C11ORF84

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.30488880
2heterochromatin organization (GO:0070828)5.27753938
3mitotic chromosome condensation (GO:0007076)4.62595492
4planar cell polarity pathway involved in neural tube closure (GO:0090179)4.48331439
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.24973681
6protein complex localization (GO:0031503)4.06702941
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.05585815
8nuclear pore complex assembly (GO:0051292)3.88556684
9peptidyl-arginine omega-N-methylation (GO:0035247)3.85793452
10protein-DNA complex disassembly (GO:0032986)3.84139634
11nucleosome disassembly (GO:0006337)3.84139634
12regulation of translational fidelity (GO:0006450)3.69980731
13paraxial mesoderm development (GO:0048339)3.66150414
14histone arginine methylation (GO:0034969)3.65822751
15cellular protein complex localization (GO:0034629)3.62252881
16protein localization to chromosome, centromeric region (GO:0071459)3.56801516
17negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.55652953
18convergent extension (GO:0060026)3.54104586
19proline biosynthetic process (GO:0006561)3.49200359
20ribosomal small subunit biogenesis (GO:0042274)3.48867152
21apoptotic process involved in morphogenesis (GO:0060561)3.46683080
22pre-miRNA processing (GO:0031054)3.41939209
23RNA stabilization (GO:0043489)3.41658238
24mRNA stabilization (GO:0048255)3.41658238
25adherens junction assembly (GO:0034333)3.39184644
26DNA replication initiation (GO:0006270)3.38937377
27spliceosomal tri-snRNP complex assembly (GO:0000244)3.37140861
28DNA strand elongation involved in DNA replication (GO:0006271)3.34184324
29chromosome condensation (GO:0030261)3.33952313
30chromatin assembly (GO:0031497)3.30912418
31DNA strand elongation (GO:0022616)3.29127981
32nuclear pore organization (GO:0006999)3.25906126
33protein localization to kinetochore (GO:0034501)3.21403899
34formation of translation preinitiation complex (GO:0001731)3.17835158
35regulation of NFAT protein import into nucleus (GO:0051532)3.16009623
36peptidyl-arginine methylation (GO:0018216)3.15603120
37peptidyl-arginine N-methylation (GO:0035246)3.15603120
38establishment of integrated proviral latency (GO:0075713)3.14552934
39establishment of apical/basal cell polarity (GO:0035089)3.13978763
40cell-substrate adherens junction assembly (GO:0007045)3.12482900
41focal adhesion assembly (GO:0048041)3.12482900
42mitotic sister chromatid segregation (GO:0000070)3.07101847
43regulation of chromatin binding (GO:0035561)3.01329192
44regulation of early endosome to late endosome transport (GO:2000641)2.98206195
45protein retention in ER lumen (GO:0006621)2.94889701
46regulation of RNA export from nucleus (GO:0046831)2.92649318
47negative regulation of histone methylation (GO:0031061)2.92473252
48regulation of stem cell maintenance (GO:2000036)2.92076432
49COPI coating of Golgi vesicle (GO:0048205)2.88360920
50Golgi transport vesicle coating (GO:0048200)2.88360920
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85513414
523-UTR-mediated mRNA stabilization (GO:0070935)2.84050759
53DNA duplex unwinding (GO:0032508)2.83852190
54positive regulation of DNA-dependent DNA replication (GO:2000105)2.83105916
55rRNA transcription (GO:0009303)2.82841356
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.81938484
57negative regulation of mRNA processing (GO:0050686)2.81818337
58pore complex assembly (GO:0046931)2.81152663
59regulation of translational termination (GO:0006449)2.81141929
60sister chromatid segregation (GO:0000819)2.80250433
61activation of Rac GTPase activity (GO:0032863)2.80220565
62mitotic sister chromatid cohesion (GO:0007064)2.77214465
63negative regulation of mRNA metabolic process (GO:1903312)2.77104239
64negative regulation of DNA repair (GO:0045738)2.75490004
65L-serine metabolic process (GO:0006563)2.74399112
66mitotic metaphase plate congression (GO:0007080)2.74326250
67DNA packaging (GO:0006323)2.74186297
68positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.73022162
69negative regulation of cell size (GO:0045792)2.72324846
70protein export from nucleus (GO:0006611)2.67654128
71notochord development (GO:0030903)2.66355165
72positive regulation of chromosome segregation (GO:0051984)2.65750868
73DNA conformation change (GO:0071103)2.63419308
74regulation of establishment of planar polarity (GO:0090175)2.63153885
75DNA geometric change (GO:0032392)2.62772595
76regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.60731307
77mitotic G1 DNA damage checkpoint (GO:0031571)2.59299972
78regulation of nucleobase-containing compound transport (GO:0032239)2.59212105
79telomere maintenance via semi-conservative replication (GO:0032201)2.58928590
80cochlea morphogenesis (GO:0090103)2.55607127
81protein localization to endosome (GO:0036010)2.55176010
82intracellular estrogen receptor signaling pathway (GO:0030520)2.54716889
83mitotic nuclear envelope disassembly (GO:0007077)2.54436331
84maturation of SSU-rRNA (GO:0030490)2.53523956
85regulation of mRNA stability (GO:0043488)2.53423458
86DNA topological change (GO:0006265)2.53376386
87trophoblast giant cell differentiation (GO:0060707)2.53286199
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.52685604
89negative regulation of RNA splicing (GO:0033119)2.49784025
90maternal placenta development (GO:0001893)2.48772971
91regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.48764559
92cytoskeletal anchoring at plasma membrane (GO:0007016)2.48745992
93positive regulation of SMAD protein import into nucleus (GO:0060391)2.47732404
94protein maturation by protein folding (GO:0022417)2.46728771
95viral mRNA export from host cell nucleus (GO:0046784)2.46402723
96viral transcription (GO:0019083)2.46283176
97basement membrane organization (GO:0071711)2.45333239
98establishment of viral latency (GO:0019043)2.45256835
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.44574300
100pentose-phosphate shunt (GO:0006098)2.44067865

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54464191
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.33355531
3MYC_22102868_ChIP-Seq_BL_Human2.92397681
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86978067
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.83750524
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57752904
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.53572138
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31990982
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.31321323
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.22411521
11VDR_21846776_ChIP-Seq_THP-1_Human2.13058588
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.12991897
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12060965
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09790860
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.09390860
16LXR_22292898_ChIP-Seq_THP-1_Human2.04481677
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04446635
18* ELK3_25401928_ChIP-Seq_HUVEC_Human2.03664128
19CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.97424796
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91336790
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89597278
22MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88840668
23XRN2_22483619_ChIP-Seq_HELA_Human1.87429994
24KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.86738199
25ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82058878
26* RACK7_27058665_Chip-Seq_MCF-7_Human1.81360522
27ZNF263_19887448_ChIP-Seq_K562_Human1.79316336
28CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72634453
29ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72382985
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70958977
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.70622388
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.68362627
33KLF4_18555785_ChIP-Seq_MESCs_Mouse1.63164291
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60138319
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56206334
36KDM2B_26808549_Chip-Seq_DND41_Human1.54219010
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53664554
38TCF7_22412390_ChIP-Seq_EML_Mouse1.52391119
39CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.51708676
40KDM2B_26808549_Chip-Seq_K562_Human1.50810808
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50623989
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50032494
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47300079
44NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45514009
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44203107
46AR_21909140_ChIP-Seq_LNCAP_Human1.41702702
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40161957
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40131859
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.39223499
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38653630
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.37400769
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35295217
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.35060312
54* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34702599
55TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32114015
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28898190
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27570117
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.27091722
59* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25143312
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24931730
61KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.24750479
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.24750479
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.24750479
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24558752
65SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24213908
66CLOCK_20551151_ChIP-Seq_293T_Human1.23184192
67CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23116799
68P68_20966046_ChIP-Seq_HELA_Human1.22255645
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21581411
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20858065
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19113819
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17449397
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.16544364
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16485762
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15059779
76TTF2_22483619_ChIP-Seq_HELA_Human1.15014382
77ATF3_27146783_Chip-Seq_COLON_Human1.13479060
78* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13467420
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12748688
80E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12723458
81SA1_27219007_Chip-Seq_ERYTHROID_Human1.11628688
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09936943
83CREB1_26743006_Chip-Seq_LNCaP_Human1.09615866
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09206386
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09052769
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08327265
87NCOR1_26117541_ChIP-Seq_K562_Human1.07563467
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.07457153
89* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07208976
90TP53_22127205_ChIP-Seq_IMR90_Human1.06007041
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04954410
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03051533
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02285621
94DCP1A_22483619_ChIP-Seq_HELA_Human1.00689230
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00250541
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99035659
97SMC4_20622854_ChIP-Seq_HELA_Human0.97978660
98PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97747156
99KDM5A_27292631_Chip-Seq_BREAST_Human0.94673180
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94517465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.94762488
2MP0003111_abnormal_nucleus_morphology2.94922734
3MP0010030_abnormal_orbit_morphology2.94216932
4MP0003693_abnormal_embryo_hatching2.91366543
5MP0000537_abnormal_urethra_morphology2.77491868
6MP0004957_abnormal_blastocyst_morpholog2.61738903
7MP0005076_abnormal_cell_differentiation2.57384107
8MP0004858_abnormal_nervous_system2.32742553
9MP0005623_abnormal_meninges_morphology2.25718910
10MP0001730_embryonic_growth_arrest2.25312010
11MP0009672_abnormal_birth_weight2.24690742
12MP0010094_abnormal_chromosome_stability2.21668342
13MP0001849_ear_inflammation2.19448445
14MP0003077_abnormal_cell_cycle2.17568557
15MP0004185_abnormal_adipocyte_glucose2.16151574
16MP0008932_abnormal_embryonic_tissue2.08699965
17MP0000566_synostosis2.04681247
18MP0002877_abnormal_melanocyte_morpholog2.00446194
19MP0004233_abnormal_muscle_weight1.94758266
20MP0003566_abnormal_cell_adhesion1.87832793
21MP0004272_abnormal_basement_membrane1.87131838
22MP0000350_abnormal_cell_proliferation1.86474456
23MP0009053_abnormal_anal_canal1.86395363
24MP0002254_reproductive_system_inflammat1.82119757
25MP0005257_abnormal_intraocular_pressure1.81869328
26MP0005451_abnormal_body_composition1.81186597
27MP0000678_abnormal_parathyroid_gland1.75952231
28MP0002089_abnormal_postnatal_growth/wei1.75154227
29MP0005380_embryogenesis_phenotype1.70790102
30MP0001672_abnormal_embryogenesis/_devel1.70790102
31MP0002249_abnormal_larynx_morphology1.67992363
32MP0002697_abnormal_eye_size1.67307001
33MP0002085_abnormal_embryonic_tissue1.64890798
34MP0010234_abnormal_vibrissa_follicle1.63537822
35MP0010352_gastrointestinal_tract_polyps1.62086502
36MP0003123_paternal_imprinting1.59036067
37MP0001346_abnormal_lacrimal_gland1.56936789
38MP0003984_embryonic_growth_retardation1.56446010
39MP0002080_prenatal_lethality1.49749841
40MP0000733_abnormal_muscle_development1.48916363
41MP0003942_abnormal_urinary_system1.48619908
42MP0002088_abnormal_embryonic_growth/wei1.46507096
43MP0000428_abnormal_craniofacial_morphol1.44677825
44MP0002084_abnormal_developmental_patter1.40657494
45MP0008438_abnormal_cutaneous_collagen1.39149353
46MP0001697_abnormal_embryo_size1.38647796
47MP0001348_abnormal_lacrimal_gland1.34025950
48MP0010307_abnormal_tumor_latency1.33046733
49MP0002086_abnormal_extraembryonic_tissu1.27073836
50MP0003453_abnormal_keratinocyte_physiol1.26754806
51MP0008057_abnormal_DNA_replication1.26693955
52MP0002092_abnormal_eye_morphology1.25443484
53MP0009278_abnormal_bone_marrow1.24988547
54MP0002796_impaired_skin_barrier1.24067490
55MP0005501_abnormal_skin_physiology1.23886210
56MP0000049_abnormal_middle_ear1.21877386
57MP0004197_abnormal_fetal_growth/weight/1.20223392
58MP0008007_abnormal_cellular_replicative1.18621809
59MP0003937_abnormal_limbs/digits/tail_de1.18359669
60MP0003385_abnormal_body_wall1.17211773
61MP0003941_abnormal_skin_development1.14808002
62MP0003115_abnormal_respiratory_system1.13847514
63MP0002111_abnormal_tail_morphology1.12571460
64MP0000534_abnormal_ureter_morphology1.12066047
65MP0003283_abnormal_digestive_organ1.11556200
66MP0000003_abnormal_adipose_tissue1.08988769
67MP0003315_abnormal_perineum_morphology1.07785120
68MP0004808_abnormal_hematopoietic_stem1.07757462
69MP0003091_abnormal_cell_migration1.07118293
70MP0000313_abnormal_cell_death1.06404450
71MP0000762_abnormal_tongue_morphology1.06182409
72MP0001915_intracranial_hemorrhage1.03691495
73MP0000432_abnormal_head_morphology1.02215350
74MP0003935_abnormal_craniofacial_develop1.01907499
75MP0003861_abnormal_nervous_system1.01825887
76MP0005666_abnormal_adipose_tissue1.00461547
77MP0000490_abnormal_crypts_of0.96570127
78MP0010368_abnormal_lymphatic_system0.95991678
79MP0010630_abnormal_cardiac_muscle0.94212661
80MP0002116_abnormal_craniofacial_bone0.93390960
81MP0009703_decreased_birth_body0.92694849
82MP0002396_abnormal_hematopoietic_system0.91488021
83MP0009250_abnormal_appendicular_skeleto0.91067933
84MP0001286_abnormal_eye_development0.90961164
85MP0003119_abnormal_digestive_system0.90860147
86MP0001661_extended_life_span0.90583834
87MP0005375_adipose_tissue_phenotype0.89904710
88MP0005621_abnormal_cell_physiology0.89407225
89MP0001293_anophthalmia0.88018964
90MP0002925_abnormal_cardiovascular_devel0.87169741
91MP0005409_darkened_coat_color0.86107720
92MP0001299_abnormal_eye_distance/0.85701252
93MP0002163_abnormal_gland_morphology0.85444546
94MP0000579_abnormal_nail_morphology0.82697639
95MP0002114_abnormal_axial_skeleton0.81628537
96MP0002234_abnormal_pharynx_morphology0.79718962
97MP0004264_abnormal_extraembryonic_tissu0.79481558
98MP0000858_altered_metastatic_potential0.79162806
99MP0003755_abnormal_palate_morphology0.78669195
100MP0000767_abnormal_smooth_muscle0.77876968

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.83574865
2Ulnar bowing (HP:0003031)3.02313352
3Premature rupture of membranes (HP:0001788)2.96016191
4Shallow orbits (HP:0000586)2.94126859
5Long palpebral fissure (HP:0000637)2.80174429
6Asymmetry of the thorax (HP:0001555)2.75405566
7Selective tooth agenesis (HP:0001592)2.67670582
8Broad distal phalanx of finger (HP:0009836)2.67377909
9Protrusio acetabuli (HP:0003179)2.61583544
10Insomnia (HP:0100785)2.54867658
11Disproportionate tall stature (HP:0001519)2.50055641
12Turricephaly (HP:0000262)2.47620924
13Abnormality of the distal phalanx of the thumb (HP:0009617)2.40369823
14Renal duplication (HP:0000075)2.36838128
15Achilles tendon contracture (HP:0001771)2.35883766
16Increased nuchal translucency (HP:0010880)2.35429011
17Overriding aorta (HP:0002623)2.34622085
18Trismus (HP:0000211)2.26632711
19Arnold-Chiari malformation (HP:0002308)2.24173316
20Abnormality of the phalanges of the hallux (HP:0010057)2.20557843
21Partial duplication of thumb phalanx (HP:0009944)2.18407839
22Partial duplication of the phalanx of hand (HP:0009999)2.15656652
23Genu recurvatum (HP:0002816)2.14234241
24High anterior hairline (HP:0009890)2.13273651
25Broad thumb (HP:0011304)2.08971193
26Deep palmar crease (HP:0006191)2.06270503
27Elfin facies (HP:0004428)2.05931368
28Abnormality of the Achilles tendon (HP:0005109)2.03832591
29Flat acetabular roof (HP:0003180)2.03504500
30Patellar dislocation (HP:0002999)2.03102995
31Deviation of the thumb (HP:0009603)2.01579018
32Broad face (HP:0000283)1.99704655
33Duplication of thumb phalanx (HP:0009942)1.96178289
34Thin ribs (HP:0000883)1.94545295
35Premature skin wrinkling (HP:0100678)1.94070076
36Anal stenosis (HP:0002025)1.93353872
37Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90171393
38Proximal placement of thumb (HP:0009623)1.89803741
39Intestinal fistula (HP:0100819)1.89728982
40Progressive muscle weakness (HP:0003323)1.88754616
41Biconcave vertebral bodies (HP:0004586)1.88314079
42Uterine leiomyosarcoma (HP:0002891)1.88281549
43Leiomyosarcoma (HP:0100243)1.88281549
44Ankyloglossia (HP:0010296)1.87771558
45Dysmetric saccades (HP:0000641)1.87514514
46Skull defect (HP:0001362)1.86398339
47Pointed chin (HP:0000307)1.86240562
48Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85807692
49Choanal stenosis (HP:0000452)1.83871236
50Truncus arteriosus (HP:0001660)1.82180699
51Long eyelashes (HP:0000527)1.81731246
52Renovascular hypertension (HP:0100817)1.80818010
53Atresia of the external auditory canal (HP:0000413)1.80496789
54Reticulocytopenia (HP:0001896)1.79470330
55Pseudobulbar signs (HP:0002200)1.77137099
56Broad phalanges of the hand (HP:0009768)1.76680579
57Coronal craniosynostosis (HP:0004440)1.75709119
58Abnormality of dentin (HP:0010299)1.74977201
59Abnormality of the aortic arch (HP:0012303)1.74506191
60Natal tooth (HP:0000695)1.74232488
61Syringomyelia (HP:0003396)1.74192797
62Spinal cord lesions (HP:0100561)1.74192797
63Upper limb amyotrophy (HP:0009129)1.72188225
64Distal upper limb amyotrophy (HP:0007149)1.72188225
65Trigonocephaly (HP:0000243)1.71938586
66Abnormality of the distal phalanges of the toes (HP:0010182)1.70657505
67Abnormality of the fingertips (HP:0001211)1.69799506
68Sparse lateral eyebrow (HP:0005338)1.69026607
69Blue sclerae (HP:0000592)1.68676820
70Abnormality of oral frenula (HP:0000190)1.68602118
71Multiple enchondromatosis (HP:0005701)1.67262107
72Bronchomalacia (HP:0002780)1.67213994
73Vertebral compression fractures (HP:0002953)1.67147358
74Deviation of the hallux (HP:0010051)1.66750055
75Transposition of the great arteries (HP:0001669)1.66377280
76Abnormal connection of the cardiac segments (HP:0011545)1.66377280
77Abnormal ventriculo-arterial connection (HP:0011563)1.66377280
78Abnormal number of incisors (HP:0011064)1.66257237
79Preauricular skin tag (HP:0000384)1.65212205
80Broad finger (HP:0001500)1.65173587
81Advanced eruption of teeth (HP:0006288)1.64560827
82Midface retrusion (HP:0011800)1.64400429
83Abnormality of the calcaneus (HP:0008364)1.64293559
84Facial cleft (HP:0002006)1.64290164
85Generalized hypotonia (HP:0001290)1.63848968
86Urethral obstruction (HP:0000796)1.63783872
87Spastic diplegia (HP:0001264)1.63768271
88Renal cell carcinoma (HP:0005584)1.63570096
89Spinal rigidity (HP:0003306)1.62413247
90Fragile skin (HP:0001030)1.61067376
91Distal lower limb amyotrophy (HP:0008944)1.60950059
92Gastrointestinal carcinoma (HP:0002672)1.60764881
93Malignant gastrointestinal tract tumors (HP:0006749)1.60764881
94Abnormal ossification of hand bones (HP:0005921)1.60460514
95Abnormality of the umbilical cord (HP:0010881)1.59732637
96Breast hypoplasia (HP:0003187)1.58581081
97Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58468725
98Abnormality of the thoracic spine (HP:0100711)1.58225708
99Congenital glaucoma (HP:0001087)1.58214141
100Bladder diverticulum (HP:0000015)1.57745446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.49005891
2TRIB34.27033168
3EEF2K3.70600387
4MAP3K103.34683860
5CDK123.27002321
6ICK2.90137372
7NME22.54655295
8IRAK32.52688746
9SIK12.12761527
10PRPF4B2.10325505
11LATS21.78533280
12CDC71.78427541
13BUB11.78093934
14VRK21.77713996
15TTK1.70015849
16PDGFRA1.57898389
17PKN21.47090676
18FGFR41.45935350
19MAP3K91.45903128
20CDK71.37396016
21PAK41.36303646
22ARAF1.32928461
23EPHA21.30561642
24CHEK21.28585118
25PRKD31.28154070
26CAMK1D1.27412988
27MTOR1.27386482
28RPS6KB21.27137216
29BRAF1.24801292
30TTN1.24275045
31TAF11.23654862
32BRD41.18671890
33RIPK11.16719416
34ERN11.14790421
35MAP3K81.13020376
36TYRO31.10967057
37PTK21.10169718
38CDK41.05464241
39TAOK21.05066462
40CAMK1G1.02600154
41PASK0.94320404
42NTRK10.93878075
43MAP3K130.91332600
44SRPK10.85732233
45KSR20.81385801
46AURKA0.81147345
47ILK0.79824582
48CHEK10.77684518
49TSSK60.77533549
50NEK20.77203264
51PTK60.75872577
52BMX0.75170405
53TESK10.74673156
54KDR0.74240475
55CDK80.71873394
56IRAK20.70411597
57TESK20.69648748
58BRSK10.68043151
59CDK90.65461187
60STK40.65451201
61RPS6KA20.64535490
62RPS6KC10.63938516
63RPS6KL10.63938516
64DDR20.63139322
65MET0.59743604
66AKT20.59338286
67STK240.58443098
68MARK20.57832588
69PAK20.56189822
70ATR0.55397900
71CDK20.54744190
72CDK60.54343342
73TAOK10.53948352
74ALK0.53717089
75CDC42BPA0.53665387
76CDK11A0.53090787
77AURKB0.52690851
78MAP2K30.52619315
79MAP2K20.50547859
80PLK40.48570865
81DYRK30.48453723
82DMPK0.48335892
83CDK150.47998830
84CDK10.47862112
85MAPK110.47831598
86SIK20.46818314
87MOS0.45609065
88CLK10.44106887
89PRKG20.43708583
90MAP3K110.43001333
91CDK180.41627710
92LRRK20.41406348
93HIPK20.41039006
94RPS6KA60.40751317
95FGFR20.40445789
96PIM20.39180119
97PLK10.38902591
98RPS6KA10.38813848
99WEE10.38621005
100SCYL20.37981681

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.20099101
2Bladder cancer_Homo sapiens_hsa052192.10915602
3Cell cycle_Homo sapiens_hsa041102.09078193
4Chronic myeloid leukemia_Homo sapiens_hsa052202.04266413
5Spliceosome_Homo sapiens_hsa030402.00668165
6Base excision repair_Homo sapiens_hsa034101.95892569
7Central carbon metabolism in cancer_Homo sapiens_hsa052301.89134582
8Thyroid cancer_Homo sapiens_hsa052161.83702752
9Notch signaling pathway_Homo sapiens_hsa043301.82076826
10mRNA surveillance pathway_Homo sapiens_hsa030151.75613781
11Sulfur relay system_Homo sapiens_hsa041221.69750798
12Biosynthesis of amino acids_Homo sapiens_hsa012301.68645646
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.66060280
14Vitamin B6 metabolism_Homo sapiens_hsa007501.64493653
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64109592
16Ribosome_Homo sapiens_hsa030101.60084570
17RNA transport_Homo sapiens_hsa030131.59568941
18Mismatch repair_Homo sapiens_hsa034301.58625439
19Basal cell carcinoma_Homo sapiens_hsa052171.58608884
20MicroRNAs in cancer_Homo sapiens_hsa052061.53523639
21Non-small cell lung cancer_Homo sapiens_hsa052231.50857343
22Endometrial cancer_Homo sapiens_hsa052131.38368870
23Pentose phosphate pathway_Homo sapiens_hsa000301.38051168
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37642403
25Adherens junction_Homo sapiens_hsa045201.34321741
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31882410
27Hippo signaling pathway_Homo sapiens_hsa043901.30638365
28Prostate cancer_Homo sapiens_hsa052151.27537446
29Acute myeloid leukemia_Homo sapiens_hsa052211.26043473
30Small cell lung cancer_Homo sapiens_hsa052221.25804958
31Pancreatic cancer_Homo sapiens_hsa052121.25353394
32Glioma_Homo sapiens_hsa052141.23415753
33Lysine degradation_Homo sapiens_hsa003101.21088801
34Prion diseases_Homo sapiens_hsa050201.20291486
35Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19506397
36VEGF signaling pathway_Homo sapiens_hsa043701.18376170
37Colorectal cancer_Homo sapiens_hsa052101.17821637
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17394408
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13872893
40One carbon pool by folate_Homo sapiens_hsa006701.13296606
41Proteoglycans in cancer_Homo sapiens_hsa052051.12117386
42ErbB signaling pathway_Homo sapiens_hsa040121.07544597
43Nucleotide excision repair_Homo sapiens_hsa034201.06870764
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04637961
45Wnt signaling pathway_Homo sapiens_hsa043101.03882888
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01343547
47N-Glycan biosynthesis_Homo sapiens_hsa005101.00264361
48Insulin signaling pathway_Homo sapiens_hsa049100.97286254
49Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95779461
50Pyrimidine metabolism_Homo sapiens_hsa002400.95714295
51Neurotrophin signaling pathway_Homo sapiens_hsa047220.95189685
52HTLV-I infection_Homo sapiens_hsa051660.94914515
53Viral carcinogenesis_Homo sapiens_hsa052030.94424696
54p53 signaling pathway_Homo sapiens_hsa041150.93822460
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93618944
56Renal cell carcinoma_Homo sapiens_hsa052110.93514350
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93101058
58Focal adhesion_Homo sapiens_hsa045100.92263725
59Galactose metabolism_Homo sapiens_hsa000520.91869749
60Hedgehog signaling pathway_Homo sapiens_hsa043400.88889071
61Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88175653
62Melanoma_Homo sapiens_hsa052180.86504964
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86462263
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86202336
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.85840277
66mTOR signaling pathway_Homo sapiens_hsa041500.85082115
67AMPK signaling pathway_Homo sapiens_hsa041520.80774878
68Carbon metabolism_Homo sapiens_hsa012000.76550878
69Other glycan degradation_Homo sapiens_hsa005110.76534441
70Hepatitis B_Homo sapiens_hsa051610.76162356
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75695321
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75655613
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74982231
74Melanogenesis_Homo sapiens_hsa049160.74887342
75Apoptosis_Homo sapiens_hsa042100.73936715
76Fructose and mannose metabolism_Homo sapiens_hsa000510.73372130
77Tight junction_Homo sapiens_hsa045300.72397690
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.71208486
79Pathways in cancer_Homo sapiens_hsa052000.70072157
80Estrogen signaling pathway_Homo sapiens_hsa049150.69639504
81Shigellosis_Homo sapiens_hsa051310.68343150
82ECM-receptor interaction_Homo sapiens_hsa045120.66768375
83B cell receptor signaling pathway_Homo sapiens_hsa046620.66146547
84Non-homologous end-joining_Homo sapiens_hsa034500.63685283
85Epstein-Barr virus infection_Homo sapiens_hsa051690.59318258
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58185793
87HIF-1 signaling pathway_Homo sapiens_hsa040660.52600077
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.52025520
89TGF-beta signaling pathway_Homo sapiens_hsa043500.51437639
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49031014
91Prolactin signaling pathway_Homo sapiens_hsa049170.48187098
92Alcoholism_Homo sapiens_hsa050340.47991176
93Inositol phosphate metabolism_Homo sapiens_hsa005620.47712138
94Oocyte meiosis_Homo sapiens_hsa041140.47467605
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47453672
96Axon guidance_Homo sapiens_hsa043600.47035960
97Selenocompound metabolism_Homo sapiens_hsa004500.46599415
98Vibrio cholerae infection_Homo sapiens_hsa051100.46369645
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45372054
100Folate biosynthesis_Homo sapiens_hsa007900.45317178

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