C11ORF58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.56784077
2proteasome assembly (GO:0043248)4.96175299
3ATP synthesis coupled proton transport (GO:0015986)4.54521989
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54521989
5CENP-A containing nucleosome assembly (GO:0034080)4.53095449
6chromatin remodeling at centromere (GO:0031055)4.49361620
7establishment of integrated proviral latency (GO:0075713)4.45804421
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.40240129
9negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.29003464
10protein neddylation (GO:0045116)4.19041058
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.15844637
12regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.11163040
13cullin deneddylation (GO:0010388)3.99289729
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.99032514
15chaperone-mediated protein transport (GO:0072321)3.97689236
16histone exchange (GO:0043486)3.94934142
17negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.86544623
18negative regulation of ligase activity (GO:0051352)3.86544623
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.85871466
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.84540576
21exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.82527435
22DNA double-strand break processing (GO:0000729)3.78675939
23respiratory electron transport chain (GO:0022904)3.78280107
24electron transport chain (GO:0022900)3.70311009
25protein deneddylation (GO:0000338)3.66229158
26protein complex biogenesis (GO:0070271)3.64293622
27regulation of mitotic spindle checkpoint (GO:1903504)3.62938129
28regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.62938129
29transcription elongation from RNA polymerase III promoter (GO:0006385)3.62456887
30termination of RNA polymerase III transcription (GO:0006386)3.62456887
31regulation of cellular amino acid metabolic process (GO:0006521)3.60441509
32DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.58820018
33mitochondrial respiratory chain complex assembly (GO:0033108)3.58671507
34signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.56733803
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.56733803
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.56733803
37ribosome assembly (GO:0042255)3.56468661
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.53034762
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.53034762
40respiratory chain complex IV assembly (GO:0008535)3.51709034
41rRNA modification (GO:0000154)3.46554998
42DNA replication-independent nucleosome assembly (GO:0006336)3.46360853
43DNA replication-independent nucleosome organization (GO:0034724)3.46360853
44DNA damage response, detection of DNA damage (GO:0042769)3.42055601
45signal transduction involved in DNA damage checkpoint (GO:0072422)3.41129502
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41129502
47positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41103351
48signal transduction involved in cell cycle checkpoint (GO:0072395)3.38467629
49establishment of viral latency (GO:0019043)3.38402752
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.38162173
51spliceosomal snRNP assembly (GO:0000387)3.36753706
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.36644085
53NADH dehydrogenase complex assembly (GO:0010257)3.36644085
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36644085
55DNA replication checkpoint (GO:0000076)3.33246142
56regulation of mitochondrial translation (GO:0070129)3.31894889
57DNA ligation (GO:0006266)3.31030736
58positive regulation of ligase activity (GO:0051351)3.24194798
59water-soluble vitamin biosynthetic process (GO:0042364)3.23707145
60purine nucleobase biosynthetic process (GO:0009113)3.20229983
61DNA catabolic process, exonucleolytic (GO:0000738)3.16679382
62ribosomal large subunit biogenesis (GO:0042273)3.11634014
63regulation of ubiquitin-protein transferase activity (GO:0051438)3.11193594
64DNA strand elongation involved in DNA replication (GO:0006271)3.09958128
65cytochrome complex assembly (GO:0017004)3.09487191
66histone mRNA metabolic process (GO:0008334)3.09042125
67telomere maintenance via semi-conservative replication (GO:0032201)3.08098996
68ribosomal small subunit assembly (GO:0000028)3.08091510
69maturation of 5.8S rRNA (GO:0000460)3.06457437
70mitotic metaphase plate congression (GO:0007080)3.05802198
71inner mitochondrial membrane organization (GO:0007007)3.05245863
72double-strand break repair via nonhomologous end joining (GO:0006303)2.98665829
73non-recombinational repair (GO:0000726)2.98665829
74regulation of ligase activity (GO:0051340)2.98211075
75rRNA methylation (GO:0031167)2.96939184
76metaphase plate congression (GO:0051310)2.93760108
77DNA strand elongation (GO:0022616)2.91708242
78spindle checkpoint (GO:0031577)2.89912174
79somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.88425797
80somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.88425797
81isotype switching (GO:0045190)2.88425797
82organelle disassembly (GO:1903008)2.87926462
837-methylguanosine mRNA capping (GO:0006370)2.87699636
84protein targeting to mitochondrion (GO:0006626)2.86636897
85protein localization to kinetochore (GO:0034501)2.86100902
86tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85927031
87RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85927031
88IMP biosynthetic process (GO:0006188)2.85713325
89mitotic spindle checkpoint (GO:0071174)2.85686905
90protein-cofactor linkage (GO:0018065)2.84632945
91nucleobase biosynthetic process (GO:0046112)2.84491172
92kinetochore organization (GO:0051383)2.83915448
93translation (GO:0006412)2.83895727
94negative regulation of mitotic sister chromatid separation (GO:2000816)2.82472244
95negative regulation of sister chromatid segregation (GO:0033046)2.82472244
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82472244
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.82472244
98negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82472244
99replication fork processing (GO:0031297)2.80413974
1007-methylguanosine RNA capping (GO:0009452)2.79688374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.81142583
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.21529895
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.00191434
4E2F7_22180533_ChIP-Seq_HELA_Human3.50525363
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30894935
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19046235
7ELK1_19687146_ChIP-ChIP_HELA_Human3.05001928
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97812113
9* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83140565
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.78635077
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72661703
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.69701207
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.64638309
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.56869924
15VDR_23849224_ChIP-Seq_CD4+_Human2.47794759
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.39053260
17PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15602193
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10954514
19FOXP3_21729870_ChIP-Seq_TREG_Human2.09654303
20EWS_26573619_Chip-Seq_HEK293_Human2.08519047
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.04582964
22FUS_26573619_Chip-Seq_HEK293_Human2.04191248
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.99388759
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.97134420
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.94070156
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88558049
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86978070
28MYC_18940864_ChIP-ChIP_HL60_Human1.82216460
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81142250
30SRF_21415370_ChIP-Seq_HL-1_Mouse1.81096266
31* ZNF274_21170338_ChIP-Seq_K562_Hela1.80413769
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79423663
33VDR_22108803_ChIP-Seq_LS180_Human1.74085914
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73704573
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.72966909
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72415122
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68728307
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66717568
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.62483018
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61077501
41TTF2_22483619_ChIP-Seq_HELA_Human1.60126251
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59982838
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57143307
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55833544
45TAF15_26573619_Chip-Seq_HEK293_Human1.55411625
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.53559986
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.53448917
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49891176
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49682783
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45646342
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45061175
52IGF1R_20145208_ChIP-Seq_DFB_Human1.44415881
53AR_21909140_ChIP-Seq_LNCAP_Human1.41067817
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39932228
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39414367
56P300_19829295_ChIP-Seq_ESCs_Human1.35231587
57GABP_19822575_ChIP-Seq_HepG2_Human1.34251842
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.30157681
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.29392660
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29077428
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28970230
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.27019244
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26928196
64ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25160581
65XRN2_22483619_ChIP-Seq_HELA_Human1.23535503
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.18132589
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16227898
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14656202
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.13092002
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.12655347
71RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06875652
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06074761
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04587005
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.04323077
75SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03083864
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02477622
77IRF1_19129219_ChIP-ChIP_H3396_Human1.01978951
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.01925298
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01271715
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00834116
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99757529
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98756226
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96587179
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95817652
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91107433
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89685563
87TP53_22573176_ChIP-Seq_HFKS_Human0.89533769
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88853536
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.88388223
90NOTCH1_21737748_ChIP-Seq_TLL_Human0.87196188
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.85990571
92SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84940072
93SOX2_19829295_ChIP-Seq_ESCs_Human0.84401975
94NANOG_19829295_ChIP-Seq_ESCs_Human0.84401975
95GBX2_23144817_ChIP-Seq_PC3_Human0.83710204
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82946337
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82784085
98SALL4_22934838_ChIP-ChIP_CD34+_Human0.80490492
99HTT_18923047_ChIP-ChIP_STHdh_Human0.79844760
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78858509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.73267677
2MP0010094_abnormal_chromosome_stability3.49835732
3MP0004957_abnormal_blastocyst_morpholog3.16013290
4MP0003693_abnormal_embryo_hatching2.99410445
5MP0008877_abnormal_DNA_methylation2.87080508
6MP0003111_abnormal_nucleus_morphology2.51962862
7MP0003718_maternal_effect2.48430448
8MP0002938_white_spotting2.46743554
9MP0003077_abnormal_cell_cycle2.45337206
10MP0008057_abnormal_DNA_replication2.45261981
11MP0003136_yellow_coat_color2.40947169
12MP0002102_abnormal_ear_morphology2.36979685
13MP0006072_abnormal_retinal_apoptosis2.32513785
14MP0000372_irregular_coat_pigmentation2.32392568
15MP0006292_abnormal_olfactory_placode2.23128303
16MP0003890_abnormal_embryonic-extraembry2.20844000
17MP0008932_abnormal_embryonic_tissue2.17622994
18MP0003186_abnormal_redox_activity2.08214019
19MP0003806_abnormal_nucleotide_metabolis2.06426610
20MP0009697_abnormal_copulation2.05128211
21MP0008007_abnormal_cellular_replicative2.04152438
22MP0001293_anophthalmia1.98548289
23MP0003786_premature_aging1.90284999
24MP0003941_abnormal_skin_development1.82751027
25MP0003011_delayed_dark_adaptation1.76242257
26MP0003880_abnormal_central_pattern1.74239827
27MP0001529_abnormal_vocalization1.72129334
28MP0005253_abnormal_eye_physiology1.59392120
29MP0006036_abnormal_mitochondrial_physio1.58253584
30MP0001984_abnormal_olfaction1.56050659
31MP0005084_abnormal_gallbladder_morpholo1.55724899
32MP0010030_abnormal_orbit_morphology1.55135026
33MP0006035_abnormal_mitochondrial_morpho1.45643428
34MP0003567_abnormal_fetal_cardiomyocyte1.44274642
35MP0003121_genomic_imprinting1.40561864
36MP0002736_abnormal_nociception_after1.38834568
37MP0003937_abnormal_limbs/digits/tail_de1.37922103
38MP0005171_absent_coat_pigmentation1.34821016
39MP0002638_abnormal_pupillary_reflex1.32050505
40MP0004133_heterotaxia1.28964437
41MP0005075_abnormal_melanosome_morpholog1.24582425
42MP0008789_abnormal_olfactory_epithelium1.22131268
43MP0005408_hypopigmentation1.21045034
44MP0002210_abnormal_sex_determination1.20996574
45MP0002751_abnormal_autonomic_nervous1.20711348
46MP0008995_early_reproductive_senescence1.20517923
47MP0001286_abnormal_eye_development1.15943949
48MP0002233_abnormal_nose_morphology1.14858098
49MP0000647_abnormal_sebaceous_gland1.14710139
50MP0004147_increased_porphyrin_level1.11054558
51MP0002837_dystrophic_cardiac_calcinosis1.09938685
52MP0004215_abnormal_myocardial_fiber1.09862084
53MP0001929_abnormal_gametogenesis1.09576647
54MP0000350_abnormal_cell_proliferation1.07941567
55MP0001697_abnormal_embryo_size1.06009683
56MP0005645_abnormal_hypothalamus_physiol1.05365715
57MP0000631_abnormal_neuroendocrine_gland1.05226870
58MP0003195_calcinosis1.03891488
59MP0005551_abnormal_eye_electrophysiolog1.03708374
60MP0002095_abnormal_skin_pigmentation1.03342715
61MP0000653_abnormal_sex_gland1.03115790
62MP0002084_abnormal_developmental_patter1.02001333
63MP0002234_abnormal_pharynx_morphology1.01189269
64MP0006276_abnormal_autonomic_nervous1.01000085
65MP0003787_abnormal_imprinting1.00821686
66MP0001145_abnormal_male_reproductive0.99452758
67MP0001188_hyperpigmentation0.96922240
68MP0003119_abnormal_digestive_system0.96835946
69MP0001485_abnormal_pinna_reflex0.95920971
70MP0002160_abnormal_reproductive_system0.94347218
71MP0000358_abnormal_cell_content/0.93954305
72MP0005391_vision/eye_phenotype0.92364240
73MP0001730_embryonic_growth_arrest0.91919105
74MP0002085_abnormal_embryonic_tissue0.91210852
75MP0009379_abnormal_foot_pigmentation0.90143278
76MP0002282_abnormal_trachea_morphology0.87788970
77MP0002090_abnormal_vision0.87444408
78MP0001324_abnormal_eye_pigmentation0.85756229
79MP0008872_abnormal_physiological_respon0.83073574
80MP0003122_maternal_imprinting0.82583864
81MP0002697_abnormal_eye_size0.82508578
82MP0005389_reproductive_system_phenotype0.81946788
83MP0001672_abnormal_embryogenesis/_devel0.81147517
84MP0005380_embryogenesis_phenotype0.81147517
85MP0001119_abnormal_female_reproductive0.80068034
86MP0004142_abnormal_muscle_tone0.79437776
87MP0006054_spinal_hemorrhage0.78565122
88MP0002277_abnormal_respiratory_mucosa0.75065366
89MP0003283_abnormal_digestive_organ0.74294503
90MP0005395_other_phenotype0.73714671
91MP0005499_abnormal_olfactory_system0.73369958
92MP0005394_taste/olfaction_phenotype0.73369958
93MP0003698_abnormal_male_reproductive0.72449230
94MP0001177_atelectasis0.71441496
95MP0005379_endocrine/exocrine_gland_phen0.68927458
96MP0005174_abnormal_tail_pigmentation0.67548363
97MP0002088_abnormal_embryonic_growth/wei0.65649143
98MP0002163_abnormal_gland_morphology0.65226812
99MP0001905_abnormal_dopamine_level0.65205813
100MP0002080_prenatal_lethality0.65031943

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.48915679
2Increased hepatocellular lipid droplets (HP:0006565)4.06048564
3Acute encephalopathy (HP:0006846)3.99514708
4Progressive macrocephaly (HP:0004481)3.94042173
5Abnormal mitochondria in muscle tissue (HP:0008316)3.91707842
6Mitochondrial inheritance (HP:0001427)3.90070226
7Increased CSF lactate (HP:0002490)3.71807490
8Lipid accumulation in hepatocytes (HP:0006561)3.59434384
9Abnormality of the labia minora (HP:0012880)3.41484061
10Hepatocellular necrosis (HP:0001404)3.19225479
11Methylmalonic acidemia (HP:0002912)3.13683665
12Colon cancer (HP:0003003)3.10595874
13Renal Fanconi syndrome (HP:0001994)3.10046064
14Cerebral edema (HP:0002181)3.01743472
15Hepatic necrosis (HP:0002605)2.93867307
163-Methylglutaconic aciduria (HP:0003535)2.81012265
17Abnormality of methionine metabolism (HP:0010901)2.62481582
18Pancreatic cysts (HP:0001737)2.62119851
19Exertional dyspnea (HP:0002875)2.56520378
20Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53292100
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53292100
22Congenital, generalized hypertrichosis (HP:0004540)2.53252784
23Meckel diverticulum (HP:0002245)2.52489423
24Increased serum lactate (HP:0002151)2.50222573
25Pancreatic fibrosis (HP:0100732)2.44345943
26Abnormal lung lobation (HP:0002101)2.43439605
27Abnormality of midbrain morphology (HP:0002418)2.43419569
28Molar tooth sign on MRI (HP:0002419)2.43419569
29Methylmalonic aciduria (HP:0012120)2.42595277
30Aplastic anemia (HP:0001915)2.42336636
31Abnormality of the ileum (HP:0001549)2.42277903
32Type I transferrin isoform profile (HP:0003642)2.39275515
33Abnormality of the anterior horn cell (HP:0006802)2.36912551
34Degeneration of anterior horn cells (HP:0002398)2.36912551
35Increased intramyocellular lipid droplets (HP:0012240)2.34575983
36Lactic acidosis (HP:0003128)2.34238592
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34112507
38True hermaphroditism (HP:0010459)2.33575230
39Abnormality of chromosome stability (HP:0003220)2.30766343
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.29760769
41Volvulus (HP:0002580)2.28870443
42Leukodystrophy (HP:0002415)2.27245127
43Respiratory failure (HP:0002878)2.25422307
44Medial flaring of the eyebrow (HP:0010747)2.24923388
45Increased serum pyruvate (HP:0003542)2.23915018
46Abnormality of serum amino acid levels (HP:0003112)2.21668032
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20609608
48Abnormality of alanine metabolism (HP:0010916)2.20609608
49Hyperalaninemia (HP:0003348)2.20609608
50Macrocytic anemia (HP:0001972)2.17292952
51Reticulocytopenia (HP:0001896)2.16409304
52Optic disc pallor (HP:0000543)2.15506743
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14461516
54Chromsome breakage (HP:0040012)2.11647463
55Septo-optic dysplasia (HP:0100842)2.08973836
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08402371
57Exercise intolerance (HP:0003546)2.05564760
58Hyperglycinemia (HP:0002154)2.03724842
59Abnormal number of erythroid precursors (HP:0012131)2.03594336
60Nephronophthisis (HP:0000090)2.00363812
61Abnormality of the preputium (HP:0100587)1.99400202
62Duodenal stenosis (HP:0100867)1.98598762
63Small intestinal stenosis (HP:0012848)1.98598762
64Abnormality of renal resorption (HP:0011038)1.97530163
65Intestinal atresia (HP:0011100)1.95848747
66Abnormality of glycolysis (HP:0004366)1.95847108
67Lethargy (HP:0001254)1.95073723
68Abnormal protein glycosylation (HP:0012346)1.93382157
69Abnormal glycosylation (HP:0012345)1.93382157
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93382157
71Abnormal protein N-linked glycosylation (HP:0012347)1.93382157
72Respiratory difficulties (HP:0002880)1.91851293
73Stenosis of the external auditory canal (HP:0000402)1.91021829
74Abnormality of the duodenum (HP:0002246)1.89608255
75Abnormality of cells of the erythroid lineage (HP:0012130)1.89358513
76Abnormality of vitamin B metabolism (HP:0004340)1.88095197
77Short tibia (HP:0005736)1.87154408
78Neoplasm of the adrenal gland (HP:0100631)1.86455154
79Congenital primary aphakia (HP:0007707)1.84824710
80Supernumerary spleens (HP:0009799)1.84478369
81Birth length less than 3rd percentile (HP:0003561)1.82704874
82Oral leukoplakia (HP:0002745)1.81905616
83Neoplasm of the colon (HP:0100273)1.81691222
84Triphalangeal thumb (HP:0001199)1.81297054
85Pancytopenia (HP:0001876)1.80762702
86Bifid tongue (HP:0010297)1.80313227
87Abnormality of the vitamin B12 metabolism (HP:0004341)1.79845233
88Abnormality of the septum pellucidum (HP:0007375)1.79766386
89Microvesicular hepatic steatosis (HP:0001414)1.79084911
90Genital tract atresia (HP:0001827)1.78606850
91Hypothermia (HP:0002045)1.77539632
92Abnormality of the pons (HP:0007361)1.76427813
93Megaloblastic anemia (HP:0001889)1.75832984
94Renal cortical cysts (HP:0000803)1.75726529
95Absent septum pellucidum (HP:0001331)1.74800255
96Vaginal atresia (HP:0000148)1.74369915
97Gait imbalance (HP:0002141)1.72880117
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.72443527
99Median cleft lip (HP:0000161)1.71446701
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70783327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.51812112
2MST43.48822207
3VRK23.15498195
4SRPK12.74901230
5CDC72.68659714
6EIF2AK32.56506432
7TSSK62.31071423
8TRIM282.30433969
9PLK32.27531471
10NUAK12.26709790
11MKNK12.25822363
12MKNK22.22087529
13ZAK2.20832865
14EIF2AK12.19853652
15PBK2.12852190
16VRK12.05547540
17TNIK2.03764896
18WNK32.02824083
19TTK1.98740735
20STK161.96257825
21NEK11.95494428
22WEE11.92738434
23BMPR1B1.81489886
24BRSK21.78317235
25PLK41.75187713
26MAP4K21.74734719
27MAP3K121.66198925
28TAF11.53912161
29NME11.43651266
30BCR1.42569508
31ACVR1B1.33927333
32PASK1.33667488
33PLK21.32331236
34ERBB31.32222394
35PLK11.26298611
36FRK1.25484516
37STK38L1.22451461
38PNCK1.04035238
39GRK11.00485930
40EIF2AK20.99169387
41DYRK20.97292817
42CSNK1G10.89202031
43OXSR10.88312000
44ATR0.87419383
45ADRBK20.86882229
46MAP3K40.86789933
47STK30.84989924
48PDK20.84703154
49INSRR0.79610966
50AURKB0.79131309
51CSNK1G20.78512499
52CSNK1G30.76632750
53BRSK10.76604146
54CHEK20.76143670
55TGFBR10.69222436
56TAOK30.68117156
57BCKDK0.67382410
58PINK10.65848032
59ATM0.65454013
60DYRK30.64618294
61TLK10.64392850
62TXK0.62758409
63CDK190.60158874
64FGFR20.59073979
65FGFR10.58726618
66RPS6KA40.58366531
67STK40.57974327
68STK390.57260937
69CASK0.56596323
70STK240.55860045
71CSNK2A10.55848421
72CSNK2A20.55798060
73CCNB10.54157151
74NEK20.53391811
75CDK30.49902220
76CSNK1A1L0.49875574
77ALK0.48548263
78MAP2K70.48469862
79PAK30.46805654
80ERBB40.45576198
81PRKCG0.44114045
82PRKCE0.42797947
83CHEK10.42602524
84DAPK10.41159484
85RPS6KA50.40641042
86CSNK1E0.40342158
87MINK10.39945479
88NLK0.38587486
89CLK10.37015767
90CDK80.35043737
91MYLK0.33712048
92TEC0.32542194
93LATS10.30262332
94MAPK130.28276902
95CSNK1A10.25790119
96KDR0.25534046
97PRKDC0.25485416
98CDK10.25327164
99WNK40.24902397
100LIMK10.23992682

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.66912789
2Protein export_Homo sapiens_hsa030603.82998050
3Oxidative phosphorylation_Homo sapiens_hsa001903.46908613
4Mismatch repair_Homo sapiens_hsa034303.13869905
5Ribosome_Homo sapiens_hsa030103.04028374
6Parkinsons disease_Homo sapiens_hsa050123.04018843
7RNA polymerase_Homo sapiens_hsa030202.86174051
8DNA replication_Homo sapiens_hsa030302.83949513
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.69637620
10Homologous recombination_Homo sapiens_hsa034402.67154749
11Non-homologous end-joining_Homo sapiens_hsa034502.40218442
12Spliceosome_Homo sapiens_hsa030402.24245733
13Huntingtons disease_Homo sapiens_hsa050162.17963374
14Nucleotide excision repair_Homo sapiens_hsa034202.08115320
15Basal transcription factors_Homo sapiens_hsa030222.04212141
16RNA degradation_Homo sapiens_hsa030181.97530982
17RNA transport_Homo sapiens_hsa030131.95440264
18Alzheimers disease_Homo sapiens_hsa050101.91744735
19Fanconi anemia pathway_Homo sapiens_hsa034601.85109766
20One carbon pool by folate_Homo sapiens_hsa006701.77257806
21Propanoate metabolism_Homo sapiens_hsa006401.75028440
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74198200
23Base excision repair_Homo sapiens_hsa034101.65186524
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63017146
25Pyrimidine metabolism_Homo sapiens_hsa002401.50589444
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50067966
27Cell cycle_Homo sapiens_hsa041101.39359912
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31972620
29Purine metabolism_Homo sapiens_hsa002301.27409317
30Selenocompound metabolism_Homo sapiens_hsa004501.26133432
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26072884
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.24600320
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20335290
34Fatty acid elongation_Homo sapiens_hsa000621.19716605
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19615237
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17583187
37Folate biosynthesis_Homo sapiens_hsa007901.17304398
38Pyruvate metabolism_Homo sapiens_hsa006201.16884981
39Cardiac muscle contraction_Homo sapiens_hsa042601.11781300
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04180608
41Steroid biosynthesis_Homo sapiens_hsa001001.01582140
42Glutathione metabolism_Homo sapiens_hsa004800.94696736
43Phototransduction_Homo sapiens_hsa047440.89121098
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89092064
45Butanoate metabolism_Homo sapiens_hsa006500.87117422
46Oocyte meiosis_Homo sapiens_hsa041140.84816493
47mRNA surveillance pathway_Homo sapiens_hsa030150.83420415
48Peroxisome_Homo sapiens_hsa041460.75486424
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75410539
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72461870
51Metabolic pathways_Homo sapiens_hsa011000.71136272
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70245813
53Regulation of autophagy_Homo sapiens_hsa041400.69652739
54Sulfur metabolism_Homo sapiens_hsa009200.69650980
55Tryptophan metabolism_Homo sapiens_hsa003800.65657150
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.64628095
57Caffeine metabolism_Homo sapiens_hsa002320.64197630
58Nitrogen metabolism_Homo sapiens_hsa009100.63347521
59Collecting duct acid secretion_Homo sapiens_hsa049660.62565378
60Vitamin B6 metabolism_Homo sapiens_hsa007500.60726735
61p53 signaling pathway_Homo sapiens_hsa041150.60024466
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.58573836
63Carbon metabolism_Homo sapiens_hsa012000.55490588
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53554519
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50364793
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49810237
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49757998
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47769887
69Chemical carcinogenesis_Homo sapiens_hsa052040.47655607
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47329686
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42157551
72N-Glycan biosynthesis_Homo sapiens_hsa005100.42131956
73TGF-beta signaling pathway_Homo sapiens_hsa043500.41447127
74Retinol metabolism_Homo sapiens_hsa008300.40895787
75beta-Alanine metabolism_Homo sapiens_hsa004100.37466574
76Biosynthesis of amino acids_Homo sapiens_hsa012300.37085905
77Circadian rhythm_Homo sapiens_hsa047100.34930584
78Fatty acid metabolism_Homo sapiens_hsa012120.34008214
79Fatty acid degradation_Homo sapiens_hsa000710.33981764
80Epstein-Barr virus infection_Homo sapiens_hsa051690.33329727
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30971729
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28591120
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28133076
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27981913
85Hedgehog signaling pathway_Homo sapiens_hsa043400.25208662
86Basal cell carcinoma_Homo sapiens_hsa052170.24376008
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.22789240
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.22754068
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21775794
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21477310
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.21089366
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19878995
93Vitamin digestion and absorption_Homo sapiens_hsa049770.19708360
94Wnt signaling pathway_Homo sapiens_hsa043100.17931102
95Olfactory transduction_Homo sapiens_hsa047400.16771520
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.16771096
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16386139
98Nicotine addiction_Homo sapiens_hsa050330.16244376
99Hippo signaling pathway_Homo sapiens_hsa043900.15941546
100Tyrosine metabolism_Homo sapiens_hsa003500.14160082

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