C11ORF88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right pattern formation (GO:0060972)9.07923540
2regulation of cilium movement (GO:0003352)7.68554171
3ventricular system development (GO:0021591)7.37669264
4intraciliary transport (GO:0042073)7.00642063
5left/right axis specification (GO:0070986)6.83549616
6cilium organization (GO:0044782)6.58037943
7cilium assembly (GO:0042384)6.35689085
8microtubule bundle formation (GO:0001578)6.17928820
9primary alcohol catabolic process (GO:0034310)6.01874703
10vitamin transmembrane transport (GO:0035461)5.67718896
11centriole assembly (GO:0098534)5.59463254
12protein localization to cilium (GO:0061512)5.51506047
13ethanol metabolic process (GO:0006067)5.05286364
14cilium morphogenesis (GO:0060271)5.04962858
15cellular component assembly involved in morphogenesis (GO:0010927)5.03986546
16diterpenoid biosynthetic process (GO:0016102)5.03030177
17microtubule-based movement (GO:0007018)4.93082823
18response to xenobiotic stimulus (GO:0009410)4.83110415
19nucleoside diphosphate phosphorylation (GO:0006165)4.74027778
20pyrimidine-containing compound transmembrane transport (GO:0072531)4.71202739
21tolerance induction (GO:0002507)4.66691371
22regulation of microtubule-based movement (GO:0060632)4.65645534
23negative regulation of T cell differentiation in thymus (GO:0033085)4.65504175
24cell projection assembly (GO:0030031)4.48054196
25one-carbon compound transport (GO:0019755)4.47699609
26sperm capacitation (GO:0048240)4.42429264
27lung epithelium development (GO:0060428)4.26712180
28centriole replication (GO:0007099)4.10234558
29glomerular epithelial cell development (GO:0072310)3.94922886
30lateral ventricle development (GO:0021670)3.92272686
31terpenoid biosynthetic process (GO:0016114)3.81605943
32determination of left/right symmetry (GO:0007368)3.79363692
33sperm motility (GO:0030317)3.78965475
34negative regulation of immunoglobulin mediated immune response (GO:0002890)3.75320096
35negative regulation of B cell mediated immunity (GO:0002713)3.75320096
36establishment of apical/basal cell polarity (GO:0035089)3.71854612
37retinoic acid metabolic process (GO:0042573)3.67497717
38regulation of interleukin-5 production (GO:0032674)3.62561944
39ethanol oxidation (GO:0006069)3.61697361
40determination of bilateral symmetry (GO:0009855)3.60707379
41exogenous drug catabolic process (GO:0042738)3.59091719
42regulation of germinal center formation (GO:0002634)3.56506029
43specification of symmetry (GO:0009799)3.54433816
44establishment or maintenance of monopolar cell polarity (GO:0061339)3.48729318
45establishment of monopolar cell polarity (GO:0061162)3.48729318
46negative regulation of humoral immune response (GO:0002921)3.46237360
47smoothened signaling pathway (GO:0007224)3.39361151
48cytoplasmic microtubule organization (GO:0031122)3.33697437
49microtubule depolymerization (GO:0007019)3.31518288
50positive regulation of tolerance induction (GO:0002645)3.31075729
51glutathione derivative biosynthetic process (GO:1901687)3.23725076
52glutathione derivative metabolic process (GO:1901685)3.23725076
53retinol metabolic process (GO:0042572)3.11246331
54establishment of planar polarity (GO:0001736)3.09014009
55establishment of tissue polarity (GO:0007164)3.09014009
56primary alcohol metabolic process (GO:0034308)3.03994342
57regulation of interleukin-13 production (GO:0032656)3.02540715
58microtubule polymerization or depolymerization (GO:0031109)3.01342439
59axonemal dynein complex assembly (GO:0070286)22.0239034
60drug catabolic process (GO:0042737)2.92158921
61GTP biosynthetic process (GO:0006183)2.87101704
