ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	angiotensin maturation (GO:0002003)	9.97059803
2	regulation of guanylate cyclase activity (GO:0031282)	7.74647680
3	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	7.64210602
4	NADH metabolic process (GO:0006734)	7.23770704
5	intestinal absorption (GO:0050892)	6.71162581
6	lipoprotein transport (GO:0042953)	6.54697022
7	positive regulation of guanylate cyclase activity (GO:0031284)	5.91339584
8	epoxygenase P450 pathway (GO:0019373)	5.83724915
9	fat-soluble vitamin biosynthetic process (GO:0042362)	5.70345944
10	regulation of bile acid biosynthetic process (GO:0070857)	5.70075996
11	fructose metabolic process (GO:0006000)	5.63609463
12	urea cycle (GO:0000050)	5.50799901
13	urea metabolic process (GO:0019627)	5.17568204
14	regulation of cellular extravasation (GO:0002691)	5.15877022
15	very-low-density lipoprotein particle assembly (GO:0034379)	4.98731891
16	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	4.87586132
17	endocrine process (GO:0050886)	4.87586132
18	regulation of systemic arterial blood pressure by hormone (GO:0001990)	4.87586132
19	antibacterial humoral response (GO:0019731)	4.80952109
20	hormone catabolic process (GO:0042447)	4.80080519
21	diacylglycerol metabolic process (GO:0046339)	4.79814021
22	regulation of cGMP biosynthetic process (GO:0030826)	4.77220578
23	nitrogen cycle metabolic process (GO:0071941)	4.74284358
24	antimicrobial humoral response (GO:0019730)	4.68081903
25	homocysteine metabolic process (GO:0050667)	4.64020983
26	positive regulation of pseudopodium assembly (GO:0031274)	4.61649454
27	receptor guanylyl cyclase signaling pathway (GO:0007168)	4.53964795
28	drug metabolic process (GO:0017144)	4.48378085
29	plasma lipoprotein particle assembly (GO:0034377)	4.46842753
30	regulation of triglyceride catabolic process (GO:0010896)	4.46239869
31	regulation of systemic arterial blood pressure (GO:0003073)	4.45349668
32	cellular glucuronidation (GO:0052695)	4.37643579
33	glucuronate metabolic process (GO:0019585)	4.36130410
34	uronic acid metabolic process (GO:0006063)	4.36130410
35	bile acid and bile salt transport (GO:0015721)	4.34800696
36	vitamin A metabolic process (GO:0006776)	4.31520786
37	adhesion of symbiont to host cell (GO:0044650)	4.25367658
38	virion attachment to host cell (GO:0019062)	4.25367658
39	midgut development (GO:0007494)	4.23770602
40	digestion (GO:0007586)	4.16098988
41	regulation of vitamin metabolic process (GO:0030656)	4.13184858
42	regulation of pseudopodium assembly (GO:0031272)	4.12149280
43	peptide hormone processing (GO:0016486)	4.07824054
44	protein-lipid complex assembly (GO:0065005)	4.06524094
45	renal system process involved in regulation of blood volume (GO:0001977)	4.02242083
46	regulation of cGMP metabolic process (GO:0030823)	4.00187340
47	flavonoid metabolic process (GO:0009812)	3.98753437
48	glycolipid catabolic process (GO:0019377)	3.94997797
49	glycosphingolipid catabolic process (GO:0046479)	3.93049447
50	peptide catabolic process (GO:0043171)	3.87848266
51	nucleoside diphosphate biosynthetic process (GO:0009133)	3.85601852
52	glutamine family amino acid biosynthetic process (GO:0009084)	3.81512032
53	maintenance of gastrointestinal epithelium (GO:0030277)	3.79631423
54	phospholipid efflux (GO:0033700)	3.77136354
55	lipoprotein metabolic process (GO:0042157)	3.72126337
56	vitamin transmembrane transport (GO:0035461)	3.71729829
57	positive regulation of glycoprotein biosynthetic process (GO:0010560)	3.71713420
58	adhesion of symbiont to host (GO:0044406)	3.69803948
59	cGMP-mediated signaling (GO:0019934)	3.63738359
60	cellular response to nitric oxide (GO:0071732)	3.62127492
61	vitamin transport (GO:0051180)	3.58029666
62	arginine metabolic process (GO:0006525)	3.57526600
63	regulation of cholesterol esterification (GO:0010872)	3.57106644
