ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA double-strand break processing (GO:0000729)	3.80914150
2	behavioral response to nicotine (GO:0035095)	3.75413794
3	neural tube formation (GO:0001841)	3.31620819
4	regulation of DNA endoreduplication (GO:0032875)	3.27501423
5	response to pheromone (GO:0019236)	3.22874499
6	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.20395351
7	ribosomal large subunit biogenesis (GO:0042273)	3.18508504
8	signal peptide processing (GO:0006465)	3.14271876
9	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.12048911
10	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.11771762
11	DNA replication checkpoint (GO:0000076)	3.08850793
12	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.98067213
13	protein prenylation (GO:0018342)	2.96348848
14	prenylation (GO:0097354)	2.96348848
15	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.96296527
16	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.96296527
17	water-soluble vitamin biosynthetic process (GO:0042364)	2.94439174
18	regulation of centriole replication (GO:0046599)	2.91411993
19	pyrimidine nucleobase catabolic process (GO:0006208)	2.87964121
20	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.86273555
21	regulation of mitotic spindle checkpoint (GO:1903504)	2.86273555
22	chromatin remodeling at centromere (GO:0031055)	2.84244240
23	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.83244644
24	maturation of 5.8S rRNA (GO:0000460)	2.81904714
25	meiotic chromosome segregation (GO:0045132)	2.81718161
26	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.77982616
27	CENP-A containing nucleosome assembly (GO:0034080)	2.76301922
28	DNA catabolic process, exonucleolytic (GO:0000738)	2.70578715
29	presynaptic membrane assembly (GO:0097105)	2.68346773
30	L-fucose catabolic process (GO:0042355)	2.67377390
31	fucose catabolic process (GO:0019317)	2.67377390
32	L-fucose metabolic process (GO:0042354)	2.67377390
33	replication fork processing (GO:0031297)	2.67068891
34	piRNA metabolic process (GO:0034587)	2.66462724
35	reciprocal DNA recombination (GO:0035825)	2.64573479
36	reciprocal meiotic recombination (GO:0007131)	2.64573479
37	organelle disassembly (GO:1903008)	2.62672347
38	translational termination (GO:0006415)	2.62497322
39	DNA replication-dependent nucleosome organization (GO:0034723)	2.61758970
40	DNA replication-dependent nucleosome assembly (GO:0006335)	2.61758970
41	synapsis (GO:0007129)	2.61238195
42	protein-cofactor linkage (GO:0018065)	2.60149066
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.58081953
44	regulation of centrosome cycle (GO:0046605)	2.57322681
45	protein K6-linked ubiquitination (GO:0085020)	2.57159937
46	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.56921654
47	ribosomal small subunit assembly (GO:0000028)	2.56331481
48	ribonucleoprotein complex disassembly (GO:0032988)	2.54032310
49	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.51715344
50	ATP synthesis coupled proton transport (GO:0015986)	2.51715344
51	resolution of meiotic recombination intermediates (GO:0000712)	2.51222576
52	histone exchange (GO:0043486)	2.49949739
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.48733509
54	NADH dehydrogenase complex assembly (GO:0010257)	2.48733509
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.48733509
56	centriole replication (GO:0007099)	2.47185564
57	protein complex biogenesis (GO:0070271)	2.46833382
58	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.45081171
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.45081171
60	regulation of centrosome duplication (GO:0010824)	2.44847538
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.44485445
62	respiratory chain complex IV assembly (GO:0008535)	2.43176762
63	viral transcription (GO:0019083)	2.41538785
64	postreplication repair (GO:0006301)	2.41301651
65	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.41255745
66	isotype switching (GO:0045190)	2.41255745
67	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.41255745
68	recombinational repair (GO:0000725)	2.40888362
69	postsynaptic membrane organization (GO:0001941)	2.40475120
70	double-strand break repair via homologous recombination (GO:0000724)	2.39270726
71	monoubiquitinated protein deubiquitination (GO:0035520)	2.38309509
72	positive regulation of histone H3-K4 methylation (GO:0051571)	2.37856572
