C11orf87

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)7.34900505
2synaptic vesicle docking involved in exocytosis (GO:0016081)6.94207027
3glutamate secretion (GO:0014047)6.43787831
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.34473937
5synaptic vesicle exocytosis (GO:0016079)6.09101617
6regulation of synaptic vesicle exocytosis (GO:2000300)5.69074951
7membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.44298558
8cellular potassium ion homeostasis (GO:0030007)5.44252318
9ionotropic glutamate receptor signaling pathway (GO:0035235)5.39124071
10cerebellar granule cell differentiation (GO:0021707)5.31026540
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27254923
12neuronal action potential propagation (GO:0019227)5.26420335
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20144476
14regulation of synaptic vesicle transport (GO:1902803)5.02245827
15sodium ion export (GO:0071436)5.01455042
16neurotransmitter secretion (GO:0007269)4.86961840
17synaptic transmission, glutamatergic (GO:0035249)4.82762513
18vocalization behavior (GO:0071625)4.64023222
19postsynaptic membrane organization (GO:0001941)4.58874864
20protein localization to synapse (GO:0035418)4.58786092
21exploration behavior (GO:0035640)4.57968546
22neuron-neuron synaptic transmission (GO:0007270)4.56692456
23gamma-aminobutyric acid signaling pathway (GO:0007214)4.46921843
24regulation of neuronal synaptic plasticity (GO:0048168)4.46444078
25glutamate receptor signaling pathway (GO:0007215)4.45499141
26locomotory exploration behavior (GO:0035641)4.45085847
27neuron cell-cell adhesion (GO:0007158)4.43768030
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.38180712
29positive regulation of dendritic spine morphogenesis (GO:0061003)4.35209752
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.28794857
31layer formation in cerebral cortex (GO:0021819)4.25123293
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15146645
33gamma-aminobutyric acid transport (GO:0015812)4.11864928
34regulation of glutamate receptor signaling pathway (GO:1900449)4.00941309
35regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00351855
36regulation of excitatory postsynaptic membrane potential (GO:0060079)4.00275453
37positive regulation of synapse maturation (GO:0090129)3.97075215
38cerebellar Purkinje cell differentiation (GO:0021702)3.93428921
39neurotransmitter transport (GO:0006836)3.92685244
40regulation of dendritic spine morphogenesis (GO:0061001)3.92395410
41regulation of synapse structural plasticity (GO:0051823)3.90983946
42presynaptic membrane assembly (GO:0097105)3.90682131
43regulation of neurotransmitter secretion (GO:0046928)3.90427988
44negative regulation of dendrite morphogenesis (GO:0050774)3.90026626
45neurotransmitter-gated ion channel clustering (GO:0072578)3.89137158
46regulation of voltage-gated calcium channel activity (GO:1901385)3.85914603
47cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.84907429
48positive regulation of dendritic spine development (GO:0060999)3.82353139
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.81058326
50synaptic vesicle endocytosis (GO:0048488)3.80848132
51negative regulation of synaptic transmission, GABAergic (GO:0032229)3.80575406
52L-amino acid import (GO:0043092)3.78770169
53presynaptic membrane organization (GO:0097090)3.78120618
54regulation of postsynaptic membrane potential (GO:0060078)3.74046353
55regulation of synaptic plasticity (GO:0048167)3.73497011
56dendritic spine morphogenesis (GO:0060997)3.70018815
57membrane depolarization during action potential (GO:0086010)3.67366803
58regulation of vesicle fusion (GO:0031338)3.66455645
59cellular sodium ion homeostasis (GO:0006883)3.63034817
60axonal fasciculation (GO:0007413)3.60368726
61long-term memory (GO:0007616)3.58587760
62regulation of neurotransmitter levels (GO:0001505)3.55988227
63amino acid import (GO:0043090)3.55542103
64regulation of neurotransmitter transport (GO:0051588)3.54793456
65potassium ion homeostasis (GO:0055075)3.51833613
66membrane depolarization (GO:0051899)3.51431571
67neuronal ion channel clustering (GO:0045161)3.50604474
