005397_hematopoietic_system_phenotyp1.74283762
40MP0001545_abnormal_hematopoietic_system1.74283762
41MP0002429_abnormal_blood_cell1.71773032
42MP0008260_abnormal_autophagy1.71628850
43MP0003866_abnormal_defecation1.67744651
44MP0001845_abnormal_inflammatory_respons1.67089350
45MP0004947_skin_inflammation1.63351790
46MP0001851_eye_inflammation1.59281913
47MP0008469_abnormal_protein_level1.37415922
48MP0004808_abnormal_hematopoietic_stem1.36659187
49MP0004381_abnormal_hair_follicle1.29295882
50MP0002166_altered_tumor_susceptibility1.26737826
51MP0002009_preneoplasia1.26396012
52MP0003183_abnormal_peptide_metabolism1.22724339
53MP0001873_stomach_inflammation1.22582888
54MP0009764_decreased_sensitivity_to1.22552171
55MP0000858_altered_metastatic_potential1.22058168
56MP0001986_abnormal_taste_sensitivity1.20487763
57MP0003656_abnormal_erythrocyte_physiolo1.20008181
58MP0004883_abnormal_blood_vessel1.14707318
59MP0008004_abnormal_stomach_pH1.14075208
60MP0002998_abnormal_bone_remodeling1.13887659
61MP0005310_abnormal_salivary_gland1.10994818
62MP0005058_abnormal_lysosome_morphology1.08834040
63MP0005451_abnormal_body_composition1.07469799
64MP0005075_abnormal_melanosome_morpholog1.03399997
65MP0003690_abnormal_glial_cell0.94116585
66MP0004510_myositis0.91107789
67MP0001663_abnormal_digestive_system0.91100902
68MP0003075_altered_response_to0.89305496
69MP0000490_abnormal_crypts_of0.88186800
70MP0005166_decreased_susceptibility_to0.87699357
71MP0001853_heart_inflammation0.86559544
72MP0002933_joint_inflammation0.84920711
73MP0009763_increased_sensitivity_to0.84903470
74MP0000015_abnormal_ear_pigmentation0.81839993
75MP0005164_abnormal_response_to0.81543325
76MP0002277_abnormal_respiratory_mucosa0.81081597
77MP0005390_skeleton_phenotype0.79096048
78MP0004130_abnormal_muscle_cell0.78602234
79MP0002006_tumorigenesis0.70877112
80MP0003448_altered_tumor_morphology0.70629710
81MP0009765_abnormal_xenobiotic_induced0.70566906
82MP0005083_abnormal_biliary_tract0.69192944
83MP0002019_abnormal_tumor_incidence0.68111224
84MP0000249_abnormal_blood_vessel0.67323555
85MP0000343_altered_response_to0.67166222
86MP0003795_abnormal_bone_structure0.64246053
87MP0000604_amyloidosis0.59307067
88MP0003045_fibrosis0.57851788
89MP0003806_abnormal_nucleotide_metabolis0.57713967
90MP0008874_decreased_physiological_sensi0.56107361
91MP0002138_abnormal_hepatobiliary_system0.53826444
92MP0002928_abnormal_bile_duct0.52238782
93MP0004484_altered_response_of0.49912458
94MP0005319_abnormal_enzyme/_coenzyme0.47596844
95MP0002693_abnormal_pancreas_physiology0.47501218
96MP0005381_digestive/alimentary_phenotyp0.46842356
97MP0005535_abnormal_body_temperature0.46279426
98MP0008873_increased_physiological_sensi0.44346404
99MP0005084_abnormal_gallbladder_morpholo0.44292549
100MP0008961_abnormal_basal_metabolism0.44230898

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.38380265
2Recurrent abscess formation (HP:0002722)5.65934031
3Recurrent bacterial skin infections (HP:0005406)5.57450028
4Myositis (HP:0100614)5.34241224
5Abnormality of macrophages (HP:0004311)5.01273076
6Prolonged bleeding time (HP:0003010)4.89729925
7Elevated erythrocyte sedimentation rate (HP:0003565)4.75877960
8Stomatitis (HP:0010280)4.61728309
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.48053728
10Orchitis (HP:0100796)4.43214515
11Recurrent fungal infections (HP:0002841)4.39298683
12Recurrent gram-negative bacterial infections (HP:0005420)4.29902975
13Retrobulbar optic neuritis (HP:0100654)4.25806043
14Optic neuritis (HP:0100653)4.25806043
15Obstructive lung disease (HP:0006536)4.12778854
16Chronic obstructive pulmonary disease (HP:0006510)4.12778854
17Meningitis (HP:0001287)4.04008423
18Gastrointestinal infarctions (HP:0005244)4.03122499