62microtubule-based process (GO:0007017)2.86392459
63hydrogen peroxide biosynthetic process (GO:0050665)2.85295501
64aldehyde catabolic process (GO:0046185)2.85211718
65negative regulation of inclusion body assembly (GO:0090084)2.83787162
66retinal rod cell development (GO:0046548)2.81782323
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81195601
68organelle assembly (GO:0070925)2.81123970
69nonmotile primary cilium assembly (GO:0035058)2.73356999
70positive regulation of smoothened signaling pathway (GO:0045880)2.64566679
71O-glycan processing (GO:0016266)2.64205083
72phenol-containing compound catabolic process (GO:0019336)2.62764345
73photoreceptor cell maintenance (GO:0045494)2.62544475
74lateral sprouting from an epithelium (GO:0060601)2.62011359
75nucleotide phosphorylation (GO:0046939)2.59805402
76reactive oxygen species biosynthetic process (GO:1903409)2.59161821
77regulation of autophagic vacuole assembly (GO:2000785)2.54915726
78intra-S DNA damage checkpoint (GO:0031573)2.53857912
79phosphatidylcholine biosynthetic process (GO:0006656)2.49545414
80heart looping (GO:0001947)2.49450849
81nucleoside diphosphate metabolic process (GO:0009132)2.48492000
82excretion (GO:0007588)2.42987742
83regulation of collateral sprouting (GO:0048670)2.41742013
84regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.37714659
85carnitine metabolic process (GO:0009437)2.37370160
86retinal cone cell development (GO:0046549)2.36337605
87UTP biosynthetic process (GO:0006228)2.35474020
88cornea development in camera-type eye (GO:0061303)2.31698199
89regulation of tolerance induction (GO:0002643)2.31603589
90oligosaccharide biosynthetic process (GO:0009312)2.27705922
91regulation of microtubule depolymerization (GO:0031114)2.24088190
92embryonic heart tube morphogenesis (GO:0003143)2.24014384
93sialylation (GO:0097503)2.21440075
94multicellular organismal water homeostasis (GO:0050891)2.20716937
95cilium or flagellum-dependent cell motility (GO:0001539)17.8492157
96cilium movement (GO:0003341)16.9122215
97epithelial cilium movement (GO:0003351)15.4627419
98motile cilium assembly (GO:0044458)15.0830279
99epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)15.0036689
100axoneme assembly (GO:0035082)10.6157770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.43217438
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.89425098
3DROSHA_22980978_ChIP-Seq_HELA_Human2.96806682
4FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.72917637
5VDR_22108803_ChIP-Seq_LS180_Human2.59563146
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.20245500
7PIAS1_25552417_ChIP-Seq_VCAP_Human2.10112983
8NR3C1_21868756_ChIP-Seq_MCF10A_Human1.80997538
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72262698
10FOXM1_26456572_ChIP-Seq_MCF-7_Human1.69199915
11AHR_22903824_ChIP-Seq_MCF-7_Human1.68891664
12STAT1_20625510_ChIP-Seq_HELA_Human1.68519140
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60572014
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58233094
15TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56844556
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51525946
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.51436350
18ARNT_22903824_ChIP-Seq_MCF-7_Human1.48096000
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.47492554
20BCAT_22108803_ChIP-Seq_LS180_Human1.45730276
21ETV1_20927104_ChIP-Seq_GIST48_Human1.45231203
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44259954
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44024561
24TP63_23658742_ChIP-Seq_EP156T_Human1.43592400
