ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sensory perception of taste (GO:0050909)	8.43225708
2	regulation of female receptivity (GO:0045924)	8.31488893
3	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	8.19141975
4	female mating behavior (GO:0060180)	7.07544976
5	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	6.88842785
6	long term synaptic depression (GO:0060292)	6.46445940
7	synaptic transmission, dopaminergic (GO:0001963)	5.54868367
8	negative regulation by host of viral transcription (GO:0043922)	5.27659076
9	dendritic spine morphogenesis (GO:0060997)	5.07570270
10	negative regulation of execution phase of apoptosis (GO:1900118)	5.00866701
11	aminoglycoside antibiotic metabolic process (GO:0030647)	4.77403789
12	transmission of nerve impulse (GO:0019226)	4.56966709
13	inositol phosphate dephosphorylation (GO:0046855)	4.16482621
14	phosphorylated carbohydrate dephosphorylation (GO:0046838)	4.16482621
15	regulation of ARF protein signal transduction (GO:0032012)	4.00297782
16	multicellular organismal reproductive behavior (GO:0033057)	3.96122958
17	glycoside metabolic process (GO:0016137)	3.91337479
18	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.84653235
19	endocrine process (GO:0050886)	3.84653235
20	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.84653235
21	auditory receptor cell differentiation (GO:0042491)	3.76405829
22	polyketide metabolic process (GO:0030638)	3.75140637
23	doxorubicin metabolic process (GO:0044598)	3.75140637
24	daunorubicin metabolic process (GO:0044597)	3.75140637
25	piRNA metabolic process (GO:0034587)	3.73795471
26	DNA methylation involved in gamete generation (GO:0043046)	3.72702047
27	dendritic spine organization (GO:0097061)	3.69757100
28	response to monoamine (GO:0071867)	3.68113344
29	response to catecholamine (GO:0071869)	3.68113344
30	sensory perception of chemical stimulus (GO:0007606)	3.67886432
31	myelin maintenance (GO:0043217)	3.66615796
32	inositol phosphate catabolic process (GO:0071545)	3.63427453
33	cellular response to catecholamine stimulus (GO:0071870)	3.56583061
34	cellular response to monoamine stimulus (GO:0071868)	3.56583061
35	phospholipid dephosphorylation (GO:0046839)	3.55174992
36	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.52712471
37	histone H2A acetylation (GO:0043968)	3.50256021
38	retinol metabolic process (GO:0042572)	3.46537259
39	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.45832230
40	positive regulation of histone H3-K4 methylation (GO:0051571)	3.45510507
41	vesicle targeting (GO:0006903)	3.43213935
42	cAMP catabolic process (GO:0006198)	3.42475546
43	modulation by host of symbiont transcription (GO:0052472)	3.40405525
44	modulation by host of viral transcription (GO:0043921)	3.40405525
45	phosphatidylinositol dephosphorylation (GO:0046856)	3.39650081
46	actin filament capping (GO:0051693)	3.32351585
47	regulation of hydrogen peroxide metabolic process (GO:0010310)	3.32109895
48	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	3.26983113
49	regulation of systemic arterial blood pressure (GO:0003073)	3.25567494
50	negative regulation of cAMP-mediated signaling (GO:0043951)	3.23457965
51	positive regulation of calcium ion import (GO:0090280)	3.23044636
52	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	3.22418867
53	positive regulation of gluconeogenesis (GO:0045722)	3.21875152
54	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	3.21499004
55	response to amphetamine (GO:0001975)	3.19952140
56	neuron fate specification (GO:0048665)	3.19797895
57	cyclic nucleotide catabolic process (GO:0009214)	3.19244066
58	polyol catabolic process (GO:0046174)	3.16976275
59	termination of G-protein coupled receptor signaling pathway (GO:0038032)	3.14724028
60	membrane repolarization during action potential (GO:0086011)	3.13037625
61	protein localization to cilium (GO:0061512)	3.12273418
62	termination of signal transduction (GO:0023021)	3.07309688
63	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.03581580
64	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.03581580
65	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.03581580
66	phosphate ion transport (GO:0006817)	2.95821794
67	nephron tubule morphogenesis (GO:0072078)	2.94114725
68	nephron epithelium morphogenesis (GO:0072088)	2.94114725
69	nephron tubule formation (GO:0072079)	2.93922893
70	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.92961934
71	neuronal action potential (GO:0019228)	2.92703738
72	L-alpha-amino acid transmembrane transport (GO:1902475)	2.92483186
73	multicellular organismal signaling (GO:0035637)	2.89038391
74	ethanol oxidation (GO:0006069)	2.88079109
75	CDP-diacylglycerol metabolic process (GO:0046341)	2.86032796
76	potassium ion transmembrane transport (GO:0071805)	2.78513110
77	cellular potassium ion transport (GO:0071804)	2.78513110
78	microtubule severing (GO:0051013)	2.78365316
79	cilium morphogenesis (GO:0060271)	2.74923249
80	negative regulation of cell size (GO:0045792)	2.74648816
81	peptide hormone processing (GO:0016486)	2.74648542
82	regulation of skeletal muscle contraction (GO:0014819)	2.69878538
83	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	2.69422101
84	renal absorption (GO:0070293)	2.67520099
85	arachidonic acid secretion (GO:0050482)	2.65013806
86	icosanoid secretion (GO:0032309)	2.65013806
87	epithelial cell fate commitment (GO:0072148)	2.64475031
88	regulation of vacuole organization (GO:0044088)	2.64005542
89	negative regulation of actin filament depolymerization (GO:0030835)	2.63625769
90	mitochondrion degradation (GO:0000422)	2.62454879
91	glomerular epithelial cell development (GO:0072310)	2.61836464
92	insulin secretion (GO:0030073)	2.61690980
93	multi-organism reproductive behavior (GO:0044705)	2.61072121
94	water-soluble vitamin biosynthetic process (GO:0042364)	2.60434404
95	positive regulation of protein homooligomerization (GO:0032464)	2.58672081
96	potassium ion transport (GO:0006813)	2.58104622
97	glomerular visceral epithelial cell development (GO:0072015)	2.56665550
98	prepulse inhibition (GO:0060134)	2.55016772
99	digestion (GO:0007586)	2.54969206
100	potassium ion export (GO:0071435)	2.52960937

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.33573683
2	GATA1_22025678_ChIP-Seq_K562_Human	5.91412914
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.15387944
4	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.54221962
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10506673
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03795352
7	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.91654884
8	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.82621291
9	CTCF_27219007_Chip-Seq_Bcells_Human	1.79314592
10	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.74157891
11	* PIAS1_25552417_ChIP-Seq_VCAP_Human	1.71074940
12	STAT1_20625510_ChIP-Seq_HELA_Human	1.63655865
13	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56873858
14	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.53822884
15	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.53256270
16	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.50864758
17	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.45720205
18	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.44248727
19	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.42902559
20	CDX2_22108803_ChIP-Seq_LS180_Human	1.39518545
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39477007
22	SOX2_20726797_ChIP-Seq_SW620_Human	1.38041131
23	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.36250077
24	CBP_21632823_ChIP-Seq_H3396_Human	1.35444229
25	GATA6_25053715_ChIP-Seq_YYC3_Human	1.33469413
26	* FOXA1_25552417_ChIP-Seq_VCAP_Human	1.29020557
27	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.27042657
28	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.22996296
29	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.22975714
30	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.21807830
31	HTT_18923047_ChIP-ChIP_STHdh_Human	1.21303653
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.19745295
33	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.15594444
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.14128552
35	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.13887934
36	STAT1_17558387_ChIP-Seq_HELA_Human	1.13307676
37	GATA4_25053715_ChIP-Seq_YYC3_Human	1.12897317
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.12830912
39	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11829442
40	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.11141426
41	* SA1_27219007_Chip-Seq_Bcells_Human	1.10121646
42	NCOR_22424771_ChIP-Seq_293T_Human	1.07233879
43	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06582761
44	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06582761
45	SMC4_20622854_ChIP-Seq_HELA_Human	1.06230525
46	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.05901906
47	FLI1_21867929_ChIP-Seq_CD8_Mouse	1.03601673
48	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.03288945
49	HOXB7_26014856_ChIP-Seq_BT474_Human	1.02790648
50	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.02514989
51	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.02404669
52	ERG_20517297_ChIP-Seq_VCAP_Human	1.01632601
53	BCL6_27268052_Chip-Seq_Bcells_Human	1.01365153
54	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01225623
55	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.00372512
56	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.00319528
57	TCF4_22108803_ChIP-Seq_LS180_Human	0.98620581
58	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.98422666
59	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.97425705
60	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.96390053
61	IGF1R_20145208_ChIP-Seq_DFB_Human	0.95863863
62	P68_20966046_ChIP-Seq_HELA_Human	0.95521968
63	AHR_22903824_ChIP-Seq_MCF-7_Human	0.94511400
64	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.93394866
65	* SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93215016
66	RAC3_21632823_ChIP-Seq_H3396_Human	0.92928794
67	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.92360044
68	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.91685971
69	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.91255341
70	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90999496
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90435917
72	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.90080739
73	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.89019603
74	* AR_25329375_ChIP-Seq_VCAP_Human	0.88609254
75	FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.88203815
76	P300_27268052_Chip-Seq_Bcells_Human	0.87590743
77	MYC_19829295_ChIP-Seq_ESCs_Human	0.85636604
78	SOX2_18555785_Chip-Seq_ESCs_Mouse	0.84775502
79	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.84535046
80	AR_20517297_ChIP-Seq_VCAP_Human	0.84514246
81	CTCF_21964334_Chip-Seq_Bcells_Human	0.84456612
82	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.83813226
83	RACK7_27058665_Chip-Seq_MCF-7_Human	0.83752954
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.83296188
85	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.83137194
86	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82461614
87	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.82399243
88	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.81646342
89	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.81535453
90	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.80699262
91	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.79866891
92	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.78770913
93	PHF8_20622854_ChIP-Seq_HELA_Human	0.78526191
94	RBPJ_21746931_ChIP-Seq_IB4_Human	0.78441728
95	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.78248927
96	CEBPB_22108803_ChIP-Seq_LS180_Human	0.77342070
97	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.77341620
98	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.77296316
99	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.77133514
100	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.76745906

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005645_abnormal_hypothalamus_physiol	7.50738308
2	MP0010234_abnormal_vibrissa_follicle	5.41153418
3	MP0004858_abnormal_nervous_system	5.09521300
4	MP0002139_abnormal_hepatobiliary_system	4.65344364
5	MP0001986_abnormal_taste_sensitivity	4.51997346
6	MP0002909_abnormal_adrenal_gland	4.01086798
7	MP0002837_dystrophic_cardiac_calcinosis	3.93720373
8	MP0003787_abnormal_imprinting	3.34148333
9	MP0005423_abnormal_somatic_nervous	2.89494030
10	MP0003879_abnormal_hair_cell	2.87207001
11	MP0009780_abnormal_chondrocyte_physiolo	2.79281894
12	MP0003878_abnormal_ear_physiology	2.53362384
13	MP0005377_hearing/vestibular/ear_phenot	2.53362384
14	MP0003123_paternal_imprinting	2.44046006
15	MP0002138_abnormal_hepatobiliary_system	2.41351804
16	MP0005379_endocrine/exocrine_gland_phen	2.41348136
17	MP0008057_abnormal_DNA_replication	1.86799054
18	MP0008877_abnormal_DNA_methylation	1.79350361
19	MP0006276_abnormal_autonomic_nervous	1.77698010
20	MP0009046_muscle_twitch	1.72249164
21	MP0000003_abnormal_adipose_tissue	1.63389884
22	MP0010352_gastrointestinal_tract_polyps	1.62113382
23	MP0005367_renal/urinary_system_phenotyp	1.61385208
24	MP0000516_abnormal_urinary_system	1.61385208
25	MP0005220_abnormal_exocrine_pancreas	1.55651126
26	MP0002254_reproductive_system_inflammat	1.51462085
27	MP0001485_abnormal_pinna_reflex	1.50879239
28	MP0004019_abnormal_vitamin_homeostasis	1.46515755
29	MP0001944_abnormal_pancreas_morphology	1.41668900
30	MP0005365_abnormal_bile_salt	1.36853704
31	MP0006036_abnormal_mitochondrial_physio	1.31805473
32	MP0000013_abnormal_adipose_tissue	1.31621610
33	MP0006072_abnormal_retinal_apoptosis	1.31298593
34	MP0002166_altered_tumor_susceptibility	1.29755329
35	MP0000631_abnormal_neuroendocrine_gland	1.24863591
36	MP0002163_abnormal_gland_morphology	1.21364079
37	MP0003868_abnormal_feces_composition	1.19176698
38	MP0010386_abnormal_urinary_bladder	1.15808597
39	MP0002693_abnormal_pancreas_physiology	1.12407675
40	MP0005310_abnormal_salivary_gland	1.12327209
41	MP0000026_abnormal_inner_ear	1.10123425
42	MP0010678_abnormal_skin_adnexa	1.08705040
43	MP0000538_abnormal_urinary_bladder	1.05626886
44	MP0001666_abnormal_nutrient_absorption	1.05413575
45	MP0001664_abnormal_digestion	1.04259864
46	MP0000678_abnormal_parathyroid_gland	1.04051508
47	MP0005375_adipose_tissue_phenotype	1.03469711
48	MP0001348_abnormal_lacrimal_gland	1.01324440
49	MP0010329_abnormal_lipoprotein_level	1.01312426
50	MP0004145_abnormal_muscle_electrophysio	0.98852241
51	MP0002078_abnormal_glucose_homeostasis	0.97034980
52	MP0001756_abnormal_urination	0.93138325
53	MP0005448_abnormal_energy_balance	0.92122720
54	MP0004885_abnormal_endolymph	0.89525961
55	MP0001984_abnormal_olfaction	0.88264054
56	MP0004270_analgesia	0.86902164
57	MP0006035_abnormal_mitochondrial_morpho	0.84316539
58	MP0004036_abnormal_muscle_relaxation	0.84142341
59	MP0009643_abnormal_urine_homeostasis	0.81854701
60	MP0003953_abnormal_hormone_level	0.79896366
61	MP0004215_abnormal_myocardial_fiber	0.78303849
