ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	9.94207383
2	motile cilium assembly (GO:0044458)	8.17953087
3	axoneme assembly (GO:0035082)	6.77580830
4	intraciliary transport (GO:0042073)	6.11944639
5	left/right pattern formation (GO:0060972)	5.77006246
6	regulation of cilium movement (GO:0003352)	5.70450580
7	cilium organization (GO:0044782)	5.25857473
8	cilium assembly (GO:0042384)	5.14672082
9	protein localization to cilium (GO:0061512)	4.86016242
10	ventricular system development (GO:0021591)	4.78306033
11	left/right axis specification (GO:0070986)	4.67548700
12	cilium morphogenesis (GO:0060271)	4.62195463
13	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.96924222
14	microtubule bundle formation (GO:0001578)	3.93409268
15	cellular component assembly involved in morphogenesis (GO:0010927)	3.93282422
16	nonmotile primary cilium assembly (GO:0035058)	3.87560795
17	nucleoside diphosphate phosphorylation (GO:0006165)	3.84132696
18	primary alcohol catabolic process (GO:0034310)	3.80006692
19	vitamin transmembrane transport (GO:0035461)	3.60772457
20	GTP biosynthetic process (GO:0006183)	3.57964857
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.55319079
22	ATP synthesis coupled proton transport (GO:0015986)	3.47837823
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.47837823
24	regulation of microtubule-based movement (GO:0060632)	3.38285771
25	centriole assembly (GO:0098534)	3.34145627
26	cell projection assembly (GO:0030031)	3.30777128
27	negative regulation of T cell differentiation in thymus (GO:0033085)	3.30575770
28	diterpenoid biosynthetic process (GO:0016102)	3.26975406
29	microtubule-based movement (GO:0007018)	3.26524908
30	smoothened signaling pathway (GO:0007224)	3.22092339
31	determination of left/right symmetry (GO:0007368)	3.20966755
32	terpenoid biosynthetic process (GO:0016114)	3.18416769
33	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.18181658
34	glutathione derivative biosynthetic process (GO:1901687)	3.15817274
35	glutathione derivative metabolic process (GO:1901685)	3.15817274
36	protein complex biogenesis (GO:0070271)	3.11537893
37	centriole replication (GO:0007099)	3.11135942
38	determination of bilateral symmetry (GO:0009855)	3.04472887
39	sperm motility (GO:0030317)	3.03669399
40	mitochondrial respiratory chain complex assembly (GO:0033108)	2.99736019
41	specification of symmetry (GO:0009799)	2.98195065
42	ethanol metabolic process (GO:0006067)	2.95867758
43	electron transport chain (GO:0022900)	2.91606056
44	UTP biosynthetic process (GO:0006228)	2.91472203
45	cornea development in camera-type eye (GO:0061303)	2.88381824
46	aldehyde catabolic process (GO:0046185)	2.87063838
47	one-carbon compound transport (GO:0019755)	2.86510261
48	microtubule depolymerization (GO:0007019)	2.84163036
49	respiratory electron transport chain (GO:0022904)	2.81083234
50	retinoic acid metabolic process (GO:0042573)	2.79281181
51	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.78754369
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.77896723
53	NADH dehydrogenase complex assembly (GO:0010257)	2.77896723
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.77896723
55	proteasome assembly (GO:0043248)	2.77748612
56	protein polyglutamylation (GO:0018095)	2.77444688
57	lateral sprouting from an epithelium (GO:0060601)	2.75638971
58	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.73924299
59	response to xenobiotic stimulus (GO:0009410)	2.73561931
60	UTP metabolic process (GO:0046051)	2.71285585
61	neural tube formation (GO:0001841)	2.71048529
62	male meiosis I (GO:0007141)	2.70698076
63	behavioral response to nicotine (GO:0035095)	2.70310956
64	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.67884865
65	preassembly of GPI anchor in ER membrane (GO:0016254)	2.64730695
66	microtubule polymerization or depolymerization (GO:0031109)	2.62384284
67	photoreceptor cell maintenance (GO:0045494)	2.59726268
68	cellular ketone body metabolic process (GO:0046950)	2.57934157
69	retinal rod cell development (GO:0046548)	2.54851573
70	establishment of tissue polarity (GO:0007164)	2.54523526
71	establishment of planar polarity (GO:0001736)	2.54523526
72	retinol metabolic process (GO:0042572)	2.52478632
73	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.49975112