73	presynaptic membrane organization (GO:0097090)	2.36353550
74	nonmotile primary cilium assembly (GO:0035058)	2.35465121
75	ncRNA catabolic process (GO:0034661)	2.34855661
76	translational initiation (GO:0006413)	2.33057359
77	replicative senescence (GO:0090399)	2.33040951
78	nucleobase catabolic process (GO:0046113)	2.32670974
79	rRNA catabolic process (GO:0016075)	2.32610799
80	ribonucleoprotein complex biogenesis (GO:0022613)	2.32375908
81	pseudouridine synthesis (GO:0001522)	2.32355628
82	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.31199547
83	cellular component biogenesis (GO:0044085)	2.29810814
84	spermatid nucleus differentiation (GO:0007289)	2.29466502
85	L-methionine salvage (GO:0071267)	2.28802890
86	L-methionine biosynthetic process (GO:0071265)	2.28802890
87	amino acid salvage (GO:0043102)	2.28802890
88	cotranslational protein targeting to membrane (GO:0006613)	2.28784738
89	establishment of mitochondrion localization (GO:0051654)	2.28104449
90	mitochondrion transport along microtubule (GO:0047497)	2.27260985
91	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.27260985
92	kinetochore organization (GO:0051383)	2.26435074
93	DNA damage response, detection of DNA damage (GO:0042769)	2.26431178
94	kidney morphogenesis (GO:0060993)	2.25372614
95	centrosome organization (GO:0051297)	2.25196960
96	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.25148470
97	positive regulation of mRNA processing (GO:0050685)	2.24729687
98	somatic diversification of immunoglobulins (GO:0016445)	2.24463832
99	microtubule organizing center organization (GO:0031023)	2.24445421
100	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.24043020

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99269795
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.95956770
3	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.92442381
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.85780196
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.67297266
6	EWS_26573619_Chip-Seq_HEK293_Human	2.62669262
7	FUS_26573619_Chip-Seq_HEK293_Human	2.61981996
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.58918104
9	VDR_22108803_ChIP-Seq_LS180_Human	2.57798912
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.55530939
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.53264938
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48623296
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44248073
14	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40781850
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.40225551
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.34887310
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30417425
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.30180423
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26925398
20	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25862316
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.21713551
22	E2F7_22180533_ChIP-Seq_HELA_Human	2.06080710
23	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.99791603
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99175235
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.90827947
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.89121355
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88939569
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.83740248
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79249590
30	* VDR_23849224_ChIP-Seq_CD4+_Human	1.77591981
31	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.72444248
32	P300_19829295_ChIP-Seq_ESCs_Human	1.70137891
33	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.68448503
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64618224
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.61191996
36	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.59364996
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.58748684
38	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58716800
39	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.56658562
40	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54716454
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.54162176
42	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.52711715
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51060613
