ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	4.36661067
2	cell migration in hindbrain (GO:0021535)	4.15926111
3	axonal fasciculation (GO:0007413)	3.96584908
4	axon extension (GO:0048675)	3.95173296
5	neuron recognition (GO:0008038)	3.91799595
6	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.82615768
7	axon extension involved in axon guidance (GO:0048846)	3.82615768
8	postsynaptic membrane organization (GO:0001941)	3.74377161
9	presynaptic membrane organization (GO:0097090)	3.62446518
10	paraxial mesoderm development (GO:0048339)	3.57134969
11	presynaptic membrane assembly (GO:0097105)	3.48362278
12	dendritic spine morphogenesis (GO:0060997)	3.35243032
13	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.34777588
14	neuron projection extension (GO:1990138)	3.32792932
15	negative regulation of catenin import into nucleus (GO:0035414)	3.29378377
16	camera-type eye morphogenesis (GO:0048593)	3.25225824
17	nucleobase catabolic process (GO:0046113)	3.18045589
18	cranial nerve morphogenesis (GO:0021602)	3.17947208
19	ganglion development (GO:0061548)	3.17455688
20	central nervous system projection neuron axonogenesis (GO:0021952)	3.11038995
21	cerebral cortex radially oriented cell migration (GO:0021799)	3.10282063
22	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.01506717
23	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.01276955
24	establishment of mitochondrion localization (GO:0051654)	2.99787491
25	layer formation in cerebral cortex (GO:0021819)	2.99278211
26	convergent extension (GO:0060026)	2.98685645
27	spinal cord development (GO:0021510)	2.93798269
28	mitochondrion transport along microtubule (GO:0047497)	2.90094264
29	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.90094264
30	neuronal ion channel clustering (GO:0045161)	2.82999301
31	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.80821671
32	substrate-independent telencephalic tangential migration (GO:0021826)	2.80821671
33	cell proliferation in forebrain (GO:0021846)	2.78750119
34	neuron cell-cell adhesion (GO:0007158)	2.78212553
35	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.77197821
36	establishment of monopolar cell polarity (GO:0061162)	2.77197821
37	retinal ganglion cell axon guidance (GO:0031290)	2.74595618
38	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.74188090
39	positive regulation of synapse assembly (GO:0051965)	2.73555037
40	regulation of axon extension involved in axon guidance (GO:0048841)	2.71916789
41	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.70999960
42	protein localization to synapse (GO:0035418)	2.70145729
43	regulation of axon guidance (GO:1902667)	2.68203363
44	heterochromatin organization (GO:0070828)	2.66373910
45	developmental cell growth (GO:0048588)	2.65221473
46	outer ear morphogenesis (GO:0042473)	2.64471085
47	lateral sprouting from an epithelium (GO:0060601)	2.63277368
48	dendrite morphogenesis (GO:0048813)	2.62474755
49	head development (GO:0060322)	2.61557483
50	olfactory bulb development (GO:0021772)	2.57333108
51	establishment of nucleus localization (GO:0040023)	2.56193701
52	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.56067263
53	locomotory exploration behavior (GO:0035641)	2.54469932
54	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.53376364
55	negative regulation of axon guidance (GO:1902668)	2.53210064
56	exploration behavior (GO:0035640)	2.53120783
57	renal system development (GO:0072001)	2.52579462
58	dendrite development (GO:0016358)	2.52054216
59	body morphogenesis (GO:0010171)	2.50776011
60	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.49912141
61	lung-associated mesenchyme development (GO:0060484)	2.49622780
62	Wnt signaling pathway, planar cell polarity pathway (GO:0060071)	2.49570156
63	regulation of glycogen (starch) synthase activity (GO:2000465)	2.47874245
64	spinal cord association neuron differentiation (GO:0021527)	2.43989919
65	neuron migration (GO:0001764)	2.42685963
66	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	2.41907712
67	positive regulation of gastrulation (GO:2000543)	2.40093210
68	vocalization behavior (GO:0071625)	2.38717277
69	forebrain neuron differentiation (GO:0021879)	2.38539859
70	cochlea morphogenesis (GO:0090103)	2.37880357
71	peripheral nervous system axon ensheathment (GO:0032292)	2.35748951
72	myelination in peripheral nervous system (GO:0022011)	2.35748951
73	behavioral response to nicotine (GO:0035095)	2.35672437
74	tongue development (GO:0043586)	2.34564777
75	ephrin receptor signaling pathway (GO:0048013)	2.34451316
76	establishment of planar polarity (GO:0001736)	2.34234041
77	establishment of tissue polarity (GO:0007164)	2.34234041
78	kidney mesenchyme development (GO:0072074)	2.33187821
79	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.33032722
80	regulation of establishment of planar polarity (GO:0090175)	2.33022992
81	regulation of neuron migration (GO:2001222)	2.30892183
82	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.30139407
83	regulation of NFAT protein import into nucleus (GO:0051532)	2.29452919
84	neurotransmitter-gated ion channel clustering (GO:0072578)	2.29288289
85	axon ensheathment in central nervous system (GO:0032291)	2.28211931
86	central nervous system myelination (GO:0022010)	2.28211931
87	positive regulation of neuroblast proliferation (GO:0002052)	2.27295603
88	central nervous system neuron axonogenesis (GO:0021955)	2.25992588
89	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.25536839
90	metanephric mesenchyme development (GO:0072075)	2.24887922
91	auditory behavior (GO:0031223)	2.24250943
92	regulation of synapse assembly (GO:0051963)	2.22551434
93	heart valve formation (GO:0003188)	2.20552907
94	non-canonical Wnt signaling pathway (GO:0035567)	2.20486300
95	bone trabecula formation (GO:0060346)	2.19947260
96	artery development (GO:0060840)	2.19914531
97	apical protein localization (GO:0045176)	2.19904761
98	regulation of glutamate receptor signaling pathway (GO:1900449)	2.19723147
99	skeletal muscle organ development (GO:0060538)	2.18516196
100	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.17353661

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.51143436
2	EZH2_27304074_Chip-Seq_ESCs_Mouse	3.25464625
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.11220724
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.95702878
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.90738147
6	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.84451407
7	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.84451407
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.78826661
9	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.76676914
10	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.67079662
11	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.63676403
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.49242113
13	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.39506775
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.36458774
15	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.35080451
16	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.34187040
17	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.26575057
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.24016606
19	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.22520796
20	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.20224806
21	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.13195799
22	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.11499893
23	TP53_20018659_ChIP-ChIP_R1E_Mouse	2.09206386
24	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	2.08700772
25	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.06553876
26	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.01544925
27	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	2.01131423
28	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.94834158
29	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.92078042
30	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.91285090
31	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.83564470
32	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.82675038
33	REST_21632747_ChIP-Seq_MESCs_Mouse	1.82370219
34	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.80972737
35	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.77371600
36	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.77160996
37	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.73090775
38	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.72727113
39	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.70780708
40	* KDM2B_26808549_Chip-Seq_K562_Human	1.68426649
41	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.65328242
42	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.64378260
43	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60437072
44	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57723645
45	RNF2_27304074_Chip-Seq_NSC_Mouse	1.56988359
46	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.47840823
47	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.44326180
48	* CTCF_27219007_Chip-Seq_Bcells_Human	1.40223852
49	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.38044360
50	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36904408
51	DROSHA_22980978_ChIP-Seq_HELA_Human	1.35210330
52	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.28545845
53	AR_21572438_ChIP-Seq_LNCaP_Human	1.23229361
54	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.21799541
55	GBX2_23144817_ChIP-Seq_PC3_Human	1.21016729
56	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.19101885
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.18551759
58	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.13645849
59	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.13261565
60	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.11704014
61	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.11338816
62	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.11028005
63	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.07052476
64	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	1.05838097
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.03954243
66	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.03259876
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02955810
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02955810
69	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00545172
70	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.99911520
71	* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.99528482
72	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	0.98588605
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.94843314
74	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.93600225
75	SOX3_22085726_ChIP-Seq_NPCs_Mouse	0.92923671
76	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.92890183
77	* KDM2B_26808549_Chip-Seq_JURKAT_Human	0.91532114
78	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.91095543
79	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.90399169
80	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.90252942
81	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90175966
82	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.89691821
83	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.87793672
84	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.85831147
85	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.85734981
86	MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse	0.85553973
87	TCF3_18347094_ChIP-ChIP_MESCs_Mouse	0.85316428
88	AR_19668381_ChIP-Seq_PC3_Human	0.83838949
89	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.83716898
90	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.83064598
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.82986786
92	* SMAD3_21741376_ChIP-Seq_ESCs_Human	0.82432400
93	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.82239393
94	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.80338465
95	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.79844030
96	SOX9_26525672_Chip-Seq_HEART_Mouse	0.79212229
97	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.78825317
98	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.76446961
99	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.76413023
100	* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.76217159

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000778_abnormal_nervous_system	2.82574607
2	MP0000566_synostosis	2.79349079
3	MP0010030_abnormal_orbit_morphology	2.69870327
4	MP0004859_abnormal_synaptic_plasticity	2.46262355
5	MP0000537_abnormal_urethra_morphology	2.13157646
6	MP0003123_paternal_imprinting	2.10178651
7	MP0006292_abnormal_olfactory_placode	2.05635664
8	MP0003122_maternal_imprinting	2.04048593
9	MP0000049_abnormal_middle_ear	2.03272583
10	MP0005423_abnormal_somatic_nervous	2.00685116
11	MP0009379_abnormal_foot_pigmentation	1.91772596
12	MP0001299_abnormal_eye_distance/	1.85675236
13	MP0006276_abnormal_autonomic_nervous	1.85446084
14	MP0003880_abnormal_central_pattern	1.84921040
15	MP0003942_abnormal_urinary_system	1.84785790
16	MP0003890_abnormal_embryonic-extraembry	1.77913820
17	MP0002184_abnormal_innervation	1.75953810
18	MP0000534_abnormal_ureter_morphology	1.75541853
19	MP0003385_abnormal_body_wall	1.74105060
20	MP0005257_abnormal_intraocular_pressure	1.73693314
21	MP0009053_abnormal_anal_canal	1.69434232
22	MP0000955_abnormal_spinal_cord	1.67169013
23	MP0009250_abnormal_appendicular_skeleto	1.58484917
24	MP0004270_analgesia	1.58474764
25	MP0002249_abnormal_larynx_morphology	1.56831700
26	MP0001188_hyperpigmentation	1.55262522
27	MP0005394_taste/olfaction_phenotype	1.55140744
28	MP0005499_abnormal_olfactory_system	1.55140744
29	MP0003861_abnormal_nervous_system	1.54567430
30	MP0003635_abnormal_synaptic_transmissio	1.54358441
31	MP0003119_abnormal_digestive_system	1.54218039
32	MP0003787_abnormal_imprinting	1.51533292
33	MP0003121_genomic_imprinting	1.50967782
34	MP0003937_abnormal_limbs/digits/tail_de	1.49733619
35	MP0002233_abnormal_nose_morphology	1.49485534
36	MP0003283_abnormal_digestive_organ	1.48058860
37	MP0008789_abnormal_olfactory_epithelium	1.46776217
38	MP0003755_abnormal_palate_morphology	1.40439242
39	MP0003315_abnormal_perineum_morphology	1.39562960
40	MP0000428_abnormal_craniofacial_morphol	1.38485250
41	MP0003938_abnormal_ear_development	1.36521197
42	MP0001293_anophthalmia	1.36179418
43	MP0002697_abnormal_eye_size	1.35910823
44	MP0004133_heterotaxia	1.35893755
45	MP0002063_abnormal_learning/memory/cond	1.34502633
46	MP0005503_abnormal_tendon_morphology	1.29661442
47	MP0005409_darkened_coat_color	1.29422797
48	MP0010368_abnormal_lymphatic_system	1.28550205
49	MP0003705_abnormal_hypodermis_morpholog	1.28495625
50	MP0002152_abnormal_brain_morphology	1.27857686
51	MP0002116_abnormal_craniofacial_bone	1.27204861
52	MP0004858_abnormal_nervous_system	1.26552479
53	MP0002734_abnormal_mechanical_nocicepti	1.26174290
54	MP0008438_abnormal_cutaneous_collagen	1.22475235
55	MP0002092_abnormal_eye_morphology	1.22288827
56	MP0002882_abnormal_neuron_morphology	1.21340837
57	MP0004811_abnormal_neuron_physiology	1.19566700
58	MP0001346_abnormal_lacrimal_gland	1.17335099
59	MP0003935_abnormal_craniofacial_develop	1.17290959
60	MP0004272_abnormal_basement_membrane	1.16825694
61	MP0001286_abnormal_eye_development	1.14999428
62	MP0002752_abnormal_somatic_nervous	1.11012346
63	MP0004885_abnormal_endolymph	1.09227392
64	MP0002938_white_spotting	1.08616748
65	MP0002081_perinatal_lethality	1.08252059
66	MP0003136_yellow_coat_color	1.07063045
67	MP0002932_abnormal_joint_morphology	1.06316693
68	MP0002557_abnormal_social/conspecific_i	1.05741683
69	MP0005187_abnormal_penis_morphology	1.05714424
70	MP0002653_abnormal_ependyma_morphology	1.05192093
71	MP0002572_abnormal_emotion/affect_behav	1.04863968
72	MP0005623_abnormal_meninges_morphology	1.03775678
73	MP0000631_abnormal_neuroendocrine_gland	1.03613784
74	MP0001529_abnormal_vocalization	1.03239888
75	MP0000026_abnormal_inner_ear	0.98604933
76	MP0003115_abnormal_respiratory_system	0.95497096
77	MP0005248_abnormal_Harderian_gland	0.95104299
78	MP0000462_abnormal_digestive_system	0.94543070
79	MP0002751_abnormal_autonomic_nervous	0.93442052
80	MP0001984_abnormal_olfaction	0.91243996
81	MP0001879_abnormal_lymphatic_vessel	0.89955842
82	MP0000432_abnormal_head_morphology	0.88326558
83	MP0002272_abnormal_nervous_system	0.86695716
84	MP0002114_abnormal_axial_skeleton	0.86552716
85	MP0003567_abnormal_fetal_cardiomyocyte	0.86340143
86	MP0002822_catalepsy	0.86293490
87	MP0000762_abnormal_tongue_morphology	0.85678618
88	MP0002111_abnormal_tail_morphology	0.84297307
89	MP0002084_abnormal_developmental_patter	0.81798801
90	MP0005508_abnormal_skeleton_morphology	0.81656958
91	MP0009672_abnormal_birth_weight	0.81063108
92	MP0002085_abnormal_embryonic_tissue	0.80868958
93	MP0001502_abnormal_circadian_rhythm	0.80668155
94	MP0009384_cardiac_valve_regurgitation	0.79644539
95	MP0005391_vision/eye_phenotype	0.79476006
96	MP0001440_abnormal_grooming_behavior	0.78529912
97	MP0001177_atelectasis	0.76318597
98	MP0001970_abnormal_pain_threshold	0.76043712
99	MP0002735_abnormal_chemical_nociception	0.76026501
100	MP0005195_abnormal_posterior_eye	0.75982775

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Short 4th metacarpal (HP:0010044)	3.18482456
2	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	3.18482456
3	Turricephaly (HP:0000262)	3.13371635
4	Broad metatarsal (HP:0001783)	2.89913082
5	Shallow orbits (HP:0000586)	2.83015634
6	High anterior hairline (HP:0009890)	2.78345418
7	Coronal craniosynostosis (HP:0004440)	2.77861978
8	Abnormality of the 4th metacarpal (HP:0010012)	2.67921325
9	Abnormality of the aortic arch (HP:0012303)	2.66697787
10	Cutaneous finger syndactyly (HP:0010554)	2.64476570
11	Myokymia (HP:0002411)	2.62690291
12	Cutaneous syndactyly (HP:0012725)	2.58785759
13	Hepatoblastoma (HP:0002884)	2.55770896
14	Partial duplication of the phalanx of hand (HP:0009999)	2.47613240
15	Partial duplication of thumb phalanx (HP:0009944)	2.41402166
16	Aplasia involving bones of the upper limbs (HP:0009823)	2.32819537
17	Aplasia of the phalanges of the hand (HP:0009802)	2.32819537
18	Aplasia involving bones of the extremities (HP:0009825)	2.32819537
19	Shawl scrotum (HP:0000049)	2.28469674
20	Septo-optic dysplasia (HP:0100842)	2.27952270
21	Hypoventilation (HP:0002791)	2.17599342
22	Rib fusion (HP:0000902)	2.11262561
23	Hyperacusis (HP:0010780)	2.05251949
24	Renovascular hypertension (HP:0100817)	2.04600726
25	Vitreoretinal degeneration (HP:0000655)	2.03503047
26	Protrusio acetabuli (HP:0003179)	2.01879306
27	Abnormality of the labia minora (HP:0012880)	2.01394290
28	Megalencephaly (HP:0001355)	2.00790124
29	Bowel diverticulosis (HP:0005222)	2.00407767
30	Bladder diverticulum (HP:0000015)	2.00163016
31	Morphological abnormality of the middle ear (HP:0008609)	1.98395674
32	Renal duplication (HP:0000075)	1.96102260
33	Trigonocephaly (HP:0000243)	1.92709117
34	Overriding aorta (HP:0002623)	1.91801858
35	Genu recurvatum (HP:0002816)	1.90122981
36	Neonatal short-limb short stature (HP:0008921)	1.89967669
37	Broad thumb (HP:0011304)	1.89396040
38	Cortical dysplasia (HP:0002539)	1.88855274
39	Calcaneovalgus deformity (HP:0001848)	1.87287505
40	Overgrowth (HP:0001548)	1.87112406
41	Ulnar bowing (HP:0003031)	1.86457686
42	Wide anterior fontanel (HP:0000260)	1.86359946
43	Midline defect of the nose (HP:0004122)	1.86084378
44	Broad finger (HP:0001500)	1.85798562
45	Buphthalmos (HP:0000557)	1.84559303
46	Esophageal atresia (HP:0002032)	1.84363171
47	Broad long bones (HP:0005622)	1.83987232
48	Broad phalanges of the hand (HP:0009768)	1.82299696
49	Drooling (HP:0002307)	1.82188758
50	Premature rupture of membranes (HP:0001788)	1.81585269
51	Insomnia (HP:0100785)	1.81478004
52	Deep palmar crease (HP:0006191)	1.81304180
53	Abnormality of the phalanges of the hallux (HP:0010057)	1.79068812
54	Preaxial foot polydactyly (HP:0001841)	1.78465332
55	Broad phalanx (HP:0006009)	1.77850560
56	Arnold-Chiari malformation (HP:0002308)	1.76177065
57	Deformed tarsal bones (HP:0008119)	1.75611544
58	Elfin facies (HP:0004428)	1.75362358
59	Thin ribs (HP:0000883)	1.74860380
60	Megalocornea (HP:0000485)	1.74135425
61	Abnormality of dentin (HP:0010299)	1.72688575
62	Bronchomalacia (HP:0002780)	1.67866234
63	Abnormality of the diencephalon (HP:0010662)	1.65953036
64	Pointed chin (HP:0000307)	1.65737071
65	Anophthalmia (HP:0000528)	1.65519675
66	Sleep apnea (HP:0010535)	1.64846362
67	Abnormal number of incisors (HP:0011064)	1.64704328
68	Vertebral arch anomaly (HP:0008438)	1.63371553
69	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.63217352
70	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.62340170
71	Hypoplasia of the brainstem (HP:0002365)	1.62340170
72	Choanal stenosis (HP:0000452)	1.62325240
73	Abnormality of the lower motor neuron (HP:0002366)	1.58922183
74	Spinal rigidity (HP:0003306)	1.58715356
75	Broad hallux (HP:0010055)	1.58383904
76	Narrow nasal bridge (HP:0000446)	1.57877982
77	Abnormality of the calcaneus (HP:0008364)	1.56627449
78	Excessive salivation (HP:0003781)	1.55238234
79	Deviation of the hallux (HP:0010051)	1.54679453
80	Hypoplasia of the maxilla (HP:0000327)	1.54282598
81	Abnormality of the antihelix (HP:0009738)	1.51908653
82	Broad toe (HP:0001837)	1.51380548
83	Duplication of thumb phalanx (HP:0009942)	1.51195828
84	Abnormality of the incisor (HP:0000676)	1.50424753
85	Flat cornea (HP:0007720)	1.50319083
86	Optic nerve hypoplasia (HP:0000609)	1.49984839
87	Enlarged penis (HP:0000040)	1.49655589
88	Renal dysplasia (HP:0000110)	1.49263869
89	Abnormality of the parietal bone (HP:0002696)	1.48623452
90	Abdominal situs inversus (HP:0003363)	1.48109174
91	Abnormality of abdominal situs (HP:0011620)	1.48109174
92	Short palpebral fissure (HP:0012745)	1.46942525
93	Obstructive sleep apnea (HP:0002870)	1.46889280
94	Omphalocele (HP:0001539)	1.46792204
95	Diastasis recti (HP:0001540)	1.46115769
96	Facial hemangioma (HP:0000329)	1.45773927
97	Hallux valgus (HP:0001822)	1.45639538
98	Spina bifida occulta (HP:0003298)	1.45307801
99	Exotropia (HP:0000577)	1.44658734
100	Skull defect (HP:0001362)	1.44341546

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	4.30987381
2	EPHB2	3.65413004
3	CASK	3.47967371
4	LATS2	2.58075156
5	NTRK2	2.32281767
6	MAP3K10	2.28433052
7	NTRK1	2.16042091
8	DYRK2	2.11488503
9	TYRO3	2.06102890
10	ICK	2.00037889
11	PNCK	1.99026152
12	MAP3K9	1.73370626
13	NTRK3	1.68777208
14	LATS1	1.68603728
15	TRIB3	1.63275236
16	CAMK1G	1.61474285
17	FGFR2	1.55220102
18	SGK494	1.55186353
19	SGK223	1.55186353
20	EPHA4	1.51995367
21	PDGFRA	1.49325612
22	PINK1	1.48203160
23	MAP2K7	1.44181279
24	MINK1	1.38375326
25	EEF2K	1.36600995
26	CAMK1D	1.25559112
27	SIK2	1.24414083
28	DYRK3	1.19588356
29	SGK2	1.17640697
30	MAP3K4	1.17525076
31	NEK2	1.15752568
32	PRKD3	1.11377234
33	DYRK1B	1.11164317
34	KSR1	1.09824302
35	SGK3	1.07604162
36	RPS6KA2	1.07568542
37	MARK2	1.03912637
38	DDR2	1.02294754
39	TIE1	1.01434046
40	CSNK1G2	0.99272278
41	TNIK	0.98211817
42	STK38L	0.97998397
43	RIPK1	0.95707207
44	MTOR	0.93425220
45	WNK4	0.92841627
46	PRKCG	0.92303843
47	MKNK2	0.91356654
48	PAK6	0.89829438
49	PKN2	0.88940517
50	SIK1	0.84121715
51	CDK19	0.84068497
52	UHMK1	0.83572330
53	CDK5	0.82600982
54	MKNK1	0.80616964
55	BRAF	0.77131920
56	WNK3	0.73517803
57	MAPK15	0.72947174
58	MAPK13	0.72929070
59	CDK14	0.69611715
60	PTK2	0.68629552
61	CAMK1	0.66855264
62	MAP2K4	0.66738954
63	CDK15	0.65804810
64	CDK11A	0.65493782
65	STK11	0.62745014
66	BCR	0.61716662
67	AKT3	0.61358107
68	PDGFRB	0.60747025
69	PRKCH	0.60637427
70	CSNK1E	0.60533788
71	DYRK1A	0.60485431
72	CSNK1G3	0.60242808
73	CSNK1G1	0.59716039
74	CDK18	0.59066325
75	WNK1	0.58750163
76	PAK3	0.56648028
77	CDC7	0.56265028
78	RPS6KL1	0.54428475
79	RPS6KC1	0.54428475
80	DMPK	0.53770450
81	PKN1	0.53738088
82	PAK2	0.53433888
83	CSNK1A1L	0.52648658
84	IRAK2	0.50585886
85	RPS6KA6	0.50344973
86	CAMK4	0.50216693
87	CDK3	0.47554912
88	PRKAA1	0.47550751
89	GSK3B	0.45562772
90	PHKG1	0.45356465
91	PHKG2	0.45356465
92	AURKA	0.44322274
93	CHEK2	0.43164559
94	RET	0.42677882
95	AKT1	0.41668205
96	PRKDC	0.41063105
97	PRKCZ	0.40550856
98	TAF1	0.39899368
99	STK38	0.39697978
100	SGK1	0.39206402

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal cell carcinoma_Homo sapiens_hsa05217	2.64485751
2	Axon guidance_Homo sapiens_hsa04360	2.49573026
3	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.44898562
4	Nicotine addiction_Homo sapiens_hsa05033	2.10427940
5	Hippo signaling pathway_Homo sapiens_hsa04390	1.92990639
6	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.82816517
7	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.74202727
8	Cocaine addiction_Homo sapiens_hsa05030	1.71320698
9	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.70492481
10	Melanogenesis_Homo sapiens_hsa04916	1.70323218
11	Wnt signaling pathway_Homo sapiens_hsa04310	1.68697568
12	Circadian entrainment_Homo sapiens_hsa04713	1.57871347
13	Gap junction_Homo sapiens_hsa04540	1.56429585
14	Notch signaling pathway_Homo sapiens_hsa04330	1.56016222
15	Glutamatergic synapse_Homo sapiens_hsa04724	1.55932220
16	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.51224789
17	ECM-receptor interaction_Homo sapiens_hsa04512	1.47290303
18	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.46276814
19	Dopaminergic synapse_Homo sapiens_hsa04728	1.43636985
20	Cholinergic synapse_Homo sapiens_hsa04725	1.42830731
21	GABAergic synapse_Homo sapiens_hsa04727	1.40224551
22	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.39560118
23	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.37725744
24	Morphine addiction_Homo sapiens_hsa05032	1.33290411
25	Endometrial cancer_Homo sapiens_hsa05213	1.29114419
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28540255
27	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.21552413
28	Insulin secretion_Homo sapiens_hsa04911	1.16562297
29	ErbB signaling pathway_Homo sapiens_hsa04012	1.16142052
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16126071
31	Colorectal cancer_Homo sapiens_hsa05210	1.14792439
32	Long-term potentiation_Homo sapiens_hsa04720	1.13911655
33	Amphetamine addiction_Homo sapiens_hsa05031	1.11171222
34	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.10783309
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.10350144
36	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.05228065
37	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.04846375
38	Focal adhesion_Homo sapiens_hsa04510	1.04077232
39	Long-term depression_Homo sapiens_hsa04730	1.02615895
40	Glioma_Homo sapiens_hsa05214	1.02600264
41	Melanoma_Homo sapiens_hsa05218	1.01691429
42	MicroRNAs in cancer_Homo sapiens_hsa05206	0.98096949
43	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.96629813
44	Rap1 signaling pathway_Homo sapiens_hsa04015	0.95921377
45	Alcoholism_Homo sapiens_hsa05034	0.95256900
46	Adherens junction_Homo sapiens_hsa04520	0.95067718
47	cAMP signaling pathway_Homo sapiens_hsa04024	0.94174673
48	Ribosome_Homo sapiens_hsa03010	0.93765155
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93167228
50	Estrogen signaling pathway_Homo sapiens_hsa04915	0.92631215
51	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.91206406
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88299136
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.87720732
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.87673097
55	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.86956331
56	Protein digestion and absorption_Homo sapiens_hsa04974	0.84729361
57	Pathways in cancer_Homo sapiens_hsa05200	0.84439097
58	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.84009536
59	Ras signaling pathway_Homo sapiens_hsa04014	0.83436422
60	Tight junction_Homo sapiens_hsa04530	0.83270614
61	Lysine degradation_Homo sapiens_hsa00310	0.82954960
62	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.82718084
63	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.82683243
64	Gastric acid secretion_Homo sapiens_hsa04971	0.81153891
65	MAPK signaling pathway_Homo sapiens_hsa04010	0.75095806
66	AMPK signaling pathway_Homo sapiens_hsa04152	0.75086631
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.74464570
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.73854471
69	Proteoglycans in cancer_Homo sapiens_hsa05205	0.73256053
70	Renin secretion_Homo sapiens_hsa04924	0.72351596
71	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.71149997
72	VEGF signaling pathway_Homo sapiens_hsa04370	0.70564387
73	Prion diseases_Homo sapiens_hsa05020	0.69883783
74	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69491805
75	Serotonergic synapse_Homo sapiens_hsa04726	0.68950606
76	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.68631854
77	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.67654293
78	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.66858860
79	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.66540590
80	Taste transduction_Homo sapiens_hsa04742	0.66496544
81	Renal cell carcinoma_Homo sapiens_hsa05211	0.65038140
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.64027914
83	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.63646925
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.62241097
85	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.60992243
86	Prostate cancer_Homo sapiens_hsa05215	0.58907126
87	Insulin signaling pathway_Homo sapiens_hsa04910	0.57630719
88	Oocyte meiosis_Homo sapiens_hsa04114	0.56752385
89	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56308529
90	Olfactory transduction_Homo sapiens_hsa04740	0.56191306
91	Phototransduction_Homo sapiens_hsa04744	0.55883067
92	Cell cycle_Homo sapiens_hsa04110	0.54748325
93	Salivary secretion_Homo sapiens_hsa04970	0.53929967
94	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.53903503
95	Sulfur relay system_Homo sapiens_hsa04122	0.53886915
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.53814494
97	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.53402395
98	Choline metabolism in cancer_Homo sapiens_hsa05231	0.53173604
99	Glucagon signaling pathway_Homo sapiens_hsa04922	0.51929890
100	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.49968923

C11ORF95

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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