ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	4.45039545
2	tryptophan catabolic process (GO:0006569)	4.24273405
3	indole-containing compound catabolic process (GO:0042436)	4.24273405
4	indolalkylamine catabolic process (GO:0046218)	4.24273405
5	response to pheromone (GO:0019236)	4.22433980
6	DNA deamination (GO:0045006)	4.17487716
7	drug catabolic process (GO:0042737)	4.09047080
8	behavioral response to nicotine (GO:0035095)	4.05889319
9	exogenous drug catabolic process (GO:0042738)	4.04024879
10	cytidine deamination (GO:0009972)	3.91628051
11	cytidine metabolic process (GO:0046087)	3.91628051
12	cytidine catabolic process (GO:0006216)	3.91628051
13	S-adenosylmethionine metabolic process (GO:0046500)	3.82445384
14	cellular ketone body metabolic process (GO:0046950)	3.76627605
15	indolalkylamine metabolic process (GO:0006586)	3.75071996
16	fucose catabolic process (GO:0019317)	3.62933088
17	L-fucose metabolic process (GO:0042354)	3.62933088
18	L-fucose catabolic process (GO:0042355)	3.62933088
19	kynurenine metabolic process (GO:0070189)	3.58246502
20	aromatic amino acid family catabolic process (GO:0009074)	3.58125523
21	tryptophan metabolic process (GO:0006568)	3.56747588
22	oxidative demethylation (GO:0070989)	3.54219944
23	amino acid salvage (GO:0043102)	3.39060039
24	L-methionine salvage (GO:0071267)	3.39060039
25	L-methionine biosynthetic process (GO:0071265)	3.39060039
26	ketone body metabolic process (GO:1902224)	3.36136614
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.35984848
28	sulfation (GO:0051923)	3.22319851
29	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.19845557
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.16086634
31	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13034505
32	respiratory chain complex IV assembly (GO:0008535)	3.11137813
33	regulation of hexokinase activity (GO:1903299)	3.08419471
34	regulation of glucokinase activity (GO:0033131)	3.08419471
35	axoneme assembly (GO:0035082)	3.08045794
36	nephron epithelium morphogenesis (GO:0072088)	3.06626267
37	nephron tubule morphogenesis (GO:0072078)	3.06626267
38	platelet dense granule organization (GO:0060155)	3.05085896
39	indole-containing compound metabolic process (GO:0042430)	3.04016812
40	xenobiotic catabolic process (GO:0042178)	3.01125294
41	dopamine transport (GO:0015872)	2.93947898
42	kidney morphogenesis (GO:0060993)	2.91395870
43	protein complex biogenesis (GO:0070271)	2.90283062
44	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.87491328
45	uronic acid metabolic process (GO:0006063)	2.87011615
46	glucuronate metabolic process (GO:0019585)	2.87011615
47	cellular biogenic amine catabolic process (GO:0042402)	2.86215976
48	amine catabolic process (GO:0009310)	2.86215976
49	nephron tubule formation (GO:0072079)	2.85448185
50	cytochrome complex assembly (GO:0017004)	2.84981368
51	preassembly of GPI anchor in ER membrane (GO:0016254)	2.84762246
52	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.83709156
53	L-phenylalanine catabolic process (GO:0006559)	2.83709156
54	gamma-aminobutyric acid transport (GO:0015812)	2.78834840
55	positive regulation of fatty acid transport (GO:2000193)	2.77852488
56	benzene-containing compound metabolic process (GO:0042537)	2.77473850
57	cellular glucuronidation (GO:0052695)	2.77062666
58	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.74010403
59	glyoxylate metabolic process (GO:0046487)	2.73880609
60	aromatic amino acid family metabolic process (GO:0009072)	2.67796234
61	detection of light stimulus involved in sensory perception (GO:0050962)	2.67122067
62	detection of light stimulus involved in visual perception (GO:0050908)	2.67122067
63	protein-cofactor linkage (GO:0018065)	2.65977974
64	reflex (GO:0060004)	2.63963521
65	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.63371546
66	methionine biosynthetic process (GO:0009086)	2.61730705
67	negative regulation of telomere maintenance (GO:0032205)	2.61333345
68	mitochondrial respiratory chain complex assembly (GO:0033108)	2.57708822
69	bile acid biosynthetic process (GO:0006699)	2.57691142
70	basic amino acid transport (GO:0015802)	2.57043468
71	alkaloid metabolic process (GO:0009820)	2.56202873
72	signal peptide processing (GO:0006465)	2.55424530
73	renal tubule morphogenesis (GO:0061333)	2.53477185
74	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.53018551
75	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.53018551
76	NADH dehydrogenase complex assembly (GO:0010257)	2.53018551
77	piRNA metabolic process (GO:0034587)	2.52645121
78	epoxygenase P450 pathway (GO:0019373)	2.52478981
79	negative regulation of mast cell activation (GO:0033004)	2.52431353
80	amino-acid betaine metabolic process (GO:0006577)	2.50753170
81	positive regulation of prostaglandin secretion (GO:0032308)	2.49900158
82	urate metabolic process (GO:0046415)	2.48782528
83	arginine metabolic process (GO:0006525)	2.48311509
84	embryonic epithelial tube formation (GO:0001838)	2.47274146
85	neuronal action potential (GO:0019228)	2.46474138
86	regulation of cilium movement (GO:0003352)	2.46256178
87	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.45669800
88	epithelial cilium movement (GO:0003351)	2.45032992
89	positive regulation of icosanoid secretion (GO:0032305)	2.44676520
90	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.43365021
91	endocrine pancreas development (GO:0031018)	2.42429435
92	transepithelial transport (GO:0070633)	2.42001906
93	GPI anchor metabolic process (GO:0006505)	2.40726680
94	drug metabolic process (GO:0017144)	2.38801667
95	aldehyde catabolic process (GO:0046185)	2.37467513
96	rhodopsin mediated signaling pathway (GO:0016056)	2.37232093
97	mannosylation (GO:0097502)	2.36951211