25SMAD4_21799915_ChIP-Seq_A2780_Human1.43416457
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40233245
27FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.40043984
28PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38401326
29ZNF274_21170338_ChIP-Seq_K562_Hela1.37138775
30PHF8_20622853_ChIP-Seq_HELA_Human1.36650731
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36514840
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35867918
33SMRT_27268052_Chip-Seq_Bcells_Human1.35784056
34TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.33174126
35TCF4_22108803_ChIP-Seq_LS180_Human1.33161757
36PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.32648325
37AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.30678854
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.30082410
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29970521
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28318646
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.28318646
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27722828
43ER_23166858_ChIP-Seq_MCF-7_Human1.27681535
44CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26162337
45HNFA_21074721_ChIP-Seq_CACO-2_Human1.25630734
46SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25528283
47TP53_18474530_ChIP-ChIP_U2OS_Human1.21999042
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21960815
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21960815
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21328277
51RBPJ_21746931_ChIP-Seq_IB4_Human1.20528525
52STAT3_23295773_ChIP-Seq_U87_Human1.19421292
53AR_20517297_ChIP-Seq_VCAP_Human1.18263537
54RAD21_21589869_ChIP-Seq_MESCs_Mouse1.18081791
55FOXA1_25552417_ChIP-Seq_VCAP_Human1.17486300
56ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17102319
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.13388060
58TBL1_22424771_ChIP-Seq_293T_Human1.13308015
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.13213220
60NFYA_21822215_ChIP-Seq_K562_Human1.12762407
61RUNX1_27514584_Chip-Seq_MCF-7_Human1.11398603
62CBX2_22325352_ChIP-Seq_293T-Rex_Human1.11376986
63NFYB_21822215_ChIP-Seq_K562_Human1.09284912
64SMC4_20622854_ChIP-Seq_HELA_Human1.09271631
65GATA6_21074721_ChIP-Seq_CACO-2_Human1.09222952
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.09184870
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09016961
68TP63_22573176_ChIP-Seq_HFKS_Human1.08544076
69AR_21572438_ChIP-Seq_LNCaP_Human1.08320387
70CBP_20019798_ChIP-Seq_JUKART_Human1.07437657
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07437657
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.07270092
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07247915
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06970469
75FUS_26573619_Chip-Seq_HEK293_Human1.06303741
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.05944807
77CEBPB_22108803_ChIP-Seq_LS180_Human1.05454664
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04452859
79TCF4_23295773_ChIP-Seq_U87_Human1.04096565
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03768839
81YY1_22570637_ChIP-Seq_MALME-3M_Human1.03747786
82ERG_20517297_ChIP-Seq_VCAP_Human1.02959148
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.01242005
84CTCF_20526341_ChIP-Seq_ESCs_Human1.01224036
85RUNX2_22187159_ChIP-Seq_PCA_Human1.01100284
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00918031
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00674199
88P300_19829295_ChIP-Seq_ESCs_Human1.00519898
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00498792
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.00487060
91MYC_19829295_ChIP-Seq_ESCs_Human1.00217978
92GATA4_25053715_ChIP-Seq_YYC3_Human0.99971494
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99561659
94KLF5_25053715_ChIP-Seq_YYC3_Human0.98752772
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98275664
96EWS_26573619_Chip-Seq_HEK293_Human0.98171019
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97312428
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95979099
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.95726425
100RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95667793

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.85495275
2MP0008875_abnormal_xenobiotic_pharmacok6.24742856
3MP0002132_abnormal_respiratory_system4.31914581
4MP0001984_abnormal_olfaction4.15854755
5MP0004133_heterotaxia3.85996080
6MP0004043_abnormal_pH_regulation3.79289732
7MP0002277_abnormal_respiratory_mucosa3.47725703
8MP0000566_synostosis2.91025976
9MP0005623_abnormal_meninges_morphology2.86910633
10MP0005377_hearing/vestibular/ear_phenot2.86502921
11MP0003878_abnormal_ear_physiology2.86502921
12MP0008789_abnormal_olfactory_epithelium2.68490263
13MP0003136_yellow_coat_color2.59882141
14MP0009780_abnormal_chondrocyte_physiolo2.42128480
15MP0004019_abnormal_vitamin_homeostasis2.23528367
16MP0002160_abnormal_reproductive_system2.23442909
17MP0002282_abnormal_trachea_morphology2.09568735
18MP0000383_abnormal_hair_follicle2.00511217
19MP0005394_taste/olfaction_phenotype1.77901967
20MP0005499_abnormal_olfactory_system1.77901967
21MP0001485_abnormal_pinna_reflex1.65511741
22MP0002876_abnormal_thyroid_physiology1.61109454
23MP0009046_muscle_twitch1.57695850
24MP0005083_abnormal_biliary_tract1.57307746
25MP0001765_abnormal_ion_homeostasis1.56409509
26MP0002638_abnormal_pupillary_reflex1.54729387
27MP0002734_abnormal_mechanical_nocicepti1.51160925
28MP0003806_abnormal_nucleotide_metabolis1.46895613
29MP0002909_abnormal_adrenal_gland1.45973373
30MP0002168_other_aberrant_phenotype1.42038807
31MP0010678_abnormal_skin_adnexa1.41150409
32MP0005551_abnormal_eye_electrophysiolog1.34133206
33MP0005389_reproductive_system_phenotype1.29292784
34MP0005253_abnormal_eye_physiology1.25475289
35MP0009379_abnormal_foot_pigmentation1.21295914
36MP0003195_calcinosis1.14608164
37MP0003656_abnormal_erythrocyte_physiolo1.12942757
38MP0001346_abnormal_lacrimal_gland1.12180003
39MP0005365_abnormal_bile_salt1.10549795
40MP0002928_abnormal_bile_duct1.06005144
41MP0005636_abnormal_mineral_homeostasis1.04722207
42MP0005408_hypopigmentation1.04466290
43MP0000026_abnormal_inner_ear1.02844221
44MP0001324_abnormal_eye_pigmentation1.02823267
45MP0001502_abnormal_circadian_rhythm1.02433277
46MP0003698_abnormal_male_reproductive1.01028946
47MP0005085_abnormal_gallbladder_physiolo1.00735435
48MP0002735_abnormal_chemical_nociception1.00641287
49MP0001929_abnormal_gametogenesis0.98751542
50MP0002233_abnormal_nose_morphology0.94351701
51MP0004885_abnormal_endolymph0.93907438
52MP0005395_other_phenotype0.93613261
53MP0009745_abnormal_behavioral_response0.91857437
54MP0008872_abnormal_physiological_respon0.90023034
55MP0010030_abnormal_orbit_morphology0.86268214
56MP0001970_abnormal_pain_threshold0.86001714
57MP0001293_anophthalmia0.84711551
58MP0005165_increased_susceptibility_to0.84697721
59MP0001486_abnormal_startle_reflex0.80573161
60MP0006072_abnormal_retinal_apoptosis0.79449765
61MP0005195_abnormal_posterior_eye0.78182014
62MP0001963_abnormal_hearing_physiology0.76754924
63MP0002249_abnormal_larynx_morphology0.76648231
64MP0003938_abnormal_ear_development0.74837394
65MP0009643_abnormal_urine_homeostasis0.74587306
66MP0002136_abnormal_kidney_physiology0.71778400
67MP0003937_abnormal_limbs/digits/tail_de0.71666875
68MP0005503_abnormal_tendon_morphology0.70270940
69MP0002272_abnormal_nervous_system0.69576523
70MP0001188_hyperpigmentation0.68447897
71MP0002822_catalepsy0.67914769
72MP0006036_abnormal_mitochondrial_physio0.67562568
73MP0003283_abnormal_digestive_organ0.67317454
74MP0003890_abnormal_embryonic-extraembry0.65077725
75MP0005220_abnormal_exocrine_pancreas0.64766310
76MP0002229_neurodegeneration0.63331348
77MP0005391_vision/eye_phenotype0.63024858
78MP0002102_abnormal_ear_morphology0.62497471
79MP0001944_abnormal_pancreas_morphology0.62135850
80MP0002572_abnormal_emotion/affect_behav0.61158991
81MP0010155_abnormal_intestine_physiology0.61148656
82MP0000678_abnormal_parathyroid_gland0.59696664
83MP0005646_abnormal_pituitary_gland0.59014622
84MP0005310_abnormal_salivary_gland0.58941780
85MP0009765_abnormal_xenobiotic_induced0.58538990
86MP0005248_abnormal_Harderian_gland0.58323771
87MP0000631_abnormal_neuroendocrine_gland0.57985761
88MP0003879_abnormal_hair_cell0.57920421
89MP0001663_abnormal_digestive_system0.56477849
90MP0000465_gastrointestinal_hemorrhage0.55705809
91MP0001905_abnormal_dopamine_level0.55631429
92MP0008995_early_reproductive_senescence0.54729449
93MP0002557_abnormal_social/conspecific_i0.54398471
94MP0001664_abnormal_digestion0.53753059
95MP0006276_abnormal_autonomic_nervous0.53505540
96MP0000955_abnormal_spinal_cord0.53410055
97MP0000049_abnormal_middle_ear0.51001058
98MP0002752_abnormal_somatic_nervous0.49735998
99MP0002098_abnormal_vibrissa_morphology0.48413512
100MP0005164_abnormal_response_to0.47158052

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.82983612
2Chronic bronchitis (HP:0004469)7.52189974
3Bronchiectasis (HP:0002110)7.20946166
4Nasal polyposis (HP:0100582)6.41652357
5Abnormality of the nasal mucosa (HP:0000433)5.29784235
6Chronic sinusitis (HP:0011109)4.26682644
7Bronchitis (HP:0012387)4.20106770
8Infertility (HP:0000789)4.18869085
9Recurrent sinusitis (HP:0011108)4.11179494
10Pancreatic fibrosis (HP:0100732)4.07396042
11True hermaphroditism (HP:0010459)4.05219325
12Occipital encephalocele (HP:0002085)4.01158842
13Molar tooth sign on MRI (HP:0002419)3.66977494
14Abnormality of midbrain morphology (HP:0002418)3.66977494
15Recurrent otitis media (HP:0000403)3.59226696
16Pancreatic cysts (HP:0001737)3.54714255
17Nephronophthisis (HP:0000090)3.42742136
18Cystic liver disease (HP:0006706)3.27865795
19Male infertility (HP:0003251)3.20031923
20Chronic hepatic failure (HP:0100626)2.98405166
21Chronic otitis media (HP:0000389)2.95496963
22Atelectasis (HP:0100750)2.72404179
23Abnormality of the renal medulla (HP:0100957)2.65999211
24Postaxial foot polydactyly (HP:0001830)2.57943247
25Hyperactive renin-angiotensin system (HP:0000841)2.51551169
26Medial flaring of the eyebrow (HP:0010747)2.44141766
27Congenital hepatic fibrosis (HP:0002612)2.41410217
28Tubular atrophy (HP:0000092)2.35908312
29Anencephaly (HP:0002323)2.35555237
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.32467980
31Tubulointerstitial nephritis (HP:0001970)2.22988933
32Male pseudohermaphroditism (HP:0000037)2.22048387
33Sclerocornea (HP:0000647)2.10292877
34Furrowed tongue (HP:0000221)2.07771972
35Gait imbalance (HP:0002141)2.06464913
36Congenital primary aphakia (HP:0007707)2.05063947
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.0904651
38Abnormal respiratory motile cilium physiology (HP:0012261)10.9907480
39Abnormal respiratory motile cilium morphology (HP:0005938)10.9355751
40Abnormal respiratory epithelium morphology (HP:0012253)10.9355751
41Abnormal ciliary motility (HP:0012262)10.8282939
42Dynein arm defect of respiratory motile cilia (HP:0012255)10.6433182
43Absent/shortened dynein arms (HP:0200106)10.6433182
44Recurrent bronchitis (HP:0002837)1.91799567
45Asplenia (HP:0001746)1.90475472
46Aplasia/Hypoplasia of the spleen (HP:0010451)1.90328463
47Decreased circulating renin level (HP:0003351)1.87606630
48Oculomotor apraxia (HP:0000657)1.86683910
49Nephrogenic diabetes insipidus (HP:0009806)1.80675762
50Postaxial hand polydactyly (HP:0001162)1.78288705
51Bell-shaped thorax (HP:0001591)1.65841513
52Nephropathy (HP:0000112)1.64159021
53Renal salt wasting (HP:0000127)1.58023445
54Polydipsia (HP:0001959)1.55026667
55Abnormal drinking behavior (HP:0030082)1.55026667
56Preaxial hand polydactyly (HP:0001177)1.54612116
57Absent rod-and cone-mediated responses on ERG (HP:0007688)1.53376342
58Tubulointerstitial abnormality (HP:0001969)1.53024789
59Vaginal atresia (HP:0000148)1.48722190
60Genital tract atresia (HP:0001827)1.47287863
61Absent frontal sinuses (HP:0002688)1.47236689
62Abnormality of the renal cortex (HP:0011035)1.46956260
63Decreased central vision (HP:0007663)1.42354278
64Poor coordination (HP:0002370)1.42271783
65Abnormal biliary tract physiology (HP:0012439)1.40006661
66Bile duct proliferation (HP:0001408)1.40006661
67Stage 5 chronic kidney disease (HP:0003774)1.39201392
68Median cleft lip (HP:0000161)1.38838126
69Hyperkalemia (HP:0002153)1.34958852
70Abnormality of renin-angiotensin system (HP:0000847)1.33339899
71Supernumerary spleens (HP:0009799)1.32924016
72Hyperaldosteronism (HP:0000859)1.32809341
73Short nail (HP:0001799)1.28515995
74Tubulointerstitial fibrosis (HP:0005576)1.25809557
75Abnormality of permanent molar morphology (HP:0011071)1.24587381
76Abnormality of the dental root (HP:0006486)1.24587381
77Taurodontia (HP:0000679)1.24587381
78Abnormal rod and cone electroretinograms (HP:0008323)1.19889809
79Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.18892223
80Abnormality of chloride homeostasis (HP:0011422)1.16931980
81Abnormality of molar morphology (HP:0011070)1.14584233
82Abnormality of molar (HP:0011077)1.14584233
83Narrow forehead (HP:0000341)1.14582167
84Retinitis pigmentosa (HP:0000510)1.13262324
85Abnormality of abdominal situs (HP:0011620)1.12851998
86Abdominal situs inversus (HP:0003363)1.12851998
87Absent speech (HP:0001344)1.12478632
88Hypokalemic alkalosis (HP:0001949)1.12362291
89Abnormality of the dental pulp (HP:0006479)1.12020018
90Abnormality of dentin (HP:0010299)1.10486861
91Abnormality of macular pigmentation (HP:0008002)1.06820684
92Short thorax (HP:0010306)1.06708942
93Aganglionic megacolon (HP:0002251)1.06452399
94Prominent nasal bridge (HP:0000426)1.05765129
95Polyuria (HP:0000103)1.04976637
96Multicystic kidney dysplasia (HP:0000003)1.03289847
97Abnormality of the frontal sinuses (HP:0002687)1.01330924
98Cone-rod dystrophy (HP:0000548)1.00880550
99Optic nerve coloboma (HP:0000588)1.00269157
100Nonprogressive disorder (HP:0003680)0.98137924

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST45.11152795
2EPHA23.46227130
3MAPKAPK32.63338810
4PTK2B2.18510446
5TLK12.13285977
6MAPK1511.6071744
7PNCK1.99681115
8NME11.84747207
9MAP3K21.64915754
10STK241.64901029
11FRK1.45234963
12BCR1.43256474
13ADRBK21.41646762
14STK161.39523815
15GRK11.26920676
16PINK11.24201937
17WNK31.21548653
18TTK1.21331009
19WNK41.18048435
20MAP3K41.14510503
21CSK1.10539508
22CCNB11.04776175
23MAP3K31.04175173
24TRPM71.01706606
25PRKCI1.01543177
26MUSK1.00519478
27MAP3K120.99164685
28NEK60.90753200
29EEF2K0.86576541
30STK38L0.86563260
31INSRR0.84119657
32BMPR1B0.80714253
33MAP2K70.76731966
34MAP3K70.76249349
35CAMKK10.75526977
36LATS10.75463742
37LRRK20.74405037
38CAMKK20.74289495
39STK390.73926578
40STK380.70126122
41PRKCQ0.69917672
42TSSK60.69731529
43GRK60.69730738
44ADRBK10.68050498
45MAP4K20.67463490
46BRSK20.65181195
47SMG10.64760288
48ERBB30.63185679
49EPHA30.62310898
50MAPK130.59333348
51ERBB20.58909123
52TXK0.57833020
53STK100.56348999
54EPHB10.55889821
55OXSR10.55717156
56MARK20.55467060
57MAP2K40.54859210
58ACVR1B0.51183451
59AURKA0.47170360
60MAPKAPK50.43114833
61PASK0.41468273
62NLK0.41405685
63TBK10.41012024
64DYRK30.39114044
65PRKACA0.38815181
66PRKCD0.38601839
67CAMK2G0.37844263
68SGK10.36974809
69WEE10.35823232
70CAMK2A0.35720091
71DYRK1A0.34829290
72MST1R0.34216878
73NEK20.33998338
74PRKCE0.32307486
75MAP2K60.29527065
76MAP2K20.29276404
77PRKCA0.29195454
78TAOK10.29115038
79ITK0.28185620
80TIE10.28148204
81PRKCG0.27083175
82CHUK0.25514823
83IRAK10.24592259
84TEC0.23377425
85CDK80.22867363
86PRKG10.22294387
87PHKG20.22058880
88PHKG10.22058880
89PRKAA20.21436178
90PLK10.21060344
91RPS6KB20.20802882
92CDK190.20712366
93ABL10.20266378
94DYRK20.19980814
95CSNK1G20.18631358
96HIPK20.18325315
97SGK2230.17704409
98SGK4940.17704409
99AKT20.17527061
100MYLK0.16811445

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009805.06471316
2Chemical carcinogenesis_Homo sapiens_hsa052044.24559739
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009824.04651066
4Histidine metabolism_Homo sapiens_hsa003403.89257645
5Phenylalanine metabolism_Homo sapiens_hsa003603.84243969
6Huntingtons disease_Homo sapiens_hsa050163.35710458
7Tyrosine metabolism_Homo sapiens_hsa003503.05572818
8beta-Alanine metabolism_Homo sapiens_hsa004102.64127946
9Caffeine metabolism_Homo sapiens_hsa002322.51853643
10Linoleic acid metabolism_Homo sapiens_hsa005912.39544164
11Glutathione metabolism_Homo sapiens_hsa004802.39469299
12Retinol metabolism_Homo sapiens_hsa008302.32163179
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00097948
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73655695
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.64470573
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62679691
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.62524776
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44915578
19ABC transporters_Homo sapiens_hsa020101.40482940
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39019802
21Peroxisome_Homo sapiens_hsa041461.35576938
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30025780
23Nicotine addiction_Homo sapiens_hsa050331.23565723
24Phototransduction_Homo sapiens_hsa047441.23270488
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21925426
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19465114
27Oxidative phosphorylation_Homo sapiens_hsa001901.19406672
28Sphingolipid metabolism_Homo sapiens_hsa006001.19294866
29Fatty acid degradation_Homo sapiens_hsa000711.12245758
30Nitrogen metabolism_Homo sapiens_hsa009101.12077873
31Arachidonic acid metabolism_Homo sapiens_hsa005901.11112925
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09939347
33Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06606665
34Salivary secretion_Homo sapiens_hsa049701.05663015
35Tight junction_Homo sapiens_hsa045301.05608017
36Olfactory transduction_Homo sapiens_hsa047401.01637126
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00462364
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99213440
39Butanoate metabolism_Homo sapiens_hsa006500.98133896
40Taste transduction_Homo sapiens_hsa047420.96446400