62	MP0004043_abnormal_pH_regulation	0.78210736
63	MP0005646_abnormal_pituitary_gland	0.77726003
64	MP0000230_abnormal_systemic_arterial	0.76553096
65	MP0008875_abnormal_xenobiotic_pharmacok	0.75033366
66	MP0002006_tumorigenesis	0.74797836
67	MP0005332_abnormal_amino_acid	0.72203402
68	MP0005647_abnormal_sex_gland	0.70833400
69	MP0001661_extended_life_span	0.70536296
70	MP0002136_abnormal_kidney_physiology	0.70326825
71	MP0005397_hematopoietic_system_phenotyp	0.69589662
72	MP0001545_abnormal_hematopoietic_system	0.69589662
73	MP0005084_abnormal_gallbladder_morpholo	0.69074256
74	MP0001765_abnormal_ion_homeostasis	0.69017633
75	MP0005551_abnormal_eye_electrophysiolog	0.66373343
76	MP0005319_abnormal_enzyme/_coenzyme	0.66000184
77	MP0001905_abnormal_dopamine_level	0.64526973
78	MP0003121_genomic_imprinting	0.60704581
79	MP0003646_muscle_fatigue	0.60616313
80	MP0005636_abnormal_mineral_homeostasis	0.60516625
81	MP0002229_neurodegeneration	0.60375071
82	MP0000427_abnormal_hair_cycle	0.59656671
83	MP0002118_abnormal_lipid_homeostasis	0.59568791
84	MP0005266_abnormal_metabolism	0.59347337
85	MP0008004_abnormal_stomach_pH	0.58999261
86	MP0002876_abnormal_thyroid_physiology	0.57008086
87	MP0002269_muscular_atrophy	0.56855621
88	MP0005248_abnormal_Harderian_gland	0.55918096
89	MP0002332_abnormal_exercise_endurance	0.55824269
90	MP0003075_altered_response_to	0.52202100
91	MP0002160_abnormal_reproductive_system	0.50900894
92	MP0002009_preneoplasia	0.50833901
93	MP0005666_abnormal_adipose_tissue	0.48973328
94	MP0001764_abnormal_homeostasis	0.48717303
95	MP0005535_abnormal_body_temperature	0.47969393
96	MP0005253_abnormal_eye_physiology	0.47955095
97	MP0004510_myositis	0.47049087
98	MP0001216_abnormal_epidermal_layer	0.46939332
99	MP0005334_abnormal_fat_pad	0.46790711
100	MP0002069_abnormal_eating/drinking_beha	0.46418089

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pigmentary retinal degeneration (HP:0001146)	6.94863230
2	Urethral obstruction (HP:0000796)	5.21770782
3	Severe visual impairment (HP:0001141)	4.78021147
4	Hypoplasia of the uterus (HP:0000013)	4.49350705
5	Hyperthyroidism (HP:0000836)	4.17844990
6	Enlarged penis (HP:0000040)	3.97699930
7	Aplasia/hypoplasia of the uterus (HP:0008684)	3.96479685
8	Abnormality of the vitreous humor (HP:0004327)	3.79531371
9	Abnormality of lateral ventricle (HP:0030047)	3.76191504
10	Keratoconjunctivitis (HP:0001096)	3.56736617
11	Keratoconjunctivitis sicca (HP:0001097)	3.38691786
12	Poor suck (HP:0002033)	2.96715627
13	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.86864851
14	Generalized aminoaciduria (HP:0002909)	2.85079993
15	Glycosuria (HP:0003076)	2.84331012
16	Abnormality of urine glucose concentration (HP:0011016)	2.84331012
17	Tubular atrophy (HP:0000092)	2.76290620
18	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.72100697
19	Congenital sensorineural hearing impairment (HP:0008527)	2.70952243
20	Proximal tubulopathy (HP:0000114)	2.68772604
21	Hematochezia (HP:0002573)	2.66059452
22	Amelogenesis imperfecta (HP:0000705)	2.65395904
23	Pendular nystagmus (HP:0012043)	2.62279262
24	True hermaphroditism (HP:0010459)	2.61377791
25	Steatorrhea (HP:0002570)	2.59584378
26	Testicular neoplasm (HP:0010788)	2.52081541
27	Mesangial abnormality (HP:0001966)	2.50747845
28	Hyperkalemia (HP:0002153)	2.48916649
29	Anteriorly placed anus (HP:0001545)	2.47539405
30	Progressive macrocephaly (HP:0004481)	2.43683188
31	Abnormal albumin level (HP:0012116)	2.38551729
32	Hypoalbuminemia (HP:0003073)	2.38551729
33	Facial shape deformation (HP:0011334)	2.37870441
34	Potter facies (HP:0002009)	2.37870441
35	Abnormality of vitamin B metabolism (HP:0004340)	2.37122211
36	Hypokinesia (HP:0002375)	2.33351396
37	Male pseudohermaphroditism (HP:0000037)	2.33312265
38	Sex reversal (HP:0012245)	2.32211133
39	Abnormal sex determination (HP:0012244)	2.32211133
40	Double outlet right ventricle (HP:0001719)	2.31510053
41	Congenital malformation of the right heart (HP:0011723)	2.31510053
42	Hypoproteinemia (HP:0003075)	2.29846344
43	Neonatal respiratory distress (HP:0002643)	2.29805216
44	Abnormality of fatty-acid metabolism (HP:0004359)	2.27610438
45	Keratitis (HP:0000491)	2.27055308
46	Choroideremia (HP:0001139)	2.24057923
47	Popliteal pterygium (HP:0009756)	2.23486610
48	Azoospermia (HP:0000027)	2.21868770
49	Horizontal nystagmus (HP:0000666)	2.19826308
50	Abnormality of chloride homeostasis (HP:0011422)	2.19326180
51	Hyperglycemia (HP:0003074)	2.18287841
52	Gout (HP:0001997)	2.16734746
53	Exocrine pancreatic insufficiency (HP:0001738)	2.14860112
54	Fat malabsorption (HP:0002630)	2.13858749
55	Abnormality of vitamin metabolism (HP:0100508)	2.13855459
56	Agitation (HP:0000713)	2.09869650
57	Overriding aorta (HP:0002623)	2.08847463
58	Unilateral renal agenesis (HP:0000122)	2.08144094
59	Intestinal atresia (HP:0011100)	2.04591139
60	Pancreatic fibrosis (HP:0100732)	2.04387728
61	Buphthalmos (HP:0000557)	2.04106949
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03547633
63	Absent/shortened dynein arms (HP:0200106)	2.03547633
64	Asymmetry of the thorax (HP:0001555)	2.02431085
65	Lymphangioma (HP:0100764)	2.02059214
66	Vascular calcification (HP:0004934)	2.01543094
67	Sclerocornea (HP:0000647)	2.01147313
68	Ketoacidosis (HP:0001993)	2.00930633
69	Pancreatic cysts (HP:0001737)	2.00038098
70	Hypobetalipoproteinemia (HP:0003563)	1.99141962
71	Abnormality of the line of Schwalbe (HP:0008048)	1.97287632
72	Congenital stationary night blindness (HP:0007642)	1.96355231
73	Abnormality of dental color (HP:0011073)	1.95010751
74	Decreased circulating renin level (HP:0003351)	1.93549977
75	Late onset (HP:0003584)	1.92717424
76	Conjunctival hamartoma (HP:0100780)	1.92222504
77	Diminished movement (HP:0002374)	1.89082868
78	Hyperphosphatemia (HP:0002905)	1.89064076
79	Hemiparesis (HP:0001269)	1.88730629
80	Furrowed tongue (HP:0000221)	1.87510818
81	Malnutrition (HP:0004395)	1.86937450
82	Myopathic facies (HP:0002058)	1.86553708
83	Ketosis (HP:0001946)	1.86509037
84	Tinnitus (HP:0000360)	1.84105748
85	Insulin-resistant diabetes mellitus (HP:0000831)	1.83250823
86	Increased CSF protein (HP:0002922)	1.80775138
87	Nephronophthisis (HP:0000090)	1.78882983
88	Delayed gross motor development (HP:0002194)	1.78681171
89	Muscle fiber inclusion bodies (HP:0100299)	1.78672180
90	Neoplasm of the adrenal cortex (HP:0100641)	1.78595357
91	Abnormality of the renal cortex (HP:0011035)	1.78228622
92	Acute necrotizing encephalopathy (HP:0006965)	1.77873768
93	Bronchiectasis (HP:0002110)	1.76230087
94	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.74274899
95	Dysautonomia (HP:0002459)	1.73317021
96	Hyperactive renin-angiotensin system (HP:0000841)	1.73075389
97	Amblyopia (HP:0000646)	1.72983806
98	Abnormal respiratory epithelium morphology (HP:0012253)	1.71261256
99	Abnormal respiratory motile cilium morphology (HP:0005938)	1.71261256
100	Palpitations (HP:0001962)	1.71137473

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.16599109
2	MST4	5.96110238
3	PRKD3	5.76397507
4	TEC	4.97675570
5	MAP4K2	4.68756745
6	ITK	4.06269476
7	FGFR2	3.51458193
8	PKN2	3.15809214
9	PTK2	2.77920922
10	BTK	2.12565127
11	MKNK1	1.99911008
12	TRPM7	1.97345402
13	ERBB3	1.87133082
14	RPS6KB2	1.54381397
15	MAP2K6	1.43315956
16	FLT3	1.41057231
17	PHKG2	1.36671583
18	PHKG1	1.36671583
19	FGFR3	1.35462618
20	MAPKAPK5	1.30010865
21	MKNK2	1.19926525
22	OBSCN	1.18334314
23	EPHA2	1.15174307
24	PRKCI	1.12366729
25	PAK3	1.02653495
26	LRRK2	1.02481922
27	TAOK1	1.01377318
28	MST1R	0.98088065
29	STK4	0.97355549
30	GRK1	0.95277755
31	NTRK3	0.91918963
32	STK3	0.89407116
33	STK10	0.85406110