64	citrulline biosynthetic process (GO:0019240)	3.55373307
65	positive regulation of cGMP biosynthetic process (GO:0030828)	3.48675236
66	positive regulation of respiratory burst (GO:0060267)	3.47749522
67	alkaloid metabolic process (GO:0009820)	3.43218860
68	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.42012882
69	positive regulation of glycoprotein metabolic process (GO:1903020)	3.40067765
70	positive regulation of triglyceride lipase activity (GO:0061365)	3.37818929
71	positive regulation of lipoprotein lipase activity (GO:0051006)	3.37818929
72	cyclooxygenase pathway (GO:0019371)	3.36003494
73	fat-soluble vitamin metabolic process (GO:0006775)	3.33920074
74	response to nitric oxide (GO:0071731)	3.30191065
75	GDP-mannose metabolic process (GO:0019673)	3.26722825
76	eosinophil chemotaxis (GO:0048245)	3.26012417
77	positive regulation of lipid catabolic process (GO:0050996)	3.23072535
78	digestive system process (GO:0022600)	3.21124862
79	drinking behavior (GO:0042756)	3.20927283
80	glomerular filtration (GO:0003094)	3.20316096
81	transcytosis (GO:0045056)	3.16758284
82	citrulline metabolic process (GO:0000052)	3.16674742
83	bile acid metabolic process (GO:0008206)	3.14921106
84	glycosylceramide metabolic process (GO:0006677)	3.13592245
85	ceramide catabolic process (GO:0046514)	3.11746649
86	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.11208712
87	glycoside metabolic process (GO:0016137)	3.08760336
88	positive regulation of cGMP metabolic process (GO:0030825)	3.07604861
89	cobalamin metabolic process (GO:0009235)	3.07409526
90	drug catabolic process (GO:0042737)	3.07314725
91	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	3.06371782
92	drug transport (GO:0015893)	3.05049588
93	high-density lipoprotein particle remodeling (GO:0034375)	3.04947553
94	cellular response to reactive nitrogen species (GO:1902170)	3.04814973
95	regulation of cholesterol homeostasis (GO:2000188)	3.02351153
96	mRNA modification (GO:0016556)	3.01558621
97	plasma lipoprotein particle organization (GO:0071827)	2.99887682
98	glycerol metabolic process (GO:0006071)	2.98406042
99	renal filtration (GO:0097205)	2.98184538
100	macromolecular complex remodeling (GO:0034367)	2.97994226

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CDX2_20551321_ChIP-Seq_CACO-2_Human	5.25666785
2	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.64806059
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.70703214
4	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.60795443
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.53334630
6	SOX2_27498859_Chip-Seq_STOMACH_Mouse	3.07982524
7	GATA4_25053715_ChIP-Seq_YYC3_Human	2.98884331
8	GATA6_25053715_ChIP-Seq_YYC3_Human	2.82739837
9	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.76865409
10	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.71527830
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.53928857
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.49068594
13	ZNF263_19887448_ChIP-Seq_K562_Human	2.40484045
14	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.38327623
15	SOX2_20726797_ChIP-Seq_SW620_Human	2.35320059
16	* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	2.30158146
17	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	2.26490348
18	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.25757531
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.24901491
20	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.18612847
21	* LXR_22292898_ChIP-Seq_THP-1_Human	2.07694589
22	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.04552936
23	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.96415537
24	RACK7_27058665_Chip-Seq_MCF-7_Human	1.88406916
25	GATA1_22025678_ChIP-Seq_K562_Human	1.86546678
26	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.83795025
27	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.83451372
28	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.82240927
29	CLOCK_20551151_ChIP-Seq_293T_Human	1.80862365
30	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.70123494
31	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.68523525
32	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.67826985
33	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.64488405
34	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.64366951
35	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.62505924
36	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.61696237
37	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.57728491
38	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.55956351
39	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.55422606
40	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.51553073
41	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.51174324
42	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.47472753
43	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.42883674
44	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.41583508
45	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.38706445
46	* SA1_27219007_Chip-Seq_Bcells_Human	1.37156459
47	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.36448544
48	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.34827275
49	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.31760670
50	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.31402178
51	BCOR_27268052_Chip-Seq_Bcells_Human	1.30769483
52	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.29279506
53	AR_21909140_ChIP-Seq_LNCAP_Human	1.29234772
54	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.28284936
55	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.27837236
56	KLF5_25053715_ChIP-Seq_YYC3_Human	1.23088749
57	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.20330747
58	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.19840049
59	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.18736176
60	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.18212283
61	BCL6_27268052_Chip-Seq_Bcells_Human	1.17926498
62	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.17080183
63	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.14275411
64	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.10550327
65	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10263503
66	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.09965364
67	* CTCF_27219007_Chip-Seq_Bcells_Human	1.09932952
68	* RUNX1_27514584_Chip-Seq_MCF-7_Human	1.07820944
69	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.07100614
70	EGR1_19032775_ChIP-ChIP_M12_Human	1.07091055
71	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.06070545
72	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.05992692
73	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.01732123
74	GATA2_22383799_ChIP-Seq_G1ME_Mouse	1.01279139
75	* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.01198418
76	CREB1_26743006_Chip-Seq_LNCaP_Human	1.01066629
77	VDR_21846776_ChIP-Seq_THP-1_Human	1.00580191
78	GATA2_19941826_ChIP-Seq_K562_Human	0.99853164
79	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.99027118
80	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.97943896
81	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.97179090
82	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.96847341
83	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.94234856
84	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.94041653
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93091332
86	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.92179549
87	* ELK3_25401928_ChIP-Seq_HUVEC_Human	0.91829452
