C11orf42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.19681271
2fusion of sperm to egg plasma membrane (GO:0007342)8.99357059
3protein targeting to Golgi (GO:0000042)8.49012346
4chromosome condensation (GO:0030261)8.22550400
5establishment of protein localization to Golgi (GO:0072600)8.12500320
6retrograde transport, vesicle recycling within Golgi (GO:0000301)7.92611605
7DNA packaging (GO:0006323)7.91282595
8microtubule depolymerization (GO:0007019)7.28611648
9protein polyglutamylation (GO:0018095)7.09614681
10growth hormone receptor signaling pathway (GO:0060396)7.05137864
11sperm capacitation (GO:0048240)6.98147572
12microtubule polymerization or depolymerization (GO:0031109)6.71668431
13plasma membrane fusion (GO:0045026)6.71090478
14spermatid development (GO:0007286)6.42078172
15spermatid nucleus differentiation (GO:0007289)6.28437627
16rRNA methylation (GO:0031167)6.27159757
17cellular response to growth hormone stimulus (GO:0071378)6.20320494
18single strand break repair (GO:0000012)6.10984816
19regulation of activation of Janus kinase activity (GO:0010533)6.05371763
20sperm-egg recognition (GO:0035036)6.04455672
21centriole replication (GO:0007099)6.02846747
22spermatogenesis (GO:0007283)5.89830964
23protein localization to Golgi apparatus (GO:0034067)5.89582843
24male gamete generation (GO:0048232)5.87850476
25centriole assembly (GO:0098534)5.87803188
26regulation of centriole replication (GO:0046599)5.74033326
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.70423548
28negative regulation of inclusion body assembly (GO:0090084)5.68116309
29microtubule severing (GO:0051013)5.67060256
30multicellular organism reproduction (GO:0032504)5.52626528
31binding of sperm to zona pellucida (GO:0007339)5.50679009
32gamete generation (GO:0007276)5.42356266
33seminiferous tubule development (GO:0072520)5.39061567
34calcium ion-dependent exocytosis (GO:0017156)5.26556555
35glomerular visceral epithelial cell development (GO:0072015)5.24697422
36axonemal dynein complex assembly (GO:0070286)5.21745186
37reproduction (GO:0000003)5.20324139
38nuclear pore complex assembly (GO:0051292)5.19571737
39phosphatidylethanolamine metabolic process (GO:0046337)5.19515045
40rRNA modification (GO:0000154)5.11651341
41motile cilium assembly (GO:0044458)5.10071226
42sexual reproduction (GO:0019953)5.07759360
43cell-cell recognition (GO:0009988)5.05575533
44response to pheromone (GO:0019236)4.95307817
45glomerular epithelial cell development (GO:0072310)4.83491339
46microtubule nucleation (GO:0007020)4.58796204
47regulation of cilium movement (GO:0003352)4.47919915
48single fertilization (GO:0007338)4.47242503
49RNA destabilization (GO:0050779)4.34657785
50multicellular organismal reproductive process (GO:0048609)4.32482425
51regulation of Rab GTPase activity (GO:0032313)4.29776854
52positive regulation of Rab GTPase activity (GO:0032851)4.29776854
53cilium or flagellum-dependent cell motility (GO:0001539)4.29682644
54cell wall macromolecule catabolic process (GO:0016998)4.23213335
55multicellular organismal movement (GO:0050879)4.19357408
56musculoskeletal movement (GO:0050881)4.19357408
57nucleus organization (GO:0006997)4.17161205
58fertilization (GO:0009566)4.10831033
59modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02944405
60positive regulation by organism of defense response of other organism involved in symbiotic interact4.02944405
61modulation by symbiont of host immune response (GO:0052553)4.02944405
62positive regulation by symbiont of host defense response (GO:0052509)4.02944405
63modulation by symbiont of host defense response (GO:0052031)4.02944405
64modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02944405
65nuclear pore organization (GO:0006999)3.93684882
66regulation of inclusion body assembly (GO:0090083)3.92471246
67cell wall macromolecule metabolic process (GO:0044036)3.88317038
68germ cell development (GO:0007281)3.86940063
69pore complex assembly (GO:0046931)3.83685205
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.78903322
71chromatin silencing (GO:0006342)3.72472944
72cellular process involved in reproduction in multicellular organism (GO:0022412)3.72237619
73epithelial cilium movement (GO:0003351)3.67039463
74macrophage activation involved in immune response (GO:0002281)3.61983566
75regulation of transcription involved in cell fate commitment (GO:0060850)3.59292053
76positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.48596400
77positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.45161716
78histone H3-K9 demethylation (GO:0033169)3.44277668
79male meiosis I (GO:0007141)3.38414803
80response to growth hormone (GO:0060416)3.27225564
81negative regulation of Rho protein signal transduction (GO:0035024)3.23818032
82cilium movement (GO:0003341)3.19089450
83glycerol ether metabolic process (GO:0006662)3.17249606
84membrane protein intracellular domain proteolysis (GO:0031293)3.14900516
85piRNA metabolic process (GO:0034587)3.09256115
86intra-Golgi vesicle-mediated transport (GO:0006891)3.07376739
87male meiosis (GO:0007140)3.05643849
88regulation of T-helper 2 cell differentiation (GO:0045628)2.96594640
89JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.93943295
90protein depolymerization (GO:0051261)2.89658284
91ether metabolic process (GO:0018904)2.88602501
92cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.86323038
93positive regulation of receptor internalization (GO:0002092)2.83821390
94regulation of ARF GTPase activity (GO:0032312)2.82478467
95DNA methylation involved in gamete generation (GO:0043046)2.80197995
96microglial cell activation (GO:0001774)2.77738140
97organic cation transport (GO:0015695)2.69392785
98DNA conformation change (GO:0071103)2.68680022
99regulation of interferon-beta biosynthetic process (GO:0045357)2.65045727
100sperm motility (GO:0030317)10.3270317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.45656646
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.22119571
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81771420
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52774901
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.31641059
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31641059
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24462462
8DROSHA_22980978_ChIP-Seq_HELA_Human2.16059432
9IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.87895484
10CBP_20019798_ChIP-Seq_JUKART_Human1.87895484
11FUS_26573619_Chip-Seq_HEK293_Human1.81997604
12ARNT_22903824_ChIP-Seq_MCF-7_Human1.78211220
13RAC3_21632823_ChIP-Seq_H3396_Human1.77627069
14EZH2_22144423_ChIP-Seq_EOC_Human1.71919701
15CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71786529
16ER_23166858_ChIP-Seq_MCF-7_Human1.66719872
17SMC4_20622854_ChIP-Seq_HELA_Human1.66124916
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.62840802
19CBX2_22325352_ChIP-Seq_293T-Rex_Human1.60229421
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54298489
21SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.54143235
22* SMAD4_21741376_ChIP-Seq_EPCs_Human1.53139389
23* ERA_21632823_ChIP-Seq_H3396_Human1.53077064
24HNFA_21074721_ChIP-Seq_CACO-2_Human1.53045071
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51646484
26RBPJ_21746931_ChIP-Seq_IB4_Human1.48441024
27NFYB_21822215_ChIP-Seq_K562_Human1.47191363
28ETV1_20927104_ChIP-Seq_GIST48_Human1.46885631
29CTCF_27219007_Chip-Seq_Bcells_Human1.46369601
30EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.44027383
31CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.41089042
32TAF2_19829295_ChIP-Seq_ESCs_Human1.40644768
33TBL1_22424771_ChIP-Seq_293T_Human1.40284027
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40225535
35AR_25329375_ChIP-Seq_VCAP_Human1.39967234
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37069652
37PKCTHETA_26484144_Chip-Seq_BREAST_Human1.36941211
38LXR_22292898_ChIP-Seq_THP-1_Human1.34753508
39BCL6_27268052_Chip-Seq_Bcells_Human1.34381485
40RUNX_20019798_ChIP-Seq_JUKART_Human1.33654050
41WDR5_24793694_ChIP-Seq_LNCAP_Human1.32835234
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.32724268
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32203028
44TP63_22573176_ChIP-Seq_HFKS_Human1.30339248
45ELF1_20517297_ChIP-Seq_JURKAT_Human1.30323499
46P68_20966046_ChIP-Seq_HELA_Human1.30005871
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.29948231
48PHF8_20622853_ChIP-Seq_HELA_Human1.29729797
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29308565
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25612834
51SMAD3_21741376_ChIP-Seq_ESCs_Human1.24839878
52MYC_19829295_ChIP-Seq_ESCs_Human1.24732313
53GATA6_21074721_ChIP-Seq_CACO-2_Human1.23971156
54AUTS2_25519132_ChIP-Seq_293T-REX_Human1.23224432
55NFYA_21822215_ChIP-Seq_K562_Human1.23206702
56PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.22850295
57AHR_22903824_ChIP-Seq_MCF-7_Human1.22510734
58EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21892280
59NANOG_20526341_ChIP-Seq_ESCs_Human1.21862260
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21358829
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18888134
62P300_19829295_ChIP-Seq_ESCs_Human1.18210380
63BCOR_27268052_Chip-Seq_Bcells_Human1.18192255
64OCT4_20526341_ChIP-Seq_ESCs_Human1.17833978
65STAT3_23295773_ChIP-Seq_U87_Human1.17101100
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.16709659
67ERG_20517297_ChIP-Seq_VCAP_Human1.16387809
68GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16253431
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15948321
70TP53_18474530_ChIP-ChIP_U2OS_Human1.14969441
71KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.13954350
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.13238210
73PHF8_20622854_ChIP-Seq_HELA_Human1.12997572
74VDR_24787735_ChIP-Seq_THP-1_Human1.12479964
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11918531
76CEBPB_22108803_ChIP-Seq_LS180_Human1.11434631
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11041697
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.09195736
79E2F1_20622854_ChIP-Seq_HELA_Human1.08085230
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07954438
81KLF4_19829295_ChIP-Seq_ESCs_Human1.07751008
82GATA1_19941826_ChIP-Seq_K562_Human1.06204364
83TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.05348031
84P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.04769787
85FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04668084
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03300266
87SA1_27219007_Chip-Seq_Bcells_Human1.03260897
88ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02778573
89SMAD4_21741376_ChIP-Seq_HESCs_Human1.02242753
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01972922
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01923054
92SMRT_27268052_Chip-Seq_Bcells_Human1.01026556
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00688898
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98779349
95KLF5_25053715_ChIP-Seq_YYC3_Human0.98469337
96RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98428403
97KDM2B_26808549_Chip-Seq_REH_Human0.98047567
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.97659611
99GF1_26923725_Chip-Seq_HPCs_Mouse0.97652743
100SOX2_22085726_ChIP-Seq_NPCs_Mouse0.97079369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition6.77336033
2MP0005377_hearing/vestibular/ear_phenot5.35658954
3MP0003878_abnormal_ear_physiology5.35658954
4MP0001348_abnormal_lacrimal_gland4.76763367
5MP0003698_abnormal_male_reproductive4.00855436
6MP0005670_abnormal_white_adipose3.55978610
7MP0001929_abnormal_gametogenesis3.50768429
8MP0000678_abnormal_parathyroid_gland2.40026146
9MP0005423_abnormal_somatic_nervous2.35242933
10MP0005310_abnormal_salivary_gland2.29915896
11MP0002161_abnormal_fertility/fecundity2.16247886
12MP0005410_abnormal_fertilization10.4091552
13MP0001486_abnormal_startle_reflex1.81825385
14MP0003646_muscle_fatigue1.76175658
15MP0003718_maternal_effect1.62321998
16MP0003879_abnormal_hair_cell1.60851198
17MP0004859_abnormal_synaptic_plasticity1.59526956
18MP0002210_abnormal_sex_determination1.53112173
19MP0001485_abnormal_pinna_reflex1.48905030
20MP0003011_delayed_dark_adaptation1.46208539
21MP0002249_abnormal_larynx_morphology1.39755811
22MP0002282_abnormal_trachea_morphology1.39286436
23MP0009115_abnormal_fat_cell1.36950323
24MP0002132_abnormal_respiratory_system1.31373136
25MP0004742_abnormal_vestibular_system1.31022802
26MP0001145_abnormal_male_reproductive1.25185745
27MP0005379_endocrine/exocrine_gland_phen1.22875505
28MP0005248_abnormal_Harderian_gland1.21350655
29MP0001765_abnormal_ion_homeostasis1.20080518
30MP0008877_abnormal_DNA_methylation1.19374278
31MP0000653_abnormal_sex_gland1.17717565
32MP0005666_abnormal_adipose_tissue1.14452758
33MP0004233_abnormal_muscle_weight1.14010060
34MP0001984_abnormal_olfaction1.12626497
35MP0004782_abnormal_surfactant_physiolog1.10963085
36MP0009053_abnormal_anal_canal1.09328105
37MP0001963_abnormal_hearing_physiology1.02087079
38MP0004510_myositis0.98603848
39MP0008961_abnormal_basal_metabolism0.94495198
40MP0001666_abnormal_nutrient_absorption0.91636205
41MP0002127_abnormal_cardiovascular_syste0.90586199
42MP0003828_pulmonary_edema0.89562531
43MP0002139_abnormal_hepatobiliary_system0.89365238
44MP0005253_abnormal_eye_physiology0.79743236
45MP0005395_other_phenotype0.79348037
46MP0001968_abnormal_touch/_nociception0.76672812
47MP0003329_amyloid_beta_deposits0.73524559
48MP0005375_adipose_tissue_phenotype0.73476079
49MP0002067_abnormal_sensory_capabilities0.71952322
50MP0002735_abnormal_chemical_nociception0.68591043
51MP0000026_abnormal_inner_ear0.67827545
52MP0008995_early_reproductive_senescence0.67596759
53MP0000955_abnormal_spinal_cord0.66939609
54MP0002928_abnormal_bile_duct0.65521442
55MP0000534_abnormal_ureter_morphology0.65478593
56MP0002234_abnormal_pharynx_morphology0.62143842
57MP0010307_abnormal_tumor_latency0.61406762
58MP0001545_abnormal_hematopoietic_system0.60935746
59MP0005397_hematopoietic_system_phenotyp0.60935746
60MP0003077_abnormal_cell_cycle0.58329471
61MP0005551_abnormal_eye_electrophysiolog0.57510345
62MP0002229_neurodegeneration0.55148823
63MP0003091_abnormal_cell_migration0.55121546
64MP0005083_abnormal_biliary_tract0.52951453
65MP0005647_abnormal_sex_gland0.50107399
66MP0005595_abnormal_vascular_smooth0.50027636
67MP0009278_abnormal_bone_marrow0.48551492
68MP0010234_abnormal_vibrissa_follicle0.43277246
69MP0003115_abnormal_respiratory_system0.42050634
70MP0001440_abnormal_grooming_behavior0.41813921
71MP0002572_abnormal_emotion/affect_behav0.41657068
72MP0008569_lethality_at_weaning0.41640719
73MP0000230_abnormal_systemic_arterial0.41416069
74MP0005391_vision/eye_phenotype0.41279147
75MP0000249_abnormal_blood_vessel0.40489723
76MP0001835_abnormal_antigen_presentation0.40437367
77MP0003172_abnormal_lysosome_physiology0.38928405
78MP0005535_abnormal_body_temperature0.38876205
79MP0003137_abnormal_impulse_conducting0.38407772
80MP0000049_abnormal_middle_ear0.37922483
81MP0000681_abnormal_thyroid_gland0.37300437
82MP0004085_abnormal_heartbeat0.36936731
83MP0004084_abnormal_cardiac_muscle0.36436537
84MP0003635_abnormal_synaptic_transmissio0.35724786
85MP0002184_abnormal_innervation0.35029010
86MP0002734_abnormal_mechanical_nocicepti0.33211026
87MP0008874_decreased_physiological_sensi0.33056948
88MP0004484_altered_response_of0.32995728
89MP0002138_abnormal_hepatobiliary_system0.32940645
90MP0002998_abnormal_bone_remodeling0.31207048
91MP0002557_abnormal_social/conspecific_i0.30852199
92MP0001501_abnormal_sleep_pattern0.30840743
93MP0001905_abnormal_dopamine_level0.30670270
94MP0000003_abnormal_adipose_tissue0.29901794
95MP0004036_abnormal_muscle_relaxation0.29846628
96MP0003699_abnormal_female_reproductive0.29416502
97MP0002971_abnormal_brown_adipose0.28640415
98MP0002932_abnormal_joint_morphology0.28581174
99MP0005636_abnormal_mineral_homeostasis0.28476862
100MP0000470_abnormal_stomach_morphology0.27994859

Predicted human phenotypes

RankGene SetZ-score
1Tubulointerstitial nephritis (HP:0001970)6.44797180
2Chronic hepatic failure (HP:0100626)6.33612635
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.25372740
4Severe visual impairment (HP:0001141)5.89898258
5Asymmetric septal hypertrophy (HP:0001670)5.74197155
6Absent/shortened dynein arms (HP:0200106)5.42775586
7Dynein arm defect of respiratory motile cilia (HP:0012255)5.42775586
8Resting tremor (HP:0002322)5.22028328
9Cone-rod dystrophy (HP:0000548)4.94623071
10Menstrual irregularities (HP:0000858)4.89747887
11Nasal polyposis (HP:0100582)4.50121781
12Hyperkalemia (HP:0002153)4.37177036
13Male infertility (HP:0003251)4.29850404
14Bony spicule pigmentary retinopathy (HP:0007737)4.18068140
15Aplasia/Hypoplasia of the earlobes (HP:0009906)3.93128674
16Progressive sensorineural hearing impairment (HP:0000408)3.90315374
17Renovascular hypertension (HP:0100817)3.88500179
18Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.87933981
19Truncal obesity (HP:0001956)3.83603418
20Abnormal respiratory motile cilium physiology (HP:0012261)3.76391856
21Postural instability (HP:0002172)3.70225790
22Abnormal ciliary motility (HP:0012262)3.66870009
23Attenuation of retinal blood vessels (HP:0007843)3.64259774
24Hypoalphalipoproteinemia (HP:0003233)3.62454830
25Abnormality of the nasal mucosa (HP:0000433)3.59377267
26Growth hormone deficiency (HP:0000824)3.55270337
27Abnormal respiratory motile cilium morphology (HP:0005938)3.51898658
28Abnormal respiratory epithelium morphology (HP:0012253)3.51898658
29Hypoplasia of the thymus (HP:0000778)3.51680894
30Infertility (HP:0000789)3.48927140
31Abnormality of macular pigmentation (HP:0008002)3.40594083
32Amelogenesis imperfecta (HP:0000705)3.30758666
33Portal hypertension (HP:0001409)3.08834006
34Abnormality of dental color (HP:0011073)3.08112875
35Stage 5 chronic kidney disease (HP:0003774)3.07698172
36Impulsivity (HP:0100710)3.01578212
37Abnormality of the hepatic vasculature (HP:0006707)2.98221221
38Insulin-resistant diabetes mellitus (HP:0000831)2.98116586
39Severe short stature (HP:0003510)2.86168857
40Intellectual disability, moderate (HP:0002342)2.84081906
41Progressive cerebellar ataxia (HP:0002073)2.83121923
42Tubulointerstitial abnormality (HP:0001969)2.70040671
43Enlarged epiphyses (HP:0010580)2.69390422
44Facial shape deformation (HP:0011334)2.68087192
45Potter facies (HP:0002009)2.68087192
46Subcapsular cataract (HP:0000523)2.66998558
47Progressive hearing impairment (HP:0001730)2.66568628
48Focal segmental glomerulosclerosis (HP:0000097)2.62738420
49Abnormal spermatogenesis (HP:0008669)2.60094178
50Gingivitis (HP:0000230)2.59215802
51Osteomalacia (HP:0002749)2.48506186
52Hypolipoproteinemia (HP:0010981)2.46474679
53Bell-shaped thorax (HP:0001591)2.43069821
54Recurrent pneumonia (HP:0006532)2.37227640
55Obsessive-compulsive behavior (HP:0000722)2.34276188
56Increased purine levels (HP:0004368)2.31461490
57Hyperuricemia (HP:0002149)2.31461490
58Sandal gap (HP:0001852)2.22199157
59Abnormality of the costochondral junction (HP:0000919)2.21096339
60Abnormal rod and cone electroretinograms (HP:0008323)2.19667228
61Abnormality of potassium homeostasis (HP:0011042)2.18105638
62Abnormality of the fingertips (HP:0001211)2.14432795
63Ventricular tachycardia (HP:0004756)2.02988824
64Rhinitis (HP:0012384)2.02093907
65Abnormal urine output (HP:0012590)1.99880822
66Hypoplastic ischia (HP:0003175)1.98091940
67Azoospermia (HP:0000027)1.96264542
68Nephronophthisis (HP:0000090)1.95902438
69Abnormal drinking behavior (HP:0030082)1.93800997
70Polydipsia (HP:0001959)1.93800997
71Glomerulosclerosis (HP:0000096)1.92015827
72Chronic bronchitis (HP:0004469)1.90774370
73Neoplasm of the heart (HP:0100544)1.86383046
74Bilateral sensorineural hearing impairment (HP:0008619)1.85371789
75Abnormality of the ischium (HP:0003174)1.81897842
76Abnormality of the aortic arch (HP:0012303)1.80928312
77Abnormality of the renal medulla (HP:0100957)1.80144267
78Insulin resistance (HP:0000855)1.78243611
79Hypoalbuminemia (HP:0003073)1.75470583
80Abnormal albumin level (HP:0012116)1.75470583
81Abnormality of renal excretion (HP:0011036)1.73823930
82Deep palmar crease (HP:0006191)1.73648966
83Bronchiectasis (HP:0002110)1.73361067
84Horizontal nystagmus (HP:0000666)1.73307270
85Slow saccadic eye movements (HP:0000514)1.69791570
86Bradycardia (HP:0001662)1.69777806
87Abnormality of chloride homeostasis (HP:0011422)1.69121914
88Myokymia (HP:0002411)1.66572627
89Acanthosis nigricans (HP:0000956)1.64814445
90Gastrointestinal infarctions (HP:0005244)1.64381947
91Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.63636148
92Termporal pattern (HP:0011008)1.63132193
93Insidious onset (HP:0003587)1.63132193
94Flattened epiphyses (HP:0003071)1.62747619
95Esophageal varix (HP:0002040)1.62102919
96Widely patent fontanelles and sutures (HP:0004492)1.60256743
97Convex nasal ridge (HP:0000444)1.58216739
98Underdeveloped nasal alae (HP:0000430)1.58098806
99Polyuria (HP:0000103)1.56190219
100Nephritis (HP:0000123)1.55578462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.79655979
2BRD45.21573311
3INSRR4.10005532
4PLK23.55577628
5PNCK3.27725979
6CAMK1G2.99203900
7TESK12.95809222
8PIK3CG2.85766370
9MAP3K112.23709521
10BLK2.23601778
11DDR22.19577437
12MAP4K22.11740580
13STK381.98161695
14KSR21.87571540
15PRKD31.75854809
16CDK121.70277839
17PDK11.63660093
18PDPK11.63415394
19CAMK1D1.59384489
20TYRO31.56221962
21STK38L1.55281219
22WNK11.49567326
23MAP3K11.43234498
24MST1R1.32239740
25PTK2B1.28157510
26NEK61.27616454
27MAP3K91.23329380
28BRAF1.10740169
29MAPK151.03477799
30AKT31.01424294
31JAK30.97968158
32DYRK1B0.96368576
33MAP3K20.95448941
34MAP4K10.90340620
35RIPK40.89829097
36CDK190.88155037
37MAP3K130.83729300
38ARAF0.82128039
39MARK20.79733049
40TAOK10.68174439
41PRKG20.67322671
42PRKAA20.66914893
43OXSR10.64899566
44SGK2230.64317593
45SGK4940.64317593
46SIK20.63262557
47LATS10.61397669
48CDK70.60234878
49GRK60.54321433
50CAMK10.53950133
51SGK20.50777886
52NTRK30.44124300
53MARK10.43603199
54MAP2K20.42184486
55PRKG10.41263763
56JAK20.40901690
57CAMK40.39852638
58TIE10.38832060
59SGK10.38454285
60RPS6KA20.37321221
61SGK30.36054472
62MAP2K40.36014176
63RPS6KA10.35925757
64MAP3K70.35298237
65MAPK10.35067654
66ACVR1B0.34711979
67MAP3K80.34145130
68STK110.32526378
69PRKCZ0.32251057
70CDK20.31541638
71GSK3B0.30102874
72CDK10.29831044
73LATS20.29101476
74CSK0.27388529
75CDK40.26191280
76MAPK80.24835582
77MTOR0.24795352
78DYRK30.24767826
79CHEK10.24687944
80RAF10.23779396
81BRSK20.21046294
82CSF1R0.20115429
83MAPK100.19974303
84BRSK10.19818651
85ICK0.19553302
86KSR10.19479882
87SYK0.18845472
88MOS0.17776297
89CDK30.14886599
90AKT10.14755822
91RPS6KC10.13991637
92RPS6KL10.13991637
93ERBB20.13064283
94MAPK90.11030828
95HCK0.10297886
96MET0.08706465
97IRAK40.08120176
98MAPK140.07897345
99RPS6KA60.07644299
100ZAP700.07177252

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000616.74219474
2Olfactory transduction_Homo sapiens_hsa047403.00735244
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84938443
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44181035
5Dorso-ventral axis formation_Homo sapiens_hsa043202.08828858
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.59758458
7Type II diabetes mellitus_Homo sapiens_hsa049301.45155457
8Adipocytokine signaling pathway_Homo sapiens_hsa049201.44665517
9Glycerophospholipid metabolism_Homo sapiens_hsa005641.41039784
10Non-small cell lung cancer_Homo sapiens_hsa052231.37882346
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36799683
12Fatty acid metabolism_Homo sapiens_hsa012121.36788771
13Caffeine metabolism_Homo sapiens_hsa002321.28760016
14Taste transduction_Homo sapiens_hsa047421.26404135
15RNA transport_Homo sapiens_hsa030131.21254535
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.20790103
17Fatty acid degradation_Homo sapiens_hsa000711.18803870
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.12938323
19Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11488961
20Estrogen signaling pathway_Homo sapiens_hsa049151.11260995
21ABC transporters_Homo sapiens_hsa020101.10497536
22Inositol phosphate metabolism_Homo sapiens_hsa005621.09674373
23VEGF signaling pathway_Homo sapiens_hsa043701.08506167
24Glutamatergic synapse_Homo sapiens_hsa047241.05886540
25Influenza A_Homo sapiens_hsa051641.04494812
26Acute myeloid leukemia_Homo sapiens_hsa052211.01372697
27Bile secretion_Homo sapiens_hsa049761.00662530
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.00612279
29Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99678578
30PPAR signaling pathway_Homo sapiens_hsa033200.97268001
31B cell receptor signaling pathway_Homo sapiens_hsa046620.96504127
32cAMP signaling pathway_Homo sapiens_hsa040240.96304626
33Phenylalanine metabolism_Homo sapiens_hsa003600.95023669
34Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94224956
35Long-term potentiation_Homo sapiens_hsa047200.94031221
36Morphine addiction_Homo sapiens_hsa050320.93936973
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89732482
38Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87119185
39MAPK signaling pathway_Homo sapiens_hsa040100.86318150
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86050575
41ErbB signaling pathway_Homo sapiens_hsa040120.85984685
42Salivary secretion_Homo sapiens_hsa049700.83026755
43Antigen processing and presentation_Homo sapiens_hsa046120.80389829
44Osteoclast differentiation_Homo sapiens_hsa043800.79427172
45Oocyte meiosis_Homo sapiens_hsa041140.78603099
46Glioma_Homo sapiens_hsa052140.77788910
47Gastric acid secretion_Homo sapiens_hsa049710.75694190
48Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75027769
49Prolactin signaling pathway_Homo sapiens_hsa049170.72091486
50Endocytosis_Homo sapiens_hsa041440.71499659
51Cholinergic synapse_Homo sapiens_hsa047250.71455264
52Circadian entrainment_Homo sapiens_hsa047130.70089627
53Notch signaling pathway_Homo sapiens_hsa043300.69025265
54Prostate cancer_Homo sapiens_hsa052150.68844658
55Leishmaniasis_Homo sapiens_hsa051400.67948056
56Nicotine addiction_Homo sapiens_hsa050330.67662890
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.67351410
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.66304700
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65867389
60Oxytocin signaling pathway_Homo sapiens_hsa049210.64621753
61Viral myocarditis_Homo sapiens_hsa054160.63233005
62Choline metabolism in cancer_Homo sapiens_hsa052310.61704820
63Pancreatic cancer_Homo sapiens_hsa052120.61674074
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60874682
65Tuberculosis_Homo sapiens_hsa051520.60839530
66Protein digestion and absorption_Homo sapiens_hsa049740.60134008
67Calcium signaling pathway_Homo sapiens_hsa040200.57396945
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57284155
69Arginine biosynthesis_Homo sapiens_hsa002200.56697841
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56348801
71Endometrial cancer_Homo sapiens_hsa052130.55957358
72mTOR signaling pathway_Homo sapiens_hsa041500.55680397
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54911443
74Chemokine signaling pathway_Homo sapiens_hsa040620.54797468
75Synaptic vesicle cycle_Homo sapiens_hsa047210.54434227
76Pancreatic secretion_Homo sapiens_hsa049720.53862803
77Hepatitis B_Homo sapiens_hsa051610.53083603
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52810226
79Hedgehog signaling pathway_Homo sapiens_hsa043400.50383362
80Platelet activation_Homo sapiens_hsa046110.49882328
81T cell receptor signaling pathway_Homo sapiens_hsa046600.49094206
82Butanoate metabolism_Homo sapiens_hsa006500.48666092
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48390332
84Chronic myeloid leukemia_Homo sapiens_hsa052200.46737314
85Renal cell carcinoma_Homo sapiens_hsa052110.46707677
86Renin secretion_Homo sapiens_hsa049240.46629902
87Autoimmune thyroid disease_Homo sapiens_hsa053200.46232092
88Toxoplasmosis_Homo sapiens_hsa051450.45166323
89Gap junction_Homo sapiens_hsa045400.42696803
90Type I diabetes mellitus_Homo sapiens_hsa049400.42693792
91GABAergic synapse_Homo sapiens_hsa047270.42367184
92Allograft rejection_Homo sapiens_hsa053300.42116551
93Renin-angiotensin system_Homo sapiens_hsa046140.41833950
94FoxO signaling pathway_Homo sapiens_hsa040680.41767068
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.41120728
96Graft-versus-host disease_Homo sapiens_hsa053320.38654190
97Amphetamine addiction_Homo sapiens_hsa050310.38631756
98Lysine degradation_Homo sapiens_hsa003100.38250927
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38167848
100Insulin signaling pathway_Homo sapiens_hsa049100.38083252

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