74	nucleoside triphosphate biosynthetic process (GO:0009142)	2.48808437
75	ATP biosynthetic process (GO:0006754)	2.47385176
76	lung epithelium development (GO:0060428)	2.43862857
77	C-terminal protein lipidation (GO:0006501)	2.42551270
78	respiratory chain complex IV assembly (GO:0008535)	2.40404391
79	C-terminal protein amino acid modification (GO:0018410)	2.39756531
80	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.38882358
81	establishment of monopolar cell polarity (GO:0061162)	2.38882358
82	proton transport (GO:0015992)	2.37930457
83	platelet dense granule organization (GO:0060155)	2.37773171
84	ubiquinone biosynthetic process (GO:0006744)	2.37550966
85	CTP biosynthetic process (GO:0006241)	2.35850565
86	CTP metabolic process (GO:0046036)	2.35850565
87	establishment of apical/basal cell polarity (GO:0035089)	2.35013569
88	hydrogen transport (GO:0006818)	2.33348118
89	exogenous drug catabolic process (GO:0042738)	2.33184562
90	hydrogen ion transmembrane transport (GO:1902600)	2.32295628
91	protein-cofactor linkage (GO:0018065)	2.32192131
92	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.30422440
93	nucleotide phosphorylation (GO:0046939)	2.28926854
94	organelle assembly (GO:0070925)	2.28804992
95	spinal cord motor neuron differentiation (GO:0021522)	2.28747234
96	water-soluble vitamin biosynthetic process (GO:0042364)	2.28426718
97	axonemal dynein complex assembly (GO:0070286)	13.2247110
98	cilium movement (GO:0003341)	10.5895847
99	cilium or flagellum-dependent cell motility (GO:0001539)	10.5689645
100	epithelial cilium movement (GO:0003351)	10.0717428

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.10212571
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.98355733
3	VDR_22108803_ChIP-Seq_LS180_Human	2.91122689
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75208391
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.60325036
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.28927453
7	FUS_26573619_Chip-Seq_HEK293_Human	2.26758398
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.15318257
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14096960
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.12644706
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09610376
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07028529
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.05907268
14	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02481748
15	TAF15_26573619_Chip-Seq_HEK293_Human	1.99408374
16	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.98675320
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95459699
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.88064043
19	EWS_26573619_Chip-Seq_HEK293_Human	1.83516157
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.83094018
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69245259
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68466239
23	P300_19829295_ChIP-Seq_ESCs_Human	1.68320834
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.56767518
25	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55064078
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.53830061
27	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.52023705
28	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51629604
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.51586896
30	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48685375
31	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.44733561
32	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.44733561
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39795102
34	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.39345472
35	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.38489033
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.38162211
37	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.34127381
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.33438543
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32398406
40	PHF8_20622853_ChIP-Seq_HELA_Human	1.32197514
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31818334
42	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.31802956
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30867404
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.29050620