68positive regulation of membrane potential (GO:0045838)3.48577980
69transmission of nerve impulse (GO:0019226)3.47518511
70regulation of dendritic spine development (GO:0060998)3.47517091
71neuron recognition (GO:0008038)3.44995936
72cell communication by electrical coupling (GO:0010644)3.41928951
73detection of calcium ion (GO:0005513)3.39001582
74auditory behavior (GO:0031223)3.37793720
75serotonin metabolic process (GO:0042428)3.35064949
76positive regulation of neurotransmitter secretion (GO:0001956)3.32257334
77short-term memory (GO:0007614)3.30935690
78cell differentiation in hindbrain (GO:0021533)3.29674029
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.28977005
80cerebellar Purkinje cell layer development (GO:0021680)3.28893570
81neuromuscular synaptic transmission (GO:0007274)3.26098654
82neuromuscular process controlling balance (GO:0050885)3.25924509
83potassium ion import (GO:0010107)3.22816384
84positive regulation of neurotransmitter transport (GO:0051590)3.22507453
85regulation of synaptic transmission, glutamatergic (GO:0051966)3.21772102
86C4-dicarboxylate transport (GO:0015740)3.20031777
87synaptic transmission (GO:0007268)3.19215800
88startle response (GO:0001964)3.16572440
89regulation of synaptic transmission (GO:0050804)3.16382069
90acidic amino acid transport (GO:0015800)3.13365269
91regulation of synapse maturation (GO:0090128)3.07660665
92adult walking behavior (GO:0007628)3.04369817
93prepulse inhibition (GO:0060134)3.04100129
94regulation of dendrite morphogenesis (GO:0048814)3.03340960
95long-term synaptic potentiation (GO:0060291)3.02177032
96proline transport (GO:0015824)3.00459857
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.99965186
98dendritic spine organization (GO:0097061)2.99951702
99establishment of mitochondrion localization (GO:0051654)2.98754018
100response to histamine (GO:0034776)2.97928677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02691917
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.80505613
3GBX2_23144817_ChIP-Seq_PC3_Human3.48846559
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24721783
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10088398
6REST_21632747_ChIP-Seq_MESCs_Mouse3.07871711
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07209723
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66923703
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66923703
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.62166473
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60197290
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59407838
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.58527849
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54515946
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.52909064
16DROSHA_22980978_ChIP-Seq_HELA_Human2.51406788
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50022856
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.46479652
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43433791
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.41644882
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.35736871
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.33825379
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21205097
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.21056010
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20573116
26TAF15_26573619_Chip-Seq_HEK293_Human1.93724289
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.93115348
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91473114
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88734252
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74951625
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70749043
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70460763
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67618132
34* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63510810
35AR_21572438_ChIP-Seq_LNCaP_Human1.55891795
36SMAD4_21799915_ChIP-Seq_A2780_Human1.53183448
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.53061097