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.87572525
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86974094
43Cardiac muscle contraction_Homo sapiens_hsa042600.84427606
44Collecting duct acid secretion_Homo sapiens_hsa049660.81618915
45Hedgehog signaling pathway_Homo sapiens_hsa043400.78531744
46Tryptophan metabolism_Homo sapiens_hsa003800.74465458
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.74319460
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74122504
49Circadian rhythm_Homo sapiens_hsa047100.73990140
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71670745
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70996867
52Starch and sucrose metabolism_Homo sapiens_hsa005000.68355147
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.68158785
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68032425
55Alzheimers disease_Homo sapiens_hsa050100.64727407
56Parkinsons disease_Homo sapiens_hsa050120.64091185
57Serotonergic synapse_Homo sapiens_hsa047260.62796284
58Basal cell carcinoma_Homo sapiens_hsa052170.61596348
59Metabolic pathways_Homo sapiens_hsa011000.58190336
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.56223707
61Drug metabolism - other enzymes_Homo sapiens_hsa009830.56026519
62Vitamin digestion and absorption_Homo sapiens_hsa049770.44655754
63Asthma_Homo sapiens_hsa053100.43485643
64Ether lipid metabolism_Homo sapiens_hsa005650.42297819
65Calcium signaling pathway_Homo sapiens_hsa040200.41955797
66Glycerolipid metabolism_Homo sapiens_hsa005610.39757561
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39009814
68Arginine and proline metabolism_Homo sapiens_hsa003300.38773873
69Regulation of autophagy_Homo sapiens_hsa041400.38743610
70Hematopoietic cell lineage_Homo sapiens_hsa046400.38264097
71Type I diabetes mellitus_Homo sapiens_hsa049400.37899553
72PPAR signaling pathway_Homo sapiens_hsa033200.34677079
73cAMP signaling pathway_Homo sapiens_hsa040240.34655733
74Allograft rejection_Homo sapiens_hsa053300.34638985
75Autoimmune thyroid disease_Homo sapiens_hsa053200.33037841
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31031847
77Cocaine addiction_Homo sapiens_hsa050300.30120773
78Graft-versus-host disease_Homo sapiens_hsa053320.30089568
79Nucleotide excision repair_Homo sapiens_hsa034200.29994027
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29528804
81Ovarian steroidogenesis_Homo sapiens_hsa049130.29486001
82Protein export_Homo sapiens_hsa030600.28483880
83Hippo signaling pathway_Homo sapiens_hsa043900.28122301
84Purine metabolism_Homo sapiens_hsa002300.28061133
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27847808
86Notch signaling pathway_Homo sapiens_hsa043300.27186529
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.25979596
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25605280
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.25572195
90Propanoate metabolism_Homo sapiens_hsa006400.25128386
91Glutamatergic synapse_Homo sapiens_hsa047240.24262981
92Mineral absorption_Homo sapiens_hsa049780.21786347
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21641943
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17009188
95Pancreatic secretion_Homo sapiens_hsa049720.15920908
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.15246181
97Amphetamine addiction_Homo sapiens_hsa050310.14737587
98Choline metabolism in cancer_Homo sapiens_hsa052310.13901564
99Complement and coagulation cascades_Homo sapiens_hsa046100.13645085
100Basal transcription factors_Homo sapiens_hsa030220.13083593

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