ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to ATP (GO:0071318)	9.59386554
2	negative regulation of cell aging (GO:0090344)	8.70239668
3	DNA strand renaturation (GO:0000733)	8.46167550
4	adenosine receptor signaling pathway (GO:0001973)	8.21813428
5	GDP-mannose metabolic process (GO:0019673)	8.19999612
6	regulation of skeletal muscle contraction (GO:0014819)	7.87770047
7	meiotic chromosome segregation (GO:0045132)	7.27619293
8	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	7.12866001
9	peptidyl-glutamic acid carboxylation (GO:0017187)	6.88304698
10	protein carboxylation (GO:0018214)	6.88304698
11	rRNA methylation (GO:0031167)	6.63512856
12	purinergic nucleotide receptor signaling pathway (GO:0035590)	6.62714908
13	regulation of synapse structural plasticity (GO:0051823)	6.59788961
14	sensory perception of taste (GO:0050909)	6.48413100
15	lens fiber cell differentiation (GO:0070306)	6.43703936
16	mitotic cell cycle arrest (GO:0071850)	6.30557910
17	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	5.86551372
18	rRNA modification (GO:0000154)	5.70588178
19	regulation of cytokine production involved in inflammatory response (GO:1900015)	5.32878608
20	response to ATP (GO:0033198)	5.23551020
21	positive regulation of protein kinase C signaling (GO:0090037)	5.22161958
22	adenine nucleotide transport (GO:0051503)	5.04303646
23	purine ribonucleotide transport (GO:0015868)	5.01968275
24	purinergic receptor signaling pathway (GO:0035587)	4.96412632
25	urinary tract smooth muscle contraction (GO:0014848)	4.90093819
26	behavioral response to nicotine (GO:0035095)	4.84004541
27	estrogen biosynthetic process (GO:0006703)	4.75892654
28	regulation of protein kinase A signaling (GO:0010738)	4.50024858
29	detection of light stimulus involved in visual perception (GO:0050908)	4.46461783
30	detection of light stimulus involved in sensory perception (GO:0050962)	4.46461783
31	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	4.44605928
32	UV protection (GO:0009650)	4.43804001
33	transepithelial transport (GO:0070633)	4.38981634
34	positive regulation of megakaryocyte differentiation (GO:0045654)	4.37492744
35	positive regulation of heat generation (GO:0031652)	4.27140528
36	peristalsis (GO:0030432)	4.19182577
37	nucleoside transmembrane transport (GO:1901642)	4.18055531
38	melanin biosynthetic process (GO:0042438)	4.14483436
39	regulation of cell aging (GO:0090342)	4.09613849
40	neuromuscular synaptic transmission (GO:0007274)	3.98794039
41	mannose metabolic process (GO:0006013)	3.92639901
42	melanin metabolic process (GO:0006582)	3.89037270
43	purine nucleotide transport (GO:0015865)	3.88865961
44	protein import into peroxisome matrix (GO:0016558)	3.88020310
45	granulocyte differentiation (GO:0030851)	3.87401283
46	nucleotide transmembrane transport (GO:1901679)	3.86765315
47	semaphorin-plexin signaling pathway (GO:0071526)	3.81860402
48	protein retention in ER lumen (GO:0006621)	3.76348131
49	protein insertion into membrane (GO:0051205)	3.74856508
50	nucleotide-sugar biosynthetic process (GO:0009226)	3.72398435
51	positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)	3.71363551
52	sex determination (GO:0007530)	3.65611453
53	mitochondrion distribution (GO:0048311)	3.58166124
54	regulation of phospholipid biosynthetic process (GO:0071071)	3.57652120
55	negative regulation of interleukin-8 production (GO:0032717)	3.56686576
56	cell migration in hindbrain (GO:0021535)	3.56410951
57	histone phosphorylation (GO:0016572)	3.54157929
58	sialylation (GO:0097503)	3.46382053
59	endocytic recycling (GO:0032456)	3.45021749
60	sphingosine metabolic process (GO:0006670)	3.39861231
61	grooming behavior (GO:0007625)	3.35592164
62	type B pancreatic cell proliferation (GO:0044342)	3.35175934
63	sphingomyelin metabolic process (GO:0006684)	3.34672755
64	interferon-gamma production (GO:0032609)	3.31822557
65	phosphatidylglycerol biosynthetic process (GO:0006655)	3.31145750
66	activation of adenylate cyclase activity (GO:0007190)	3.30529174
67	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.28638679
68	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.28638679
69	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.28638679
70	peptidyl-glutamic acid modification (GO:0018200)	3.28551846
71	gonadal mesoderm development (GO:0007506)	3.27014497
72	DNA replication checkpoint (GO:0000076)	3.22472174
73	sulfur amino acid catabolic process (GO:0000098)	3.22127694
74	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.19118929
75	iron coordination entity transport (GO:1901678)	3.16138277
76	folic acid metabolic process (GO:0046655)	3.16095828
77	tRNA modification (GO:0006400)	3.15038202
78	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.13265230
79	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	3.09432334
80	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.09100310
81	secondary metabolite biosynthetic process (GO:0044550)	3.08332795
82	diol metabolic process (GO:0034311)	3.08180291
83	cellular anion homeostasis (GO:0030002)	3.02687222
84	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.02526805
85	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.02312278
86	cardiolipin metabolic process (GO:0032048)	3.01629688
87	cilium or flagellum-dependent cell motility (GO:0001539)	3.01052517
88	regulation of heat generation (GO:0031650)	3.00741735
89	snRNA transcription (GO:0009301)	3.00636425
90	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.90647119
91	trivalent inorganic anion homeostasis (GO:0072506)	2.89714745
92	phosphate ion homeostasis (GO:0055062)	2.89714745
93	nucleoside transport (GO:0015858)	2.88139412
94	microtubule depolymerization (GO:0007019)	2.85823326
95	phosphate ion transmembrane transport (GO:0035435)	2.85488763
96	positive regulation of adenylate cyclase activity (GO:0045762)	2.85400646
97	tachykinin receptor signaling pathway (GO:0007217)	2.85389514
98	ribosomal small subunit biogenesis (GO:0042274)	2.84576016
99	DNA duplex unwinding (GO:0032508)	2.84390063
100	positive regulation of blood pressure (GO:0045777)	2.84332780

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	4.38900085
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.13537028
3	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.16099108
4	LXR_22292898_ChIP-Seq_THP-1_Human	3.13457982
5	P68_20966046_ChIP-Seq_HELA_Human	3.06105651
6	XRN2_22483619_ChIP-Seq_HELA_Human	2.63018495
7	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.54933770
8	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.53510632
9	MAF_26560356_Chip-Seq_TH2_Human	2.47875991
10	E2F1_20622854_ChIP-Seq_HELA_Human	2.37629525
11	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.35689797
12	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.34254501
13	BCOR_27268052_Chip-Seq_Bcells_Human	2.29133760
14	* CTCF_27219007_Chip-Seq_Bcells_Human	2.28804490
15	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.23195377
16	PHF8_20622854_ChIP-Seq_HELA_Human	2.22215167
17	BCL6_27268052_Chip-Seq_Bcells_Human	2.20212192
18	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.20073199
19	RACK7_27058665_Chip-Seq_MCF-7_Human	2.14999193
20	VDR_24763502_ChIP-Seq_THP-1_Human	2.13316302
21	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.12896000
22	CTCF_27219007_Chip-Seq_ERYTHROID_Human	2.10936204
23	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.97911760
24	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.95618746
25	MYC_22102868_ChIP-Seq_BL_Human	1.94349848
26	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.94165892
27	* MAF_26560356_Chip-Seq_TH1_Human	1.89707999
28	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.88163008
29	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.84021155
30	CTCF_21964334_Chip-Seq_Bcells_Human	1.83926075
31	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.83636834
32	TP53_22127205_ChIP-Seq_IMR90_Human	1.82032990
33	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.81929268
34	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.81273568
35	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.81089911
36	* SMC4_20622854_ChIP-Seq_HELA_Human	1.80873552
37	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.80568581
38	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.74505396
39	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.71236609
40	KDM2B_26808549_Chip-Seq_DND41_Human	1.66959519
41	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.65963525
42	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.64273313
43	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.62242909
44	CREB1_26743006_Chip-Seq_LNCaP_Human	1.60991879
45	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.59122673
46	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.58692305
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.51860094
48	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.51833520
49	UTX_26944678_Chip-Seq_JUKART_Human	1.51570278
50	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50223273
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.49112286
52	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.48234561
53	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.48099576
54	TCF7_22412390_ChIP-Seq_EML_Mouse	1.47992713
55	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.45824743
56	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.45710555
57	CTCF_20526341_ChIP-Seq_ESCs_Human	1.43942241
58	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.42948145
59	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.42187390
60	CIITA_25753668_ChIP-Seq_RAJI_Human	1.40368669
61	ERA_21632823_ChIP-Seq_H3396_Human	1.35132016
62	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.35035697
63	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.34219440
64	SA1_27219007_Chip-Seq_Bcells_Human	1.34020937
65	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.33325357
66	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.32883924
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.30463351
68	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.26926096
69	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.24446987
70	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.23590744
71	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.20481304
72	KDM2B_26808549_Chip-Seq_K562_Human	1.20283427
73	NCOR1_26117541_ChIP-Seq_K562_Human	1.20224829
74	ATF3_27146783_Chip-Seq_COLON_Human	1.19790824
75	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.17884451
76	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.17787811
77	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.15811866
78	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.14861554
79	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.14121350
80	* UBF1/2_26484160_Chip-Seq_HMECs_Human	1.11961839
81	P300_27268052_Chip-Seq_Bcells_Human	1.11455739
82	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.10897164
83	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.10682911
84	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.09320158
85	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.08645081
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.06060253
87	OCT4_19829295_ChIP-Seq_ESCs_Human	1.05414890
88	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.04902227
89	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.04634834
90	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.04469713
91	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.03736109
92	GABP_19822575_ChIP-Seq_HepG2_Human	1.03629209
93	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.03469312
94	DCP1A_22483619_ChIP-Seq_HELA_Human	1.02962844
95	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.02470857
96	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.01005616
97	* TP63_22573176_ChIP-Seq_HFKS_Human	1.00579708
98	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.99620166
99	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.97765128
100	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.97587360

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	7.14770191
2	MP0005174_abnormal_tail_pigmentation	6.73976875
3	MP0001986_abnormal_taste_sensitivity	6.20272982
4	MP0005423_abnormal_somatic_nervous	5.88074118
5	MP0003136_yellow_coat_color	4.77126149
6	MP0001188_hyperpigmentation	3.79391893
7	MP0005409_darkened_coat_color	3.51121395
8	MP0005083_abnormal_biliary_tract	3.20096663
9	MP0001968_abnormal_touch/_nociception	2.89586346
10	MP0000015_abnormal_ear_pigmentation	2.60188744
11	MP0000751_myopathy	2.40499421
12	MP0001756_abnormal_urination	2.28332033
13	MP0001502_abnormal_circadian_rhythm	2.17068724
14	MP0003705_abnormal_hypodermis_morpholog	2.05988754
15	MP0008875_abnormal_xenobiotic_pharmacok	2.04522067
16	MP0001661_extended_life_span	2.02047197
17	MP0003453_abnormal_keratinocyte_physiol	1.96262696
18	MP0002638_abnormal_pupillary_reflex	1.95019822
19	MP0002160_abnormal_reproductive_system	1.88125142
20	MP0002736_abnormal_nociception_after	1.87317737
21	MP0005410_abnormal_fertilization	1.84818562
22	MP0004381_abnormal_hair_follicle	1.83975142
23	MP0003111_abnormal_nucleus_morphology	1.67403325
24	MP0000538_abnormal_urinary_bladder	1.53635595
25	MP0000750_abnormal_muscle_regeneration	1.52623216
26	MP0004130_abnormal_muscle_cell	1.46859673
27	MP0002735_abnormal_chemical_nociception	1.44939899
28	MP0005058_abnormal_lysosome_morphology	1.36543825
29	MP0005501_abnormal_skin_physiology	1.36320006
30	MP0000747_muscle_weakness	1.28369528
31	MP0003693_abnormal_embryo_hatching	1.24089773
32	MP0005330_cardiomyopathy	1.22920180
33	MP0000013_abnormal_adipose_tissue	1.16390144
34	MP0005332_abnormal_amino_acid	1.11945892
35	MP0009053_abnormal_anal_canal	1.08629844
36	MP0000003_abnormal_adipose_tissue	1.08285292
37	MP0003879_abnormal_hair_cell	1.06519011
38	MP0005377_hearing/vestibular/ear_phenot	0.96803708
39	MP0003878_abnormal_ear_physiology	0.96803708
40	MP0005365_abnormal_bile_salt	0.96551103
41	MP0003077_abnormal_cell_cycle	0.95172864
42	MP0000470_abnormal_stomach_morphology	0.94033877
43	MP0005076_abnormal_cell_differentiation	0.93361680
44	MP0005551_abnormal_eye_electrophysiolog	0.91512632
45	MP0001765_abnormal_ion_homeostasis	0.88263653
46	MP0005584_abnormal_enzyme/coenzyme_acti	0.87978082
47	MP0009840_abnormal_foam_cell	0.86102541
48	MP0004957_abnormal_blastocyst_morpholog	0.84363358
49	MP0003806_abnormal_nucleotide_metabolis	0.84191163
50	MP0005367_renal/urinary_system_phenotyp	0.83383573
51	MP0000516_abnormal_urinary_system	0.83383573
52	MP0001919_abnormal_reproductive_system	0.82095039
53	MP0010094_abnormal_chromosome_stability	0.81336465
54	MP0002909_abnormal_adrenal_gland	0.79529840
55	MP0001348_abnormal_lacrimal_gland	0.78229987
56	MP0001664_abnormal_digestion	0.78078362
57	MP0005257_abnormal_intraocular_pressure	0.75467238
58	MP0000367_abnormal_coat/_hair	0.74401504
59	MP0001970_abnormal_pain_threshold	0.73479978
60	MP0004043_abnormal_pH_regulation	0.72969588
61	MP0005220_abnormal_exocrine_pancreas	0.72168556
62	MP0002928_abnormal_bile_duct	0.71499452
63	MP0010771_integument_phenotype	0.71250084
64	MP0009278_abnormal_bone_marrow	0.70374828
65	MP0009931_abnormal_skin_appearance	0.69929382
66	MP0005389_reproductive_system_phenotype	0.68478673
67	MP0003091_abnormal_cell_migration	0.68437430
68	MP0003448_altered_tumor_morphology	0.68123197
69	MP0001958_emphysema	0.67818509
70	MP0000778_abnormal_nervous_system	0.65875718
71	MP0005623_abnormal_meninges_morphology	0.63242686
72	MP0005084_abnormal_gallbladder_morpholo	0.62841607
73	MP0001905_abnormal_dopamine_level	0.60846979
74	MP0009379_abnormal_foot_pigmentation	0.60690757
75	MP0000358_abnormal_cell_content/	0.59937294
76	MP0004019_abnormal_vitamin_homeostasis	0.58522818
77	MP0002019_abnormal_tumor_incidence	0.58376374
78	MP0010386_abnormal_urinary_bladder	0.57925752
79	MP0009643_abnormal_urine_homeostasis	0.57343074
80	MP0003303_peritoneal_inflammation	0.56944004
81	MP0005253_abnormal_eye_physiology	0.55219639
82	MP0004185_abnormal_adipocyte_glucose	0.53670819
83	MP0003315_abnormal_perineum_morphology	0.51608026
84	MP0003137_abnormal_impulse_conducting	0.50649989
85	MP0003172_abnormal_lysosome_physiology	0.50324004
86	MP0001324_abnormal_eye_pigmentation	0.50143030
87	MP0002254_reproductive_system_inflammat	0.49939400
88	MP0003698_abnormal_male_reproductive	0.48141719
89	MP0002210_abnormal_sex_determination	0.47863859
90	MP0004197_abnormal_fetal_growth/weight/	0.47100870
91	MP0008874_decreased_physiological_sensi	0.46965030
92	MP0002136_abnormal_kidney_physiology	0.45784581
93	MP0002075_abnormal_coat/hair_pigmentati	0.45646355
94	MP0008770_decreased_survivor_rate	0.43898185
95	MP0001873_stomach_inflammation	0.39952717
96	MP0005375_adipose_tissue_phenotype	0.39686101
97	MP0001191_abnormal_skin_condition	0.38778158
98	MP0004087_abnormal_muscle_fiber	0.38071988
99	MP0002095_abnormal_skin_pigmentation	0.37465572
100	MP0003385_abnormal_body_wall	0.34624006

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rib fusion (HP:0000902)	6.50097164
2	Testicular atrophy (HP:0000029)	6.17652900
3	Rectal fistula (HP:0100590)	5.74677424
4	Rectovaginal fistula (HP:0000143)	5.74677424
5	Thin bony cortex (HP:0002753)	5.72960880
6	Intestinal fistula (HP:0100819)	5.38499923
7	Poikiloderma (HP:0001029)	5.25113782
8	Vaginal fistula (HP:0004320)	5.25021638
9	Attenuation of retinal blood vessels (HP:0007843)	5.07712131
10	Dyschromatopsia (HP:0007641)	4.96191126
11	Facial hemangioma (HP:0000329)	4.90736916
12	Annular pancreas (HP:0001734)	4.70867954
13	Ulnar bowing (HP:0003031)	4.62116392
14	Abnormality of the intrinsic pathway (HP:0010989)	4.38056720
15	Popliteal pterygium (HP:0009756)	4.31704882
16	Turricephaly (HP:0000262)	4.22300688
17	Hemorrhage of the eye (HP:0011885)	4.09707812
18	Fetal akinesia sequence (HP:0001989)	4.05318074
19	Bony spicule pigmentary retinopathy (HP:0007737)	4.03423121
20	Mesangial abnormality (HP:0001966)	4.01189858
21	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	4.00418609
22	Delayed epiphyseal ossification (HP:0002663)	3.94355638
23	Coronal craniosynostosis (HP:0004440)	3.88286635
24	Facial diplegia (HP:0001349)	3.88249673
25	Akinesia (HP:0002304)	3.85544337
26	Congenital stationary night blindness (HP:0007642)	3.81996035
27	Joint hemorrhage (HP:0005261)	3.78939043
28	Squamous cell carcinoma (HP:0002860)	3.78001976
29	Aplasia of the musculature (HP:0100854)	3.66513937
30	Prolonged partial thromboplastin time (HP:0003645)	3.64964322
31	Chorioretinal atrophy (HP:0000533)	3.61651793
32	Anteriorly placed anus (HP:0001545)	3.59348362
33	Enlarged epiphyses (HP:0010580)	3.58330751
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.37416622
35	Short chin (HP:0000331)	3.34510248
36	Patellar aplasia (HP:0006443)	3.28372866
37	Hypophosphatemic rickets (HP:0004912)	3.20824277
38	Choroideremia (HP:0001139)	3.17612013
39	Abnormality of placental membranes (HP:0011409)	3.10862369
40	Amniotic constriction ring (HP:0009775)	3.10862369
41	Renal Fanconi syndrome (HP:0001994)	3.09273352
42	Capillary hemangiomas (HP:0005306)	3.08296225
43	Abnormality of the costochondral junction (HP:0000919)	3.03096205
44	Aplasia/Hypoplasia of the patella (HP:0006498)	3.02828799
45	Atrioventricular block (HP:0001678)	3.02200163
46	Increased hepatocellular lipid droplets (HP:0006565)	2.98306856
47	Lipid accumulation in hepatocytes (HP:0006561)	2.89875966
48	Absent thumb (HP:0009777)	2.77940853
49	Abnormal albumin level (HP:0012116)	2.72827576
50	Hypoalbuminemia (HP:0003073)	2.72827576
51	Bowing of the arm (HP:0006488)	2.70528862
52	Bowed forearm bones (HP:0003956)	2.70528862
53	Flat occiput (HP:0005469)	2.63686611
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.62380524
55	Joint stiffness (HP:0001387)	2.60952328
56	Widely patent fontanelles and sutures (HP:0004492)	2.55348521
57	Myotonia (HP:0002486)	2.54368535
58	Premature graying of hair (HP:0002216)	2.44433514
59	Male infertility (HP:0003251)	2.41988711
60	Zonular cataract (HP:0010920)	2.40520351
61	Birth length less than 3rd percentile (HP:0003561)	2.39605894
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.39404662
63	Neonatal onset (HP:0003623)	2.37415211
64	Decreased central vision (HP:0007663)	2.37234300
65	Abnormal epiphyseal ossification (HP:0010656)	2.35795918
66	Abnormality of the common coagulation pathway (HP:0010990)	2.29073563
67	Choanal stenosis (HP:0000452)	2.27425928
68	Basal cell carcinoma (HP:0002671)	2.27392876
69	Increased number of teeth (HP:0011069)	2.22561444
70	Narrow nasal bridge (HP:0000446)	2.20839388
71	Pendular nystagmus (HP:0012043)	2.19754445
72	Increased intramyocellular lipid droplets (HP:0012240)	2.18181292
73	Neonatal respiratory distress (HP:0002643)	2.16911987
74	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.15431602
75	Increased muscle lipid content (HP:0009058)	2.15076522
76	Short humerus (HP:0005792)	2.15046355
77	Thin ribs (HP:0000883)	2.10195616
78	Myopathic facies (HP:0002058)	2.09798255
79	Cystic hygroma (HP:0000476)	2.08606293
80	Hypoplasia of the radius (HP:0002984)	2.07473009
81	Abnormality of the hepatic vasculature (HP:0006707)	2.05840682
82	Spina bifida occulta (HP:0003298)	2.05009897
83	Abnormal urine phosphate concentration (HP:0012599)	2.03626691
84	Thrombocytosis (HP:0001894)	2.03201030
85	Breast hypoplasia (HP:0003187)	2.01332803
86	Malignant hyperthermia (HP:0002047)	1.97590985
87	Aplasia/hypoplasia of the humerus (HP:0006507)	1.97379402
88	Short thumb (HP:0009778)	1.93443518
89	Pterygium (HP:0001059)	1.92031469
90	Epiphyseal stippling (HP:0010655)	1.90998468
91	Fatigable weakness (HP:0003473)	1.90607735
92	Abnormality of the neuromuscular junction (HP:0003398)	1.90607735
93	Spontaneous abortion (HP:0005268)	1.87534507
94	Vertebral clefting (HP:0008428)	1.85760892
95	Abnormal trabecular bone morphology (HP:0100671)	1.83277930
96	Muscle fiber atrophy (HP:0100295)	1.83107896
97	Type 2 muscle fiber atrophy (HP:0003554)	1.78730297
98	Absent radius (HP:0003974)	1.78383439
99	Cheilitis (HP:0100825)	1.76465685
100	Exertional dyspnea (HP:0002875)	1.74528823

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	9.38124755
2	WNK4	4.15048203
3	BLK	3.55872949
4	PIM2	3.15416811
5	IRAK2	3.10269434
6	MUSK	2.93099803
7	TRIB3	2.68635788
8	TLK1	2.63845448
9	TESK2	2.40149740
10	DYRK1B	1.94530686
11	SIK2	1.75873954
12	SIK1	1.72292384
13	GRK6	1.69544466
14	ERN1	1.56219632
15	EPHB2	1.51010434
16	PDPK1	1.49290355
17	ZAK	1.48083214
18	STK16	1.44211230
19	PRKD2	1.40815986
20	RPS6KA2	1.37938967
21	CDK6	1.34328283
22	WNK1	1.31415328
23	MAP2K3	1.24598000
24	BRAF	1.22308619
25	CDK4	1.20165093
26	ZAP70	1.17628312
27	IRAK3	1.05796737
28	ICK	1.03652961
29	ADRBK1	0.97532775