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52837703
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49513472
40RNF2_27304074_Chip-Seq_NSC_Mouse1.47807512
41RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47320093
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44151243
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43102581
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42309733
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41193760
46* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41048569
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35195323
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33643617
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.31382228
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27014102
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24275848
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23962932
53P300_19829295_ChIP-Seq_ESCs_Human1.23182471
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.21507267
55* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19965740
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19789967
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16232704
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15861224
59AR_19668381_ChIP-Seq_PC3_Human1.14172620
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.14084210
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.12470574
62LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12280366
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11169431
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10376551
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09786841
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09602379
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09602379
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08515974
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08250944
70GATA1_26923725_Chip-Seq_HPCs_Mouse1.07656181
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04380895
72TCF4_23295773_ChIP-Seq_U87_Human1.03527644
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03466640
74* AR_25329375_ChIP-Seq_VCAP_Human1.03310782
75STAT3_23295773_ChIP-Seq_U87_Human1.02704629
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.02187779
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01253693
78RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99466328
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98662647
80ERG_21242973_ChIP-ChIP_JURKAT_Human0.98522711
81IGF1R_20145208_ChIP-Seq_DFB_Human0.98120775
82SOX9_26525672_Chip-Seq_HEART_Mouse0.97933652
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96662080
84FUS_26573619_Chip-Seq_HEK293_Human0.96627171
85FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95400290
86ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92294957
87JUN_21703547_ChIP-Seq_K562_Human0.92127348
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91993228
89TP53_18474530_ChIP-ChIP_U2OS_Human0.91802595
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91759882
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91324482
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91226994
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90557351
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.89890936
95KDM2B_26808549_Chip-Seq_REH_Human0.86989942
96VDR_22108803_ChIP-Seq_LS180_Human0.86446753
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.86281018
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86108166
99CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85940668
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.85307748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.46669669
2MP0003880_abnormal_central_pattern5.40227165
3MP0004270_analgesia4.34792962
4MP0003635_abnormal_synaptic_transmissio4.10789771
5MP0009046_muscle_twitch3.56162759
6MP0002064_seizures3.52717408
7MP0009745_abnormal_behavioral_response3.39982904
8MP0002063_abnormal_learning/memory/cond3.31941856
9MP0002272_abnormal_nervous_system3.24881049
10MP0005423_abnormal_somatic_nervous3.07098874
11MP0001968_abnormal_touch/_nociception2.97060194
12MP0001486_abnormal_startle_reflex2.93344063
13MP0002734_abnormal_mechanical_nocicepti2.86638346
14MP0002572_abnormal_emotion/affect_behav2.79310408
15MP0002735_abnormal_chemical_nociception2.65210181
16MP0001501_abnormal_sleep_pattern2.36895619
17MP0008569_lethality_at_weaning2.34461828
18MP0002736_abnormal_nociception_after2.32021544
19MP0002822_catalepsy2.16942445
20MP0002067_abnormal_sensory_capabilities2.05067418
21MP0003879_abnormal_hair_cell2.04324883
22MP0001970_abnormal_pain_threshold2.01782718
23MP0000778_abnormal_nervous_system1.97788833
24MP0002733_abnormal_thermal_nociception1.93231121
25MP0001440_abnormal_grooming_behavior1.91833295
26MP0001984_abnormal_olfaction1.79703955
27MP0003787_abnormal_imprinting1.79516924
28MP0004742_abnormal_vestibular_system1.78624680
29MP0003329_amyloid_beta_deposits1.77455923
30MP0004811_abnormal_neuron_physiology1.73402871
31MP0006276_abnormal_autonomic_nervous1.67916807
32MP0002557_abnormal_social/conspecific_i1.67665538
33MP0005386_behavior/neurological_phenoty1.66899765
34MP0004924_abnormal_behavior1.66899765
35MP0003122_maternal_imprinting1.53021672
36MP0002184_abnormal_innervation1.51877352
37MP0002066_abnormal_motor_capabilities/c1.51807835
38MP0002882_abnormal_neuron_morphology1.50815766
39MP0010386_abnormal_urinary_bladder1.50676325
40MP0003633_abnormal_nervous_system1.47250541
41MP0005646_abnormal_pituitary_gland1.45466326
42MP0000955_abnormal_spinal_cord1.39420235
43MP0001905_abnormal_dopamine_level1.30989766
44MP0004885_abnormal_endolymph1.30745157
45MP0001177_atelectasis1.28934051
46MP0003631_nervous_system_phenotype1.23690353
47MP0001529_abnormal_vocalization1.20435731
48MP0002152_abnormal_brain_morphology1.18758680
49MP0000569_abnormal_digit_pigmentation1.17601582
50MP0001502_abnormal_circadian_rhythm1.17248539
51MP0000920_abnormal_myelination1.17026239
52MP0002638_abnormal_pupillary_reflex1.15165972
53MP0003690_abnormal_glial_cell1.03581129
54MP0002229_neurodegeneration1.01436328
55MP0008874_decreased_physiological_sensi0.97727757
56MP0009780_abnormal_chondrocyte_physiolo0.95111834
57MP0003123_paternal_imprinting0.93529566
58MP0005623_abnormal_meninges_morphology0.92242744
59MP0001963_abnormal_hearing_physiology0.91212264
60MP0005551_abnormal_eye_electrophysiolog0.89640978
61MP0001485_abnormal_pinna_reflex0.84765326
62MP0003634_abnormal_glial_cell0.84060007
63MP0003632_abnormal_nervous_system0.81491144
64MP0002752_abnormal_somatic_nervous0.81297122
65MP0004142_abnormal_muscle_tone0.81119472
66MP0001188_hyperpigmentation0.80162222
67MP0002909_abnormal_adrenal_gland0.77017877
68MP0002069_abnormal_eating/drinking_beha0.76380516
69MP0003121_genomic_imprinting0.75539214
70MP0008872_abnormal_physiological_respon0.74411762
71MP0008877_abnormal_DNA_methylation0.71320394
72MP0003137_abnormal_impulse_conducting0.71286547
73MP0000566_synostosis0.70828187
74MP0000604_amyloidosis0.70664560
75MP0004147_increased_porphyrin_level0.68777007
76MP0003861_abnormal_nervous_system0.65784651
77MP0001299_abnormal_eye_distance/0.65581154
78MP0000026_abnormal_inner_ear0.65236641
79MP0001346_abnormal_lacrimal_gland0.62983579
80MP0010769_abnormal_survival0.61036399
81MP0010770_preweaning_lethality0.59754723
82MP0002082_postnatal_lethality0.59754723
83MP0005535_abnormal_body_temperature0.58356176
84MP0010768_mortality/aging0.57654819
85MP0000631_abnormal_neuroendocrine_gland0.57391076
86MP0004085_abnormal_heartbeat0.55720926
87MP0003938_abnormal_ear_development0.53072077
88MP0005187_abnormal_penis_morphology0.52579806
89MP0005394_taste/olfaction_phenotype0.51296775
90MP0005499_abnormal_olfactory_system0.51296775
91MP0001986_abnormal_taste_sensitivity0.51149704
92MP0003956_abnormal_body_size0.50809109
93MP0005167_abnormal_blood-brain_barrier0.49667784
94MP0001943_abnormal_respiration0.49402525
95MP0002102_abnormal_ear_morphology0.49145392
96MP0004215_abnormal_myocardial_fiber0.48345914
97MP0005645_abnormal_hypothalamus_physiol0.47834467
98MP0003283_abnormal_digestive_organ0.45420924
99MP0000579_abnormal_nail_morphology0.42790363
100MP0006292_abnormal_olfactory_placode0.40828787

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.95090177
2Myokymia (HP:0002411)8.14267340
3Febrile seizures (HP:0002373)7.44597455
4Atonic seizures (HP:0010819)7.41934643
5Focal seizures (HP:0007359)6.77675500
6Action tremor (HP:0002345)6.34593932
7Epileptic encephalopathy (HP:0200134)6.05972564
8Absence seizures (HP:0002121)5.04930497
9Progressive cerebellar ataxia (HP:0002073)4.69344094
10Dialeptic seizures (HP:0011146)4.61887305
11Generalized tonic-clonic seizures (HP:0002069)4.49526426
12Supranuclear gaze palsy (HP:0000605)3.94111663
13Impaired vibration sensation in the lower limbs (HP:0002166)3.90971267
14Abnormality of binocular vision (HP:0011514)3.82452402
15Diplopia (HP:0000651)3.82452402
16Truncal ataxia (HP:0002078)3.77340540
17Limb dystonia (HP:0002451)3.66382241
18Ankle clonus (HP:0011448)3.59316338
19Dysmetria (HP:0001310)3.45494274
20Dysdiadochokinesis (HP:0002075)3.43443396
21Scanning speech (HP:0002168)3.42959389
22Spastic gait (HP:0002064)3.40621525
23Broad-based gait (HP:0002136)3.37351350
24Intention tremor (HP:0002080)3.29558233
25Abnormal eating behavior (HP:0100738)3.26001086
26Mutism (HP:0002300)3.22579095
27Torticollis (HP:0000473)3.20051291
28Status epilepticus (HP:0002133)3.12709536
29Gaze-evoked nystagmus (HP:0000640)3.12137453
30Epileptiform EEG discharges (HP:0011182)3.04094808
31Urinary bladder sphincter dysfunction (HP:0002839)3.03797437
32Postural instability (HP:0002172)2.98362751
33Neurofibrillary tangles (HP:0002185)2.96773369
34Abnormality of the corticospinal tract (HP:0002492)2.95866480
35Urinary urgency (HP:0000012)2.94895323
36Amblyopia (HP:0000646)2.92623521
37Hemiplegia (HP:0002301)2.92591200
38Focal dystonia (HP:0004373)2.92014103
39Papilledema (HP:0001085)2.86361334
40Visual hallucinations (HP:0002367)2.84869616
41Poor eye contact (HP:0000817)2.81440591
42Drooling (HP:0002307)2.76201353
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73621906
44Degeneration of the lateral corticospinal tracts (HP:0002314)2.73621906
45Hemiparesis (HP:0001269)2.71181992
46Hyperventilation (HP:0002883)2.70253117
47EEG with generalized epileptiform discharges (HP:0011198)2.67554512
48Depression (HP:0000716)2.66084509
49Excessive salivation (HP:0003781)2.54995068
50Lower limb muscle weakness (HP:0007340)2.53410466
51Impaired smooth pursuit (HP:0007772)2.53164741
52Dysmetric saccades (HP:0000641)2.52746850
53Impaired vibratory sensation (HP:0002495)2.50842834
54Polyphagia (HP:0002591)2.46665161
55Delusions (HP:0000746)2.44850197
56Abnormality of the lower motor neuron (HP:0002366)2.44188682
57Craniofacial dystonia (HP:0012179)2.43204746
58Hypsarrhythmia (HP:0002521)2.41169103
59Anxiety (HP:0000739)2.41124878
60Akinesia (HP:0002304)2.38659945
61Impaired social interactions (HP:0000735)2.37986985
62Abnormal social behavior (HP:0012433)2.37986985
63Cerebral inclusion bodies (HP:0100314)2.36821335
64Annular pancreas (HP:0001734)2.36158479
65Bradykinesia (HP:0002067)2.31141131
66Abnormality of ocular smooth pursuit (HP:0000617)2.24832017
67Sleep apnea (HP:0010535)2.23937405
68Neuronal loss in central nervous system (HP:0002529)2.22436882
69Cerebral hypomyelination (HP:0006808)2.18395733
70Morphological abnormality of the pyramidal tract (HP:0002062)2.16535180
71Obstructive sleep apnea (HP:0002870)2.12772556
72Tetraplegia (HP:0002445)2.12329215
73Postural tremor (HP:0002174)2.08645058
74Gait ataxia (HP:0002066)2.07890254
75Absent speech (HP:0001344)2.05394536
76Clonus (HP:0002169)2.03114371
77Incomplete penetrance (HP:0003829)2.01446020
78Split foot (HP:0001839)1.98884099
79Apathy (HP:0000741)1.97650523
80Abnormality of saccadic eye movements (HP:0000570)1.92093677
81Insomnia (HP:0100785)1.87196521
82Spastic tetraplegia (HP:0002510)1.87059942
83Stereotypic behavior (HP:0000733)1.84752533
84Esotropia (HP:0000565)1.83843841
85Megalencephaly (HP:0001355)1.81554198
86Diminished motivation (HP:0000745)1.79434361
87Amyotrophic lateral sclerosis (HP:0007354)1.76101918
88Rigidity (HP:0002063)1.73850745
89Heterochromia iridis (HP:0001100)1.69777930
90Aplasia involving bones of the extremities (HP:0009825)1.68014596
91Aplasia involving bones of the upper limbs (HP:0009823)1.68014596
92Aplasia of the phalanges of the hand (HP:0009802)1.68014596
93Inability to walk (HP:0002540)1.67962433
94Generalized myoclonic seizures (HP:0002123)1.65781514
95Hammertoe (HP:0001765)1.65230367
96Peripheral hypomyelination (HP:0007182)1.64398004
97Rapidly progressive (HP:0003678)1.64094471
98Memory impairment (HP:0002354)1.63089754
99Limb ataxia (HP:0002070)1.60363345
100Hypoplasia of the corpus callosum (HP:0002079)1.57397123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.68759933
2MARK14.63992290
3NTRK34.08756618
4CASK3.38241434
5PAK63.17848926
6DAPK23.12784138
7MAP3K92.70354076
8NTRK22.62642126
9MINK12.27635164
10NTRK12.22108988
11UHMK12.12398668
12CAMKK12.05309764
13MAPK131.89767792
14PLK21.88797336
15GRK51.83347051
16SIK21.82374189
17LATS21.79672553
18PRKD31.69864222
19PINK11.66948999
20CDK51.61869484
21PRKCG1.55494619
22CDK191.51548237
23CAMKK21.42568017
24MAP3K41.41240050
25ARAF1.41036028
26DAPK11.37896222
27MAP3K121.26624512
28CAMK2B1.21257218
29CAMK11.18836996
30TNIK1.18790543
31CAMK2A1.15515065
32CDK151.11618923
33CDK181.10732773
34PHKG11.09665446
35PHKG21.09665446
36PAK31.09363542
37MAP2K71.08838642
38RIPK41.06086037
39CDK141.04834464
40CDK11A1.01605865
41CSNK1G21.01456729
42TYRO31.01415202
43PRKCH0.98635953
44SGK2230.98616026
45SGK4940.98616026
46KSR20.98493879
47KSR10.89602216
48CCNB10.87492709
49DYRK1A0.85549746
50PNCK0.85152121
51MAP2K40.79222081
52LIMK10.75682656
53STK110.70679036
54SGK10.70414905
55OXSR10.70322523
56STK380.69988457
57SGK20.68521666
58MARK20.66934779
59CAMK40.63095717
60CAMK2G0.62196023
61DYRK20.62194182
62TESK10.61980832
63PKN10.61519874
64PRKCE0.60833141
65ALK0.58876092
66NEK60.58009944
67PRKCZ0.57047262
68MAPK120.56716806
69ROCK20.56307580
70RPS6KA30.54606026
71MAPK100.53905904
72CAMK1G0.51164924
73BRSK10.50919391
74RAF10.50236030
75PDK10.50069756
76DAPK30.49929839
77FYN0.49562032
78MAP4K20.48552691
79BCR0.46608874
80PRKG10.46071184
81SGK30.45610922
82CSNK1G30.45417473
83EPHB20.44740196
84MAP3K130.44186688
85CSNK1A1L0.43871458
86ADRBK20.43425515
87RIPK10.43331092
88MAP3K110.42675081
89BMPR20.40817669
90CAMK2D0.38752862
91PRKCA0.37215715
92BRAF0.35228106
93ROCK10.34272437
94WNK10.34062960
95MOS0.33681929
96TAOK10.33313958
97WNK30.32988032
98CSNK1D0.32317877
99PRKACA0.31219401
100CAMK1D0.31000166

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.73717184
2Synaptic vesicle cycle_Homo sapiens_hsa047213.47483350
3GABAergic synapse_Homo sapiens_hsa047273.20781771
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.09640288
5Morphine addiction_Homo sapiens_hsa050322.98448109
6Long-term potentiation_Homo sapiens_hsa047202.93582072
7Circadian entrainment_Homo sapiens_hsa047132.91748015
8Glutamatergic synapse_Homo sapiens_hsa047242.90373111
9Amphetamine addiction_Homo sapiens_hsa050312.78513867
10Dopaminergic synapse_Homo sapiens_hsa047282.43340823
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38959950
12Insulin secretion_Homo sapiens_hsa049112.25484739
13Gastric acid secretion_Homo sapiens_hsa049712.08801000
14Cholinergic synapse_Homo sapiens_hsa047252.04122975
15Cocaine addiction_Homo sapiens_hsa050302.03328936
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.99376425
17Salivary secretion_Homo sapiens_hsa049701.89357706
18Long-term depression_Homo sapiens_hsa047301.82487348
19Taste transduction_Homo sapiens_hsa047421.76151987
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75062647
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.59046774
22Calcium signaling pathway_Homo sapiens_hsa040201.56545326
23Oxytocin signaling pathway_Homo sapiens_hsa049211.55055403
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50567492
25Renin secretion_Homo sapiens_hsa049241.45834332
26Serotonergic synapse_Homo sapiens_hsa047261.40467502
27cAMP signaling pathway_Homo sapiens_hsa040241.39170810
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36625087
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.35237392
30Gap junction_Homo sapiens_hsa045401.34992217
31Cardiac muscle contraction_Homo sapiens_hsa042601.24638771
32Olfactory transduction_Homo sapiens_hsa047401.20485846
33Estrogen signaling pathway_Homo sapiens_hsa049151.19733377
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15923811
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12767662
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12567769
37Pancreatic secretion_Homo sapiens_hsa049721.06535439
38GnRH signaling pathway_Homo sapiens_hsa049121.04917260
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01537895
40Oocyte meiosis_Homo sapiens_hsa041141.01135310
41Glioma_Homo sapiens_hsa052141.00701972
42Melanogenesis_Homo sapiens_hsa049160.99927992
43Vitamin B6 metabolism_Homo sapiens_hsa007500.97983215
44Axon guidance_Homo sapiens_hsa043600.95231119
45Collecting duct acid secretion_Homo sapiens_hsa049660.94513566
46Thyroid hormone synthesis_Homo sapiens_hsa049180.92694297
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.83216834
48ErbB signaling pathway_Homo sapiens_hsa040120.83215621
49Nitrogen metabolism_Homo sapiens_hsa009100.78824766
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78791565
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77101464
52Phototransduction_Homo sapiens_hsa047440.76105278
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.73920027
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.72525085
55Type II diabetes mellitus_Homo sapiens_hsa049300.72250724
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71260134
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70185087
58Vibrio cholerae infection_Homo sapiens_hsa051100.67513341
59Alzheimers disease_Homo sapiens_hsa050100.66005645
60Dilated cardiomyopathy_Homo sapiens_hsa054140.63711988
61Ras signaling pathway_Homo sapiens_hsa040140.63568815
62MAPK signaling pathway_Homo sapiens_hsa040100.60415539
63Rap1 signaling pathway_Homo sapiens_hsa040150.59091774
64Prion diseases_Homo sapiens_hsa050200.55460966
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50255030
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49555302
67Glucagon signaling pathway_Homo sapiens_hsa049220.49471027
68Circadian rhythm_Homo sapiens_hsa047100.47878377
69Bile secretion_Homo sapiens_hsa049760.47416973
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.47413955
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45694454
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44946390
73Dorso-ventral axis formation_Homo sapiens_hsa043200.42363084
74Alcoholism_Homo sapiens_hsa050340.41925852
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41859109
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.41643402
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41624031
78Choline metabolism in cancer_Homo sapiens_hsa052310.41513848
79Inositol phosphate metabolism_Homo sapiens_hsa005620.40401741
80Wnt signaling pathway_Homo sapiens_hsa043100.39182405
81VEGF signaling pathway_Homo sapiens_hsa043700.37975381
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36558783
83Endocytosis_Homo sapiens_hsa041440.34924036
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29881672
85Hippo signaling pathway_Homo sapiens_hsa043900.28325423
86Oxidative phosphorylation_Homo sapiens_hsa001900.26279909
87Tight junction_Homo sapiens_hsa045300.25894580
88mTOR signaling pathway_Homo sapiens_hsa041500.25442253
89Parkinsons disease_Homo sapiens_hsa050120.23738002
90Fatty acid biosynthesis_Homo sapiens_hsa000610.23040584
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21885119
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18488117
93Mineral absorption_Homo sapiens_hsa049780.17598041
94Arginine biosynthesis_Homo sapiens_hsa002200.17209104
95Arginine and proline metabolism_Homo sapiens_hsa003300.12353035
96Regulation of autophagy_Homo sapiens_hsa041400.12303881
97AMPK signaling pathway_Homo sapiens_hsa041520.11898715
98Protein digestion and absorption_Homo sapiens_hsa049740.11155518
99Hedgehog signaling pathway_Homo sapiens_hsa043400.10526160
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09925605

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