C11ORF45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)7.64950210
2glycosphingolipid catabolic process (GO:0046479)6.92931333
3oligosaccharide catabolic process (GO:0009313)6.81342919
4glycolipid catabolic process (GO:0019377)6.23088209
5amino sugar catabolic process (GO:0046348)5.72633445
6ceramide catabolic process (GO:0046514)5.54188300
7regulation of syncytium formation by plasma membrane fusion (GO:0060142)5.41921007
8cellular response to thyroid hormone stimulus (GO:0097067)5.14016731
9regulation of cholesterol storage (GO:0010885)4.92839327
10positive regulation of bone resorption (GO:0045780)4.59378052
11positive regulation of bone remodeling (GO:0046852)4.59378052
12osteoclast differentiation (GO:0030316)4.40478308
13negative regulation of interleukin-12 production (GO:0032695)4.37360972
14response to peptidoglycan (GO:0032494)4.36156490
15negative regulation of nitric oxide biosynthetic process (GO:0045019)4.27750289
16regulation of monocyte differentiation (GO:0045655)4.23995091
17response to thyroid hormone (GO:0097066)4.19663629
18membrane lipid catabolic process (GO:0046466)4.18979769
19neutrophil activation involved in immune response (GO:0002283)4.18785768
20positive regulation of monocyte chemotaxis (GO:0090026)4.13698924
21barbed-end actin filament capping (GO:0051016)4.13388569
22sphingolipid catabolic process (GO:0030149)4.12135048
23pinocytosis (GO:0006907)4.06270011
24regulation of mononuclear cell migration (GO:0071675)3.88453999
25regulation of vitamin D biosynthetic process (GO:0060556)3.88240463
26myeloid dendritic cell differentiation (GO:0043011)3.82415803
27positive regulation of leukocyte degranulation (GO:0043302)3.78526665
28protein localization to endosome (GO:0036010)3.75001569
29glucosamine-containing compound catabolic process (GO:1901072)3.73607895
30apoptotic cell clearance (GO:0043277)3.72258781
31positive regulation of tissue remodeling (GO:0034105)3.55947366
32N-acetylneuraminate metabolic process (GO:0006054)3.50610888
33cellular extravasation (GO:0045123)3.47288673
34positive regulation of mast cell activation (GO:0033005)3.41183609
35myeloid dendritic cell activation (GO:0001773)3.40795657
36macrophage differentiation (GO:0030225)3.33748595
37regulation of superoxide anion generation (GO:0032928)3.31167048
38positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.29117761
39positive regulation of mast cell degranulation (GO:0043306)3.27770156
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.27770156
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.27378420
42decidualization (GO:0046697)3.25647390
43fat-soluble vitamin biosynthetic process (GO:0042362)3.24502226
44regulation of mast cell degranulation (GO:0043304)3.20835466
45regulation of monocyte chemotaxis (GO:0090025)3.19019149
46regulation of leukocyte degranulation (GO:0043300)3.16510152
47ganglioside metabolic process (GO:0001573)3.13410746
48keratan sulfate catabolic process (GO:0042340)3.12657659
49dendritic cell differentiation (GO:0097028)3.12455065
50macrophage activation involved in immune response (GO:0002281)3.11425911
51positive regulation of cholesterol efflux (GO:0010875)3.10071330
52negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.09464191
53positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.06819053
54phagosome maturation (GO:0090382)3.05718280
55eosinophil chemotaxis (GO:0048245)3.05699849
56regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.03982250
57regulation of vitamin metabolic process (GO:0030656)3.02399917
58monocyte chemotaxis (GO:0002548)2.96451078
59immunoglobulin mediated immune response (GO:0016064)2.94328997
60regulation of mast cell activation involved in immune response (GO:0033006)2.91624915
61peptide catabolic process (GO:0043171)2.87449309
62regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.86975724
63negative regulation of lipid storage (GO:0010888)2.86594566
64cellular response to arsenic-containing substance (GO:0071243)2.85728003
65T-helper 1 type immune response (GO:0042088)2.82904340
66regulation of myeloid leukocyte mediated immunity (GO:0002886)2.82090498
67positive regulation of osteoclast differentiation (GO:0045672)2.81982926
68granulocyte activation (GO:0036230)2.80599419
69hyaluronan catabolic process (GO:0030214)2.79901007
70detection of molecule of bacterial origin (GO:0032490)2.79530957
71positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.79118214
72regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77418605
73positive regulation of chemokine biosynthetic process (GO:0045080)2.76478106
74regulation of mast cell activation (GO:0033003)2.75498865
75eosinophil migration (GO:0072677)2.74654150
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73928351
77intracellular pH reduction (GO:0051452)2.72556623
78positive regulation of antigen processing and presentation (GO:0002579)2.70535342
79respiratory burst (GO:0045730)2.69860393
80regulation of macrophage chemotaxis (GO:0010758)2.68911083
81NIK/NF-kappaB signaling (GO:0038061)2.68884292
82positive regulation of gamma-delta T cell activation (GO:0046645)2.68659094
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68584736
84pH reduction (GO:0045851)2.68025962
85vitamin D metabolic process (GO:0042359)2.67015520
86regulation of podosome assembly (GO:0071801)2.65873236
87positive regulation of cellular amide metabolic process (GO:0034250)2.63621991
88transferrin transport (GO:0033572)2.58901999
89regulation of bone resorption (GO:0045124)2.58740673
90positive regulation of sterol transport (GO:0032373)2.56188592
91positive regulation of cholesterol transport (GO:0032376)2.56188592
92regulation of macrophage derived foam cell differentiation (GO:0010743)2.54617222
93negative regulation of monooxygenase activity (GO:0032769)2.53119098
94lysosome organization (GO:0007040)2.51763186
95lytic vacuole organization (GO:0080171)2.51763186
96membrane raft organization (GO:0031579)2.50999178
97mannose metabolic process (GO:0006013)2.50605458
98myeloid cell activation involved in immune response (GO:0002275)2.50410662
99modulation by symbiont of host immune response (GO:0052553)2.48615890
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.48615890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.47464253
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.39906075
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.36625486
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.15660533
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.69695951
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.47669661
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.39009746
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32547187
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03010239
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01966390
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.66723578
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.57401152
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.42264355
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39890661
15BRD4_27068464_Chip-Seq_AML-cells_Mouse2.33894699
16VDR_24763502_ChIP-Seq_THP-1_Human2.21502201
17VDR_24787735_ChIP-Seq_THP-1_Human2.21078341
18VDR_21846776_ChIP-Seq_THP-1_Human2.18005216
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06769929
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04730748
21SPI1_23547873_ChIP-Seq_NB4_Human2.04003197
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03959090
23SPI1_23127762_ChIP-Seq_K562_Human1.96969449
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.94519045
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89676560
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86358691
27GATA1_22025678_ChIP-Seq_K562_Human1.83237288
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80441997
29TFEB_21752829_ChIP-Seq_HELA_Human1.79495143
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.79467512
31SCL_19346495_ChIP-Seq_HPC-7_Human1.74714274
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74402487
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73497379
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.69575366
35CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67618043
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.64775367
37TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64017335