88	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.90995528
89	VDR_24763502_ChIP-Seq_THP-1_Human	0.90902769
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.90849172
91	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.90530178
92	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.90275229
93	STAT1_20625510_ChIP-Seq_HELA_Human	0.90048623
94	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.90035791
95	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.88525776
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.87957463
97	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.84544873
98	PHF8_20622854_ChIP-Seq_HELA_Human	0.84420099
99	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.83841914
100	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.83609457

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	8.64960665
2	MP0005085_abnormal_gallbladder_physiolo	4.68395879
3	MP0001666_abnormal_nutrient_absorption	4.62567183
4	MP0002139_abnormal_hepatobiliary_system	4.21873521
5	MP0009840_abnormal_foam_cell	3.86359400
6	MP0009379_abnormal_foot_pigmentation	3.86095518
7	MP0003183_abnormal_peptide_metabolism	3.81400770
8	MP0004019_abnormal_vitamin_homeostasis	3.68869802
9	MP0005365_abnormal_bile_salt	3.28356953
10	MP0004147_increased_porphyrin_level	3.25881563
11	MP0010234_abnormal_vibrissa_follicle	3.21312989
12	MP0004264_abnormal_extraembryonic_tissu	3.03986342
13	MP0010155_abnormal_intestine_physiology	2.91583936
14	MP0000490_abnormal_crypts_of	2.13340692
15	MP0010352_gastrointestinal_tract_polyps	2.09855917
16	MP0001664_abnormal_digestion	2.07564920
17	MP0010329_abnormal_lipoprotein_level	2.06360977
18	MP0003866_abnormal_defecation	2.02363419
19	MP0005409_darkened_coat_color	2.02186057
20	MP0005332_abnormal_amino_acid	1.93866030
21	MP0009643_abnormal_urine_homeostasis	1.83959929
22	MP0003806_abnormal_nucleotide_metabolis	1.61768645
23	MP0004858_abnormal_nervous_system	1.60426948
24	MP0000477_abnormal_intestine_morphology	1.58532036
25	MP0003868_abnormal_feces_composition	1.56237230
26	MP0005166_decreased_susceptibility_to	1.53470645
27	MP0001873_stomach_inflammation	1.51274116
28	MP0003718_maternal_effect	1.46846327
29	MP0001764_abnormal_homeostasis	1.45877067
30	MP0003252_abnormal_bile_duct	1.41735068
31	MP0000538_abnormal_urinary_bladder	1.41064148
32	MP0000678_abnormal_parathyroid_gland	1.38696461
33	MP0001765_abnormal_ion_homeostasis	1.37879382
34	MP0001188_hyperpigmentation	1.36563324
35	MP0005451_abnormal_body_composition	1.30983148
36	MP0002876_abnormal_thyroid_physiology	1.29847333
37	MP0004782_abnormal_surfactant_physiolog	1.28657178
38	MP0005670_abnormal_white_adipose	1.28167376
39	MP0001663_abnormal_digestive_system	1.27279895
40	MP0005636_abnormal_mineral_homeostasis	1.25674250
41	MP0002136_abnormal_kidney_physiology	1.22656689
42	MP0003879_abnormal_hair_cell	1.21405506
43	MP0002118_abnormal_lipid_homeostasis	1.17536367
44	MP0005584_abnormal_enzyme/coenzyme_acti	1.11727254
45	MP0002796_impaired_skin_barrier	1.11146306
46	MP0000462_abnormal_digestive_system	1.08728041
47	MP0005381_digestive/alimentary_phenotyp	1.05438335
48	MP0000609_abnormal_liver_physiology	1.02349469
49	MP0000537_abnormal_urethra_morphology	0.99436573
50	MP0005448_abnormal_energy_balance	0.98956346
51	MP0002971_abnormal_brown_adipose	0.91554956
52	MP0004270_analgesia	0.91498791
53	MP0001845_abnormal_inflammatory_respons	0.91021577
54	MP0001756_abnormal_urination	0.89143231
55	MP0005319_abnormal_enzyme/_coenzyme	0.87794326
56	MP0005535_abnormal_body_temperature	0.86947624
57	MP0003191_abnormal_cellular_cholesterol	0.84668026
58	MP0002166_altered_tumor_susceptibility	0.83107658
59	MP0002822_catalepsy	0.81306723
60	MP0005501_abnormal_skin_physiology	0.81273692
61	MP0002098_abnormal_vibrissa_morphology	0.80946281
