ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	4.56496332
2	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.30479113
3	regulation of cilium movement (GO:0003352)	4.20357231
4	epithelial cilium movement (GO:0003351)	4.15729691
5	cilium or flagellum-dependent cell motility (GO:0001539)	4.09776055
6	cilium movement (GO:0003341)	4.09614342
7	behavioral response to nicotine (GO:0035095)	4.06190229
8	nonmotile primary cilium assembly (GO:0035058)	4.01488285
9	postsynaptic membrane organization (GO:0001941)	3.95380806
10	axoneme assembly (GO:0035082)	3.82843435
11	pyrimidine nucleobase catabolic process (GO:0006208)	3.70823865
12	axonemal dynein complex assembly (GO:0070286)	3.56841725
13	protein localization to cilium (GO:0061512)	3.54130712
14	neuronal action potential propagation (GO:0019227)	3.47584921
15	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.44141064
16	protein polyglutamylation (GO:0018095)	3.37193980
17	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.35520496
18	transmission of nerve impulse (GO:0019226)	3.34736374
19	cilium morphogenesis (GO:0060271)	3.32893224
20	cilium organization (GO:0044782)	3.30621317
21	intraciliary transport (GO:0042073)	3.30322148
22	cilium assembly (GO:0042384)	3.26965619
23	cellular ketone body metabolic process (GO:0046950)	3.21495172
24	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.21154607
25	synaptic vesicle maturation (GO:0016188)	3.18326609
26	detection of light stimulus involved in visual perception (GO:0050908)	3.17375524
27	detection of light stimulus involved in sensory perception (GO:0050962)	3.17375524
28	nucleobase catabolic process (GO:0046113)	3.15056751
29	photoreceptor cell maintenance (GO:0045494)	3.13366214
30	dendritic spine morphogenesis (GO:0060997)	3.12733653
31	presynaptic membrane assembly (GO:0097105)	3.12511188
32	regulation of microtubule-based movement (GO:0060632)	3.09617505
33	protein localization to synapse (GO:0035418)	3.09176160
34	vocalization behavior (GO:0071625)	3.07315625
35	cellular biogenic amine catabolic process (GO:0042402)	3.07267638
36	amine catabolic process (GO:0009310)	3.07267638
37	indolalkylamine metabolic process (GO:0006586)	3.04734598
38	synaptic transmission, glutamatergic (GO:0035249)	3.03869158
39	response to pheromone (GO:0019236)	3.02632980
40	neuron cell-cell adhesion (GO:0007158)	3.01459937
41	kynurenine metabolic process (GO:0070189)	2.95743741
42	auditory behavior (GO:0031223)	2.93948391
43	presynaptic membrane organization (GO:0097090)	2.93211561
44	indolalkylamine catabolic process (GO:0046218)	2.91897725
45	tryptophan catabolic process (GO:0006569)	2.91897725
46	indole-containing compound catabolic process (GO:0042436)	2.91897725
47	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.91232119
48	behavioral response to ethanol (GO:0048149)	2.89374550
49	ketone body metabolic process (GO:1902224)	2.89345775
50	neural tube formation (GO:0001841)	2.83651357
51	reflex (GO:0060004)	2.80549487
52	membrane depolarization during action potential (GO:0086010)	2.80270677
53	central nervous system projection neuron axonogenesis (GO:0021952)	2.79528680
54	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.74527494
55	startle response (GO:0001964)	2.72616329
56	glycosphingolipid biosynthetic process (GO:0006688)	2.71415795
57	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.70040444
58	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.67143519
59	axonal fasciculation (GO:0007413)	2.65069955
60	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.64443659
61	regulation of collateral sprouting (GO:0048670)	2.63813408
62	central nervous system neuron axonogenesis (GO:0021955)	2.63080235
63	response to misfolded protein (GO:0051788)	2.62790576
64	neuron-neuron synaptic transmission (GO:0007270)	2.62724699
65	regulation of neurotransmitter uptake (GO:0051580)	2.62320320
66	cellular component assembly involved in morphogenesis (GO:0010927)	2.61135825
67	microtubule bundle formation (GO:0001578)	2.59482873
68	glutamate receptor signaling pathway (GO:0007215)	2.56793434
69	retinal cone cell development (GO:0046549)	2.56041659
70	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.54991036
71	C4-dicarboxylate transport (GO:0015740)	2.54712284
72	signal peptide processing (GO:0006465)	2.54619783
