C11ORF74

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.88250500
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.22824528
3ATP synthesis coupled proton transport (GO:0015986)5.22824528
4epithelial cilium movement (GO:0003351)5.17631818
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.86872778
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.76409148
7axonemal dynein complex assembly (GO:0070286)4.66091375
8ribosomal small subunit assembly (GO:0000028)4.62228845
9cilium movement (GO:0003341)4.51596709
10viral transcription (GO:0019083)4.30204421
11respiratory electron transport chain (GO:0022904)4.26516437
12translational termination (GO:0006415)4.21323047
13electron transport chain (GO:0022900)4.19179744
14establishment of protein localization to mitochondrial membrane (GO:0090151)4.15008694
15cotranslational protein targeting to membrane (GO:0006613)3.92583522
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.92520569
17chaperone-mediated protein transport (GO:0072321)3.91321462
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.90060992
19NADH dehydrogenase complex assembly (GO:0010257)3.90060992
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.90060992
21intraciliary transport (GO:0042073)3.88842965
22protein complex biogenesis (GO:0070271)3.87059986
23protein neddylation (GO:0045116)3.83056086
24protein targeting to ER (GO:0045047)3.81385967
25sequestering of actin monomers (GO:0042989)3.71218797
26establishment of protein localization to endoplasmic reticulum (GO:0072599)3.69482951
27protein localization to endoplasmic reticulum (GO:0070972)3.60113005
28mitochondrial respiratory chain complex assembly (GO:0033108)3.55435465
29nonmotile primary cilium assembly (GO:0035058)3.49856869
30translational elongation (GO:0006414)3.47505413
31chromatin remodeling at centromere (GO:0031055)3.31529829
32cellular protein complex disassembly (GO:0043624)3.28967398
33CENP-A containing nucleosome assembly (GO:0034080)3.19495382
34cilium or flagellum-dependent cell motility (GO:0001539)3.18585398
35axoneme assembly (GO:0035082)3.17566767
36maturation of SSU-rRNA (GO:0030490)3.16155000
37viral life cycle (GO:0019058)3.13691142
38translational initiation (GO:0006413)3.13108767
39nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.10142657
40regulation of cilium movement (GO:0003352)3.09347083
41proteasome assembly (GO:0043248)3.09283219
42organelle disassembly (GO:1903008)3.07297662
43ribosomal large subunit biogenesis (GO:0042273)3.06343107
44respiratory chain complex IV assembly (GO:0008535)3.05236034
45aldehyde catabolic process (GO:0046185)3.02345210
46GTP biosynthetic process (GO:0006183)3.01070074
47purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97789837
48ATP biosynthetic process (GO:0006754)2.96753972
49purine nucleoside triphosphate biosynthetic process (GO:0009145)2.95774877
50protein-cofactor linkage (GO:0018065)2.92722338
51cilium organization (GO:0044782)2.91716048
52cullin deneddylation (GO:0010388)2.91338980
53cilium morphogenesis (GO:0060271)2.90630291
54DNA damage response, detection of DNA damage (GO:0042769)2.90626211
55ribosomal small subunit biogenesis (GO:0042274)2.90246099
56hydrogen ion transmembrane transport (GO:1902600)2.89906993
57behavioral response to nicotine (GO:0035095)2.88837123
58cilium assembly (GO:0042384)2.87626604
59platelet dense granule organization (GO:0060155)2.86976716
60regulation of mitochondrial translation (GO:0070129)2.85206820
61oxidative phosphorylation (GO:0006119)2.83547423
62motile cilium assembly (GO:0044458)2.83529649
63protein localization to cilium (GO:0061512)2.79876829
64protein complex disassembly (GO:0043241)2.78817760
65neuron fate determination (GO:0048664)2.78438043
66somite development (GO:0061053)2.75269701
67macromolecular complex disassembly (GO:0032984)2.74472545
68inner mitochondrial membrane organization (GO:0007007)2.73596544
69translation (GO:0006412)2.73124178
70water-soluble vitamin biosynthetic process (GO:0042364)2.71858434
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71443878
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71443878
73cytochrome complex assembly (GO:0017004)2.69961905
74establishment of integrated proviral latency (GO:0075713)2.67176473
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65847755
76left/right axis specification (GO:0070986)2.65416590
77response to pheromone (GO:0019236)2.64232189
78microtubule depolymerization (GO:0007019)2.63994581
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.63465268
80proton transport (GO:0015992)2.63068510
81termination of RNA polymerase III transcription (GO:0006386)2.62242512
82transcription elongation from RNA polymerase III promoter (GO:0006385)2.62242512
83protein deneddylation (GO:0000338)2.62083046
84substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.61905810
85substrate-independent telencephalic tangential migration (GO:0021826)2.61905810
86centriole replication (GO:0007099)2.61165841
87histone exchange (GO:0043486)2.59968759
88left/right pattern formation (GO:0060972)2.59735187
89hydrogen transport (GO:0006818)2.59474094
90intracellular protein transmembrane import (GO:0044743)2.59131526
91nucleoside triphosphate biosynthetic process (GO:0009142)2.54614432
92protein targeting to membrane (GO:0006612)2.54162458
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54027466
94pyrimidine nucleobase catabolic process (GO:0006208)2.53275658
95otic vesicle formation (GO:0030916)2.52868777
96ubiquinone biosynthetic process (GO:0006744)2.52004324
97UTP biosynthetic process (GO:0006228)2.51835071
98nucleoside diphosphate phosphorylation (GO:0006165)2.45481144
99ubiquinone metabolic process (GO:0006743)2.44628299
100nuclear-transcribed mRNA catabolic process (GO:0000956)2.43873915

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48755089
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.35261765
3EZH2_22144423_ChIP-Seq_EOC_Human3.15500159
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.06578704
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99107303
6* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74197529
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.65399912
8VDR_22108803_ChIP-Seq_LS180_Human2.57035135
9ZNF274_21170338_ChIP-Seq_K562_Hela2.49169267
10FUS_26573619_Chip-Seq_HEK293_Human2.43196059
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37970299
12EWS_26573619_Chip-Seq_HEK293_Human2.25942511
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21938244
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17193401
15ELK1_19687146_ChIP-ChIP_HELA_Human2.17151038
16IGF1R_20145208_ChIP-Seq_DFB_Human2.14153959
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08567679
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05063972
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04752582
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96574218
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.95111756
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92889981
23TAF15_26573619_Chip-Seq_HEK293_Human1.91234431
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87127119
25GBX2_23144817_ChIP-Seq_PC3_Human1.78337593
26MYC_18940864_ChIP-ChIP_HL60_Human1.73569038
27P300_19829295_ChIP-Seq_ESCs_Human1.73081916
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68656183
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67563908
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.64205199
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62355695
32POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59584120
33VDR_23849224_ChIP-Seq_CD4+_Human1.59380981
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59378052
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.57345241
36RNF2_27304074_Chip-Seq_NSC_Mouse1.56127561
37SALL1_21062744_ChIP-ChIP_HESCs_Human1.54808080
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54011691
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49394377
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48708619
41MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46820892
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.43546553
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.39144097
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32377982
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.31815525
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30156012
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26058208
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24833568
49IRF1_19129219_ChIP-ChIP_H3396_Human1.23948580
50TTF2_22483619_ChIP-Seq_HELA_Human1.23734939
51* FOXP3_21729870_ChIP-Seq_TREG_Human1.19815853
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19650310
53TP53_22573176_ChIP-Seq_HFKS_Human1.19571634
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18248335
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.18145837
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16488194
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15127131
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13663044
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.12777031
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.12139557
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11424773
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10541581
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.08398556
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08128523
65CBP_20019798_ChIP-Seq_JUKART_Human1.08128523
66GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06582322
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06094210
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06043283
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05897817
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05897817
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05267124
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.05241361
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.04619226
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04534352
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04378205
76ER_23166858_ChIP-Seq_MCF-7_Human1.03912491
77SMAD4_21799915_ChIP-Seq_A2780_Human1.03302112
78BCAT_22108803_ChIP-Seq_LS180_Human1.03266707
79SOX2_19829295_ChIP-Seq_ESCs_Human1.02492144
80NANOG_19829295_ChIP-Seq_ESCs_Human1.02492144
81TCF4_22108803_ChIP-Seq_LS180_Human1.01860773
82E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01813642
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00222911
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99829310
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.99734798
86SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98809548
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97738671
88MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97558336
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97549237
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97299421
91TAL1_26923725_Chip-Seq_HPCs_Mouse0.97202986
92AR_25329375_ChIP-Seq_VCAP_Human0.96926445
93KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96661449
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95534192
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.93117477
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93109680
97GABP_19822575_ChIP-Seq_HepG2_Human0.92847985
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92747387
99RUNX2_22187159_ChIP-Seq_PCA_Human0.91733626
100REST_21632747_ChIP-Seq_MESCs_Mouse0.89568318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode2.96528599
2MP0009379_abnormal_foot_pigmentation2.70892057
3MP0008789_abnormal_olfactory_epithelium2.66191122
4MP0010030_abnormal_orbit_morphology2.62408989
5MP0003136_yellow_coat_color2.52251635
6MP0003122_maternal_imprinting2.43449890
7MP0001529_abnormal_vocalization2.40958118
8MP0005394_taste/olfaction_phenotype2.23498875
9MP0005499_abnormal_olfactory_system2.23498875
10MP0002938_white_spotting2.18317852
11MP0006072_abnormal_retinal_apoptosis2.08111728
12MP0008877_abnormal_DNA_methylation2.03445529
13MP0000566_synostosis2.00870679
14MP0001293_anophthalmia2.00382749
15MP0003880_abnormal_central_pattern1.95632420
16MP0004133_heterotaxia1.90273235
17MP0005084_abnormal_gallbladder_morpholo1.87146260
18MP0002102_abnormal_ear_morphology1.84300706
19MP0002653_abnormal_ependyma_morphology1.83607673
20MP0001984_abnormal_olfaction1.83215405
21MP0006276_abnormal_autonomic_nervous1.82254752
22MP0003121_genomic_imprinting1.81195203
23MP0004142_abnormal_muscle_tone1.80372759
24MP0008058_abnormal_DNA_repair1.76489447
25MP0003011_delayed_dark_adaptation1.71103167
26MP0003890_abnormal_embryonic-extraembry1.69887175
27MP0000778_abnormal_nervous_system1.65493332
28MP0002638_abnormal_pupillary_reflex1.62908313
29MP0003718_maternal_effect1.62156551
30MP0002234_abnormal_pharynx_morphology1.55599818
31MP0003787_abnormal_imprinting1.55245647
32MP0000631_abnormal_neuroendocrine_gland1.52367389
33MP0008995_early_reproductive_senescence1.48293219
34MP0005551_abnormal_eye_electrophysiolog1.42069318
35MP0002233_abnormal_nose_morphology1.41998449
36MP0005253_abnormal_eye_physiology1.39140496
37MP0000049_abnormal_middle_ear1.32241566
38MP0005171_absent_coat_pigmentation1.31041809
39MP0003186_abnormal_redox_activity1.29896718
40MP0002736_abnormal_nociception_after1.29266025
41MP0004147_increased_porphyrin_level1.26141874
42MP0001968_abnormal_touch/_nociception1.25500159
43MP0002734_abnormal_mechanical_nocicepti1.24726052
44MP0003937_abnormal_limbs/digits/tail_de1.23903547
45MP0002735_abnormal_chemical_nociception1.22971878
46MP0002822_catalepsy1.21676396
47MP0002272_abnormal_nervous_system1.20480153
48MP0009697_abnormal_copulation1.19743372
49MP0002837_dystrophic_cardiac_calcinosis1.18812759
50MP0000372_irregular_coat_pigmentation1.16378861
51MP0001485_abnormal_pinna_reflex1.14672010
52MP0002751_abnormal_autonomic_nervous1.12925378
53MP0001486_abnormal_startle_reflex1.12470391
54MP0003567_abnormal_fetal_cardiomyocyte1.11238498
55MP0005423_abnormal_somatic_nervous1.11184455
56MP0001905_abnormal_dopamine_level1.10997631
57MP0010386_abnormal_urinary_bladder1.10862198
58MP0002282_abnormal_trachea_morphology1.09617533
59MP0001299_abnormal_eye_distance/1.09153528
60MP0003119_abnormal_digestive_system1.05883429
61MP0001286_abnormal_eye_development1.05096142
62MP0008875_abnormal_xenobiotic_pharmacok1.04374610
63MP0005195_abnormal_posterior_eye1.02053808
64MP0009046_muscle_twitch1.01921262
65MP0002752_abnormal_somatic_nervous1.01243928
66MP0009745_abnormal_behavioral_response1.00005782
67MP0002160_abnormal_reproductive_system0.99994891
68MP0005646_abnormal_pituitary_gland0.99627768
69MP0000026_abnormal_inner_ear0.99109139
70MP0002210_abnormal_sex_determination0.98857724
71MP0002184_abnormal_innervation0.97883363
72MP0000955_abnormal_spinal_cord0.95802574
73MP0002572_abnormal_emotion/affect_behav0.95000180
74MP0002557_abnormal_social/conspecific_i0.93471145
75MP0004885_abnormal_endolymph0.92001169
76MP0005391_vision/eye_phenotype0.91892124
77MP0001929_abnormal_gametogenesis0.87730585
78MP0002067_abnormal_sensory_capabilities0.87526354
79MP0004145_abnormal_muscle_electrophysio0.87248308
80MP0005187_abnormal_penis_morphology0.87244397
81MP0000653_abnormal_sex_gland0.87188634
82MP0003755_abnormal_palate_morphology0.86614422
83MP0001188_hyperpigmentation0.86608206
84MP0003698_abnormal_male_reproductive0.85945195
85MP0002277_abnormal_respiratory_mucosa0.84559393
86MP0001324_abnormal_eye_pigmentation0.84491553
87MP0003938_abnormal_ear_development0.84315481
88MP0001145_abnormal_male_reproductive0.83539588
89MP0002697_abnormal_eye_size0.82387365
90MP0002928_abnormal_bile_duct0.81966498
91MP0006035_abnormal_mitochondrial_morpho0.81875935
92MP0004215_abnormal_myocardial_fiber0.81518174
93MP0005248_abnormal_Harderian_gland0.81048998
94MP0000647_abnormal_sebaceous_gland0.80209895
95MP0003861_abnormal_nervous_system0.79423360
96MP0003137_abnormal_impulse_conducting0.79260594
97MP0010094_abnormal_chromosome_stability0.79061091
98MP0008932_abnormal_embryonic_tissue0.78301753
99MP0006036_abnormal_mitochondrial_physio0.77719892
100MP0001970_abnormal_pain_threshold0.77558880

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.65220623
2Abnormal respiratory motile cilium physiology (HP:0012261)4.16804651
3Acute necrotizing encephalopathy (HP:0006965)4.09350266
4Abnormal ciliary motility (HP:0012262)4.09265235
5Abnormal respiratory motile cilium morphology (HP:0005938)3.99792659
6Abnormal respiratory epithelium morphology (HP:0012253)3.99792659
7Pancreatic fibrosis (HP:0100732)3.92203552
8Abnormality of midbrain morphology (HP:0002418)3.80902346
9Molar tooth sign on MRI (HP:0002419)3.80902346
10True hermaphroditism (HP:0010459)3.75979402
11Absent/shortened dynein arms (HP:0200106)3.64972588
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.64972588
13Acute encephalopathy (HP:0006846)3.64374794
14Mitochondrial inheritance (HP:0001427)3.62973532
15Increased hepatocellular lipid droplets (HP:0006565)3.62404504
16Medial flaring of the eyebrow (HP:0010747)3.59533149
17Abnormal mitochondria in muscle tissue (HP:0008316)3.57168414
18Rhinitis (HP:0012384)3.55163048
19Pancreatic cysts (HP:0001737)3.49270206
20Nephronophthisis (HP:0000090)3.48469341
21Progressive macrocephaly (HP:0004481)3.42346183
22Lipid accumulation in hepatocytes (HP:0006561)3.30552743
23Increased CSF lactate (HP:0002490)3.23284083
24Abnormality of cells of the erythroid lineage (HP:0012130)3.19623870
25Gait imbalance (HP:0002141)3.12788556
26Hepatocellular necrosis (HP:0001404)3.10796346
27Abnormal number of erythroid precursors (HP:0012131)3.08519250
28Septo-optic dysplasia (HP:0100842)3.05475558
29Congenital primary aphakia (HP:0007707)3.04766658
30Nephrogenic diabetes insipidus (HP:0009806)2.91738169
31Hepatic necrosis (HP:0002605)2.91077501
32Renal Fanconi syndrome (HP:0001994)2.86624300
33Hyperglycinemia (HP:0002154)2.78029726
34Reticulocytopenia (HP:0001896)2.75572086
35Abnormality of the labia minora (HP:0012880)2.72058992
36Abnormality of the renal medulla (HP:0100957)2.66548946
37Cerebral edema (HP:0002181)2.64717034
38Colon cancer (HP:0003003)2.60007289
39Chronic bronchitis (HP:0004469)2.58811724
40Genital tract atresia (HP:0001827)2.57523823
41Congenital, generalized hypertrichosis (HP:0004540)2.56765000
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.56745784
43Sclerocornea (HP:0000647)2.56657765
44Supernumerary spleens (HP:0009799)2.55171055
45Vaginal atresia (HP:0000148)2.53840540
463-Methylglutaconic aciduria (HP:0003535)2.49461201
47Anencephaly (HP:0002323)2.48945142
48Cystic liver disease (HP:0006706)2.35559038
49Methylmalonic acidemia (HP:0002912)2.34061752
50Postaxial foot polydactyly (HP:0001830)2.28326247
51Macrocytic anemia (HP:0001972)2.27197502
52Stenosis of the external auditory canal (HP:0000402)2.26714467
53Absent septum pellucidum (HP:0001331)2.26165583
54Postaxial hand polydactyly (HP:0001162)2.22933034
55Occipital encephalocele (HP:0002085)2.19113866
56Congenital hepatic fibrosis (HP:0002612)2.14586580
57Increased intramyocellular lipid droplets (HP:0012240)2.13651064
58Chronic hepatic failure (HP:0100626)2.12458893
59Maternal diabetes (HP:0009800)2.10236383
60Myokymia (HP:0002411)2.10017199
61Exertional dyspnea (HP:0002875)2.08782241
62Poor coordination (HP:0002370)2.07817280
63Optic disc pallor (HP:0000543)2.06273166
64Optic nerve hypoplasia (HP:0000609)2.05151369
65Male pseudohermaphroditism (HP:0000037)2.03091060
66Lactic acidosis (HP:0003128)2.01889416
67Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00630016
68Abnormality of renal resorption (HP:0011038)1.96195993
69Respiratory failure (HP:0002878)1.95090287
70Preaxial hand polydactyly (HP:0001177)1.94421647
71Median cleft lip (HP:0000161)1.93866786
72Increased serum lactate (HP:0002151)1.91793896
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91220844
74Exercise intolerance (HP:0003546)1.90894119
75Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85746736
76Abnormality of alanine metabolism (HP:0010916)1.85746736
77Hyperalaninemia (HP:0003348)1.85746736
78Anophthalmia (HP:0000528)1.85443157
79Abnormality of the septum pellucidum (HP:0007375)1.85111692
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84817586
81Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84817586
82Abnormality of urine glucose concentration (HP:0011016)1.83514659
83Glycosuria (HP:0003076)1.83514659
84Hypothermia (HP:0002045)1.82445278
85Methylmalonic aciduria (HP:0012120)1.81680944
86Respiratory difficulties (HP:0002880)1.78532637
87Tubular atrophy (HP:0000092)1.78047554
88Tubulointerstitial nephritis (HP:0001970)1.77620856
89Concave nail (HP:0001598)1.76477956
90Leukodystrophy (HP:0002415)1.76268747
91Oligodactyly (hands) (HP:0001180)1.75691165
92Bronchiectasis (HP:0002110)1.72677975
93Oculomotor apraxia (HP:0000657)1.72327959
94Short tibia (HP:0005736)1.71835821
95Polyphagia (HP:0002591)1.67737828
96Lethargy (HP:0001254)1.67249829
97Triphalangeal thumb (HP:0001199)1.65483522
98Increased muscle lipid content (HP:0009058)1.65331623
99Hyperglycinuria (HP:0003108)1.65314998
100Bifid tongue (HP:0010297)1.65160770

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.47272218
2BMPR1B2.86890020
3VRK22.60778272
4WNK32.40475659
5CDC72.23614666
6ZAK2.14863442
7VRK12.08565281
8BCKDK2.05376286
9SRPK12.03355135
10NUAK11.94474823
11CASK1.90162400
12TNIK1.86403939
13MAP3K41.82057033
14BUB11.81731531
15DYRK21.78981507
16PLK31.74328723
17MAPK151.73823425
18MKNK11.64995416
19MAPK131.61671779
20PNCK1.54132303
21CDK191.53641731
22MARK11.52924367
23PINK11.50762973
24NME11.46021612
25TRIM281.43787637
26INSRR1.41608031
27MAP4K21.41034135
28TGFBR11.39433843
29TTK1.39319725
30PBK1.34998090
31BCR1.33695279
32DYRK31.33665512
33ERBB31.32901628
34GRK11.30885743
35EPHB21.30001998
36MAP2K71.27831117
37MKNK21.27680211
38TIE11.26763451
39CCNB11.24648896
40CDK81.19274274
41CSNK1G21.10526539
42EPHA41.09747978
43ADRBK21.09475856
44PLK21.08127598
45CSNK1G11.08038068
46WEE11.06300716
47PLK41.03168048
48BRSK21.02483581
49FRK1.01832591
50PLK11.00160095
51MST40.99619930
52CSNK1G30.98730294
53PRKCG0.95507700
54PASK0.92954259
55OBSCN0.92166281
56FGFR20.92113193
57TLK10.89696007
58UHMK10.88811129
59CHEK20.88717738
60LIMK10.85955651
61MINK10.82317679
62NTRK20.81459160
63TAF10.79819145
64PRKCE0.79099061
65NEK10.77721648
66MAP3K120.75621700
67CSNK1A1L0.71712550
68PAK30.69353008
69PDK20.64227249
70EIF2AK30.64103625
71AURKB0.63728701
72STK38L0.58938338
73CDK30.58651586
74CAMK2A0.58231976
75AURKA0.57971003
76OXSR10.54635364
77ATR0.54362551
78ACVR1B0.54004427
79TSSK60.50872393
80PHKG20.50808583
81PHKG10.50808583
82FLT30.50511332
83CSNK2A20.49365771
84PRKACA0.49082295
85CSNK2A10.48808835
86CSNK1A10.48551259
87PKN10.47094630
88CAMK10.46667471
89EIF2AK10.44474021
90STK240.43862245
91ADRBK10.42455832
92PRKACB0.42291271
93NEK20.41894518
94CSNK1E0.40849845
95BRSK10.40620395
96MAPKAPK50.40176657
97WNK40.39874958
98PRKG10.39779793
99MAP2K40.39471531
100DYRK1A0.38980329

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.36718014
2Ribosome_Homo sapiens_hsa030103.99403944
3Parkinsons disease_Homo sapiens_hsa050123.81994709
4Protein export_Homo sapiens_hsa030603.03429253
5Huntingtons disease_Homo sapiens_hsa050162.94053454
6Proteasome_Homo sapiens_hsa030502.59796398
7Alzheimers disease_Homo sapiens_hsa050102.49148916
8Cardiac muscle contraction_Homo sapiens_hsa042602.34731056
9RNA polymerase_Homo sapiens_hsa030202.13449452
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13342388
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.99885862
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92212974
13Mismatch repair_Homo sapiens_hsa034301.86817242
14Homologous recombination_Homo sapiens_hsa034401.83944607
15Propanoate metabolism_Homo sapiens_hsa006401.80342794
16Basal transcription factors_Homo sapiens_hsa030221.67419982
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49096974
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48570286
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46328039
20Fanconi anemia pathway_Homo sapiens_hsa034601.46240988
21Phototransduction_Homo sapiens_hsa047441.40549927
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40210639
23RNA degradation_Homo sapiens_hsa030181.38056593
24Nicotine addiction_Homo sapiens_hsa050331.35740410
25Non-homologous end-joining_Homo sapiens_hsa034501.32553199
26Nucleotide excision repair_Homo sapiens_hsa034201.31897098
27Butanoate metabolism_Homo sapiens_hsa006501.31491906
28Base excision repair_Homo sapiens_hsa034101.31375325
29Pyruvate metabolism_Homo sapiens_hsa006201.29504538
30Spliceosome_Homo sapiens_hsa030401.28873840
31DNA replication_Homo sapiens_hsa030301.27002508
32Folate biosynthesis_Homo sapiens_hsa007901.22050775
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16410904
34RNA transport_Homo sapiens_hsa030131.11793232
35Fatty acid elongation_Homo sapiens_hsa000621.11753180
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11307822
37Steroid biosynthesis_Homo sapiens_hsa001001.10935471
38Pyrimidine metabolism_Homo sapiens_hsa002401.09137310
39Peroxisome_Homo sapiens_hsa041461.07918556
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.07865468
41Tryptophan metabolism_Homo sapiens_hsa003801.06910110
42Glutathione metabolism_Homo sapiens_hsa004801.04649044
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04246713
44One carbon pool by folate_Homo sapiens_hsa006700.99666763
45Purine metabolism_Homo sapiens_hsa002300.98103684
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97673402
47Chemical carcinogenesis_Homo sapiens_hsa052040.95438810
48Nitrogen metabolism_Homo sapiens_hsa009100.94721435
49Primary bile acid biosynthesis_Homo sapiens_hsa001200.89061879
50Basal cell carcinoma_Homo sapiens_hsa052170.86518269
51Metabolic pathways_Homo sapiens_hsa011000.85009697
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.81844755
53Linoleic acid metabolism_Homo sapiens_hsa005910.80991300
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79679975
55Sulfur relay system_Homo sapiens_hsa041220.78981371
56beta-Alanine metabolism_Homo sapiens_hsa004100.78245622
57Collecting duct acid secretion_Homo sapiens_hsa049660.78130643
58Caffeine metabolism_Homo sapiens_hsa002320.77949289
59Selenocompound metabolism_Homo sapiens_hsa004500.76774002
60Hedgehog signaling pathway_Homo sapiens_hsa043400.75760818
61Taste transduction_Homo sapiens_hsa047420.69002139
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68883732
63GABAergic synapse_Homo sapiens_hsa047270.67991674
64Fatty acid degradation_Homo sapiens_hsa000710.65767788
65Retinol metabolism_Homo sapiens_hsa008300.63819172
66Olfactory transduction_Homo sapiens_hsa047400.63244141
67Cell cycle_Homo sapiens_hsa041100.63148172
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.61597427
69Regulation of autophagy_Homo sapiens_hsa041400.59264063
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58655533
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58311886
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56529046
73Tyrosine metabolism_Homo sapiens_hsa003500.56243948
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55385010
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54090662
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52954939
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52766541
78Oocyte meiosis_Homo sapiens_hsa041140.52091764
79Arginine and proline metabolism_Homo sapiens_hsa003300.47121035
80Morphine addiction_Homo sapiens_hsa050320.46722865
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46634550
82Carbon metabolism_Homo sapiens_hsa012000.46352584
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43707122
84Serotonergic synapse_Homo sapiens_hsa047260.42995492
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41820922
86Histidine metabolism_Homo sapiens_hsa003400.39045114
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38846910
88Cocaine addiction_Homo sapiens_hsa050300.38835300
89Ether lipid metabolism_Homo sapiens_hsa005650.38785616
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38125315
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38104657
92Hippo signaling pathway_Homo sapiens_hsa043900.37423178
93Phenylalanine metabolism_Homo sapiens_hsa003600.37265221
94Sulfur metabolism_Homo sapiens_hsa009200.35712774
95Synaptic vesicle cycle_Homo sapiens_hsa047210.33674394
96Circadian entrainment_Homo sapiens_hsa047130.33531492
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33167347
98Arachidonic acid metabolism_Homo sapiens_hsa005900.33070790
99Fatty acid metabolism_Homo sapiens_hsa012120.32775229
100Glutamatergic synapse_Homo sapiens_hsa047240.32636410

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