45	STAT3_23295773_ChIP-Seq_U87_Human	1.28075914
46	AR_25329375_ChIP-Seq_VCAP_Human	1.27542209
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26475357
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26065699
49	EZH2_22144423_ChIP-Seq_EOC_Human	1.25857935
50	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25843483
51	ELK1_19687146_ChIP-ChIP_HELA_Human	1.25692687
52	AR_20517297_ChIP-Seq_VCAP_Human	1.25104417
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.24190635
54	* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.21848909
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.20376047
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20376047
57	ETV1_20927104_ChIP-Seq_GIST48_Human	1.20301041
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.19633721
59	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18403447
60	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.16934547
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16881146
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16881146
63	TBL1_22424771_ChIP-Seq_293T_Human	1.15856472
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.15561684
65	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.14036925
66	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.13758261
67	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.12594318
68	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.12241365
69	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.10562912
70	NFYB_21822215_ChIP-Seq_K562_Human	1.10114937
71	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09690570
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08414784
73	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.08386310
74	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08084869
75	NFYA_21822215_ChIP-Seq_K562_Human	1.08079457
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.07245331
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07045653
78	TCF4_23295773_ChIP-Seq_U87_Human	1.05346470
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05023685
80	NCOR_22424771_ChIP-Seq_293T_Human	1.04824575
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.02042552
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02041185
83	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01475142
84	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01407943
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01323239
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.01258579
87	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00216985
88	* GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96457424
89	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.96417635
90	VDR_23849224_ChIP-Seq_CD4+_Human	0.96190819
91	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96007808
92	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.95655181
93	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.95652383
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.95469819
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94698787
96	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.94584707
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.94458254
98	TP53_18474530_ChIP-ChIP_U2OS_Human	0.94019516
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93987840
100	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93984165

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	4.25728726
2	MP0008875_abnormal_xenobiotic_pharmacok	3.88667151
3	MP0004133_heterotaxia	2.84858822
4	MP0000566_synostosis	2.43233164
5	MP0001984_abnormal_olfaction	2.41501522
6	MP0004043_abnormal_pH_regulation	2.41341817
7	MP0003878_abnormal_ear_physiology	2.22429544
8	MP0005377_hearing/vestibular/ear_phenot	2.22429544
9	MP0008789_abnormal_olfactory_epithelium	2.12703228
10	MP0002282_abnormal_trachea_morphology	2.03735982
11	MP0010030_abnormal_orbit_morphology	1.98859994
12	MP0003136_yellow_coat_color	1.85233330
13	MP0001485_abnormal_pinna_reflex	1.80728736
14	MP0002277_abnormal_respiratory_mucosa	1.80629148
15	MP0002638_abnormal_pupillary_reflex	1.79021689
16	MP0004019_abnormal_vitamin_homeostasis	1.76190251
17	MP0003880_abnormal_central_pattern	1.73394415
18	MP0005551_abnormal_eye_electrophysiolog	1.73258912
19	MP0000427_abnormal_hair_cycle	1.73101711
