ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	oocyte development (GO:0048599)	9.53290372
2	protein kinase C signaling (GO:0070528)	8.55046228
3	positive regulation of humoral immune response (GO:0002922)	7.97681969
4	negative regulation of reproductive process (GO:2000242)	7.80784861
5	meiotic cell cycle (GO:0051321)	7.61850318
6	piRNA metabolic process (GO:0034587)	7.60393760
7	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	7.59202327
8	DNA methylation involved in gamete generation (GO:0043046)	7.03606852
9	regulation of meiosis I (GO:0060631)	6.85109306
10	reproduction (GO:0000003)	6.80389203
11	female gamete generation (GO:0007292)	6.76706899
12	regulation of histone H3-K9 methylation (GO:0051570)	6.53449847
13	retinal cone cell development (GO:0046549)	6.29880167
14	citrulline biosynthetic process (GO:0019240)	6.29280100
15	positive regulation of histone H3-K4 methylation (GO:0051571)	6.06102477
16	regulation of steroid hormone secretion (GO:2000831)	5.91400587
17	binding of sperm to zona pellucida (GO:0007339)	5.88527910
18	regulation of hypersensitivity (GO:0002883)	5.63146049
19	negative regulation of histone methylation (GO:0031061)	5.52375550
20	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	5.43382873
21	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	5.43382873
22	positive regulation of mitotic sister chromatid separation (GO:1901970)	5.43382873
23	regulation of phospholipid biosynthetic process (GO:0071071)	5.10938936
24	regulation of cell maturation (GO:1903429)	5.01815533
25	fertilization (GO:0009566)	4.96361149
26	gene silencing by RNA (GO:0031047)	4.92975556
27	regulation of calcium ion-dependent exocytosis (GO:0017158)	4.74104803
28	single fertilization (GO:0007338)	4.70269781
29	protein localization to kinetochore (GO:0034501)	4.63381973
30	positive regulation of gastrulation (GO:2000543)	4.62594178
31	sperm-egg recognition (GO:0035036)	4.52961344
32	positive regulation of reproductive process (GO:2000243)	4.52653635
33	positive regulation of chromosome segregation (GO:0051984)	4.45419854
34	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.42229645
35	mitotic chromosome condensation (GO:0007076)	4.41109878
36	protein localization to chromosome, centromeric region (GO:0071459)	4.34267303
37	primitive streak formation (GO:0090009)	4.33849481
38	glycine transport (GO:0015816)	4.23408583
39	centriole replication (GO:0007099)	4.19564670
40	regulation of reproductive process (GO:2000241)	4.17430606
41	DNA alkylation (GO:0006305)	4.10173114
42	DNA methylation (GO:0006306)	4.10173114
43	positive regulation of histone methylation (GO:0031062)	3.94283124
44	synapsis (GO:0007129)	3.92001173
45	synaptonemal complex assembly (GO:0007130)	3.88129891
46	establishment of chromosome localization (GO:0051303)	3.87839196
47	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.85132387
48	mitotic metaphase plate congression (GO:0007080)	3.79498280
49	citrulline metabolic process (GO:0000052)	3.76321844
50	regulation of histone H3-K4 methylation (GO:0051569)	3.70798310
51	regulation of meiosis (GO:0040020)	3.70326881
52	regulation of steroid hormone biosynthetic process (GO:0090030)	3.70077696
53	cell-cell recognition (GO:0009988)	3.65863876
54	regulation of chromatin silencing (GO:0031935)	3.63499335
55	male meiosis I (GO:0007141)	3.62625521
56	chromosome organization involved in meiosis (GO:0070192)	3.57456501
57	protein localization to chromosome (GO:0034502)	3.55238082
58	phosphatidylinositol dephosphorylation (GO:0046856)	3.47541952
59	interkinetic nuclear migration (GO:0022027)	3.44312135
60	male meiosis (GO:0007140)	3.42576613
61	oogenesis (GO:0048477)	3.42416889
62	synaptonemal complex organization (GO:0070193)	3.41298192
63	gene silencing (GO:0016458)	3.38267856
64	regulation of histone methylation (GO:0031060)	3.36497465
65	stress granule assembly (GO:0034063)	3.34940033
66	negative regulation of cAMP-mediated signaling (GO:0043951)	3.32025693
67	somite rostral/caudal axis specification (GO:0032525)	3.31481304
68	negative regulation of histone modification (GO:0031057)	3.25961478
69	labyrinthine layer development (GO:0060711)	3.25074586
70	phospholipid dephosphorylation (GO:0046839)	3.22125124
71	N-terminal protein amino acid acetylation (GO:0006474)	3.20912612
72	regulation of corticosteroid hormone secretion (GO:2000846)	3.19393996
73	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.18163221
74	attachment of spindle microtubules to kinetochore (GO:0008608)	3.12101287
75	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.11524946
76	meiotic cell cycle process (GO:1903046)	3.11472028
77	phosphorelay signal transduction system (GO:0000160)	3.07537425
78	meiosis I (GO:0007127)	3.07404707
79	CENP-A containing nucleosome assembly (GO:0034080)	3.07375868
80	neuron fate determination (GO:0048664)	3.06120618
81	meiotic nuclear division (GO:0007126)	3.04551907
82	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.04158535
83	metaphase plate congression (GO:0051310)	3.03685295
84	regulation of spindle organization (GO:0090224)	3.03040948
85	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.02268507
86	regulation of meiotic cell cycle (GO:0051445)	3.01997348
87	DNA methylation or demethylation (GO:0044728)	3.00901481
88	peptidyl-arginine modification (GO:0018195)	2.99899837
89	histone H3-K9 demethylation (GO:0033169)	2.99261516
90	regulation of chromatin binding (GO:0035561)	2.96135548
91	negative regulation of hormone biosynthetic process (GO:0032353)	2.96130076
92	relaxation of smooth muscle (GO:0044557)	2.96100479
93	regulation of cell cycle G2/M phase transition (GO:1902749)	2.94999993
94	histone H3-K4 trimethylation (GO:0080182)	2.94709995
95	DNA replication checkpoint (GO:0000076)	2.94327273
96	DNA damage induced protein phosphorylation (GO:0006975)	2.89790382
97	regulation of acrosome reaction (GO:0060046)	13.1383852
98	regulation of female gonad development (GO:2000194)	12.8458110
99	regulation of DNA methylation (GO:0044030)	10.2361366
100	multicellular organism reproduction (GO:0032504)	10.1465431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.47075330
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	4.79693547
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.83584242
4	E2F7_22180533_ChIP-Seq_HELA_Human	2.90725527
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61339388
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.48024019
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.48024019
8	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.48024019
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.45961844
10	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.42730675
11	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.09401196
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.06344607
13	EZH2_22144423_ChIP-Seq_EOC_Human	16.7116412
14	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92170616
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.87816923
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.83712005
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.72556020
18	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.62688518
19	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.55958430
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.54029995
21	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.44661114
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.40923794
23	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.38487117
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32802364
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.32295459
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.31060333
27	AR_21909140_ChIP-Seq_LNCAP_Human	1.29392285
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19550281
29	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.16194196
30	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.15480593
31	TCF4_23295773_ChIP-Seq_U87_Human	1.13126294
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11693101
33	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10186625
34	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.08154961
35	CBP_20019798_ChIP-Seq_JUKART_Human	1.07056629
36	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07056629
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05004496
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05004496
39	IRF1_19129219_ChIP-ChIP_H3396_Human	0.99607031
40	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.99069506
41	AR_25329375_ChIP-Seq_VCAP_Human	0.98667834
42	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98179465
43	GF1_26923725_Chip-Seq_HPCs_Mouse	0.95557152
44	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94568889
45	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94486813
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.92380650
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.92370681
48	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.92263656
49	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91981837
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.91280435
51	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.90984673
52	RUNX2_22187159_ChIP-Seq_PCA_Human	0.89923013
53	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.88461393
54	STAT3_23295773_ChIP-Seq_U87_Human	0.86753287
55	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.85837681
56	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.84644460
57	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.84118014
58	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.82324013
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.80935697
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.80248171
61	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.79816456
62	TP53_16413492_ChIP-PET_HCT116_Human	0.79570776
63	CBP_21632823_ChIP-Seq_H3396_Human	0.79204070
64	KLF4_19829295_ChIP-Seq_ESCs_Human	0.78133468
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.77031105
66	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.76495511
67	EWS_26573619_Chip-Seq_HEK293_Human	0.76142726
68	DROSHA_22980978_ChIP-Seq_HELA_Human	0.75800105
69	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.74656866
70	HTT_18923047_ChIP-ChIP_STHdh_Human	0.74524072
71	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.74245974
72	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.71323922
73	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.71129071
74	P300_19829295_ChIP-Seq_ESCs_Human	0.70858408
75	SMRT_27268052_Chip-Seq_Bcells_Human	0.70758915
76	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.69855456
77	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.69580131
78	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.67818819
79	AHR_22903824_ChIP-Seq_MCF-7_Human	0.67719727
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.66263222
81	TP53_22573176_ChIP-Seq_HFKS_Human	0.66142335
82	REST_21632747_ChIP-Seq_MESCs_Mouse	0.65753875
83	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.65424207
84	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.65149187
85	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.63616264
86	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.61733365
87	CDX2_22108803_ChIP-Seq_LS180_Human	0.61602542
88	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.61470055
89	BCAT_22108803_ChIP-Seq_LS180_Human	0.59443122
90	VDR_22108803_ChIP-Seq_LS180_Human	0.58722915
91	OCT4_19829295_ChIP-Seq_ESCs_Human	0.58229908
92	ZNF274_21170338_ChIP-Seq_K562_Hela	0.57843680
93	RXR_22108803_ChIP-Seq_LS180_Human	0.57841605
94	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.57455836
95	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.57267076
96	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.56008961
97	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.55728738
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.55675133
99	TAF15_26573619_Chip-Seq_HEK293_Human	0.55113104
100	GATA3_26560356_Chip-Seq_TH1_Human	0.54568941

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	9.41326889
2	MP0008877_abnormal_DNA_methylation	4.79912423
3	MP0006292_abnormal_olfactory_placode	4.29025895
4	MP0008789_abnormal_olfactory_epithelium	4.12664575
5	MP0005499_abnormal_olfactory_system	3.64206388
6	MP0005394_taste/olfaction_phenotype	3.64206388
7	MP0005395_other_phenotype	3.63793799
8	MP0002139_abnormal_hepatobiliary_system	3.51238475
9	MP0003890_abnormal_embryonic-extraembry	3.06089719
10	MP0003699_abnormal_female_reproductive	2.98772792
11	MP0002138_abnormal_hepatobiliary_system	2.88435338
12	MP0008057_abnormal_DNA_replication	2.52343233
13	MP0001929_abnormal_gametogenesis	2.50704704
14	MP0003693_abnormal_embryo_hatching	2.43294058
15	MP0010030_abnormal_orbit_morphology	2.35862185
16	MP0005360_urolithiasis	2.30877047
17	MP0010234_abnormal_vibrissa_follicle	2.28480899
18	MP0002234_abnormal_pharynx_morphology	2.27892728
19	MP0002210_abnormal_sex_determination	2.15641723
20	MP0003183_abnormal_peptide_metabolism	1.96657221
21	MP0003950_abnormal_plasma_membrane	1.95298763
22	MP0003879_abnormal_hair_cell	1.93785599
23	MP0000653_abnormal_sex_gland	1.89551027
24	MP0002161_abnormal_fertility/fecundity	1.89037729
25	MP0003077_abnormal_cell_cycle	1.88069905
26	MP0001119_abnormal_female_reproductive	1.82748465
27	MP0005410_abnormal_fertilization	1.81103201
28	MP0008058_abnormal_DNA_repair	1.72112301
29	MP0010094_abnormal_chromosome_stability	1.71325196
30	MP0000566_synostosis	1.59265271
31	MP0003252_abnormal_bile_duct	1.58671616
32	MP0010307_abnormal_tumor_latency	1.51577868
33	MP0001730_embryonic_growth_arrest	1.49565777
34	MP0003111_abnormal_nucleus_morphology	1.44866241
35	MP0005389_reproductive_system_phenotype	1.38396506
36	MP0010368_abnormal_lymphatic_system	1.38273092
37	MP0003121_genomic_imprinting	1.37981512
38	MP0002160_abnormal_reproductive_system	1.30872980
39	MP0001293_anophthalmia	1.25473624
40	MP0005647_abnormal_sex_gland	1.23515778
41	MP0009840_abnormal_foam_cell	1.23060037
42	MP0001145_abnormal_male_reproductive	1.22825805
43	MP0000631_abnormal_neuroendocrine_gland	1.14849805
44	MP0000762_abnormal_tongue_morphology	1.11646772
45	MP0001984_abnormal_olfaction	1.11474584
46	MP0008932_abnormal_embryonic_tissue	1.09125356
47	MP0005646_abnormal_pituitary_gland	1.08992156
48	MP0003698_abnormal_male_reproductive	1.08278430
49	MP0001672_abnormal_embryogenesis/_devel	1.05043986
50	MP0005380_embryogenesis_phenotype	1.05043986
51	MP0000427_abnormal_hair_cycle	1.04566458
52	MP0001919_abnormal_reproductive_system	1.03989982
53	MP0010678_abnormal_skin_adnexa	1.03873337
54	MP0002233_abnormal_nose_morphology	1.03095755
55	MP0003119_abnormal_digestive_system	0.98273168
56	MP0005085_abnormal_gallbladder_physiolo	0.95482503
57	MP0001666_abnormal_nutrient_absorption	0.93807154
58	MP0001986_abnormal_taste_sensitivity	0.91748132
59	MP0002272_abnormal_nervous_system	0.86380097
60	MP0001664_abnormal_digestion	0.83939415
61	MP0003868_abnormal_feces_composition	0.80735238
62	MP0000350_abnormal_cell_proliferation	0.79901784
63	MP0005551_abnormal_eye_electrophysiolog	0.72016839
64	MP0002089_abnormal_postnatal_growth/wei	0.68498616
65	MP0001324_abnormal_eye_pigmentation	0.68342678
66	MP0003959_abnormal_lean_body	0.62444557
67	MP0002928_abnormal_bile_duct	0.62430601
68	MP0004142_abnormal_muscle_tone	0.59316342
69	MP0002084_abnormal_developmental_patter	0.57356610
70	MP0003136_yellow_coat_color	0.56885337
71	MP0000383_abnormal_hair_follicle	0.56481921
72	MP0000049_abnormal_middle_ear	0.52985545
73	MP0000678_abnormal_parathyroid_gland	0.52710400
74	MP0000733_abnormal_muscle_development	0.52398354
75	MP0004957_abnormal_blastocyst_morpholog	0.50928469
76	MP0003935_abnormal_craniofacial_develop	0.48502070
77	MP0003941_abnormal_skin_development	0.47656696
78	MP0006276_abnormal_autonomic_nervous	0.46494872
79	MP0001963_abnormal_hearing_physiology	0.45709161
80	MP0006138_congestive_heart_failure	0.45376253
81	MP0002796_impaired_skin_barrier	0.44959553
82	MP0002085_abnormal_embryonic_tissue	0.44718113
83	MP0003984_embryonic_growth_retardation	0.40041872
84	MP0001502_abnormal_circadian_rhythm	0.39437335
85	MP0000377_abnormal_hair_follicle	0.38640024
86	MP0005076_abnormal_cell_differentiation	0.37527929
87	MP0002396_abnormal_hematopoietic_system	0.37462158
88	MP0000015_abnormal_ear_pigmentation	0.37375470
89	MP0001697_abnormal_embryo_size	0.37338158
90	MP0008995_early_reproductive_senescence	0.37332269
91	MP0002127_abnormal_cardiovascular_syste	0.36598515
92	MP0005501_abnormal_skin_physiology	0.36448522
93	MP0005075_abnormal_melanosome_morpholog	0.36374152
94	MP0005409_darkened_coat_color	0.36269538
95	MP0002088_abnormal_embryonic_growth/wei	0.36203316
96	MP0003755_abnormal_palate_morphology	0.35515852
97	MP0002090_abnormal_vision	0.35405208
98	MP0005503_abnormal_tendon_morphology	0.33833199
99	MP0005319_abnormal_enzyme/_coenzyme	0.33011248
100	MP0002873_normal_phenotype	0.32315599

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	6.08926127
2	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.67419172
3	Hypoplasia of the fovea (HP:0007750)	5.67419172
4	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	5.56928373
5	Anterior segment dysgenesis (HP:0007700)	5.40208157
6	Abnormality of abdominal situs (HP:0011620)	4.95771651
7	Abdominal situs inversus (HP:0003363)	4.95771651
8	Facial hemangioma (HP:0000329)	4.82360146
9	Impulsivity (HP:0100710)	4.81542960
10	Abnormality of the fovea (HP:0000493)	4.75935184
11	Osteomalacia (HP:0002749)	4.63833468
12	Abnormal gallbladder physiology (HP:0012438)	4.63448366
13	Cholecystitis (HP:0001082)	4.63448366
14	Lip pit (HP:0100267)	4.45774005
15	Papillary thyroid carcinoma (HP:0002895)	4.32706361
16	Oligodactyly (hands) (HP:0001180)	4.25448976
17	Hypophosphatemic rickets (HP:0004912)	4.05013513
18	Infertility (HP:0000789)	4.02407727
19	Septo-optic dysplasia (HP:0100842)	3.97387472
20	Chromsome breakage (HP:0040012)	3.84409997
21	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.71455977
22	Aplasia/Hypoplasia of the macula (HP:0008059)	3.66472510
23	Azoospermia (HP:0000027)	3.63737492
24	Absent septum pellucidum (HP:0001331)	3.38011664
25	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.36589283
26	Male infertility (HP:0003251)	3.34086556
27	Apathy (HP:0000741)	3.29437887
28	Abnormality of the labia minora (HP:0012880)	3.28215919
29	Gonadotropin excess (HP:0000837)	3.27762030
30	Premature ovarian failure (HP:0008209)	3.26720285
31	Hypergonadotropic hypogonadism (HP:0000815)	3.25965166
32	Median cleft lip (HP:0000161)	3.12511937
33	Diminished motivation (HP:0000745)	3.12501163
34	Malnutrition (HP:0004395)	3.09131383
35	Oligodactyly (HP:0012165)	3.07467275
36	Capillary hemangiomas (HP:0005306)	3.02292567
37	Wrist flexion contracture (HP:0001239)	2.97819832
38	Short tibia (HP:0005736)	2.95061850
39	Secondary amenorrhea (HP:0000869)	2.91876299
40	Enlarged penis (HP:0000040)	2.91597186
41	Abnormality of the septum pellucidum (HP:0007375)	2.89037425
42	Fair hair (HP:0002286)	2.82949865
43	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.73142591
44	Abnormal spermatogenesis (HP:0008669)	2.72251319
45	Intrahepatic cholestasis (HP:0001406)	2.68189260
46	Hypokinesia (HP:0002375)	2.67328136
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.61836443
48	Urethral obstruction (HP:0000796)	2.59602733
49	Aplasia of the musculature (HP:0100854)	2.47932415
50	Truncal obesity (HP:0001956)	2.46617866
51	Metaphyseal irregularity (HP:0003025)	2.46596934
52	Spinal cord compression (HP:0002176)	2.46279117
53	Abnormality of the phalanges of the hallux (HP:0010057)	2.38412806
54	Dysmetric saccades (HP:0000641)	2.37709566
55	Thyroid carcinoma (HP:0002890)	2.36171834
56	Bile duct proliferation (HP:0001408)	2.35321304
57	Abnormal biliary tract physiology (HP:0012439)	2.35321304
58	Dysdiadochokinesis (HP:0002075)	2.33987381
59	Stillbirth (HP:0003826)	2.28639390
60	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.28221932
61	Abnormality of the anterior chamber (HP:0000593)	2.24875134
62	Lower limb hyperreflexia (HP:0002395)	2.23564760
63	Pulmonary fibrosis (HP:0002206)	2.23239138
64	Loss of speech (HP:0002371)	2.22335460
65	Myokymia (HP:0002411)	2.18902665
66	Maternal diabetes (HP:0009800)	2.16049110
67	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.15795109
68	Ankle contracture (HP:0006466)	2.15487745
69	Anhidrosis (HP:0000970)	2.14721785
70	Skin pits (HP:0100276)	2.13124180
71	Heterotopia (HP:0002282)	2.12121283
72	Congenital sensorineural hearing impairment (HP:0008527)	2.11544912
73	Bundle branch block (HP:0011710)	2.08270671
74	Abnormal ciliary motility (HP:0012262)	2.07918763
75	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.07899022
76	Abnormality of chromosome stability (HP:0003220)	2.06683052
77	Conjunctival telangiectasia (HP:0000524)	2.04730695
78	Generalized hypopigmentation of hair (HP:0011358)	1.99805786
79	Proximal tubulopathy (HP:0000114)	1.98821387
80	Posterior subcapsular cataract (HP:0007787)	1.97938399
81	Hip contracture (HP:0003273)	1.96058107
82	Abnormality of chromosome segregation (HP:0002916)	1.95376206
83	Shallow orbits (HP:0000586)	1.94792392
84	Abnormal lung lobation (HP:0002101)	1.93995547
85	Meckel diverticulum (HP:0002245)	1.93794615
86	Nephroblastoma (Wilms tumor) (HP:0002667)	1.93270677
87	Abnormality of the preputium (HP:0100587)	1.92449769
88	Cone-rod dystrophy (HP:0000548)	1.89396645
89	Subcapsular cataract (HP:0000523)	1.89078184
90	Hydroureter (HP:0000072)	1.88002139
91	Small intestinal stenosis (HP:0012848)	1.87770082
92	Duodenal stenosis (HP:0100867)	1.87770082
93	Striae distensae (HP:0001065)	1.84804682
94	Gaze-evoked nystagmus (HP:0000640)	1.83397960
95	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.83016209
96	Bicornuate uterus (HP:0000813)	1.82887441
97	Embryonal renal neoplasm (HP:0011794)	1.81968512
98	Abnormality of the ileum (HP:0001549)	1.81551791
99	Limb hypertonia (HP:0002509)	1.81386627
100	Prostate neoplasm (HP:0100787)	1.76369670

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.01121235
2	MAP3K13	5.44869264
3	ARAF	5.33668417
4	CDK12	4.26820550
5	NEK6	3.12494795
6	CDK9	3.07701008
7	TTK	3.01701697
8	BRAF	2.81656042
9	TAOK3	2.75215386
10	STK24	2.71489051
11	MET	2.68656622
12	AURKA	2.53453485
13	MOS	2.32503659
14	NTRK2	2.15693968
15	KSR2	1.73771110
16	CDC7	1.69821066
17	PRKCI	1.66704992
18	RAF1	1.63878461
19	MELK	1.47952826
20	TNIK	1.44934268
21	CDK7	1.34608015
22	PLK1	1.29395575
23	STK3	1.28048306
24	CAMK1D	1.27647273
25	TRIM28	1.22203132
26	EIF2AK3	1.13713020
27	KSR1	1.12645248
28	BRSK1	1.06547637
29	MST4	1.05331751
30	CHEK1	1.00577702
31	NEK9	1.00155106
32	TGFBR1	0.97953198
33	ZAK	0.96326196
34	BRD4	0.94890263
35	WNK1	0.94259997
36	MAP3K8	0.93774304
37	NEK2	0.86577219
38	NUAK1	0.83039868
39	PIM1	0.82847390
40	MARK3	0.82413422
41	PTK2	0.82389345
42	TIE1	0.81913767
43	CDK2	0.80522632
44	EEF2K	0.78908094
45	CAMK1G	0.78465812
46	CSNK1G1	0.77599707
47	CHEK2	0.75573710
48	STK39	0.73441586
49	TNK2	0.72292139
50	MTOR	0.70009515
51	MAPKAPK3	0.69737667
52	CDK19	0.68122468
53	CSNK1D	0.67978338
54	CDK8	0.63581967
55	BMPR1B	0.63477541
56	ATM	0.63284922
57	AURKB	0.62708331
58	MAPK13	0.59691339
59	BUB1	0.58372224
60	CDK1	0.57903136
61	PLK3	0.56040360
62	PRKCZ	0.53742555
63	OXSR1	0.53404422
64	DMPK	0.53066664
65	CSNK1G3	0.52344605
66	PRKG1	0.50739986
67	BRSK2	0.47479195
68	PAK1	0.46627302
69	CDK5	0.42816145
70	PKN1	0.41429375
71	CHUK	0.38976153
72	NTRK3	0.38789147
73	ATR	0.38561525
74	CSNK1A1L	0.35350654
75	CAMK2A	0.34745615
76	CSNK1E	0.34667254
77	GSK3B	0.33050806
78	ACVR1B	0.32344888
79	MAPK1	0.32104140
80	TYRO3	0.31476301
81	PRKACA	0.30652699
82	CSNK1G2	0.30474143
83	PRKACB	0.27655924
84	LRRK2	0.27153742
85	TLK1	0.27121086
86	MAPK10	0.26844662
87	VRK1	0.26260390
88	CAMK4	0.24141965
89	PDK1	0.23753188
90	TRPM7	0.23506018
91	PRKAA1	0.22107679
92	MAP3K7	0.21103480
93	PBK	0.20058981
94	PRKAA2	0.19143193
95	MAPK11	0.18250569
96	MAP3K5	0.17461557
97	AKT2	0.15288321
98	CAMK1	0.14428645
99	CDC42BPA	0.12845390
100	FLT3	0.11780181

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.85098708
2	Ovarian steroidogenesis_Homo sapiens_hsa04913	4.75286084
3	Cell cycle_Homo sapiens_hsa04110	4.44389429
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.51332699
5	Oocyte meiosis_Homo sapiens_hsa04114	3.35939134
6	Caffeine metabolism_Homo sapiens_hsa00232	3.05722965
7	Mismatch repair_Homo sapiens_hsa03430	2.87576161
8	RNA degradation_Homo sapiens_hsa03018	2.77667635
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.75503966
10	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.74466924
11	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.70044233
12	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.19385191
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13559073
14	Homologous recombination_Homo sapiens_hsa03440	2.07401359
15	Base excision repair_Homo sapiens_hsa03410	2.06276177
16	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.00338919
17	Circadian rhythm_Homo sapiens_hsa04710	1.99484556
18	Gap junction_Homo sapiens_hsa04540	1.98929376
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.97071220
20	RNA transport_Homo sapiens_hsa03013	1.85751025
21	DNA replication_Homo sapiens_hsa03030	1.78044591
22	Olfactory transduction_Homo sapiens_hsa04740	1.75405260
23	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.74431831
24	p53 signaling pathway_Homo sapiens_hsa04115	1.72581214
25	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.53940611
26	Thyroid cancer_Homo sapiens_hsa05216	1.45222109
27	Folate biosynthesis_Homo sapiens_hsa00790	1.35359317
28	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.24258211
29	Phototransduction_Homo sapiens_hsa04744	1.20764790
30	ABC transporters_Homo sapiens_hsa02010	1.17435850
31	Nicotine addiction_Homo sapiens_hsa05033	1.16978933
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11125864
33	mRNA surveillance pathway_Homo sapiens_hsa03015	1.05727419
34	mTOR signaling pathway_Homo sapiens_hsa04150	0.98406526
35	GABAergic synapse_Homo sapiens_hsa04727	0.94013669
36	Bile secretion_Homo sapiens_hsa04976	0.92666224
37	RNA polymerase_Homo sapiens_hsa03020	0.88859856
38	Morphine addiction_Homo sapiens_hsa05032	0.84798227
39	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84753269
40	Lysine degradation_Homo sapiens_hsa00310	0.78831150
41	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.75668105
42	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.74378249
43	FoxO signaling pathway_Homo sapiens_hsa04068	0.70753556
44	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64792325
45	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.62360324
46	Adherens junction_Homo sapiens_hsa04520	0.62257603
47	MicroRNAs in cancer_Homo sapiens_hsa05206	0.61340386
48	Long-term depression_Homo sapiens_hsa04730	0.59133710
49	Taste transduction_Homo sapiens_hsa04742	0.55873395
50	Notch signaling pathway_Homo sapiens_hsa04330	0.52787711
51	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49070594
52	ErbB signaling pathway_Homo sapiens_hsa04012	0.46501051
53	Renal cell carcinoma_Homo sapiens_hsa05211	0.44385362
54	Herpes simplex infection_Homo sapiens_hsa05168	0.43782202
55	Purine metabolism_Homo sapiens_hsa00230	0.43359776
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.42133578
57	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.41890964
58	Serotonergic synapse_Homo sapiens_hsa04726	0.41542062
59	Ras signaling pathway_Homo sapiens_hsa04014	0.41254328
60	Wnt signaling pathway_Homo sapiens_hsa04310	0.36598878
61	Phagosome_Homo sapiens_hsa04145	0.36567356
62	Hippo signaling pathway_Homo sapiens_hsa04390	0.34576293
63	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.34121865
64	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.33894162
65	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.33229174
66	cAMP signaling pathway_Homo sapiens_hsa04024	0.30773120
67	HTLV-I infection_Homo sapiens_hsa05166	0.30089484
68	Small cell lung cancer_Homo sapiens_hsa05222	0.28716968
69	Viral carcinogenesis_Homo sapiens_hsa05203	0.28228675
70	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.25310825
71	Huntingtons disease_Homo sapiens_hsa05016	0.24165431
72	Regulation of autophagy_Homo sapiens_hsa04140	0.23979040
73	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.22964466
74	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.22411472
75	Fatty acid elongation_Homo sapiens_hsa00062	0.22311389
76	Endometrial cancer_Homo sapiens_hsa05213	0.21888554
77	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.20972210
78	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.20711793
79	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.20406430
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.19486201
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.19036615
82	Long-term potentiation_Homo sapiens_hsa04720	0.17894123
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.17860110
84	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.17609161
85	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.16795577
86	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.16260606
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.16236667
88	Cholinergic synapse_Homo sapiens_hsa04725	0.16203694
89	Circadian entrainment_Homo sapiens_hsa04713	0.15968991
90	Linoleic acid metabolism_Homo sapiens_hsa00591	0.14595192
91	Melanogenesis_Homo sapiens_hsa04916	0.11032718
92	Prostate cancer_Homo sapiens_hsa05215	0.08701599
93	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.08155407
94	Rap1 signaling pathway_Homo sapiens_hsa04015	0.08149089
95	MAPK signaling pathway_Homo sapiens_hsa04010	0.07761675
96	Arginine biosynthesis_Homo sapiens_hsa00220	0.07129883
97	Pathways in cancer_Homo sapiens_hsa05200	0.06706446
98	Propanoate metabolism_Homo sapiens_hsa00640	0.06559677
99	Influenza A_Homo sapiens_hsa05164	0.06206880
100	Arginine and proline metabolism_Homo sapiens_hsa00330	0.05460780

C11ORF40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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