ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	axoneme assembly (GO:0035082)	9.86171522
2	left/right pattern formation (GO:0060972)	8.90683171
3	primary alcohol catabolic process (GO:0034310)	7.42318875
4	ventricular system development (GO:0021591)	7.36564405
5	regulation of cilium movement (GO:0003352)	7.31366213
6	left/right axis specification (GO:0070986)	6.65271084
7	intraciliary transport (GO:0042073)	6.56249252
8	vitamin transmembrane transport (GO:0035461)	6.51213002
9	ethanol metabolic process (GO:0006067)	6.34914911
10	microtubule bundle formation (GO:0001578)	6.05355651
11	cilium organization (GO:0044782)	6.05237581
12	cilium assembly (GO:0042384)	5.89085391
13	diterpenoid biosynthetic process (GO:0016102)	5.84812504
14	centriole assembly (GO:0098534)	5.53272519
15	pyrimidine-containing compound transmembrane transport (GO:0072531)	5.14803328
16	lung epithelium development (GO:0060428)	5.07836715
17	response to xenobiotic stimulus (GO:0009410)	5.02715984
18	tolerance induction (GO:0002507)	4.91398686
19	one-carbon compound transport (GO:0019755)	4.86226827
20	ethanol oxidation (GO:0006069)	4.79689976
21	sperm capacitation (GO:0048240)	4.77332681
22	protein localization to cilium (GO:0061512)	4.76910419
23	cellular component assembly involved in morphogenesis (GO:0010927)	4.69184905
24	microtubule-based movement (GO:0007018)	4.66929871
25	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.49917527
26	negative regulation of B cell mediated immunity (GO:0002713)	4.49917527
27	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	4.41484256
28	establishment of apical/basal cell polarity (GO:0035089)	4.39289687
29	cilium morphogenesis (GO:0060271)	4.36280750
30	negative regulation of T cell differentiation in thymus (GO:0033085)	4.35442523
31	nucleoside diphosphate phosphorylation (GO:0006165)	4.34489439
32	regulation of microtubule-based movement (GO:0060632)	4.31009268
33	glomerular epithelial cell development (GO:0072310)	4.24434795
34	regulation of interleukin-5 production (GO:0032674)	4.22871167
35	cell projection assembly (GO:0030031)	4.22199330
36	negative regulation of humoral immune response (GO:0002921)	4.19198664
37	terpenoid biosynthetic process (GO:0016114)	4.13490864
38	positive regulation of tolerance induction (GO:0002645)	4.10820837
39	regulation of germinal center formation (GO:0002634)	4.03071927
40	retinoic acid metabolic process (GO:0042573)	3.90852074
41	sperm motility (GO:0030317)	3.82532922
42	regulation of interleukin-13 production (GO:0032656)	3.81449089
43	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.78973362
44	establishment of monopolar cell polarity (GO:0061162)	3.78973362
45	negative regulation of inclusion body assembly (GO:0090084)	3.73061104
46	glutathione derivative metabolic process (GO:1901685)	3.65573593
47	glutathione derivative biosynthetic process (GO:1901687)	3.65573593
48	microtubule depolymerization (GO:0007019)	3.61953274
49	regulation of autophagic vacuole assembly (GO:2000785)	3.60279639
50	cytoplasmic microtubule organization (GO:0031122)	3.43101568
51	exogenous drug catabolic process (GO:0042738)	3.34264709
52	primary alcohol metabolic process (GO:0034308)	3.33536774
53	microtubule polymerization or depolymerization (GO:0031109)	3.25479324
54	oligosaccharide biosynthetic process (GO:0009312)	3.22365656
55	retinol metabolic process (GO:0042572)	3.15241445
56	lateral ventricle development (GO:0021670)	3.11074384
57	regulation of tolerance induction (GO:0002643)	3.04191096
58	regulation of vacuole organization (GO:0044088)	3.04050145
59	O-glycan processing (GO:0016266)	3.03422559
60	axonemal dynein complex assembly (GO:0070286)	22.2244476
61	determination of left/right symmetry (GO:0007368)	2.99193112
62	establishment of tissue polarity (GO:0007164)	2.95375080
63	establishment of planar polarity (GO:0001736)	2.95375080
64	androgen biosynthetic process (GO:0006702)	2.90415166
65	centriole replication (GO:0007099)	2.89735366
66	aldehyde catabolic process (GO:0046185)	2.88680970
67	positive regulation of smoothened signaling pathway (GO:0045880)	2.88614926
68	determination of bilateral symmetry (GO:0009855)	2.87396298
69	microtubule-based process (GO:0007017)	2.83773718
70	carnitine metabolic process (GO:0009437)	2.82161657
71	smoothened signaling pathway (GO:0007224)	2.81869457
72	specification of symmetry (GO:0009799)	2.81626584
73	hydrogen peroxide biosynthetic process (GO:0050665)	2.79002086
74	lateral sprouting from an epithelium (GO:0060601)	2.78574061
75	mitochondrion degradation (GO:0000422)	2.74482107
76	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.74090342
77	multicellular organismal water homeostasis (GO:0050891)	2.73523406
78	spermatid development (GO:0007286)	2.73219804
79	organelle assembly (GO:0070925)	2.66396222
80	regulation of microtubule depolymerization (GO:0031114)	2.59508022
81	drug catabolic process (GO:0042737)	2.59401584
82	organic cation transport (GO:0015695)	2.52426072
83	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.51182370
84	embryonic camera-type eye development (GO:0031076)	2.48685012
85	excretion (GO:0007588)	2.48586902
86	reactive oxygen species biosynthetic process (GO:1903409)	2.46976604
87	progesterone metabolic process (GO:0042448)	2.46614864
88	hydrogen peroxide catabolic process (GO:0042744)	2.43566662
89	apical protein localization (GO:0045176)	2.42493421
90	regulation of toll-like receptor 4 signaling pathway (GO:0034143)	2.42395033
91	carnitine transmembrane transport (GO:1902603)	2.41608998
92	glutathione metabolic process (GO:0006749)	2.40651593
93	hypotonic response (GO:0006971)	2.37100934
94	regulation of inclusion body assembly (GO:0090083)	2.35978890
95	single fertilization (GO:0007338)	2.35100567
96	cilium or flagellum-dependent cell motility (GO:0001539)	17.5976456
97	cilium movement (GO:0003341)	15.9941726
98	motile cilium assembly (GO:0044458)	15.7813057
99	epithelial cilium movement (GO:0003351)	14.4159538
100	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.0637611

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.65618842
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.67320454
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.37740921
4	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	3.25086222
5	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.04613403
6	DROSHA_22980978_ChIP-Seq_HELA_Human	3.00744324
7	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.84027536
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.67825975
9	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.13261059
10	AHR_22903824_ChIP-Seq_MCF-7_Human	2.06882641
11	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	2.05663117
12	SMC4_20622854_ChIP-Seq_HELA_Human	2.01851812
13	STAT1_20625510_ChIP-Seq_HELA_Human	1.96481986
14	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.86663253
15	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.78195526
16	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.77318705
17	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.76843115
18	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.66339448
19	VDR_22108803_ChIP-Seq_LS180_Human	1.65418252
20	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.63138459
21	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.60801262
22	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.60336492
23	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.59704645
24	TP63_23658742_ChIP-Seq_EP156T_Human	1.59410841
25	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.57448742