34	FER	0.84357397
35	STK39	0.77417880
36	PRKCE	0.68414369
37	IRAK3	0.66702816
38	BMPR1B	0.66410745
39	MAP2K1	0.64399400
40	LMTK2	0.61744553
41	MAPKAPK3	0.61693062
42	WNK3	0.61671563
43	AKT3	0.58347649
44	OXSR1	0.57161336
45	EIF2AK1	0.56018412
46	CASK	0.55179879
47	UHMK1	0.54678014
48	PAK4	0.54616446
49	DYRK2	0.50182131
50	MAP2K2	0.49408310
51	TNK2	0.49174896
52	ADRBK2	0.48977737
53	INSRR	0.45549839
54	STK11	0.43101787
55	PRKD2	0.42758703
56	STK16	0.41391683
57	IRAK2	0.41076514
58	CSNK1G3	0.40230169
59	EEF2K	0.39884376
60	TRIB3	0.38181676
61	AKT2	0.37932889
62	MAP3K7	0.36710209
63	PINK1	0.34086824
64	HIPK2	0.33714120
65	LIMK1	0.33139091
66	CSNK1G1	0.31704771
67	DAPK2	0.30585432
68	PRKG2	0.30314224
69	BRSK1	0.30009897
70	IRAK4	0.29037299
71	WNK4	0.28408415
72	MET	0.26558817
73	MAP3K2	0.25000046
74	ROCK1	0.24852961
75	DYRK1B	0.23291445
76	PRKACA	0.23033882
77	IGF1R	0.22593386
78	CAMK2D	0.21877899
79	PRKAA1	0.19986801
80	SRC	0.18798615
81	CSNK1G2	0.18734573
82	PRKAA2	0.18523031
83	AURKA	0.16992795
84	YES1	0.16603402
85	CSNK1A1	0.16576171
86	MAPK11	0.16195016
87	NME1	0.16040173
88	TESK1	0.15659709
89	MARK2	0.14842957
90	NLK	0.14725004
91	RPS6KA5	0.14443284
92	DYRK3	0.14265666
93	EGFR	0.14023565
94	PRKCZ	0.13969679
95	BCKDK	0.13187915
96	INSR	0.12712436
97	TBK1	0.12040229
98	PLK1	0.11933559
99	PRKACB	0.11655663
100	TTK	0.11003680

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taste transduction_Homo sapiens_hsa04742	5.06304370
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.19496219
3	Renin-angiotensin system_Homo sapiens_hsa04614	2.69082412
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.56953195
5	Pancreatic secretion_Homo sapiens_hsa04972	2.37784487
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10097088
7	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.04418309
8	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.00528553
9	Sulfur metabolism_Homo sapiens_hsa00920	2.00467561
10	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.96598402
11	Phototransduction_Homo sapiens_hsa04744	1.87387829
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.87077529
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.75784800
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75769269
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.72621759
16	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.67677769
17	Other glycan degradation_Homo sapiens_hsa00511	1.65059258
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.64803517
19	Fat digestion and absorption_Homo sapiens_hsa04975	1.64478263
20	Folate biosynthesis_Homo sapiens_hsa00790	1.62448511
21	Serotonergic synapse_Homo sapiens_hsa04726	1.59079474
22	Propanoate metabolism_Homo sapiens_hsa00640	1.58030004
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.48724168
24	Insulin secretion_Homo sapiens_hsa04911	1.46849912
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.41718485
26	Vibrio cholerae infection_Homo sapiens_hsa05110	1.37148629
27	Parkinsons disease_Homo sapiens_hsa05012	1.35903797
28	Protein digestion and absorption_Homo sapiens_hsa04974	1.32261073
29	Peroxisome_Homo sapiens_hsa04146	1.31589578
30	Caffeine metabolism_Homo sapiens_hsa00232	1.31504511
31	Retinol metabolism_Homo sapiens_hsa00830	1.29867743
32	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.28882626
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.28556564
34	Renin secretion_Homo sapiens_hsa04924	1.26376828
35	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.25882288
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.25296537
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.24159707
38	Butanoate metabolism_Homo sapiens_hsa00650	1.23656536
39	Sphingolipid metabolism_Homo sapiens_hsa00600	1.23624516
40	Glutathione metabolism_Homo sapiens_hsa00480	1.21087585
41	Chemical carcinogenesis_Homo sapiens_hsa05204	1.19650708
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.18774820
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.12496653
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.10760785
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.09216410
46	Alzheimers disease_Homo sapiens_hsa05010	1.06429738
47	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.02015226
48	Glucagon signaling pathway_Homo sapiens_hsa04922	1.01101335
49	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99665388
50	Arginine biosynthesis_Homo sapiens_hsa00220	0.93652824
51	Arginine and proline metabolism_Homo sapiens_hsa00330	0.89964126
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.89180465
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.88711631
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88045908
55	Calcium signaling pathway_Homo sapiens_hsa04020	0.85065224
56	ABC transporters_Homo sapiens_hsa02010	0.82559081
57	Sulfur relay system_Homo sapiens_hsa04122	0.79922473
58	Huntingtons disease_Homo sapiens_hsa05016	0.78973251
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.78216096
60	Protein export_Homo sapiens_hsa03060	0.77734747
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.75847223
62	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.75653087
63	Mineral absorption_Homo sapiens_hsa04978	0.74804301
64	Salivary secretion_Homo sapiens_hsa04970	0.72482069
65	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.72264164
66	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70970225
67	Circadian rhythm_Homo sapiens_hsa04710	0.70833691
68	Metabolic pathways_Homo sapiens_hsa01100	0.70457814
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68089209
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67997816
71	Morphine addiction_Homo sapiens_hsa05032	0.67739233
72	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.67215285
73	Tyrosine metabolism_Homo sapiens_hsa00350	0.65792879
74	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.63314437
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63193939
76	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.61882465
77	Gastric acid secretion_Homo sapiens_hsa04971	0.61679985
78	Tight junction_Homo sapiens_hsa04530	0.60467337
79	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59993721
80	Cholinergic synapse_Homo sapiens_hsa04725	0.58894815
81	Fatty acid degradation_Homo sapiens_hsa00071	0.58557514
82	Histidine metabolism_Homo sapiens_hsa00340	0.55630669
83	Bile secretion_Homo sapiens_hsa04976	0.55251206
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.53422027
85	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.53093578
86	Phenylalanine metabolism_Homo sapiens_hsa00360	0.51209176
87	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48023095
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.45193066
89	Galactose metabolism_Homo sapiens_hsa00052	0.44863810
90	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.43936498
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.43326599
92	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.42377582
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.41857019
94	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.41777282
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.39419917
96	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.39276985
97	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37694350
98	GABAergic synapse_Homo sapiens_hsa04727	0.36657024
99	Circadian entrainment_Homo sapiens_hsa04713	0.36154616
100	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.34215581

C11ORF53

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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