30	AKT3	0.95569298
31	EEF2K	0.93346044
32	RPS6KC1	0.90610312
33	RPS6KL1	0.90610312
34	MTOR	0.90523094
35	ARAF	0.89809589
36	BMX	0.89371410
37	CDK15	0.89162907
38	RPS6KA6	0.88249748
39	CDK11A	0.87145483
40	ADRBK2	0.85861493
41	CSK	0.81841016
42	PRKD3	0.81502855
43	CDK18	0.81496565
44	TAOK1	0.81070755
45	CCNB1	0.79194608
46	NEK2	0.77215624
47	AURKA	0.76133548
48	MINK1	0.75674783
49	CDK14	0.75017896
50	PRKD1	0.68952539
51	MST1R	0.66062705
52	MAPK11	0.65022444
53	MAPK8	0.62574193
54	STK11	0.61106861
55	CHEK2	0.56267465
56	CAMK1D	0.56038775
57	SGK223	0.55196368
58	SGK494	0.55196368
59	DYRK3	0.54662924
60	PRKCH	0.53829069
61	TYRO3	0.53484209
62	CSNK1D	0.53408844
63	DAPK3	0.53049874
64	DDR2	0.52947698
65	PAK1	0.51855648
66	CAMK1G	0.51778125
67	MAP2K4	0.50991669
68	MARK2	0.50546369
69	TBK1	0.48205107
70	MAP2K6	0.48049288
71	ACVR1B	0.47054973
72	RPS6KA5	0.43754052
73	CDK12	0.43298305
74	MAP2K7	0.41015346
75	ATR	0.39979166
76	MAP2K2	0.39958944
77	IKBKB	0.38421749
78	EPHA2	0.37679698
79	AKT2	0.35540703
80	MAPK12	0.34055598
81	TRIM28	0.33468699
82	PKN2	0.33264833
83	PDK1	0.33091452
84	MAP3K10	0.29324073
85	CDK1	0.28174697
86	CDK2	0.26820763
87	GSK3B	0.25617036
88	HIPK2	0.24637718
89	PIM1	0.23905512
90	RIPK1	0.23563559
91	RPS6KA1	0.22845021
92	MAPK14	0.22830168
93	ERBB2	0.22807559
94	RAF1	0.22737328
95	CAMK1	0.22095118
96	PDGFRB	0.21675218
97	AKT1	0.20761415
98	TIE1	0.20603440
99	PRKAA1	0.20201315
100	NTRK3	0.19041638

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	7.80391394
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	6.14393238
3	Sulfur relay system_Homo sapiens_hsa04122	5.75800543
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.44287021
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.23715424
6	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.76135861
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.44389959
8	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	2.35273529
9	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.33270012
10	Sphingolipid metabolism_Homo sapiens_hsa00600	1.93642647
11	Circadian rhythm_Homo sapiens_hsa04710	1.62139566
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62116634
13	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.52099461
14	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.47310907
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.38949982
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35642350
17	Taste transduction_Homo sapiens_hsa04742	1.30652015
18	Bladder cancer_Homo sapiens_hsa05219	1.25659330
19	mTOR signaling pathway_Homo sapiens_hsa04150	1.23627629
20	Other glycan degradation_Homo sapiens_hsa00511	1.14825638
21	Nicotine addiction_Homo sapiens_hsa05033	1.14808302
22	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.08052865
23	Alcoholism_Homo sapiens_hsa05034	1.04700700
24	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.94997056
25	VEGF signaling pathway_Homo sapiens_hsa04370	0.93257333
26	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.90196655
27	Lysine degradation_Homo sapiens_hsa00310	0.85805551
28	Lysosome_Homo sapiens_hsa04142	0.83893844
29	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.83241242
30	Base excision repair_Homo sapiens_hsa03410	0.82134138
31	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78223600
32	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.74249061
33	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.70608215
34	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69918763
35	Notch signaling pathway_Homo sapiens_hsa04330	0.69036445
36	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.63269444
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.60315435
38	Axon guidance_Homo sapiens_hsa04360	0.59663549
39	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59211963
