ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	9.07923540
2	regulation of cilium movement (GO:0003352)	7.68554171
3	ventricular system development (GO:0021591)	7.37669264
4	intraciliary transport (GO:0042073)	7.00642063
5	left/right axis specification (GO:0070986)	6.83549616
6	cilium organization (GO:0044782)	6.58037943
7	cilium assembly (GO:0042384)	6.35689085
8	microtubule bundle formation (GO:0001578)	6.17928820
9	primary alcohol catabolic process (GO:0034310)	6.01874703
10	vitamin transmembrane transport (GO:0035461)	5.67718896
11	centriole assembly (GO:0098534)	5.59463254
12	protein localization to cilium (GO:0061512)	5.51506047
13	ethanol metabolic process (GO:0006067)	5.05286364
14	cilium morphogenesis (GO:0060271)	5.04962858
15	cellular component assembly involved in morphogenesis (GO:0010927)	5.03986546
16	diterpenoid biosynthetic process (GO:0016102)	5.03030177
17	microtubule-based movement (GO:0007018)	4.93082823
18	response to xenobiotic stimulus (GO:0009410)	4.83110415
19	nucleoside diphosphate phosphorylation (GO:0006165)	4.74027778
20	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.71202739
21	tolerance induction (GO:0002507)	4.66691371
22	regulation of microtubule-based movement (GO:0060632)	4.65645534
23	negative regulation of T cell differentiation in thymus (GO:0033085)	4.65504175
24	cell projection assembly (GO:0030031)	4.48054196
25	one-carbon compound transport (GO:0019755)	4.47699609
26	sperm capacitation (GO:0048240)	4.42429264
27	lung epithelium development (GO:0060428)	4.26712180
28	centriole replication (GO:0007099)	4.10234558
29	glomerular epithelial cell development (GO:0072310)	3.94922886
30	lateral ventricle development (GO:0021670)	3.92272686
31	terpenoid biosynthetic process (GO:0016114)	3.81605943
32	determination of left/right symmetry (GO:0007368)	3.79363692
33	sperm motility (GO:0030317)	3.78965475
34	negative regulation of B cell mediated immunity (GO:0002713)	3.75320096
35	negative regulation of immunoglobulin mediated immune response (GO:0002890)	3.75320096
36	establishment of apical/basal cell polarity (GO:0035089)	3.71854612
37	retinoic acid metabolic process (GO:0042573)	3.67497717
38	regulation of interleukin-5 production (GO:0032674)	3.62561944
39	ethanol oxidation (GO:0006069)	3.61697361
40	determination of bilateral symmetry (GO:0009855)	3.60707379
41	exogenous drug catabolic process (GO:0042738)	3.59091719
42	regulation of germinal center formation (GO:0002634)	3.56506029
43	specification of symmetry (GO:0009799)	3.54433816
44	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.48729318
45	establishment of monopolar cell polarity (GO:0061162)	3.48729318
46	negative regulation of humoral immune response (GO:0002921)	3.46237360
47	smoothened signaling pathway (GO:0007224)	3.39361151
48	cytoplasmic microtubule organization (GO:0031122)	3.33697437
49	microtubule depolymerization (GO:0007019)	3.31518288
50	positive regulation of tolerance induction (GO:0002645)	3.31075729
51	glutathione derivative metabolic process (GO:1901685)	3.23725076
52	glutathione derivative biosynthetic process (GO:1901687)	3.23725076
53	retinol metabolic process (GO:0042572)	3.11246331
54	establishment of tissue polarity (GO:0007164)	3.09014009
55	establishment of planar polarity (GO:0001736)	3.09014009
56	primary alcohol metabolic process (GO:0034308)	3.03994342
57	regulation of interleukin-13 production (GO:0032656)	3.02540715
58	microtubule polymerization or depolymerization (GO:0031109)	3.01342439
59	axonemal dynein complex assembly (GO:0070286)	22.0239034
60	drug catabolic process (GO:0042737)	2.92158921
61	GTP biosynthetic process (GO:0006183)	2.87101704
62	microtubule-based process (GO:0007017)	2.86392459
63	hydrogen peroxide biosynthetic process (GO:0050665)	2.85295501
64	aldehyde catabolic process (GO:0046185)	2.85211718
65	negative regulation of inclusion body assembly (GO:0090084)	2.83787162
66	retinal rod cell development (GO:0046548)	2.81782323
67	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	2.81195601
68	organelle assembly (GO:0070925)	2.81123970
69	nonmotile primary cilium assembly (GO:0035058)	2.73356999
70	positive regulation of smoothened signaling pathway (GO:0045880)	2.64566679
71	O-glycan processing (GO:0016266)	2.64205083
72	phenol-containing compound catabolic process (GO:0019336)	2.62764345
73	photoreceptor cell maintenance (GO:0045494)	2.62544475
74	lateral sprouting from an epithelium (GO:0060601)	2.62011359
75	nucleotide phosphorylation (GO:0046939)	2.59805402
76	reactive oxygen species biosynthetic process (GO:1903409)	2.59161821
77	regulation of autophagic vacuole assembly (GO:2000785)	2.54915726
78	intra-S DNA damage checkpoint (GO:0031573)	2.53857912
79	phosphatidylcholine biosynthetic process (GO:0006656)	2.49545414
80	heart looping (GO:0001947)	2.49450849
81	nucleoside diphosphate metabolic process (GO:0009132)	2.48492000
82	excretion (GO:0007588)	2.42987742
83	regulation of collateral sprouting (GO:0048670)	2.41742013
84	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.37714659
85	carnitine metabolic process (GO:0009437)	2.37370160
86	retinal cone cell development (GO:0046549)	2.36337605
87	UTP biosynthetic process (GO:0006228)	2.35474020
88	cornea development in camera-type eye (GO:0061303)	2.31698199
89	regulation of tolerance induction (GO:0002643)	2.31603589
90	oligosaccharide biosynthetic process (GO:0009312)	2.27705922
91	regulation of microtubule depolymerization (GO:0031114)	2.24088190
92	embryonic heart tube morphogenesis (GO:0003143)	2.24014384
93	sialylation (GO:0097503)	2.21440075
94	multicellular organismal water homeostasis (GO:0050891)	2.20716937
95	cilium or flagellum-dependent cell motility (GO:0001539)	17.8492157
96	cilium movement (GO:0003341)	16.9122215
97	epithelial cilium movement (GO:0003351)	15.4627419
98	motile cilium assembly (GO:0044458)	15.0830279
99	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	15.0036689
100	axoneme assembly (GO:0035082)	10.6157770

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.43217438
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.89425098
3	DROSHA_22980978_ChIP-Seq_HELA_Human	2.96806682
4	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	2.72917637
5	VDR_22108803_ChIP-Seq_LS180_Human	2.59563146
6	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.20245500
7	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.10112983
8	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.80997538
9	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.72262698
10	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.69199915
11	AHR_22903824_ChIP-Seq_MCF-7_Human	1.68891664
12	STAT1_20625510_ChIP-Seq_HELA_Human	1.68519140
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.60572014
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.58233094
15	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.56844556
16	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.51525946
17	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.51436350
18	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.48096000
19	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.47492554
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.45730276
21	ETV1_20927104_ChIP-Seq_GIST48_Human	1.45231203
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44259954
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.44024561
24	TP63_23658742_ChIP-Seq_EP156T_Human	1.43592400
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43416457
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40233245
27	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.40043984
28	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.38401326
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.37138775
30	PHF8_20622853_ChIP-Seq_HELA_Human	1.36650731
31	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.36514840
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.35867918
33	SMRT_27268052_Chip-Seq_Bcells_Human	1.35784056
34	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.33174126
35	TCF4_22108803_ChIP-Seq_LS180_Human	1.33161757
36	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.32648325
37	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.30678854
38	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.30082410
39	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.29970521
40	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28318646
41	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28318646
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27722828
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.27681535
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.26162337
45	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.25630734
46	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.25528283
47	TP53_18474530_ChIP-ChIP_U2OS_Human	1.21999042
48	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21960815
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21960815
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21328277
51	RBPJ_21746931_ChIP-Seq_IB4_Human	1.20528525
52	STAT3_23295773_ChIP-Seq_U87_Human	1.19421292
53	AR_20517297_ChIP-Seq_VCAP_Human	1.18263537
54	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.18081791
55	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.17486300
56	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.17102319
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13388060
58	TBL1_22424771_ChIP-Seq_293T_Human	1.13308015
59	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.13213220
60	NFYA_21822215_ChIP-Seq_K562_Human	1.12762407
61	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.11398603
62	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.11376986
63	NFYB_21822215_ChIP-Seq_K562_Human	1.09284912
64	SMC4_20622854_ChIP-Seq_HELA_Human	1.09271631
65	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.09222952
66	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.09184870
67	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.09016961
68	TP63_22573176_ChIP-Seq_HFKS_Human	1.08544076
69	AR_21572438_ChIP-Seq_LNCaP_Human	1.08320387
70	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.07437657
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.07437657
72	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07270092
73	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.07247915
74	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.06970469
75	FUS_26573619_Chip-Seq_HEK293_Human	1.06303741
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.05944807
77	CEBPB_22108803_ChIP-Seq_LS180_Human	1.05454664
78	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04452859
79	TCF4_23295773_ChIP-Seq_U87_Human	1.04096565
80	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.03768839
81	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03747786
82	ERG_20517297_ChIP-Seq_VCAP_Human	1.02959148
83	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.01242005
84	CTCF_20526341_ChIP-Seq_ESCs_Human	1.01224036
85	RUNX2_22187159_ChIP-Seq_PCA_Human	1.01100284
86	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.00918031
87	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.00674199
88	P300_19829295_ChIP-Seq_ESCs_Human	1.00519898
89	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00498792
90	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.00487060
91	MYC_19829295_ChIP-Seq_ESCs_Human	1.00217978
92	GATA4_25053715_ChIP-Seq_YYC3_Human	0.99971494
93	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.99561659
94	KLF5_25053715_ChIP-Seq_YYC3_Human	0.98752772
95	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.98275664
96	EWS_26573619_Chip-Seq_HEK293_Human	0.98171019
97	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.97312428
98	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.95979099
99	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.95726425
100	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95667793

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	6.85495275
2	MP0008875_abnormal_xenobiotic_pharmacok	6.24742856
3	MP0002132_abnormal_respiratory_system	4.31914581
4	MP0001984_abnormal_olfaction	4.15854755
5	MP0004133_heterotaxia	3.85996080
6	MP0004043_abnormal_pH_regulation	3.79289732
7	MP0002277_abnormal_respiratory_mucosa	3.47725703
8	MP0000566_synostosis	2.91025976
9	MP0005623_abnormal_meninges_morphology	2.86910633
10	MP0005377_hearing/vestibular/ear_phenot	2.86502921
11	MP0003878_abnormal_ear_physiology	2.86502921
12	MP0008789_abnormal_olfactory_epithelium	2.68490263
13	MP0003136_yellow_coat_color	2.59882141
14	MP0009780_abnormal_chondrocyte_physiolo	2.42128480
15	MP0004019_abnormal_vitamin_homeostasis	2.23528367
16	MP0002160_abnormal_reproductive_system	2.23442909
17	MP0002282_abnormal_trachea_morphology	2.09568735
18	MP0000383_abnormal_hair_follicle	2.00511217
19	MP0005499_abnormal_olfactory_system	1.77901967
20	MP0005394_taste/olfaction_phenotype	1.77901967
21	MP0001485_abnormal_pinna_reflex	1.65511741
22	MP0002876_abnormal_thyroid_physiology	1.61109454
23	MP0009046_muscle_twitch	1.57695850
24	MP0005083_abnormal_biliary_tract	1.57307746
25	MP0001765_abnormal_ion_homeostasis	1.56409509
26	MP0002638_abnormal_pupillary_reflex	1.54729387
27	MP0002734_abnormal_mechanical_nocicepti	1.51160925
28	MP0003806_abnormal_nucleotide_metabolis	1.46895613
29	MP0002909_abnormal_adrenal_gland	1.45973373
30	MP0002168_other_aberrant_phenotype	1.42038807
31	MP0010678_abnormal_skin_adnexa	1.41150409
32	MP0005551_abnormal_eye_electrophysiolog	1.34133206
33	MP0005389_reproductive_system_phenotype	1.29292784
34	MP0005253_abnormal_eye_physiology	1.25475289
35	MP0009379_abnormal_foot_pigmentation	1.21295914
36	MP0003195_calcinosis	1.14608164
37	MP0003656_abnormal_erythrocyte_physiolo	1.12942757
38	MP0001346_abnormal_lacrimal_gland	1.12180003
39	MP0005365_abnormal_bile_salt	1.10549795
40	MP0002928_abnormal_bile_duct	1.06005144
41	MP0005636_abnormal_mineral_homeostasis	1.04722207
42	MP0005408_hypopigmentation	1.04466290
43	MP0000026_abnormal_inner_ear	1.02844221
44	MP0001324_abnormal_eye_pigmentation	1.02823267
45	MP0001502_abnormal_circadian_rhythm	1.02433277
46	MP0003698_abnormal_male_reproductive	1.01028946
47	MP0005085_abnormal_gallbladder_physiolo	1.00735435
48	MP0002735_abnormal_chemical_nociception	1.00641287
49	MP0001929_abnormal_gametogenesis	0.98751542
50	MP0002233_abnormal_nose_morphology	0.94351701
51	MP0004885_abnormal_endolymph	0.93907438
52	MP0005395_other_phenotype	0.93613261
53	MP0009745_abnormal_behavioral_response	0.91857437
54	MP0008872_abnormal_physiological_respon	0.90023034
55	MP0010030_abnormal_orbit_morphology	0.86268214
56	MP0001970_abnormal_pain_threshold	0.86001714
57	MP0001293_anophthalmia	0.84711551
58	MP0005165_increased_susceptibility_to	0.84697721
59	MP0001486_abnormal_startle_reflex	0.80573161
60	MP0006072_abnormal_retinal_apoptosis	0.79449765
61	MP0005195_abnormal_posterior_eye	0.78182014
62	MP0001963_abnormal_hearing_physiology	0.76754924
63	MP0002249_abnormal_larynx_morphology	0.76648231
64	MP0003938_abnormal_ear_development	0.74837394
65	MP0009643_abnormal_urine_homeostasis	0.74587306
66	MP0002136_abnormal_kidney_physiology	0.71778400
67	MP0003937_abnormal_limbs/digits/tail_de	0.71666875
68	MP0005503_abnormal_tendon_morphology	0.70270940
69	MP0002272_abnormal_nervous_system	0.69576523
70	MP0001188_hyperpigmentation	0.68447897
71	MP0002822_catalepsy	0.67914769
72	MP0006036_abnormal_mitochondrial_physio	0.67562568
73	MP0003283_abnormal_digestive_organ	0.67317454
74	MP0003890_abnormal_embryonic-extraembry	0.65077725
75	MP0005220_abnormal_exocrine_pancreas	0.64766310
76	MP0002229_neurodegeneration	0.63331348
77	MP0005391_vision/eye_phenotype	0.63024858
78	MP0002102_abnormal_ear_morphology	0.62497471
79	MP0001944_abnormal_pancreas_morphology	0.62135850
80	MP0002572_abnormal_emotion/affect_behav	0.61158991
81	MP0010155_abnormal_intestine_physiology	0.61148656
82	MP0000678_abnormal_parathyroid_gland	0.59696664
83	MP0005646_abnormal_pituitary_gland	0.59014622
84	MP0005310_abnormal_salivary_gland	0.58941780
85	MP0009765_abnormal_xenobiotic_induced	0.58538990
86	MP0005248_abnormal_Harderian_gland	0.58323771
87	MP0000631_abnormal_neuroendocrine_gland	0.57985761
88	MP0003879_abnormal_hair_cell	0.57920421
89	MP0001663_abnormal_digestive_system	0.56477849
90	MP0000465_gastrointestinal_hemorrhage	0.55705809
91	MP0001905_abnormal_dopamine_level	0.55631429
92	MP0008995_early_reproductive_senescence	0.54729449
93	MP0002557_abnormal_social/conspecific_i	0.54398471
94	MP0001664_abnormal_digestion	0.53753059
95	MP0006276_abnormal_autonomic_nervous	0.53505540
96	MP0000955_abnormal_spinal_cord	0.53410055
97	MP0000049_abnormal_middle_ear	0.51001058
98	MP0002752_abnormal_somatic_nervous	0.49735998
99	MP0002098_abnormal_vibrissa_morphology	0.48413512
100	MP0005164_abnormal_response_to	0.47158052

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rhinitis (HP:0012384)	9.82983612
2	Chronic bronchitis (HP:0004469)	7.52189974
3	Bronchiectasis (HP:0002110)	7.20946166
4	Nasal polyposis (HP:0100582)	6.41652357
5	Abnormality of the nasal mucosa (HP:0000433)	5.29784235
6	Chronic sinusitis (HP:0011109)	4.26682644
7	Bronchitis (HP:0012387)	4.20106770
8	Infertility (HP:0000789)	4.18869085
9	Recurrent sinusitis (HP:0011108)	4.11179494
10	Pancreatic fibrosis (HP:0100732)	4.07396042
11	True hermaphroditism (HP:0010459)	4.05219325
12	Occipital encephalocele (HP:0002085)	4.01158842
13	Abnormality of midbrain morphology (HP:0002418)	3.66977494
14	Molar tooth sign on MRI (HP:0002419)	3.66977494
15	Recurrent otitis media (HP:0000403)	3.59226696
16	Pancreatic cysts (HP:0001737)	3.54714255
17	Nephronophthisis (HP:0000090)	3.42742136
18	Cystic liver disease (HP:0006706)	3.27865795
19	Male infertility (HP:0003251)	3.20031923
20	Chronic hepatic failure (HP:0100626)	2.98405166
21	Chronic otitis media (HP:0000389)	2.95496963
22	Atelectasis (HP:0100750)	2.72404179
23	Abnormality of the renal medulla (HP:0100957)	2.65999211
24	Postaxial foot polydactyly (HP:0001830)	2.57943247
25	Hyperactive renin-angiotensin system (HP:0000841)	2.51551169
26	Medial flaring of the eyebrow (HP:0010747)	2.44141766
27	Congenital hepatic fibrosis (HP:0002612)	2.41410217
28	Tubular atrophy (HP:0000092)	2.35908312
29	Anencephaly (HP:0002323)	2.35555237
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.32467980
31	Tubulointerstitial nephritis (HP:0001970)	2.22988933
32	Male pseudohermaphroditism (HP:0000037)	2.22048387
33	Sclerocornea (HP:0000647)	2.10292877
34	Furrowed tongue (HP:0000221)	2.07771972
35	Gait imbalance (HP:0002141)	2.06464913
36	Congenital primary aphakia (HP:0007707)	2.05063947
37	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.0904651
38	Abnormal respiratory motile cilium physiology (HP:0012261)	10.9907480
39	Abnormal respiratory motile cilium morphology (HP:0005938)	10.9355751
40	Abnormal respiratory epithelium morphology (HP:0012253)	10.9355751
