ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	vitamin A metabolic process (GO:0006776)	5.21714032
2	low-density lipoprotein particle clearance (GO:0034383)	4.78215871
3	adhesion of symbiont to host (GO:0044406)	4.36009331
4	cell migration involved in heart development (GO:0060973)	4.22179334
5	glucocorticoid biosynthetic process (GO:0006704)	4.13244782
6	endocardial cushion morphogenesis (GO:0003203)	4.02781647
7	endothelial cell chemotaxis (GO:0035767)	3.76342507
8	regulation of gonadotropin secretion (GO:0032276)	3.60732290
9	glomerular filtration (GO:0003094)	3.53374623
10	atrioventricular valve morphogenesis (GO:0003181)	3.47084582
11	cellular response to cadmium ion (GO:0071276)	3.44500666
12	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	3.34598140
13	mesenchyme morphogenesis (GO:0072132)	3.33706310
14	positive regulation of p38MAPK cascade (GO:1900745)	3.33578099
15	potassium ion import (GO:0010107)	3.25721055
16	smooth muscle tissue development (GO:0048745)	3.24545531
17	lymph vessel development (GO:0001945)	3.20886238
18	extracellular matrix assembly (GO:0085029)	3.17822670
19	dermatan sulfate biosynthetic process (GO:0030208)	3.16939003
20	renal filtration (GO:0097205)	3.08204698
21	Notch signaling involved in heart development (GO:0061314)	3.06484219
22	cGMP-mediated signaling (GO:0019934)	3.06440863
23	cellular response to vascular endothelial growth factor stimulus (GO:0035924)	3.06420126
24	dermatan sulfate metabolic process (GO:0030205)	3.06152725
25	negative regulation of homotypic cell-cell adhesion (GO:0034111)	3.02855784
26	cellular response to gonadotropin stimulus (GO:0071371)	3.01634216
27	regulation of p38MAPK cascade (GO:1900744)	2.99519917
28	positive regulation of astrocyte differentiation (GO:0048711)	2.97575737
29	ovulation from ovarian follicle (GO:0001542)	2.97318325
30	cellular response to zinc ion (GO:0071294)	2.96543515
31	cellular response to epinephrine stimulus (GO:0071872)	2.95043875
32	regulation of cholesterol storage (GO:0010885)	2.94906402
33	negative regulation of macrophage differentiation (GO:0045650)	2.94450806
34	glucocorticoid metabolic process (GO:0008211)	2.87649049
35	adhesion of symbiont to host cell (GO:0044650)	2.86754617
36	virion attachment to host cell (GO:0019062)	2.86754617
37	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.82502857
38	kidney mesenchyme development (GO:0072074)	2.79598224
39	keratan sulfate catabolic process (GO:0042340)	2.76478381
40	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	2.75030479
41	regulation of protein polyubiquitination (GO:1902914)	2.72518809
42	negative regulation of platelet activation (GO:0010544)	2.72321969
43	heart valve morphogenesis (GO:0003179)	2.69572522
44	basement membrane organization (GO:0071711)	2.66886653
45	cell volume homeostasis (GO:0006884)	2.66837559
46	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.66340409
47	negative regulation of catenin import into nucleus (GO:0035414)	2.65862392
48	mesenchymal cell development (GO:0014031)	2.65282656
49	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.65057788
50	androgen biosynthetic process (GO:0006702)	2.64752568
51	surfactant homeostasis (GO:0043129)	2.59102835
52	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.58076044
53	heart trabecula formation (GO:0060347)	2.57503517
54	cell proliferation involved in metanephros development (GO:0072203)	2.57408074
55	cardiac myofibril assembly (GO:0055003)	2.54135158
56	negative regulation of fatty acid transport (GO:2000192)	2.53760019
57	chondroitin sulfate biosynthetic process (GO:0030206)	2.52325098
58	positive regulation of fatty acid oxidation (GO:0046321)	2.51020359
59	ventricular septum morphogenesis (GO:0060412)	2.50302069
60	sodium ion export (GO:0071436)	2.50045651
61	cGMP biosynthetic process (GO:0006182)	2.48625273
62	phagocytosis, recognition (GO:0006910)	2.48144004
63	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.47849261
64	gamma-aminobutyric acid transport (GO:0015812)	2.46524372
65	vascular endothelial growth factor signaling pathway (GO:0038084)	2.46521308
66	response to follicle-stimulating hormone (GO:0032354)	2.46145739
67	aorta morphogenesis (GO:0035909)	2.45999484
68	cardiac muscle adaptation (GO:0014887)	2.44459947
69	cardiac muscle hypertrophy in response to stress (GO:0014898)	2.44459947
70	muscle hypertrophy in response to stress (GO:0003299)	2.44459947
71	chondrocyte proliferation (GO:0035988)	2.44307748
72	positive regulation of lipid storage (GO:0010884)	2.41675776
73	regulation of transforming growth factor beta2 production (GO:0032909)	2.41162630
74	barbed-end actin filament capping (GO:0051016)	2.40902021
75	vasculature development (GO:0001944)	2.38993586
76	response to epinephrine (GO:0071871)	2.37861766
77	activation of MAPKKK activity (GO:0000185)	2.37365531
78	regulation of triglyceride biosynthetic process (GO:0010866)	2.34062068
79	embryonic camera-type eye morphogenesis (GO:0048596)	2.33080901
80	positive regulation of triglyceride metabolic process (GO:0090208)	2.31985923
81	negative regulation of vascular permeability (GO:0043116)	2.31725585
82	positive regulation of fat cell differentiation (GO:0045600)	2.31711632
83	metanephric mesenchyme development (GO:0072075)	2.31332958
84	heart valve formation (GO:0003188)	2.31070970
85	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	2.30491726
86	regulation of fever generation (GO:0031620)	2.28906162
87	positive regulation of protein kinase C signaling (GO:0090037)	2.28390455
88	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.27230246
89	sodium-independent organic anion transport (GO:0043252)	2.25530443
90	protein heterotrimerization (GO:0070208)	2.25039921
91	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.22963618
92	negative regulation of smooth muscle cell proliferation (GO:0048662)	2.22598364
93	glomerulus development (GO:0032835)	2.22044245
94	cell proliferation involved in kidney development (GO:0072111)	2.20942488
95	myofibril assembly (GO:0030239)	2.19459137
96	potassium ion export (GO:0071435)	2.18940177
97	cardiac muscle hypertrophy (GO:0003300)	2.18360067
98	growth hormone secretion (GO:0030252)	2.17387183
99	artery morphogenesis (GO:0048844)	2.17283458
100	keratan sulfate biosynthetic process (GO:0018146)	2.16959996

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRIM28_21343339_ChIP-Seq_HEK293_Human	3.33298627
2	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.52498326
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	2.40598989
4	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.39365646
5	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.38889904
6	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	2.32187019
7	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.29108983
8	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.29108983
9	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.25002188
10	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.20352244
11	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.18825556
12	CLOCK_20551151_ChIP-Seq_293T_Human	2.10687126
13	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.09394121
14	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.08347473
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.08186941
16	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.07490788
17	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.03460091
18	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.92203305
19	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.92068575
20	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.90999638
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.90902054
22	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.89154700
23	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.87113100
24	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.85049260
25	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.83109843
26	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.81880032
27	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.79720494
28	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.79665006
29	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.77251616
30	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.68866775
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.64316909
32	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.59396794
33	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.57199356
34	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.55230342
35	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.52723539
36	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.50280260
37	KDM2B_26808549_Chip-Seq_K562_Human	1.46071558
38	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.44845091
39	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.43634205
40	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.43508529
41	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.41930746
42	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.40962252
43	LXR_22292898_ChIP-Seq_THP-1_Human	1.35300699
44	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.33035967
45	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.29953534
46	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.29833464
47	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.29394474
48	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.28326489
49	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.28183519
50	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.28095987
51	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.26474066
52	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.25513467
53	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.25513467
54	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.24121398
55	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.20138514
56	DROSHA_22980978_ChIP-Seq_HELA_Human	1.19715075
57	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.18254627
58	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.18232257
59	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.17268926
60	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.16959889
61	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.16887340
62	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.13780328
63	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.12218450
64	SMC1_22415368_ChIP-Seq_MEFs_Mouse	1.11989390
65	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.11259734
66	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.11075634
67	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.10579298
68	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.09830771
69	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.08888683
70	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.08417555
71	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.08247362
72	CJUN_26792858_Chip-Seq_BT549_Human	1.04677485
73	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.03952166
74	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.03320103
75	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.03168807
76	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.02970764
77	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.02765391
78	KDM2B_26808549_Chip-Seq_DND41_Human	0.99171179
79	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.98637009
80	RACK7_27058665_Chip-Seq_MCF-7_Human	0.94728094
81	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.94315822
82	SA1_22415368_ChIP-Seq_MEFs_Mouse	0.94229642
83	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.93991886
84	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.93802200
85	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.92549217
86	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.91927969
87	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.90582858
88	CTCF_27219007_Chip-Seq_Bcells_Human	0.90156006
89	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.87936585
90	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.87516896
91	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.85604077
92	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.85217805
93	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.83742149
94	EGR1_19032775_ChIP-ChIP_M12_Human	0.82063909
95	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.81360661
96	KDM2B_26808549_Chip-Seq_JURKAT_Human	0.81322806
97	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.80182934
98	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.79509241
99	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.78798510
100	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.78798510

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003011_delayed_dark_adaptation	6.21933906
2	MP0008004_abnormal_stomach_pH	3.73756087
3	MP0003283_abnormal_digestive_organ	3.63560558
4	MP0008438_abnormal_cutaneous_collagen	3.03817785
5	MP0003279_aneurysm	2.82746670
6	MP0010368_abnormal_lymphatic_system	2.79438816
7	MP0004272_abnormal_basement_membrane	2.63124746
8	MP0001879_abnormal_lymphatic_vessel	2.30442928
9	MP0005503_abnormal_tendon_morphology	2.29731639
10	MP0009384_cardiac_valve_regurgitation	2.28902497
11	MP0003724_increased_susceptibility_to	2.24619000
12	MP0005595_abnormal_vascular_smooth	2.09897666
13	MP0003705_abnormal_hypodermis_morpholog	2.08973716
14	MP0009840_abnormal_foam_cell	2.01149866
15	MP0005670_abnormal_white_adipose	1.99039396
16	MP0004510_myositis	1.94111498
17	MP0005275_abnormal_skin_tensile	1.92247412
18	MP0005164_abnormal_response_to	1.91339479
19	MP0000343_altered_response_to	1.91039183
20	MP0000767_abnormal_smooth_muscle	1.87511444
21	MP0003303_peritoneal_inflammation	1.84468187
22	MP0005423_abnormal_somatic_nervous	1.78735835
23	MP0005167_abnormal_blood-brain_barrier	1.70972021
24	MP0006138_congestive_heart_failure	1.69414510
25	MP0001958_emphysema	1.66441595
26	MP0005508_abnormal_skeleton_morphology	1.66317947
27	MP0002933_joint_inflammation	1.59014687
28	MP0003091_abnormal_cell_migration	1.56753283
29	MP0002009_preneoplasia	1.51662768
30	MP0002295_abnormal_pulmonary_circulatio	1.45375485
31	MP0003136_yellow_coat_color	1.41013674
32	MP0001986_abnormal_taste_sensitivity	1.40026088
33	MP0000462_abnormal_digestive_system	1.35454697
34	MP0003828_pulmonary_edema	1.33605324
35	MP0005623_abnormal_meninges_morphology	1.33247107
36	MP0004130_abnormal_muscle_cell	1.32563216
37	MP0004883_abnormal_blood_vessel	1.31374089
38	MP0003075_altered_response_to	1.29170708
39	MP0001502_abnormal_circadian_rhythm	1.24232338
40	MP0001501_abnormal_sleep_pattern	1.23403554
41	MP0005620_abnormal_muscle_contractility	1.21108050
42	MP0000249_abnormal_blood_vessel	1.20824605
43	MP0004215_abnormal_myocardial_fiber	1.19976424
44	MP0002127_abnormal_cardiovascular_syste	1.18838461
45	MP0000230_abnormal_systemic_arterial	1.17368846
46	MP0005023_abnormal_wound_healing	1.17188836
47	MP0002972_abnormal_cardiac_muscle	1.16390061
48	MP0004019_abnormal_vitamin_homeostasis	1.16211748
49	MP0005390_skeleton_phenotype	1.15268204
50	MP0002896_abnormal_bone_mineralization	1.14038578
51	MP0000013_abnormal_adipose_tissue	1.13790922
52	MP0000751_myopathy	1.13252674
53	MP0005666_abnormal_adipose_tissue	1.11658526
54	MP0005165_increased_susceptibility_to	1.11310426
55	MP0009250_abnormal_appendicular_skeleto	1.09797619
56	MP0004084_abnormal_cardiac_muscle	1.08816732
57	MP0001851_eye_inflammation	1.07916901
58	MP0002998_abnormal_bone_remodeling	1.06319579
59	MP0005334_abnormal_fat_pad	1.04144410
60	MP0004782_abnormal_surfactant_physiolog	1.02102869
61	MP0004858_abnormal_nervous_system	1.02051416
62	MP0005330_cardiomyopathy	1.00322745
63	MP0005375_adipose_tissue_phenotype	0.99382311
64	MP0008775_abnormal_heart_ventricle	0.99161717
65	MP0002332_abnormal_exercise_endurance	0.97231807
66	MP0005166_decreased_susceptibility_to	0.95900044
67	MP0004085_abnormal_heartbeat	0.93530824
68	MP0005253_abnormal_eye_physiology	0.92542900
69	MP0002971_abnormal_brown_adipose	0.88566277
70	MP0002108_abnormal_muscle_morphology	0.88260526
71	MP0005409_darkened_coat_color	0.86693758
72	MP0003690_abnormal_glial_cell	0.84854271
73	MP0005448_abnormal_energy_balance	0.84536573
74	MP0001533_abnormal_skeleton_physiology	0.84469408
75	MP0000639_abnormal_adrenal_gland	0.83768461
76	MP0010329_abnormal_lipoprotein_level	0.81698498
77	MP0001661_extended_life_span	0.81246480
78	MP0002128_abnormal_blood_circulation	0.77914104
79	MP0005385_cardiovascular_system_phenoty	0.76823706
80	MP0001544_abnormal_cardiovascular_syste	0.76823706
81	MP0005535_abnormal_body_temperature	0.75337020
82	MP0001664_abnormal_digestion	0.73913127
83	MP0009115_abnormal_fat_cell	0.73740741
84	MP0001881_abnormal_mammary_gland	0.73688160
85	MP0001614_abnormal_blood_vessel	0.72758430
86	MP0003045_fibrosis	0.70623849
87	MP0000534_abnormal_ureter_morphology	0.68123993
88	MP0005647_abnormal_sex_gland	0.67011984
89	MP0003300_gastrointestinal_ulcer	0.66725602
90	MP0000163_abnormal_cartilage_morphology	0.66381173
91	MP0002909_abnormal_adrenal_gland	0.64732476
92	MP0003634_abnormal_glial_cell	0.64717446
93	MP0003329_amyloid_beta_deposits	0.64539396
94	MP0001270_distended_abdomen	0.63837889
95	MP0009764_decreased_sensitivity_to	0.63759421
96	MP0005076_abnormal_cell_differentiation	0.63727386
97	MP0004036_abnormal_muscle_relaxation	0.62527757
98	MP0000049_abnormal_middle_ear	0.62014484
99	MP0002249_abnormal_larynx_morphology	0.60744711
100	MP0004087_abnormal_muscle_fiber	0.60115559

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Complement deficiency (HP:0004431)	4.46255717
2	Systemic lupus erythematosus (HP:0002725)	4.32842336
3	Abnormality of complement system (HP:0005339)	3.85244017
4	Axonal loss (HP:0003447)	3.76467990
5	Protrusio acetabuli (HP:0003179)	3.62802969
6	Short hallux (HP:0010109)	3.50644789
7	Aortic aneurysm (HP:0004942)	3.50278785
8	Ulnar claw (HP:0001178)	3.42493155
9	Bone cyst (HP:0012062)	3.26645859
10	Pulmonary artery stenosis (HP:0004415)	3.24781845
11	Broad metatarsal (HP:0001783)	3.15047609
12	Aplasia/Hypoplasia of the hallux (HP:0008362)	3.11546833
13	Cerebral aneurysm (HP:0004944)	3.09663338
14	Glomerulonephritis (HP:0000099)	3.01890321
15	Abnormality of the phalanges of the hallux (HP:0010057)	2.94366736
16	Shallow orbits (HP:0000586)	2.82685031
17	Hypoplasia of the iris (HP:0007676)	2.78288417
18	Segmental peripheral demyelination/remyelination (HP:0003481)	2.78215824
19	Muscle fiber splitting (HP:0003555)	2.66863089
20	Relative macrocephaly (HP:0004482)	2.65575815
21	Mesangial abnormality (HP:0001966)	2.59339279
22	Abnormality of the pulmonary veins (HP:0011718)	2.56746341
23	Interstitial pulmonary disease (HP:0006530)	2.53997187
24	Hypercortisolism (HP:0001578)	2.51145350
25	Anomalous pulmonary venous return (HP:0010772)	2.50636096
26	Accelerated skeletal maturation (HP:0005616)	2.46948774
27	Hypertriglyceridemia (HP:0002155)	2.42171688
28	Abnormality of the 2nd finger (HP:0004100)	2.40338555
29	Premature rupture of membranes (HP:0001788)	2.40101856
30	Atrial fibrillation (HP:0005110)	2.38841261
31	Overgrowth (HP:0001548)	2.37563472
32	Prominent supraorbital ridges (HP:0000336)	2.35021231
33	Spinal rigidity (HP:0003306)	2.34993779
34	Supraventricular arrhythmia (HP:0005115)	2.34294979
35	Wormian bones (HP:0002645)	2.33106723
36	Choroideremia (HP:0001139)	2.32794573
37	Scotoma (HP:0000575)	2.30315453
38	Growth hormone excess (HP:0000845)	2.29235014
39	Congenital stationary night blindness (HP:0007642)	2.28108681
40	Primary atrial arrhythmia (HP:0001692)	2.21495497
41	Flared iliac wings (HP:0002869)	2.21244667
42	Ectopia lentis (HP:0001083)	2.18723922
43	Asymmetric septal hypertrophy (HP:0001670)	2.15975076
44	Turricephaly (HP:0000262)	2.12634771
45	Supraventricular tachycardia (HP:0004755)	2.12444094
46	Acanthosis nigricans (HP:0000956)	2.12101534
47	Coxa vara (HP:0002812)	2.10388087
48	Ovoid vertebral bodies (HP:0003300)	2.08134259
49	Absent toe (HP:0010760)	2.06338272
50	Nephritis (HP:0000123)	2.04058278
51	Aortic dissection (HP:0002647)	2.03385438
52	Abnormality of carpal bone ossification (HP:0006257)	2.02498896
53	Large earlobe (HP:0009748)	2.00366235
54	Neurofibrillary tangles (HP:0002185)	1.99651921
55	Abnormal ossification of hand bones (HP:0005921)	1.98646848
56	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98607612
57	Increased variability in muscle fiber diameter (HP:0003557)	1.98287822
58	Stroke (HP:0001297)	1.97667351
59	Distal lower limb muscle weakness (HP:0009053)	1.97496646
60	Vertebral arch anomaly (HP:0008438)	1.95940046
61	Mitral stenosis (HP:0001718)	1.95551156
62	Increased connective tissue (HP:0009025)	1.95384389
63	Hemorrhage of the eye (HP:0011885)	1.93631315
64	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.93476558
65	Abnormality of the anterior chamber (HP:0000593)	1.93461125
66	Large for gestational age (HP:0001520)	1.92475662
67	Hyporeflexia of lower limbs (HP:0002600)	1.92321746
68	Cupped ribs (HP:0000887)	1.92303251
69	Vascular tortuosity (HP:0004948)	1.90932494
70	Ureteral duplication (HP:0000073)	1.89847224
71	Peripheral hypomyelination (HP:0007182)	1.88158243
72	Patent foramen ovale (HP:0001655)	1.86188474
73	Action tremor (HP:0002345)	1.86085749
74	Ventricular fibrillation (HP:0001663)	1.84747085
75	Hemiplegia (HP:0002301)	1.83612760
76	Polycythemia (HP:0001901)	1.83336978
77	Type 1 muscle fiber predominance (HP:0003803)	1.82115351
78	Abnormality of the vertebral endplates (HP:0005106)	1.80248621
79	Wrist flexion contracture (HP:0001239)	1.78922892
80	Aortic regurgitation (HP:0001659)	1.78869785
81	Aneurysm (HP:0002617)	1.78051666
82	Preauricular pit (HP:0004467)	1.75175987
83	Periauricular skin pits (HP:0100277)	1.75175987
84	Prolonged QT interval (HP:0001657)	1.73841912
85	Abnormal hand bone ossification (HP:0010660)	1.73335618
86	Preaxial foot polydactyly (HP:0001841)	1.73324865
87	Aortic valve stenosis (HP:0001650)	1.72872474
88	Xanthomatosis (HP:0000991)	1.72454602
89	Venous abnormality (HP:0002624)	1.71495910
90	Syncope (HP:0001279)	1.71476120
91	Hypoventilation (HP:0002791)	1.70672659
92	Short femoral neck (HP:0100864)	1.70483393
93	Polar cataract (HP:0010696)	1.69083057
94	Subcapsular cataract (HP:0000523)	1.68439371
95	Gonadal dysgenesis (HP:0000133)	1.67810743
96	Bulbar palsy (HP:0001283)	1.66581215
97	Adrenal overactivity (HP:0002717)	1.66412877
98	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.66073970
99	Foot dorsiflexor weakness (HP:0009027)	1.65087610
100	Hyperlipoproteinemia (HP:0010980)	1.64422362

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	3.51704683
2	MAPK15	3.46881828
3	RIPK1	3.11720345
4	MYLK	3.10603053
5	EPHB2	2.71115705
6	DDR2	2.68408252
7	DMPK	2.57977216
8	TAOK2	2.57764959
9	PDGFRA	2.25175809
10	LATS2	2.21062966
11	ERN1	2.11461089
12	EPHA3	2.11078511
13	EPHB1	1.66271802
14	CDC42BPA	1.64779762
15	TTN	1.64709855
16	TIE1	1.64100230
17	GRK1	1.63617956
18	TRIB3	1.50225702
19	ABL2	1.42729973
20	PDGFRB	1.40253828
21	TGFBR2	1.39641131
22	PAK2	1.38336024
23	MAPK7	1.34227945
24	PDK2	1.29821842
25	MAPK12	1.29158838
26	MAP3K3	1.20958921
27	IRAK1	1.19573272
28	PINK1	1.12264572
29	KIT	1.11548995
30	ROCK1	1.06565977
31	MAPK4	1.00217312
32	GSK3A	0.98170548
33	NLK	0.97394538
34	MAP3K1	0.94847904
35	RPS6KL1	0.94250180
36	RPS6KC1	0.94250180
37	MAP3K11	0.93419874
38	RPS6KA6	0.90054158
39	IRAK3	0.88869949
40	IRAK2	0.88616276
41	AKT3	0.85582055
42	RPS6KA2	0.84981868
43	NTRK3	0.84917973
44	TYRO3	0.81804033
45	PRKAA2	0.80203314
46	TAOK1	0.80059230
47	PTK2	0.79640285
48	HIPK2	0.78035842
49	ADRBK1	0.76161947
50	PRKD1	0.75341465
51	SIK1	0.75109668
52	AKT2	0.74921904
53	JAK1	0.73486452
54	PAK3	0.72257351
55	MOS	0.71896519
56	RET	0.70898532
57	MARK2	0.68582870
58	STK38	0.67677427
59	MTOR	0.66588102
60	ROCK2	0.66248608
61	SGK494	0.65942851
62	SGK223	0.65942851
63	PKN1	0.65799239
64	MAP2K2	0.64188794
65	FGFR4	0.63974633
66	DAPK3	0.60808580
67	TBK1	0.59794734
68	RPS6KA5	0.59552485
69	STK11	0.59401769
70	MAPKAPK3	0.57499426
71	PTK2B	0.57253972
72	PIM2	0.56805517
73	CAMK2G	0.56673733
74	NTRK1	0.56027246
75	SGK2	0.55660666
76	PDPK1	0.55566475
77	KSR2	0.54905015
78	PRKG2	0.53643608
79	CAMK1	0.51728456
80	OBSCN	0.51536898
81	CDK3	0.51019441
82	CAMK4	0.50999673
83	CLK1	0.49778097
84	MAPK3	0.47820064
85	PNCK	0.46226610
86	RPS6KA1	0.44831942
87	JAK2	0.44819095
88	ADRBK2	0.44737111
89	LATS1	0.44535394
90	IKBKE	0.43257756
91	MAP3K6	0.43256513
92	FGFR3	0.42448501
93	MAPK1	0.41463476
94	CHUK	0.40740470
95	ICK	0.40711402
96	ZAP70	0.40643005
97	MAP3K7	0.40492256
98	MAP2K1	0.40389506
99	CAMK2D	0.40091440
100	MARK1	0.39369660

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.77131830
2	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.37738105
3	Prion diseases_Homo sapiens_hsa05020	2.17885237
4	ECM-receptor interaction_Homo sapiens_hsa04512	2.08564720
5	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.78798716
6	Complement and coagulation cascades_Homo sapiens_hsa04610	1.75572344
7	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.70955539
8	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.66208680
9	Mineral absorption_Homo sapiens_hsa04978	1.64067725
10	Sulfur relay system_Homo sapiens_hsa04122	1.62390869
11	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.61383804
12	PPAR signaling pathway_Homo sapiens_hsa03320	1.60236329
13	Phototransduction_Homo sapiens_hsa04744	1.55300018
14	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.46073095
15	Malaria_Homo sapiens_hsa05144	1.45863220
16	Pertussis_Homo sapiens_hsa05133	1.44491602
17	Protein digestion and absorption_Homo sapiens_hsa04974	1.41867042
18	Focal adhesion_Homo sapiens_hsa04510	1.37619178
19	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.33230854
20	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.28695323
21	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.28147251
22	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	1.27915395
23	Bile secretion_Homo sapiens_hsa04976	1.27846012
24	Renin secretion_Homo sapiens_hsa04924	1.26911626
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.26750585
26	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.21698166
27	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.20381237
28	Notch signaling pathway_Homo sapiens_hsa04330	1.14484413
29	Amoebiasis_Homo sapiens_hsa05146	1.12991942
30	TNF signaling pathway_Homo sapiens_hsa04668	1.10452232
31	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.08675028
32	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.98367446
33	Cocaine addiction_Homo sapiens_hsa05030	0.97523661
34	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.91901805
35	Toxoplasmosis_Homo sapiens_hsa05145	0.90571557
36	cAMP signaling pathway_Homo sapiens_hsa04024	0.88580337
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87471137
38	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.85315159
39	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84577883
40	Gastric acid secretion_Homo sapiens_hsa04971	0.81256669
41	Glycerolipid metabolism_Homo sapiens_hsa00561	0.80421037
42	Osteoclast differentiation_Homo sapiens_hsa04380	0.79956070
43	GnRH signaling pathway_Homo sapiens_hsa04912	0.79647481
44	Histidine metabolism_Homo sapiens_hsa00340	0.78417025
45	Phenylalanine metabolism_Homo sapiens_hsa00360	0.78338095
46	Gap junction_Homo sapiens_hsa04540	0.78328051
47	African trypanosomiasis_Homo sapiens_hsa05143	0.74992611
48	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.74296779
49	Arginine biosynthesis_Homo sapiens_hsa00220	0.73666598
50	Circadian entrainment_Homo sapiens_hsa04713	0.73246619
51	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.73122021
52	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.70918744
53	Estrogen signaling pathway_Homo sapiens_hsa04915	0.70846097
54	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70238741
55	Salivary secretion_Homo sapiens_hsa04970	0.70168445
56	Calcium signaling pathway_Homo sapiens_hsa04020	0.68294044
57	Pancreatic secretion_Homo sapiens_hsa04972	0.68141138
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.67946620
59	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.66188582
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66088260
61	MAPK signaling pathway_Homo sapiens_hsa04010	0.65576833
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.65474823
63	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.65380952
64	ABC transporters_Homo sapiens_hsa02010	0.64265252
65	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62341124
66	Leishmaniasis_Homo sapiens_hsa05140	0.60066173
67	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.59836496
68	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.59074100
69	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58673334
70	Proteoglycans in cancer_Homo sapiens_hsa05205	0.58118393
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.56805249
72	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.56773204
73	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.56581824
74	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.56092354
75	Small cell lung cancer_Homo sapiens_hsa05222	0.54956375
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54183502
77	Morphine addiction_Homo sapiens_hsa05032	0.53276698
78	Nitrogen metabolism_Homo sapiens_hsa00910	0.52881172
79	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.52225853
80	Amphetamine addiction_Homo sapiens_hsa05031	0.51570432
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.50801422
82	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49202501
83	VEGF signaling pathway_Homo sapiens_hsa04370	0.49075650
84	Insulin resistance_Homo sapiens_hsa04931	0.49014685
85	GABAergic synapse_Homo sapiens_hsa04727	0.48721541
86	Type II diabetes mellitus_Homo sapiens_hsa04930	0.47653774
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.47572050
88	Linoleic acid metabolism_Homo sapiens_hsa00591	0.45720349
89	Insulin secretion_Homo sapiens_hsa04911	0.45701297
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44860239
91	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.44771300
92	Folate biosynthesis_Homo sapiens_hsa00790	0.44510975
93	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.42388522
94	Cholinergic synapse_Homo sapiens_hsa04725	0.42305500
95	Fatty acid degradation_Homo sapiens_hsa00071	0.42298868
96	Pathways in cancer_Homo sapiens_hsa05200	0.42222422
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.40840241
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40221603
99	Circadian rhythm_Homo sapiens_hsa04710	0.40215226
100	Tight junction_Homo sapiens_hsa04530	0.40128940

C11ORF96

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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