40	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.58583610
41	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.56885912
42	Hippo signaling pathway_Homo sapiens_hsa04390	0.55883634
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.54299163
44	Melanogenesis_Homo sapiens_hsa04916	0.53596876
45	Non-small cell lung cancer_Homo sapiens_hsa05223	0.52955217
46	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.52666271
47	Cocaine addiction_Homo sapiens_hsa05030	0.51715337
48	Calcium signaling pathway_Homo sapiens_hsa04020	0.51119919
49	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.50732632
50	Endocytosis_Homo sapiens_hsa04144	0.50597520
51	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.49009259
52	Renin-angiotensin system_Homo sapiens_hsa04614	0.47219360
53	Cell cycle_Homo sapiens_hsa04110	0.45144429
54	Basal transcription factors_Homo sapiens_hsa03022	0.44923202
55	Insulin resistance_Homo sapiens_hsa04931	0.44734809
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43839480
57	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.42396994
58	Gap junction_Homo sapiens_hsa04540	0.40980062
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39574436
60	Acute myeloid leukemia_Homo sapiens_hsa05221	0.39282039
61	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.33288718
62	ErbB signaling pathway_Homo sapiens_hsa04012	0.32253323
63	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.32105759
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.30575136
65	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.30385795
66	Hepatitis C_Homo sapiens_hsa05160	0.29724524
67	Viral carcinogenesis_Homo sapiens_hsa05203	0.28853015
68	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.27519686
69	Insulin signaling pathway_Homo sapiens_hsa04910	0.27498843
70	MAPK signaling pathway_Homo sapiens_hsa04010	0.25798033
71	Glioma_Homo sapiens_hsa05214	0.24008571
72	Endometrial cancer_Homo sapiens_hsa05213	0.23860314
73	Apoptosis_Homo sapiens_hsa04210	0.23786046
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.22963326
75	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.22500930
76	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.21726915
77	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.21658370
78	Cholinergic synapse_Homo sapiens_hsa04725	0.21546387
79	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.20948746
80	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.20659863
81	Pyrimidine metabolism_Homo sapiens_hsa00240	0.19454250
82	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.19284244
83	p53 signaling pathway_Homo sapiens_hsa04115	0.18415699
84	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.17587438
85	Hepatitis B_Homo sapiens_hsa05161	0.17295778
86	Pancreatic cancer_Homo sapiens_hsa05212	0.15567913
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.15183717
88	Melanoma_Homo sapiens_hsa05218	0.14954597
89	Arginine biosynthesis_Homo sapiens_hsa00220	0.14298676
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.13324036
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.13106215
92	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.13007902
93	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.11964760
94	FoxO signaling pathway_Homo sapiens_hsa04068	0.11551925
95	Morphine addiction_Homo sapiens_hsa05032	0.11524419
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.10964050
97	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.10207635
98	cAMP signaling pathway_Homo sapiens_hsa04024	0.09599615
99	Metabolic pathways_Homo sapiens_hsa01100	0.09421875
100	Prostate cancer_Homo sapiens_hsa05215	0.08941015

C11ORF94

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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