41	Abnormal ciliary motility (HP:0012262)	10.8282939
42	Absent/shortened dynein arms (HP:0200106)	10.6433182
43	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.6433182
44	Recurrent bronchitis (HP:0002837)	1.91799567
45	Asplenia (HP:0001746)	1.90475472
46	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90328463
47	Decreased circulating renin level (HP:0003351)	1.87606630
48	Oculomotor apraxia (HP:0000657)	1.86683910
49	Nephrogenic diabetes insipidus (HP:0009806)	1.80675762
50	Postaxial hand polydactyly (HP:0001162)	1.78288705
51	Bell-shaped thorax (HP:0001591)	1.65841513
52	Nephropathy (HP:0000112)	1.64159021
53	Renal salt wasting (HP:0000127)	1.58023445
54	Abnormal drinking behavior (HP:0030082)	1.55026667
55	Polydipsia (HP:0001959)	1.55026667
56	Preaxial hand polydactyly (HP:0001177)	1.54612116
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.53376342
58	Tubulointerstitial abnormality (HP:0001969)	1.53024789
59	Vaginal atresia (HP:0000148)	1.48722190
60	Genital tract atresia (HP:0001827)	1.47287863
61	Absent frontal sinuses (HP:0002688)	1.47236689
62	Abnormality of the renal cortex (HP:0011035)	1.46956260
63	Decreased central vision (HP:0007663)	1.42354278
64	Poor coordination (HP:0002370)	1.42271783
65	Bile duct proliferation (HP:0001408)	1.40006661
66	Abnormal biliary tract physiology (HP:0012439)	1.40006661
67	Stage 5 chronic kidney disease (HP:0003774)	1.39201392
68	Median cleft lip (HP:0000161)	1.38838126
69	Hyperkalemia (HP:0002153)	1.34958852
70	Abnormality of renin-angiotensin system (HP:0000847)	1.33339899
71	Supernumerary spleens (HP:0009799)	1.32924016
72	Hyperaldosteronism (HP:0000859)	1.32809341
73	Short nail (HP:0001799)	1.28515995
74	Tubulointerstitial fibrosis (HP:0005576)	1.25809557
75	Abnormality of the dental root (HP:0006486)	1.24587381
76	Taurodontia (HP:0000679)	1.24587381
77	Abnormality of permanent molar morphology (HP:0011071)	1.24587381
78	Abnormal rod and cone electroretinograms (HP:0008323)	1.19889809
79	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.18892223
80	Abnormality of chloride homeostasis (HP:0011422)	1.16931980
81	Abnormality of molar (HP:0011077)	1.14584233
82	Abnormality of molar morphology (HP:0011070)	1.14584233
83	Narrow forehead (HP:0000341)	1.14582167
84	Retinitis pigmentosa (HP:0000510)	1.13262324
85	Abdominal situs inversus (HP:0003363)	1.12851998
86	Abnormality of abdominal situs (HP:0011620)	1.12851998
87	Absent speech (HP:0001344)	1.12478632
88	Hypokalemic alkalosis (HP:0001949)	1.12362291
89	Abnormality of the dental pulp (HP:0006479)	1.12020018
90	Abnormality of dentin (HP:0010299)	1.10486861
91	Abnormality of macular pigmentation (HP:0008002)	1.06820684
92	Short thorax (HP:0010306)	1.06708942
93	Aganglionic megacolon (HP:0002251)	1.06452399
94	Prominent nasal bridge (HP:0000426)	1.05765129
95	Polyuria (HP:0000103)	1.04976637
96	Multicystic kidney dysplasia (HP:0000003)	1.03289847
97	Abnormality of the frontal sinuses (HP:0002687)	1.01330924
98	Cone-rod dystrophy (HP:0000548)	1.00880550
99	Optic nerve coloboma (HP:0000588)	1.00269157
100	Nonprogressive disorder (HP:0003680)	0.98137924

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	5.11152795
2	EPHA2	3.46227130
3	MAPKAPK3	2.63338810
4	PTK2B	2.18510446
5	TLK1	2.13285977
6	MAPK15	11.6071744
7	PNCK	1.99681115
8	NME1	1.84747207
9	MAP3K2	1.64915754
10	STK24	1.64901029
11	FRK	1.45234963
12	BCR	1.43256474
13	ADRBK2	1.41646762
14	STK16	1.39523815
15	GRK1	1.26920676
16	PINK1	1.24201937
17	WNK3	1.21548653
18	TTK	1.21331009
19	WNK4	1.18048435
20	MAP3K4	1.14510503
21	CSK	1.10539508
22	CCNB1	1.04776175
23	MAP3K3	1.04175173
24	TRPM7	1.01706606
25	PRKCI	1.01543177
26	MUSK	1.00519478
27	MAP3K12	0.99164685
28	NEK6	0.90753200
29	EEF2K	0.86576541
30	STK38L	0.86563260
31	INSRR	0.84119657
32	BMPR1B	0.80714253
33	MAP2K7	0.76731966
34	MAP3K7	0.76249349
35	CAMKK1	0.75526977
36	LATS1	0.75463742
37	LRRK2	0.74405037
38	CAMKK2	0.74289495
39	STK39	0.73926578
40	STK38	0.70126122
41	PRKCQ	0.69917672
42	TSSK6	0.69731529
43	GRK6	0.69730738
44	ADRBK1	0.68050498
45	MAP4K2	0.67463490
46	BRSK2	0.65181195
47	SMG1	0.64760288
48	ERBB3	0.63185679
49	EPHA3	0.62310898
50	MAPK13	0.59333348
51	ERBB2	0.58909123
52	TXK	0.57833020
53	STK10	0.56348999
54	EPHB1	0.55889821
55	OXSR1	0.55717156
56	MARK2	0.55467060
57	MAP2K4	0.54859210
58	ACVR1B	0.51183451
59	AURKA	0.47170360
60	MAPKAPK5	0.43114833
61	PASK	0.41468273
62	NLK	0.41405685
63	TBK1	0.41012024
64	DYRK3	0.39114044
65	PRKACA	0.38815181
66	PRKCD	0.38601839
67	CAMK2G	0.37844263
68	SGK1	0.36974809
69	WEE1	0.35823232
70	CAMK2A	0.35720091
71	DYRK1A	0.34829290
72	MST1R	0.34216878
73	NEK2	0.33998338
74	PRKCE	0.32307486
75	MAP2K6	0.29527065
76	MAP2K2	0.29276404
77	PRKCA	0.29195454
78	TAOK1	0.29115038
79	ITK	0.28185620
80	TIE1	0.28148204
81	PRKCG	0.27083175
82	CHUK	0.25514823
83	IRAK1	0.24592259
84	TEC	0.23377425
85	CDK8	0.22867363
86	PRKG1	0.22294387
87	PHKG1	0.22058880
88	PHKG2	0.22058880
89	PRKAA2	0.21436178
90	PLK1	0.21060344
91	RPS6KB2	0.20802882
92	CDK19	0.20712366
93	ABL1	0.20266378
94	DYRK2	0.19980814
95	CSNK1G2	0.18631358
96	HIPK2	0.18325315
97	SGK223	0.17704409
98	SGK494	0.17704409
99	AKT2	0.17527061
100	MYLK	0.16811445

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.06471316
2	Chemical carcinogenesis_Homo sapiens_hsa05204	4.24559739
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.04651066
4	Histidine metabolism_Homo sapiens_hsa00340	3.89257645
5	Phenylalanine metabolism_Homo sapiens_hsa00360	3.84243969
6	Huntingtons disease_Homo sapiens_hsa05016	3.35710458
7	Tyrosine metabolism_Homo sapiens_hsa00350	3.05572818
8	beta-Alanine metabolism_Homo sapiens_hsa00410	2.64127946
9	Caffeine metabolism_Homo sapiens_hsa00232	2.51853643
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39544164
11	Glutathione metabolism_Homo sapiens_hsa00480	2.39469299
12	Retinol metabolism_Homo sapiens_hsa00830	2.32163179
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.00097948
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.73655695
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.64470573
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62679691
17	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.62524776
18	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.44915578
19	ABC transporters_Homo sapiens_hsa02010	1.40482940
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.39019802
21	Peroxisome_Homo sapiens_hsa04146	1.35576938
22	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.30025780
23	Nicotine addiction_Homo sapiens_hsa05033	1.23565723
24	Phototransduction_Homo sapiens_hsa04744	1.23270488
25	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.21925426
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.19465114
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.19406672
28	Sphingolipid metabolism_Homo sapiens_hsa00600	1.19294866
29	Fatty acid degradation_Homo sapiens_hsa00071	1.12245758
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.12077873
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.11112925
32	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.09939347
33	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.06606665
34	Salivary secretion_Homo sapiens_hsa04970	1.05663015
35	Tight junction_Homo sapiens_hsa04530	1.05608017
36	Olfactory transduction_Homo sapiens_hsa04740	1.01637126
37	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.00462364
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.99213440
39	Butanoate metabolism_Homo sapiens_hsa00650	0.98133896
40	Taste transduction_Homo sapiens_hsa04742	0.96446400
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.87572525
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86974094
43	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84427606
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81618915
45	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.78531744
46	Tryptophan metabolism_Homo sapiens_hsa00380	0.74465458
47	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.74319460
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.74122504
49	Circadian rhythm_Homo sapiens_hsa04710	0.73990140
50	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.71670745
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70996867
52	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.68355147
53	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68158785
54	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.68032425
55	Alzheimers disease_Homo sapiens_hsa05010	0.64727407
56	Parkinsons disease_Homo sapiens_hsa05012	0.64091185
57	Serotonergic synapse_Homo sapiens_hsa04726	0.62796284
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.61596348
59	Metabolic pathways_Homo sapiens_hsa01100	0.58190336
60	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.56223707
61	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.56026519
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44655754
63	Asthma_Homo sapiens_hsa05310	0.43485643
64	Ether lipid metabolism_Homo sapiens_hsa00565	0.42297819
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.41955797
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.39757561
67	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39009814
68	Arginine and proline metabolism_Homo sapiens_hsa00330	0.38773873
69	Regulation of autophagy_Homo sapiens_hsa04140	0.38743610
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38264097
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.37899553
72	PPAR signaling pathway_Homo sapiens_hsa03320	0.34677079
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.34655733
74	Allograft rejection_Homo sapiens_hsa05330	0.34638985
75	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.33037841
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31031847
77	Cocaine addiction_Homo sapiens_hsa05030	0.30120773
78	Graft-versus-host disease_Homo sapiens_hsa05332	0.30089568
79	Nucleotide excision repair_Homo sapiens_hsa03420	0.29994027
80	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.29528804
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.29486001
82	Protein export_Homo sapiens_hsa03060	0.28483880
83	Hippo signaling pathway_Homo sapiens_hsa04390	0.28122301
84	Purine metabolism_Homo sapiens_hsa00230	0.28061133
85	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27847808
86	Notch signaling pathway_Homo sapiens_hsa04330	0.27186529
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.25979596
88	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.25605280
89	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.25572195
90	Propanoate metabolism_Homo sapiens_hsa00640	0.25128386
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.24262981
92	Mineral absorption_Homo sapiens_hsa04978	0.21786347
93	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.21641943
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.17009188
95	Pancreatic secretion_Homo sapiens_hsa04972	0.15920908
96	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.15246181
97	Amphetamine addiction_Homo sapiens_hsa05031	0.14737587
98	Choline metabolism in cancer_Homo sapiens_hsa05231	0.13901564
99	Complement and coagulation cascades_Homo sapiens_hsa04610	0.13645085
100	Basal transcription factors_Homo sapiens_hsa03022	0.13083593

C11ORF88

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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