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.50965473
45	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.50394869
46	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50350830
47	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47306132
48	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.43477883
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.43067204
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.42770608
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40755434
52	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.39859110
53	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.38406480
54	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.37818550
55	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.36862591
56	* FOXP3_21729870_ChIP-Seq_TREG_Human	1.36048148
57	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.32301265
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30883020
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30624297
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.30624297
61	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.29235079
62	TTF2_22483619_ChIP-Seq_HELA_Human	1.24555498
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24457331
64	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.24269557
65	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.24238200
66	TP53_22573176_ChIP-Seq_HFKS_Human	1.22455355
67	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21527557
68	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.19859483
69	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.18304331
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17823362
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.14769515
72	STAT3_23295773_ChIP-Seq_U87_Human	1.11810751
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09919868
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09709992
75	TCF4_23295773_ChIP-Seq_U87_Human	1.09398594
76	AR_25329375_ChIP-Seq_VCAP_Human	1.07176330
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06542971
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05805748
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05465320
80	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04921886
81	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03774232
82	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.03558397
83	REST_21632747_ChIP-Seq_MESCs_Mouse	1.03205314
84	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.02863767
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00073711
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00073711
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.99711729
88	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96721754
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.96689334
90	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.95953098
91	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95743991
92	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.95185696
93	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.94889137
94	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.94656779
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.94429091
96	SOX2_19829295_ChIP-Seq_ESCs_Human	0.94429091
97	JUN_21703547_ChIP-Seq_K562_Human	0.94402767
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.90119336
99	GABP_19822575_ChIP-Seq_HepG2_Human	0.89336692
100	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.89283791

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	2.78281385
2	MP0008057_abnormal_DNA_replication	2.62639726
3	MP0008877_abnormal_DNA_methylation	2.51769129
4	MP0006292_abnormal_olfactory_placode	2.47062953
5	MP0009379_abnormal_foot_pigmentation	2.36382753
6	MP0003890_abnormal_embryonic-extraembry	2.23631497
7	MP0003880_abnormal_central_pattern	2.17701434
8	MP0003787_abnormal_imprinting	2.10015296
9	MP0003693_abnormal_embryo_hatching	2.08340789
10	MP0010094_abnormal_chromosome_stability	2.04883995
11	MP0006072_abnormal_retinal_apoptosis	1.91577428
12	MP0000569_abnormal_digit_pigmentation	1.86810483
13	MP0003646_muscle_fatigue	1.86492552
14	MP0004145_abnormal_muscle_electrophysio	1.83178971
15	MP0003121_genomic_imprinting	1.80244294
16	MP0000778_abnormal_nervous_system	1.72616988
17	MP0002102_abnormal_ear_morphology	1.71060523
18	MP0009046_muscle_twitch	1.66256226
19	MP0005187_abnormal_penis_morphology	1.65034358
20	MP0002638_abnormal_pupillary_reflex	1.62775291
21	MP0000631_abnormal_neuroendocrine_gland	1.61024431
22	MP0005646_abnormal_pituitary_gland	1.60401299
23	MP0003718_maternal_effect	1.53900836
24	MP0003136_yellow_coat_color	1.52768076
25	MP0002837_dystrophic_cardiac_calcinosis	1.51099108
26	MP0008995_early_reproductive_senescence	1.48867263
27	MP0001188_hyperpigmentation	1.47478483
28	MP0004147_increased_porphyrin_level	1.45801523
29	MP0005551_abnormal_eye_electrophysiolog	1.45132913
30	MP0002160_abnormal_reproductive_system	1.43518932
31	MP0002736_abnormal_nociception_after	1.42290518
32	MP0001529_abnormal_vocalization	1.41613886
33	MP0002938_white_spotting	1.40259135
34	MP0006276_abnormal_autonomic_nervous	1.37463918
35	MP0002272_abnormal_nervous_system	1.35355055
36	MP0004142_abnormal_muscle_tone	1.35263585
37	MP0005253_abnormal_eye_physiology	1.34469782
38	MP0002234_abnormal_pharynx_morphology	1.33196372
39	MP0001968_abnormal_touch/_nociception	1.32607055
40	MP0003937_abnormal_limbs/digits/tail_de	1.32143090
41	MP0005645_abnormal_hypothalamus_physiol	1.31213848
42	MP0003315_abnormal_perineum_morphology	1.30806831
43	MP0003567_abnormal_fetal_cardiomyocyte	1.28942887
44	MP0004957_abnormal_blastocyst_morpholog	1.24722504
45	MP0003119_abnormal_digestive_system	1.23034584
46	MP0002163_abnormal_gland_morphology	1.22642699
47	MP0001293_anophthalmia	1.20935565
48	MP0005423_abnormal_somatic_nervous	1.20861244
49	MP0009697_abnormal_copulation	1.19186448
50	MP0004133_heterotaxia	1.18522998
51	MP0002210_abnormal_sex_determination	1.16790204
52	MP0002751_abnormal_autonomic_nervous	1.16499838
53	MP0003077_abnormal_cell_cycle	1.16075571
54	MP0002557_abnormal_social/conspecific_i	1.15681411
55	MP0002928_abnormal_bile_duct	1.15233645
56	MP0005389_reproductive_system_phenotype	1.15190103
57	MP0003111_abnormal_nucleus_morphology	1.14620508
58	MP0008007_abnormal_cellular_replicative	1.14118319
59	MP0000427_abnormal_hair_cycle	1.10043543
60	MP0000955_abnormal_spinal_cord	1.08809079
61	MP0002095_abnormal_skin_pigmentation	1.08444334
62	MP0003283_abnormal_digestive_organ	1.07985235
63	MP0004924_abnormal_behavior	1.07751484
64	MP0005386_behavior/neurological_phenoty	1.07751484
65	MP0003123_paternal_imprinting	1.06261816
66	MP0005084_abnormal_gallbladder_morpholo	1.06170615
67	MP0001286_abnormal_eye_development	1.06129752
68	MP0001929_abnormal_gametogenesis	1.05766666
69	MP0005379_endocrine/exocrine_gland_phen	1.05750585
70	MP0001919_abnormal_reproductive_system	1.05067626
71	MP0003122_maternal_imprinting	1.04964405
72	MP0003635_abnormal_synaptic_transmissio	1.04204622
73	MP0004742_abnormal_vestibular_system	1.03349717
74	MP0004885_abnormal_endolymph	1.02922955
75	MP0002184_abnormal_innervation	1.00396071
76	MP0003786_premature_aging	0.99451351
77	MP0001984_abnormal_olfaction	0.99426919
78	MP0006035_abnormal_mitochondrial_morpho	0.98387252
79	MP0005195_abnormal_posterior_eye	0.98251675
80	MP0003861_abnormal_nervous_system	0.98153660
81	MP0008789_abnormal_olfactory_epithelium	0.97395379
82	MP0009745_abnormal_behavioral_response	0.97297778
83	MP0002067_abnormal_sensory_capabilities	0.96847938
84	MP0008932_abnormal_embryonic_tissue	0.95411264
85	MP0000647_abnormal_sebaceous_gland	0.94466310
86	MP0003195_calcinosis	0.94344174
87	MP0003698_abnormal_male_reproductive	0.93391061
88	MP0001145_abnormal_male_reproductive	0.91352793
89	MP0005174_abnormal_tail_pigmentation	0.90927364
90	MP0002084_abnormal_developmental_patter	0.90357457
91	MP0002572_abnormal_emotion/affect_behav	0.90330033
92	MP0000653_abnormal_sex_gland	0.89605934
93	MP0008872_abnormal_physiological_respon	0.87895522
94	MP0002653_abnormal_ependyma_morphology	0.87651524
95	MP0002752_abnormal_somatic_nervous	0.86763025
96	MP0002063_abnormal_learning/memory/cond	0.85791105
97	MP0002152_abnormal_brain_morphology	0.84206504
98	MP0000049_abnormal_middle_ear	0.83506102
99	MP0002882_abnormal_neuron_morphology	0.83482420
100	MP0002009_preneoplasia	0.83429009

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased hepatocellular lipid droplets (HP:0006565)	3.22171405
2	Type II lissencephaly (HP:0007260)	3.12932699
3	Lipid accumulation in hepatocytes (HP:0006561)	3.08218738
4	Pendular nystagmus (HP:0012043)	3.05748388
5	Pancreatic cysts (HP:0001737)	3.05193329
6	Nephronophthisis (HP:0000090)	2.95067618
7	Cerebellar dysplasia (HP:0007033)	2.85503613
8	Medial flaring of the eyebrow (HP:0010747)	2.80333941
9	Molar tooth sign on MRI (HP:0002419)	2.74815978
10	Abnormality of midbrain morphology (HP:0002418)	2.74815978
11	Birth length less than 3rd percentile (HP:0003561)	2.72964866
12	Pancreatic fibrosis (HP:0100732)	2.70901807
13	Drooling (HP:0002307)	2.64671570
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.58795285
15	True hermaphroditism (HP:0010459)	2.56433079
16	Lissencephaly (HP:0001339)	2.53892883
17	Abnormality of the renal medulla (HP:0100957)	2.46841723
18	Acute necrotizing encephalopathy (HP:0006965)	2.45583472
19	Abnormality of alanine metabolism (HP:0010916)	2.44650451
20	Hyperalaninemia (HP:0003348)	2.44650451
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.44650451
22	Abnormality of the pons (HP:0007361)	2.42228872
23	Volvulus (HP:0002580)	2.33859857
24	Excessive salivation (HP:0003781)	2.32999083
25	Hypoplasia of the pons (HP:0012110)	2.31801921
26	Supernumerary spleens (HP:0009799)	2.30661365
27	Broad-based gait (HP:0002136)	2.29912235
28	Progressive macrocephaly (HP:0004481)	2.26093604
29	Mitochondrial inheritance (HP:0001427)	2.25579932
30	Patellar aplasia (HP:0006443)	2.21728336
31	Increased CSF lactate (HP:0002490)	2.21555275
32	Gait imbalance (HP:0002141)	2.20940588
33	Chronic hepatic failure (HP:0100626)	2.20373215
34	Attenuation of retinal blood vessels (HP:0007843)	2.19561843
35	Acute encephalopathy (HP:0006846)	2.16882882
36	Abnormality of cells of the erythroid lineage (HP:0012130)	2.13715017
37	Congenital primary aphakia (HP:0007707)	2.09841375
38	Decreased central vision (HP:0007663)	2.09560740
39	Methylmalonic acidemia (HP:0002912)	2.07978290
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.04929507
41	Aplasia/Hypoplasia of the patella (HP:0006498)	2.01307204
42	Congenital stationary night blindness (HP:0007642)	2.00979446
43	Partial agenesis of the corpus callosum (HP:0001338)	2.00076737
44	Abnormality of the renal cortex (HP:0011035)	1.99457204
45	Dyskinesia (HP:0100660)	1.96654118
46	Abnormal mitochondria in muscle tissue (HP:0008316)	1.95820851
47	Gaze-evoked nystagmus (HP:0000640)	1.94499317
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.94402631
49	3-Methylglutaconic aciduria (HP:0003535)	1.93799512
50	Renal Fanconi syndrome (HP:0001994)	1.93664661
51	Retinal dysplasia (HP:0007973)	1.91519746
52	Nephrogenic diabetes insipidus (HP:0009806)	1.91342560
53	Abnormal number of erythroid precursors (HP:0012131)	1.91201869
54	Absent/shortened dynein arms (HP:0200106)	1.89827969
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.89827969
56	Abnormality of the labia minora (HP:0012880)	1.89566206
57	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85835628
58	Neuroendocrine neoplasm (HP:0100634)	1.85080000
59	Neoplasm of the adrenal cortex (HP:0100641)	1.83805509
60	Intestinal atresia (HP:0011100)	1.82241394
61	Sclerocornea (HP:0000647)	1.81236873
62	Oligodactyly (hands) (HP:0001180)	1.80534218
63	Agitation (HP:0000713)	1.79117227
64	Anencephaly (HP:0002323)	1.77443923
65	Hyperglycinemia (HP:0002154)	1.76243484
66	Optic disc pallor (HP:0000543)	1.76114649
67	Genital tract atresia (HP:0001827)	1.75648392
68	Pachygyria (HP:0001302)	1.74810420
69	Abnormality of chromosome stability (HP:0003220)	1.73761106
70	CNS hypomyelination (HP:0003429)	1.72736107
71	Limb hypertonia (HP:0002509)	1.72379787
72	Vaginal atresia (HP:0000148)	1.72179429
73	Febrile seizures (HP:0002373)	1.69998758
74	Increased corneal curvature (HP:0100692)	1.69395579
75	Keratoconus (HP:0000563)	1.69395579
76	Sloping forehead (HP:0000340)	1.69021609
77	Protruding tongue (HP:0010808)	1.68494235
78	Dandy-Walker malformation (HP:0001305)	1.67583304
79	Poor coordination (HP:0002370)	1.67238677
80	Abolished electroretinogram (ERG) (HP:0000550)	1.66577373
81	Colon cancer (HP:0003003)	1.65712901
82	Hepatocellular necrosis (HP:0001404)	1.64802376
83	Renal cortical cysts (HP:0000803)	1.63432439
84	Abnormality of the carotid arteries (HP:0005344)	1.63162431
85	Increased serum lactate (HP:0002151)	1.62906498
86	Meckel diverticulum (HP:0002245)	1.62227421
87	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.61990423
88	Short tibia (HP:0005736)	1.60476612
89	Abnormal biliary tract physiology (HP:0012439)	1.59904229
90	Bile duct proliferation (HP:0001408)	1.59904229
91	Genetic anticipation (HP:0003743)	1.59170661
92	Abnormality of the ileum (HP:0001549)	1.58528850
93	Chromsome breakage (HP:0040012)	1.57768077
94	Preaxial hand polydactyly (HP:0001177)	1.57631505
95	Cerebral edema (HP:0002181)	1.56598147
96	Hyperventilation (HP:0002883)	1.56370587
97	Optic nerve hypoplasia (HP:0000609)	1.55158711
98	Small hand (HP:0200055)	1.54963718
99	Congenital, generalized hypertrichosis (HP:0004540)	1.54730692
100	Asplenia (HP:0001746)	1.54333133

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	3.41287884
2	FRK	3.29214949
3	ZAK	2.95707072
4	MAP3K4	2.83205960
5	BMPR1B	2.81238343
6	MKNK2	2.66881011
7	CASK	2.60139529
8	PNCK	2.11129648
9	STK16	2.11018618
10	MKNK1	2.03746102
11	CDC7	1.99348781
12	EIF2AK3	1.97823255
13	MAP2K7	1.92016877
14	SRPK1	1.85171124
15	WNK3	1.76874195
16	PLK4	1.75507085
17	MARK1	1.74108272
18	ACVR1B	1.69303289
19	WEE1	1.67591799
20	BRSK2	1.63853970
21	TSSK6	1.57844299
22	PLK3	1.57402534
23	NUAK1	1.53324389
24	EIF2AK1	1.49134842
25	MAP4K2	1.48683849
26	TLK1	1.44125229
27	PLK2	1.39821461
28	ERBB3	1.36561858
29	TGFBR1	1.36131809
30	VRK1	1.33213521
31	TRIM28	1.32459443
32	CAMKK2	1.31484356
33	WNK4	1.26754984
34	MAPK13	1.23069081
35	STK38L	1.18526345
36	GRK1	1.12323345
37	DYRK2	1.10321682
38	ADRBK2	1.10237280
39	CAMK1D	1.08244374
40	STK3	1.07665870
41	DYRK3	1.05774639
42	PLK1	1.00774008
43	CAMK1G	0.99331142
44	BRD4	0.96297279
45	CSNK1G2	0.93503588
46	NEK2	0.92525996
47	PRKCG	0.90354398
48	MAP2K4	0.88954440
49	ATR	0.87443726
50	TTK	0.85922373
51	BUB1	0.85728865
52	INSRR	0.85430685
53	BCR	0.83574222
54	RPS6KA4	0.82778051
55	CHEK2	0.77989532
56	PBK	0.74902454
57	ATM	0.74651316
58	NEK1	0.74070249
59	PINK1	0.73455252
60	EIF2AK2	0.71259170
61	CSNK1G1	0.70622987
62	CSNK1E	0.70264712
63	PASK	0.68553382
64	RPS6KA5	0.65670680
65	CDK3	0.64751281
66	CSNK1G3	0.64018187
67	NTRK3	0.62067253
68	STK39	0.59498782
69	PRKCE	0.58171610
70	TAOK3	0.56789764
71	CDK8	0.55972952
72	PAK3	0.55922775
73	MAPKAPK5	0.53963952
74	CHEK1	0.53403223
75	TAF1	0.51998964
76	OBSCN	0.50355170
77	EPHA4	0.49456220
78	PKN1	0.48959042
79	AURKB	0.48433458
80	NTRK2	0.47300430
81	MINK1	0.46777948
82	CSNK1A1L	0.46424814
83	PHKG2	0.43586481
84	PHKG1	0.43586481
85	CSNK2A2	0.43369560
86	CCNB1	0.43105662
87	RPS6KB2	0.42518911
88	CSNK1D	0.42173511
89	OXSR1	0.41919089
90	CDK1	0.41846971
91	STK24	0.41279333
92	MAPK15	0.40349374
93	PRKDC	0.40161243
94	CAMK2A	0.37637092
95	PIM1	0.37590427
96	CDK2	0.36928765
97	CSNK2A1	0.35376649
98	PRKCI	0.34360738
99	TEC	0.34081922
100	AURKA	0.33829551

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.05391389
2	Protein export_Homo sapiens_hsa03060	2.88597650
3	Basal transcription factors_Homo sapiens_hsa03022	2.69359890
4	RNA degradation_Homo sapiens_hsa03018	2.60082702
5	Non-homologous end-joining_Homo sapiens_hsa03450	2.51825579
6	RNA polymerase_Homo sapiens_hsa03020	2.51642863
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.49818009
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.45352602
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44059469
10	Homologous recombination_Homo sapiens_hsa03440	2.43114165
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.36034912
12	Oxidative phosphorylation_Homo sapiens_hsa00190	2.28151142
13	Nicotine addiction_Homo sapiens_hsa05033	2.25174155
14	RNA transport_Homo sapiens_hsa03013	2.14229868
15	Parkinsons disease_Homo sapiens_hsa05012	2.02138412
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.92833584
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83289131
18	One carbon pool by folate_Homo sapiens_hsa00670	1.81576493
19	Propanoate metabolism_Homo sapiens_hsa00640	1.69231822
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.68236329
21	Nucleotide excision repair_Homo sapiens_hsa03420	1.61043362
22	Spliceosome_Homo sapiens_hsa03040	1.59163172
23	Mismatch repair_Homo sapiens_hsa03430	1.57556517
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.55127352
25	Huntingtons disease_Homo sapiens_hsa05016	1.52251036
26	Phototransduction_Homo sapiens_hsa04744	1.50974596
27	Butanoate metabolism_Homo sapiens_hsa00650	1.50659233
28	mRNA surveillance pathway_Homo sapiens_hsa03015	1.48363637
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.44905805