62	MP0004043_abnormal_pH_regulation	0.79699103
63	MP0001501_abnormal_sleep_pattern	0.79529312
64	MP0005666_abnormal_adipose_tissue	0.75324650
65	MP0000013_abnormal_adipose_tissue	0.74999994
66	MP0000230_abnormal_systemic_arterial	0.74826675
67	MP0008469_abnormal_protein_level	0.74578253
68	MP0009115_abnormal_fat_cell	0.74405567
69	MP0009642_abnormal_blood_homeostasis	0.70588921
70	MP0009785_altered_susceptibility_to	0.69370402
71	MP0008875_abnormal_xenobiotic_pharmacok	0.69162115
72	MP0005165_increased_susceptibility_to	0.65593841
73	MP0005083_abnormal_biliary_tract	0.65435216
74	MP0009333_abnormal_splenocyte_physiolog	0.64229675
75	MP0002396_abnormal_hematopoietic_system	0.61662176
76	MP0003724_increased_susceptibility_to	0.61583296
77	MP0003693_abnormal_embryo_hatching	0.60565188
78	MP0002006_tumorigenesis	0.59129301
79	MP0000249_abnormal_blood_vessel	0.59071665
80	MP0000465_gastrointestinal_hemorrhage	0.58317406
81	MP0005025_abnormal_response_to	0.57907327
82	MP0002138_abnormal_hepatobiliary_system	0.57604270
83	MP0005058_abnormal_lysosome_morphology	0.57417647
84	MP0003436_decreased_susceptibility_to	0.57085235
85	MP0001881_abnormal_mammary_gland	0.56739455
86	MP0008872_abnormal_physiological_respon	0.56611526
87	MP0005334_abnormal_fat_pad	0.56429636
88	MP0002896_abnormal_bone_mineralization	0.55515952
89	MP0001835_abnormal_antigen_presentation	0.53882136
90	MP0006138_congestive_heart_failure	0.52376040
91	MP0009764_decreased_sensitivity_to	0.51891427
92	MP0003329_amyloid_beta_deposits	0.49151611
93	MP0001485_abnormal_pinna_reflex	0.48959212
94	MP0000604_amyloidosis	0.48794748
95	MP0003303_peritoneal_inflammation	0.48702281
96	MP0004947_skin_inflammation	0.48496895
97	MP0003953_abnormal_hormone_level	0.48102352
98	MP0006082_CNS_inflammation	0.47584225
99	MP0001790_abnormal_immune_system	0.46618177
100	MP0005387_immune_system_phenotype	0.46618177

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Malnutrition (HP:0004395)	7.59770192
2	Hydroxyprolinuria (HP:0003080)	6.47976786
3	Abnormality of proline metabolism (HP:0010907)	6.47976786
4	Hypobetalipoproteinemia (HP:0003563)	5.91057482
5	Abnormality of the vitamin B12 metabolism (HP:0004341)	4.87628003
6	Chronic diarrhea (HP:0002028)	4.82328806
7	Abnormality of vitamin B metabolism (HP:0004340)	4.54643263
8	Ileus (HP:0002595)	4.54220201
9	Fat malabsorption (HP:0002630)	4.39979242
10	Confusion (HP:0001289)	4.17466678
11	Widely patent fontanelles and sutures (HP:0004492)	4.11895420
12	Systemic lupus erythematosus (HP:0002725)	4.11219805
13	Acanthocytosis (HP:0001927)	4.10220196
14	Nausea (HP:0002018)	4.02682210
15	Alkalosis (HP:0001948)	4.02386004
16	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.67936994
17	Abnormality of vitamin metabolism (HP:0100508)	3.62649797
18	Abnormality of urine glucose concentration (HP:0011016)	3.62017126
19	Glycosuria (HP:0003076)	3.62017126
20	Proximal tubulopathy (HP:0000114)	3.60860274
21	Hyperactive renin-angiotensin system (HP:0000841)	3.59888548
22	Pigmentary retinal degeneration (HP:0001146)	3.51573960
23	Hyperglycinuria (HP:0003108)	3.47622187
24	Thin bony cortex (HP:0002753)	3.39659160
25	Metabolic alkalosis (HP:0200114)	3.39445196
26	Decreased circulating renin level (HP:0003351)	3.36277754
27	Hyperammonemia (HP:0001987)	3.16826763
28	Wide cranial sutures (HP:0010537)	3.15678153
29	Abdominal distention (HP:0003270)	3.09949080
30	Congenital sensorineural hearing impairment (HP:0008527)	3.07584745
31	Nephrolithiasis (HP:0000787)	3.05394992
32	Abnormality of renin-angiotensin system (HP:0000847)	3.04292946
33	Hyperuricemia (HP:0002149)	3.03985850
34	Increased purine levels (HP:0004368)	3.03985850
35	Hypolipoproteinemia (HP:0010981)	3.02316587
36	Abnormality of serine family amino acid metabolism (HP:0010894)	3.00538513
