C12orf66

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)5.54471792
2prenylation (GO:0097354)5.54471792
3L-fucose catabolic process (GO:0042355)5.17895636
4fucose catabolic process (GO:0019317)5.17895636
5L-fucose metabolic process (GO:0042354)5.17895636
6positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.01548037
7positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.01548037
8positive regulation of mitotic sister chromatid separation (GO:1901970)5.01548037
9preassembly of GPI anchor in ER membrane (GO:0016254)4.39707642
10DNA deamination (GO:0045006)4.26196862
11proteasome assembly (GO:0043248)3.75961593
12water-soluble vitamin biosynthetic process (GO:0042364)3.67178271
13tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.62150537
14RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.62150537
15mannosylation (GO:0097502)3.53960332
16mitochondrial RNA metabolic process (GO:0000959)3.43701841
17DNA double-strand break processing (GO:0000729)3.42683630
18cellular ketone body metabolic process (GO:0046950)3.30150979
19GPI anchor metabolic process (GO:0006505)3.25523873
20rRNA modification (GO:0000154)3.22201597
21piRNA metabolic process (GO:0034587)3.17584059
22synapsis (GO:0007129)3.16844979
23protein import into peroxisome matrix (GO:0016558)3.15484454
24response to pheromone (GO:0019236)3.12268349
25S-adenosylmethionine metabolic process (GO:0046500)3.09782092
26positive regulation of chromosome segregation (GO:0051984)3.09446902
27double-strand break repair via homologous recombination (GO:0000724)3.08026594
28replication fork processing (GO:0031297)3.07910420
29coenzyme catabolic process (GO:0009109)3.06517397
30GPI anchor biosynthetic process (GO:0006506)3.05831154
31recombinational repair (GO:0000725)3.05827089
32ketone body metabolic process (GO:1902224)3.05003578
33peptidyl-histidine modification (GO:0018202)3.04940650
34maturation of 5.8S rRNA (GO:0000460)3.04801861
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.04499843
36organelle membrane fusion (GO:0090174)3.01901399
37rRNA methylation (GO:0031167)2.99973917
38keratinocyte development (GO:0003334)2.98076025
39negative regulation of T cell receptor signaling pathway (GO:0050860)2.96359286
40autophagic vacuole fusion (GO:0000046)2.93882774
41C-terminal protein lipidation (GO:0006501)2.91535303
42histone H3-K9 methylation (GO:0051567)2.88404601
43somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86184680
44somatic hypermutation of immunoglobulin genes (GO:0016446)2.86184680
45regulation of T cell receptor signaling pathway (GO:0050856)2.81542372
46tRNA processing (GO:0008033)2.81404055
47negative regulation of DNA-dependent DNA replication (GO:2000104)2.79603506
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77809552
49regulation of nuclear cell cycle DNA replication (GO:0033262)2.74931341
50tRNA modification (GO:0006400)2.74775891
51negative regulation of Ras GTPase activity (GO:0034261)2.73995370
52tryptophan catabolic process (GO:0006569)2.73825488
53indole-containing compound catabolic process (GO:0042436)2.73825488
54indolalkylamine catabolic process (GO:0046218)2.73825488
55pseudouridine synthesis (GO:0001522)2.70811990
56DNA replication checkpoint (GO:0000076)2.68968866
57tryptophan metabolic process (GO:0006568)2.67677935
58somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67131311
59somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67131311
60isotype switching (GO:0045190)2.67131311
61phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63949667
62oxidative demethylation (GO:0070989)2.63138135
63respiratory chain complex IV assembly (GO:0008535)2.61156036
64non-recombinational repair (GO:0000726)2.60828411
65double-strand break repair via nonhomologous end joining (GO:0006303)2.60828411
66C-terminal protein amino acid modification (GO:0018410)2.60243109
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.59968122
68RNA methylation (GO:0001510)2.59411966
69DNA methylation involved in gamete generation (GO:0043046)2.58738743
70behavioral response to nicotine (GO:0035095)2.57423374
71rRNA catabolic process (GO:0016075)2.55190437
72transcription elongation from RNA polymerase III promoter (GO:0006385)2.54865833
73termination of RNA polymerase III transcription (GO:0006386)2.54865833
74organ growth (GO:0035265)2.52361617
75amino acid salvage (GO:0043102)2.52332711
76L-methionine salvage (GO:0071267)2.52332711
77L-methionine biosynthetic process (GO:0071265)2.52332711
78platelet dense granule organization (GO:0060155)2.51483234
79protein K6-linked ubiquitination (GO:0085020)2.51148132
80inositol phosphate catabolic process (GO:0071545)2.50936158
81protein targeting to peroxisome (GO:0006625)2.47543139
82establishment of protein localization to peroxisome (GO:0072663)2.47543139
83protein localization to peroxisome (GO:0072662)2.47543139
84methionine biosynthetic process (GO:0009086)2.47389198
85seminiferous tubule development (GO:0072520)2.47080600
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46940695
87indolalkylamine metabolic process (GO:0006586)2.46916905
88protein sumoylation (GO:0016925)2.46843121
89RNA modification (GO:0009451)2.46185391
90DNA demethylation (GO:0080111)2.45661473
91branched-chain amino acid catabolic process (GO:0009083)2.44056707
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.43569685
93adenosine metabolic process (GO:0046085)2.42402007
94positive regulation of prostaglandin secretion (GO:0032308)2.41046006
95tRNA metabolic process (GO:0006399)2.40951253
96regulation of hexokinase activity (GO:1903299)2.39938601
97regulation of glucokinase activity (GO:0033131)2.39938601
98regulation of sister chromatid cohesion (GO:0007063)2.39542910
99intracellular pH reduction (GO:0051452)2.39435798
100phosphorylated carbohydrate dephosphorylation (GO:0046838)2.39258254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42947208
2VDR_22108803_ChIP-Seq_LS180_Human3.42403181
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.34937444
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.28356082
5ZNF274_21170338_ChIP-Seq_K562_Hela3.19350867
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.87245524
7* NOTCH1_21737748_ChIP-Seq_TLL_Human2.81062827
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73419258
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.60616096
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53623699
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.43588451
12GATA1_22025678_ChIP-Seq_K562_Human2.38718049
13VDR_23849224_ChIP-Seq_CD4+_Human2.32959823
14FUS_26573619_Chip-Seq_HEK293_Human2.17519660
15ELK1_19687146_ChIP-ChIP_HELA_Human2.15894050
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12321585
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10400006
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.07641089
19IGF1R_20145208_ChIP-Seq_DFB_Human2.07117474
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95301374
21EWS_26573619_Chip-Seq_HEK293_Human1.91910303
22ETS1_20019798_ChIP-Seq_JURKAT_Human1.89927790
23IRF1_19129219_ChIP-ChIP_H3396_Human1.89187356
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86925739
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85656713
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.84641404
27ER_23166858_ChIP-Seq_MCF-7_Human1.84497490
28MYC_18940864_ChIP-ChIP_HL60_Human1.83259020
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.78853238
30FOXP3_21729870_ChIP-Seq_TREG_Human1.78416525
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76909297
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.73844088
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.73092271
34GBX2_23144817_ChIP-Seq_PC3_Human1.67022819
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.65664789
36BCAT_22108803_ChIP-Seq_LS180_Human1.60617516
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58447394
38TAF15_26573619_Chip-Seq_HEK293_Human1.57096144
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.56543679
40* P300_19829295_ChIP-Seq_ESCs_Human1.54821368
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.50359509
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.50059718
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48647618
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47484375
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.45524573
46* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43254260
47* FOXA1_25329375_ChIP-Seq_VCAP_Human1.43254260
48TP53_22573176_ChIP-Seq_HFKS_Human1.42533052
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41294412
50CBP_20019798_ChIP-Seq_JUKART_Human1.41251700
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41251700
52* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33347323
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32754269
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.30338557
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27952401
56NANOG_19829295_ChIP-Seq_ESCs_Human1.25321379
57SOX2_19829295_ChIP-Seq_ESCs_Human1.25321379
58HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23799902
59AR_20517297_ChIP-Seq_VCAP_Human1.23342715
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22915625
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21388554
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20213997
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.18807641
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18712076
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17476942
66TCF4_22108803_ChIP-Seq_LS180_Human1.14085542
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.13024307
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12288715
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11957517
70GATA3_26560356_Chip-Seq_TH1_Human1.10899947
71CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08060067
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06616979
73STAT3_23295773_ChIP-Seq_U87_Human1.05869027
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04198711
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03143903
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02700744
77CDX2_22108803_ChIP-Seq_LS180_Human1.01745724
78NCOR_22424771_ChIP-Seq_293T_Human0.99198505
79GATA3_26560356_Chip-Seq_TH2_Human0.99188109
80TCF4_23295773_ChIP-Seq_U87_Human0.97780414
81TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97136858
82* GATA3_21878914_ChIP-Seq_MCF-7_Human0.96757292
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96464913
84CRX_20693478_ChIP-Seq_RETINA_Mouse0.96340397
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96298838
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95150226
87STAT3_18555785_Chip-Seq_ESCs_Mouse0.93357961
88CREB1_15753290_ChIP-ChIP_HEK293T_Human0.93125302
89GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92281895
90PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91335138
91FOXH1_21741376_ChIP-Seq_EPCs_Human0.90517078
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90461415
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89979232
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87951658
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.87036788
96GABP_19822575_ChIP-Seq_HepG2_Human0.86364898
97SMAD4_21799915_ChIP-Seq_A2780_Human0.86185569
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86081570
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85404023
100P300_18555785_Chip-Seq_ESCs_Mouse0.85235717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.92283029
2MP0008877_abnormal_DNA_methylation3.66693647
3MP0008057_abnormal_DNA_replication2.66995055
4MP0000566_synostosis2.65383430
5MP0002138_abnormal_hepatobiliary_system2.46500965
6MP0008058_abnormal_DNA_repair2.45496237
7MP0001919_abnormal_reproductive_system2.40074064
8MP0002163_abnormal_gland_morphology2.30163262
9MP0004147_increased_porphyrin_level2.27383547
10MP0005646_abnormal_pituitary_gland2.25092035
11MP0002876_abnormal_thyroid_physiology2.23857237
12MP0003787_abnormal_imprinting2.20413906
13MP0005389_reproductive_system_phenotype2.19479749
14MP0002837_dystrophic_cardiac_calcinosis2.16573755
15MP0006292_abnormal_olfactory_placode2.16097582
16MP0002160_abnormal_reproductive_system2.11089730
17MP0000383_abnormal_hair_follicle2.00238557
18MP0005645_abnormal_hypothalamus_physiol1.83121795
19MP0003718_maternal_effect1.81845712
20MP0005379_endocrine/exocrine_gland_phen1.78275031
21MP0010678_abnormal_skin_adnexa1.77461187
22MP0005551_abnormal_eye_electrophysiolog1.76027841
23MP0010094_abnormal_chromosome_stability1.72262913
24MP0002638_abnormal_pupillary_reflex1.64665947
25MP0006072_abnormal_retinal_apoptosis1.63955420
26MP0000427_abnormal_hair_cycle1.58866144
27MP0008872_abnormal_physiological_respon1.58504979
28MP0005253_abnormal_eye_physiology1.55778560
29MP0005075_abnormal_melanosome_morpholog1.54538336
30MP0000372_irregular_coat_pigmentation1.54325926
31MP0002009_preneoplasia1.54324710
32MP0003693_abnormal_embryo_hatching1.52773635
33MP0005084_abnormal_gallbladder_morpholo1.49192634
34MP0002254_reproductive_system_inflammat1.47871366
35MP0005410_abnormal_fertilization1.47519600
36MP0005220_abnormal_exocrine_pancreas1.44870086
37MP0003786_premature_aging1.37195277
38MP0002938_white_spotting1.32549447
39MP0001661_extended_life_span1.32443326
40MP0002166_altered_tumor_susceptibility1.30780484
41MP0001485_abnormal_pinna_reflex1.29466401
42MP0001764_abnormal_homeostasis1.27618408
43MP0001929_abnormal_gametogenesis1.20903892
44MP0003646_muscle_fatigue1.19869812
45MP0008995_early_reproductive_senescence1.19802295
46MP0004885_abnormal_endolymph1.18687506
47MP0001664_abnormal_digestion1.17766933
48MP0003011_delayed_dark_adaptation1.17317894
49MP0002102_abnormal_ear_morphology1.16402856
50MP0008875_abnormal_xenobiotic_pharmacok1.14526333
51MP0008007_abnormal_cellular_replicative1.09894723
52MP0003252_abnormal_bile_duct1.08829765
53MP0002751_abnormal_autonomic_nervous1.08338274
54MP0005332_abnormal_amino_acid1.07771672
55MP0005174_abnormal_tail_pigmentation1.04938513
56MP0002693_abnormal_pancreas_physiology1.03771487
57MP0001986_abnormal_taste_sensitivity1.01784749
58MP0002210_abnormal_sex_determination1.01536927
59MP0000516_abnormal_urinary_system1.00919548
60MP0005367_renal/urinary_system_phenotyp1.00919548
61MP0001968_abnormal_touch/_nociception1.00528835
62MP0004142_abnormal_muscle_tone0.98911472
63MP0000653_abnormal_sex_gland0.98360189
64MP0001145_abnormal_male_reproductive0.97799905
65MP0001873_stomach_inflammation0.97058452
66MP0002006_tumorigenesis0.97056608
67MP0004043_abnormal_pH_regulation0.96130781
68MP0003303_peritoneal_inflammation0.94675343
69MP0000613_abnormal_salivary_gland0.92924502
70MP0002736_abnormal_nociception_after0.91056870
71MP0000013_abnormal_adipose_tissue0.90896104
72MP0001119_abnormal_female_reproductive0.90339953
73MP0003763_abnormal_thymus_physiology0.90042343
74MP0001944_abnormal_pancreas_morphology0.90005769
75MP0000470_abnormal_stomach_morphology0.88121231
76MP0005397_hematopoietic_system_phenotyp0.87129860
77MP0001545_abnormal_hematopoietic_system0.87129860
78MP0003698_abnormal_male_reproductive0.86369975
79MP0006082_CNS_inflammation0.86157104
80MP0006036_abnormal_mitochondrial_physio0.83630711
81MP0000631_abnormal_neuroendocrine_gland0.82904966
82MP0000467_abnormal_esophagus_morphology0.82774537
83MP0003283_abnormal_digestive_organ0.81968560
84MP0001663_abnormal_digestive_system0.80182998
85MP0001529_abnormal_vocalization0.79787061
86MP0002928_abnormal_bile_duct0.78538378
87MP0009697_abnormal_copulation0.75146636
88MP0002139_abnormal_hepatobiliary_system0.73187244
89MP0010329_abnormal_lipoprotein_level0.72728920
90MP0001984_abnormal_olfaction0.71968527
91MP0000569_abnormal_digit_pigmentation0.70580292
92MP0002909_abnormal_adrenal_gland0.70027246
93MP0002019_abnormal_tumor_incidence0.69069078
94MP0005085_abnormal_gallbladder_physiolo0.68909491
95MP0005671_abnormal_response_to0.67026109
96MP0002277_abnormal_respiratory_mucosa0.66006657
97MP0010234_abnormal_vibrissa_follicle0.65963853
98MP0003937_abnormal_limbs/digits/tail_de0.65470452
99MP0001727_abnormal_embryo_implantation0.65370353
100MP0006035_abnormal_mitochondrial_morpho0.64049714

Predicted human phenotypes

RankGene SetZ-score
1Large for gestational age (HP:0001520)3.36296903
2Duplicated collecting system (HP:0000081)3.30361290
3Abnormality of the renal collecting system (HP:0004742)3.29460166
4Attenuation of retinal blood vessels (HP:0007843)3.09237426
5Pancreatic cysts (HP:0001737)3.03900464
6Congenital stationary night blindness (HP:0007642)3.01465569
7Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.94863510
8Abnormal rod and cone electroretinograms (HP:0008323)2.94682400
9Absent rod-and cone-mediated responses on ERG (HP:0007688)2.80470907
10Methylmalonic acidemia (HP:0002912)2.78570952
11Renal cortical cysts (HP:0000803)2.68421183
12Acute lymphatic leukemia (HP:0006721)2.67816777
13Abnormality of the renal cortex (HP:0011035)2.67229975
14Molar tooth sign on MRI (HP:0002419)2.66610971
15Abnormality of midbrain morphology (HP:0002418)2.66610971
16Pancreatic fibrosis (HP:0100732)2.64404257
17Chromsome breakage (HP:0040012)2.56343787
18Nephronophthisis (HP:0000090)2.56083846
19Hyperglycinuria (HP:0003108)2.55281750
20Abnormality of chromosome stability (HP:0003220)2.50876132
21Pendular nystagmus (HP:0012043)2.50282957
22True hermaphroditism (HP:0010459)2.44947443
23Neoplasm of the adrenal cortex (HP:0100641)2.42543598
24Abolished electroretinogram (ERG) (HP:0000550)2.39116498
25Clubbing of toes (HP:0100760)2.37746881
26Abnormal protein N-linked glycosylation (HP:0012347)2.37358374
27Abnormal protein glycosylation (HP:0012346)2.37358374
28Abnormal glycosylation (HP:0012345)2.37358374
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.37358374
30Abnormality of the pons (HP:0007361)2.36751533
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.36330702
32Type II lissencephaly (HP:0007260)2.31945928
33Brushfield spots (HP:0001088)2.31463552
34Severe muscular hypotonia (HP:0006829)2.30969616
35Thyroiditis (HP:0100646)2.29856363
36Hypoplasia of the pons (HP:0012110)2.29597767
37Abnormality of fatty-acid metabolism (HP:0004359)2.28689400
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28330197
39Hypomagnesemia (HP:0002917)2.23420208
40Methylmalonic aciduria (HP:0012120)2.23209709
41Ketoacidosis (HP:0001993)2.21472385
42Type I transferrin isoform profile (HP:0003642)2.21451072
43Absent/shortened dynein arms (HP:0200106)2.21404604
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.21404604
45Abnormality of the renal medulla (HP:0100957)2.15926507
46Decreased central vision (HP:0007663)2.15347380
47Absent thumb (HP:0009777)2.15193399
48Hypothermia (HP:0002045)2.13225703
49Gaze-evoked nystagmus (HP:0000640)2.13039435
50Polydipsia (HP:0001959)2.10883378
51Abnormal drinking behavior (HP:0030082)2.10883378
52Ketosis (HP:0001946)2.10702640
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.10499317
54Hypoplasia of the fovea (HP:0007750)2.10499317
55Abnormality of alanine metabolism (HP:0010916)2.10495913
56Hyperalaninemia (HP:0003348)2.10495913
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10495913
58Meckel diverticulum (HP:0002245)2.08218239
59Abnormality of the ileum (HP:0001549)2.07478840
60Abnormality of glycine metabolism (HP:0010895)2.01615829
61Abnormality of serine family amino acid metabolism (HP:0010894)2.01615829
62Acute encephalopathy (HP:0006846)2.01612729
63Abnormality of B cell number (HP:0010975)2.01449825
64IgG deficiency (HP:0004315)1.99957667
65Concave nail (HP:0001598)1.99919659
66Tachypnea (HP:0002789)1.98475316
67Abnormality of the preputium (HP:0100587)1.97484879
68B lymphocytopenia (HP:0010976)1.95300522
69Progressive macrocephaly (HP:0004481)1.94637129
70Dry hair (HP:0011359)1.94524050
71Hyperglycinemia (HP:0002154)1.94508473
72Abnormal biliary tract physiology (HP:0012439)1.92941483
73Bile duct proliferation (HP:0001408)1.92941483
74Lactic acidosis (HP:0003128)1.90590415
75Abnormality of macular pigmentation (HP:0008002)1.90129888
76Metabolic acidosis (HP:0001942)1.89754648
77Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87357213
78Medial flaring of the eyebrow (HP:0010747)1.84358555
79Increased CSF lactate (HP:0002490)1.84086594
80Hyperinsulinemic hypoglycemia (HP:0000825)1.83351076
81Lipid accumulation in hepatocytes (HP:0006561)1.83106746
82Prostate neoplasm (HP:0100787)1.82395815
83Mitochondrial inheritance (HP:0001427)1.81798251
84Cerebellar dysplasia (HP:0007033)1.79885118
85Hypoproteinemia (HP:0003075)1.79663994
86Polyuria (HP:0000103)1.79561909
87Acute necrotizing encephalopathy (HP:0006965)1.77816617
88Aplasia/hypoplasia of the uterus (HP:0008684)1.77814431
89Chorioretinal atrophy (HP:0000533)1.76897345
90Hepatic necrosis (HP:0002605)1.76264301
91Increased serum lactate (HP:0002151)1.75210927
92Disproportionate short-trunk short stature (HP:0003521)1.74366705
93Bony spicule pigmentary retinopathy (HP:0007737)1.73501679
94Carpal bone hypoplasia (HP:0001498)1.72807504
95Short 1st metacarpal (HP:0010034)1.70950255
96Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70950255
97Chronic hepatic failure (HP:0100626)1.70766683
98Abnormality of the fovea (HP:0000493)1.70707176
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69654956
100Dicarboxylic aciduria (HP:0003215)1.69654956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK26.14758768
2FRK5.77220066
3MKNK13.99689204
4GRK13.08184670
5ADRBK22.53246752
6ZAK2.43544404
7TAF12.38022758
8NUAK12.12148256
9EIF2AK32.11168436
10MAP4K21.83974817
11BMPR1B1.75366316
12TLK11.71689380
13ACVR1B1.70070069
14TRIM281.63598202
15VRK21.60064889
16TAOK11.53724316
17JAK31.52555837
18MAP2K31.45103976
19TAOK31.41867943
20FLT31.41263088
21VRK11.34563722
22PINK11.29914599
23OXSR11.25812718
24MAP3K31.24550621
25INSRR1.24146471
26TAOK21.19915780
27PLK31.18987343
28CDC71.14234641
29KIT1.12306241
30PLK21.10395844
31FGFR21.07130736
32PBK1.05829641
33SRPK11.05292911
34WNK31.05212921
35MST41.01816870
36STK390.95722352
37BRSK20.93785943
38BCKDK0.91829562
39WNK40.85878661
40BUB10.85517010
41CAMKK20.85496627
42MAP3K110.83904763
43TNK20.83153494
44TEC0.82749549
45EIF2AK10.76739335
46MAPKAPK50.75353910
47CHEK20.75005322
48PRKCQ0.74008799
49AKT30.70294796
50MAP3K40.68421060
51DAPK20.66752879
52TNIK0.63556763
53PASK0.63124500
54NLK0.62969622
55NEK20.62946817
56ERBB30.61623941
57RPS6KB20.59966816
58ATR0.59911879
59CSNK1G10.59593159
60DYRK1A0.59487560
61BMPR20.58426907
62IKBKB0.58382906
63PLK40.57382568
64MAP2K60.55280901
65MAPKAPK30.55066973
66PRKCE0.54998137
67ABL20.54937648
68IRAK10.53641367
69TTK0.53546948
70MAPK130.53366104
71CSNK1G30.52775763
72MAP3K50.51487312
73CDK90.51003442
74PLK10.50548486
75EIF2AK20.49801524
76TSSK60.48955287
77RPS6KA50.47548704
78RPS6KB10.46949578
79ITK0.45577685
80TRPM70.44480741
81TXK0.44140460
82PRKCI0.42595948
83PHKG20.42392274
84PHKG10.42392274
85PIK3CA0.40398581
86MAP2K20.40206725
87PDK20.38708821
88GRK60.37621342
89ATM0.37527979
90CSNK1G20.36609053
91PTK2B0.36256188
92NME10.35391306
93CSNK1A1L0.35269110
94WEE10.35166488
95CDK190.34035370
96PRKCG0.32962141
97MAP3K10.32418025
98TGFBR10.31907443
99CHUK0.31668777
100DAPK10.31494302

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.17799158
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.00755600
3RNA polymerase_Homo sapiens_hsa030202.53374414
4Butanoate metabolism_Homo sapiens_hsa006502.32182473
5Basal transcription factors_Homo sapiens_hsa030222.30316993
6Propanoate metabolism_Homo sapiens_hsa006402.29797413
7Homologous recombination_Homo sapiens_hsa034402.26858453
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23284819
9Protein export_Homo sapiens_hsa030602.19671373
10Linoleic acid metabolism_Homo sapiens_hsa005912.12744345
11Proteasome_Homo sapiens_hsa030502.11986329
12Fanconi anemia pathway_Homo sapiens_hsa034602.08351510
13Non-homologous end-joining_Homo sapiens_hsa034502.06209169
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.98831854
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98382168
16One carbon pool by folate_Homo sapiens_hsa006701.82496017
17Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.77693488
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76318758
19Peroxisome_Homo sapiens_hsa041461.75167217
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73647804
21Selenocompound metabolism_Homo sapiens_hsa004501.72261600
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68306017
23Phototransduction_Homo sapiens_hsa047441.60439573
24RNA degradation_Homo sapiens_hsa030181.58084102
25Tryptophan metabolism_Homo sapiens_hsa003801.57792235
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.49637533
27Ether lipid metabolism_Homo sapiens_hsa005651.48967892
28Nucleotide excision repair_Homo sapiens_hsa034201.48716794
29Caffeine metabolism_Homo sapiens_hsa002321.45683555
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44856910
31Arachidonic acid metabolism_Homo sapiens_hsa005901.36948146
32Nitrogen metabolism_Homo sapiens_hsa009101.34726232
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.27856864
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24524495
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20863865
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16878831
37Primary immunodeficiency_Homo sapiens_hsa053401.14436706
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13484284
39Sulfur metabolism_Homo sapiens_hsa009201.13107616
40Chemical carcinogenesis_Homo sapiens_hsa052041.12185732
41RNA transport_Homo sapiens_hsa030131.12012324
42DNA replication_Homo sapiens_hsa030301.11596371
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11049459
44Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10337102
45Fatty acid elongation_Homo sapiens_hsa000621.09524727
46Mismatch repair_Homo sapiens_hsa034301.08155235
47Purine metabolism_Homo sapiens_hsa002301.07483695
48Oxidative phosphorylation_Homo sapiens_hsa001901.03474034
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02619186
50Intestinal immune network for IgA production_Homo sapiens_hsa046721.01557933
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.01052643
52Fatty acid degradation_Homo sapiens_hsa000711.00519344
53beta-Alanine metabolism_Homo sapiens_hsa004101.00161075
54Taste transduction_Homo sapiens_hsa047420.99424969
55Pyrimidine metabolism_Homo sapiens_hsa002400.99390158
56Retinol metabolism_Homo sapiens_hsa008300.98801648
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.98196984
58Fatty acid metabolism_Homo sapiens_hsa012120.96685395
59ABC transporters_Homo sapiens_hsa020100.87701724
60Type I diabetes mellitus_Homo sapiens_hsa049400.87323254
61N-Glycan biosynthesis_Homo sapiens_hsa005100.85883516
62Lysine degradation_Homo sapiens_hsa003100.84627537
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84386626
64Regulation of autophagy_Homo sapiens_hsa041400.84176114
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83679616
66Vitamin B6 metabolism_Homo sapiens_hsa007500.82902336
67Olfactory transduction_Homo sapiens_hsa047400.80726243
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79842503
69Fat digestion and absorption_Homo sapiens_hsa049750.79484090
70Asthma_Homo sapiens_hsa053100.74668579
71Base excision repair_Homo sapiens_hsa034100.74049089
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73430638
73Metabolic pathways_Homo sapiens_hsa011000.72363324
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70235323
75Glycerolipid metabolism_Homo sapiens_hsa005610.68947641
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67424258
77Parkinsons disease_Homo sapiens_hsa050120.66452770
78Glutathione metabolism_Homo sapiens_hsa004800.62320603
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53685861
80p53 signaling pathway_Homo sapiens_hsa041150.53167129
81Ovarian steroidogenesis_Homo sapiens_hsa049130.50373462
82Pyruvate metabolism_Homo sapiens_hsa006200.49428681
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49147596
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48769498
85Vitamin digestion and absorption_Homo sapiens_hsa049770.47197220
86Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46208439
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.42346906
88Insulin secretion_Homo sapiens_hsa049110.41153418
89Allograft rejection_Homo sapiens_hsa053300.38825354
90Collecting duct acid secretion_Homo sapiens_hsa049660.34526277
91Autoimmune thyroid disease_Homo sapiens_hsa053200.34219616
92Oocyte meiosis_Homo sapiens_hsa041140.32867174
93Huntingtons disease_Homo sapiens_hsa050160.32575323
94Renin-angiotensin system_Homo sapiens_hsa046140.31366292
95Serotonergic synapse_Homo sapiens_hsa047260.30042074
96Ribosome_Homo sapiens_hsa030100.28695047
97Circadian rhythm_Homo sapiens_hsa047100.26987630
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26857279
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.26184560
100Pancreatic secretion_Homo sapiens_hsa049720.26043732

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