19Panhypogammaglobulinemia (HP:0003139)3.99816498
20Spontaneous hematomas (HP:0007420)3.90137154
21Encephalitis (HP:0002383)3.87867118
22Recurrent skin infections (HP:0001581)3.87272310
23Chronic mucocutaneous candidiasis (HP:0002728)3.82423718
24Recurrent cutaneous fungal infections (HP:0011370)3.82423718
25Mediastinal lymphadenopathy (HP:0100721)3.71958653
26Epistaxis (HP:0000421)3.70947292
27Increased IgE level (HP:0003212)3.49972219
28Pustule (HP:0200039)3.49192630
29Hypochromic microcytic anemia (HP:0004840)3.47943443
30T lymphocytopenia (HP:0005403)3.45379496
31Gingival bleeding (HP:0000225)3.44920758
32Recurrent viral infections (HP:0004429)3.33237308
33Vasculitis (HP:0002633)3.32735279
34Petechiae (HP:0000967)3.31878054
35Chest pain (HP:0100749)3.29598651
36Abnormality of T cell number (HP:0011839)3.29442868
37Inflammation of the large intestine (HP:0002037)3.24495754
38Gastrointestinal inflammation (HP:0004386)3.18272157
39Urticaria (HP:0001025)3.16676310
40Hypochromic anemia (HP:0001931)3.13217252
41Gingivitis (HP:0000230)3.11606574
42Keratoconjunctivitis sicca (HP:0001097)3.11514641
43Cellulitis (HP:0100658)3.07898250
44Abnormality of T cells (HP:0002843)3.05126646
45Leukocytosis (HP:0001974)3.03126615
46Granulocytopenia (HP:0001913)2.98056409
47Agammaglobulinemia (HP:0004432)2.93769156
48Keratoconjunctivitis (HP:0001096)2.87302592
49Abnormal platelet volume (HP:0011876)2.84440094
50Purpura (HP:0000979)2.75362182
51Pulmonary infiltrates (HP:0002113)2.73435488
52Arterial thrombosis (HP:0004420)2.71394302
53Colitis (HP:0002583)2.70925186
54Hemoptysis (HP:0002105)2.70327348
55Episodic fever (HP:0001954)2.70318335
56Abnormality of T cell physiology (HP:0011840)2.62352157
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.60851286
58Increased IgM level (HP:0003496)2.59431667
59Pulmonary embolism (HP:0002204)2.58336405
60Microcytic anemia (HP:0001935)2.58251746
61Anorexia (HP:0002039)2.47690813
62Osteomyelitis (HP:0002754)2.44902892
63Autoimmune hemolytic anemia (HP:0001890)2.35888191
64Papilledema (HP:0001085)2.34282451
65Lymphopenia (HP:0001888)2.33872710
66Eosinophilia (HP:0001880)2.33531850
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30644026
68Viral hepatitis (HP:0006562)2.29855002
69Hypergammaglobulinemia (HP:0010702)2.26121345
70Sepsis (HP:0100806)2.23540043
71Menorrhagia (HP:0000132)2.20321482
72Amyloidosis (HP:0011034)2.20231293
73Abnormality of cells of the lymphoid lineage (HP:0012140)2.18552971
74Abnormality of iron homeostasis (HP:0011031)2.17088730
75Peritonitis (HP:0002586)2.15556632
76Papilloma (HP:0012740)2.14776674
77Verrucae (HP:0200043)2.14776674
78Increased serum ferritin (HP:0003281)2.13391211
79IgM deficiency (HP:0002850)2.12972447
80Thrombocytosis (HP:0001894)2.11900232
81Chronic otitis media (HP:0000389)2.09622650
82Skin ulcer (HP:0200042)2.06715577
83Acute hepatic failure (HP:0006554)2.05918566
84Increased mean platelet volume (HP:0011877)2.04855894
85Hepatosplenomegaly (HP:0001433)2.02738668
86Abnormality of the pleura (HP:0002103)2.02307984
87Slow saccadic eye movements (HP:0000514)2.02288158
88Joint swelling (HP:0001386)2.02274791
89Vertigo (HP:0002321)2.00682523
90Abnormality of eosinophils (HP:0001879)1.99886575
91Autoimmune thrombocytopenia (HP:0001973)1.99626672
92Gangrene (HP:0100758)1.96286308
93Severe combined immunodeficiency (HP:0004430)1.96241043
94Abnormal platelet function (HP:0011869)1.94512375
95Impaired platelet aggregation (HP:0003540)1.94512375
96Glomerulopathy (HP:0100820)1.93626424
97Abnormality of the fingertips (HP:0001211)1.93584986
98Polycythemia (HP:0001901)1.91227406
99Amaurosis fugax (HP:0100576)1.89471600
100Increased cerebral lipofuscin (HP:0011813)1.89356679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.60164345
2MAP4K14.21038918
3PRPF4B2.98352133
4FES2.97518052
5BLK2.97374383
6MAP2K32.82840252
7TYK22.55340849
8GRK62.47985386
9TNK22.44776661
10ZAP702.39975969
11IRAK42.36354937
12CSK2.33045116
13BTK2.24385206
14TXK2.22266256
15ERN12.02675184
16SYK2.01630104
17JAK31.91775212
18HCK1.81354082
19MAP3K131.76788093
20TAOK31.72858125
21TEC1.68692465
22KIT1.60269571
23IKBKE1.56244099
24ITK1.54900703
25MAP3K141.53660179
26MAP3K31.52581907
27CSF1R1.50582900
28TAOK11.47665675
29LYN1.45333195
30TBK11.44473054
31FGR1.40454416
32EPHB11.39129005
33LCK1.36761352
34JAK11.35131344
35SIK31.35095440
36MAP3K111.33750414
37JAK21.25085354
38MARK31.21232557
39MAP3K11.08702100
40TESK21.00246881
41MARK20.97747857
42IKBKB0.95063347
43BMPR20.93660580
44YES10.92668187
45TRIB30.92460177
46SIK20.90532190
47STK100.89931188
48PDK10.89375790
49CDK190.86712240
50MAP3K70.86263365
51MAPK120.86242616
52PRKD20.81452053
53KSR20.81250337
54MAPK70.78639026
55PRKCQ0.78212619
56TAOK20.76447104
57HIPK20.75979708
58MATK0.74621996
59PTK60.69168272
60IRAK10.67502805
61PDPK10.66709892
62FYN0.65321445
63PTK2B0.64240238
64MAP3K60.64024808
65PIK3CG0.63666573
66PIM10.63624122
67LRRK20.62317322
68FGFR30.61474366
69IRAK20.61114253
70CDC42BPA0.59369055
71SMG10.58967327
72CDK40.56564597
73MAP3K100.54496687
74NLK0.54099117
75RPS6KL10.53613080
76RPS6KC10.53613080
77DYRK1B0.53547652
78CDK60.49110576
79STK110.49003261
80TGFBR20.48374557
81CAMKK10.46502698
82SGK30.45264030
83RPS6KA60.45140620
84MAP3K50.44626755
85RET0.43484445
86CAMKK20.40677364
87BMX0.40374546
88SIK10.35940755
89TTN0.35675077
90PASK0.33883300
91STK380.33702667
92MAP2K20.31845951
93MAPKAPK20.31192727
94SGK20.30573033
95CDK120.29651853
96MAP2K40.28655757
97RAF10.27851132
98PRKCH0.27637276
99MAP3K20.27330048
100PRKD10.26662472

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.85923527
2Osteoclast differentiation_Homo sapiens_hsa043802.71912462
3Primary immunodeficiency_Homo sapiens_hsa053402.67121805
4Graft-versus-host disease_Homo sapiens_hsa053322.62765487
5Allograft rejection_Homo sapiens_hsa053302.52758050
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.44168826
7B cell receptor signaling pathway_Homo sapiens_hsa046622.40726711
8Staphylococcus aureus infection_Homo sapiens_hsa051502.39122460
9Autoimmune thyroid disease_Homo sapiens_hsa053202.36241146
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.98525631
11Hematopoietic cell lineage_Homo sapiens_hsa046401.94861762
12T cell receptor signaling pathway_Homo sapiens_hsa046601.92995465
13Tuberculosis_Homo sapiens_hsa051521.91365262
14Acute myeloid leukemia_Homo sapiens_hsa052211.89545043
15Type I diabetes mellitus_Homo sapiens_hsa049401.86033749
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84334639
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.80055967
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.78831548
19Antigen processing and presentation_Homo sapiens_hsa046121.78569776
20Platelet activation_Homo sapiens_hsa046111.73955638
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.73009221
22Malaria_Homo sapiens_hsa051441.72410092
23Measles_Homo sapiens_hsa051621.72271565
24Chemokine signaling pathway_Homo sapiens_hsa040621.64286104
25Viral myocarditis_Homo sapiens_hsa054161.63775287
26Asthma_Homo sapiens_hsa053101.55599282
27Other glycan degradation_Homo sapiens_hsa005111.52050765
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.52018854
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.48405672
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44573113
31Herpes simplex infection_Homo sapiens_hsa051681.42559122
32Toxoplasmosis_Homo sapiens_hsa051451.42306697
33Influenza A_Homo sapiens_hsa051641.39191192
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.35791496
35Non-small cell lung cancer_Homo sapiens_hsa052231.33147335
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24455757
37Legionellosis_Homo sapiens_hsa051341.23227715
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.23079051
39African trypanosomiasis_Homo sapiens_hsa051431.17143633
40Hepatitis B_Homo sapiens_hsa051611.12340554
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11919757
42Phagosome_Homo sapiens_hsa041451.08579294
43Chronic myeloid leukemia_Homo sapiens_hsa052201.07023760
44Pancreatic cancer_Homo sapiens_hsa052121.06746315
45TNF signaling pathway_Homo sapiens_hsa046681.06472275
46VEGF signaling pathway_Homo sapiens_hsa043700.93374011
47Shigellosis_Homo sapiens_hsa051310.90887174
48Hepatitis C_Homo sapiens_hsa051600.88272141
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87736532
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87411480
51Rheumatoid arthritis_Homo sapiens_hsa053230.86426984
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84885158
53Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83784480
54Apoptosis_Homo sapiens_hsa042100.83661601
55Pertussis_Homo sapiens_hsa051330.82435515
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.79828815
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79749643
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.78771461
59Renal cell carcinoma_Homo sapiens_hsa052110.78670770
60Choline metabolism in cancer_Homo sapiens_hsa052310.77292204
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75630289
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73875422
63Endocytosis_Homo sapiens_hsa041440.71921665
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70798381
65Epstein-Barr virus infection_Homo sapiens_hsa051690.70017720
66Prolactin signaling pathway_Homo sapiens_hsa049170.69549856
67Salmonella infection_Homo sapiens_hsa051320.69062744
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67579633
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67278270
70Inositol phosphate metabolism_Homo sapiens_hsa005620.66582170
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66559928
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.66204721
73HTLV-I infection_Homo sapiens_hsa051660.65322656
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65253607
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.65228598
76Viral carcinogenesis_Homo sapiens_hsa052030.65016357
77Notch signaling pathway_Homo sapiens_hsa043300.64654387
78FoxO signaling pathway_Homo sapiens_hsa040680.63831017
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61068109
80Colorectal cancer_Homo sapiens_hsa052100.60867646
81GnRH signaling pathway_Homo sapiens_hsa049120.60732862
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.60255485
83Endometrial cancer_Homo sapiens_hsa052130.59614221
84Regulation of autophagy_Homo sapiens_hsa041400.59489943
85mTOR signaling pathway_Homo sapiens_hsa041500.59395846
86Lysosome_Homo sapiens_hsa041420.58262377
87Dorso-ventral axis formation_Homo sapiens_hsa043200.57160002
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.51554765
89MAPK signaling pathway_Homo sapiens_hsa040100.50291769
90Amoebiasis_Homo sapiens_hsa051460.49571081
91Insulin resistance_Homo sapiens_hsa049310.49458080
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48737285
93Rap1 signaling pathway_Homo sapiens_hsa040150.42218752
94HIF-1 signaling pathway_Homo sapiens_hsa040660.41114946
95Long-term potentiation_Homo sapiens_hsa047200.40677665
96Type II diabetes mellitus_Homo sapiens_hsa049300.36167339
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35333229
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34529807
99Ras signaling pathway_Homo sapiens_hsa040140.34318461
100ErbB signaling pathway_Homo sapiens_hsa040120.33824219

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »