C11ORF98

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.36860764
2ATP synthesis coupled proton transport (GO:0015986)6.37368707
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.37368707
4chaperone-mediated protein transport (GO:0072321)6.21014066
5establishment of protein localization to mitochondrial membrane (GO:0090151)6.15309240
6ribosomal small subunit assembly (GO:0000028)5.77541249
7viral transcription (GO:0019083)5.50679463
8ribosomal small subunit biogenesis (GO:0042274)5.43122241
9translational termination (GO:0006415)5.36664096
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.32103820
11proteasome assembly (GO:0043248)5.30464345
12respiratory electron transport chain (GO:0022904)5.24720845
13maturation of SSU-rRNA (GO:0030490)5.24130626
14electron transport chain (GO:0022900)5.14248057
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.06840106
16cotranslational protein targeting to membrane (GO:0006613)5.01143283
17protein targeting to ER (GO:0045047)4.98550531
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.79792593
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.76177951
20protein localization to endoplasmic reticulum (GO:0070972)4.70332762
21translational elongation (GO:0006414)4.65970351
22termination of RNA polymerase III transcription (GO:0006386)4.64928931
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.64928931
24protein complex biogenesis (GO:0070271)4.52573369
25regulation of mitochondrial translation (GO:0070129)4.48334348
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.40786247
27negative regulation of ligase activity (GO:0051352)4.40786247
28ribosomal large subunit biogenesis (GO:0042273)4.39554504
29establishment of integrated proviral latency (GO:0075713)4.38003238
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.34991843
31mitochondrial respiratory chain complex assembly (GO:0033108)4.33290509
32positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.33027602
33translational initiation (GO:0006413)4.30589836
34translation (GO:0006412)4.29597707
35rRNA modification (GO:0000154)4.23925646
36viral life cycle (GO:0019058)4.23337170
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.23027597
38mitochondrial respiratory chain complex I assembly (GO:0032981)4.18587158
39NADH dehydrogenase complex assembly (GO:0010257)4.18587158
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.18587158
41regulation of cellular amino acid metabolic process (GO:0006521)4.18319076
42cellular protein complex disassembly (GO:0043624)4.15203274
43protein neddylation (GO:0045116)4.12280358
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.11751763
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.02616870
46respiratory chain complex IV assembly (GO:0008535)3.96541008
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.94767713
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.94689972
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.94689972
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.94689972
51intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.94001331
52signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.94001331
53exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.93219323
54protein targeting to mitochondrion (GO:0006626)3.92430690
55signal transduction involved in DNA integrity checkpoint (GO:0072401)3.82369101
56signal transduction involved in DNA damage checkpoint (GO:0072422)3.82369101
57pseudouridine synthesis (GO:0001522)3.78410095
58signal transduction involved in cell cycle checkpoint (GO:0072395)3.77329904
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.75908282
60establishment of viral latency (GO:0019043)3.74443645
61cytochrome complex assembly (GO:0017004)3.74200946
62establishment of protein localization to mitochondrion (GO:0072655)3.74092509
63spliceosomal snRNP assembly (GO:0000387)3.71559143
64cellular component biogenesis (GO:0044085)3.70950523
65chromatin remodeling at centromere (GO:0031055)3.70846124
66ribonucleoprotein complex biogenesis (GO:0022613)3.69224200
67rRNA processing (GO:0006364)3.64836698
68protein localization to mitochondrion (GO:0070585)3.63961903
69CENP-A containing nucleosome assembly (GO:0034080)3.62864740
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61989690
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61989690
72DNA deamination (GO:0045006)3.61360989
73positive regulation of ligase activity (GO:0051351)3.58661334
74protein complex disassembly (GO:0043241)3.56860947
75inner mitochondrial membrane organization (GO:0007007)3.54150457
76rRNA metabolic process (GO:0016072)3.50029470
77ATP biosynthetic process (GO:0006754)3.48186476
78macromolecular complex disassembly (GO:0032984)3.41376467
79regulation of ubiquitin-protein transferase activity (GO:0051438)3.41371851
80hydrogen ion transmembrane transport (GO:1902600)3.40831090
81oxidative phosphorylation (GO:0006119)3.35357109
82nuclear-transcribed mRNA catabolic process (GO:0000956)3.34951354
83protein targeting to membrane (GO:0006612)3.31983305
84purine nucleoside triphosphate biosynthetic process (GO:0009145)3.31456649
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30716352
86rRNA methylation (GO:0031167)3.28819792
87regulation of ligase activity (GO:0051340)3.28317738
88antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.25139769
89telomere maintenance via semi-conservative replication (GO:0032201)3.22406215
90protein-cofactor linkage (GO:0018065)3.22388900
917-methylguanosine mRNA capping (GO:0006370)3.22332720
92DNA strand elongation involved in DNA replication (GO:0006271)3.17617662
93mRNA catabolic process (GO:0006402)3.15752378
94nucleobase biosynthetic process (GO:0046112)3.15710864
95purine nucleobase biosynthetic process (GO:0009113)3.15214071
96regulation of cellular amine metabolic process (GO:0033238)3.14733322
97RNA capping (GO:0036260)3.13938936
987-methylguanosine RNA capping (GO:0009452)3.13938936
99DNA damage response, detection of DNA damage (GO:0042769)3.13782409
100mitochondrial transport (GO:0006839)3.13472561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.37294147
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.79483636
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.43252274
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.19764616
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.97573162
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.71854838
7E2F7_22180533_ChIP-Seq_HELA_Human3.70028502
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.61620684
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.60707024
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40133016
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31372138
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.26236465
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16095366
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.07276162
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.01663830
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.98995158
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89702301
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82177727
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80127009
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62506952
21VDR_23849224_ChIP-Seq_CD4+_Human2.55431250
22ELK1_19687146_ChIP-ChIP_HELA_Human2.51523827
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.50706506
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49218307
25FOXP3_21729870_ChIP-Seq_TREG_Human2.48684954
26XRN2_22483619_ChIP-Seq_HELA_Human2.44004798
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25413867
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.25308442
29DCP1A_22483619_ChIP-Seq_HELA_Human2.20920167
30TTF2_22483619_ChIP-Seq_HELA_Human2.20794514
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20156898
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.15997657
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.14388554
34GABP_19822575_ChIP-Seq_HepG2_Human2.12192200
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08074582
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86889254
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80269725
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68042247
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67639737
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.66035323
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61676468
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.59302830
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58822359
44MYC_18940864_ChIP-ChIP_HL60_Human1.56450346
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55511148
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52264391
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51157151
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51075199
49CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49159229
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46050837
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41236622
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36294734
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.33908104
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32780791
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28143012
56KDM5A_27292631_Chip-Seq_BREAST_Human1.27378433
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26968663
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.26396154
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25062087
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21369393
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.21158442
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17979519
63AR_21909140_ChIP-Seq_LNCAP_Human1.16516280
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.16027404
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11828042
66BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10825327
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10426966
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.07872162
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04061553
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03612120
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02654982
72SOX2_16153702_ChIP-ChIP_HESCs_Human1.01724459
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.01471055
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01085591
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98382711
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96986384
77CTCF_18555785_ChIP-Seq_MESCs_Mouse0.96425220
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91980949
79FOXP1_21924763_ChIP-Seq_HESCs_Human0.88695349
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88591273
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88443240
82CIITA_25753668_ChIP-Seq_RAJI_Human0.84727611
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83407586
84SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80673500
85VDR_22108803_ChIP-Seq_LS180_Human0.80587336
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80352202
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79782070
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76454155
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.76409864
90OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75861497
91ELF5_23300383_ChIP-Seq_T47D_Human0.74866888
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.74581734
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74375784
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73329368
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.72168334
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.70386639
97TP53_22573176_ChIP-Seq_HFKS_Human0.70200276
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.69602697
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.67992009
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67609170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.39056502
2MP0003693_abnormal_embryo_hatching4.05413163
3MP0004957_abnormal_blastocyst_morpholog3.76563572
4MP0008058_abnormal_DNA_repair3.64619410
5MP0006292_abnormal_olfactory_placode3.46165327
6MP0010094_abnormal_chromosome_stability3.14152172
7MP0003718_maternal_effect2.79681429
8MP0003806_abnormal_nucleotide_metabolis2.73779755
9MP0003186_abnormal_redox_activity2.73493846
10MP0003111_abnormal_nucleus_morphology2.68288538
11MP0003077_abnormal_cell_cycle2.44452692
12MP0008932_abnormal_embryonic_tissue2.39081531
13MP0006036_abnormal_mitochondrial_physio2.21136775
14MP0008789_abnormal_olfactory_epithelium2.20838653
15MP0006035_abnormal_mitochondrial_morpho2.17482085
16MP0003786_premature_aging2.17285745
17MP0000372_irregular_coat_pigmentation2.11288342
18MP0001529_abnormal_vocalization2.05264783
19MP0003136_yellow_coat_color2.03800541
20MP0001293_anophthalmia1.97503302
21MP0008007_abnormal_cellular_replicative1.91753923
22MP0003011_delayed_dark_adaptation1.78219976
23MP0002938_white_spotting1.77856403
24MP0002277_abnormal_respiratory_mucosa1.75780718
25MP0008877_abnormal_DNA_methylation1.72907593
26MP0003941_abnormal_skin_development1.71391577
27MP0010030_abnormal_orbit_morphology1.69944007
28MP0005499_abnormal_olfactory_system1.58106470
29MP0005394_taste/olfaction_phenotype1.58106470
30MP0006072_abnormal_retinal_apoptosis1.55471533
31MP0002163_abnormal_gland_morphology1.54477909
32MP0005084_abnormal_gallbladder_morpholo1.53832235
33MP0002736_abnormal_nociception_after1.53358593
34MP0005408_hypopigmentation1.51723039
35MP0003123_paternal_imprinting1.51664585
36MP0001905_abnormal_dopamine_level1.30012426
37MP0008995_early_reproductive_senescence1.27280931
38MP0003315_abnormal_perineum_morphology1.25773593
39MP0002837_dystrophic_cardiac_calcinosis1.19110837
40MP0009697_abnormal_copulation1.18747721
41MP0002210_abnormal_sex_determination1.18675880
42MP0005075_abnormal_melanosome_morpholog1.18271613
43MP0001485_abnormal_pinna_reflex1.18259255
44MP0002653_abnormal_ependyma_morphology1.17518757
45MP0004147_increased_porphyrin_level1.16557986
46MP0004142_abnormal_muscle_tone1.15607973
47MP0002132_abnormal_respiratory_system1.14947275
48MP0008057_abnormal_DNA_replication1.14303453
49MP0003567_abnormal_fetal_cardiomyocyte1.12924131
50MP0000358_abnormal_cell_content/1.10814406
51MP0004133_heterotaxia1.09366241
52MP0005377_hearing/vestibular/ear_phenot1.04388405
53MP0003878_abnormal_ear_physiology1.04388405
54MP0009333_abnormal_splenocyte_physiolog1.03376347
55MP0002102_abnormal_ear_morphology1.03348789
56MP0005379_endocrine/exocrine_gland_phen1.02343189
57MP0003121_genomic_imprinting1.02246532
58MP0000350_abnormal_cell_proliferation1.02243060
59MP0001919_abnormal_reproductive_system1.02177970
60MP0008872_abnormal_physiological_respon1.02149787
61MP0002095_abnormal_skin_pigmentation1.01797102
62MP0005174_abnormal_tail_pigmentation1.00001142
63MP0000313_abnormal_cell_death0.98934438
64MP0003938_abnormal_ear_development0.96527284
65MP0001929_abnormal_gametogenesis0.95302049
66MP0001188_hyperpigmentation0.92814867
67MP0002751_abnormal_autonomic_nervous0.91298288
68MP0005389_reproductive_system_phenotype0.90402481
69MP0001145_abnormal_male_reproductive0.90249979
70MP0001697_abnormal_embryo_size0.88945642
71MP0001730_embryonic_growth_arrest0.88044304
72MP0000653_abnormal_sex_gland0.87410999
73MP0000490_abnormal_crypts_of0.87268394
74MP0000049_abnormal_middle_ear0.86950314
75MP0002160_abnormal_reproductive_system0.86154876
76MP0001764_abnormal_homeostasis0.84211303
77MP0001968_abnormal_touch/_nociception0.81526255
78MP0003890_abnormal_embryonic-extraembry0.81307960
79MP0002638_abnormal_pupillary_reflex0.81165100
80MP0001881_abnormal_mammary_gland0.80905245
81MP0003119_abnormal_digestive_system0.80548096
82MP0005551_abnormal_eye_electrophysiolog0.79658454
83MP0001984_abnormal_olfaction0.79336607
84MP0001727_abnormal_embryo_implantation0.78608451
85MP0002085_abnormal_embryonic_tissue0.77570600
86MP0001286_abnormal_eye_development0.75607828
87MP0001119_abnormal_female_reproductive0.74818511
88MP0003937_abnormal_limbs/digits/tail_de0.73860131
89MP0000631_abnormal_neuroendocrine_gland0.73572771
90MP0002254_reproductive_system_inflammat0.72468625
91MP0005671_abnormal_response_to0.72006411
92MP0002080_prenatal_lethality0.71747228
93MP0008875_abnormal_xenobiotic_pharmacok0.70940198
94MP0002019_abnormal_tumor_incidence0.68060570
95MP0005253_abnormal_eye_physiology0.66955475
96MP0002233_abnormal_nose_morphology0.66564900
97MP0005636_abnormal_mineral_homeostasis0.66318312
98MP0005645_abnormal_hypothalamus_physiol0.63757634
99MP0002111_abnormal_tail_morphology0.63307791
100MP0000647_abnormal_sebaceous_gland0.63186387

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.17466072
2Abnormal mitochondria in muscle tissue (HP:0008316)5.60175529
3Mitochondrial inheritance (HP:0001427)5.49761651
4Increased hepatocellular lipid droplets (HP:0006565)5.42663615
5Acute encephalopathy (HP:0006846)5.40721300
6Progressive macrocephaly (HP:0004481)5.00748741
7Lipid accumulation in hepatocytes (HP:0006561)4.99465212
8Increased CSF lactate (HP:0002490)4.95914421
9Hepatocellular necrosis (HP:0001404)4.67239298
10Renal Fanconi syndrome (HP:0001994)4.36335515
11Abnormality of cells of the erythroid lineage (HP:0012130)4.28161543
12Reticulocytopenia (HP:0001896)4.23880294
13Abnormal number of erythroid precursors (HP:0012131)4.20995072
14Hepatic necrosis (HP:0002605)4.14896110
15Cerebral edema (HP:0002181)3.98634349
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.91348720
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.91348720
18Macrocytic anemia (HP:0001972)3.86030817
19Increased intramyocellular lipid droplets (HP:0012240)3.72799129
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.63505798
21Aplastic anemia (HP:0001915)3.46339904
22Exertional dyspnea (HP:0002875)3.40563187
233-Methylglutaconic aciduria (HP:0003535)3.30867786
24Increased serum lactate (HP:0002151)3.28563746
25Lactic acidosis (HP:0003128)3.24224171
26Increased muscle lipid content (HP:0009058)3.14556970
27Respiratory failure (HP:0002878)3.11284917
28Respiratory difficulties (HP:0002880)3.10321764
29Exercise intolerance (HP:0003546)3.00633648
30Oral leukoplakia (HP:0002745)2.99626414
31Colon cancer (HP:0003003)2.92466539
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89815353
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.89056778
34Leukodystrophy (HP:0002415)2.88260154
35Optic disc pallor (HP:0000543)2.78933885
36Pallor (HP:0000980)2.73314181
37Abnormality of renal resorption (HP:0011038)2.61813442
38Lethargy (HP:0001254)2.58868866
39Type I transferrin isoform profile (HP:0003642)2.57361847
40Septo-optic dysplasia (HP:0100842)2.55054405
41Microvesicular hepatic steatosis (HP:0001414)2.42442958
42Pancytopenia (HP:0001876)2.35294282
43Absent thumb (HP:0009777)2.31393838
44Methylmalonic aciduria (HP:0012120)2.31196254
45Hyperphosphaturia (HP:0003109)2.23298269
46Congenital, generalized hypertrichosis (HP:0004540)2.20600955
47Methylmalonic acidemia (HP:0002912)2.20599397
48Sparse eyelashes (HP:0000653)2.19621320
49Abnormality of the labia minora (HP:0012880)2.19025879
50Glycosuria (HP:0003076)2.18713595
51Abnormality of urine glucose concentration (HP:0011016)2.18713595
52Meckel diverticulum (HP:0002245)2.15058978
53Rough bone trabeculation (HP:0100670)2.11965535
54Hyperglycinemia (HP:0002154)2.11341143
55Increased serum pyruvate (HP:0003542)2.07914516
56CNS demyelination (HP:0007305)2.05999926
57Multiple enchondromatosis (HP:0005701)2.03211046
58Reduced antithrombin III activity (HP:0001976)2.02208428
59Abnormality of the anterior horn cell (HP:0006802)2.02154150
60Degeneration of anterior horn cells (HP:0002398)2.02154150
61Cellular immunodeficiency (HP:0005374)2.00436629
62X-linked dominant inheritance (HP:0001423)1.99823904
63Abnormality of the ileum (HP:0001549)1.99823317
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99010891
65Abnormal protein N-linked glycosylation (HP:0012347)1.99010891
66Abnormal protein glycosylation (HP:0012346)1.99010891
67Abnormal glycosylation (HP:0012345)1.99010891
68Absent septum pellucidum (HP:0001331)1.97911821
69Hypoplasia of the pons (HP:0012110)1.95564366
70Abnormality of methionine metabolism (HP:0010901)1.93346781
71Abnormality of placental membranes (HP:0011409)1.91781631
72Amniotic constriction ring (HP:0009775)1.91781631
73Abnormality of the pons (HP:0007361)1.90766437
74Horseshoe kidney (HP:0000085)1.89673037
75Abnormality of serum amino acid levels (HP:0003112)1.89297890
76Pancreatic cysts (HP:0001737)1.88214526
77Generalized aminoaciduria (HP:0002909)1.86429881
78Pancreatic fibrosis (HP:0100732)1.86322281
79Abnormality of the preputium (HP:0100587)1.85785944
80Cerebral hypomyelination (HP:0006808)1.84317678
81Megaloblastic anemia (HP:0001889)1.83732839
82Abnormality of glycolysis (HP:0004366)1.82513779
83Cleft eyelid (HP:0000625)1.80662364
84Sclerocornea (HP:0000647)1.76036801
85Emotional lability (HP:0000712)1.75610656
86Abnormality of the septum pellucidum (HP:0007375)1.75377084
87Blindness (HP:0000618)1.73775270
88Molar tooth sign on MRI (HP:0002419)1.73347759
89Abnormality of midbrain morphology (HP:0002418)1.73347759
90Testicular atrophy (HP:0000029)1.72974365
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.72839438
92Abnormal lung lobation (HP:0002101)1.72411698
93Triphalangeal thumb (HP:0001199)1.70730684
94Birth length less than 3rd percentile (HP:0003561)1.70533204
95Abnormality of aspartate family amino acid metabolism (HP:0010899)1.70287843
96True hermaphroditism (HP:0010459)1.68495417
97Abnormal urine phosphate concentration (HP:0012599)1.66621145
98Pendular nystagmus (HP:0012043)1.65070610
99Abnormal trabecular bone morphology (HP:0100671)1.64015514
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63901333

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.10327480
2BUB14.45592057
3NME23.20548093
4STK163.12235664
5CDC72.90696724
6PBK2.76928603
7MST42.76089480
8SRPK12.71155437
9NME12.68735837
10VRK12.58331073
11TESK22.22747590
12EIF2AK12.20853356
13ZAK2.19203540
14NEK12.12001292
15MAP3K122.09987442
16TSSK61.95986829
17PLK31.79481966
18TTK1.71085504
19KDR1.67979025
20NUAK11.67603918
21DYRK21.58331233
22WEE11.53457917
23PLK41.51403289
24BCKDK1.45831398
25EIF2AK31.38932779
26PLK11.34230791
27LIMK11.31410538
28TAF11.29718394
29WNK31.28099770
30TESK11.27754697
31TRIM281.21463221
32TLK11.15163342
33BRSK21.10180676
34AURKB1.04720814
35CHEK21.00116682
36TNIK0.99593382
37MKNK10.98523496
38MKNK20.97575017
39DYRK30.96357389
40PAK40.92613262
41ILK0.92062358
42BRSK10.89770614
43WNK40.87115731
44PDK20.86185564
45PASK0.84819415
46ATR0.84522006
47CSNK2A20.83990509
48AURKA0.83920773
49CSNK2A10.77279734
50LRRK20.76055161
51PRKCI0.73974580
52ADRBK20.72788048
53DAPK10.71548791
54BMPR1B0.66837701
55CDK190.66560336
56STK40.66444022
57RPS6KA50.66122588
58NEK20.65216636
59PIM20.63701979
60GRK10.60847918
61ABL20.60472278
62EIF2AK20.58226901
63CDK70.58224216
64STK390.53069848
65CSNK1G30.52251941
66CDK80.51470637
67RPS6KA40.50866928
68ARAF0.50722684
69MAP4K20.49551791
70DAPK30.49158997
71TXK0.49096333
72PAK10.48793400
73ALK0.47618043
74CHEK10.47176412
75PRKCG0.47016525
76OXSR10.45855944
77MAP2K70.45837466
78CSNK1G10.44420156
79MYLK0.43537766
80ATM0.41710601
81INSRR0.41227552
82CSNK1E0.40755788
83MUSK0.40728946
84CSNK1G20.38511081
85BCR0.38146206
86RPS6KB20.37309858
87ERBB40.37044097
88CSNK1A10.36191448
89FGFR10.32582302
90MAP3K80.32013488
91MAP3K110.31243753
92MARK30.29176556
93CCNB10.28872900
94CLK10.28001280
95CSNK1A1L0.25416628
96PIM10.23817703
97CDK10.23475732
98MINK10.22796037
99CDK20.22120002
100CASK0.20760925

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.03527955
2Ribosome_Homo sapiens_hsa030104.99328069
3Oxidative phosphorylation_Homo sapiens_hsa001904.42321590
4Parkinsons disease_Homo sapiens_hsa050123.85491213
5RNA polymerase_Homo sapiens_hsa030203.30668909
6DNA replication_Homo sapiens_hsa030302.97906282
7Protein export_Homo sapiens_hsa030602.82778738
8Huntingtons disease_Homo sapiens_hsa050162.81514122
9Mismatch repair_Homo sapiens_hsa034302.74462979
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62081108
11Alzheimers disease_Homo sapiens_hsa050102.50063164
12Homologous recombination_Homo sapiens_hsa034402.34109190
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.29718019
14Spliceosome_Homo sapiens_hsa030402.21395431
15Base excision repair_Homo sapiens_hsa034102.01850333
16Pyrimidine metabolism_Homo sapiens_hsa002401.92109856
17Nucleotide excision repair_Homo sapiens_hsa034201.81126105
18Cardiac muscle contraction_Homo sapiens_hsa042601.73934309
19RNA transport_Homo sapiens_hsa030131.69428277
20RNA degradation_Homo sapiens_hsa030181.57966250
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56897550
22Basal transcription factors_Homo sapiens_hsa030221.54298686
23One carbon pool by folate_Homo sapiens_hsa006701.51021428
24Fanconi anemia pathway_Homo sapiens_hsa034601.39275627
25Non-homologous end-joining_Homo sapiens_hsa034501.38352892
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38075232
27Folate biosynthesis_Homo sapiens_hsa007901.30233020
28Purine metabolism_Homo sapiens_hsa002301.21278761
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19535006
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17147760
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13445533
32Sulfur relay system_Homo sapiens_hsa041221.13130349
33Pyruvate metabolism_Homo sapiens_hsa006201.12204874
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09568156
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.06361052
36Glutathione metabolism_Homo sapiens_hsa004801.05615392
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.03864960
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99008827
39Cell cycle_Homo sapiens_hsa041100.97434540
40Fatty acid elongation_Homo sapiens_hsa000620.95229177
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88741174
42Selenocompound metabolism_Homo sapiens_hsa004500.86901920
43Propanoate metabolism_Homo sapiens_hsa006400.83412456
44Steroid biosynthesis_Homo sapiens_hsa001000.81160419
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80967810
46Metabolic pathways_Homo sapiens_hsa011000.76892774
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70774944
48Sulfur metabolism_Homo sapiens_hsa009200.67829911
49Biosynthesis of amino acids_Homo sapiens_hsa012300.67072206
50Vitamin B6 metabolism_Homo sapiens_hsa007500.66794989
51Primary immunodeficiency_Homo sapiens_hsa053400.65232276
52mRNA surveillance pathway_Homo sapiens_hsa030150.62584855
53Carbon metabolism_Homo sapiens_hsa012000.62303947
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59879783
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.56662972
56Collecting duct acid secretion_Homo sapiens_hsa049660.55991825
57Peroxisome_Homo sapiens_hsa041460.55907900
58Epstein-Barr virus infection_Homo sapiens_hsa051690.53629122
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45454332
60Butanoate metabolism_Homo sapiens_hsa006500.45137385
61Phototransduction_Homo sapiens_hsa047440.41886847
62p53 signaling pathway_Homo sapiens_hsa041150.41406854
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39934354
64Vitamin digestion and absorption_Homo sapiens_hsa049770.38886120
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38580543
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37313033
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36699666
68Caffeine metabolism_Homo sapiens_hsa002320.32886715
69Chemical carcinogenesis_Homo sapiens_hsa052040.32478242
70N-Glycan biosynthesis_Homo sapiens_hsa005100.31414390
71Oocyte meiosis_Homo sapiens_hsa041140.30778829
72Regulation of autophagy_Homo sapiens_hsa041400.29183446
73Antigen processing and presentation_Homo sapiens_hsa046120.27816484
74beta-Alanine metabolism_Homo sapiens_hsa004100.27148324
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24841890
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24028655
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.23358396
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22438966
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21906300
80Systemic lupus erythematosus_Homo sapiens_hsa053220.21218629
81Tyrosine metabolism_Homo sapiens_hsa003500.21079264
82Retinol metabolism_Homo sapiens_hsa008300.20433440
83Pentose phosphate pathway_Homo sapiens_hsa000300.18299263
84Nitrogen metabolism_Homo sapiens_hsa009100.17505414
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16666450
86Arginine and proline metabolism_Homo sapiens_hsa003300.16269196
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15497971
88Tryptophan metabolism_Homo sapiens_hsa003800.13597388
89Rheumatoid arthritis_Homo sapiens_hsa053230.11787355
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11664479
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.10810659
92Vibrio cholerae infection_Homo sapiens_hsa051100.10702360
93Graft-versus-host disease_Homo sapiens_hsa053320.10412823
94Fatty acid metabolism_Homo sapiens_hsa012120.09797013
95Fat digestion and absorption_Homo sapiens_hsa049750.09773461
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09343839
97Type I diabetes mellitus_Homo sapiens_hsa049400.09216390
98Mineral absorption_Homo sapiens_hsa049780.08586042
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08250047
100Asthma_Homo sapiens_hsa053100.07586371

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