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60786844
39LXR_22292898_ChIP-Seq_THP-1_Human1.59987614
40STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59699848
41SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.55577104
42CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51310581
43PU_27001747_Chip-Seq_BMDM_Mouse1.50732316
44MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46907189
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44751602
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.40733996
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38909634
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37934903
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34368290
50NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34241857
51* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34075255
52CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27163870
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26171681
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26014211
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25517107
56CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24564734
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22966863
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19948550
59TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19698199
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18139817
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.17870081
62CLOCK_20551151_ChIP-Seq_293T_Human1.17760641
63MAF_26560356_Chip-Seq_TH1_Human1.17299289
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16418264
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.14459336
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14438366
67SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12473956
68SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12473956
69KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11919172
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11426557
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11424043
72SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07917587
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07316867
74PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06629037
75TCF7_22412390_ChIP-Seq_EML_Mouse1.06403357
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04176684
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03993290
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03615449
79RACK7_27058665_Chip-Seq_MCF-7_Human1.02631743
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02531844
81STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02304018
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99665899
83GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98681080
84GATA1_19941826_ChIP-Seq_K562_Human0.98036172
85ZNF263_19887448_ChIP-Seq_K562_Human0.96137646
86MYC_22102868_ChIP-Seq_BL_Human0.95994662
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94410248
88KDM2B_26808549_Chip-Seq_DND41_Human0.94330863
89* UBF1/2_26484160_Chip-Seq_HMECs_Human0.92477640
90JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91026515
91RXR_22158963_ChIP-Seq_LIVER_Mouse0.90549441
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89405571
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88218043
94KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87907439
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87793158
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86756533
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.86205711
98NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86182485
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85931225
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.85028838

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology5.00946422
2MP0003191_abnormal_cellular_cholesterol4.14886473
3MP0009840_abnormal_foam_cell3.95357294
4MP0003303_peritoneal_inflammation3.37294705
5MP0000604_amyloidosis3.33731110
6MP0006082_CNS_inflammation3.23646690
7MP0003172_abnormal_lysosome_physiology3.09512479
8MP0002139_abnormal_hepatobiliary_system2.75916925
9MP0002148_abnormal_hypersensitivity_rea2.65632663
10MP0002419_abnormal_innate_immunity2.53906266
11MP0000343_altered_response_to2.50991255
12MP0003436_decreased_susceptibility_to2.50427018
13MP0005451_abnormal_body_composition2.40133086
14MP0003724_increased_susceptibility_to2.37289800
15MP0002877_abnormal_melanocyte_morpholog2.34845696
16MP0003329_amyloid_beta_deposits2.24334499
17MP0001835_abnormal_antigen_presentation2.10925480
18MP0009785_altered_susceptibility_to2.10152407
19MP0001853_heart_inflammation2.05997383
20MP0003300_gastrointestinal_ulcer2.04480846
21MP0002998_abnormal_bone_remodeling1.99740006
22MP0003075_altered_response_to1.96421353
23MP0005671_abnormal_response_to1.93029999
24MP0004510_myositis1.91549792
25MP0005000_abnormal_immune_tolerance1.91310467
26MP0005025_abnormal_response_to1.91147270
27MP0009278_abnormal_bone_marrow1.86748412
28MP0003806_abnormal_nucleotide_metabolis1.84406746
29MP0005387_immune_system_phenotype1.81788935
30MP0001790_abnormal_immune_system1.81788935
31MP0002452_abnormal_antigen_presenting1.77920543
32MP0001533_abnormal_skeleton_physiology1.77465682
33MP0005464_abnormal_platelet_physiology1.65137468
34MP0005397_hematopoietic_system_phenotyp1.63399530
35MP0001545_abnormal_hematopoietic_system1.63399530
36MP0009764_decreased_sensitivity_to1.56567306
37MP0003690_abnormal_glial_cell1.55380092
38MP0003453_abnormal_keratinocyte_physiol1.54731717
39MP0002723_abnormal_immune_serum1.52587552
40MP0009333_abnormal_splenocyte_physiolog1.51368007
41MP0004947_skin_inflammation1.50565898
42MP0005365_abnormal_bile_salt1.45181004
43MP0001845_abnormal_inflammatory_respons1.42095324
44MP0003448_altered_tumor_morphology1.39844068
45MP0000858_altered_metastatic_potential1.37948122
46MP0000685_abnormal_immune_system1.37772279
47MP0005310_abnormal_salivary_gland1.36856313
48MP0002405_respiratory_system_inflammati1.36314050
49MP0002420_abnormal_adaptive_immunity1.35921924
50MP0006054_spinal_hemorrhage1.35905679
51MP0001819_abnormal_immune_cell1.35133135
52MP0005257_abnormal_intraocular_pressure1.34705948
53MP0008469_abnormal_protein_level1.30892962
54MP0003828_pulmonary_edema1.28755996
55MP0001800_abnormal_humoral_immune1.21332021
56MP0003656_abnormal_erythrocyte_physiolo1.20704506
57MP0003950_abnormal_plasma_membrane1.20615099
58MP0003705_abnormal_hypodermis_morpholog1.17371974
59MP0005165_increased_susceptibility_to1.13847192
60MP0003091_abnormal_cell_migration1.13173242
61MP0005166_decreased_susceptibility_to1.12716508
62MP0008260_abnormal_autophagy1.11231574
63MP0005164_abnormal_response_to1.07951959
64MP0000920_abnormal_myelination1.05292594
65MP0001849_ear_inflammation1.04928557
66MP0002090_abnormal_vision1.04504016
67MP0004883_abnormal_blood_vessel1.02793373
68MP0005647_abnormal_sex_gland0.96946513
69MP0003566_abnormal_cell_adhesion0.95891641
70MP0004808_abnormal_hematopoietic_stem0.92853331
71MP0005167_abnormal_blood-brain_barrier0.91889292
72MP0003279_aneurysm0.91135576
73MP0002254_reproductive_system_inflammat0.89983482
74MP0000371_diluted_coat_color0.89908328
75MP0005023_abnormal_wound_healing0.89711718
76MP0010155_abnormal_intestine_physiology0.88951184
77MP0003795_abnormal_bone_structure0.88593921
78MP0000716_abnormal_immune_system0.87162407
79MP0010234_abnormal_vibrissa_follicle0.86354116
80MP0005390_skeleton_phenotype0.85501699
81MP0002332_abnormal_exercise_endurance0.83919211
82MP0003634_abnormal_glial_cell0.83200763
83MP0009763_increased_sensitivity_to0.83175713
84MP0001727_abnormal_embryo_implantation0.81440104
85MP0003195_calcinosis0.81379815
86MP0010307_abnormal_tumor_latency0.79322874
87MP0008004_abnormal_stomach_pH0.77803094
88MP0001542_abnormal_bone_strength0.76638429
89MP0003183_abnormal_peptide_metabolism0.72791985
90MP0004185_abnormal_adipocyte_glucose0.71804768
91MP0002896_abnormal_bone_mineralization0.71081316
92MP0001216_abnormal_epidermal_layer0.70149633
93MP0001851_eye_inflammation0.70070972
94MP0002429_abnormal_blood_cell0.70013719
95MP0000249_abnormal_blood_vessel0.69579098
96MP0000465_gastrointestinal_hemorrhage0.67864582
97MP0003632_abnormal_nervous_system0.66514881
98MP0005595_abnormal_vascular_smooth0.65190347
99MP0008874_decreased_physiological_sensi0.64367030
100MP0000689_abnormal_spleen_morphology0.63661684

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)9.78494580
2Abnormality of glycosphingolipid metabolism (HP:0004343)9.78494580
3Abnormality of glycolipid metabolism (HP:0010969)9.78494580
4Vacuolated lymphocytes (HP:0001922)6.08455886
5Increased cerebral lipofuscin (HP:0011813)5.80221804
6Dysostosis multiplex (HP:0000943)4.84718632
7Abnormality of macrophages (HP:0004311)4.64949906
8Disinhibition (HP:0000734)4.63158781
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.61732175
10Loss of speech (HP:0002371)4.55642534
11Systemic lupus erythematosus (HP:0002725)3.92812653
12Neurofibrillary tangles (HP:0002185)3.90375795
13Axonal loss (HP:0003447)3.84933053
14Recurrent abscess formation (HP:0002722)3.83537937
15Recurrent bacterial skin infections (HP:0005406)3.81534946
16Myocardial infarction (HP:0001658)3.79274900
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.75572062
18Abnormality of polysaccharide metabolism (HP:0011012)3.75572062
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.75572062
20Mucopolysacchariduria (HP:0008155)3.63534403
21Urinary glycosaminoglycan excretion (HP:0003541)3.63534403
22Eczematoid dermatitis (HP:0000976)3.53981252
23Mutism (HP:0002300)3.53259680
24Autoimmune thrombocytopenia (HP:0001973)3.49635966
25Apathy (HP:0000741)3.29102333
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.27233852
27Upper motor neuron abnormality (HP:0002127)3.24468402
28Diminished motivation (HP:0000745)3.24420424
29Recurrent gram-negative bacterial infections (HP:0005420)3.10778155
30Nuclear cataract (HP:0100018)3.09430220
31Hepatosplenomegaly (HP:0001433)2.93060665
32Cerebral inclusion bodies (HP:0100314)2.93027929
33Mediastinal lymphadenopathy (HP:0100721)2.81482850
34Agnosia (HP:0010524)2.78699194
35Neuronal loss in central nervous system (HP:0002529)2.70543364
36Asymmetric septal hypertrophy (HP:0001670)2.59072600
37Metaphyseal irregularity (HP:0003025)2.58280634
38Purpura (HP:0000979)2.49879975
39Inappropriate behavior (HP:0000719)2.48826002
40Progressive neurologic deterioration (HP:0002344)2.44446929
41Thick nail (HP:0001805)2.39137749
42Abnormality of the vasculature of the conjunctiva (HP:0008054)2.34828547
43Multiple enchondromatosis (HP:0005701)2.32480748
44Personality changes (HP:0000751)2.30756419
45Vertebral compression fractures (HP:0002953)2.28404750
46Prolonged neonatal jaundice (HP:0006579)2.27883860
47Bone pain (HP:0002653)2.26768288
48Increased serum ferritin (HP:0003281)2.25426961
49Abnormality of the periventricular white matter (HP:0002518)2.23942396
50Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23339579
51Cardiomegaly (HP:0001640)2.20743916
52Obstructive lung disease (HP:0006536)2.18537233
53Chronic obstructive pulmonary disease (HP:0006510)2.18537233
54Pathologic fracture (HP:0002756)2.18399343
55Dementia (HP:0000726)2.18377904
56Interstitial pulmonary disease (HP:0006530)2.18236900
57Thoracic kyphosis (HP:0002942)2.17900859
58Protuberant abdomen (HP:0001538)2.16501029
59Xanthomatosis (HP:0000991)2.12812333
60Poor head control (HP:0002421)2.10111940
61Skin nodule (HP:0200036)2.07834741
62Petechiae (HP:0000967)2.06895946
63Retinal atrophy (HP:0001105)2.04791604
64J-shaped sella turcica (HP:0002680)2.03680154
65Basal ganglia calcification (HP:0002135)2.03057692
66Glomerulonephritis (HP:0000099)2.02510450
67Neoplasm of head and neck (HP:0012288)2.00717931
68Esophageal neoplasm (HP:0100751)2.00717931
69Recurrent skin infections (HP:0001581)1.99925995
70Gingivitis (HP:0000230)1.97206355
71Global brain atrophy (HP:0002283)1.96112278
72Peripheral demyelination (HP:0011096)1.94190720
73Stomatitis (HP:0010280)1.91109959
74Amyloidosis (HP:0011034)1.89923919
75Supranuclear gaze palsy (HP:0000605)1.89911307
76Symptomatic seizures (HP:0011145)1.89390084
77Prostate neoplasm (HP:0100787)1.86757059
78Nausea (HP:0002018)1.86051999
79Multiple lipomas (HP:0001012)1.79768377
80Abnormality of the lumbar spine (HP:0100712)1.78193513
81Increased CSF protein (HP:0002922)1.75554780
82Thin bony cortex (HP:0002753)1.74605366
83Abnormality of iron homeostasis (HP:0011031)1.72667491
84Paralysis (HP:0003470)1.70996139
85Osteolytic defects of the hand bones (HP:0009699)1.70783080
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.70783080
87Spondylolisthesis (HP:0003302)1.69834859
88Abnormal trabecular bone morphology (HP:0100671)1.61308682
89Abnormality of the thoracic spine (HP:0100711)1.60568102
90Hematochezia (HP:0002573)1.59154474
91Complement deficiency (HP:0004431)1.58280971
92Abnormality of the basal ganglia (HP:0002134)1.57724777
93Ovoid vertebral bodies (HP:0003300)1.57245884
94Bone cyst (HP:0012062)1.56972130
95Tetraparesis (HP:0002273)1.56899053
96Progressive visual loss (HP:0000529)1.56618846
97Conjunctival telangiectasia (HP:0000524)1.55223531
98Recurrent viral infections (HP:0004429)1.55103014
99Recurrent fungal infections (HP:0002841)1.53538951
100Premature loss of primary teeth (HP:0006323)1.53536199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.72796749
2NME24.43946201
3GRK73.15732581
4TGFBR22.69775276
5INSRR2.68139677
6BLK2.53676882
7TAOK22.38585963
8MAP3K142.38307940
9MAP3K32.17453907
10PIM22.01201387
11NEK91.98938978
12TBK11.97457119
13ABL21.96560313
14MOS1.92778168
15DDR21.89193589
16MAP2K31.86656779
17PRPF4B1.86368431
18TYK21.78824004
19MAP3K111.78056374
20CSK1.72772607
21ARAF1.65797563
22LIMK11.63019928
23TESK21.62542949
24PAK41.58520907
25FGR1.57400939
26RIPK41.56071897
27CAMKK21.51942823
28CAMK1D1.48536916
29MATK1.47993742
30PDK21.43430530
31TTN1.41493873
32ERN11.41424833
33ZAP701.39728549
34ACVR1B1.38967376
35TESK11.28382330
36MAP3K131.28317971
37TAOK11.27377951
38IKBKB1.20179568
39RIPK11.18978103
40IRAK41.13889547
41STK101.12111199
42CDC42BPA1.11586140
43PBK1.01118407
44CSF1R0.99801867
45CDK60.94424414
46MAP3K50.93091414
47MAP3K10.89863543
48TRIB30.89796843
49IKBKE0.86196772
50SCYL20.85772319
51ERBB40.84203112
52PDGFRA0.83452778
53PIK3CG0.83135042
54JAK30.82797323
55RPS6KA20.81808941
56MST1R0.81740901
57BMPR20.81146680
58CAMK1G0.75608424
59MAP3K80.72410305
60PDPK10.70125224
61JAK10.69095101
62IRAK20.69013724
63LYN0.66798913
64RPS6KL10.66777328
65RPS6KC10.66777328
66ADRBK20.63966390
67MAP4K10.62846487
68MARK30.61727109
69KIT0.60273141
70BMX0.59776345
71FES0.59720861
72LATS20.59353855
73EPHB20.58906476
74SYK0.57594275
75HCK0.54407948
76ICK0.52607256
77MAPK120.51950712
78TRPM70.51132311
79JAK20.51089650
80RPS6KA60.48261844
81KSR20.46912357
82PDK10.45255500
83LCK0.44486700
84ABL10.44315761
85PRKG20.42520299
86MAP2K60.41011751
87PDGFRB0.38577705
88TAOK30.35830256
89CHUK0.35712869
90GSK3A0.31511616
91MAPK40.31385528
92MAP3K20.31218156
93MAPKAPK20.31037876
94MAP3K60.30878046
95MAPK70.27884895
96INSR0.27623906
97SGK30.26432056
98SIK10.26083319
99CAMK2G0.25771250
100DAPK30.25396364

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.63793817
2Lysosome_Homo sapiens_hsa041424.51686333
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.62576546
4Glycosaminoglycan degradation_Homo sapiens_hsa005313.37411135
5Rheumatoid arthritis_Homo sapiens_hsa053232.78341864
6Osteoclast differentiation_Homo sapiens_hsa043802.50221073
7Staphylococcus aureus infection_Homo sapiens_hsa051502.43159128
8Phagosome_Homo sapiens_hsa041452.16197875
9Leishmaniasis_Homo sapiens_hsa051402.14986805
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11524961
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09153013
12Tuberculosis_Homo sapiens_hsa051522.09103576
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.95899373
14Collecting duct acid secretion_Homo sapiens_hsa049661.89660479
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.87206308
16Malaria_Homo sapiens_hsa051441.67334709
17Asthma_Homo sapiens_hsa053101.62884432
18Pertussis_Homo sapiens_hsa051331.59738690
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.54605017
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.51605195
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.49973538
22Vibrio cholerae infection_Homo sapiens_hsa051101.48798647
23Allograft rejection_Homo sapiens_hsa053301.46792291
24Salmonella infection_Homo sapiens_hsa051321.44831796
25Antigen processing and presentation_Homo sapiens_hsa046121.43876508
26TNF signaling pathway_Homo sapiens_hsa046681.43175782
27Legionellosis_Homo sapiens_hsa051341.42880929
28Toxoplasmosis_Homo sapiens_hsa051451.34303635
29Galactose metabolism_Homo sapiens_hsa000521.22650397
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20652176
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19493608
32Graft-versus-host disease_Homo sapiens_hsa053321.18040482
33Autoimmune thyroid disease_Homo sapiens_hsa053201.17613874
34Hematopoietic cell lineage_Homo sapiens_hsa046401.16660423
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.14571278
36RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13071785
37Sphingolipid metabolism_Homo sapiens_hsa006001.10425513
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.07477420
39Bladder cancer_Homo sapiens_hsa052191.06618723
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.06327316
41Influenza A_Homo sapiens_hsa051641.06114270
42B cell receptor signaling pathway_Homo sapiens_hsa046621.05093798
43Prion diseases_Homo sapiens_hsa050201.04866925
44Viral myocarditis_Homo sapiens_hsa054161.03793488
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03675172
46Apoptosis_Homo sapiens_hsa042100.99259705
47Pentose phosphate pathway_Homo sapiens_hsa000300.99233049
48Shigellosis_Homo sapiens_hsa051310.98951508
49Fructose and mannose metabolism_Homo sapiens_hsa000510.90656549
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86035765
51Sulfur metabolism_Homo sapiens_hsa009200.84806313
52PPAR signaling pathway_Homo sapiens_hsa033200.82852081
53Amoebiasis_Homo sapiens_hsa051460.80491254
54Hepatitis C_Homo sapiens_hsa051600.78930889
55Acute myeloid leukemia_Homo sapiens_hsa052210.77137175
56Chemokine signaling pathway_Homo sapiens_hsa040620.73634075
57Hepatitis B_Homo sapiens_hsa051610.73182645
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.72561153
59Type I diabetes mellitus_Homo sapiens_hsa049400.69430080
60Complement and coagulation cascades_Homo sapiens_hsa046100.67735307
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66161923
62Herpes simplex infection_Homo sapiens_hsa051680.65872866
63HIF-1 signaling pathway_Homo sapiens_hsa040660.64053272
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61366495
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.61185987
66Measles_Homo sapiens_hsa051620.59959334
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59444143
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58001664
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57071642
70Mineral absorption_Homo sapiens_hsa049780.55607060
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53256687
72Pancreatic cancer_Homo sapiens_hsa052120.52968996
73VEGF signaling pathway_Homo sapiens_hsa043700.50200622
74Endocytosis_Homo sapiens_hsa041440.49788806
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49773678
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.49561084
77Notch signaling pathway_Homo sapiens_hsa043300.48458347
78Synaptic vesicle cycle_Homo sapiens_hsa047210.48100615
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.46143798
80Chronic myeloid leukemia_Homo sapiens_hsa052200.45808969
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.45496016
82African trypanosomiasis_Homo sapiens_hsa051430.45116061
83Glutathione metabolism_Homo sapiens_hsa004800.44889359
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43569130
85Steroid biosynthesis_Homo sapiens_hsa001000.40557961
86Renin-angiotensin system_Homo sapiens_hsa046140.40242917
87Renal cell carcinoma_Homo sapiens_hsa052110.39236387
88Platelet activation_Homo sapiens_hsa046110.38929300
89Proteoglycans in cancer_Homo sapiens_hsa052050.37548685
90Epstein-Barr virus infection_Homo sapiens_hsa051690.37445697
91Type II diabetes mellitus_Homo sapiens_hsa049300.36315897
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35155309
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32612945
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.32594465
95Prolactin signaling pathway_Homo sapiens_hsa049170.30595371
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.29660150
97T cell receptor signaling pathway_Homo sapiens_hsa046600.28105139
98HTLV-I infection_Homo sapiens_hsa051660.27791565
99GnRH signaling pathway_Homo sapiens_hsa049120.24049016
100Insulin resistance_Homo sapiens_hsa049310.23681197

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