30	DNA replication_Homo sapiens_hsa03030	1.44760790
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.34536434
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.31627113
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30288088
34	Alzheimers disease_Homo sapiens_hsa05010	1.26165689
35	Cell cycle_Homo sapiens_hsa04110	1.22969545
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.19159939
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.14407836
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.11665765
39	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.10648718
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.10367038
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08239635
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.07887315
43	Taste transduction_Homo sapiens_hsa04742	1.07401887
44	Proteasome_Homo sapiens_hsa03050	1.05565811
45	Base excision repair_Homo sapiens_hsa03410	1.05417376
46	Purine metabolism_Homo sapiens_hsa00230	0.97856927
47	Olfactory transduction_Homo sapiens_hsa04740	0.97595382
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.96634842
49	Sulfur relay system_Homo sapiens_hsa04122	0.90870585
50	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.86977605
51	Peroxisome_Homo sapiens_hsa04146	0.85626527
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.84982024
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.84532865
54	p53 signaling pathway_Homo sapiens_hsa04115	0.84276716
55	GABAergic synapse_Homo sapiens_hsa04727	0.84036492
56	Morphine addiction_Homo sapiens_hsa05032	0.83081472
57	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.81930582
58	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81412338
59	Glutamatergic synapse_Homo sapiens_hsa04724	0.77145458
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.77053773
61	Insulin secretion_Homo sapiens_hsa04911	0.75772452
62	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74961407
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.72126212
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.71236372
65	Alcoholism_Homo sapiens_hsa05034	0.71157348
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.70749577
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.70605690
68	Dopaminergic synapse_Homo sapiens_hsa04728	0.69876468
69	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.62697835
70	Oocyte meiosis_Homo sapiens_hsa04114	0.60745573
71	Circadian entrainment_Homo sapiens_hsa04713	0.60499795
72	Amphetamine addiction_Homo sapiens_hsa05031	0.55959612
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53823409
74	Cocaine addiction_Homo sapiens_hsa05030	0.53704522
75	Long-term depression_Homo sapiens_hsa04730	0.52458536
76	Hippo signaling pathway_Homo sapiens_hsa04390	0.52007587
77	Sulfur metabolism_Homo sapiens_hsa00920	0.51997548
78	Metabolic pathways_Homo sapiens_hsa01100	0.51876847
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50091691
80	Serotonergic synapse_Homo sapiens_hsa04726	0.49363494
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.49332479
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49148047
83	Circadian rhythm_Homo sapiens_hsa04710	0.48032812
84	Caffeine metabolism_Homo sapiens_hsa00232	0.47579510
85	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46465837
86	Wnt signaling pathway_Homo sapiens_hsa04310	0.42314254
87	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.39047254
88	ABC transporters_Homo sapiens_hsa02010	0.38144947
89	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.37785322
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.36877340
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35225758
92	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.33414804
93	Axon guidance_Homo sapiens_hsa04360	0.32599298
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.31994597
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31140859
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.30845562
97	Lysine degradation_Homo sapiens_hsa00310	0.29948108
98	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.26177679
99	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.25711087
100	Calcium signaling pathway_Homo sapiens_hsa04020	0.22480775

C11ORF57

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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