26	TP63_22573176_ChIP-Seq_HFKS_Human	1.50558564
27	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.49918674
28	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.46743805
29	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.46625337
30	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.43546792
31	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.41772301
32	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.38748856
33	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.38334565
34	CTCF_27219007_Chip-Seq_Bcells_Human	1.37430857
35	TP53_18474530_ChIP-ChIP_U2OS_Human	1.35494182
36	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.32396511
37	ETV1_20927104_ChIP-Seq_GIST48_Human	1.30179511
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29973882
39	KLF5_25053715_ChIP-Seq_YYC3_Human	1.29678743
40	PHF8_20622853_ChIP-Seq_HELA_Human	1.29333073
41	CTCF_20526341_ChIP-Seq_ESCs_Human	1.29162522
42	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.28436149
43	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.26244555
44	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.26098030
45	SOX2_20726797_ChIP-Seq_SW620_Human	1.26037388
46	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25297769
47	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.24934598
48	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.24743508
49	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.24418721
50	ZNF263_19887448_ChIP-Seq_K562_Human	1.23310963
51	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.22991296
52	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.21261281
53	P68_20966046_ChIP-Seq_HELA_Human	1.20598754
54	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.19010289
55	PHF8_20622854_ChIP-Seq_HELA_Human	1.18679748
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.17040329
57	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.17010574
58	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.16895442
59	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.15742693
60	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.13650258
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12279102
62	SMRT_27268052_Chip-Seq_Bcells_Human	1.12027332
63	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.11843853
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.10731801
65	RBPJ_21746931_ChIP-Seq_IB4_Human	1.08919599
66	GATA1_19941826_ChIP-Seq_K562_Human	1.08678665
67	TBL1_22424771_ChIP-Seq_293T_Human	1.05865270
68	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05117378
69	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.04563722
70	CREB1_26743006_Chip-Seq_LNCaP_Human	1.03998830
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.03669713
72	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.03584677
73	NFYA_21822215_ChIP-Seq_K562_Human	1.01996181
74	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.01763020
75	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.01465578
76	P300_27268052_Chip-Seq_Bcells_Human	1.01372459
77	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98761238
78	NFYB_21822215_ChIP-Seq_K562_Human	0.97986630
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96249866
80	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95838380
81	GATA4_25053715_ChIP-Seq_YYC3_Human	0.95717483
82	BCAT_22108803_ChIP-Seq_LS180_Human	0.95108184
83	CEBPB_22108803_ChIP-Seq_LS180_Human	0.94847253
84	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.94187527
85	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.93946922
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.93340118
87	E2F1_20622854_ChIP-Seq_HELA_Human	0.92382781
88	LXR_22292898_ChIP-Seq_THP-1_Human	0.92333275
89	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92217932
90	SOX2_21211035_ChIP-Seq_LN229_Human	0.91829477
91	STAT1_17558387_ChIP-Seq_HELA_Human	0.91450407
92	RACK7_27058665_Chip-Seq_MCF-7_Human	0.91006735
93	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.89319560
94	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.89020369
95	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.88169033
96	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.88154303
97	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.87210095
98	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.86674497
99	ER_23166858_ChIP-Seq_MCF-7_Human	0.85796827
100	ERG_20517297_ChIP-Seq_VCAP_Human	0.85175261

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	6.80174652
2	MP0002132_abnormal_respiratory_system	6.25634543
3	MP0002653_abnormal_ependyma_morphology	5.97972696
4	MP0001984_abnormal_olfaction	4.57899079
5	MP0002277_abnormal_respiratory_mucosa	3.69464159
6	MP0004043_abnormal_pH_regulation	3.50246064
7	MP0009780_abnormal_chondrocyte_physiolo	3.44797229
8	MP0008789_abnormal_olfactory_epithelium	3.35893765
9	MP0004133_heterotaxia	3.31037788
10	MP0005623_abnormal_meninges_morphology	3.22501691
11	MP0000566_synostosis	2.67155376
12	MP0005394_taste/olfaction_phenotype	2.66606387
13	MP0005499_abnormal_olfactory_system	2.66606387
14	MP0002160_abnormal_reproductive_system	2.64299787
15	MP0004019_abnormal_vitamin_homeostasis	2.11915761
16	MP0005377_hearing/vestibular/ear_phenot	2.11012314
17	MP0003878_abnormal_ear_physiology	2.11012314
18	MP0002282_abnormal_trachea_morphology	1.90503269
19	MP0002168_other_aberrant_phenotype	1.87875134
20	MP0010234_abnormal_vibrissa_follicle	1.85187965
21	MP0008004_abnormal_stomach_pH	1.78272143
22	MP0000383_abnormal_hair_follicle	1.68941285
23	MP0010678_abnormal_skin_adnexa	1.68302518
24	MP0003136_yellow_coat_color	1.63681080
25	MP0003656_abnormal_erythrocyte_physiolo	1.61828307
26	MP0001765_abnormal_ion_homeostasis	1.59320398
27	MP0000678_abnormal_parathyroid_gland	1.56914712
28	MP0005083_abnormal_biliary_tract	1.55272736
29	MP0002249_abnormal_larynx_morphology	1.39936789
30	MP0005248_abnormal_Harderian_gland	1.38920955
31	MP0000465_gastrointestinal_hemorrhage	1.36126264
32	MP0010030_abnormal_orbit_morphology	1.27955206
33	MP0001849_ear_inflammation	1.26271576
34	MP0002233_abnormal_nose_morphology	1.24937164
35	MP0003698_abnormal_male_reproductive	1.23639111
36	MP0005395_other_phenotype	1.22069143
37	MP0005389_reproductive_system_phenotype	1.21340409
38	MP0004264_abnormal_extraembryonic_tissu	1.20700798
39	MP0001346_abnormal_lacrimal_gland	1.19351422
40	MP0001929_abnormal_gametogenesis	1.18312251
41	MP0003806_abnormal_nucleotide_metabolis	1.15635355
42	MP0005165_increased_susceptibility_to	1.11852630
43	MP0002909_abnormal_adrenal_gland	1.10995278
44	MP0010155_abnormal_intestine_physiology	1.05043398
45	MP0005410_abnormal_fertilization	1.04312362
46	MP0000681_abnormal_thyroid_gland	1.03101340
47	MP0002734_abnormal_mechanical_nocicepti	1.01162034
48	MP0001664_abnormal_digestion	0.99728920
49	MP0005636_abnormal_mineral_homeostasis	0.99195163
50	MP0002876_abnormal_thyroid_physiology	0.98498114
51	MP0009046_muscle_twitch	0.92960503
52	MP0001188_hyperpigmentation	0.87391238
53	MP0002638_abnormal_pupillary_reflex	0.85508737
54	MP0001485_abnormal_pinna_reflex	0.83536339
55	MP0002139_abnormal_hepatobiliary_system	0.79537222
56	MP0005365_abnormal_bile_salt	0.79026650
57	MP0001270_distended_abdomen	0.78122636
58	MP0002735_abnormal_chemical_nociception	0.75134929
59	MP0005164_abnormal_response_to	0.74270560
60	MP0004883_abnormal_blood_vessel	0.72017629
61	MP0006036_abnormal_mitochondrial_physio	0.70100697
62	MP0009643_abnormal_urine_homeostasis	0.69744966
63	MP0010368_abnormal_lymphatic_system	0.66167312
64	MP0005409_darkened_coat_color	0.65872970
65	MP0005646_abnormal_pituitary_gland	0.65195361
66	MP0003045_fibrosis	0.65131779
67	MP0005220_abnormal_exocrine_pancreas	0.64661866
68	MP0005085_abnormal_gallbladder_physiolo	0.64477619
69	MP0003890_abnormal_embryonic-extraembry	0.63904268
70	MP0000026_abnormal_inner_ear	0.63259584
71	MP0001502_abnormal_circadian_rhythm	0.62806261
72	MP0002161_abnormal_fertility/fecundity	0.62258970
73	MP0002136_abnormal_kidney_physiology	0.61997449
74	MP0005253_abnormal_eye_physiology	0.61774264
75	MP0003453_abnormal_keratinocyte_physiol	0.61677280
76	MP0000467_abnormal_esophagus_morphology	0.57378531
77	MP0003938_abnormal_ear_development	0.54627674
78	MP0003879_abnormal_hair_cell	0.54298136
79	MP0009379_abnormal_foot_pigmentation	0.54181619
80	MP0003303_peritoneal_inflammation	0.53994798
81	MP0009765_abnormal_xenobiotic_induced	0.52403296
82	MP0003315_abnormal_perineum_morphology	0.50396660
83	MP0002405_respiratory_system_inflammati	0.50107647
84	MP0003075_altered_response_to	0.50101168
85	MP0005408_hypopigmentation	0.48319477
86	MP0001299_abnormal_eye_distance/	0.47952895
87	MP0002098_abnormal_vibrissa_morphology	0.47067431
88	MP0002116_abnormal_craniofacial_bone	0.45857671
89	MP0005166_decreased_susceptibility_to	0.45593861
90	MP0000049_abnormal_middle_ear	0.45379831
91	MP0004782_abnormal_surfactant_physiolog	0.43718510
92	MP0009703_decreased_birth_body	0.43301240
93	MP0002133_abnormal_respiratory_system	0.43035719
94	MP0005388_respiratory_system_phenotype	0.43035719
95	MP0001963_abnormal_hearing_physiology	0.43001626
96	MP0003866_abnormal_defecation	0.42416557
97	MP0009763_increased_sensitivity_to	0.41832299
98	MP0002229_neurodegeneration	0.41589446
99	MP0001324_abnormal_eye_pigmentation	0.41371544
100	MP0005310_abnormal_salivary_gland	0.39822320

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic bronchitis (HP:0004469)	7.94020382
2	Bronchiectasis (HP:0002110)	7.48773525
3	Nasal polyposis (HP:0100582)	6.92732215
4	Abnormality of the nasal mucosa (HP:0000433)	5.79937405
5	Infertility (HP:0000789)	4.50700707
6	Recurrent sinusitis (HP:0011108)	4.31096311
7	Chronic sinusitis (HP:0011109)	4.30205883
8	Bronchitis (HP:0012387)	4.27765935
9	Recurrent otitis media (HP:0000403)	3.81696832
10	Occipital encephalocele (HP:0002085)	3.80775466
11	Male infertility (HP:0003251)	3.77688720
12	True hermaphroditism (HP:0010459)	3.48587525
13	Pancreatic fibrosis (HP:0100732)	3.47392616
14	Chronic otitis media (HP:0000389)	3.09246171
15	Atelectasis (HP:0100750)	3.05611542
16	Cystic liver disease (HP:0006706)	2.94475865
17	Hyperactive renin-angiotensin system (HP:0000841)	2.85170015
18	Pancreatic cysts (HP:0001737)	2.83793042
19	Molar tooth sign on MRI (HP:0002419)	2.72883602
20	Abnormality of midbrain morphology (HP:0002418)	2.72883602
21	Nephronophthisis (HP:0000090)	2.58888909
22	Chronic hepatic failure (HP:0100626)	2.43949833
23	Postaxial foot polydactyly (HP:0001830)	2.36128978
24	Male pseudohermaphroditism (HP:0000037)	2.21588041
25	Tubulointerstitial nephritis (HP:0001970)	2.15317278
26	Anencephaly (HP:0002323)	2.07629777
27	Congenital hepatic fibrosis (HP:0002612)	2.03344324
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.5949545
29	Abnormal respiratory motile cilium physiology (HP:0012261)	11.2663937
30	Abnormal respiratory motile cilium morphology (HP:0005938)	11.2655608
31	Abnormal respiratory epithelium morphology (HP:0012253)	11.2655608
32	Abnormal ciliary motility (HP:0012262)	10.9716405
33	Absent/shortened dynein arms (HP:0200106)	10.7930156
34	Dynein arm defect of respiratory motile cilia (HP:0012255)	10.7930156
35	Rhinitis (HP:0012384)	10.2671486
36	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98544197
37	Abnormality of the renal medulla (HP:0100957)	1.97904292
38	Bell-shaped thorax (HP:0001591)	1.92874281
39	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.84885838
40	Medial flaring of the eyebrow (HP:0010747)	1.76832036
41	Recurrent bronchitis (HP:0002837)	1.75966003
42	Absent frontal sinuses (HP:0002688)	1.75415912
43	Decreased circulating renin level (HP:0003351)	1.73845301
44	Renal salt wasting (HP:0000127)	1.72022285
45	Furrowed tongue (HP:0000221)	1.69766728
46	Sclerocornea (HP:0000647)	1.67349592
47	Congenital primary aphakia (HP:0007707)	1.63635825
48	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.60963087
49	Gait imbalance (HP:0002141)	1.60906717
50	Asplenia (HP:0001746)	1.60892680
51	Oculomotor apraxia (HP:0000657)	1.60162609
52	Nephropathy (HP:0000112)	1.59255482
53	Tubular atrophy (HP:0000092)	1.56103657
54	Postaxial hand polydactyly (HP:0001162)	1.54521279
55	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.47693976
56	Abnormality of the frontal sinuses (HP:0002687)	1.46918995
57	Median cleft lip (HP:0000161)	1.44271568
58	Hyperkalemia (HP:0002153)	1.43823264
59	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.42452251
60	Hyperaldosteronism (HP:0000859)	1.42320245
61	Nephrogenic diabetes insipidus (HP:0009806)	1.41632301
62	Abnormality of the dental root (HP:0006486)	1.36414873
63	Taurodontia (HP:0000679)	1.36414873
64	Abnormality of permanent molar morphology (HP:0011071)	1.36414873
65	Bifid scrotum (HP:0000048)	1.32143183
66	Preaxial hand polydactyly (HP:0001177)	1.27781654
67	Abnormality of renin-angiotensin system (HP:0000847)	1.27732267
68	Short nail (HP:0001799)	1.26626641
69	Abnormality of molar (HP:0011077)	1.25697484
70	Abnormality of molar morphology (HP:0011070)	1.25697484
71	Self-mutilation (HP:0000742)	1.25160159
72	Abnormality of chloride homeostasis (HP:0011422)	1.21729603
73	Tubulointerstitial abnormality (HP:0001969)	1.20411218
74	Abnormality of the dental pulp (HP:0006479)	1.20385189
75	Hypokalemic alkalosis (HP:0001949)	1.18152403
76	Hand muscle atrophy (HP:0009130)	1.17991301
77	Short thorax (HP:0010306)	1.16200027
78	Poor coordination (HP:0002370)	1.14583268
79	Stage 5 chronic kidney disease (HP:0003774)	1.12388399
80	Abnormality of the distal phalanges of the toes (HP:0010182)	1.12367123
81	Abnormality of dentin (HP:0010299)	1.09759882
82	Bile duct proliferation (HP:0001408)	1.09441777
83	Abnormal biliary tract physiology (HP:0012439)	1.09441777
84	Decreased central vision (HP:0007663)	1.08856234
85	Popliteal pterygium (HP:0009756)	1.08806492
86	Ventricular fibrillation (HP:0001663)	1.08757054
87	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.08171211
88	Vaginal atresia (HP:0000148)	1.07910898
89	Genital tract atresia (HP:0001827)	1.07160867
90	Fetal akinesia sequence (HP:0001989)	1.05995870
91	Hyponatremia (HP:0002902)	1.05858110
92	Glucose intolerance (HP:0000833)	1.05325923
93	Polydipsia (HP:0001959)	1.03719085
94	Abnormal drinking behavior (HP:0030082)	1.03719085
95	Absent speech (HP:0001344)	1.02595819
96	Abnormality of macular pigmentation (HP:0008002)	1.01779812
97	Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)	1.01055309
98	Cone-rod dystrophy (HP:0000548)	0.98659806
99	Nonprogressive disorder (HP:0003680)	0.97209074
100	Muscle fiber splitting (HP:0003555)	0.96007457

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	4.96202599
2	EPHA2	4.44104461
3	PINK1	2.95250389
4	MAPKAPK3	2.38565726
5	SMG1	2.25460915
6	MAP3K2	2.25282766
7	LATS1	2.04182576
8	MAPK15	11.5602389
9	EEF2K	1.93609740
10	TLK1	1.91694159
11	NME1	1.84414372
12	PTK2B	1.72651911
13	STK24	1.65788106
14	MYLK	1.57500460
15	TTK	1.57131491
16	MAP3K3	1.53615499
17	STK38L	1.39276976
18	MARK3	1.35696570
19	STK38	1.31550905
20	CSK	1.29828763
21	BCR	1.23210182
22	MST1R	1.11300182
23	EPHB1	1.06717919
24	NEK6	1.06106855
25	LRRK2	0.94513216
26	PNCK	0.91954569
27	TRPM7	0.91006672
28	MARK2	0.83502185
29	STK10	0.79757298
30	LATS2	0.78038007
31	NEK2	0.76563265
32	PRKCQ	0.75373521
33	MAP3K7	0.72430608
34	RIPK4	0.70994346
35	MAP2K7	0.68273656
36	PRKCI	0.68265210
37	ICK	0.63707641
38	TBK1	0.63353889
39	CCNB1	0.61404086
40	MAP3K12	0.59351946
41	GRK6	0.57128638
42	CAMKK1	0.55607396
43	CDC42BPA	0.54738221
44	PDPK1	0.51522521
45	AURKA	0.50588338
46	RPS6KA5	0.45873084
47	ARAF	0.45589560
48	TRIB3	0.45307321
49	SGK223	0.45010029
50	SGK494	0.45010029
51	CAMK2G	0.42962709
52	TESK1	0.41194224
53	PAK1	0.40919497
54	EPHA3	0.40757595
55	CDK3	0.40333789
56	ERBB2	0.39808117
57	PBK	0.39652192
58	AKT2	0.38723771
59	PRKCD	0.38649648
60	NLK	0.37400982
61	SGK1	0.34413426
62	MELK	0.32754970
63	ERBB3	0.32518938
64	HIPK2	0.31101170
65	GRK1	0.30455663
66	EGFR	0.29871990
67	STK16	0.29865250
68	TAOK1	0.29668059
69	RET	0.28672326
70	MAPKAPK5	0.28052914
71	PRKAA2	0.27703772
72	ILK	0.26568349
73	OBSCN	0.25844523
74	RPS6KB1	0.25488731
75	ROCK1	0.25444425
76	MAP3K5	0.24288280
77	PLK1	0.23873930
78	DYRK1B	0.22379337
79	BRSK2	0.21829756
80	RPS6KB2	0.21616698
81	MUSK	0.18041557
82	RIPK1	0.17968278
83	PRKD3	0.17168498
84	FGFR3	0.16663795
85	PRKACA	0.16497616
86	MAP3K1	0.15318692
87	PRKCA	0.14460175
88	DYRK3	0.13723746
89	PDK1	0.13612732
90	MAP3K4	0.11818960
91	MAP2K4	0.11582922
92	RPS6KA2	0.11418734
93	ABL1	0.11117236
94	ROCK2	0.10752666
95	CDK19	0.10275916
96	PRKG1	0.10060140
97	ADRBK1	0.09898092
98	MAP3K13	0.09873400
99	STK3	0.09493838
100	MAP4K2	0.08577075

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.72906218
2	Phenylalanine metabolism_Homo sapiens_hsa00360	5.05160278
3	Chemical carcinogenesis_Homo sapiens_hsa05204	4.73665522
4	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.48545082
5	Histidine metabolism_Homo sapiens_hsa00340	4.35848204
6	Tyrosine metabolism_Homo sapiens_hsa00350	3.86468819
7	beta-Alanine metabolism_Homo sapiens_hsa00410	3.08773605
8	Glutathione metabolism_Homo sapiens_hsa00480	2.88326101
9	Huntingtons disease_Homo sapiens_hsa05016	2.33058734
10	Retinol metabolism_Homo sapiens_hsa00830	2.30501599
11	Caffeine metabolism_Homo sapiens_hsa00232	2.05652465
12	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	2.03606748
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.89030838
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.85382862
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.68696943
16	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.65578602
17	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.58658467
18	Sphingolipid metabolism_Homo sapiens_hsa00600	1.57765749
19	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.55074404
20	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.53574131
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45797937
22	Fatty acid degradation_Homo sapiens_hsa00071	1.31345329
23	Tight junction_Homo sapiens_hsa04530	1.25760098
24	Olfactory transduction_Homo sapiens_hsa04740	1.13828457
25	Peroxisome_Homo sapiens_hsa04146	1.10670942
26	ABC transporters_Homo sapiens_hsa02010	1.10230245
27	Salivary secretion_Homo sapiens_hsa04970	1.09057522
28	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00381124
29	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91378728
30	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.89592766
31	Circadian rhythm_Homo sapiens_hsa04710	0.89332763
32	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.86701496
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86378401
34	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85422244
35	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.82211994
36	Gap junction_Homo sapiens_hsa04540	0.80637622
37	Taste transduction_Homo sapiens_hsa04742	0.68379389
38	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.66946423
39	Arginine biosynthesis_Homo sapiens_hsa00220	0.60907038
40	Phagosome_Homo sapiens_hsa04145	0.59902602
41	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58956664
42	Choline metabolism in cancer_Homo sapiens_hsa05231	0.58768523
43	Nitrogen metabolism_Homo sapiens_hsa00910	0.55628647
44	PPAR signaling pathway_Homo sapiens_hsa03320	0.55520183
45	Butanoate metabolism_Homo sapiens_hsa00650	0.54671700
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54663978
47	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50561839
48	Hepatitis C_Homo sapiens_hsa05160	0.49763918
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.48924415
50	Complement and coagulation cascades_Homo sapiens_hsa04610	0.48218286
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.47471930
52	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.46591122
53	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.46251682
54	Apoptosis_Homo sapiens_hsa04210	0.40633417
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40460345
56	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.39798601
57	Arginine and proline metabolism_Homo sapiens_hsa00330	0.39699741
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.39515995
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38696887
60	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.38565299
61	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36313578
62	Metabolic pathways_Homo sapiens_hsa01100	0.34989963
63	Notch signaling pathway_Homo sapiens_hsa04330	0.33107936
64	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.33075608
65	Cocaine addiction_Homo sapiens_hsa05030	0.31664763
66	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.31452158
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.30667316
68	Phototransduction_Homo sapiens_hsa04744	0.30372637
69	Nicotine addiction_Homo sapiens_hsa05033	0.28680150
70	Alcoholism_Homo sapiens_hsa05034	0.28249942
71	Calcium signaling pathway_Homo sapiens_hsa04020	0.28223281
72	cAMP signaling pathway_Homo sapiens_hsa04024	0.27359079
73	Adherens junction_Homo sapiens_hsa04520	0.26389677
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.25312884
75	Bile secretion_Homo sapiens_hsa04976	0.20581491
76	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.20507595
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.17743559
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.17579394
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.17387199
80	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.17314475
81	Gastric acid secretion_Homo sapiens_hsa04971	0.16964376
82	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.16478154
83	Amphetamine addiction_Homo sapiens_hsa05031	0.16033727
84	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.15653817
85	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.15561891
86	Pancreatic secretion_Homo sapiens_hsa04972	0.15302706
87	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.14397912
88	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.14258985
89	Regulation of autophagy_Homo sapiens_hsa04140	0.13931284
90	Lysosome_Homo sapiens_hsa04142	0.11910291
91	Amoebiasis_Homo sapiens_hsa05146	0.11724882
92	Prostate cancer_Homo sapiens_hsa05215	0.11466686
93	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.10442235
94	Serotonergic synapse_Homo sapiens_hsa04726	0.10257516
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.10009227
96	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.09709016
97	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.08493387
98	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.08122425
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.07929309
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.07642071

C11ORF97

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »