ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.08478975
2	indolalkylamine metabolic process (GO:0006586)	4.40039629
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.30332337
4	response to pheromone (GO:0019236)	4.29009270
5	indole-containing compound catabolic process (GO:0042436)	4.11552849
6	indolalkylamine catabolic process (GO:0046218)	4.11552849
7	tryptophan catabolic process (GO:0006569)	4.11552849
8	kynurenine metabolic process (GO:0070189)	3.78927222
9	fucose catabolic process (GO:0019317)	3.77340238
10	L-fucose metabolic process (GO:0042354)	3.77340238
11	L-fucose catabolic process (GO:0042355)	3.77340238
12	tryptophan metabolic process (GO:0006568)	3.76911865
13	gamma-aminobutyric acid transport (GO:0015812)	3.75561193
14	detection of light stimulus involved in visual perception (GO:0050908)	3.71102918
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.71102918
16	cellular ketone body metabolic process (GO:0046950)	3.62488334
17	behavioral response to ethanol (GO:0048149)	3.56531549
18	epithelial cilium movement (GO:0003351)	3.51615116
19	indole-containing compound metabolic process (GO:0042430)	3.47173385
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.45177811
21	piRNA metabolic process (GO:0034587)	3.33542243
22	ketone body metabolic process (GO:1902224)	3.28165529
23	nonmotile primary cilium assembly (GO:0035058)	3.27011037
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.25739961
25	retinal cone cell development (GO:0046549)	3.23884276
26	reflex (GO:0060004)	3.21883609
27	photoreceptor cell maintenance (GO:0045494)	3.21495329
28	neural tube formation (GO:0001841)	3.20508909
29	water-soluble vitamin biosynthetic process (GO:0042364)	3.19925257
30	primary amino compound metabolic process (GO:1901160)	3.17785305
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.17014862
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.17014862
33	NADH dehydrogenase complex assembly (GO:0010257)	3.17014862
34	serotonin metabolic process (GO:0042428)	3.14848261
35	sulfation (GO:0051923)	3.13659557
36	protein polyglutamylation (GO:0018095)	3.10080839
37	cilium movement (GO:0003341)	3.07597698
38	auditory receptor cell stereocilium organization (GO:0060088)	3.05456437
39	reciprocal DNA recombination (GO:0035825)	3.03804130
40	reciprocal meiotic recombination (GO:0007131)	3.03804130
41	DNA double-strand break processing (GO:0000729)	3.03627989
42	protein complex biogenesis (GO:0070271)	3.03530599
43	tachykinin receptor signaling pathway (GO:0007217)	3.03250594
44	axoneme assembly (GO:0035082)	3.02239007
45	respiratory chain complex IV assembly (GO:0008535)	3.01275096
46	centriole replication (GO:0007099)	2.95933961
47	neuronal action potential (GO:0019228)	2.91219349
48	recombinational repair (GO:0000725)	2.90104714
49	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.89130606
50	signal peptide processing (GO:0006465)	2.88612171
51	protein localization to cilium (GO:0061512)	2.88418156
52	cilium morphogenesis (GO:0060271)	2.88401784
53	multicellular organism reproduction (GO:0032504)	2.88185822
54	double-strand break repair via homologous recombination (GO:0000724)	2.87851010
55	protein K11-linked deubiquitination (GO:0035871)	2.87271874
56	negative regulation of mast cell activation (GO:0033004)	2.85846180
57	mitochondrial respiratory chain complex assembly (GO:0033108)	2.85123814
58	inner ear receptor stereocilium organization (GO:0060122)	2.84613709
59	cilium organization (GO:0044782)	2.84304135
60	synapsis (GO:0007129)	2.83415156
61	DNA methylation involved in gamete generation (GO:0043046)	2.83012088
62	male meiosis I (GO:0007141)	2.82963168
63	regulation of cilium movement (GO:0003352)	2.81456911
64	amine catabolic process (GO:0009310)	2.77145519
65	cellular biogenic amine catabolic process (GO:0042402)	2.77145519
66	DNA deamination (GO:0045006)	2.76310738
67	cilium assembly (GO:0042384)	2.75307390
68	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.74321648
69	preassembly of GPI anchor in ER membrane (GO:0016254)	2.73760192
70	platelet dense granule organization (GO:0060155)	2.73400572
71	regulation of meiosis I (GO:0060631)	2.73316808
72	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72716485
73	protein-cofactor linkage (GO:0018065)	2.71954047
74	regulation of action potential (GO:0098900)	2.70458885
75	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.63557297
76	cytochrome complex assembly (GO:0017004)	2.62648945
77	L-methionine salvage (GO:0071267)	2.62546626
78	L-methionine biosynthetic process (GO:0071265)	2.62546626
79	amino acid salvage (GO:0043102)	2.62546626
80	sperm motility (GO:0030317)	2.61957028
81	transmission of nerve impulse (GO:0019226)	2.59460059
82	male meiosis (GO:0007140)	2.58994772
83	mannosylation (GO:0097502)	2.58570696
84	dopamine transport (GO:0015872)	2.56970208
85	photoreceptor cell development (GO:0042461)	2.56937422
86	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.56813195
87	regulation of mitotic spindle checkpoint (GO:1903504)	2.56813195
88	cornea development in camera-type eye (GO:0061303)	2.56219249
89	oxidative demethylation (GO:0070989)	2.54921276
90	spinal cord motor neuron differentiation (GO:0021522)	2.52216377
91	replication fork processing (GO:0031297)	2.51287997
92	intraciliary transport (GO:0042073)	2.49658348
93	rhodopsin mediated signaling pathway (GO:0016056)	2.49309001
94	cAMP catabolic process (GO:0006198)	2.48992633
95	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.48835047
96	synaptic transmission, cholinergic (GO:0007271)	2.47388803
97	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47303733
98	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.46451148
99	adaptation of signaling pathway (GO:0023058)	2.46157318
100	benzene-containing compound metabolic process (GO:0042537)	2.44463669

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.70938268
2	VDR_22108803_ChIP-Seq_LS180_Human	3.23958169
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.20859156
4	EZH2_22144423_ChIP-Seq_EOC_Human	2.96626080
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.80028031
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.73987953
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.72102669
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.65697029
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48910619
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.44603957
11	FUS_26573619_Chip-Seq_HEK293_Human	2.26794697
12	EWS_26573619_Chip-Seq_HEK293_Human	2.21562312
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.20576746
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.17744774
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15824793
16	P300_19829295_ChIP-Seq_ESCs_Human	2.13639123
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.97889879
18	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.97185631
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93970817
20	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84477334
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.78893237
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.76888368
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.75413551
24	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74825566
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.69320470
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68732111
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.67626041
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66955652
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65750772
30	STAT3_23295773_ChIP-Seq_U87_Human	1.65420690
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.63240217
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.63036722
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.63036722
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.58301492
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.56276673
36	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55508329
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55508329
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.54969473
39	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.54553245
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.53895464
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52557726
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.52136711
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.51714522
44	TCF4_23295773_ChIP-Seq_U87_Human	1.50686618
45	AR_25329375_ChIP-Seq_VCAP_Human	1.50180420
46	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48315612
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46408228
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.46197337
49	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.42578209
50	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.42509480
51	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.40169400
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37511402
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37511402
54	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.36643559
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.36228658
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.34395254
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.33770031
58	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.31574906
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.31483348
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31143335
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31143335
62	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29644556
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27905634
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27338552
65	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.26969223
66	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.26820665
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25998884
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.25391076
69	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24617850
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24583573
71	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23159981
72	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.22404547
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.22308008
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21026135
75	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20423979
76	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20168772
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.19046027
78	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18713840
79	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16551726
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15557647
81	NCOR_22424771_ChIP-Seq_293T_Human	1.12891628
82	AR_20517297_ChIP-Seq_VCAP_Human	1.09277420
83	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.07768989
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06490158
85	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04661141
86	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04545565
87	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04457146
88	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.04119723
89	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.03438637
90	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.03078533
91	CDX2_22108803_ChIP-Seq_LS180_Human	1.02699027
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01948625
93	* VDR_23849224_ChIP-Seq_CD4+_Human	1.01919188
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01440162
95	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.00077149
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.95021655
97	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94342542
98	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.93866620
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.93864664
100	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93810642

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.02241730
2	MP0000569_abnormal_digit_pigmentation	2.97778446
3	MP0003195_calcinosis	2.74588514
4	MP0005551_abnormal_eye_electrophysiolog	2.54701687
5	MP0002102_abnormal_ear_morphology	2.45882923
6	MP0001968_abnormal_touch/_nociception	2.30977641
7	MP0003136_yellow_coat_color	2.27910863
8	MP0006292_abnormal_olfactory_placode	2.23853742
9	MP0002736_abnormal_nociception_after	2.14578641
10	MP0006072_abnormal_retinal_apoptosis	2.10288501
11	MP0000372_irregular_coat_pigmentation	2.05796258
12	MP0009046_muscle_twitch	2.04645858
13	MP0003880_abnormal_central_pattern	1.92336626
14	MP0009745_abnormal_behavioral_response	1.89684001
15	MP0005253_abnormal_eye_physiology	1.85920548
16	MP0005646_abnormal_pituitary_gland	1.85259795
17	MP0001529_abnormal_vocalization	1.83653206
18	MP0003646_muscle_fatigue	1.82825762
19	MP0001986_abnormal_taste_sensitivity	1.82093480
20	MP0006276_abnormal_autonomic_nervous	1.81985151
21	MP0001501_abnormal_sleep_pattern	1.81435649
22	MP0008872_abnormal_physiological_respon	1.76617403
23	MP0001485_abnormal_pinna_reflex	1.70306325
24	MP0002272_abnormal_nervous_system	1.68238348
25	MP0001984_abnormal_olfaction	1.66052028
26	MP0003718_maternal_effect	1.65498318
27	MP0008875_abnormal_xenobiotic_pharmacok	1.63998562
28	MP0000427_abnormal_hair_cycle	1.62552965
29	MP0002138_abnormal_hepatobiliary_system	1.62129499
30	MP0004147_increased_porphyrin_level	1.61261470
31	MP0001486_abnormal_startle_reflex	1.57713367
32	MP0005645_abnormal_hypothalamus_physiol	1.57279877
33	MP0002837_dystrophic_cardiac_calcinosis	1.56968506
34	MP0000631_abnormal_neuroendocrine_gland	1.56621453
35	MP0004133_heterotaxia	1.56106249
36	MP0004142_abnormal_muscle_tone	1.55801076
37	MP0002638_abnormal_pupillary_reflex	1.53712069
38	MP0004742_abnormal_vestibular_system	1.49412723
39	MP0008058_abnormal_DNA_repair	1.47879750
40	MP0002938_white_spotting	1.47363348
41	MP0004885_abnormal_endolymph	1.46870567
42	MP0003787_abnormal_imprinting	1.45881233
43	MP0005410_abnormal_fertilization	1.42033597
44	MP0002160_abnormal_reproductive_system	1.42002264
45	MP0002735_abnormal_chemical_nociception	1.39959839
46	MP0004043_abnormal_pH_regulation	1.34601784
47	MP0002928_abnormal_bile_duct	1.33522233
48	MP0008057_abnormal_DNA_replication	1.32398267
49	MP0002572_abnormal_emotion/affect_behav	1.31364159
50	MP0005174_abnormal_tail_pigmentation	1.29728456
51	MP0005084_abnormal_gallbladder_morpholo	1.29351689
52	MP0003011_delayed_dark_adaptation	1.28828929
53	MP0005389_reproductive_system_phenotype	1.21585001
54	MP0002064_seizures	1.18417445
55	MP0002067_abnormal_sensory_capabilities	1.16511005
56	MP0003698_abnormal_male_reproductive	1.16487217
57	MP0010386_abnormal_urinary_bladder	1.15916613
58	MP0001929_abnormal_gametogenesis	1.15683385
59	MP0002557_abnormal_social/conspecific_i	1.14948857
60	MP0001970_abnormal_pain_threshold	1.13702788
61	MP0005377_hearing/vestibular/ear_phenot	1.10612947
62	MP0003878_abnormal_ear_physiology	1.10612947
63	MP0004924_abnormal_behavior	1.08438051
64	MP0005386_behavior/neurological_phenoty	1.08438051
65	MP0005085_abnormal_gallbladder_physiolo	1.07943625
66	MP0000383_abnormal_hair_follicle	1.07517893
67	MP0002234_abnormal_pharynx_morphology	1.07128401
68	MP0002653_abnormal_ependyma_morphology	1.05360054
69	MP0008995_early_reproductive_senescence	1.04137548
70	MP0002733_abnormal_thermal_nociception	1.04068646
71	MP0002210_abnormal_sex_determination	1.02984624
72	MP0003890_abnormal_embryonic-extraembry	1.02792046
73	MP0002876_abnormal_thyroid_physiology	1.01433484
74	MP0004215_abnormal_myocardial_fiber	0.99763744
75	MP0003635_abnormal_synaptic_transmissio	0.99653554
76	MP0002095_abnormal_skin_pigmentation	0.99188902
77	MP0005195_abnormal_posterior_eye	0.98273027
78	MP0004145_abnormal_muscle_electrophysio	0.97484898
79	MP0001764_abnormal_homeostasis	0.93314245
80	MP0000653_abnormal_sex_gland	0.91042091
81	MP0002734_abnormal_mechanical_nocicepti	0.90935639
82	MP0000026_abnormal_inner_ear	0.90743551
83	MP0002751_abnormal_autonomic_nervous	0.89874515
84	MP0005075_abnormal_melanosome_morpholog	0.89617880
85	MP0001905_abnormal_dopamine_level	0.89230280
86	MP0002063_abnormal_learning/memory/cond	0.88013409
87	MP0001963_abnormal_hearing_physiology	0.87106560
88	MP0002229_neurodegeneration	0.86996339
89	MP0002752_abnormal_somatic_nervous	0.86481259
90	MP0002822_catalepsy	0.86071069
91	MP0001145_abnormal_male_reproductive	0.85616419
92	MP0005171_absent_coat_pigmentation	0.84415715
93	MP0003252_abnormal_bile_duct	0.83194301
94	MP0003119_abnormal_digestive_system	0.82001046
95	MP0001324_abnormal_eye_pigmentation	0.81720411
96	MP0000647_abnormal_sebaceous_gland	0.79894279
97	MP0001919_abnormal_reproductive_system	0.79722745
98	MP0008789_abnormal_olfactory_epithelium	0.79293533
99	MP0010094_abnormal_chromosome_stability	0.78448303
100	MP0000230_abnormal_systemic_arterial	0.78197658

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.44929573
2	Pancreatic fibrosis (HP:0100732)	4.08926388
3	True hermaphroditism (HP:0010459)	3.99759016
4	Molar tooth sign on MRI (HP:0002419)	3.71484388
5	Abnormality of midbrain morphology (HP:0002418)	3.71484388
6	Nephronophthisis (HP:0000090)	3.50441046
7	Congenital stationary night blindness (HP:0007642)	3.47154241
8	Hyperventilation (HP:0002883)	3.33878376
9	Abnormality of the renal cortex (HP:0011035)	3.32159366
10	Attenuation of retinal blood vessels (HP:0007843)	3.28883809
11	Type II lissencephaly (HP:0007260)	3.22779864
12	Medial flaring of the eyebrow (HP:0010747)	3.20438567
13	Abnormality of the renal medulla (HP:0100957)	3.17821951
14	Chronic hepatic failure (HP:0100626)	3.00228233
15	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.97019345
16	Abnormality of alanine metabolism (HP:0010916)	2.97019345
17	Hyperalaninemia (HP:0003348)	2.97019345
18	Gaze-evoked nystagmus (HP:0000640)	2.91095967
19	Abolished electroretinogram (ERG) (HP:0000550)	2.78276271
20	Hypothermia (HP:0002045)	2.78018363
21	Cystic liver disease (HP:0006706)	2.77366859
22	Bony spicule pigmentary retinopathy (HP:0007737)	2.64511054
23	Tubular atrophy (HP:0000092)	2.61209632
24	Congenital, generalized hypertrichosis (HP:0004540)	2.61134241
25	Absent/shortened dynein arms (HP:0200106)	2.60064346
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.60064346
27	Inability to walk (HP:0002540)	2.58542333
28	Gait imbalance (HP:0002141)	2.55400873
29	Progressive inability to walk (HP:0002505)	2.51955813
30	Congenital primary aphakia (HP:0007707)	2.50969981
31	Genetic anticipation (HP:0003743)	2.50281448
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.49768274
33	Sclerocornea (HP:0000647)	2.47780996
34	Progressive cerebellar ataxia (HP:0002073)	2.46929307
35	Abnormal drinking behavior (HP:0030082)	2.46503053
36	Polydipsia (HP:0001959)	2.46503053
37	Abnormal biliary tract physiology (HP:0012439)	2.44212340
38	Bile duct proliferation (HP:0001408)	2.44212340
39	Nephrogenic diabetes insipidus (HP:0009806)	2.38438669
40	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.37980301
41	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.37374309
42	Cerebellar dysplasia (HP:0007033)	2.36535188
43	Renal cortical cysts (HP:0000803)	2.30850269
44	Congenital hepatic fibrosis (HP:0002612)	2.26597846
45	Pendular nystagmus (HP:0012043)	2.26291445
46	Anencephaly (HP:0002323)	2.19892110
47	Abnormal ciliary motility (HP:0012262)	2.19051888
48	Febrile seizures (HP:0002373)	2.18714677
49	Increased CSF lactate (HP:0002490)	2.18246107
50	Fair hair (HP:0002286)	2.17842387
51	Genital tract atresia (HP:0001827)	2.17381579
52	Congenital sensorineural hearing impairment (HP:0008527)	2.17222484
53	Furrowed tongue (HP:0000221)	2.15591463
54	Male pseudohermaphroditism (HP:0000037)	2.13496387
55	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.11393285
56	Decreased central vision (HP:0007663)	2.11079072
57	Broad-based gait (HP:0002136)	2.10826552
58	Large for gestational age (HP:0001520)	2.10773427
59	Acute necrotizing encephalopathy (HP:0006965)	2.10493574
60	Optic nerve hypoplasia (HP:0000609)	2.06819780
61	Lissencephaly (HP:0001339)	2.06471938
62	Polyuria (HP:0000103)	2.06212569
63	Abnormal respiratory epithelium morphology (HP:0012253)	2.05918530
64	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05918530
65	Vaginal atresia (HP:0000148)	2.04600642
66	Clumsiness (HP:0002312)	2.02281720
67	Postaxial foot polydactyly (HP:0001830)	2.02025697
68	Retinal dysplasia (HP:0007973)	2.01198242
69	Mitochondrial inheritance (HP:0001427)	1.99672298
70	Occipital encephalocele (HP:0002085)	1.98574654
71	Birth length less than 3rd percentile (HP:0003561)	1.97407955
72	Methylmalonic aciduria (HP:0012120)	1.97304092
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97138887
74	Methylmalonic acidemia (HP:0002912)	1.94990888
75	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93900861
76	Intestinal atresia (HP:0011100)	1.93255113
77	Acute encephalopathy (HP:0006846)	1.92193376
78	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.90715448
79	Keratoconus (HP:0000563)	1.90052710
80	Increased corneal curvature (HP:0100692)	1.90052710
81	Oligodactyly (hands) (HP:0001180)	1.90009395
82	Progressive macrocephaly (HP:0004481)	1.88133474
83	Absent speech (HP:0001344)	1.86942944
84	Focal motor seizures (HP:0011153)	1.85504506
85	Stomach cancer (HP:0012126)	1.84688565
86	Constricted visual fields (HP:0001133)	1.84199852
87	Abnormality of the labia minora (HP:0012880)	1.84031357
88	Decreased circulating renin level (HP:0003351)	1.83125823
89	Optic disc pallor (HP:0000543)	1.83099588
90	3-Methylglutaconic aciduria (HP:0003535)	1.82642073
91	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81979962
92	Retinitis pigmentosa (HP:0000510)	1.80884681
93	Poor coordination (HP:0002370)	1.79960307
94	Patellar aplasia (HP:0006443)	1.77764031
95	Protruding tongue (HP:0010808)	1.76034919
96	Astigmatism (HP:0000483)	1.75335418
97	Abnormality of the pons (HP:0007361)	1.74803036
98	Small hand (HP:0200055)	1.74597027
99	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.73784053
100	Postaxial hand polydactyly (HP:0001162)	1.73496300

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.23759255
2	BMPR1B	3.42458620
3	ADRBK2	2.95144480
4	WNK3	2.65435089
5	INSRR	2.63385276
6	TAOK3	2.50908337
7	MAP4K2	2.41403073
8	ACVR1B	2.38246045
9	ZAK	2.35190731
10	NUAK1	2.26624356
11	PINK1	2.13483534
12	GRK1	1.98108935
13	CASK	1.95464020
14	WNK4	1.91776210
15	TLK1	1.90903178
16	MAPK13	1.82697269
17	MAP3K4	1.81315434
18	PNCK	1.49990062
19	MKNK2	1.37727335
20	MAPK15	1.33809624
21	VRK1	1.30349420
22	OXSR1	1.28567185
23	TXK	1.23007273
24	TNIK	1.19499833
25	STK39	1.17282868
26	PAK3	1.16415554
27	BRSK2	1.15307454
28	ADRBK1	1.11234708
29	WEE1	1.09272921
30	MARK1	1.08622963
31	TRIM28	1.08305707
32	DAPK2	1.08237667
33	TGFBR1	1.06770097
34	MAP2K7	1.05662670
35	STK38L	1.03502235
36	DYRK2	1.01734166
37	TIE1	1.01204751
38	CAMKK2	0.95171947
39	PRKCG	0.89291403
40	STK16	0.88031841
41	MUSK	0.86538138
42	PRKCE	0.85302347
43	CSNK1G2	0.85252990
44	PLK2	0.83466371
45	CSNK1G1	0.82219739
46	MKNK1	0.82156136
47	PLK4	0.82152738
48	PTK2B	0.79250367
49	PLK3	0.74548668
50	CSNK1G3	0.73625452
51	TSSK6	0.71782154
52	BCKDK	0.70983890
53	CSNK1A1L	0.70536539
54	BCR	0.69624305
55	MAPKAPK5	0.65530359
56	MST4	0.62056285
57	VRK2	0.60452212
58	EPHA4	0.59977512
59	NTRK3	0.58675913
60	MAP3K9	0.57746558
61	PKN1	0.57533324
62	TEC	0.56931119
63	ERBB3	0.56528620
64	TAF1	0.56006059
65	PIK3CG	0.55606857
66	CAMK2A	0.53711252
67	NEK2	0.53063252
68	IKBKB	0.52534482
69	RPS6KA5	0.50731228
70	NME1	0.49735260
71	STK3	0.48854955
72	DYRK3	0.48584464
73	PLK1	0.47562762
74	CDK8	0.43973735
75	PHKG1	0.43970298
76	PHKG2	0.43970298
77	PRKACA	0.43095406
78	MAPKAPK3	0.42153744
79	CHUK	0.41130877
80	CHEK2	0.40449092
81	IRAK1	0.40342141
82	EIF2AK3	0.38515978
83	PRKCQ	0.38330926
84	MAP3K7	0.37507930
85	PIK3CA	0.37093666
86	CCNB1	0.36855195
87	CSNK1D	0.36635195
88	CAMK1	0.35967355
89	FER	0.35706390
90	FLT3	0.35396114
91	CDK3	0.35174989
92	OBSCN	0.35119645
93	PRKG1	0.34251887
94	NLK	0.33147866
95	ATR	0.32867999
96	MAP3K13	0.32497672
97	CSNK1A1	0.32390559
98	PRKAA2	0.32115375
99	GRK5	0.31750950
100	PRKACB	0.31361455

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.71782624
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.51625472
3	Homologous recombination_Homo sapiens_hsa03440	2.43531181
4	Butanoate metabolism_Homo sapiens_hsa00650	2.43177046
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40183613
6	Nicotine addiction_Homo sapiens_hsa05033	2.39863878
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.35304245
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.32533199
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.31549259
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.21183562
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.17607594
12	Basal transcription factors_Homo sapiens_hsa03022	2.09175049
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.05399352
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.02456054
15	Tryptophan metabolism_Homo sapiens_hsa00380	2.00842829
16	Selenocompound metabolism_Homo sapiens_hsa00450	2.00497199
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.89065051
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.87132511
19	RNA polymerase_Homo sapiens_hsa03020	1.85726466
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.81267264
21	Protein export_Homo sapiens_hsa03060	1.73091155
22	Parkinsons disease_Homo sapiens_hsa05012	1.67791564
23	Propanoate metabolism_Homo sapiens_hsa00640	1.67419147
24	Caffeine metabolism_Homo sapiens_hsa00232	1.64968014
25	Taste transduction_Homo sapiens_hsa04742	1.64627159
26	Olfactory transduction_Homo sapiens_hsa04740	1.58608507
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.58063242
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.50650349
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.46838924
30	Morphine addiction_Homo sapiens_hsa05032	1.38738053
31	One carbon pool by folate_Homo sapiens_hsa00670	1.38190398
32	Huntingtons disease_Homo sapiens_hsa05016	1.33737501
33	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.30199381
34	ABC transporters_Homo sapiens_hsa02010	1.28539628
35	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25421680
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24369665
37	RNA degradation_Homo sapiens_hsa03018	1.24369382
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20299219
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15906720
40	Retinol metabolism_Homo sapiens_hsa00830	1.09553075
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07964249
42	GABAergic synapse_Homo sapiens_hsa04727	1.05394061
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.03279667
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.03176733
45	Regulation of autophagy_Homo sapiens_hsa04140	1.01826456
46	Alzheimers disease_Homo sapiens_hsa05010	0.97085385
47	Serotonergic synapse_Homo sapiens_hsa04726	0.95413605
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.95320557
49	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.95220446
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.94739325
51	Peroxisome_Homo sapiens_hsa04146	0.94155467
52	beta-Alanine metabolism_Homo sapiens_hsa00410	0.91904555
53	Circadian entrainment_Homo sapiens_hsa04713	0.90311822
54	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.90300835
55	Purine metabolism_Homo sapiens_hsa00230	0.88713586
56	Cardiac muscle contraction_Homo sapiens_hsa04260	0.88591002
57	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.86333673
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.86186450
59	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.85767736
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.84699506
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.83897240
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72232493
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.71416733
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.70538099
65	Calcium signaling pathway_Homo sapiens_hsa04020	0.69682712
66	Proteasome_Homo sapiens_hsa03050	0.69423220
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66752025
68	Metabolic pathways_Homo sapiens_hsa01100	0.66508192
69	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64673680
70	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63207614
71	Salivary secretion_Homo sapiens_hsa04970	0.63072601
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.62939289
73	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61827789
74	Insulin secretion_Homo sapiens_hsa04911	0.60801906
75	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.57306599
76	Mismatch repair_Homo sapiens_hsa03430	0.56729191
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.56262699
78	Fat digestion and absorption_Homo sapiens_hsa04975	0.54606854
79	Circadian rhythm_Homo sapiens_hsa04710	0.54313141
80	Histidine metabolism_Homo sapiens_hsa00340	0.53775973
81	Fatty acid degradation_Homo sapiens_hsa00071	0.47866671
82	Sulfur relay system_Homo sapiens_hsa04122	0.45620628
83	Base excision repair_Homo sapiens_hsa03410	0.45504533
84	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.42957526
85	Sulfur metabolism_Homo sapiens_hsa00920	0.42667419
86	Steroid biosynthesis_Homo sapiens_hsa00100	0.42600107
87	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38417355
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.36539493
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.35432061
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.35399520
91	RNA transport_Homo sapiens_hsa03013	0.35211882
92	Mineral absorption_Homo sapiens_hsa04978	0.34596492
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33526075
94	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.31981652
95	Long-term depression_Homo sapiens_hsa04730	0.31967448
96	Asthma_Homo sapiens_hsa05310	0.31872417
97	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.31565940
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.31342095
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30697107
100	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.29874270

C12ORF60

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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