73	sperm motility (GO:0030317)	2.54580063
74	adult walking behavior (GO:0007628)	2.53680959
75	behavioral fear response (GO:0001662)	2.52639039
76	behavioral defense response (GO:0002209)	2.52639039
77	neuromuscular synaptic transmission (GO:0007274)	2.52501288
78	locomotory exploration behavior (GO:0035641)	2.52437296
79	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.51961151
80	retinal ganglion cell axon guidance (GO:0031290)	2.51930521
81	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.51282822
82	central nervous system myelination (GO:0022010)	2.51153198
83	axon ensheathment in central nervous system (GO:0032291)	2.51153198
84	appendage development (GO:0048736)	2.50972505
85	limb development (GO:0060173)	2.50972505
86	neuron recognition (GO:0008038)	2.50605563
87	inner ear receptor stereocilium organization (GO:0060122)	2.50226876
88	auditory receptor cell stereocilium organization (GO:0060088)	2.50067850
89	neuronal action potential (GO:0019228)	2.48812621
90	photoreceptor cell development (GO:0042461)	2.48810608
91	tryptophan metabolic process (GO:0006568)	2.47957391
92	regulation of action potential (GO:0098900)	2.47449003
93	smoothened signaling pathway (GO:0007224)	2.46649253
94	cornea development in camera-type eye (GO:0061303)	2.46264496
95	L-fucose catabolic process (GO:0042355)	2.44986942
96	fucose catabolic process (GO:0019317)	2.44986942
97	L-fucose metabolic process (GO:0042354)	2.44986942
98	tachykinin receptor signaling pathway (GO:0007217)	2.44313052
99	preassembly of GPI anchor in ER membrane (GO:0016254)	2.43610360
100	indole-containing compound metabolic process (GO:0042430)	2.42846996

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.45254735
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.42545046
3	VDR_22108803_ChIP-Seq_LS180_Human	3.25209989
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.85857481
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.75447717
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.59772548
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.56988121
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.52013784
9	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.18835339
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.18133556
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.17547514
12	REST_21632747_ChIP-Seq_MESCs_Mouse	2.10798262
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.97495985
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.94355938
15	FUS_26573619_Chip-Seq_HEK293_Human	1.92349162
16	P300_19829295_ChIP-Seq_ESCs_Human	1.90114054
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.87620629
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.83854350
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.80571627
20	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.79035789
21	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.74898533
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.67193297
23	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.65199091
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.62000376
25	RNF2_27304074_Chip-Seq_NSC_Mouse	1.61248286
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.60866279
27	EWS_26573619_Chip-Seq_HEK293_Human	1.59847634
28	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.56853778
29	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55962000
30	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55962000
31	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.55955430
32	STAT3_23295773_ChIP-Seq_U87_Human	1.54640915
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.53081065
34	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52001462
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51969852
36	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.51525395
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.51481399
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.49611634
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.47776781
40	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.45509935
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.45388193
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44491607
43	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.44315768
44	ER_23166858_ChIP-Seq_MCF-7_Human	1.44127230
45	AR_25329375_ChIP-Seq_VCAP_Human	1.42620287
46	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.42443765
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.42152116
48	* TCF4_23295773_ChIP-Seq_U87_Human	1.41840823
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41072767
50	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.40575751
51	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39444246
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.39036284
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.37467544
54	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.37467544
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35011723
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.33496088
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32963517
58	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.31901660
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25702318
60	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.24790102
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24649851
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.24186450
63	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.21847736
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.19928701
65	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19273699
66	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19196683
67	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19147995
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18431307
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17869917
70	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16694672
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.16000608
72	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.11954363
73	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.11735373
74	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09403239
75	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.09305871
76	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.08586847
77	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.08586847
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08252178
79	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.08206538
80	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.07278952
81	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.05988558
82	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05080353
83	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.03306084
84	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.03306084
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.02800084
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.00221041
87	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.99817537
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99003079
89	* PRDM14_20953172_ChIP-Seq_ESCs_Human	0.98237897
90	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.98022125
91	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.97782557
92	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.97648391
93	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.97561210
94	NCOR_22424771_ChIP-Seq_293T_Human	0.97086800
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.96254560
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96012131
97	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95140006
98	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.94243957
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.93938665
100	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.93051938

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.41414436
2	MP0006276_abnormal_autonomic_nervous	2.69219398
3	MP0001968_abnormal_touch/_nociception	2.68676840
4	MP0002736_abnormal_nociception_after	2.57424446
5	MP0005423_abnormal_somatic_nervous	2.56639354
6	MP0009046_muscle_twitch	2.49017947
7	MP0009745_abnormal_behavioral_response	2.38925945
8	MP0003136_yellow_coat_color	2.37896888
9	MP0001984_abnormal_olfaction	2.37497251
10	MP0004859_abnormal_synaptic_plasticity	2.26778546
11	MP0005551_abnormal_eye_electrophysiolog	2.19467021
12	MP0002653_abnormal_ependyma_morphology	2.19061937
13	MP0004142_abnormal_muscle_tone	2.10054995
14	MP0001486_abnormal_startle_reflex	2.08048681
15	MP0002272_abnormal_nervous_system	2.07267417
16	MP0003635_abnormal_synaptic_transmissio	2.05678732
17	MP0002572_abnormal_emotion/affect_behav	2.00157085
18	MP0000569_abnormal_digit_pigmentation	1.96952316
19	MP0002735_abnormal_chemical_nociception	1.93506446
20	MP0002064_seizures	1.93115213
21	MP0001501_abnormal_sleep_pattern	1.91668603
22	MP0001529_abnormal_vocalization	1.87232276
23	MP0003122_maternal_imprinting	1.84852093
24	MP0002063_abnormal_learning/memory/cond	1.82306685
25	MP0003787_abnormal_imprinting	1.78620362
26	MP0002638_abnormal_pupillary_reflex	1.78408574
27	MP0000778_abnormal_nervous_system	1.77052269
28	MP0002734_abnormal_mechanical_nocicepti	1.71466722
29	MP0005646_abnormal_pituitary_gland	1.70656774
30	MP0006292_abnormal_olfactory_placode	1.70319265
31	MP0001970_abnormal_pain_threshold	1.70249606
32	MP0008789_abnormal_olfactory_epithelium	1.66710778
33	MP0002557_abnormal_social/conspecific_i	1.64137155
34	MP0005499_abnormal_olfactory_system	1.62419479
35	MP0005394_taste/olfaction_phenotype	1.62419479
36	MP0002733_abnormal_thermal_nociception	1.58616842
37	MP0002102_abnormal_ear_morphology	1.55329323
38	MP0002067_abnormal_sensory_capabilities	1.54398458
39	MP0001485_abnormal_pinna_reflex	1.53857279
40	MP0005645_abnormal_hypothalamus_physiol	1.53522019
41	MP0005253_abnormal_eye_physiology	1.53424242
42	MP0000372_irregular_coat_pigmentation	1.52918786
43	MP0008877_abnormal_DNA_methylation	1.51536036
44	MP0004133_heterotaxia	1.42058816
45	MP0002938_white_spotting	1.39487518
46	MP0001905_abnormal_dopamine_level	1.39310690
47	MP0003121_genomic_imprinting	1.38423810
48	MP0002822_catalepsy	1.37259254
49	MP0003878_abnormal_ear_physiology	1.34446440
50	MP0005377_hearing/vestibular/ear_phenot	1.34446440
51	MP0000631_abnormal_neuroendocrine_gland	1.34274057
52	MP0004270_analgesia	1.33514917
53	MP0001986_abnormal_taste_sensitivity	1.33488830
54	MP0010386_abnormal_urinary_bladder	1.28332120
55	MP0006072_abnormal_retinal_apoptosis	1.26625945
56	MP0002184_abnormal_innervation	1.25957747
57	MP0003195_calcinosis	1.25702863
58	MP0008872_abnormal_physiological_respon	1.23562038
59	MP0005171_absent_coat_pigmentation	1.23119709
60	MP0004885_abnormal_endolymph	1.22854682
61	MP0002882_abnormal_neuron_morphology	1.21598531
62	MP0000955_abnormal_spinal_cord	1.20327937
63	MP0004043_abnormal_pH_regulation	1.19871293
64	MP0001440_abnormal_grooming_behavior	1.19743489
65	MP0004924_abnormal_behavior	1.19279573
66	MP0005386_behavior/neurological_phenoty	1.19279573
67	MP0000026_abnormal_inner_ear	1.15704757
68	MP0003011_delayed_dark_adaptation	1.15479480
69	MP0002752_abnormal_somatic_nervous	1.13491986
70	MP0001963_abnormal_hearing_physiology	1.12929574
71	MP0005174_abnormal_tail_pigmentation	1.11532615
72	MP0005410_abnormal_fertilization	1.03623461
73	MP0004742_abnormal_vestibular_system	1.02850025
74	MP0002837_dystrophic_cardiac_calcinosis	1.02846013
75	MP0003879_abnormal_hair_cell	1.02485821
76	MP0002928_abnormal_bile_duct	1.00300058
77	MP0004147_increased_porphyrin_level	1.00063132
78	MP0002229_neurodegeneration	0.98024429
79	MP0002909_abnormal_adrenal_gland	0.94853357
80	MP0003698_abnormal_male_reproductive	0.91923127
81	MP0000427_abnormal_hair_cycle	0.91881358
82	MP0002066_abnormal_motor_capabilities/c	0.91277040
83	MP0003137_abnormal_impulse_conducting	0.90256898
84	MP0002152_abnormal_brain_morphology	0.90050435
85	MP0005195_abnormal_posterior_eye	0.89491815
86	MP0003119_abnormal_digestive_system	0.88577042
87	MP0002234_abnormal_pharynx_morphology	0.88245143
88	MP0005670_abnormal_white_adipose	0.86721835
89	MP0004811_abnormal_neuron_physiology	0.85115746
90	MP0004145_abnormal_muscle_electrophysio	0.84787948
91	MP0001502_abnormal_circadian_rhythm	0.84453440
92	MP0002751_abnormal_autonomic_nervous	0.82931786
93	MP0008569_lethality_at_weaning	0.82590732
94	MP0003633_abnormal_nervous_system	0.80535112
95	MP0008995_early_reproductive_senescence	0.79194309
96	MP0002876_abnormal_thyroid_physiology	0.78003429
97	MP0003646_muscle_fatigue	0.77562575
98	MP0004858_abnormal_nervous_system	0.77371672
99	MP0000049_abnormal_middle_ear	0.72484976
100	MP0002095_abnormal_skin_pigmentation	0.72411543

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.51100907
2	Pancreatic cysts (HP:0001737)	4.48577664
3	Pancreatic fibrosis (HP:0100732)	4.44483010
4	Molar tooth sign on MRI (HP:0002419)	3.94046174
5	Abnormality of midbrain morphology (HP:0002418)	3.94046174
6	Progressive cerebellar ataxia (HP:0002073)	3.93298097
7	Genetic anticipation (HP:0003743)	3.92496481
8	Medial flaring of the eyebrow (HP:0010747)	3.81501821
9	Nephronophthisis (HP:0000090)	3.79030444
10	Gait imbalance (HP:0002141)	3.72673767
11	Cystic liver disease (HP:0006706)	3.45672204
12	Congenital primary aphakia (HP:0007707)	3.43070558
13	Focal motor seizures (HP:0011153)	3.40764420
14	Abnormal ciliary motility (HP:0012262)	3.35731186
15	Nephrogenic diabetes insipidus (HP:0009806)	3.26769338
16	Abnormality of the renal medulla (HP:0100957)	3.22833252
17	Abnormal respiratory motile cilium morphology (HP:0005938)	3.15528135
18	Abnormal respiratory epithelium morphology (HP:0012253)	3.15528135
19	Absent/shortened dynein arms (HP:0200106)	3.14104868
20	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.14104868
21	Sclerocornea (HP:0000647)	3.12182926
22	Abnormal respiratory motile cilium physiology (HP:0012261)	3.09460269
23	Focal seizures (HP:0007359)	3.08725257
24	Gaze-evoked nystagmus (HP:0000640)	3.08705324
25	Hyperventilation (HP:0002883)	3.05114985
26	Congenital stationary night blindness (HP:0007642)	2.99872017
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.96935659
28	Febrile seizures (HP:0002373)	2.90697183
29	Chronic hepatic failure (HP:0100626)	2.90196569
30	Myokymia (HP:0002411)	2.86954815
31	Vaginal atresia (HP:0000148)	2.80075007
32	Polyphagia (HP:0002591)	2.79030449
33	Genital tract atresia (HP:0001827)	2.78538618
34	Tubulointerstitial nephritis (HP:0001970)	2.71916795
35	Dialeptic seizures (HP:0011146)	2.70177873
36	Abnormality of the labia minora (HP:0012880)	2.69690661
37	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.66313741
38	Retinal dysplasia (HP:0007973)	2.66220180
39	Atonic seizures (HP:0010819)	2.65485608
40	Absence seizures (HP:0002121)	2.63443815
41	Postaxial foot polydactyly (HP:0001830)	2.60870956
42	Poor coordination (HP:0002370)	2.50900677
43	Hemiparesis (HP:0001269)	2.50643041
44	Attenuation of retinal blood vessels (HP:0007843)	2.46647213
45	Congenital hepatic fibrosis (HP:0002612)	2.45346568
46	Abnormal drinking behavior (HP:0030082)	2.45221752
47	Polydipsia (HP:0001959)	2.45221752
48	Anencephaly (HP:0002323)	2.44579211
49	Abnormality of the renal cortex (HP:0011035)	2.43637055
50	Occipital encephalocele (HP:0002085)	2.42149048
51	Rhinitis (HP:0012384)	2.40058862
52	Failure to thrive in infancy (HP:0001531)	2.34460105
53	Absent speech (HP:0001344)	2.31729237
54	Type II lissencephaly (HP:0007260)	2.29910896
55	Bony spicule pigmentary retinopathy (HP:0007737)	2.27492772
56	Decreased central vision (HP:0007663)	2.24836868
57	Epileptic encephalopathy (HP:0200134)	2.22106485
58	Pendular nystagmus (HP:0012043)	2.18977702
59	Specific learning disability (HP:0001328)	2.17301359
60	Male pseudohermaphroditism (HP:0000037)	2.16762947
61	Retinitis pigmentosa (HP:0000510)	2.16719882
62	Tubular atrophy (HP:0000092)	2.16705780
63	Broad-based gait (HP:0002136)	2.13985624
64	Postaxial hand polydactyly (HP:0001162)	2.11363940
65	Abnormality of macular pigmentation (HP:0008002)	2.08480716
66	Lissencephaly (HP:0001339)	2.06706874
67	Preaxial hand polydactyly (HP:0001177)	2.06061134
68	Abnormal rod and cone electroretinograms (HP:0008323)	2.04933678
69	Aplasia/Hypoplasia of the lens (HP:0008063)	2.02239970
70	Abolished electroretinogram (ERG) (HP:0000550)	2.00667913
71	Increased corneal curvature (HP:0100692)	1.94986532
72	Keratoconus (HP:0000563)	1.94986532
73	Narrow forehead (HP:0000341)	1.90027806
74	Furrowed tongue (HP:0000221)	1.87158750
75	Broad foot (HP:0001769)	1.86142654
76	Cerebellar dysplasia (HP:0007033)	1.85202335
77	Acute necrotizing encephalopathy (HP:0006965)	1.83812307
78	Urinary bladder sphincter dysfunction (HP:0002839)	1.81487054
79	Polyuria (HP:0000103)	1.80712656
80	Tubulointerstitial abnormality (HP:0001969)	1.80503397
81	Aganglionic megacolon (HP:0002251)	1.80471126
82	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.78161463
83	Bile duct proliferation (HP:0001408)	1.77750928
84	Abnormal biliary tract physiology (HP:0012439)	1.77750928
85	Severe visual impairment (HP:0001141)	1.77538861
86	Abnormality of binocular vision (HP:0011514)	1.76105320
87	Diplopia (HP:0000651)	1.76105320
88	Hyperglycinemia (HP:0002154)	1.76075981
89	Epileptiform EEG discharges (HP:0011182)	1.75723497
90	Short foot (HP:0001773)	1.75262959
91	Limb dystonia (HP:0002451)	1.74468376
92	EEG with generalized epileptiform discharges (HP:0011198)	1.74093675
93	Hypsarrhythmia (HP:0002521)	1.73997247
94	Drooling (HP:0002307)	1.71077602
95	Astigmatism (HP:0000483)	1.70387237
96	Multicystic kidney dysplasia (HP:0000003)	1.70227010
97	Agitation (HP:0000713)	1.69620928
98	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.69066107
99	Hip dysplasia (HP:0001385)	1.68186175
100	Inability to walk (HP:0002540)	1.67390355

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.87695508
2	MAP4K2	3.65312018
3	MARK1	2.89647326
4	CASK	2.83316274
5	MAPK13	2.55847811
6	WNK3	2.28820601
7	PINK1	2.26241238
8	INSRR	2.24692853
9	EPHA4	2.24066382
10	BMPR1B	2.19937791
11	ADRBK2	2.12057360
12	MAP3K4	2.10813912
13	CDK19	1.87047805
14	NTRK3	1.79417063
15	MAP2K7	1.77664338
16	OXSR1	1.65592178
17	BCR	1.61121095
18	DYRK2	1.59859810
19	GRK1	1.56873941
20	PLK2	1.54307849
21	MAPK15	1.47154451
22	NTRK2	1.44428751
23	WNK4	1.42867077
24	DAPK2	1.42262035
25	PAK3	1.40645225
26	NUAK1	1.38480711
27	PRKCG	1.33493734
28	STK39	1.32247833
29	TRIM28	1.28247007
30	CSNK1G2	1.26900504
31	CSNK1A1L	1.22886875
32	CSNK1G3	1.20227994
33	PRKD3	1.15652574
34	ZAK	1.15076991
35	MINK1	1.10346068
36	ADRBK1	1.07256459
37	BCKDK	1.04354755
38	PRKCE	1.02737051
39	PKN1	1.01104107
40	CSNK1G1	1.00960686
41	ACVR1B	1.00675353
42	TNIK	0.98836855
43	CAMK1	0.92744526
44	MKNK2	0.90123526
45	PNCK	0.87355269
46	DYRK1A	0.84667423
47	PHKG1	0.83945684
48	PHKG2	0.83945684
49	NME1	0.83138113
50	CAMK2A	0.78826544
51	PAK6	0.76773671
52	ERBB3	0.75791072
53	STK16	0.74720089
54	TNK2	0.73001710
55	FER	0.72020917
56	FGFR2	0.70470462
57	TLK1	0.70359207
58	SIK2	0.69517136
59	STK38L	0.68033707
60	EPHA3	0.66214112
61	ERBB2	0.63453704
62	CDK5	0.61362202
63	MAP2K4	0.59593885
64	UHMK1	0.58962451
65	MKNK1	0.56330302
66	LMTK2	0.55683715
67	CSNK1A1	0.55648987
68	STK11	0.55150368
69	PTK2B	0.53230714
70	VRK1	0.53143274
71	PRKCZ	0.52865339
72	TAOK3	0.52858586
73	PRKACA	0.52771572
74	GRK5	0.51131285
75	MAPKAPK5	0.50168905
76	VRK2	0.49650653
77	MUSK	0.49188049
78	CSNK1D	0.47636768
79	PRKAA1	0.45512274
80	CAMK1G	0.42590301
81	PIK3CA	0.41307648
82	PRKACB	0.40413468
83	PRKCA	0.40251383
84	PLK4	0.39186700
85	CAMKK2	0.38295232
86	PRKCQ	0.37759988
87	MAP3K7	0.37375394
88	LIMK1	0.37093799
89	PRKCH	0.35344427
90	PLK1	0.34748916
91	DYRK3	0.34531453
92	PRKG1	0.34478580
93	RPS6KA5	0.34182894
94	TGFBR1	0.34156802
95	SGK223	0.31681334
96	SGK494	0.31681334
97	CAMK2B	0.31009345
98	PRKCI	0.30663972
99	EPHB2	0.29483483
100	CAMK4	0.29302547

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.49191292
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.11720349
3	Butanoate metabolism_Homo sapiens_hsa00650	2.65731751
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.45225900
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.40091834
6	Phototransduction_Homo sapiens_hsa04744	2.30432131
7	Morphine addiction_Homo sapiens_hsa05032	2.12600236
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.11370405
9	GABAergic synapse_Homo sapiens_hsa04727	2.09010691
10	Taste transduction_Homo sapiens_hsa04742	1.94339443
11	Oxidative phosphorylation_Homo sapiens_hsa00190	1.92719361
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.92049009
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84494390
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.76325098
15	Circadian entrainment_Homo sapiens_hsa04713	1.73724684
16	Sulfur relay system_Homo sapiens_hsa04122	1.67936818
17	Glutamatergic synapse_Homo sapiens_hsa04724	1.66324174
18	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66231401
19	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.65478858
20	Nitrogen metabolism_Homo sapiens_hsa00910	1.64490052
21	Parkinsons disease_Homo sapiens_hsa05012	1.59832508
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54967384
23	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.54963035
24	Propanoate metabolism_Homo sapiens_hsa00640	1.54168266
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.50229933
26	Insulin secretion_Homo sapiens_hsa04911	1.49991546
27	RNA polymerase_Homo sapiens_hsa03020	1.46690290
28	Huntingtons disease_Homo sapiens_hsa05016	1.46513814
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.45595471
30	Olfactory transduction_Homo sapiens_hsa04740	1.45492532
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.39517629
32	Homologous recombination_Homo sapiens_hsa03440	1.35516940
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32302173
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.28827685
35	Serotonergic synapse_Homo sapiens_hsa04726	1.27029012
36	Dopaminergic synapse_Homo sapiens_hsa04728	1.23478565
37	Fanconi anemia pathway_Homo sapiens_hsa03460	1.20833726
38	Salivary secretion_Homo sapiens_hsa04970	1.17882023
39	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17261108
40	Peroxisome_Homo sapiens_hsa04146	1.11387168
41	Alzheimers disease_Homo sapiens_hsa05010	1.08584612
42	Cocaine addiction_Homo sapiens_hsa05030	1.08221267
43	Calcium signaling pathway_Homo sapiens_hsa04020	1.06272498
44	ABC transporters_Homo sapiens_hsa02010	1.05430100
45	Ether lipid metabolism_Homo sapiens_hsa00565	1.04360877
46	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.04280281
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99254662
48	Amphetamine addiction_Homo sapiens_hsa05031	0.98060363
49	Cholinergic synapse_Homo sapiens_hsa04725	0.95828525
50	Protein export_Homo sapiens_hsa03060	0.93822274
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.93537900
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.92719335
53	Regulation of autophagy_Homo sapiens_hsa04140	0.89679048
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88482534
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86316320
56	Basal transcription factors_Homo sapiens_hsa03022	0.84565327
57	Gastric acid secretion_Homo sapiens_hsa04971	0.83987586
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81883571
59	Retinol metabolism_Homo sapiens_hsa00830	0.78684806
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.78633137
61	Purine metabolism_Homo sapiens_hsa00230	0.78362051
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77985632
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72294506
64	Axon guidance_Homo sapiens_hsa04360	0.71935670
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.68570935
66	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.68340207
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.67790326
68	Metabolic pathways_Homo sapiens_hsa01100	0.65728363
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65320829
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.65149418
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.64462893
72	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.62708028
73	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.59306271
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56385213
75	Selenocompound metabolism_Homo sapiens_hsa00450	0.56018551
76	Long-term depression_Homo sapiens_hsa04730	0.55788150
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.55330052
78	Histidine metabolism_Homo sapiens_hsa00340	0.53638062
79	Lysine degradation_Homo sapiens_hsa00310	0.53509390
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53004360
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52549882
82	Fatty acid elongation_Homo sapiens_hsa00062	0.52479342
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49534339
84	Caffeine metabolism_Homo sapiens_hsa00232	0.48596663
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48434278
86	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.47674305
87	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47343635
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.45118620
89	Circadian rhythm_Homo sapiens_hsa04710	0.44757297
90	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.44703756
91	Fatty acid degradation_Homo sapiens_hsa00071	0.44088242
92	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.42896536
93	Renin secretion_Homo sapiens_hsa04924	0.42114745
94	Basal cell carcinoma_Homo sapiens_hsa05217	0.41431832
95	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41180133
96	Oocyte meiosis_Homo sapiens_hsa04114	0.40702298
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40640292
98	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.40325916
99	RNA degradation_Homo sapiens_hsa03018	0.38848694
100	Alcoholism_Homo sapiens_hsa05034	0.38180801

C11ORF49

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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