37	Abnormality of glycine metabolism (HP:0010895)	3.00538513
38	Xanthomatosis (HP:0000991)	2.91627391
39	Posterior subcapsular cataract (HP:0007787)	2.88409829
40	Megaloblastic anemia (HP:0001889)	2.87854561
41	Hypophosphatemia (HP:0002148)	2.84735235
42	Steatorrhea (HP:0002570)	2.78998337
43	Abnormal urine phosphate concentration (HP:0012599)	2.72542492
44	Hyperparathyroidism (HP:0000843)	2.67573637
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.66100386
46	Villous atrophy (HP:0011473)	2.63602376
47	Abnormality of small intestinal villus morphology (HP:0011472)	2.63602376
48	Abnormality of pyrimidine metabolism (HP:0004353)	2.61323774
49	Eczematoid dermatitis (HP:0000976)	2.60593512
50	Abnormality of nucleobase metabolism (HP:0010932)	2.58494049
51	Abnormality of purine metabolism (HP:0004352)	2.57197092
52	Hyperphosphaturia (HP:0003109)	2.48234469
53	Hemorrhage of the eye (HP:0011885)	2.40444505
54	Focal segmental glomerulosclerosis (HP:0000097)	2.40021081
55	Metabolic acidosis (HP:0001942)	2.36338713
56	Hypotension (HP:0002615)	2.32789544
57	Facial shape deformation (HP:0011334)	2.32729602
58	Potter facies (HP:0002009)	2.32729602
59	Right ventricular cardiomyopathy (HP:0011663)	2.31788492
60	Renal tubular acidosis (HP:0001947)	2.31735147
61	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.30016486
62	Dicarboxylic aciduria (HP:0003215)	2.30016486
63	Delayed epiphyseal ossification (HP:0002663)	2.28680725
64	Abnormality of magnesium homeostasis (HP:0004921)	2.27568218
65	Enlarged epiphyses (HP:0010580)	2.25414945
66	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.22666768
67	Abnormality of the costochondral junction (HP:0000919)	2.21257610
68	Subcapsular cataract (HP:0000523)	2.20097923
69	Cerebral palsy (HP:0100021)	2.17842063
70	Gout (HP:0001997)	2.17369315
71	Flat acetabular roof (HP:0003180)	2.16174117
72	Abnormal glucose tolerance (HP:0001952)	2.08131067
73	Hyperphosphatemia (HP:0002905)	2.06004221
74	Glomerulonephritis (HP:0000099)	2.05123577
75	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.03199795
76	Irritability (HP:0000737)	2.01293912
77	Growth hormone excess (HP:0000845)	2.01180603
78	Abnormality of glutamine family amino acid metabolism (HP:0010902)	10.6395916
79	Renal tubular dysfunction (HP:0000124)	1.99321678
80	Pili torti (HP:0003777)	1.99084601
81	Abnormality of complement system (HP:0005339)	1.97920104
82	Epidermoid cyst (HP:0200040)	1.97818645
83	Pancreatitis (HP:0001733)	1.97670015
84	Hypoalbuminemia (HP:0003073)	1.97136439
85	Abnormal albumin level (HP:0012116)	1.97136439
86	Lethargy (HP:0001254)	1.96255772
87	Nephritis (HP:0000123)	1.91214031
88	Glomerulosclerosis (HP:0000096)	1.88445854
89	Protuberant abdomen (HP:0001538)	1.87301994
90	Abnormality of alkaline phosphatase activity (HP:0004379)	1.87188358
91	Gastrointestinal dysmotility (HP:0002579)	1.86736299
92	Abnormal enzyme/coenzyme activity (HP:0012379)	1.85192460
93	Conjugated hyperbilirubinemia (HP:0002908)	1.82516356
94	Multiple lipomas (HP:0001012)	1.81854140
95	Macrocytic anemia (HP:0001972)	1.80844633
96	Vomiting (HP:0002013)	1.80363521
97	Complement deficiency (HP:0004431)	1.77736330
98	Dehydration (HP:0001944)	1.75729418
99	Abnormal hair laboratory examination (HP:0003328)	1.75354828
100	Intrahepatic cholestasis (HP:0001406)	1.73796363

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	7.53505240
2	MST1R	5.86503905
3	ERN1	4.57102724
4	PDK2	4.16530192
5	EPHA2	3.39118426
6	PRKG2	3.11014158
7	RIPK1	3.10544711
8	MAP3K10	2.78436881
9	TESK2	2.44850470
10	STK39	2.34697822
11	MET	2.26733018
12	EPHB2	1.99929143
13	OXSR1	1.90967484
14	PTK6	1.67762776
15	FGFR4	1.57614885
16	MAP3K12	1.49405892
17	MAP3K2	1.32828192
18	TYK2	1.31503056
19	PIK3CA	1.28795410
20	MAP2K2	1.26617457
21	DDR2	1.22431648
22	GRK6	1.21036585
23	PRPF4B	1.16348678
24	STK24	1.15179818
25	EPHA3	1.14686349
26	LMTK2	1.09977091
27	EPHB1	1.09775162
28	MATK	1.09092071
29	MAP3K1	1.07522849
30	PDPK1	1.06100330
31	TESK1	0.99866062
32	ABL2	0.96043548
33	MST4	0.94849505
34	MYLK	0.91309436
35	MAP4K1	0.88506788
36	AKT3	0.82018397
37	MAP3K11	0.80000773
38	MAPK11	0.78313299
39	TNIK	0.78291284
40	BMX	0.71506918
41	IRAK3	0.70499152
42	PAK4	0.69099911
43	PIM2	0.68714074
44	ERBB2	0.68038910
45	PBK	0.65882187
46	BMPR2	0.65255528
47	RIPK4	0.65186131
48	WNK4	0.64989059
49	NEK6	0.64665679
50	PDK1	0.64565853
51	NME2	0.63974032
52	EPHA4	0.62650662
53	CDC42BPA	0.62083987
54	PIM1	0.60026298
55	FGFR3	0.58620816
56	TRIB3	0.56178033
57	NLK	0.55380463
58	TAOK1	0.54206143
59	PRKACG	0.53600266
60	MUSK	0.51005213
61	PRKCA	0.49926054
62	MAP2K6	0.48836371
63	CDK19	0.47595806
64	PTK2	0.47341932
65	TBK1	0.46892125
66	CAMK2D	0.46140750
67	PRKAA2	0.45462271
68	IRAK1	0.44612139
69	PRKCZ	0.44269145
70	FER	0.42998990
71	PRKCI	0.41351591
72	KSR2	0.39798944
73	CAMK2G	0.38921460
74	MAP3K3	0.37302167
75	SRC	0.36343309
76	DYRK1B	0.35718517
77	MAP3K8	0.35479750
78	CDK6	0.33132875
79	PDGFRA	0.31918048
80	SMG1	0.31254505
81	PRKCD	0.29361461
82	NME1	0.29303680
83	BRAF	0.25944814
84	NEK1	0.25653425
85	GRK1	0.25370546
86	YES1	0.25275154
87	LRRK2	0.24737761
88	CAMK2B	0.23811791
89	MELK	0.22878025
90	FYN	0.22143721
91	CSK	0.21744661
92	ICK	0.21213346
93	PIK3CG	0.21017273
94	RET	0.20739905
95	ILK	0.20182708
96	DMPK	0.19817550
97	ZAP70	0.19641484
98	MAPKAPK2	0.17064192
99	MAP2K1	0.16659678
100	RPS6KA2	0.15614544

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	5.37091577
2	Vitamin digestion and absorption_Homo sapiens_hsa04977	4.58366752
3	Fat digestion and absorption_Homo sapiens_hsa04975	4.52697078
4	Renin-angiotensin system_Homo sapiens_hsa04614	3.70954192
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.92147016
6	Mineral absorption_Homo sapiens_hsa04978	2.64598503
7	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.50986036
8	Protein digestion and absorption_Homo sapiens_hsa04974	2.31107995
9	Caffeine metabolism_Homo sapiens_hsa00232	2.26245578
10	Sulfur metabolism_Homo sapiens_hsa00920	2.16883395
11	Galactose metabolism_Homo sapiens_hsa00052	2.16097305
12	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.16072712
13	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.15509446
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.13235656
15	Histidine metabolism_Homo sapiens_hsa00340	2.12542013
16	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.93906931
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.91208859
18	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.90608735
19	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.81307370
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77136021
21	PPAR signaling pathway_Homo sapiens_hsa03320	1.77042710
22	Retinol metabolism_Homo sapiens_hsa00830	1.75934957
23	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.75474985
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.69231596
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.68217588
26	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.67466249
27	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.62758517
28	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.60746254
29	Bile secretion_Homo sapiens_hsa04976	1.60366121
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.39199171
31	Arginine and proline metabolism_Homo sapiens_hsa00330	1.37028192
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.35910127
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.28940623
34	Glycerolipid metabolism_Homo sapiens_hsa00561	1.24801254
35	Asthma_Homo sapiens_hsa05310	1.21977889
36	Fatty acid degradation_Homo sapiens_hsa00071	1.21547680
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.21439793
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.21127713
