

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | acrosome reaction (GO:0007340) | 9.19681271 |
| 2 | fusion of sperm to egg plasma membrane (GO:0007342) | 8.99357059 |
| 3 | protein targeting to Golgi (GO:0000042) | 8.49012346 |
| 4 | chromosome condensation (GO:0030261) | 8.22550400 |
| 5 | establishment of protein localization to Golgi (GO:0072600) | 8.12500320 |
| 6 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 7.92611605 |
| 7 | DNA packaging (GO:0006323) | 7.91282595 |
| 8 | microtubule depolymerization (GO:0007019) | 7.28611648 |
| 9 | protein polyglutamylation (GO:0018095) | 7.09614681 |
| 10 | growth hormone receptor signaling pathway (GO:0060396) | 7.05137864 |
| 11 | sperm capacitation (GO:0048240) | 6.98147572 |
| 12 | microtubule polymerization or depolymerization (GO:0031109) | 6.71668431 |
| 13 | plasma membrane fusion (GO:0045026) | 6.71090478 |
| 14 | spermatid development (GO:0007286) | 6.42078172 |
| 15 | spermatid nucleus differentiation (GO:0007289) | 6.28437627 |
| 16 | rRNA methylation (GO:0031167) | 6.27159757 |
| 17 | cellular response to growth hormone stimulus (GO:0071378) | 6.20320494 |
| 18 | single strand break repair (GO:0000012) | 6.10984816 |
| 19 | regulation of activation of Janus kinase activity (GO:0010533) | 6.05371763 |
| 20 | sperm-egg recognition (GO:0035036) | 6.04455672 |
| 21 | centriole replication (GO:0007099) | 6.02846747 |
| 22 | spermatogenesis (GO:0007283) | 5.89830964 |
| 23 | protein localization to Golgi apparatus (GO:0034067) | 5.89582843 |
| 24 | male gamete generation (GO:0048232) | 5.87850476 |
| 25 | centriole assembly (GO:0098534) | 5.87803188 |
| 26 | regulation of centriole replication (GO:0046599) | 5.74033326 |
| 27 | phosphatidylethanolamine biosynthetic process (GO:0006646) | 5.70423548 |
| 28 | negative regulation of inclusion body assembly (GO:0090084) | 5.68116309 |
| 29 | microtubule severing (GO:0051013) | 5.67060256 |
| 30 | multicellular organism reproduction (GO:0032504) | 5.52626528 |
| 31 | binding of sperm to zona pellucida (GO:0007339) | 5.50679009 |
| 32 | gamete generation (GO:0007276) | 5.42356266 |
| 33 | seminiferous tubule development (GO:0072520) | 5.39061567 |
| 34 | calcium ion-dependent exocytosis (GO:0017156) | 5.26556555 |
| 35 | glomerular visceral epithelial cell development (GO:0072015) | 5.24697422 |
| 36 | axonemal dynein complex assembly (GO:0070286) | 5.21745186 |
| 37 | reproduction (GO:0000003) | 5.20324139 |
| 38 | nuclear pore complex assembly (GO:0051292) | 5.19571737 |
| 39 | phosphatidylethanolamine metabolic process (GO:0046337) | 5.19515045 |
| 40 | rRNA modification (GO:0000154) | 5.11651341 |
| 41 | motile cilium assembly (GO:0044458) | 5.10071226 |
| 42 | sexual reproduction (GO:0019953) | 5.07759360 |
| 43 | cell-cell recognition (GO:0009988) | 5.05575533 |
| 44 | response to pheromone (GO:0019236) | 4.95307817 |
| 45 | glomerular epithelial cell development (GO:0072310) | 4.83491339 |
| 46 | microtubule nucleation (GO:0007020) | 4.58796204 |
| 47 | regulation of cilium movement (GO:0003352) | 4.47919915 |
| 48 | single fertilization (GO:0007338) | 4.47242503 |
| 49 | RNA destabilization (GO:0050779) | 4.34657785 |
| 50 | multicellular organismal reproductive process (GO:0048609) | 4.32482425 |
| 51 | regulation of Rab GTPase activity (GO:0032313) | 4.29776854 |
| 52 | positive regulation of Rab GTPase activity (GO:0032851) | 4.29776854 |
| 53 | cilium or flagellum-dependent cell motility (GO:0001539) | 4.29682644 |
| 54 | cell wall macromolecule catabolic process (GO:0016998) | 4.23213335 |
| 55 | musculoskeletal movement (GO:0050881) | 4.19357408 |
| 56 | multicellular organismal movement (GO:0050879) | 4.19357408 |
| 57 | nucleus organization (GO:0006997) | 4.17161205 |
| 58 | fertilization (GO:0009566) | 4.10831033 |
| 59 | positive regulation by symbiont of host defense response (GO:0052509) | 4.02944405 |
| 60 | modulation by symbiont of host defense response (GO:0052031) | 4.02944405 |
| 61 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 4.02944405 |
| 62 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 4.02944405 |
| 63 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 4.02944405 |
| 64 | modulation by symbiont of host immune response (GO:0052553) | 4.02944405 |
| 65 | nuclear pore organization (GO:0006999) | 3.93684882 |
| 66 | regulation of inclusion body assembly (GO:0090083) | 3.92471246 |
| 67 | cell wall macromolecule metabolic process (GO:0044036) | 3.88317038 |
| 68 | germ cell development (GO:0007281) | 3.86940063 |
| 69 | pore complex assembly (GO:0046931) | 3.83685205 |
| 70 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 3.78903322 |
| 71 | chromatin silencing (GO:0006342) | 3.72472944 |
| 72 | cellular process involved in reproduction in multicellular organism (GO:0022412) | 3.72237619 |
| 73 | epithelial cilium movement (GO:0003351) | 3.67039463 |
| 74 | macrophage activation involved in immune response (GO:0002281) | 3.61983566 |
| 75 | regulation of transcription involved in cell fate commitment (GO:0060850) | 3.59292053 |
| 76 | positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568) | 3.48596400 |
| 77 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.45161716 |
| 78 | histone H3-K9 demethylation (GO:0033169) | 3.44277668 |
| 79 | male meiosis I (GO:0007141) | 3.38414803 |
| 80 | response to growth hormone (GO:0060416) | 3.27225564 |
| 81 | negative regulation of Rho protein signal transduction (GO:0035024) | 3.23818032 |
| 82 | cilium movement (GO:0003341) | 3.19089450 |
| 83 | glycerol ether metabolic process (GO:0006662) | 3.17249606 |
| 84 | membrane protein intracellular domain proteolysis (GO:0031293) | 3.14900516 |
| 85 | piRNA metabolic process (GO:0034587) | 3.09256115 |
| 86 | intra-Golgi vesicle-mediated transport (GO:0006891) | 3.07376739 |
| 87 | male meiosis (GO:0007140) | 3.05643849 |
| 88 | regulation of T-helper 2 cell differentiation (GO:0045628) | 2.96594640 |
| 89 | JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | 2.93943295 |
| 90 | protein depolymerization (GO:0051261) | 2.89658284 |
| 91 | ether metabolic process (GO:0018904) | 2.88602501 |
| 92 | cartilage development involved in endochondral bone morphogenesis (GO:0060351) | 2.86323038 |
| 93 | positive regulation of receptor internalization (GO:0002092) | 2.83821390 |
| 94 | regulation of ARF GTPase activity (GO:0032312) | 2.82478467 |
| 95 | DNA methylation involved in gamete generation (GO:0043046) | 2.80197995 |
| 96 | microglial cell activation (GO:0001774) | 2.77738140 |
| 97 | organic cation transport (GO:0015695) | 2.69392785 |
| 98 | DNA conformation change (GO:0071103) | 2.68680022 |
| 99 | regulation of interferon-beta biosynthetic process (GO:0045357) | 2.65045727 |
| 100 | sperm motility (GO:0030317) | 10.3270317 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 5.45656646 |
| 2 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 3.22119571 |
| 3 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.81771420 |
| 4 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.52774901 |
| 5 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.31641059 |
| 6 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 2.31641059 |
| 7 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.24462462 |
| 8 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.16059432 |
| 9 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.87895484 |
| 10 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.87895484 |
| 11 | FUS_26573619_Chip-Seq_HEK293_Human | 1.81997604 |
| 12 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.78211220 |
| 13 | RAC3_21632823_ChIP-Seq_H3396_Human | 1.77627069 |
| 14 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.71919701 |
| 15 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.71786529 |
| 16 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.66719872 |
| 17 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.66124916 |
| 18 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.62840802 |
| 19 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.60229421 |
| 20 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.54298489 |
| 21 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.54143235 |
| 22 | * SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.53139389 |
| 23 | * ERA_21632823_ChIP-Seq_H3396_Human | 1.53077064 |
| 24 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.53045071 |
| 25 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.51646484 |
| 26 | RBPJ_21746931_ChIP-Seq_IB4_Human | 1.48441024 |
| 27 | NFYB_21822215_ChIP-Seq_K562_Human | 1.47191363 |
| 28 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.46885631 |
| 29 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.46369601 |
| 30 | EBNA1_20929547_Chip-Seq_RAJI-cells_Human | 1.44027383 |
| 31 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.41089042 |
| 32 | TAF2_19829295_ChIP-Seq_ESCs_Human | 1.40644768 |
| 33 | TBL1_22424771_ChIP-Seq_293T_Human | 1.40284027 |
| 34 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.40225535 |
| 35 | AR_25329375_ChIP-Seq_VCAP_Human | 1.39967234 |
| 36 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.37069652 |
| 37 | PKCTHETA_26484144_Chip-Seq_BREAST_Human | 1.36941211 |
| 38 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.34753508 |
| 39 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.34381485 |
| 40 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.33654050 |
| 41 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 1.32835234 |
| 42 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.32724268 |
| 43 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.32203028 |
| 44 | TP63_22573176_ChIP-Seq_HFKS_Human | 1.30339248 |
| 45 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 1.30323499 |
| 46 | P68_20966046_ChIP-Seq_HELA_Human | 1.30005871 |
| 47 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 1.29948231 |
| 48 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.29729797 |
| 49 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.29308565 |
| 50 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.25612834 |
| 51 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 1.24839878 |
| 52 | MYC_19829295_ChIP-Seq_ESCs_Human | 1.24732313 |
| 53 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 1.23971156 |
| 54 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.23224432 |
| 55 | NFYA_21822215_ChIP-Seq_K562_Human | 1.23206702 |
| 56 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.22850295 |
| 57 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.22510734 |
| 58 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.21892280 |
| 59 | NANOG_20526341_ChIP-Seq_ESCs_Human | 1.21862260 |
| 60 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.21358829 |
| 61 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 1.18888134 |
| 62 | P300_19829295_ChIP-Seq_ESCs_Human | 1.18210380 |
| 63 | BCOR_27268052_Chip-Seq_Bcells_Human | 1.18192255 |
| 64 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.17833978 |
| 65 | STAT3_23295773_ChIP-Seq_U87_Human | 1.17101100 |
| 66 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 1.16709659 |
| 67 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.16387809 |
| 68 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.16253431 |
| 69 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.15948321 |
| 70 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.14969441 |
| 71 | KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse | 1.13954350 |
| 72 | GATA3_21878914_ChIP-Seq_MCF-7_Human | 1.13238210 |
| 73 | PHF8_20622854_ChIP-Seq_HELA_Human | 1.12997572 |
| 74 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.12479964 |
| 75 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.11918531 |
| 76 | CEBPB_22108803_ChIP-Seq_LS180_Human | 1.11434631 |
| 77 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.11041697 |
| 78 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.09195736 |
| 79 | E2F1_20622854_ChIP-Seq_HELA_Human | 1.08085230 |
| 80 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.07954438 |
| 81 | KLF4_19829295_ChIP-Seq_ESCs_Human | 1.07751008 |
| 82 | GATA1_19941826_ChIP-Seq_K562_Human | 1.06204364 |
| 83 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.05348031 |
| 84 | P63_20808887_ChIP-Seq_KERATINOCYTES_Human | 1.04769787 |
| 85 | FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.04668084 |
| 86 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 1.03300266 |
| 87 | SA1_27219007_Chip-Seq_Bcells_Human | 1.03260897 |
| 88 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.02778573 |
| 89 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.02242753 |
| 90 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 1.01972922 |
| 91 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.01923054 |
| 92 | SMRT_27268052_Chip-Seq_Bcells_Human | 1.01026556 |
| 93 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.00688898 |
| 94 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.98779349 |
| 95 | KLF5_25053715_ChIP-Seq_YYC3_Human | 0.98469337 |
| 96 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.98428403 |
| 97 | KDM2B_26808549_Chip-Seq_REH_Human | 0.98047567 |
| 98 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.97659611 |
| 99 | GF1_26923725_Chip-Seq_HPCs_Mouse | 0.97652743 |
| 100 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.97079369 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005451_abnormal_body_composition | 6.77336033 |
| 2 | MP0005377_hearing/vestibular/ear_phenot | 5.35658954 |
| 3 | MP0003878_abnormal_ear_physiology | 5.35658954 |
| 4 | MP0001348_abnormal_lacrimal_gland | 4.76763367 |
| 5 | MP0003698_abnormal_male_reproductive | 4.00855436 |
| 6 | MP0005670_abnormal_white_adipose | 3.55978610 |
| 7 | MP0001929_abnormal_gametogenesis | 3.50768429 |
| 8 | MP0000678_abnormal_parathyroid_gland | 2.40026146 |
| 9 | MP0005423_abnormal_somatic_nervous | 2.35242933 |
| 10 | MP0005310_abnormal_salivary_gland | 2.29915896 |
| 11 | MP0002161_abnormal_fertility/fecundity | 2.16247886 |
| 12 | MP0005410_abnormal_fertilization | 10.4091552 |
| 13 | MP0001486_abnormal_startle_reflex | 1.81825385 |
| 14 | MP0003646_muscle_fatigue | 1.76175658 |
| 15 | MP0003718_maternal_effect | 1.62321998 |
| 16 | MP0003879_abnormal_hair_cell | 1.60851198 |
| 17 | MP0004859_abnormal_synaptic_plasticity | 1.59526956 |
| 18 | MP0002210_abnormal_sex_determination | 1.53112173 |
| 19 | MP0001485_abnormal_pinna_reflex | 1.48905030 |
| 20 | MP0003011_delayed_dark_adaptation | 1.46208539 |
| 21 | MP0002249_abnormal_larynx_morphology | 1.39755811 |
| 22 | MP0002282_abnormal_trachea_morphology | 1.39286436 |
| 23 | MP0009115_abnormal_fat_cell | 1.36950323 |
| 24 | MP0002132_abnormal_respiratory_system | 1.31373136 |
| 25 | MP0004742_abnormal_vestibular_system | 1.31022802 |
| 26 | MP0001145_abnormal_male_reproductive | 1.25185745 |
| 27 | MP0005379_endocrine/exocrine_gland_phen | 1.22875505 |
| 28 | MP0005248_abnormal_Harderian_gland | 1.21350655 |
| 29 | MP0001765_abnormal_ion_homeostasis | 1.20080518 |
| 30 | MP0008877_abnormal_DNA_methylation | 1.19374278 |
| 31 | MP0000653_abnormal_sex_gland | 1.17717565 |
| 32 | MP0005666_abnormal_adipose_tissue | 1.14452758 |
| 33 | MP0004233_abnormal_muscle_weight | 1.14010060 |
| 34 | MP0001984_abnormal_olfaction | 1.12626497 |
| 35 | MP0004782_abnormal_surfactant_physiolog | 1.10963085 |
| 36 | MP0009053_abnormal_anal_canal | 1.09328105 |
| 37 | MP0001963_abnormal_hearing_physiology | 1.02087079 |
| 38 | MP0004510_myositis | 0.98603848 |
| 39 | MP0008961_abnormal_basal_metabolism | 0.94495198 |
| 40 | MP0001666_abnormal_nutrient_absorption | 0.91636205 |
| 41 | MP0002127_abnormal_cardiovascular_syste | 0.90586199 |
| 42 | MP0003828_pulmonary_edema | 0.89562531 |
| 43 | MP0002139_abnormal_hepatobiliary_system | 0.89365238 |
| 44 | MP0005253_abnormal_eye_physiology | 0.79743236 |
| 45 | MP0005395_other_phenotype | 0.79348037 |
| 46 | MP0001968_abnormal_touch/_nociception | 0.76672812 |
| 47 | MP0003329_amyloid_beta_deposits | 0.73524559 |
| 48 | MP0005375_adipose_tissue_phenotype | 0.73476079 |
| 49 | MP0002067_abnormal_sensory_capabilities | 0.71952322 |
| 50 | MP0002735_abnormal_chemical_nociception | 0.68591043 |
| 51 | MP0000026_abnormal_inner_ear | 0.67827545 |
| 52 | MP0008995_early_reproductive_senescence | 0.67596759 |
| 53 | MP0000955_abnormal_spinal_cord | 0.66939609 |
| 54 | MP0002928_abnormal_bile_duct | 0.65521442 |
| 55 | MP0000534_abnormal_ureter_morphology | 0.65478593 |
| 56 | MP0002234_abnormal_pharynx_morphology | 0.62143842 |
| 57 | MP0010307_abnormal_tumor_latency | 0.61406762 |
| 58 | MP0001545_abnormal_hematopoietic_system | 0.60935746 |
| 59 | MP0005397_hematopoietic_system_phenotyp | 0.60935746 |
| 60 | MP0003077_abnormal_cell_cycle | 0.58329471 |
| 61 | MP0005551_abnormal_eye_electrophysiolog | 0.57510345 |
| 62 | MP0002229_neurodegeneration | 0.55148823 |
| 63 | MP0003091_abnormal_cell_migration | 0.55121546 |
| 64 | MP0005083_abnormal_biliary_tract | 0.52951453 |
| 65 | MP0005647_abnormal_sex_gland | 0.50107399 |
| 66 | MP0005595_abnormal_vascular_smooth | 0.50027636 |
| 67 | MP0009278_abnormal_bone_marrow | 0.48551492 |
| 68 | MP0010234_abnormal_vibrissa_follicle | 0.43277246 |
| 69 | MP0003115_abnormal_respiratory_system | 0.42050634 |
| 70 | MP0001440_abnormal_grooming_behavior | 0.41813921 |
| 71 | MP0002572_abnormal_emotion/affect_behav | 0.41657068 |
| 72 | MP0008569_lethality_at_weaning | 0.41640719 |
| 73 | MP0000230_abnormal_systemic_arterial | 0.41416069 |
| 74 | MP0005391_vision/eye_phenotype | 0.41279147 |
| 75 | MP0000249_abnormal_blood_vessel | 0.40489723 |
| 76 | MP0001835_abnormal_antigen_presentation | 0.40437367 |
| 77 | MP0003172_abnormal_lysosome_physiology | 0.38928405 |
| 78 | MP0005535_abnormal_body_temperature | 0.38876205 |
| 79 | MP0003137_abnormal_impulse_conducting | 0.38407772 |
| 80 | MP0000049_abnormal_middle_ear | 0.37922483 |
| 81 | MP0000681_abnormal_thyroid_gland | 0.37300437 |
| 82 | MP0004085_abnormal_heartbeat | 0.36936731 |
| 83 | MP0004084_abnormal_cardiac_muscle | 0.36436537 |
| 84 | MP0003635_abnormal_synaptic_transmissio | 0.35724786 |
| 85 | MP0002184_abnormal_innervation | 0.35029010 |
| 86 | MP0002734_abnormal_mechanical_nocicepti | 0.33211026 |
| 87 | MP0008874_decreased_physiological_sensi | 0.33056948 |
| 88 | MP0004484_altered_response_of | 0.32995728 |
| 89 | MP0002138_abnormal_hepatobiliary_system | 0.32940645 |
| 90 | MP0002998_abnormal_bone_remodeling | 0.31207048 |
| 91 | MP0002557_abnormal_social/conspecific_i | 0.30852199 |
| 92 | MP0001501_abnormal_sleep_pattern | 0.30840743 |
| 93 | MP0001905_abnormal_dopamine_level | 0.30670270 |
| 94 | MP0000003_abnormal_adipose_tissue | 0.29901794 |
| 95 | MP0004036_abnormal_muscle_relaxation | 0.29846628 |
| 96 | MP0003699_abnormal_female_reproductive | 0.29416502 |
| 97 | MP0002971_abnormal_brown_adipose | 0.28640415 |
| 98 | MP0002932_abnormal_joint_morphology | 0.28581174 |
| 99 | MP0005636_abnormal_mineral_homeostasis | 0.28476862 |
| 100 | MP0000470_abnormal_stomach_morphology | 0.27994859 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Tubulointerstitial nephritis (HP:0001970) | 6.44797180 |
| 2 | Chronic hepatic failure (HP:0100626) | 6.33612635 |
| 3 | Parkinsonism with favorable response to dopaminergic medication (HP:0002548) | 6.25372740 |
| 4 | Severe visual impairment (HP:0001141) | 5.89898258 |
| 5 | Asymmetric septal hypertrophy (HP:0001670) | 5.74197155 |
| 6 | Absent/shortened dynein arms (HP:0200106) | 5.42775586 |
| 7 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 5.42775586 |
| 8 | Resting tremor (HP:0002322) | 5.22028328 |
| 9 | Cone-rod dystrophy (HP:0000548) | 4.94623071 |
| 10 | Menstrual irregularities (HP:0000858) | 4.89747887 |
| 11 | Nasal polyposis (HP:0100582) | 4.50121781 |
| 12 | Hyperkalemia (HP:0002153) | 4.37177036 |
| 13 | Male infertility (HP:0003251) | 4.29850404 |
| 14 | Bony spicule pigmentary retinopathy (HP:0007737) | 4.18068140 |
| 15 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 3.93128674 |
| 16 | Progressive sensorineural hearing impairment (HP:0000408) | 3.90315374 |
| 17 | Renovascular hypertension (HP:0100817) | 3.88500179 |
| 18 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.87933981 |
| 19 | Truncal obesity (HP:0001956) | 3.83603418 |
| 20 | Abnormal respiratory motile cilium physiology (HP:0012261) | 3.76391856 |
| 21 | Postural instability (HP:0002172) | 3.70225790 |
| 22 | Abnormal ciliary motility (HP:0012262) | 3.66870009 |
| 23 | Attenuation of retinal blood vessels (HP:0007843) | 3.64259774 |
| 24 | Hypoalphalipoproteinemia (HP:0003233) | 3.62454830 |
| 25 | Abnormality of the nasal mucosa (HP:0000433) | 3.59377267 |
| 26 | Growth hormone deficiency (HP:0000824) | 3.55270337 |
| 27 | Abnormal respiratory motile cilium morphology (HP:0005938) | 3.51898658 |
| 28 | Abnormal respiratory epithelium morphology (HP:0012253) | 3.51898658 |
| 29 | Hypoplasia of the thymus (HP:0000778) | 3.51680894 |
| 30 | Infertility (HP:0000789) | 3.48927140 |
| 31 | Abnormality of macular pigmentation (HP:0008002) | 3.40594083 |
| 32 | Amelogenesis imperfecta (HP:0000705) | 3.30758666 |
| 33 | Portal hypertension (HP:0001409) | 3.08834006 |
| 34 | Abnormality of dental color (HP:0011073) | 3.08112875 |
| 35 | Stage 5 chronic kidney disease (HP:0003774) | 3.07698172 |
| 36 | Impulsivity (HP:0100710) | 3.01578212 |
| 37 | Abnormality of the hepatic vasculature (HP:0006707) | 2.98221221 |
| 38 | Insulin-resistant diabetes mellitus (HP:0000831) | 2.98116586 |
| 39 | Severe short stature (HP:0003510) | 2.86168857 |
| 40 | Intellectual disability, moderate (HP:0002342) | 2.84081906 |
| 41 | Progressive cerebellar ataxia (HP:0002073) | 2.83121923 |
| 42 | Tubulointerstitial abnormality (HP:0001969) | 2.70040671 |
| 43 | Enlarged epiphyses (HP:0010580) | 2.69390422 |
| 44 | Facial shape deformation (HP:0011334) | 2.68087192 |
| 45 | Potter facies (HP:0002009) | 2.68087192 |
| 46 | Subcapsular cataract (HP:0000523) | 2.66998558 |
| 47 | Progressive hearing impairment (HP:0001730) | 2.66568628 |
| 48 | Focal segmental glomerulosclerosis (HP:0000097) | 2.62738420 |
| 49 | Abnormal spermatogenesis (HP:0008669) | 2.60094178 |
| 50 | Gingivitis (HP:0000230) | 2.59215802 |
| 51 | Osteomalacia (HP:0002749) | 2.48506186 |
| 52 | Hypolipoproteinemia (HP:0010981) | 2.46474679 |
| 53 | Bell-shaped thorax (HP:0001591) | 2.43069821 |
| 54 | Recurrent pneumonia (HP:0006532) | 2.37227640 |
| 55 | Obsessive-compulsive behavior (HP:0000722) | 2.34276188 |
| 56 | Increased purine levels (HP:0004368) | 2.31461490 |
| 57 | Hyperuricemia (HP:0002149) | 2.31461490 |
| 58 | Sandal gap (HP:0001852) | 2.22199157 |
| 59 | Abnormality of the costochondral junction (HP:0000919) | 2.21096339 |
| 60 | Abnormal rod and cone electroretinograms (HP:0008323) | 2.19667228 |
| 61 | Abnormality of potassium homeostasis (HP:0011042) | 2.18105638 |
| 62 | Abnormality of the fingertips (HP:0001211) | 2.14432795 |
| 63 | Ventricular tachycardia (HP:0004756) | 2.02988824 |
| 64 | Rhinitis (HP:0012384) | 2.02093907 |
| 65 | Abnormal urine output (HP:0012590) | 1.99880822 |
| 66 | Hypoplastic ischia (HP:0003175) | 1.98091940 |
| 67 | Azoospermia (HP:0000027) | 1.96264542 |
| 68 | Nephronophthisis (HP:0000090) | 1.95902438 |
| 69 | Abnormal drinking behavior (HP:0030082) | 1.93800997 |
| 70 | Polydipsia (HP:0001959) | 1.93800997 |
| 71 | Glomerulosclerosis (HP:0000096) | 1.92015827 |
| 72 | Chronic bronchitis (HP:0004469) | 1.90774370 |
| 73 | Neoplasm of the heart (HP:0100544) | 1.86383046 |
| 74 | Bilateral sensorineural hearing impairment (HP:0008619) | 1.85371789 |
| 75 | Abnormality of the ischium (HP:0003174) | 1.81897842 |
| 76 | Abnormality of the aortic arch (HP:0012303) | 1.80928312 |
| 77 | Abnormality of the renal medulla (HP:0100957) | 1.80144267 |
| 78 | Insulin resistance (HP:0000855) | 1.78243611 |
| 79 | Hypoalbuminemia (HP:0003073) | 1.75470583 |
| 80 | Abnormal albumin level (HP:0012116) | 1.75470583 |
| 81 | Abnormality of renal excretion (HP:0011036) | 1.73823930 |
| 82 | Deep palmar crease (HP:0006191) | 1.73648966 |
| 83 | Bronchiectasis (HP:0002110) | 1.73361067 |
| 84 | Horizontal nystagmus (HP:0000666) | 1.73307270 |
| 85 | Slow saccadic eye movements (HP:0000514) | 1.69791570 |
| 86 | Bradycardia (HP:0001662) | 1.69777806 |
| 87 | Abnormality of chloride homeostasis (HP:0011422) | 1.69121914 |
| 88 | Myokymia (HP:0002411) | 1.66572627 |
| 89 | Acanthosis nigricans (HP:0000956) | 1.64814445 |
| 90 | Gastrointestinal infarctions (HP:0005244) | 1.64381947 |
| 91 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 1.63636148 |
| 92 | Termporal pattern (HP:0011008) | 1.63132193 |
| 93 | Insidious onset (HP:0003587) | 1.63132193 |
| 94 | Flattened epiphyses (HP:0003071) | 1.62747619 |
| 95 | Esophageal varix (HP:0002040) | 1.62102919 |
| 96 | Widely patent fontanelles and sutures (HP:0004492) | 1.60256743 |
| 97 | Convex nasal ridge (HP:0000444) | 1.58216739 |
| 98 | Underdeveloped nasal alae (HP:0000430) | 1.58098806 |
| 99 | Polyuria (HP:0000103) | 1.56190219 |
| 100 | Nephritis (HP:0000123) | 1.55578462 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PLK4 | 8.79655979 |
| 2 | BRD4 | 5.21573311 |
| 3 | INSRR | 4.10005532 |
| 4 | PLK2 | 3.55577628 |
| 5 | PNCK | 3.27725979 |
| 6 | CAMK1G | 2.99203900 |
| 7 | TESK1 | 2.95809222 |
| 8 | PIK3CG | 2.85766370 |
| 9 | MAP3K11 | 2.23709521 |
| 10 | BLK | 2.23601778 |
| 11 | DDR2 | 2.19577437 |
| 12 | MAP4K2 | 2.11740580 |
| 13 | STK38 | 1.98161695 |
| 14 | KSR2 | 1.87571540 |
| 15 | PRKD3 | 1.75854809 |
| 16 | CDK12 | 1.70277839 |
| 17 | PDK1 | 1.63660093 |
| 18 | PDPK1 | 1.63415394 |
| 19 | CAMK1D | 1.59384489 |
| 20 | TYRO3 | 1.56221962 |
| 21 | STK38L | 1.55281219 |
| 22 | WNK1 | 1.49567326 |
| 23 | MAP3K1 | 1.43234498 |
| 24 | MST1R | 1.32239740 |
| 25 | PTK2B | 1.28157510 |
| 26 | NEK6 | 1.27616454 |
| 27 | MAP3K9 | 1.23329380 |
| 28 | BRAF | 1.10740169 |
| 29 | MAPK15 | 1.03477799 |
| 30 | AKT3 | 1.01424294 |
| 31 | JAK3 | 0.97968158 |
| 32 | DYRK1B | 0.96368576 |
| 33 | MAP3K2 | 0.95448941 |
| 34 | MAP4K1 | 0.90340620 |
| 35 | RIPK4 | 0.89829097 |
| 36 | CDK19 | 0.88155037 |
| 37 | MAP3K13 | 0.83729300 |
| 38 | ARAF | 0.82128039 |
| 39 | MARK2 | 0.79733049 |
| 40 | TAOK1 | 0.68174439 |
| 41 | PRKG2 | 0.67322671 |
| 42 | PRKAA2 | 0.66914893 |
| 43 | OXSR1 | 0.64899566 |
| 44 | SGK223 | 0.64317593 |
| 45 | SGK494 | 0.64317593 |
| 46 | SIK2 | 0.63262557 |
| 47 | LATS1 | 0.61397669 |
| 48 | CDK7 | 0.60234878 |
| 49 | GRK6 | 0.54321433 |
| 50 | CAMK1 | 0.53950133 |
| 51 | SGK2 | 0.50777886 |
| 52 | NTRK3 | 0.44124300 |
| 53 | MARK1 | 0.43603199 |
| 54 | MAP2K2 | 0.42184486 |
| 55 | PRKG1 | 0.41263763 |
| 56 | JAK2 | 0.40901690 |
| 57 | CAMK4 | 0.39852638 |
| 58 | TIE1 | 0.38832060 |
| 59 | SGK1 | 0.38454285 |
| 60 | RPS6KA2 | 0.37321221 |
| 61 | SGK3 | 0.36054472 |
| 62 | MAP2K4 | 0.36014176 |
| 63 | RPS6KA1 | 0.35925757 |
| 64 | MAP3K7 | 0.35298237 |
| 65 | MAPK1 | 0.35067654 |
| 66 | ACVR1B | 0.34711979 |
| 67 | MAP3K8 | 0.34145130 |
| 68 | STK11 | 0.32526378 |
| 69 | PRKCZ | 0.32251057 |
| 70 | CDK2 | 0.31541638 |
| 71 | GSK3B | 0.30102874 |
| 72 | CDK1 | 0.29831044 |
| 73 | LATS2 | 0.29101476 |
| 74 | CSK | 0.27388529 |
| 75 | CDK4 | 0.26191280 |
| 76 | MAPK8 | 0.24835582 |
| 77 | MTOR | 0.24795352 |
| 78 | DYRK3 | 0.24767826 |
| 79 | CHEK1 | 0.24687944 |
| 80 | RAF1 | 0.23779396 |
| 81 | BRSK2 | 0.21046294 |
| 82 | CSF1R | 0.20115429 |
| 83 | MAPK10 | 0.19974303 |
| 84 | BRSK1 | 0.19818651 |
| 85 | ICK | 0.19553302 |
| 86 | KSR1 | 0.19479882 |
| 87 | SYK | 0.18845472 |
| 88 | MOS | 0.17776297 |
| 89 | CDK3 | 0.14886599 |
| 90 | AKT1 | 0.14755822 |
| 91 | RPS6KC1 | 0.13991637 |
| 92 | RPS6KL1 | 0.13991637 |
| 93 | ERBB2 | 0.13064283 |
| 94 | MAPK9 | 0.11030828 |
| 95 | HCK | 0.10297886 |
| 96 | MET | 0.08706465 |
| 97 | IRAK4 | 0.08120176 |
| 98 | MAPK14 | 0.07897345 |
| 99 | RPS6KA6 | 0.07644299 |
| 100 | ZAP70 | 0.07177252 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 6.74219474 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 3.00735244 |
| 3 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.84938443 |
| 4 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.44181035 |
| 5 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 2.08828858 |
| 6 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.59758458 |
| 7 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.45155457 |
| 8 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.44665517 |
| 9 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 1.41039784 |
| 10 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.37882346 |
| 11 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 1.36799683 |
| 12 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.36788771 |
| 13 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.28760016 |
| 14 | Taste transduction_Homo sapiens_hsa04742 | 1.26404135 |
| 15 | RNA transport_Homo sapiens_hsa03013 | 1.21254535 |
| 16 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.20790103 |
| 17 | Fatty acid degradation_Homo sapiens_hsa00071 | 1.18803870 |
| 18 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.12938323 |
| 19 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.11488961 |
| 20 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.11260995 |
| 21 | ABC transporters_Homo sapiens_hsa02010 | 1.10497536 |
| 22 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 1.09674373 |
| 23 | VEGF signaling pathway_Homo sapiens_hsa04370 | 1.08506167 |
| 24 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.05886540 |
| 25 | Influenza A_Homo sapiens_hsa05164 | 1.04494812 |
| 26 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 1.01372697 |
| 27 | Bile secretion_Homo sapiens_hsa04976 | 1.00662530 |
| 28 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.00612279 |
| 29 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.99678578 |
| 30 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.97268001 |
| 31 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.96504127 |
| 32 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.96304626 |
| 33 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.95023669 |
| 34 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.94224956 |
| 35 | Long-term potentiation_Homo sapiens_hsa04720 | 0.94031221 |
| 36 | Morphine addiction_Homo sapiens_hsa05032 | 0.93936973 |
| 37 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.89732482 |
| 38 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.87119185 |
| 39 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.86318150 |
| 40 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.86050575 |
| 41 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.85984685 |
| 42 | Salivary secretion_Homo sapiens_hsa04970 | 0.83026755 |
| 43 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.80389829 |
| 44 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.79427172 |
| 45 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.78603099 |
| 46 | Glioma_Homo sapiens_hsa05214 | 0.77788910 |
| 47 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.75694190 |
| 48 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.75027769 |
| 49 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.72091486 |
| 50 | Endocytosis_Homo sapiens_hsa04144 | 0.71499659 |
| 51 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.71455264 |
| 52 | Circadian entrainment_Homo sapiens_hsa04713 | 0.70089627 |
| 53 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.69025265 |
| 54 | Prostate cancer_Homo sapiens_hsa05215 | 0.68844658 |
| 55 | Leishmaniasis_Homo sapiens_hsa05140 | 0.67948056 |
| 56 | Nicotine addiction_Homo sapiens_hsa05033 | 0.67662890 |
| 57 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.67351410 |
| 58 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.66304700 |
| 59 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.65867389 |
| 60 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.64621753 |
| 61 | Viral myocarditis_Homo sapiens_hsa05416 | 0.63233005 |
| 62 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.61704820 |
| 63 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.61674074 |
| 64 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.60874682 |
| 65 | Tuberculosis_Homo sapiens_hsa05152 | 0.60839530 |
| 66 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.60134008 |
| 67 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.57396945 |
| 68 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.57284155 |
| 69 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.56697841 |
| 70 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.56348801 |
| 71 | Endometrial cancer_Homo sapiens_hsa05213 | 0.55957358 |
| 72 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.55680397 |
| 73 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.54911443 |
| 74 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.54797468 |
| 75 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.54434227 |
| 76 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.53862803 |
| 77 | Hepatitis B_Homo sapiens_hsa05161 | 0.53083603 |
| 78 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.52810226 |
| 79 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.50383362 |
| 80 | Platelet activation_Homo sapiens_hsa04611 | 0.49882328 |
| 81 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.49094206 |
| 82 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.48666092 |
| 83 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.48390332 |
| 84 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.46737314 |
| 85 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.46707677 |
| 86 | Renin secretion_Homo sapiens_hsa04924 | 0.46629902 |
| 87 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.46232092 |
| 88 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.45166323 |
| 89 | Gap junction_Homo sapiens_hsa04540 | 0.42696803 |
| 90 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.42693792 |
| 91 | GABAergic synapse_Homo sapiens_hsa04727 | 0.42367184 |
| 92 | Allograft rejection_Homo sapiens_hsa05330 | 0.42116551 |
| 93 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.41833950 |
| 94 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.41767068 |
| 95 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.41120728 |
| 96 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.38654190 |
| 97 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.38631756 |
| 98 | Lysine degradation_Homo sapiens_hsa00310 | 0.38250927 |
| 99 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.38167848 |
| 100 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.38083252 |