20	MP0003011_delayed_dark_adaptation	1.69951529
21	MP0005646_abnormal_pituitary_gland	1.68596813
22	MP0002160_abnormal_reproductive_system	1.68552256
23	MP0006072_abnormal_retinal_apoptosis	1.64812333
24	MP0000383_abnormal_hair_follicle	1.64125899
25	MP0005253_abnormal_eye_physiology	1.62166513
26	MP0001968_abnormal_touch/_nociception	1.61005295
27	MP0009046_muscle_twitch	1.60602573
28	MP0009780_abnormal_chondrocyte_physiolo	1.59710442
29	MP0005623_abnormal_meninges_morphology	1.56828417
30	MP0002102_abnormal_ear_morphology	1.56730396
31	MP0003195_calcinosis	1.54647155
32	MP0002876_abnormal_thyroid_physiology	1.50113722
33	MP0002736_abnormal_nociception_after	1.50100055
34	MP0003806_abnormal_nucleotide_metabolis	1.49494923
35	MP0001293_anophthalmia	1.46652393
36	MP0002735_abnormal_chemical_nociception	1.45810871
37	MP0001346_abnormal_lacrimal_gland	1.45313172
38	MP0000631_abnormal_neuroendocrine_gland	1.43741690
39	MP0003718_maternal_effect	1.34666574
40	MP0000647_abnormal_sebaceous_gland	1.34616690
41	MP0002938_white_spotting	1.33121029
42	MP0002837_dystrophic_cardiac_calcinosis	1.31677646
43	MP0003937_abnormal_limbs/digits/tail_de	1.30917629
44	MP0002909_abnormal_adrenal_gland	1.30422339
45	MP0004885_abnormal_endolymph	1.29250771
46	MP0000026_abnormal_inner_ear	1.26967874
47	MP0009745_abnormal_behavioral_response	1.26335904
48	MP0005394_taste/olfaction_phenotype	1.24950548
49	MP0005499_abnormal_olfactory_system	1.24950548
50	MP0006292_abnormal_olfactory_placode	1.20227352
51	MP0002234_abnormal_pharynx_morphology	1.20137450
52	MP0008877_abnormal_DNA_methylation	1.19095733
53	MP0001905_abnormal_dopamine_level	1.18849001
54	MP0002132_abnormal_respiratory_system	1.18781581
55	MP0000049_abnormal_middle_ear	1.17261928
56	MP0003938_abnormal_ear_development	1.15803595
57	MP0010386_abnormal_urinary_bladder	1.15759334
58	MP0005389_reproductive_system_phenotype	1.14327870
59	MP0002734_abnormal_mechanical_nocicepti	1.13149371
60	MP0002928_abnormal_bile_duct	1.12849916
61	MP0004142_abnormal_muscle_tone	1.12386455
62	MP0001529_abnormal_vocalization	1.09155978
63	MP0002233_abnormal_nose_morphology	1.07895946
64	MP0010678_abnormal_skin_adnexa	1.07288313
65	MP0001986_abnormal_taste_sensitivity	1.05468481
66	MP0001929_abnormal_gametogenesis	1.05222977
67	MP0008872_abnormal_physiological_respon	1.03737446
68	MP0003186_abnormal_redox_activity	1.02456462
69	MP0008058_abnormal_DNA_repair	1.01899641
70	MP0003698_abnormal_male_reproductive	1.01215183
71	MP0001970_abnormal_pain_threshold	0.99306072
72	MP0005084_abnormal_gallbladder_morpholo	0.98894405
73	MP0005391_vision/eye_phenotype	0.98616974
74	MP0005195_abnormal_posterior_eye	0.97664687
75	MP0009697_abnormal_copulation	0.96938456
76	MP0003119_abnormal_digestive_system	0.96639273
77	MP0002272_abnormal_nervous_system	0.95792812
78	MP0002557_abnormal_social/conspecific_i	0.95663748
79	MP0005645_abnormal_hypothalamus_physiol	0.95593822
80	MP0002210_abnormal_sex_determination	0.94577846
81	MP0001324_abnormal_eye_pigmentation	0.93384815
82	MP0002572_abnormal_emotion/affect_behav	0.93293639
83	MP0000778_abnormal_nervous_system	0.92831932
84	MP0001764_abnormal_homeostasis	0.91322475
85	MP0001486_abnormal_startle_reflex	0.90814378
86	MP0005395_other_phenotype	0.88369120
87	MP0003890_abnormal_embryonic-extraembry	0.87025536
88	MP0000653_abnormal_sex_gland	0.84035400
89	MP0003122_maternal_imprinting	0.83640647
90	MP0001145_abnormal_male_reproductive	0.82914762
91	MP0002752_abnormal_somatic_nervous	0.81265709
92	MP0001963_abnormal_hearing_physiology	0.80808308
93	MP0003252_abnormal_bile_duct	0.79809556
94	MP0000372_irregular_coat_pigmentation	0.78623266
95	MP0002733_abnormal_thermal_nociception	0.78608160
96	MP0005085_abnormal_gallbladder_physiolo	0.78464733
97	MP0001286_abnormal_eye_development	0.78436759
98	MP0005636_abnormal_mineral_homeostasis	0.75569964
99	MP0000569_abnormal_digit_pigmentation	0.75215830
100	MP0005248_abnormal_Harderian_gland	0.74284602

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	9.90428965
2	Abnormal respiratory motile cilium physiology (HP:0012261)	8.59406260
3	Abnormal respiratory epithelium morphology (HP:0012253)	8.38033267
4	Abnormal respiratory motile cilium morphology (HP:0005938)	8.38033267
5	Abnormal ciliary motility (HP:0012262)	8.37413790
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	8.14475687
7	Absent/shortened dynein arms (HP:0200106)	8.14475687
8	Rhinitis (HP:0012384)	7.66756960
9	Chronic bronchitis (HP:0004469)	6.16333072
10	Bronchiectasis (HP:0002110)	5.22973567
11	Pancreatic fibrosis (HP:0100732)	4.80498627
12	True hermaphroditism (HP:0010459)	4.69741768
13	Pancreatic cysts (HP:0001737)	4.31148612
14	Nasal polyposis (HP:0100582)	4.14899684
15	Molar tooth sign on MRI (HP:0002419)	4.14694660
16	Abnormality of midbrain morphology (HP:0002418)	4.14694660
17	Nephronophthisis (HP:0000090)	4.08702347
18	Occipital encephalocele (HP:0002085)	3.95261389
19	Cystic liver disease (HP:0006706)	3.38989873
20	Medial flaring of the eyebrow (HP:0010747)	3.36171986
21	Abnormality of the renal medulla (HP:0100957)	3.31359685
22	Chronic hepatic failure (HP:0100626)	3.28956618
23	Abnormality of the nasal mucosa (HP:0000433)	3.23909120
24	Postaxial foot polydactyly (HP:0001830)	2.95645118
25	Chronic sinusitis (HP:0011109)	2.91152912
26	Gait imbalance (HP:0002141)	2.90288628
27	Anencephaly (HP:0002323)	2.90199507
28	Bronchitis (HP:0012387)	2.90159073
29	Congenital primary aphakia (HP:0007707)	2.87829392
30	Recurrent sinusitis (HP:0011108)	2.86118273
31	Sclerocornea (HP:0000647)	2.79732840
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.77992203
33	Tubular atrophy (HP:0000092)	2.77523326
34	Infertility (HP:0000789)	2.70128699
35	Congenital hepatic fibrosis (HP:0002612)	2.68244350
36	Nephrogenic diabetes insipidus (HP:0009806)	2.64610223
37	Male pseudohermaphroditism (HP:0000037)	2.44018995
38	Furrowed tongue (HP:0000221)	2.42611313
39	Abnormality of the renal cortex (HP:0011035)	2.34227729
40	Oculomotor apraxia (HP:0000657)	2.32078940
41	Genital tract atresia (HP:0001827)	2.27991572
42	Postaxial hand polydactyly (HP:0001162)	2.26675693
43	Vaginal atresia (HP:0000148)	2.25179256
44	Recurrent otitis media (HP:0000403)	2.16763248
45	Polydipsia (HP:0001959)	2.14331961
46	Abnormal drinking behavior (HP:0030082)	2.14331961
47	Preaxial hand polydactyly (HP:0001177)	2.12308527
48	Tubulointerstitial nephritis (HP:0001970)	2.09934084
49	Acute necrotizing encephalopathy (HP:0006965)	2.03609270
50	Poor coordination (HP:0002370)	1.98024244
51	Bile duct proliferation (HP:0001408)	1.96905778
52	Abnormal biliary tract physiology (HP:0012439)	1.96905778
53	Hyperactive renin-angiotensin system (HP:0000841)	1.94844436
54	Male infertility (HP:0003251)	1.91345620
55	Mitochondrial inheritance (HP:0001427)	1.91091797
56	Chronic otitis media (HP:0000389)	1.87499916
57	Abnormal mitochondria in muscle tissue (HP:0008316)	1.86502842
58	Anophthalmia (HP:0000528)	1.83712061
59	Acute encephalopathy (HP:0006846)	1.82075154
60	Median cleft lip (HP:0000161)	1.81209513
61	Atelectasis (HP:0100750)	1.76702652
62	Abnormality of macular pigmentation (HP:0008002)	1.73151213
63	Progressive macrocephaly (HP:0004481)	1.72188111
64	Aganglionic megacolon (HP:0002251)	1.69533683
65	Increased CSF lactate (HP:0002490)	1.61885522
66	Nephropathy (HP:0000112)	1.61085315
67	Abnormal rod and cone electroretinograms (HP:0008323)	1.60813560
68	Stage 5 chronic kidney disease (HP:0003774)	1.60774025
69	3-Methylglutaconic aciduria (HP:0003535)	1.60318599
70	Polyuria (HP:0000103)	1.60176940
71	Supernumerary spleens (HP:0009799)	1.57307354
72	Congenital stationary night blindness (HP:0007642)	1.54998665
73	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.54743693
74	Retinitis pigmentosa (HP:0000510)	1.53321672
75	Prominent nasal bridge (HP:0000426)	1.53158746
76	Decreased circulating renin level (HP:0003351)	1.52941981
77	Aplasia/hypoplasia of the uterus (HP:0008684)	1.50160487
78	Narrow forehead (HP:0000341)	1.50156776
79	Aplasia/Hypoplasia of the lens (HP:0008063)	1.49820702
80	Renal salt wasting (HP:0000127)	1.48466267
81	Esophageal atresia (HP:0002032)	1.47140827
82	Multicystic kidney dysplasia (HP:0000003)	1.44480095
83	Tubulointerstitial abnormality (HP:0001969)	1.43503125
84	Congenital, generalized hypertrichosis (HP:0004540)	1.42648982
85	Increased hepatocellular lipid droplets (HP:0006565)	1.41992953
86	Lipid accumulation in hepatocytes (HP:0006561)	1.40027483
87	Holoprosencephaly (HP:0001360)	1.38876534
88	Bell-shaped thorax (HP:0001591)	1.38796031
89	Decreased central vision (HP:0007663)	1.37045609
90	Asplenia (HP:0001746)	1.35242691
91	Hepatocellular necrosis (HP:0001404)	1.35133274
92	Broad foot (HP:0001769)	1.35010145
93	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.34136646
94	Oligodactyly (hands) (HP:0001180)	1.33694058
95	Type II lissencephaly (HP:0007260)	1.32948997
96	Highly arched eyebrow (HP:0002553)	1.32864578
97	Renal dysplasia (HP:0000110)	1.32555691
98	Oligohydramnios (HP:0001562)	1.29303731
99	Pendular nystagmus (HP:0012043)	1.28641634
100	Facial cleft (HP:0002006)	1.27847384

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	5.62700198
2	PNCK	3.19481324
3	MST4	2.94390158
4	NME1	2.83943352
5	FRK	2.72011925
6	EPHA2	2.31751802
7	MAP4K2	2.26422686
8	ZAK	2.20278706
9	INSRR	2.18327826
10	WNK3	2.14826555
11	TLK1	2.10321118
12	STK16	2.07713547
13	CASK	1.98308342
14	OXSR1	1.93873118
15	BMPR1B	1.83298878
16	GRK1	1.82936234
17	WNK4	1.70774282
18	ADRBK2	1.68688044
19	STK38L	1.67640101
20	MAP3K12	1.63762532
21	PTK2B	1.56604297
22	MAPK13	1.40628308
23	VRK2	1.33789543
24	WEE1	1.33668359
25	BCR	1.26894497
26	MAP3K4	1.22784160
27	STK39	1.21196203
28	VRK1	1.19007871
29	MAPKAPK3	1.18866356
30	TTK	1.17345216
31	PINK1	1.15652704
32	MET	1.14039671
33	LATS1	1.11490904
34	EPHA3	1.11141261
35	EPHA4	1.08605902
36	NUAK1	1.05453286
37	CDK19	1.04946704
38	TNIK	1.02934703
39	CSNK1G2	0.99164418
40	MAP2K7	0.97727855
41	MAPKAPK5	0.97051356
42	STK24	0.93550755
43	DYRK2	0.92894721
44	BRSK2	0.91071484
45	PAK3	0.90140050
46	EPHB2	0.86669502
47	PRKCE	0.85689600
48	ACVR1B	0.85135550
49	CSNK1G1	0.84058183
50	PLK2	0.79317967
51	MAP3K2	0.78446863
52	DYRK3	0.78289298
53	PBK	0.77268286
54	PRKCI	0.76893326
55	CSNK1G3	0.75648052
56	TSSK6	0.75592619
57	PHKG1	0.74627008
58	PHKG2	0.74627008
59	ERBB3	0.73844693
60	PLK3	0.71523371
61	ADRBK1	0.70632172
62	PLK1	0.69471276
63	BUB1	0.69395486
64	BCKDK	0.67807473
65	MYLK	0.67533004
66	TRIM28	0.66870257
67	TAF1	0.65051040
68	MARK1	0.64974634
69	SRPK1	0.64883886
70	PLK4	0.64148736
71	STK3	0.62344742
72	MUSK	0.60353986
73	FGFR2	0.58863361
74	MKNK2	0.58094205
75	PRKCG	0.57537820
76	CSNK1A1L	0.56955071
77	NTRK3	0.56912038
78	IRAK1	0.55400678
79	CCNB1	0.52871739
80	CAMK2A	0.52322446
81	PRKD3	0.50989499
82	RPS6KA5	0.50127420
83	LIMK1	0.49438571
84	TGFBR1	0.49376381
85	FER	0.47373146
86	CAMKK2	0.46370469
87	MKNK1	0.45649375
88	NLK	0.44135685
89	CHEK2	0.42999242
90	PKN1	0.37761085
91	STK38	0.34767479
92	EIF2AK1	0.33754477
93	PRKACA	0.31572903
94	ABL2	0.31148720
95	CAMK2G	0.30587812
96	EPHB1	0.30430976
97	NTRK2	0.30059883
98	ERBB2	0.29592473
99	AURKA	0.25835758
100	CSNK1A1	0.25538116

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.32350791
2	Huntingtons disease_Homo sapiens_hsa05016	2.92739176
3	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.85985917
4	Parkinsons disease_Homo sapiens_hsa05012	2.59944318
5	Chemical carcinogenesis_Homo sapiens_hsa05204	2.55081234
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.42468343
7	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.40725385
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37911758
9	Proteasome_Homo sapiens_hsa03050	2.35661456
10	Protein export_Homo sapiens_hsa03060	2.18074210
11	Tyrosine metabolism_Homo sapiens_hsa00350	2.03582310
12	Phenylalanine metabolism_Homo sapiens_hsa00360	1.87075023
13	RNA polymerase_Homo sapiens_hsa03020	1.81862124
14	Alzheimers disease_Homo sapiens_hsa05010	1.76315996
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75487790
16	Glutathione metabolism_Homo sapiens_hsa00480	1.74548899
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.70093646
18	Histidine metabolism_Homo sapiens_hsa00340	1.68745822
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.64147673
20	Phototransduction_Homo sapiens_hsa04744	1.61304760
21	Caffeine metabolism_Homo sapiens_hsa00232	1.60106662
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.55465644
23	Nicotine addiction_Homo sapiens_hsa05033	1.51467872
24	Retinol metabolism_Homo sapiens_hsa00830	1.49183968
25	Homologous recombination_Homo sapiens_hsa03440	1.49179110
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.48359670
27	Peroxisome_Homo sapiens_hsa04146	1.45795356
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.45067955
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.41966423
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37924308
31	Ribosome_Homo sapiens_hsa03010	1.37532204
32	Propanoate metabolism_Homo sapiens_hsa00640	1.34412441
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.32934826
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.32910149
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32012618
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.30610412
37	Butanoate metabolism_Homo sapiens_hsa00650	1.29396224
38	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29141315
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.26023708
40	Sulfur metabolism_Homo sapiens_hsa00920	1.25968439
41	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.17894380
42	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.10797000
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.10608467
44	Basal transcription factors_Homo sapiens_hsa03022	1.09764749
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.08874778
46	Nucleotide excision repair_Homo sapiens_hsa03420	1.08796924
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07499725
48	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06582093
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.05753769
50	Folate biosynthesis_Homo sapiens_hsa00790	1.05438000
51	Tryptophan metabolism_Homo sapiens_hsa00380	0.99803837
52	Purine metabolism_Homo sapiens_hsa00230	0.98470883
53	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.94648513
54	Metabolic pathways_Homo sapiens_hsa01100	0.94471217
55	Selenocompound metabolism_Homo sapiens_hsa00450	0.93685809
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.89496153
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.89420331
58	Mismatch repair_Homo sapiens_hsa03430	0.87754639
59	Sulfur relay system_Homo sapiens_hsa04122	0.83635725
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82148883
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.81693488
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79208202
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78885645
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.78073536
65	Taste transduction_Homo sapiens_hsa04742	0.76961484
66	One carbon pool by folate_Homo sapiens_hsa00670	0.75913279
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.75407645
68	Steroid biosynthesis_Homo sapiens_hsa00100	0.74050234
69	Fatty acid degradation_Homo sapiens_hsa00071	0.73934379
70	RNA degradation_Homo sapiens_hsa03018	0.71275276
71	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.69773755
72	ABC transporters_Homo sapiens_hsa02010	0.69137379
73	Fatty acid elongation_Homo sapiens_hsa00062	0.69054579
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.64263724
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.63400930
76	Circadian rhythm_Homo sapiens_hsa04710	0.62058164
77	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61413261
78	Regulation of autophagy_Homo sapiens_hsa04140	0.60385448
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.59899857
80	Olfactory transduction_Homo sapiens_hsa04740	0.58430569
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53508481
82	Mineral absorption_Homo sapiens_hsa04978	0.53041427
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.49444056
84	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.47321887
85	Cocaine addiction_Homo sapiens_hsa05030	0.46667625
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.45864875
87	GABAergic synapse_Homo sapiens_hsa04727	0.43051545
88	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42205190
89	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40932738
90	Salivary secretion_Homo sapiens_hsa04970	0.40796039
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40717111
92	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.37829236
93	Hippo signaling pathway_Homo sapiens_hsa04390	0.37647146
94	Morphine addiction_Homo sapiens_hsa05032	0.37440314
95	Tight junction_Homo sapiens_hsa04530	0.35552643
96	Serotonergic synapse_Homo sapiens_hsa04726	0.35414892
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.31378551
98	Glutamatergic synapse_Homo sapiens_hsa04724	0.28871425
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27101180
100	Spliceosome_Homo sapiens_hsa03040	0.25672161

C11ORF70

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »