ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to endosome (GO:0036010)	4.12030901
2	negative regulation of erythrocyte differentiation (GO:0045647)	3.99949845
3	regulation of early endosome to late endosome transport (GO:2000641)	3.87586816
4	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.70620942
5	stress fiber assembly (GO:0043149)	3.68602807
6	barbed-end actin filament capping (GO:0051016)	3.55904534
7	negative regulation of cell size (GO:0045792)	3.40685617
8	protein retention in ER lumen (GO:0006621)	3.35273605
9	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.29659428
10	skin morphogenesis (GO:0043589)	3.22460182
11	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.10940571
12	negative regulation of necrotic cell death (GO:0060547)	3.05519894
13	regulation of T-helper 2 cell differentiation (GO:0045628)	3.02983513
14	Golgi transport vesicle coating (GO:0048200)	3.01073692
15	COPI coating of Golgi vesicle (GO:0048205)	3.01073692
16	positive regulation of protein dephosphorylation (GO:0035307)	2.98977166
17	response to peptidoglycan (GO:0032494)	2.95381775
18	modulation by symbiont of host cellular process (GO:0044068)	2.86805786
19	regulation of extracellular matrix disassembly (GO:0010715)	2.85033534
20	positive regulation of blood vessel endothelial cell migration (GO:0043536)	2.84166553
21	positive regulation of fibroblast migration (GO:0010763)	2.82843270
22	adhesion of symbiont to host cell (GO:0044650)	2.82559955
23	virion attachment to host cell (GO:0019062)	2.82559955
24	signal complex assembly (GO:0007172)	2.78923754
25	focal adhesion assembly (GO:0048041)	2.77780677
26	cell-substrate adherens junction assembly (GO:0007045)	2.77780677
27	regulation of necrotic cell death (GO:0010939)	2.77400039
28	pinocytosis (GO:0006907)	2.76263221
29	adherens junction assembly (GO:0034333)	2.75862928
30	positive regulation of receptor recycling (GO:0001921)	2.75816718
31	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.74524693
32	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.74524693
33	modulation by symbiont of host immune response (GO:0052553)	2.74524693
34	positive regulation by symbiont of host defense response (GO:0052509)	2.74524693
35	modulation by symbiont of host defense response (GO:0052031)	2.74524693
36	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.74524693
37	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.74280131
38	vascular endothelial growth factor receptor signaling pathway (GO:0048010)	2.72004404
39	protein targeting to plasma membrane (GO:0072661)	2.69726065
40	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	2.65995448
41	activation of Rac GTPase activity (GO:0032863)	2.61480549
42	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.60860328
43	negative regulation of cell killing (GO:0031342)	2.60860328
44	adhesion of symbiont to host (GO:0044406)	2.60323659
45	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	2.58860422
46	cell-substrate junction assembly (GO:0007044)	2.58424196
47	modulation by virus of host process (GO:0019054)	2.57323947
48	retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)	2.57036190
49	mannose metabolic process (GO:0006013)	2.56947272
50	positive regulation of extracellular matrix organization (GO:1903055)	2.56800496
51	positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)	2.56256929
52	endoplasmic reticulum calcium ion homeostasis (GO:0032469)	2.52985052
53	negative regulation of necroptotic process (GO:0060546)	2.52576359
54	regulation of mammary gland epithelial cell proliferation (GO:0033599)	2.52276163
55	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.51509686
56	regulation of macrophage cytokine production (GO:0010935)	2.50615605
57	adenosine receptor signaling pathway (GO:0001973)	2.49705356
58	cortical actin cytoskeleton organization (GO:0030866)	2.48413554
59	regulation of ARF protein signal transduction (GO:0032012)	2.48408794
60	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.46511136
61	activation of MAPKKK activity (GO:0000185)	2.45737506
62	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.45483863
63	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	2.45239399
64	positive regulation of membrane protein ectodomain proteolysis (GO:0051044)	2.44575694
65	response to laminar fluid shear stress (GO:0034616)	2.44273635
66	negative regulation of amyloid precursor protein catabolic process (GO:1902992)	2.43111517
67	antigen processing and presentation of endogenous antigen (GO:0019883)	2.41065105
68	peptidyl-proline hydroxylation (GO:0019511)	2.40865936
69	endocytic recycling (GO:0032456)	2.38262367
70	hypotonic response (GO:0006971)	2.37800299
71	extracellular fibril organization (GO:0043206)	2.36915284
72	fibril organization (GO:0097435)	2.34657964
73	cell-cell junction maintenance (GO:0045217)	2.34160110
74	lipopolysaccharide-mediated signaling pathway (GO:0031663)	2.33922410
75	regulation of response to osmotic stress (GO:0047484)	2.33666875
76	glutamate secretion (GO:0014047)	2.33613656
77	hyaluronan catabolic process (GO:0030214)	2.32342812
78	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.32180335
79	positive regulation of macrophage cytokine production (GO:0060907)	2.31682814
80	UV protection (GO:0009650)	2.30462215
81	substrate-dependent cell migration (GO:0006929)	2.30024048
82	synaptic vesicle exocytosis (GO:0016079)	2.29875953
83	response to host defenses (GO:0052200)	2.29445865
84	response to defenses of other organism involved in symbiotic interaction (GO:0052173)	2.29445865
85	response to host (GO:0075136)	2.29445865
86	macrophage activation involved in immune response (GO:0002281)	2.29279240
87	endodermal cell differentiation (GO:0035987)	2.29247273
88	platelet aggregation (GO:0070527)	2.28776805
89	regulation of apoptotic process involved in morphogenesis (GO:1902337)	2.26995837
90	regulation of leukocyte degranulation (GO:0043300)	2.26532339
91	protein maturation by protein folding (GO:0022417)	2.22633335
92	regulation of protein dephosphorylation (GO:0035304)	2.22142978
93	regulation of ARF GTPase activity (GO:0032312)	2.21715067
94	modulation by virus of host morphology or physiology (GO:0019048)	2.21572239
95	protein hydroxylation (GO:0018126)	2.21269617
96	cortical cytoskeleton organization (GO:0030865)	2.20122096
97	pentose-phosphate shunt (GO:0006098)	2.18775272
98	regulation of syncytium formation by plasma membrane fusion (GO:0060142)	2.18648443
99	positive regulation of myotube differentiation (GO:0010831)	2.17793280
100	actin filament bundle organization (GO:0061572)	2.17178853

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.32023642
2	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.27657256
3	* LXR_22292898_ChIP-Seq_THP-1_Human	2.96908845
4	* ELK3_25401928_ChIP-Seq_HUVEC_Human	2.82203016
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.55312840
6	KDM2B_26808549_Chip-Seq_SUP-B15_Human	2.46914561
7	VDR_21846776_ChIP-Seq_THP-1_Human	2.42857227
8	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	2.33542410
9	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.19836081
10	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	2.18676295
11	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	2.18049811
12	* RACK7_27058665_Chip-Seq_MCF-7_Human	2.15729343
13	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.09175779
14	* KDM2B_26808549_Chip-Seq_DND41_Human	2.05699509
15	KDM2B_26808549_Chip-Seq_K562_Human	1.89994013
16	MYC_22102868_ChIP-Seq_BL_Human	1.89390777
17	TCF7_22412390_ChIP-Seq_EML_Mouse	1.85830098
18	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.82951869
19	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.82588314
20	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.76132378
21	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.73511374
22	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.68273131
23	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.67809611
24	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.65053489
25	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.61450058
26	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.61373551
27	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.60345617
28	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.59859134
29	VDR_24763502_ChIP-Seq_THP-1_Human	1.59368888
30	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.59209507
31	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.57333772
32	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.56276812
33	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.55333909
34	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.54174296
35	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.53010740
36	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.52509554
37	P68_20966046_ChIP-Seq_HELA_Human	1.51897465
38	ZNF263_19887448_ChIP-Seq_K562_Human	1.45221141
39	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.44459496
40	* P300_27058665_Chip-Seq_ZR-75-30cells_Human	1.43146250
41	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.42678784
42	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.41926856
43	MAF_26560356_Chip-Seq_TH1_Human	1.39312498
44	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.38429892
45	SMC4_20622854_ChIP-Seq_HELA_Human	1.37952583
46	RUNX1_22412390_ChIP-Seq_EML_Mouse	1.36882261
47	* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.36639313
48	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.35554103
49	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.34785968
50	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.33294404
51	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.33211280
52	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.32647887
53	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	1.31313171
54	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29873397
55	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.29548773
56	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.28229609
57	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.28194871
58	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.28193093
59	* TP53_22127205_ChIP-Seq_IMR90_Human	1.27963932
60	MAF_26560356_Chip-Seq_TH2_Human	1.27296562
61	* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.26899964
62	CLOCK_20551151_ChIP-Seq_293T_Human	1.26721686
63	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.25727617
64	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.25313559
65	* ATF3_27146783_Chip-Seq_COLON_Human	1.24092821
66	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.23179972
67	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.22779033
68	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.21577439
69	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.20130401
70	NCOR1_26117541_ChIP-Seq_K562_Human	1.19681395
71	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.19397642
72	BCL6_27268052_Chip-Seq_Bcells_Human	1.19264016
73	UTX_26944678_Chip-Seq_JUKART_Human	1.18302853
74	BCOR_27268052_Chip-Seq_Bcells_Human	1.17826192
75	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.17803640
76	CREB1_26743006_Chip-Seq_LNCaP_Human	1.15922690
77	SPI1_23127762_ChIP-Seq_K562_Human	1.15545957
78	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.14616398
79	CTCF_27219007_Chip-Seq_Bcells_Human	1.13733311
80	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.13606002
81	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.12665729
82	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.12306163
83	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.11703652
84	GATA1_19941826_ChIP-Seq_K562_Human	1.11219441
85	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.10163400
86	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.08207301
87	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.07907688
88	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.07450676
89	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.06587183
90	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.06478350
91	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.05150619
92	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.05112271
93	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.04887169
94	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.04018861
95	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.02789543
96	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.00449743
97	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.98298012
98	PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.98147981
99	SA1_27219007_Chip-Seq_Bcells_Human	0.96254025
100	UBF1/2_26484160_Chip-Seq_HMECs_Human	0.95951955

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008438_abnormal_cutaneous_collagen	4.27953911
2	MP0003705_abnormal_hypodermis_morpholog	4.27537799
3	MP0005058_abnormal_lysosome_morphology	3.19259784
4	MP0003191_abnormal_cellular_cholesterol	3.02973727
5	MP0009840_abnormal_foam_cell	2.74342768
6	MP0005451_abnormal_body_composition	2.71528242
7	MP0004510_myositis	2.65196718
8	MP0003436_decreased_susceptibility_to	2.56176575
9	MP0003279_aneurysm	2.51952400
10	MP0003303_peritoneal_inflammation	2.42742642
11	MP0009278_abnormal_bone_marrow	2.41952887
12	MP0003566_abnormal_cell_adhesion	2.34761778
13	MP0001958_emphysema	2.25072767
14	MP0004859_abnormal_synaptic_plasticity	2.24787386
15	MP0004858_abnormal_nervous_system	2.20869911
16	MP0000751_myopathy	2.17209234
17	MP0008260_abnormal_autophagy	2.07213172
18	MP0003172_abnormal_lysosome_physiology	2.04049209
19	MP0003329_amyloid_beta_deposits	1.85264683
20	MP0005623_abnormal_meninges_morphology	1.84615290
21	MP0003300_gastrointestinal_ulcer	1.83953722
22	MP0005464_abnormal_platelet_physiology	1.79127243
23	MP0003075_altered_response_to	1.76841334
24	MP0003091_abnormal_cell_migration	1.71847313
25	MP0001849_ear_inflammation	1.69107088
26	MP0005023_abnormal_wound_healing	1.66308755
27	MP0001533_abnormal_skeleton_physiology	1.59688999
28	MP0005257_abnormal_intraocular_pressure	1.56367517
29	MP0004272_abnormal_basement_membrane	1.56059732
30	MP0000858_altered_metastatic_potential	1.55543944
31	MP0000343_altered_response_to	1.49485710
32	MP0001542_abnormal_bone_strength	1.46709602
33	MP0002877_abnormal_melanocyte_morpholog	1.39605008
34	MP0001545_abnormal_hematopoietic_system	1.37975162
35	MP0005397_hematopoietic_system_phenotyp	1.37975162
36	MP0004947_skin_inflammation	1.36970871
37	MP0002419_abnormal_innate_immunity	1.33565693
38	MP0000604_amyloidosis	1.33021331
39	MP0003879_abnormal_hair_cell	1.31800226
40	MP0000759_abnormal_skeletal_muscle	1.27522764
41	MP0002998_abnormal_bone_remodeling	1.25503550
42	MP0001348_abnormal_lacrimal_gland	1.24739049
43	MP0006082_CNS_inflammation	1.23147848
44	MP0005503_abnormal_tendon_morphology	1.21999410
45	MP0005390_skeleton_phenotype	1.20775530
46	MP0000749_muscle_degeneration	1.20413564
47	MP0003828_pulmonary_edema	1.20019797
48	MP0005275_abnormal_skin_tensile	1.16423107
49	MP0003724_increased_susceptibility_to	1.15320730
50	MP0005025_abnormal_response_to	1.14045948
51	MP0000767_abnormal_smooth_muscle	1.12054256
52	MP0000750_abnormal_muscle_regeneration	1.11672858
53	MP0003453_abnormal_keratinocyte_physiol	1.09404557
54	MP0000920_abnormal_myelination	1.06508195
55	MP0005000_abnormal_immune_tolerance	1.05681296
56	MP0008874_decreased_physiological_sensi	1.05555292
57	MP0005076_abnormal_cell_differentiation	1.05319758
58	MP0000747_muscle_weakness	1.03082669
59	MP0010368_abnormal_lymphatic_system	1.02322427
60	MP0005166_decreased_susceptibility_to	1.01713148
61	MP0003634_abnormal_glial_cell	1.01280501
62	MP0008004_abnormal_stomach_pH	0.99529510
63	MP0002060_abnormal_skin_morphology	0.99300139
64	MP0004185_abnormal_adipocyte_glucose	0.98916642
65	MP0005375_adipose_tissue_phenotype	0.98752029
66	MP0005164_abnormal_response_to	0.97849047
67	MP0000685_abnormal_immune_system	0.97829353
68	MP0005666_abnormal_adipose_tissue	0.97139376
69	MP0003448_altered_tumor_morphology	0.96548105
70	MP0000003_abnormal_adipose_tissue	0.96279640
71	MP0000733_abnormal_muscle_development	0.94521410
72	MP0004233_abnormal_muscle_weight	0.94127103
73	MP0002295_abnormal_pulmonary_circulatio	0.93723090
74	MP0002089_abnormal_postnatal_growth/wei	0.93280117
75	MP0002148_abnormal_hypersensitivity_rea	0.92759330
76	MP0005165_increased_susceptibility_to	0.92019369
77	MP0009384_cardiac_valve_regurgitation	0.91240522
78	MP0000678_abnormal_parathyroid_gland	0.90414312
79	MP0005595_abnormal_vascular_smooth	0.87124576
80	MP0005508_abnormal_skeleton_morphology	0.86667602
81	MP0003690_abnormal_glial_cell	0.85193281
82	MP0002332_abnormal_exercise_endurance	0.83963636
83	MP0004087_abnormal_muscle_fiber	0.82134275
84	MP0002933_joint_inflammation	0.81521197
85	MP0002896_abnormal_bone_mineralization	0.80650061
86	MP0005387_immune_system_phenotype	0.80462246
87	MP0001790_abnormal_immune_system	0.80462246
88	MP0001851_eye_inflammation	0.78926102
89	MP0008569_lethality_at_weaning	0.78000124
90	MP0003795_abnormal_bone_structure	0.75869208
91	MP0000681_abnormal_thyroid_gland	0.75376152
92	MP0009333_abnormal_splenocyte_physiolog	0.74737682
93	MP0009785_altered_susceptibility_to	0.74476343
94	MP0005621_abnormal_cell_physiology	0.73609773
95	MP0005670_abnormal_white_adipose	0.73154247
96	MP0002723_abnormal_immune_serum	0.65488906
97	MP0002420_abnormal_adaptive_immunity	0.64218590
98	MP0001819_abnormal_immune_cell	0.63774869
99	MP0005409_darkened_coat_color	0.63589216
100	MP0005330_cardiomyopathy	0.63440299

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Protrusio acetabuli (HP:0003179)	4.70890982
2	Premature rupture of membranes (HP:0001788)	4.37928510
3	Vertebral compression fractures (HP:0002953)	3.76205523
4	Increased variability in muscle fiber diameter (HP:0003557)	3.11683611
5	Type 1 muscle fiber predominance (HP:0003803)	3.03701215
6	Increased connective tissue (HP:0009025)	3.01199002
7	Upper limb amyotrophy (HP:0009129)	2.95837937
8	Distal upper limb amyotrophy (HP:0007149)	2.95837937
9	Fragile skin (HP:0001030)	2.95366583
10	Abnormality of skeletal muscle fiber size (HP:0012084)	2.93831502
11	Distal lower limb muscle weakness (HP:0009053)	2.90185402
12	Spinal rigidity (HP:0003306)	2.83939826
13	Distal lower limb amyotrophy (HP:0008944)	2.81113672
14	Achilles tendon contracture (HP:0001771)	2.77336133
15	Supranuclear gaze palsy (HP:0000605)	2.66227908
16	Cervical subluxation (HP:0003308)	2.64624540
17	Obstructive sleep apnea (HP:0002870)	2.63834471
18	Cerebral aneurysm (HP:0004944)	2.59496395
19	Slender build (HP:0001533)	2.59317938
20	Dysostosis multiplex (HP:0000943)	2.56690582
21	Hyperacusis (HP:0010780)	2.55391930
22	Vascular tortuosity (HP:0004948)	2.52919568
23	Ankle contracture (HP:0006466)	2.52711781
24	Abnormality of glycolipid metabolism (HP:0010969)	2.47332012
25	Abnormality of liposaccharide metabolism (HP:0010968)	2.47332012
26	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.47332012
27	Abnormality of the Achilles tendon (HP:0005109)	2.44227122
28	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.42806181
29	Neurofibrillary tangles (HP:0002185)	2.41633693
30	Nuclear cataract (HP:0100018)	2.41374373
31	Difficulty climbing stairs (HP:0003551)	2.36631015
32	Arterial tortuosity (HP:0005116)	2.35747462
33	Axonal loss (HP:0003447)	2.35579905
34	Aortic aneurysm (HP:0004942)	2.32587598
35	Atrophic scars (HP:0001075)	2.32533766
36	Mildly elevated creatine phosphokinase (HP:0008180)	2.30465428
37	Blue sclerae (HP:0000592)	2.28424289
38	Hand muscle atrophy (HP:0009130)	2.26411424
39	Spondylolisthesis (HP:0003302)	2.23663087
40	Mitral regurgitation (HP:0001653)	2.22932366
41	Dilatation of the ascending aorta (HP:0005111)	2.22169904
42	Bladder diverticulum (HP:0000015)	2.20587302
43	Myopathic facies (HP:0002058)	2.19129731
44	Lower limb amyotrophy (HP:0007210)	2.18741543
45	Exercise-induced myalgia (HP:0003738)	2.18013782
46	Shallow orbits (HP:0000586)	2.17007767
47	Cerebral inclusion bodies (HP:0100314)	2.16578996
48	Genu recurvatum (HP:0002816)	2.16561385
49	Insomnia (HP:0100785)	2.15889716
50	Wormian bones (HP:0002645)	2.15462864
51	Asymmetric septal hypertrophy (HP:0001670)	2.12104861
52	Aortic dissection (HP:0002647)	2.11015145
53	Peritonitis (HP:0002586)	2.10965909
54	Broad face (HP:0000283)	2.10473845
55	Short nail (HP:0001799)	2.09092600
56	Cellulitis (HP:0100658)	2.09010630
57	Generalized amyotrophy (HP:0003700)	2.08518464
58	Abnormality of macrophages (HP:0004311)	2.06378804
59	Biconcave vertebral bodies (HP:0004586)	2.05847655
60	Stridor (HP:0010307)	1.99511050
61	Joint stiffness (HP:0001387)	1.99074050
62	Neuronal loss in central nervous system (HP:0002529)	1.98989041
63	Abnormality of dentin (HP:0010299)	1.97834603
64	Broad metatarsal (HP:0001783)	1.97299768
65	Purpura (HP:0000979)	1.95569395
66	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.94480915
67	Abnormality of polysaccharide metabolism (HP:0011012)	1.94480915
68	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.94480915
69	Disproportionate tall stature (HP:0001519)	1.92577939
70	Aneurysm (HP:0002617)	1.92330335
71	Loss of speech (HP:0002371)	1.91412615
72	Mucopolysacchariduria (HP:0008155)	1.90027041
73	Urinary glycosaminoglycan excretion (HP:0003541)	1.90027041
74	Hypertensive crisis (HP:0100735)	1.89858202
75	Round ear (HP:0100830)	1.89778003
76	Polygenic inheritance (HP:0010982)	1.86682646
77	Hypoventilation (HP:0002791)	1.83960070
78	Polycythemia (HP:0001901)	1.83319919
79	Emphysema (HP:0002097)	1.82622326
80	Bulbar palsy (HP:0001283)	1.80507236
81	Hyperparathyroidism (HP:0000843)	1.77185414
82	Segmental peripheral demyelination/remyelination (HP:0003481)	1.76716173
83	Eczematoid dermatitis (HP:0000976)	1.76698544
84	Muscle fiber splitting (HP:0003555)	1.76443081
85	Foot dorsiflexor weakness (HP:0009027)	1.76244034
86	Hyperextensible skin (HP:0000974)	1.74950426
87	Elbow flexion contracture (HP:0002987)	1.74376643
88	Petechiae (HP:0000967)	1.73078936
89	Amyloidosis (HP:0011034)	1.72813946
90	Ulnar bowing (HP:0003031)	1.72035665
91	Joint laxity (HP:0001388)	1.71561124
92	Coxa vara (HP:0002812)	1.64978715
93	Interstitial pulmonary disease (HP:0006530)	1.62042127
94	Soft skin (HP:0000977)	1.61778663
95	Easy fatigability (HP:0003388)	1.61671833
96	Neonatal short-limb short stature (HP:0008921)	1.61070973
97	Abnormality of the nasal mucosa (HP:0000433)	1.60486423
98	Upper motor neuron abnormality (HP:0002127)	1.60078361
99	Hyporeflexia of lower limbs (HP:0002600)	1.59123488
100	Abnormal gallbladder physiology (HP:0012438)	1.58040844

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	3.43233735
2	MAP3K11	3.36789953
3	TRIB3	3.17906637
4	PRPF4B	2.80647228
5	IRAK3	2.52081606
6	MAP2K3	2.42815516
7	SIK1	2.30222352
8	ICK	2.07122530
9	TAOK2	2.06310967
10	TESK1	2.05276688
11	SMG1	1.94412121
12	NME2	1.90717030
13	RIPK1	1.89942436
14	TTN	1.88226536
15	EPHA2	1.78965298
16	ARAF	1.78791587
17	PRKD2	1.78013464
18	EPHB1	1.70347020
19	PAK4	1.66361273
20	MAP3K13	1.62966283
21	RIPK4	1.60448595
22	TAOK1	1.60074217
23	MAP3K3	1.58004671
24	MAP4K1	1.57948216
25	PRKD3	1.51692474
26	MAP3K1	1.50255116
27	MOS	1.44338892
28	MARK2	1.32885843
29	PIM2	1.32297622
30	PTK2	1.32227422
31	TESK2	1.26475376
32	PDGFRA	1.26332824
33	PAK6	1.25740825
34	TBK1	1.23256978
35	STK38	1.16521809
36	KSR2	1.15900577
37	NTRK1	1.13062406
38	DDR2	1.07286889
39	LIMK1	1.03626921
40	IRAK4	1.02280733
41	DYRK1B	1.00668530
42	MST1R	0.96407629
43	BRAF	0.95912820
44	BMX	0.93363561
45	PDPK1	0.92777035
46	CDC42BPA	0.91703474
47	TGFBR2	0.91511223
48	LATS2	0.90446266
49	TNK2	0.89223801
50	PRKG2	0.88973082
51	LMTK2	0.88729354
52	SIK2	0.86837423
53	PTK6	0.85196574
54	TYK2	0.81310837
55	SIK3	0.80867652
56	MYLK	0.78347276
57	MAPK12	0.78033858
58	ABL2	0.76892901
59	ZAP70	0.76874043
60	IRAK2	0.75954159
61	DAPK3	0.72028897
62	PKN2	0.68932157
63	RPS6KA2	0.68833939
64	JAK3	0.68764857
65	EPHB2	0.66419133
66	MAP3K9	0.65938812
67	HIPK2	0.65764537
68	SCYL2	0.63423024
69	MAP3K8	0.61314708
70	CSK	0.57974504
71	PAK2	0.57667331
72	MTOR	0.57104862
73	PDK1	0.55044990
74	MAP3K7	0.54401003
75	DMPK	0.52796784
76	LRRK2	0.52647751
77	ROCK2	0.52381900
78	PAK1	0.51835272
79	ILK	0.51095406
80	PTK2B	0.50864742
81	DAPK1	0.49933635
82	PHKG2	0.49656120
83	PHKG1	0.49656120
84	FGFR4	0.48948480
85	GRK5	0.48846170
86	DAPK2	0.48732921
87	RPS6KC1	0.47543432
88	RPS6KL1	0.47543432
89	PRKCH	0.47057220
90	FES	0.46650373
91	MAPK7	0.46432444
92	CDK12	0.44946977
93	MAP3K6	0.44398283
94	RAF1	0.41300570
95	CAMK2G	0.39056623
96	CAMKK1	0.39003477
97	MAP3K14	0.38559807
98	CDK11A	0.37755455
99	MAP3K12	0.37226842
100	GRK6	0.37016070

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.62930178
2	Other glycan degradation_Homo sapiens_hsa00511	2.56973579
3	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.80834942
4	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.76297679
5	Osteoclast differentiation_Homo sapiens_hsa04380	1.71758577
6	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.65891893
7	Acute myeloid leukemia_Homo sapiens_hsa05221	1.62177038
8	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.58016488
9	VEGF signaling pathway_Homo sapiens_hsa04370	1.56646475
10	Prion diseases_Homo sapiens_hsa05020	1.56576379
11	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.48731186
12	Bladder cancer_Homo sapiens_hsa05219	1.48132888
13	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.44414995
14	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.42063371
15	Pentose phosphate pathway_Homo sapiens_hsa00030	1.41049346
16	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.39845969
17	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.38616207
18	Malaria_Homo sapiens_hsa05144	1.37266894
19	Non-small cell lung cancer_Homo sapiens_hsa05223	1.36031288
20	Amoebiasis_Homo sapiens_hsa05146	1.34822382
21	Focal adhesion_Homo sapiens_hsa04510	1.33750065
22	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.32756842
23	Lysosome_Homo sapiens_hsa04142	1.30746874
24	Endocytosis_Homo sapiens_hsa04144	1.29079795
25	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.27145536
26	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.22898452
27	Pancreatic cancer_Homo sapiens_hsa05212	1.20597845
28	Leishmaniasis_Homo sapiens_hsa05140	1.19419812
29	Neurotrophin signaling pathway_Homo sapiens_hsa04722	1.19401452
30	Central carbon metabolism in cancer_Homo sapiens_hsa05230	1.17421795
31	Long-term potentiation_Homo sapiens_hsa04720	1.16668357
32	Shigellosis_Homo sapiens_hsa05131	1.14957258
33	Salmonella infection_Homo sapiens_hsa05132	1.14456069
34	Glioma_Homo sapiens_hsa05214	1.13620940
35	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	1.12675477
36	Phospholipase D signaling pathway_Homo sapiens_hsa04072	1.12518514
37	Notch signaling pathway_Homo sapiens_hsa04330	1.11423938
38	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.09873498
39	GnRH signaling pathway_Homo sapiens_hsa04912	1.09024119
40	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.06789825
41	Vibrio cholerae infection_Homo sapiens_hsa05110	1.03945594
42	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.03078196
43	TNF signaling pathway_Homo sapiens_hsa04668	1.02086637
44	ECM-receptor interaction_Homo sapiens_hsa04512	1.01174369
45	Tuberculosis_Homo sapiens_hsa05152	1.01049483
46	Galactose metabolism_Homo sapiens_hsa00052	1.00493143
47	Renal cell carcinoma_Homo sapiens_hsa05211	1.00032636
48	ErbB signaling pathway_Homo sapiens_hsa04012	0.99881020
49	Proteoglycans in cancer_Homo sapiens_hsa05205	0.99063840
50	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.99037485
51	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.93653375
52	Toxoplasmosis_Homo sapiens_hsa05145	0.92600249
53	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.91596019
54	Platelet activation_Homo sapiens_hsa04611	0.91524145
55	Insulin signaling pathway_Homo sapiens_hsa04910	0.90517661
56	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.90501876
57	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.90465796
58	Endometrial cancer_Homo sapiens_hsa05213	0.89436763
59	Pertussis_Homo sapiens_hsa05133	0.88951806
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87457987
61	Phagosome_Homo sapiens_hsa04145	0.86317613
62	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81416719
63	African trypanosomiasis_Homo sapiens_hsa05143	0.80131253
64	Hepatitis B_Homo sapiens_hsa05161	0.79197867
65	Hepatitis C_Homo sapiens_hsa05160	0.78476188
66	Apoptosis_Homo sapiens_hsa04210	0.78315559
67	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.76958879
68	Rap1 signaling pathway_Homo sapiens_hsa04015	0.76879120
69	Chemokine signaling pathway_Homo sapiens_hsa04062	0.76354084
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.74023212
71	mTOR signaling pathway_Homo sapiens_hsa04150	0.73084544
72	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.72232897
73	MAPK signaling pathway_Homo sapiens_hsa04010	0.72159177
74	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.71494150
75	Influenza A_Homo sapiens_hsa05164	0.70888962
76	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.68495300
77	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.66876031
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.66723963
79	Small cell lung cancer_Homo sapiens_hsa05222	0.66680196
80	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.64662861
81	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.64186788
82	Gap junction_Homo sapiens_hsa04540	0.63645148
83	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.63145168
84	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.62123332
85	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.61954803
86	Viral myocarditis_Homo sapiens_hsa05416	0.61663014
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61408346
88	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.61248336
89	Thyroid cancer_Homo sapiens_hsa05216	0.60536507
90	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.59253832
91	HTLV-I infection_Homo sapiens_hsa05166	0.59102248
92	Gastric acid secretion_Homo sapiens_hsa04971	0.59050606
93	Prolactin signaling pathway_Homo sapiens_hsa04917	0.57441118
94	AMPK signaling pathway_Homo sapiens_hsa04152	0.55894220
95	Melanogenesis_Homo sapiens_hsa04916	0.54075382
96	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.52773596
97	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50039798
98	Measles_Homo sapiens_hsa05162	0.49504400
99	Cocaine addiction_Homo sapiens_hsa05030	0.47956019
100	Insulin resistance_Homo sapiens_hsa04931	0.46642482

C11ORF68

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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