ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	COPI coating of Golgi vesicle (GO:0048205)	6.16423681
2	Golgi transport vesicle coating (GO:0048200)	6.16423681
3	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	5.04065792
4	protein retention in ER lumen (GO:0006621)	5.01871782
5	proline biosynthetic process (GO:0006561)	4.52502397
6	skin morphogenesis (GO:0043589)	4.42579532
7	protein maturation by protein folding (GO:0022417)	4.19047499
8	basement membrane organization (GO:0071711)	3.98232571
9	adhesion of symbiont to host (GO:0044406)	3.96015031
10	virion attachment to host cell (GO:0019062)	3.92200215
11	adhesion of symbiont to host cell (GO:0044650)	3.92200215
12	GDP-mannose metabolic process (GO:0019673)	3.89068389
13	peptidyl-glutamic acid carboxylation (GO:0017187)	3.75512568
14	protein carboxylation (GO:0018214)	3.75512568
15	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	3.74612456
16	regulation of plasminogen activation (GO:0010755)	3.70883158
17	proline metabolic process (GO:0006560)	3.70423733
18	type B pancreatic cell proliferation (GO:0044342)	3.56274170
19	hemidesmosome assembly (GO:0031581)	3.53552660
20	COPII vesicle coating (GO:0048208)	3.51141401
21	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.50869563
22	nucleotide-sugar biosynthetic process (GO:0009226)	3.49278830
23	very-low-density lipoprotein particle assembly (GO:0034379)	3.48620645
24	cell adhesion mediated by integrin (GO:0033627)	3.46741229
25	endodermal cell differentiation (GO:0035987)	3.41729099
26	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	3.34884795
27	protein heterotrimerization (GO:0070208)	3.32973411
28	pinocytosis (GO:0006907)	3.28101322
29	regulation of extracellular matrix disassembly (GO:0010715)	3.26400076
30	actin filament depolymerization (GO:0030042)	3.23965759
31	collagen fibril organization (GO:0030199)	3.22315162
32	NADH metabolic process (GO:0006734)	3.13704389
33	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.13517922
34	peptidyl-proline hydroxylation (GO:0019511)	3.11658988
35	4-hydroxyproline metabolic process (GO:0019471)	3.10926042
36	plasma lipoprotein particle assembly (GO:0034377)	3.09660216
37	negative regulation of fibrinolysis (GO:0051918)	3.08277439
38	regulation of early endosome to late endosome transport (GO:2000641)	3.06977926
39	protein-lipid complex assembly (GO:0065005)	3.06558533
40	extracellular fibril organization (GO:0043206)	3.04245224
41	protein localization to endosome (GO:0036010)	3.04085840
42	barbed-end actin filament capping (GO:0051016)	3.03761676
43	activation of signaling protein activity involved in unfolded protein response (GO:0006987)	3.03461606
44	cell-substrate junction assembly (GO:0007044)	3.01007652
45	hyaluronan catabolic process (GO:0030214)	2.98463229
46	glutamine family amino acid biosynthetic process (GO:0009084)	2.95706332
47	urea cycle (GO:0000050)	2.93600823
48	regulation of metalloenzyme activity (GO:0048552)	2.92460492
49	positive regulation of nuclease activity (GO:0032075)	2.92355105
50	UV protection (GO:0009650)	2.90651340
51	regulation of cholesterol esterification (GO:0010872)	2.88629549
52	fibril organization (GO:0097435)	2.86572732
53	vesicle coating (GO:0006901)	2.85833024
54	endoplasmic reticulum unfolded protein response (GO:0030968)	2.81587400
55	urea metabolic process (GO:0019627)	2.79649896
56	protein hydroxylation (GO:0018126)	2.79476970
57	chondrocyte proliferation (GO:0035988)	2.78707649
58	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	2.78197658
59	positive regulation of extracellular matrix organization (GO:1903055)	2.77572321
60	desmosome organization (GO:0002934)	2.76791835
61	fibrinolysis (GO:0042730)	2.66311747
62	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.65870583
63	regulation of fibrinolysis (GO:0051917)	2.65311448
64	endothelial cell morphogenesis (GO:0001886)	2.63906006
65	stress fiber assembly (GO:0043149)	2.63741810
66	angiotensin maturation (GO:0002003)	2.63514600
67	cellular response to unfolded protein (GO:0034620)	2.61805934
68	regulation of cholesterol homeostasis (GO:2000188)	2.60377225
69	nitrogen cycle metabolic process (GO:0071941)	2.57617324
70	mitotic nuclear envelope reassembly (GO:0007084)	2.56455828
71	nuclear envelope reassembly (GO:0031468)	2.56455828
72	cellular copper ion homeostasis (GO:0006878)	2.55644492
73	glycosphingolipid catabolic process (GO:0046479)	2.54849884
74	ER-nucleus signaling pathway (GO:0006984)	2.54641690
75	regulation of nuclease activity (GO:0032069)	2.54418595
76	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.53779934
77	apoptotic cell clearance (GO:0043277)	2.53564495
78	intestinal absorption (GO:0050892)	2.52868986
79	epithelial cell-cell adhesion (GO:0090136)	2.52609505
80	nucleobase-containing small molecule interconversion (GO:0015949)	2.52129738
81	multicellular organismal macromolecule metabolic process (GO:0044259)	2.49228691
82	positive regulation of pseudopodium assembly (GO:0031274)	2.48842395
83	negative regulation of smooth muscle cell migration (GO:0014912)	2.48070224
84	nucleoside diphosphate biosynthetic process (GO:0009133)	2.46895201
85	collagen metabolic process (GO:0032963)	2.46875459
86	cell-substrate adherens junction assembly (GO:0007045)	2.46137892
87	focal adhesion assembly (GO:0048041)	2.46137892
88	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.44773139
89	cellular response to topologically incorrect protein (GO:0035967)	2.43546885
90	glucose 6-phosphate metabolic process (GO:0051156)	2.41421013
91	extracellular matrix disassembly (GO:0022617)	2.40359822
92	adherens junction assembly (GO:0034333)	2.39579051
93	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.39288815
94	multicellular organismal metabolic process (GO:0044236)	2.37802468
95	protein N-linked glycosylation via asparagine (GO:0018279)	2.37668397
96	positive regulation of osteoblast proliferation (GO:0033690)	2.37275728
97	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.37103562
98	L-phenylalanine metabolic process (GO:0006558)	2.37103562
99	glycolipid catabolic process (GO:0019377)	2.34846162
100	peptidyl-asparagine modification (GO:0018196)	2.34096738

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.57790938
2	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.43393018
3	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.96949912
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.95604863
5	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.87092720
6	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.71446147
7	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.65853184
8	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.54529780
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.50258239
10	ELK3_25401928_ChIP-Seq_HUVEC_Human	2.37541270
11	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.27662346
12	LXR_22292898_ChIP-Seq_THP-1_Human	2.16999036
13	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.12436985
14	CLOCK_20551151_ChIP-Seq_293T_Human	2.01005409
15	RACK7_27058665_Chip-Seq_MCF-7_Human	1.93676806
16	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.89941787
17	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.85676701
18	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.84206592
19	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.81507744
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.80955745
21	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.78799761
22	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.78455810
23	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.77202841
24	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.74871416
25	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.72321262
26	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.70052395
27	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.67292491
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.65167417
29	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.63772292
30	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.61353082
31	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.59123288
32	ATF3_27146783_Chip-Seq_COLON_Human	1.58074756
33	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.57580635
34	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.55729687
35	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.50469462
36	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.48856974
37	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.48253792
38	E2F7_22180533_ChIP-Seq_HELA_Human	1.45637520
39	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.44677340
40	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.43069820
41	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.42905009
42	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.41262706
43	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.40648819
44	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.40647278
45	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.40360219
46	VDR_21846776_ChIP-Seq_THP-1_Human	1.39966118
47	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.39049465
48	AR_21909140_ChIP-Seq_LNCAP_Human	1.38532286
49	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.36218581
50	P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.35848526
51	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.35429161
52	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.35323264
53	TP53_22127205_ChIP-Seq_IMR90_Human	1.33316505
54	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.30453940
55	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.30316133
56	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.29890566
57	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.27693003
58	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.27673709
59	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.27033644
60	MYC_22102868_ChIP-Seq_BL_Human	1.25181355
61	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.24830054
62	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.24074648
63	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.22132806
64	* UBF1/2_26484160_Chip-Seq_HMECs_Human	1.21782216
65	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.19638908
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.19565394
67	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.18311209
68	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.18097684
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.16958705
70	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.14778487
71	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.12644017
72	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.11211842
73	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.10472770
74	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.09833444
75	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.09471367
76	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.08191424
77	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.08191424
78	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.05760190
79	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.05546962
80	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.04782437
81	* GABP_19822575_ChIP-Seq_HepG2_Human	1.03893399
82	TFEB_21752829_ChIP-Seq_HELA_Human	1.03412961
83	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.02755640
84	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.01673033
85	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.01506657
86	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.00728979
87	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.00397120
88	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.98009035
89	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.97380126
90	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.97320545
91	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.97310594
92	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.96921720
93	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.96306301
94	P68_20966046_ChIP-Seq_HELA_Human	0.96196060
95	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.95299584
96	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.95271553
97	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.95078580
98	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.95073989
99	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.94956616
100	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.94178296

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	6.53217733
2	MP0003705_abnormal_hypodermis_morpholog	4.01308771
3	MP0005360_urolithiasis	3.74631346
4	MP0005257_abnormal_intraocular_pressure	3.57094533
5	MP0004272_abnormal_basement_membrane	3.45663455
6	MP0009840_abnormal_foam_cell	3.01543935
7	MP0003566_abnormal_cell_adhesion	2.78006840
8	MP0005275_abnormal_skin_tensile	2.68025957
9	MP0005058_abnormal_lysosome_morphology	2.60562402
10	MP0003279_aneurysm	2.39337447
11	MP0005503_abnormal_tendon_morphology	2.34961085
12	MP0005451_abnormal_body_composition	2.23183665
13	MP0002877_abnormal_melanocyte_morpholog	2.15643911
14	MP0005623_abnormal_meninges_morphology	2.15588604
15	MP0009384_cardiac_valve_regurgitation	2.07029626
16	MP0001958_emphysema	2.06208588
17	MP0004858_abnormal_nervous_system	1.99356780
18	MP0005023_abnormal_wound_healing	1.97528879
19	MP0002060_abnormal_skin_morphology	1.88109528
20	MP0002139_abnormal_hepatobiliary_system	1.87326712
21	MP0008260_abnormal_autophagy	1.74179293
22	MP0010030_abnormal_orbit_morphology	1.70468292
23	MP0003950_abnormal_plasma_membrane	1.65534152
24	MP0001542_abnormal_bone_strength	1.64109744
25	MP0005408_hypopigmentation	1.60496823
26	MP0006054_spinal_hemorrhage	1.58407729
27	MP0003191_abnormal_cellular_cholesterol	1.56339333
28	MP0000013_abnormal_adipose_tissue	1.51046623
29	MP0001849_ear_inflammation	1.49803974
30	MP0001666_abnormal_nutrient_absorption	1.49549707
31	MP0010368_abnormal_lymphatic_system	1.42744209
32	MP0000003_abnormal_adipose_tissue	1.40272667
33	MP0010352_gastrointestinal_tract_polyps	1.39454700
34	MP0003091_abnormal_cell_migration	1.34447178
35	MP0005365_abnormal_bile_salt	1.31901303
36	MP0000858_altered_metastatic_potential	1.30489229
37	MP0003941_abnormal_skin_development	1.28442047
38	MP0000751_myopathy	1.27777725
39	MP0001243_abnormal_dermal_layer	1.24213757
40	MP0005508_abnormal_skeleton_morphology	1.20428374
41	MP0002089_abnormal_postnatal_growth/wei	1.20285883
42	MP0005085_abnormal_gallbladder_physiolo	1.19082722
43	MP0000767_abnormal_smooth_muscle	1.18142576
44	MP0005171_absent_coat_pigmentation	1.15127431
45	MP0000678_abnormal_parathyroid_gland	1.14955083
46	MP0005501_abnormal_skin_physiology	1.13815245
47	MP0005409_darkened_coat_color	1.10936204
48	MP0002896_abnormal_bone_mineralization	1.09994230
49	MP0004233_abnormal_muscle_weight	1.08859181
50	MP0003453_abnormal_keratinocyte_physiol	1.07515938
51	MP0010234_abnormal_vibrissa_follicle	1.04864348
52	MP0000762_abnormal_tongue_morphology	1.01978562
53	MP0009053_abnormal_anal_canal	0.95741966
54	MP0005197_abnormal_uvea_morphology	0.93038312
55	MP0003806_abnormal_nucleotide_metabolis	0.92401203
56	MP0008932_abnormal_embryonic_tissue	0.92288323
57	MP0002295_abnormal_pulmonary_circulatio	0.91089336
58	MP0005165_increased_susceptibility_to	0.90702062
59	MP0001915_intracranial_hemorrhage	0.88157123
60	MP0002796_impaired_skin_barrier	0.86993036
61	MP0003186_abnormal_redox_activity	0.86729643
62	MP0003172_abnormal_lysosome_physiology	0.82827111
63	MP0001216_abnormal_epidermal_layer	0.80816481
64	MP0004019_abnormal_vitamin_homeostasis	0.80586394
65	MP0010329_abnormal_lipoprotein_level	0.80306390
66	MP0005332_abnormal_amino_acid	0.77645446
67	MP0000467_abnormal_esophagus_morphology	0.77210912
68	MP0003868_abnormal_feces_composition	0.75795053
69	MP0000534_abnormal_ureter_morphology	0.74879809
70	MP0005621_abnormal_cell_physiology	0.73616338
71	MP0000490_abnormal_crypts_of	0.73180951
72	MP0001730_embryonic_growth_arrest	0.71861898
73	MP0005076_abnormal_cell_differentiation	0.70923294
74	MP0002254_reproductive_system_inflammat	0.69855833
75	MP0005390_skeleton_phenotype	0.69509982
76	MP0001661_extended_life_span	0.69342945
77	MP0004957_abnormal_blastocyst_morpholog	0.68707374
78	MP0003448_altered_tumor_morphology	0.68269878
79	MP0005164_abnormal_response_to	0.67082448
80	MP0000462_abnormal_digestive_system	0.66991042
81	MP0003111_abnormal_nucleus_morphology	0.66505550
82	MP0005375_adipose_tissue_phenotype	0.66119126
83	MP0009780_abnormal_chondrocyte_physiolo	0.65758677
84	MP0005193_abnormal_anterior_eye	0.65566003
85	MP0000538_abnormal_urinary_bladder	0.65170225
86	MP0001299_abnormal_eye_distance/	0.64596229
87	MP0003385_abnormal_body_wall	0.64586659
88	MP0000343_altered_response_to	0.64150433
89	MP0009250_abnormal_appendicular_skeleto	0.63881752
90	MP0004264_abnormal_extraembryonic_tissu	0.63812403
91	MP0005330_cardiomyopathy	0.63647353
92	MP0001881_abnormal_mammary_gland	0.62955107
93	MP0005670_abnormal_white_adipose	0.62572334
94	MP0010771_integument_phenotype	0.61983461
95	MP0000733_abnormal_muscle_development	0.61553748
96	MP0003693_abnormal_embryo_hatching	0.61497988
97	MP0000609_abnormal_liver_physiology	0.61293006
98	MP0000750_abnormal_muscle_regeneration	0.59901998
99	MP0003795_abnormal_bone_structure	0.59632438
100	MP0009333_abnormal_splenocyte_physiolog	0.58872042

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature rupture of membranes (HP:0001788)	7.00053439
2	Protrusio acetabuli (HP:0003179)	5.74587922
3	Vertebral compression fractures (HP:0002953)	3.86271750
4	Atrophic scars (HP:0001075)	3.62389618
5	Ankle contracture (HP:0006466)	3.49782158
6	Aortic dissection (HP:0002647)	3.26244865
7	Fragile skin (HP:0001030)	3.19069265
8	Bladder diverticulum (HP:0000015)	3.07752602
9	Follicular hyperkeratosis (HP:0007502)	3.02343052
10	Cervical subluxation (HP:0003308)	2.97024686
11	Deep venous thrombosis (HP:0002625)	2.96957408
12	Abnormality of dentin (HP:0010299)	2.92703398
13	Spinal rigidity (HP:0003306)	2.87980135
14	Upper limb amyotrophy (HP:0009129)	2.87978178
15	Distal upper limb amyotrophy (HP:0007149)	2.87978178
16	Wormian bones (HP:0002645)	2.87085496
17	Soft skin (HP:0000977)	2.86753255
18	Blue sclerae (HP:0000592)	2.82201083
19	Achilles tendon contracture (HP:0001771)	2.81512001
20	Abnormality of the Achilles tendon (HP:0005109)	2.75300723
21	Vascular tortuosity (HP:0004948)	2.74326051
22	Elbow flexion contracture (HP:0002987)	2.61579691
23	Aortic aneurysm (HP:0004942)	2.57416519
24	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.54474368
25	Shallow orbits (HP:0000586)	2.50806146
26	Abnormal delivery (HP:0001787)	2.49619831
27	Genu recurvatum (HP:0002816)	2.47361043
28	Abnormality of carpal bone ossification (HP:0006257)	2.45379124
29	Hand muscle atrophy (HP:0009130)	2.43740230
30	Biconcave vertebral bodies (HP:0004586)	2.43450047
31	Abnormality of the acetabulum (HP:0003170)	2.41712877
32	Arterial tortuosity (HP:0005116)	2.41203058
33	Cardiovascular calcification (HP:0011915)	2.38244502
34	Mildly elevated creatine phosphokinase (HP:0008180)	2.36461354
35	Ulnar bowing (HP:0003031)	2.33574621
36	Nonimmune hydrops fetalis (HP:0001790)	2.31572599
37	Increased connective tissue (HP:0009025)	2.30248358
38	Hypobetalipoproteinemia (HP:0003563)	2.27830952
39	Abnormal gallbladder physiology (HP:0012438)	2.26612344
40	Cholecystitis (HP:0001082)	2.26612344
41	Generalized amyotrophy (HP:0003700)	2.26065880
42	Neonatal short-limb short stature (HP:0008921)	2.25630051
43	Trismus (HP:0000211)	2.24418305
44	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.23218661
45	Osteolytic defects of the hand bones (HP:0009699)	2.23218661
46	Entropion (HP:0000621)	2.22646654
47	Xanthomatosis (HP:0000991)	2.21743667
48	Peritonitis (HP:0002586)	2.21610775
49	Cerebral aneurysm (HP:0004944)	2.19484854
50	Dilatation of the ascending aorta (HP:0005111)	2.18907453
51	Mitral stenosis (HP:0001718)	2.17755992
52	Systemic lupus erythematosus (HP:0002725)	2.15219231
53	Type 1 muscle fiber predominance (HP:0003803)	2.14697206
54	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.13854894
55	Abnormality of proline metabolism (HP:0010907)	2.11395289
56	Hydroxyprolinuria (HP:0003080)	2.11395289
57	Thin bony cortex (HP:0002753)	2.10657824
58	Short nail (HP:0001799)	2.09469326
59	Disproportionate tall stature (HP:0001519)	2.08174773
60	Slender build (HP:0001533)	2.07075149
61	Distal lower limb amyotrophy (HP:0008944)	2.06014759
62	Spondylolisthesis (HP:0003302)	2.05583175
63	Rough bone trabeculation (HP:0100670)	2.05392814
64	Abnormal ossification of hand bones (HP:0005921)	2.03815020
65	Natal tooth (HP:0000695)	2.03782186
66	Hyperextensible skin (HP:0000974)	2.02331455
67	Vascular calcification (HP:0004934)	2.01618565
68	Hypolipoproteinemia (HP:0010981)	1.98609094
69	Distal lower limb muscle weakness (HP:0009053)	1.97473206
70	Hemorrhage of the eye (HP:0011885)	1.94364213
71	Abnormality of the distal phalanges of the toes (HP:0010182)	1.94169467
72	Abnormality of complement system (HP:0005339)	1.93739627
73	Hyperacusis (HP:0010780)	1.93479892
74	Mitral regurgitation (HP:0001653)	1.93093245
75	Premature skin wrinkling (HP:0100678)	1.92405343
76	Joint stiffness (HP:0001387)	1.92140007
77	Reduced subcutaneous adipose tissue (HP:0003758)	1.89331867
78	Abnormality of the umbilical cord (HP:0010881)	1.88183851
79	Abnormality of glycolysis (HP:0004366)	1.86194889
80	Joint laxity (HP:0001388)	1.85860850
81	Increased variability in muscle fiber diameter (HP:0003557)	1.85656667
82	Coxa vara (HP:0002812)	1.84622419
83	Renal duplication (HP:0000075)	1.82920054
84	Increased serum pyruvate (HP:0003542)	1.81057093
85	Aneurysm (HP:0002617)	1.79192095
86	Myocardial infarction (HP:0001658)	1.78871876
87	Dysostosis multiplex (HP:0000943)	1.78551854
88	Bowel diverticulosis (HP:0005222)	1.77376473
89	Breech presentation (HP:0001623)	1.77250894
90	Mitral valve prolapse (HP:0001634)	1.75852012
91	Redundant skin (HP:0001582)	1.75411221
92	Ileus (HP:0002595)	1.74959098
93	Hypoalphalipoproteinemia (HP:0003233)	1.74609606
94	Broad metatarsal (HP:0001783)	1.73648861
95	Prolonged neonatal jaundice (HP:0006579)	1.71091903
96	Abnormality of skeletal muscle fiber size (HP:0012084)	1.71005017
97	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.70587737
98	Mucopolysacchariduria (HP:0008155)	1.70454805
99	Urinary glycosaminoglycan excretion (HP:0003541)	1.70454805
100	Back pain (HP:0003418)	1.69503621

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	3.87900639
2	NME2	3.29740100
3	TESK1	3.19458801
4	EPHA2	2.74628950
5	IRAK3	2.66482969
6	TRIB3	2.63161242
7	MST1R	2.53202796
8	SMG1	2.41209360
9	MYLK	2.37366528
10	TESK2	2.32440248
11	PAK4	2.29159251
12	PDGFRA	2.26352070
13	SIK1	2.24756253
14	ARAF	2.23944258
15	PIM2	2.18987808
16	LIMK1	2.16082978
17	RIPK1	2.09942591
18	PTK2	2.06409637
19	DDR2	1.83900001
20	FGFR4	1.79874022
21	ICK	1.78503366
22	TAOK2	1.72483983
23	MAP3K3	1.69476434
24	MET	1.57464363
25	LMTK2	1.52956818
26	BUB1	1.52852810
27	TTN	1.44046508
28	PRPF4B	1.42244632
29	EPHB2	1.38260891
30	PRKD2	1.28309673
31	ABL2	1.27911795
32	PAK2	1.23101242
33	VRK2	1.21759282
34	PDK2	1.16141810
35	SCYL2	1.13056929
36	ILK	1.10638377
37	LATS2	1.06742934
38	CDK12	1.05434663
39	PRKG2	1.05027378
40	NEK9	1.00255101
41	NEK1	0.98969149
42	CDC42BPA	0.98413027
43	MAP3K8	0.95364411
44	EEF2K	0.93197974
45	BRAF	0.92695470
46	PKN2	0.92388330
47	MAPKAPK3	0.92273063
48	NTRK1	0.91750553
49	EIF2AK1	0.91490262
50	ERBB4	0.90176298
51	TGFBR2	0.84841786
52	EPHB1	0.82242935
53	MAP3K11	0.80874934
54	CDK7	0.79722120
55	MAP3K10	0.79706501
56	MAPK11	0.77004450
57	MOS	0.76524806
58	PTK6	0.75152669
59	FLT3	0.74492816
60	MAP2K3	0.73244552
61	SIK3	0.70557702
62	CDK8	0.70191702
63	DAPK3	0.68979365
64	MTOR	0.68904896
65	CLK1	0.64312543
66	PAK1	0.62588749
67	KSR2	0.62207046
68	TBK1	0.61006032
69	MAP3K12	0.59552379
70	BRSK1	0.59432039
71	PDPK1	0.58678741
72	STK16	0.58424515
73	STK38	0.57997010
74	BMX	0.57188296
75	PBK	0.55025905
76	TYK2	0.54928657
77	BCKDK	0.50525242
78	MAP3K1	0.47271208
79	STK10	0.45793585
80	MAPKAPK2	0.45055293
81	TTK	0.44706663
82	AURKA	0.43903214
83	PRKCI	0.43675852
84	RPS6KA2	0.43075134
85	LRRK2	0.42833775
86	DMPK	0.41293354
87	GSK3A	0.40953271
88	PRKD3	0.38818443
89	TAOK1	0.37931576
90	AURKB	0.36230270
91	MAP3K13	0.35622398
92	CDK11A	0.35619442
93	AKT2	0.34634821
94	CDK15	0.34465378
95	ROCK2	0.33674331
96	CDK9	0.33530650
97	CAMK2G	0.32309743
98	DAPK1	0.32205767
99	CDK18	0.31672872
100	CDK4	0.29177341

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.04719368
2	Other glycan degradation_Homo sapiens_hsa00511	2.84740442
3	Sulfur relay system_Homo sapiens_hsa04122	2.77764717
4	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.75384152
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.52252687
6	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.48970983
7	Galactose metabolism_Homo sapiens_hsa00052	2.41361083
8	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.20709202
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.19557049
10	Biosynthesis of amino acids_Homo sapiens_hsa01230	2.16392483
11	Sulfur metabolism_Homo sapiens_hsa00920	2.10184424
12	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	2.04733332
13	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	2.02310474
14	ECM-receptor interaction_Homo sapiens_hsa04512	1.89523635
15	Arginine biosynthesis_Homo sapiens_hsa00220	1.88301318
16	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.87499424
17	Fat digestion and absorption_Homo sapiens_hsa04975	1.78874845
18	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.76978280
19	Complement and coagulation cascades_Homo sapiens_hsa04610	1.74530275
20	Pentose phosphate pathway_Homo sapiens_hsa00030	1.66563955
21	Renin-angiotensin system_Homo sapiens_hsa04614	1.60160400
22	Protein digestion and absorption_Homo sapiens_hsa04974	1.58244822
23	Proteasome_Homo sapiens_hsa03050	1.51909443
24	Carbon metabolism_Homo sapiens_hsa01200	1.47202723
25	Vibrio cholerae infection_Homo sapiens_hsa05110	1.44834575
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.44599928
27	Bladder cancer_Homo sapiens_hsa05219	1.42841076
28	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.40110686
29	Arginine and proline metabolism_Homo sapiens_hsa00330	1.34104941
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.31263595
31	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.28030928
32	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.27508070
33	Focal adhesion_Homo sapiens_hsa04510	1.27454378
34	Prion diseases_Homo sapiens_hsa05020	1.25738451
35	Glutathione metabolism_Homo sapiens_hsa00480	1.25667691
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.20144185
37	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.19658064
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.18231120
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.14335883
40	PPAR signaling pathway_Homo sapiens_hsa03320	1.09020410
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.07138817
42	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.04835841
43	Lysosome_Homo sapiens_hsa04142	1.04386066
44	Folate biosynthesis_Homo sapiens_hsa00790	1.04327704
45	Fatty acid elongation_Homo sapiens_hsa00062	1.02452788
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02265569
47	Sphingolipid metabolism_Homo sapiens_hsa00600	1.00730505
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.99595284
49	Small cell lung cancer_Homo sapiens_hsa05222	0.97711282
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.97389190
51	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95792274
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.91756873
53	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.89893355
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.88845154
55	Proteoglycans in cancer_Homo sapiens_hsa05205	0.85104598
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.84284926
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.84017377
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83661628
59	Amoebiasis_Homo sapiens_hsa05146	0.83281190
60	DNA replication_Homo sapiens_hsa03030	0.81302757
61	One carbon pool by folate_Homo sapiens_hsa00670	0.77937671
62	Mineral absorption_Homo sapiens_hsa04978	0.77656190
63	Base excision repair_Homo sapiens_hsa03410	0.75441607
64	Shigellosis_Homo sapiens_hsa05131	0.75343393
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69507415
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68677657
67	Fatty acid degradation_Homo sapiens_hsa00071	0.65458031
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63936672
69	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.63102499
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62618930
71	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.60283638
72	Bile secretion_Homo sapiens_hsa04976	0.59419103
73	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.55164181
74	Thyroid cancer_Homo sapiens_hsa05216	0.53802885
75	Fatty acid metabolism_Homo sapiens_hsa01212	0.49780874
76	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.45722961
77	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.45529152
78	Retinol metabolism_Homo sapiens_hsa00830	0.44776296
79	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.43662982
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.43562541
81	Adherens junction_Homo sapiens_hsa04520	0.43283109
82	Metabolic pathways_Homo sapiens_hsa01100	0.42971354
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42061511
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41202821
85	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.39935429
86	Pancreatic cancer_Homo sapiens_hsa05212	0.39881665
87	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.36397277
88	p53 signaling pathway_Homo sapiens_hsa04115	0.36267174
89	Salmonella infection_Homo sapiens_hsa05132	0.36237656
90	Pertussis_Homo sapiens_hsa05133	0.34932350
91	Apoptosis_Homo sapiens_hsa04210	0.34596375
92	Insulin resistance_Homo sapiens_hsa04931	0.33934276
93	AMPK signaling pathway_Homo sapiens_hsa04152	0.31488864
94	Prostate cancer_Homo sapiens_hsa05215	0.31392823
95	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.31225589
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.29977086
97	Endocytosis_Homo sapiens_hsa04144	0.29471319
98	Lysine degradation_Homo sapiens_hsa00310	0.25244586
99	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.25131006
100	Histidine metabolism_Homo sapiens_hsa00340	0.22671024

C11ORF24

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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