C12ORF49

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to microtubule (GO:0035372)6.72989866
2regulation of hippo signaling (GO:0035330)4.90104931
3embryonic foregut morphogenesis (GO:0048617)3.98853360
4protein localization to microtubule cytoskeleton (GO:0072698)3.94324488
5protein localization to kinetochore (GO:0034501)3.89087492
6dorsal/ventral axis specification (GO:0009950)3.73780627
7microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.73363813
8kidney morphogenesis (GO:0060993)3.69587303
9thyroid hormone generation (GO:0006590)3.65674497
10postsynaptic membrane organization (GO:0001941)3.63981677
11presynaptic membrane assembly (GO:0097105)3.61396895
12protein localization to cytoskeleton (GO:0044380)3.56366556
13pyrimidine nucleobase catabolic process (GO:0006208)3.48882341
14attachment of spindle microtubules to kinetochore (GO:0008608)3.38740845
15protein localization to chromosome, centromeric region (GO:0071459)3.34280166
16gonadal mesoderm development (GO:0007506)3.30157171
17regulation of gene silencing by RNA (GO:0060966)3.29656037
18regulation of posttranscriptional gene silencing (GO:0060147)3.29656037
19regulation of gene silencing by miRNA (GO:0060964)3.29656037
20ectodermal placode formation (GO:0060788)3.25659469
21peristalsis (GO:0030432)3.23826897
22cell migration in hindbrain (GO:0021535)3.16250872
23mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.14680158
24ear development (GO:0043583)3.11640289
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.09032259
26regulation of translation, ncRNA-mediated (GO:0045974)3.09032259
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.09032259
28limb bud formation (GO:0060174)2.98578331
29thyroid hormone metabolic process (GO:0042403)2.97669104
30presynaptic membrane organization (GO:0097090)2.97250296
31cytoplasmic mRNA processing body assembly (GO:0033962)2.96426120
32apical protein localization (GO:0045176)2.95732198
33atrial cardiac muscle cell action potential (GO:0086014)2.94957780
34nerve growth factor signaling pathway (GO:0038180)2.88655860
35auditory behavior (GO:0031223)2.82357337
36regulation of synapse structural plasticity (GO:0051823)2.78074591
37synapse assembly (GO:0007416)2.77660346
38establishment or maintenance of monopolar cell polarity (GO:0061339)2.76885065
39establishment of monopolar cell polarity (GO:0061162)2.76885065
40axonal fasciculation (GO:0007413)2.71429699
41ectoderm development (GO:0007398)2.71204001
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69608926
43establishment of apical/basal cell polarity (GO:0035089)2.68067509
44neuron recognition (GO:0008038)2.66813406
45surfactant homeostasis (GO:0043129)2.63448998
46regulation of axon extension involved in axon guidance (GO:0048841)2.62515430
47gap junction assembly (GO:0016264)2.62403453
48nephron tubule formation (GO:0072079)2.61275960
49paraxial mesoderm development (GO:0048339)2.59485597
50establishment of nucleus localization (GO:0040023)2.59480928
51regulation of axon guidance (GO:1902667)2.58233323
52myotube differentiation (GO:0014902)2.57059561
53response to lipoprotein particle (GO:0055094)2.56062917
54nucleobase catabolic process (GO:0046113)2.54702739
55establishment of planar polarity (GO:0001736)2.54259114
56establishment of tissue polarity (GO:0007164)2.54259114
57response to auditory stimulus (GO:0010996)2.52091853
58protein localization to endosome (GO:0036010)2.51985772
59glomerular visceral epithelial cell development (GO:0072015)2.51661243
60glial cell proliferation (GO:0014009)2.51591511
61chemical homeostasis within a tissue (GO:0048875)2.49757308
62mating behavior (GO:0007617)2.49519699
63notochord development (GO:0030903)2.49012290
64dendrite morphogenesis (GO:0048813)2.48803275
65regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.48382535
66neuron cell-cell adhesion (GO:0007158)2.46937192
67response to nerve growth factor (GO:1990089)2.46859575
68cellular response to nerve growth factor stimulus (GO:1990090)2.46859575
69axon extension involved in axon guidance (GO:0048846)2.46039826
70neuron projection extension involved in neuron projection guidance (GO:1902284)2.46039826
71calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.45804174
72regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.45747244
73epithelial tube branching involved in lung morphogenesis (GO:0060441)2.42400726
74Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.39462521
75polarized epithelial cell differentiation (GO:0030859)2.38515686
76regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36413259
77planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36364903
78axon extension (GO:0048675)2.35852648
79intestinal epithelial cell development (GO:0060576)2.34715655
80cell migration involved in gastrulation (GO:0042074)2.33479007
81layer formation in cerebral cortex (GO:0021819)2.33027360
82organ growth (GO:0035265)2.32546744
83asymmetric protein localization (GO:0008105)2.28455717
84negative regulation of activin receptor signaling pathway (GO:0032926)2.28303714
85sulfate transport (GO:0008272)2.28147989
86vocalization behavior (GO:0071625)2.27654340
87mesenchymal to epithelial transition (GO:0060231)2.25723218
88regulation of establishment of planar polarity (GO:0090175)2.22577982
89morphogenesis of an epithelial sheet (GO:0002011)2.22175445
90negative regulation of organelle assembly (GO:1902116)2.22100098
91regulation of growth hormone secretion (GO:0060123)2.22074507
92lateral sprouting from an epithelium (GO:0060601)2.21739040
93positive regulation of neuroblast proliferation (GO:0002052)2.21627503
94cytoskeletal anchoring at plasma membrane (GO:0007016)2.18002237
95spinal cord development (GO:0021510)2.16928666
96sympathetic nervous system development (GO:0048485)2.16792441
97mechanosensory behavior (GO:0007638)2.16618257
98glomerular epithelial cell development (GO:0072310)2.15911318
99artery development (GO:0060840)2.15680429
100inner ear receptor cell development (GO:0060119)2.15250619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.10617524
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.98433983
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87290381
4EZH2_22144423_ChIP-Seq_EOC_Human2.86411347
5ZNF217_24962896_ChIP-Seq_MCF-7_Human2.69867816
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65132579
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65130771
8* AHR_22903824_ChIP-Seq_MCF-7_Human2.53987105
9* ESR1_21235772_ChIP-Seq_MCF-7_Human2.46403376
10* ARNT_22903824_ChIP-Seq_MCF-7_Human2.20040123
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07800789
12GBX2_23144817_ChIP-Seq_PC3_Human2.06594528
13ZNF274_21170338_ChIP-Seq_K562_Hela2.05561206
14AR_21572438_ChIP-Seq_LNCaP_Human1.99050378
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92609049
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89601680
17GATA1_22025678_ChIP-Seq_K562_Human1.84998608
18SMAD3_21741376_ChIP-Seq_EPCs_Human1.84473371
19RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82512121
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81455573
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.79233708
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77873988
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.74813341
24SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72989240
25STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.68068441
26SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66901131
27RNF2_27304074_Chip-Seq_ESCs_Mouse1.65793257
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.63994059
29TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.62485912
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.61355738
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.58819176
32ISL1_27105846_Chip-Seq_CPCs_Mouse1.55699081
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48852000
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47835200
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46998449
36RING1B_27294783_Chip-Seq_NPCs_Mouse1.45064600
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45059902
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43454499
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43131761
40YAP1_20516196_ChIP-Seq_MESCs_Mouse1.42911180
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41819363
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39454016
43REST_21632747_ChIP-Seq_MESCs_Mouse1.38517318
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38285282
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38285282
46SMAD3_21741376_ChIP-Seq_HESCs_Human1.37520498
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36578657
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36578657
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34910460
50RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.33510726
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33509548
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.31837359
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30934588
54TBX3_20139965_ChIP-Seq_MESCs_Mouse1.28180112
55P300_19829295_ChIP-Seq_ESCs_Human1.28105511
56SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27626509
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27568616
58TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26920657
59* SMAD4_21741376_ChIP-Seq_HESCs_Human1.26855997
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23484293
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21979278
62* STAT3_23295773_ChIP-Seq_U87_Human1.21907238
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.20983832
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19759380
65TP53_16413492_ChIP-PET_HCT116_Human1.19683652
66SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18986284
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18451739
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17141382
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16059008
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15959954
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.15818582
72FOXM1_23109430_ChIP-Seq_U2OS_Human1.14944357
73RNF2_27304074_Chip-Seq_NSC_Mouse1.14199261
74SMAD4_21799915_ChIP-Seq_A2780_Human1.14031129
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.13285636
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13125152
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.12677686
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.11460607
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11110739
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10707240
81ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10317050
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10255824
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09448186
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09040293
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.07866965
86AR_19668381_ChIP-Seq_PC3_Human1.07405770
87POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.06525424
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.06364045
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05408843
90TCF4_23295773_ChIP-Seq_U87_Human1.04501667
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04451105
92TP53_18474530_ChIP-ChIP_U2OS_Human1.03524080
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03226173
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03165889
95RXR_22108803_ChIP-Seq_LS180_Human1.02066433
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01863195
97AR_25329375_ChIP-Seq_VCAP_Human1.01835452
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.01396808
99PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.01161943
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00322043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.61079701
2MP0000537_abnormal_urethra_morphology2.74255831
3MP0003283_abnormal_digestive_organ2.59337229
4MP0005257_abnormal_intraocular_pressure2.55731441
5MP0003136_yellow_coat_color2.50137425
6MP0003890_abnormal_embryonic-extraembry2.38507592
7MP0000566_synostosis2.28909564
8MP0010678_abnormal_skin_adnexa2.24046559
9MP0000383_abnormal_hair_follicle2.22224110
10MP0005409_darkened_coat_color2.20217219
11MP0000569_abnormal_digit_pigmentation2.10864204
12MP0010234_abnormal_vibrissa_follicle2.09365124
13MP0000778_abnormal_nervous_system2.06552126
14MP0004782_abnormal_surfactant_physiolog1.97899377
15MP0002254_reproductive_system_inflammat1.88135264
16MP0005171_absent_coat_pigmentation1.82683902
17MP0003329_amyloid_beta_deposits1.74596031
18MP0002877_abnormal_melanocyte_morpholog1.70343974
19MP0009840_abnormal_foam_cell1.65512564
20MP0002751_abnormal_autonomic_nervous1.61098584
21MP0005076_abnormal_cell_differentiation1.59757214
22MP0003937_abnormal_limbs/digits/tail_de1.50376501
23MP0009053_abnormal_anal_canal1.49256354
24MP0001177_atelectasis1.47604601
25MP0000534_abnormal_ureter_morphology1.46822292
26MP0003632_abnormal_nervous_system1.45792646
27MP0002089_abnormal_postnatal_growth/wei1.44999442
28MP0004270_analgesia1.42204375
29MP0005167_abnormal_blood-brain_barrier1.41751832
30MP0003119_abnormal_digestive_system1.39534973
31MP0004885_abnormal_endolymph1.36212080
32MP0002098_abnormal_vibrissa_morphology1.36197577
33MP0001849_ear_inflammation1.34620904
34MP0002909_abnormal_adrenal_gland1.31121924
35MP0000681_abnormal_thyroid_gland1.29850523
36MP0003861_abnormal_nervous_system1.29686059
37MP0004742_abnormal_vestibular_system1.28782316
38MP0000428_abnormal_craniofacial_morphol1.27768713
39MP0003942_abnormal_urinary_system1.26919422
40MP0006054_spinal_hemorrhage1.25589255
41MP0004133_heterotaxia1.25083592
42MP0001486_abnormal_startle_reflex1.24643596
43MP0002735_abnormal_chemical_nociception1.21915006
44MP0010030_abnormal_orbit_morphology1.20661450
45MP0003634_abnormal_glial_cell1.20110907
46MP0002697_abnormal_eye_size1.19315849
47MP0002064_seizures1.14938228
48MP0001348_abnormal_lacrimal_gland1.14627173
49MP0005408_hypopigmentation1.13903894
50MP0003091_abnormal_cell_migration1.10274092
51MP0004859_abnormal_synaptic_plasticity1.10235458
52MP0000631_abnormal_neuroendocrine_gland1.09333832
53MP0002063_abnormal_learning/memory/cond1.09172156
54MP0002184_abnormal_innervation1.09090186
55MP0009046_muscle_twitch1.08634787
56MP0002152_abnormal_brain_morphology1.07579541
57MP0001501_abnormal_sleep_pattern1.07302143
58MP0000955_abnormal_spinal_cord1.04954455
59MP0002572_abnormal_emotion/affect_behav1.04417562
60MP0002557_abnormal_social/conspecific_i1.04309299
61MP0004233_abnormal_muscle_weight1.03715230
62MP0004264_abnormal_extraembryonic_tissu1.03689857
63MP0000427_abnormal_hair_cycle1.02611325
64MP0000604_amyloidosis1.01811838
65MP0003635_abnormal_synaptic_transmissio1.00044931
66MP0002092_abnormal_eye_morphology0.99856758
67MP0002084_abnormal_developmental_patter0.98619557
68MP0005197_abnormal_uvea_morphology0.98429270
69MP0002733_abnormal_thermal_nociception0.98287878
70MP0000647_abnormal_sebaceous_gland0.97361608
71MP0000015_abnormal_ear_pigmentation0.94564680
72MP0003115_abnormal_respiratory_system0.93954156
73MP0002734_abnormal_mechanical_nocicepti0.92563064
74MP0005248_abnormal_Harderian_gland0.92187014
75MP0002882_abnormal_neuron_morphology0.91748179
76MP0000432_abnormal_head_morphology0.89441667
77MP0005386_behavior/neurological_phenoty0.88107264
78MP0004924_abnormal_behavior0.88107264
79MP0010368_abnormal_lymphatic_system0.88085049
80MP0000371_diluted_coat_color0.87806087
81MP0003938_abnormal_ear_development0.87720512
82MP0004272_abnormal_basement_membrane0.87383073
83MP0005423_abnormal_somatic_nervous0.85571736
84MP0003935_abnormal_craniofacial_develop0.85442245
85MP0009745_abnormal_behavioral_response0.85172880
86MP0001529_abnormal_vocalization0.84997186
87MP0005391_vision/eye_phenotype0.82394770
88MP0002938_white_spotting0.81023824
89MP0001324_abnormal_eye_pigmentation0.81020504
90MP0002234_abnormal_pharynx_morphology0.80890662
91MP0000462_abnormal_digestive_system0.80327577
92MP0000026_abnormal_inner_ear0.79478749
93MP0004043_abnormal_pH_regulation0.79358097
94MP0002653_abnormal_ependyma_morphology0.78830704
95MP0000377_abnormal_hair_follicle0.77988409
96MP0002085_abnormal_embryonic_tissue0.77959815
97MP0003755_abnormal_palate_morphology0.77868646
98MP0001286_abnormal_eye_development0.77684879
99MP0002090_abnormal_vision0.77178894
100MP0002111_abnormal_tail_morphology0.76080746

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.17811613
2Birth length less than 3rd percentile (HP:0003561)3.02762597
3Neurofibrillary tangles (HP:0002185)2.97472375
4Type II lissencephaly (HP:0007260)2.76466807
5Overriding aorta (HP:0002623)2.56155527
6Thyroid-stimulating hormone excess (HP:0002925)2.49044561
7Cutaneous finger syndactyly (HP:0010554)2.48179062
8Aplasia/Hypoplasia of the sternum (HP:0006714)2.44677146
9Hyperacusis (HP:0010780)2.41514878
10Renovascular hypertension (HP:0100817)2.41428700
11Lissencephaly (HP:0001339)2.39997752
12Aplasia involving bones of the upper limbs (HP:0009823)2.36706989
13Aplasia of the phalanges of the hand (HP:0009802)2.36706989
14Aplasia involving bones of the extremities (HP:0009825)2.36706989
15Bronchomalacia (HP:0002780)2.33799489
16Cerebellar dysplasia (HP:0007033)2.24728272
17Breast hypoplasia (HP:0003187)2.22600017
18Cerebral inclusion bodies (HP:0100314)2.21364503
19Interstitial pulmonary disease (HP:0006530)2.18691418
20Midline defect of the nose (HP:0004122)2.16632442
21Goiter (HP:0000853)2.15121318
22Partial agenesis of the corpus callosum (HP:0001338)2.08662442
23Elfin facies (HP:0004428)2.08576111
24Protruding tongue (HP:0010808)2.07121364
25Patellar aplasia (HP:0006443)2.06407900
26Large eyes (HP:0001090)2.06007316
27Cutaneous syndactyly (HP:0012725)2.05700379
28Chronic hepatic failure (HP:0100626)2.04286581
29Inability to walk (HP:0002540)2.03314106
30Progressive inability to walk (HP:0002505)2.01206598
31Megalencephaly (HP:0001355)1.99684357
32Pheochromocytoma (HP:0002666)1.98860698
33Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96866836
34Hypoplasia of the brainstem (HP:0002365)1.96866836
35Germ cell neoplasia (HP:0100728)1.96133659
36Hypopigmentation of the fundus (HP:0007894)1.95684441
37Drooling (HP:0002307)1.90622199
38Blue irides (HP:0000635)1.90216407
39Increased cerebral lipofuscin (HP:0011813)1.87068134
40Spastic tetraparesis (HP:0001285)1.84618749
41Aplasia/Hypoplasia of the patella (HP:0006498)1.83134490
42Anterior segment dysgenesis (HP:0007700)1.78190484
43Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.76635651
44Large for gestational age (HP:0001520)1.76305787
45Transitional cell carcinoma of the bladder (HP:0006740)1.74614883
46Morphological abnormality of the middle ear (HP:0008609)1.74233219
47Buphthalmos (HP:0000557)1.74033303
48Increased neuronal autofluorescent lipopigment (HP:0002074)1.72959633
49Preaxial foot polydactyly (HP:0001841)1.71698196
50Limb dystonia (HP:0002451)1.71277260
51Small epiphyses (HP:0010585)1.68791374
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.68622112
53Non-midline cleft lip (HP:0100335)1.67789841
54Renal duplication (HP:0000075)1.67509441
55Concave nail (HP:0001598)1.67369655
56Depressed nasal tip (HP:0000437)1.67353286
57Excessive salivation (HP:0003781)1.66965635
58Anal stenosis (HP:0002025)1.66500350
59Arnold-Chiari malformation (HP:0002308)1.65812882
60Absent eyebrow (HP:0002223)1.63794437
61Heterotopia (HP:0002282)1.63366857
62Bilateral microphthalmos (HP:0007633)1.63215947
63Hypoplasia of the maxilla (HP:0000327)1.62240652
64Breast carcinoma (HP:0003002)1.62004914
65Scrotal hypoplasia (HP:0000046)1.61737204
66Abnormality of the fingertips (HP:0001211)1.61678679
67Bladder carcinoma (HP:0002862)1.60725216
68Bladder neoplasm (HP:0009725)1.60725216
69Abnormality of the vitreous humor (HP:0004327)1.60506747
70Tracheomalacia (HP:0002779)1.60227743
71Turricephaly (HP:0000262)1.59312650
72Leiomyosarcoma (HP:0100243)1.59245524
73Uterine leiomyosarcoma (HP:0002891)1.59245524
74Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.58245307
75Macroorchidism (HP:0000053)1.58218426
76Long foot (HP:0001833)1.57168904
77Long nose (HP:0003189)1.56652561
78Asymmetry of the thorax (HP:0001555)1.56398669
79Subacute progressive viral hepatitis (HP:0006572)1.55306666
80Congenital sensorineural hearing impairment (HP:0008527)1.54513415
81Tubulointerstitial fibrosis (HP:0005576)1.52359949
82Esophageal atresia (HP:0002032)1.52185467
83Abnormality of the distal phalanx of the thumb (HP:0009617)1.51460792
84Pachygyria (HP:0001302)1.49121101
85Generalized myoclonic seizures (HP:0002123)1.48987638
86Sporadic (HP:0003745)1.46779130
87Myelomeningocele (HP:0002475)1.46496501
88Clumsiness (HP:0002312)1.46034148
89Gastrointestinal carcinoma (HP:0002672)1.45460096
90Malignant gastrointestinal tract tumors (HP:0006749)1.45460096
91Megalocornea (HP:0000485)1.44980389
92Urinary bladder sphincter dysfunction (HP:0002839)1.44748040
93Coarse facial features (HP:0000280)1.42232188
94Renal cell carcinoma (HP:0005584)1.41790965
95Abnormality of liposaccharide metabolism (HP:0010968)1.41678124
96Abnormality of glycosphingolipid metabolism (HP:0004343)1.41678124
97Abnormality of glycolipid metabolism (HP:0010969)1.41678124
98High anterior hairline (HP:0009890)1.41060675
99Pancreatic cysts (HP:0001737)1.40714812
100Breast aplasia (HP:0100783)1.40435981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.42125389
2ACVR1B3.00743042
3BMPR1B2.86938134
4DAPK22.76348697
5MARK12.76105717
6MAP3K92.55855273
7CAMKK12.18357780
8MAP3K102.08593928
9LATS11.95447309
10TRIB31.84249848
11EPHA21.77847352
12EEF2K1.72933761
13ZAK1.72708816
14LATS21.72275787
15NTRK11.70971712
16MAP3K41.70870569
17MET1.65945922
18NTRK21.63679016
19FGFR21.62270080
20CAMK1D1.55729379
21STK38L1.53177650
22TGFBR11.53140932
23MKNK21.52566777
24MST1R1.51794275
25STK241.51453693
26PASK1.49850615
27ICK1.46029170
28TYRO31.44392205
29BCR1.40784604
30TAF11.35433484
31CSNK1G21.31964327
32CSNK1A1L1.29295887
33LMTK21.25391939
34CAMK1G1.21179403
35ERBB41.17765179
36DYRK21.17332307
37CSNK1G31.13554728
38CSNK1G11.11375957
39TLK11.11273547
40PAK61.08561459
41BRD41.07168715
42PDGFRA1.06417150
43SIK11.02144941
44MAP3K120.98834045
45CHUK0.96510688
46MAP2K70.94483003
47STK380.94083216
48PDGFRB0.91769260
49EPHB20.90617586
50MELK0.90432048
51KSR10.88063506
52YES10.83837595
53TRIM280.83702716
54CDK80.82839910
55NTRK30.76248278
56STK390.75196988
57NEK90.72056556
58CDK120.72050251
59NEK60.72030782
60WNK30.71387904
61SIK20.69909815
62CAMKK20.68699751
63RET0.65417583
64TSSK60.65403888
65PRKCZ0.64530207
66SGK4940.64481244
67SGK2230.64481244
68EPHA40.64418815
69STK30.62120508
70SGK30.61464712
71PRKCG0.61123266
72RPS6KA20.60029191
73RPS6KB10.59945268
74WEE10.59734712
75EIF2AK20.59206752
76SGK20.59085306
77PINK10.58946513
78FRK0.57817753
79PAK40.56276896
80MAP3K20.55277982
81IRAK20.52743280
82PKN20.52649770
83PNCK0.51104276
84CAMK40.50013396
85DYRK30.50007235
86NEK20.49992010
87CDK50.48764382
88WNK40.46954328
89CAMK2A0.46627848
90MAPK130.46453165
91MTOR0.46166984
92FGFR40.45685368
93PRKCI0.44606450
94RIPK10.44543660
95ERBB30.44057012
96CSNK1D0.42837970
97CAMK2B0.42740042
98MAP2K40.42660151
99PTK60.40925536
100PRKCE0.40238444

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41895303
2Selenocompound metabolism_Homo sapiens_hsa004502.30200238
3Hippo signaling pathway_Homo sapiens_hsa043902.12775037
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.12243680
5Thyroid hormone synthesis_Homo sapiens_hsa049181.93788133
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.93139062
7Nicotine addiction_Homo sapiens_hsa050331.91959535
8Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.83490246
9Axon guidance_Homo sapiens_hsa043601.79538736
10Lysosome_Homo sapiens_hsa041421.73933501
11Renal cell carcinoma_Homo sapiens_hsa052111.65026395
12TGF-beta signaling pathway_Homo sapiens_hsa043501.57108372
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49137205
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.47683088
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43879056
16Basal cell carcinoma_Homo sapiens_hsa052171.43313965
17Sphingolipid metabolism_Homo sapiens_hsa006001.42797984
18Endometrial cancer_Homo sapiens_hsa052131.40717566
19Dorso-ventral axis formation_Homo sapiens_hsa043201.38774720
20ErbB signaling pathway_Homo sapiens_hsa040121.37858470
21Adherens junction_Homo sapiens_hsa045201.36936352
22Bladder cancer_Homo sapiens_hsa052191.30549251
23Neurotrophin signaling pathway_Homo sapiens_hsa047221.28903436
24Tight junction_Homo sapiens_hsa045301.28194809
25Inositol phosphate metabolism_Homo sapiens_hsa005621.26164381
26MicroRNAs in cancer_Homo sapiens_hsa052061.24887565
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21879698
28Glutamatergic synapse_Homo sapiens_hsa047241.17293778
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.16035957
30Prolactin signaling pathway_Homo sapiens_hsa049171.14317600
31Dopaminergic synapse_Homo sapiens_hsa047281.13670460
32Cocaine addiction_Homo sapiens_hsa050301.12209623
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11200865
34Estrogen signaling pathway_Homo sapiens_hsa049151.10472555
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09966347
36Sphingolipid signaling pathway_Homo sapiens_hsa040711.09844160
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09329297
38Hedgehog signaling pathway_Homo sapiens_hsa043401.02885313
39ABC transporters_Homo sapiens_hsa020101.02831886
40Small cell lung cancer_Homo sapiens_hsa052221.02557559
41Proteoglycans in cancer_Homo sapiens_hsa052051.02192476
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01614655
43Rap1 signaling pathway_Homo sapiens_hsa040151.00168555
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.99897197
45Steroid biosynthesis_Homo sapiens_hsa001000.96916266
46Colorectal cancer_Homo sapiens_hsa052100.96807301
47Vibrio cholerae infection_Homo sapiens_hsa051100.95601669
48Thyroid cancer_Homo sapiens_hsa052160.93628223
49Melanoma_Homo sapiens_hsa052180.92630852
50Synaptic vesicle cycle_Homo sapiens_hsa047210.92594532
51Melanogenesis_Homo sapiens_hsa049160.89867233
52Morphine addiction_Homo sapiens_hsa050320.89838474
53Nitrogen metabolism_Homo sapiens_hsa009100.88711337
54Basal transcription factors_Homo sapiens_hsa030220.87834824
55Type II diabetes mellitus_Homo sapiens_hsa049300.87605555
56Pathways in cancer_Homo sapiens_hsa052000.86490307
57VEGF signaling pathway_Homo sapiens_hsa043700.86482423
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85313331
59GABAergic synapse_Homo sapiens_hsa047270.84848293
60Wnt signaling pathway_Homo sapiens_hsa043100.84833513
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82943137
62Ras signaling pathway_Homo sapiens_hsa040140.82747174
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82000605
64Chronic myeloid leukemia_Homo sapiens_hsa052200.81880592
65Cholinergic synapse_Homo sapiens_hsa047250.81845693
66mRNA surveillance pathway_Homo sapiens_hsa030150.81725881
67Alcoholism_Homo sapiens_hsa050340.81425921
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81366417
69Circadian entrainment_Homo sapiens_hsa047130.81344496
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81220817
71N-Glycan biosynthesis_Homo sapiens_hsa005100.80716622
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80320364
73Long-term depression_Homo sapiens_hsa047300.79759893
74Notch signaling pathway_Homo sapiens_hsa043300.79689902
75mTOR signaling pathway_Homo sapiens_hsa041500.79626088
76Gastric acid secretion_Homo sapiens_hsa049710.77834277
77Amphetamine addiction_Homo sapiens_hsa050310.77738301
78Prostate cancer_Homo sapiens_hsa052150.77044146
79PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76161630
80Focal adhesion_Homo sapiens_hsa045100.73402556
81Glioma_Homo sapiens_hsa052140.73210586
82Serotonergic synapse_Homo sapiens_hsa047260.72653180
83ECM-receptor interaction_Homo sapiens_hsa045120.72551306
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71610871
85FoxO signaling pathway_Homo sapiens_hsa040680.71146443
86Phototransduction_Homo sapiens_hsa047440.69389492
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69168737
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68056038
89Choline metabolism in cancer_Homo sapiens_hsa052310.65379289
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.63018528
91Gap junction_Homo sapiens_hsa045400.61489625
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.60063551
93Insulin secretion_Homo sapiens_hsa049110.60029664
94GnRH signaling pathway_Homo sapiens_hsa049120.59406770
95MAPK signaling pathway_Homo sapiens_hsa040100.58861078
96cAMP signaling pathway_Homo sapiens_hsa040240.56640692
97Taste transduction_Homo sapiens_hsa047420.56543266
98Other glycan degradation_Homo sapiens_hsa005110.55400008
99Endocytosis_Homo sapiens_hsa041440.53434236
100Apoptosis_Homo sapiens_hsa042100.52686843

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