39	Glutathione metabolism_Homo sapiens_hsa00480	1.10682667
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.01915720
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00908269
42	Phenylalanine metabolism_Homo sapiens_hsa00360	0.96367425
43	Ether lipid metabolism_Homo sapiens_hsa00565	0.90981725
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.90756726
45	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.89365714
46	Sulfur relay system_Homo sapiens_hsa04122	0.78110184
47	Pentose phosphate pathway_Homo sapiens_hsa00030	0.73607731
48	Allograft rejection_Homo sapiens_hsa05330	0.72888896
49	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.68168408
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66162076
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.65377082
52	Pancreatic secretion_Homo sapiens_hsa04972	0.65256625
53	Sphingolipid metabolism_Homo sapiens_hsa00600	0.64547285
54	Folate biosynthesis_Homo sapiens_hsa00790	0.64054282
55	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.63857461
56	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.60054628
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.56252714
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.54398526
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.53414401
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53135651
61	Carbon metabolism_Homo sapiens_hsa01200	0.51038656
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.50085568
63	Other glycan degradation_Homo sapiens_hsa00511	0.49549374
64	Peroxisome_Homo sapiens_hsa04146	0.49354595
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.44887291
66	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.38974983
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.37619068
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.33970830
69	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.32130088
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.30068092
71	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.29640645
72	Metabolic pathways_Homo sapiens_hsa01100	0.29157066
73	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.27186679
74	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.26207016
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.25802051
76	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.25759419
77	Renin secretion_Homo sapiens_hsa04924	0.24574923
78	Insulin resistance_Homo sapiens_hsa04931	0.24025025
79	Leishmaniasis_Homo sapiens_hsa05140	0.22138170
80	Hepatitis C_Homo sapiens_hsa05160	0.18994328
81	ABC transporters_Homo sapiens_hsa02010	0.17813828
82	Pertussis_Homo sapiens_hsa05133	0.17327076
83	Fatty acid elongation_Homo sapiens_hsa00062	0.14750369
84	Viral myocarditis_Homo sapiens_hsa05416	0.13740340
85	Glucagon signaling pathway_Homo sapiens_hsa04922	0.12858273
86	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.11596023
87	Tight junction_Homo sapiens_hsa04530	0.10000198
88	Toxoplasmosis_Homo sapiens_hsa05145	0.08863338
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.08757241
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.08328766
91	Butanoate metabolism_Homo sapiens_hsa00650	0.04507042
92	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.02847798
93	Cocaine addiction_Homo sapiens_hsa05030	0.02472151
94	African trypanosomiasis_Homo sapiens_hsa05143	0.01184286
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	-0.0544270
96	GnRH signaling pathway_Homo sapiens_hsa04912	-0.0544114
97	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	-0.0465305
98	Hematopoietic cell lineage_Homo sapiens_hsa04640	-0.0339094
99	Propanoate metabolism_Homo sapiens_hsa00640	-0.0331369
100	Influenza A_Homo sapiens_hsa05164	-0.0127710

C11ORF86

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »