Rank | Gene Set | Z-score |
---|---|---|
1 | ribosomal small subunit assembly (GO:0000028) | 6.41033476 |
2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.10951860 |
3 | ribosomal small subunit biogenesis (GO:0042274) | 5.97773834 |
4 | chaperone-mediated protein transport (GO:0072321) | 5.86396436 |
5 | viral transcription (GO:0019083) | 5.85115113 |
6 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 5.65013341 |
7 | translational termination (GO:0006415) | 5.62214263 |
8 | ATP synthesis coupled proton transport (GO:0015986) | 5.58025182 |
9 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.58025182 |
10 | regulation of mitochondrial translation (GO:0070129) | 5.23378879 |
11 | maturation of SSU-rRNA (GO:0030490) | 5.23029622 |
12 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 5.13783754 |
13 | cotranslational protein targeting to membrane (GO:0006613) | 5.05151298 |
14 | protein targeting to ER (GO:0045047) | 5.03335553 |
15 | protein complex biogenesis (GO:0070271) | 5.02666085 |
16 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.95266624 |
17 | translational elongation (GO:0006414) | 4.93987787 |
18 | protein localization to endoplasmic reticulum (GO:0070972) | 4.80950739 |
19 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.80468542 |
20 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.78767117 |
21 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.74374035 |
22 | pyrimidine nucleotide catabolic process (GO:0006244) | 4.72325123 |
23 | respiratory electron transport chain (GO:0022904) | 4.72086866 |
24 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.67191751 |
25 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.67191751 |
26 | NADH dehydrogenase complex assembly (GO:0010257) | 4.67191751 |
27 | electron transport chain (GO:0022900) | 4.62177330 |
28 | viral life cycle (GO:0019058) | 4.48898416 |
29 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.45515703 |
30 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 4.31670051 |
31 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.30801688 |
32 | cellular protein complex disassembly (GO:0043624) | 4.28415034 |
33 | deoxyribonucleotide catabolic process (GO:0009264) | 4.21869438 |
34 | translational initiation (GO:0006413) | 4.21806530 |
35 | proteasome assembly (GO:0043248) | 4.20788626 |
36 | ribosomal large subunit biogenesis (GO:0042273) | 4.16726009 |
37 | translation (GO:0006412) | 4.12019199 |
38 | respiratory chain complex IV assembly (GO:0008535) | 4.05869839 |
39 | base-excision repair, AP site formation (GO:0006285) | 4.05691701 |
40 | deoxyribose phosphate catabolic process (GO:0046386) | 4.04684841 |
41 | cytochrome complex assembly (GO:0017004) | 4.02896060 |
42 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.99906606 |
43 | termination of RNA polymerase III transcription (GO:0006386) | 3.99906606 |
44 | pseudouridine synthesis (GO:0001522) | 3.99024182 |
45 | protein targeting to mitochondrion (GO:0006626) | 3.98979626 |
46 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.94719500 |
47 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.94719500 |
48 | cellular component biogenesis (GO:0044085) | 3.90482661 |
49 | protein neddylation (GO:0045116) | 3.86060560 |
50 | establishment of protein localization to mitochondrion (GO:0072655) | 3.76854274 |
51 | DNA deamination (GO:0045006) | 3.75090466 |
52 | protein complex disassembly (GO:0043241) | 3.73864213 |
53 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.73461786 |
54 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.72975231 |
55 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 3.71053476 |
56 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.62628983 |
57 | protein localization to mitochondrion (GO:0070585) | 3.56807791 |
58 | macromolecular complex disassembly (GO:0032984) | 3.55136503 |
59 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.54474846 |
60 | oxidative phosphorylation (GO:0006119) | 3.51579762 |
61 | iron-sulfur cluster assembly (GO:0016226) | 3.49255187 |
62 | metallo-sulfur cluster assembly (GO:0031163) | 3.49255187 |
63 | GTP biosynthetic process (GO:0006183) | 3.43969693 |
64 | rRNA modification (GO:0000154) | 3.43893077 |
65 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.39953466 |
66 | negative regulation of ligase activity (GO:0051352) | 3.39953466 |
67 | 2-deoxyribonucleotide metabolic process (GO:0009394) | 3.36601585 |
68 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.35376802 |
69 | protein targeting to membrane (GO:0006612) | 3.34456088 |
70 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.33682292 |
71 | rRNA processing (GO:0006364) | 3.33236982 |
72 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.33220507 |
73 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.33187776 |
74 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.30827500 |
75 | chromatin remodeling at centromere (GO:0031055) | 3.30586293 |
76 | establishment of integrated proviral latency (GO:0075713) | 3.29558352 |
77 | deoxyribose phosphate metabolic process (GO:0019692) | 3.23563880 |
78 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 3.23008486 |
79 | purine deoxyribonucleotide catabolic process (GO:0009155) | 3.22207881 |
80 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.21170428 |
81 | rRNA metabolic process (GO:0016072) | 3.20003982 |
82 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.17406458 |
83 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.17275550 |
84 | CENP-A containing nucleosome assembly (GO:0034080) | 3.14287613 |
85 | mRNA catabolic process (GO:0006402) | 3.14119387 |
86 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.13490103 |
87 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.11537050 |
88 | spliceosomal snRNP assembly (GO:0000387) | 3.10392923 |
89 | ATP biosynthetic process (GO:0006754) | 3.09018068 |
90 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.08859027 |
91 | establishment of viral latency (GO:0019043) | 3.07513491 |
92 | UTP biosynthetic process (GO:0006228) | 3.05562707 |
93 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.04992267 |
94 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.04992267 |
95 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.04992267 |
96 | DNA strand elongation (GO:0022616) | 3.04303756 |
97 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.03498054 |
98 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.03498054 |
99 | protein maturation by protein folding (GO:0022417) | 3.02517636 |
100 | RNA catabolic process (GO:0006401) | 3.01981064 |
Rank | Gene Set | Z-score |
---|---|---|
1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.37846524 |
2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.08811117 |
3 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 4.00507340 |
4 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.95186422 |
5 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.69259451 |
6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.57119810 |
7 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.53525887 |
8 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.52071200 |
9 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.48865133 |
10 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.39092281 |
11 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.14316876 |
12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.11197399 |
13 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.08119927 |
14 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.94330342 |
15 | E2F7_22180533_ChIP-Seq_HELA_Human | 2.93267098 |
16 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.85291723 |
17 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.78939325 |
18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.59996765 |
19 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.56326675 |
20 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.55834111 |
21 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.48850553 |
22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.43577971 |
23 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.39162458 |
24 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.36328035 |
25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.35974293 |
26 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.28227498 |
27 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.27429257 |
28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.20755453 |
29 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.08354795 |
30 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.08123964 |
31 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.00858742 |
32 | * DCP1A_22483619_ChIP-Seq_HELA_Human | 1.96368848 |
33 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.95800226 |
34 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.92887308 |
35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.89191112 |
36 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.84261773 |
37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.77635390 |
38 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.77428619 |
39 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.75830469 |
40 | * FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.72823550 |
41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.69958760 |
42 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67887306 |
43 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.64448014 |
44 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.59499573 |
45 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.51375725 |
46 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.50577692 |
47 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.48986442 |
48 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.46737562 |
49 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.44694311 |
50 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.41321144 |
51 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.39415560 |
52 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.37101465 |
53 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.34703624 |
54 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.34693656 |
55 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.31879887 |
56 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.30980284 |
57 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.27652781 |
58 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.27431845 |
59 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.26616266 |
60 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.26119681 |
61 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.25672229 |
62 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.24680681 |
63 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.21075196 |
64 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.20287885 |
65 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.18147628 |
66 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.14052436 |
67 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 1.13955228 |
68 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.13316249 |
69 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13241465 |
70 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11844634 |
71 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.11633109 |
72 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.08197908 |
73 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.07904972 |
74 | * DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.07111504 |
75 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.05520343 |
76 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.02389440 |
77 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.99844476 |
78 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 0.99555085 |
79 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.98938837 |
80 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98484781 |
81 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.97387103 |
82 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.96717371 |
83 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.95369863 |
84 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.94762270 |
85 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.94475900 |
86 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93053866 |
87 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.93034219 |
88 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.92205113 |
89 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.92033539 |
90 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.91190939 |
91 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.90636548 |
92 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.88856003 |
93 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.88048237 |
94 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.87943239 |
95 | * VDR_21846776_ChIP-Seq_THP-1_Human | 0.86704361 |
96 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.84933338 |
97 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.84062076 |
98 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.83217084 |
99 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.79502620 |
100 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.77728931 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0009379_abnormal_foot_pigmentation | 5.05982072 |
2 | MP0006292_abnormal_olfactory_placode | 4.15987443 |
3 | MP0008058_abnormal_DNA_repair | 3.49631956 |
4 | MP0003806_abnormal_nucleotide_metabolis | 3.23042079 |
5 | MP0003693_abnormal_embryo_hatching | 3.20405862 |
6 | MP0003186_abnormal_redox_activity | 2.95853500 |
7 | MP0010094_abnormal_chromosome_stability | 2.67647102 |
8 | MP0006036_abnormal_mitochondrial_physio | 2.61559595 |
9 | MP0002653_abnormal_ependyma_morphology | 2.57586875 |
10 | MP0008789_abnormal_olfactory_epithelium | 2.48920577 |
11 | MP0004957_abnormal_blastocyst_morpholog | 2.47192332 |
12 | MP0000372_irregular_coat_pigmentation | 2.32506310 |
13 | MP0003111_abnormal_nucleus_morphology | 2.28044534 |
14 | MP0008877_abnormal_DNA_methylation | 2.26775842 |
15 | MP0003786_premature_aging | 2.25974533 |
16 | MP0004147_increased_porphyrin_level | 2.01356163 |
17 | MP0003718_maternal_effect | 1.93675834 |
18 | MP0008932_abnormal_embryonic_tissue | 1.92053650 |
19 | MP0005394_taste/olfaction_phenotype | 1.89604598 |
20 | MP0005499_abnormal_olfactory_system | 1.89604598 |
21 | MP0003077_abnormal_cell_cycle | 1.87698190 |
22 | MP0005084_abnormal_gallbladder_morpholo | 1.82293700 |
23 | MP0002163_abnormal_gland_morphology | 1.74763142 |
24 | MP0006035_abnormal_mitochondrial_morpho | 1.73922466 |
25 | MP0003136_yellow_coat_color | 1.67486661 |
26 | MP0001905_abnormal_dopamine_level | 1.65497481 |
27 | MP0008007_abnormal_cellular_replicative | 1.58737751 |
28 | MP0001293_anophthalmia | 1.54644354 |
29 | MP0002938_white_spotting | 1.54185382 |
30 | MP0005075_abnormal_melanosome_morpholog | 1.52520309 |
31 | MP0008995_early_reproductive_senescence | 1.43732601 |
32 | MP0002160_abnormal_reproductive_system | 1.42733678 |
33 | MP0006072_abnormal_retinal_apoptosis | 1.41056434 |
34 | MP0003787_abnormal_imprinting | 1.39885790 |
35 | MP0001529_abnormal_vocalization | 1.36832026 |
36 | MP0002095_abnormal_skin_pigmentation | 1.35239212 |
37 | MP0001764_abnormal_homeostasis | 1.31360379 |
38 | MP0003123_paternal_imprinting | 1.30032475 |
39 | MP0005645_abnormal_hypothalamus_physiol | 1.24958881 |
40 | MP0002736_abnormal_nociception_after | 1.24311663 |
41 | MP0005671_abnormal_response_to | 1.20588653 |
42 | MP0002210_abnormal_sex_determination | 1.19962754 |
43 | MP0005389_reproductive_system_phenotype | 1.18186778 |
44 | MP0003011_delayed_dark_adaptation | 1.17913302 |
45 | MP0002837_dystrophic_cardiac_calcinosis | 1.17879685 |
46 | MP0010030_abnormal_orbit_morphology | 1.16278711 |
47 | MP0009333_abnormal_splenocyte_physiolog | 1.15493579 |
48 | MP0008872_abnormal_physiological_respon | 1.14867734 |
49 | MP0000358_abnormal_cell_content/ | 1.14099217 |
50 | MP0004142_abnormal_muscle_tone | 1.13676815 |
51 | MP0002277_abnormal_respiratory_mucosa | 1.11376602 |
52 | MP0008875_abnormal_xenobiotic_pharmacok | 1.09585257 |
53 | MP0001968_abnormal_touch/_nociception | 1.02297846 |
54 | MP0003121_genomic_imprinting | 1.01050073 |
55 | MP0001485_abnormal_pinna_reflex | 1.01023284 |
56 | MP0000049_abnormal_middle_ear | 1.00727455 |
57 | MP0001145_abnormal_male_reproductive | 0.98997803 |
58 | MP0005379_endocrine/exocrine_gland_phen | 0.98021916 |
59 | MP0002638_abnormal_pupillary_reflex | 0.97432878 |
60 | MP0000313_abnormal_cell_death | 0.96841075 |
61 | MP0001929_abnormal_gametogenesis | 0.94801370 |
62 | MP0000653_abnormal_sex_gland | 0.93273229 |
63 | MP0000490_abnormal_crypts_of | 0.91282374 |
64 | MP0005377_hearing/vestibular/ear_phenot | 0.91156531 |
65 | MP0003878_abnormal_ear_physiology | 0.91156531 |
66 | MP0001984_abnormal_olfaction | 0.90872617 |
67 | MP0002019_abnormal_tumor_incidence | 0.90714897 |
68 | MP0001986_abnormal_taste_sensitivity | 0.90077451 |
69 | MP0001188_hyperpigmentation | 0.89776960 |
70 | MP0009697_abnormal_copulation | 0.88968381 |
71 | MP0002148_abnormal_hypersensitivity_rea | 0.87829749 |
72 | MP0002102_abnormal_ear_morphology | 0.86032595 |
73 | MP0001119_abnormal_female_reproductive | 0.85964094 |
74 | MP0003315_abnormal_perineum_morphology | 0.85454693 |
75 | MP0005636_abnormal_mineral_homeostasis | 0.84768301 |
76 | MP0000631_abnormal_neuroendocrine_gland | 0.83336082 |
77 | MP0005174_abnormal_tail_pigmentation | 0.82093356 |
78 | MP0004133_heterotaxia | 0.81961220 |
79 | MP0001919_abnormal_reproductive_system | 0.78948554 |
80 | MP0005646_abnormal_pituitary_gland | 0.78734916 |
81 | MP0002132_abnormal_respiratory_system | 0.78659531 |
82 | MP0005410_abnormal_fertilization | 0.78173428 |
83 | MP0006276_abnormal_autonomic_nervous | 0.77861191 |
84 | MP0001853_heart_inflammation | 0.74573186 |
85 | MP0002138_abnormal_hepatobiliary_system | 0.72221075 |
86 | MP0005551_abnormal_eye_electrophysiolog | 0.71843983 |
87 | MP0001881_abnormal_mammary_gland | 0.68953103 |
88 | MP0000350_abnormal_cell_proliferation | 0.68162129 |
89 | MP0000689_abnormal_spleen_morphology | 0.67208965 |
90 | MP0003698_abnormal_male_reproductive | 0.66267469 |
91 | MP0005332_abnormal_amino_acid | 0.66188701 |
92 | MP0002429_abnormal_blood_cell | 0.62429619 |
93 | MP0001727_abnormal_embryo_implantation | 0.62395520 |
94 | MP0005397_hematopoietic_system_phenotyp | 0.62243187 |
95 | MP0001545_abnormal_hematopoietic_system | 0.62243187 |
96 | MP0009765_abnormal_xenobiotic_induced | 0.61902197 |
97 | MP0005253_abnormal_eye_physiology | 0.60437614 |
98 | MP0001835_abnormal_antigen_presentation | 0.60050863 |
99 | MP0008873_increased_physiological_sensi | 0.58963912 |
100 | MP0005220_abnormal_exocrine_pancreas | 0.58711814 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Acute necrotizing encephalopathy (HP:0006965) | 5.96334511 |
2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.71544673 |
3 | Mitochondrial inheritance (HP:0001427) | 5.44209537 |
4 | Acute encephalopathy (HP:0006846) | 5.37919273 |
5 | Hepatocellular necrosis (HP:0001404) | 5.04285737 |
6 | Increased CSF lactate (HP:0002490) | 4.81704562 |
7 | Progressive macrocephaly (HP:0004481) | 4.78568849 |
8 | Hepatic necrosis (HP:0002605) | 4.53629328 |
9 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.42350302 |
10 | Reticulocytopenia (HP:0001896) | 4.28844412 |
11 | Increased hepatocellular lipid droplets (HP:0006565) | 4.19563341 |
12 | Abnormal number of erythroid precursors (HP:0012131) | 4.18810609 |
13 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.10018852 |
14 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.10018852 |
15 | Increased intramyocellular lipid droplets (HP:0012240) | 4.00868765 |
16 | Lipid accumulation in hepatocytes (HP:0006561) | 3.98996849 |
17 | Cerebral edema (HP:0002181) | 3.95171410 |
18 | Renal Fanconi syndrome (HP:0001994) | 3.71115509 |
19 | Increased muscle lipid content (HP:0009058) | 3.53101585 |
20 | 3-Methylglutaconic aciduria (HP:0003535) | 3.49437551 |
21 | Lactic acidosis (HP:0003128) | 3.41254797 |
22 | Macrocytic anemia (HP:0001972) | 3.38059768 |
23 | Increased serum lactate (HP:0002151) | 3.36965423 |
24 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.34024435 |
25 | Exercise intolerance (HP:0003546) | 3.12047771 |
26 | Respiratory failure (HP:0002878) | 3.07839232 |
27 | Hyperglycinemia (HP:0002154) | 3.01689800 |
28 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.98917531 |
29 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.85265936 |
30 | Aplastic anemia (HP:0001915) | 2.83096287 |
31 | Microvesicular hepatic steatosis (HP:0001414) | 2.74250746 |
32 | Exertional dyspnea (HP:0002875) | 2.73279696 |
33 | Pallor (HP:0000980) | 2.67933356 |
34 | Colon cancer (HP:0003003) | 2.66816710 |
35 | Optic disc pallor (HP:0000543) | 2.65344394 |
36 | Type I transferrin isoform profile (HP:0003642) | 2.61926033 |
37 | Leukodystrophy (HP:0002415) | 2.61880925 |
38 | Respiratory difficulties (HP:0002880) | 2.55392393 |
39 | Lethargy (HP:0001254) | 2.50302855 |
40 | Pancytopenia (HP:0001876) | 2.35141872 |
41 | Cleft eyelid (HP:0000625) | 2.30547068 |
42 | Microretrognathia (HP:0000308) | 2.30544661 |
43 | Dicarboxylic aciduria (HP:0003215) | 2.29331286 |
44 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.29331286 |
45 | Multiple enchondromatosis (HP:0005701) | 2.27073901 |
46 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.26295266 |
47 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.26295266 |
48 | Abnormal protein glycosylation (HP:0012346) | 2.26295266 |
49 | Abnormal glycosylation (HP:0012345) | 2.26295266 |
50 | Absent thumb (HP:0009777) | 2.25240672 |
51 | Abnormality of midbrain morphology (HP:0002418) | 2.22895078 |
52 | Molar tooth sign on MRI (HP:0002419) | 2.22895078 |
53 | CNS demyelination (HP:0007305) | 2.19305772 |
54 | Methylmalonic aciduria (HP:0012120) | 2.18113123 |
55 | Abnormality of renal resorption (HP:0011038) | 2.16793308 |
56 | Pancreatic fibrosis (HP:0100732) | 2.13467267 |
57 | Increased serum pyruvate (HP:0003542) | 2.12951844 |
58 | Emotional lability (HP:0000712) | 2.09756747 |
59 | Progressive microcephaly (HP:0000253) | 2.04729730 |
60 | Abnormality of alanine metabolism (HP:0010916) | 1.96205449 |
61 | Hyperalaninemia (HP:0003348) | 1.96205449 |
62 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.96205449 |
63 | Testicular atrophy (HP:0000029) | 1.95304222 |
64 | Glycosuria (HP:0003076) | 1.94865417 |
65 | Abnormality of urine glucose concentration (HP:0011016) | 1.94865417 |
66 | Generalized aminoaciduria (HP:0002909) | 1.93832635 |
67 | Abnormality of serum amino acid levels (HP:0003112) | 1.90711733 |
68 | Pancreatic cysts (HP:0001737) | 1.89350402 |
69 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.86493820 |
70 | Oral leukoplakia (HP:0002745) | 1.83927668 |
71 | Thrombocytosis (HP:0001894) | 1.83387328 |
72 | Cerebral hypomyelination (HP:0006808) | 1.83175129 |
73 | Cerebral palsy (HP:0100021) | 1.82072455 |
74 | Degeneration of anterior horn cells (HP:0002398) | 1.80104718 |
75 | Abnormality of the anterior horn cell (HP:0006802) | 1.80104718 |
76 | Hyperphosphaturia (HP:0003109) | 1.79205787 |
77 | Methylmalonic acidemia (HP:0002912) | 1.78404364 |
78 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 1.77605704 |
79 | Abnormality of glycolysis (HP:0004366) | 1.77486769 |
80 | Reduced antithrombin III activity (HP:0001976) | 1.76304845 |
81 | Medial flaring of the eyebrow (HP:0010747) | 1.75601552 |
82 | Hyperglycinuria (HP:0003108) | 1.75286271 |
83 | X-linked dominant inheritance (HP:0001423) | 1.74837779 |
84 | Rough bone trabeculation (HP:0100670) | 1.74783191 |
85 | Sclerocornea (HP:0000647) | 1.73889648 |
86 | Myokymia (HP:0002411) | 1.73683961 |
87 | Triphalangeal thumb (HP:0001199) | 1.72050168 |
88 | True hermaphroditism (HP:0010459) | 1.70271261 |
89 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.67555042 |
90 | Abnormality of glycine metabolism (HP:0010895) | 1.67555042 |
91 | Agammaglobulinemia (HP:0004432) | 1.67360948 |
92 | Neutropenia (HP:0001875) | 1.66541116 |
93 | Blindness (HP:0000618) | 1.63268324 |
94 | Septo-optic dysplasia (HP:0100842) | 1.62614162 |
95 | Gliosis (HP:0002171) | 1.62116673 |
96 | Horseshoe kidney (HP:0000085) | 1.59983029 |
97 | Abnormality of the labia minora (HP:0012880) | 1.59041070 |
98 | Cellular immunodeficiency (HP:0005374) | 1.58935640 |
99 | Vomiting (HP:0002013) | 1.58100758 |
100 | Muscle fiber atrophy (HP:0100295) | 1.56107161 |
Rank | Gene Set | Z-score |
---|---|---|
1 | VRK2 | 5.30285968 |
2 | NME2 | 4.14874614 |
3 | BCKDK | 3.74908135 |
4 | TESK2 | 3.44558879 |
5 | STK16 | 3.43150724 |
6 | BUB1 | 2.98368585 |
7 | CDC7 | 2.94400500 |
8 | ZAK | 2.82725646 |
9 | KDR | 2.79208654 |
10 | VRK1 | 2.59374120 |
11 | TLK1 | 2.46355213 |
12 | CDK19 | 2.35958989 |
13 | PIM2 | 2.30095883 |
14 | NUAK1 | 2.06588692 |
15 | ARAF | 1.99794368 |
16 | SRPK1 | 1.73896496 |
17 | MAP4K2 | 1.71564037 |
18 | TESK1 | 1.64138015 |
19 | DYRK2 | 1.60978612 |
20 | MAP3K11 | 1.59665819 |
21 | LIMK1 | 1.55689531 |
22 | ABL2 | 1.49582318 |
23 | NME1 | 1.38330507 |
24 | AURKA | 1.33891847 |
25 | SCYL2 | 1.31129393 |
26 | PBK | 1.29160448 |
27 | NEK1 | 1.23700192 |
28 | PDK2 | 1.23393476 |
29 | PLK4 | 1.11016569 |
30 | RPS6KA5 | 1.10727409 |
31 | PLK1 | 1.07493992 |
32 | CSNK1G3 | 1.06210136 |
33 | TAF1 | 1.05946659 |
34 | BMPR1B | 1.03916129 |
35 | ATR | 0.97222617 |
36 | AURKB | 0.97213695 |
37 | MST4 | 0.94313445 |
38 | DAPK1 | 0.88291433 |
39 | DAPK3 | 0.88153282 |
40 | MAP2K7 | 0.87670939 |
41 | CSNK1G2 | 0.86429085 |
42 | LRRK2 | 0.86104123 |
43 | PLK3 | 0.81750945 |
44 | CHEK2 | 0.80630365 |
45 | DYRK3 | 0.80028678 |
46 | GRK1 | 0.79356028 |
47 | WNK3 | 0.78469241 |
48 | CDK8 | 0.77669001 |
49 | CSNK1G1 | 0.77451278 |
50 | MAP4K1 | 0.74583575 |
51 | BRAF | 0.70372496 |
52 | TRIM28 | 0.69284236 |
53 | CSNK2A2 | 0.69191231 |
54 | CSNK2A1 | 0.68961287 |
55 | TTK | 0.67845689 |
56 | RPS6KA4 | 0.65407179 |
57 | KIT | 0.60546815 |
58 | CSNK1A1L | 0.60082532 |
59 | MAP3K12 | 0.59462377 |
60 | PAK1 | 0.58440049 |
61 | ILK | 0.58439170 |
62 | PRKCI | 0.58075384 |
63 | ADRBK2 | 0.57671427 |
64 | IKBKB | 0.57609403 |
65 | PRKCQ | 0.55692726 |
66 | PIM1 | 0.55157093 |
67 | OXSR1 | 0.54298569 |
68 | EIF2AK1 | 0.52859813 |
69 | TAOK3 | 0.50071263 |
70 | CCNB1 | 0.46892298 |
71 | CDK7 | 0.46750079 |
72 | TXK | 0.46468550 |
73 | FLT3 | 0.43494624 |
74 | RPS6KB2 | 0.43167087 |
75 | INSRR | 0.41805068 |
76 | PASK | 0.40761902 |
77 | CSF1R | 0.39362799 |
78 | STK4 | 0.39087295 |
79 | TBK1 | 0.37017019 |
80 | ATM | 0.36296878 |
81 | CHEK1 | 0.35990879 |
82 | CSNK1A1 | 0.35841776 |
83 | TAOK2 | 0.33460971 |
84 | NEK2 | 0.32809082 |
85 | EIF2AK3 | 0.32513928 |
86 | GRK5 | 0.31905073 |
87 | BRSK1 | 0.31877659 |
88 | MUSK | 0.31680855 |
89 | TIE1 | 0.31658093 |
90 | PRKCG | 0.31444380 |
91 | TEC | 0.30888497 |
92 | MKNK1 | 0.30411680 |
93 | MAP3K8 | 0.29410940 |
94 | TNK2 | 0.28425707 |
95 | CDK11A | 0.28412842 |
96 | CDK14 | 0.27917755 |
97 | MAPKAPK3 | 0.27098695 |
98 | IKBKE | 0.25211792 |
99 | LYN | 0.24848370 |
100 | MAPKAPK5 | 0.24429181 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Ribosome_Homo sapiens_hsa03010 | 5.10542308 |
2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 4.21934875 |
3 | Proteasome_Homo sapiens_hsa03050 | 3.89503052 |
4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.70092909 |
5 | DNA replication_Homo sapiens_hsa03030 | 3.35401972 |
6 | RNA polymerase_Homo sapiens_hsa03020 | 2.96337601 |
7 | Mismatch repair_Homo sapiens_hsa03430 | 2.83226165 |
8 | Huntingtons disease_Homo sapiens_hsa05016 | 2.68957325 |
9 | Base excision repair_Homo sapiens_hsa03410 | 2.68390933 |
10 | Homologous recombination_Homo sapiens_hsa03440 | 2.40981953 |
11 | Alzheimers disease_Homo sapiens_hsa05010 | 2.33843659 |
12 | Protein export_Homo sapiens_hsa03060 | 2.22839535 |
13 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.13381342 |
14 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.12142709 |
15 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.11346419 |
16 | Spliceosome_Homo sapiens_hsa03040 | 1.92889937 |
17 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.79681916 |
18 | Sulfur relay system_Homo sapiens_hsa04122 | 1.77086584 |
19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.65455343 |
20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.64828311 |
21 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.57675798 |
22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.48691127 |
23 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.48354591 |
24 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.46141180 |
25 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.44978618 |
26 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.38462956 |
27 | RNA degradation_Homo sapiens_hsa03018 | 1.29043866 |
28 | RNA transport_Homo sapiens_hsa03013 | 1.27882922 |
29 | Purine metabolism_Homo sapiens_hsa00230 | 1.25638878 |
30 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.18411524 |
31 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.16541068 |
32 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.14678227 |
33 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.09876204 |
34 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.09027946 |
35 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.08945528 |
36 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.06712237 |
37 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.03347667 |
38 | Basal transcription factors_Homo sapiens_hsa03022 | 1.02066097 |
39 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.98255872 |
40 | Asthma_Homo sapiens_hsa05310 | 0.95010409 |
41 | Peroxisome_Homo sapiens_hsa04146 | 0.91949926 |
42 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.91492644 |
43 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.90565160 |
44 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.89509517 |
45 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.87563819 |
46 | Metabolic pathways_Homo sapiens_hsa01100 | 0.85160247 |
47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.79200219 |
48 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.75981463 |
49 | Carbon metabolism_Homo sapiens_hsa01200 | 0.72674772 |
50 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.72496236 |
51 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.71302351 |
52 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.69570333 |
53 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.66154439 |
54 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.61347965 |
55 | Allograft rejection_Homo sapiens_hsa05330 | 0.59433644 |
56 | Cell cycle_Homo sapiens_hsa04110 | 0.57773672 |
57 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.55728512 |
58 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.53775528 |
59 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.53740769 |
60 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.53404547 |
61 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.53369004 |
62 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.52685300 |
63 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.49570426 |
64 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.48874599 |
65 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.48485874 |
66 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.46647310 |
67 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.46111887 |
68 | Phototransduction_Homo sapiens_hsa04744 | 0.45138341 |
69 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.44040463 |
70 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.43538629 |
71 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.43410563 |
72 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.42695419 |
73 | Alcoholism_Homo sapiens_hsa05034 | 0.39670609 |
74 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.39411508 |
75 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.37818570 |
76 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.37091339 |
77 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.36617170 |
78 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.35152783 |
79 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.35089974 |
80 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.34971889 |
81 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.34343020 |
82 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.34207152 |
83 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.33652299 |
84 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.33651182 |
85 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.31920839 |
86 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.31676523 |
87 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.31033149 |
88 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.30430126 |
89 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.30208148 |
90 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.29123876 |
91 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.26066041 |
92 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.26022541 |
93 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.25946738 |
94 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.25819270 |
95 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.25264963 |
96 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.23614773 |
97 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.22236600 |
98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.20858754 |
99 | Galactose metabolism_Homo sapiens_hsa00052 | 0.20803034 |
100 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.20795892 |