98	adaptation of signaling pathway (GO:0023058)	2.36387239
99	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.35703907
100	L-phenylalanine metabolic process (GO:0006558)	2.35703907

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.56185579
2	VDR_22108803_ChIP-Seq_LS180_Human	3.08159638
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.06692982
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.77898724
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.56157708
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45046070
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.43866049
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40696929
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.33946403
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.32357426
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.04398683
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.01772087
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.00316505
14	TAF15_26573619_Chip-Seq_HEK293_Human	1.98191794
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.96605021
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91624921
17	* P300_19829295_ChIP-Seq_ESCs_Human	1.90829344
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89848475
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.84477466
20	FUS_26573619_Chip-Seq_HEK293_Human	1.84344726
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.83665079
22	EWS_26573619_Chip-Seq_HEK293_Human	1.71724902
23	BCAT_22108803_ChIP-Seq_LS180_Human	1.69694579
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66315457
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.63259535
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60886393
27	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.60500474
28	CBP_20019798_ChIP-Seq_JUKART_Human	1.60500474
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.57912159
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.55913807
31	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55320583
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.50586397
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.48113537
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.45814157
35	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.45172565
36	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.43532786
37	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.43532786
38	STAT3_23295773_ChIP-Seq_U87_Human	1.41320768
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.41301540
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41120701
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.39567505
42	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37897133
43	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.37843229
44	AR_25329375_ChIP-Seq_VCAP_Human	1.36763217
45	* FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36581027
46	* FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36581027
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.36067779
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.33022181
49	* FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.32284438
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32253469
51	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.32170697
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.30252940
53	* TCF4_23295773_ChIP-Seq_U87_Human	1.29972061
54	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.29086353
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.28081275
56	NCOR_22424771_ChIP-Seq_293T_Human	1.27772034
57	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.27633246
58	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26523001
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26368047
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26095604
61	* AR_20517297_ChIP-Seq_VCAP_Human	1.25127569
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23713904
63	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.23426408
64	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22325766
65	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.19171117
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.17530204
67	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16084785
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.15929717
69	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.15838209
70	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14472576
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14421920
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.13580081
73	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13300721
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13080913
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.09733303
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.08383741
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.06865066
78	GATA3_26560356_Chip-Seq_TH2_Human	1.06363986
79	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05668989
80	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05260673
81	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05156847
82	REST_21632747_ChIP-Seq_MESCs_Mouse	1.05130546
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.04517281
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.03375526
85	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.03354359
86	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02647840
87	MYC_18940864_ChIP-ChIP_HL60_Human	1.02303922
88	HTT_18923047_ChIP-ChIP_STHdh_Human	1.02241552
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01958300
90	* HOXB7_26014856_ChIP-Seq_BT474_Human	1.00896996
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00000238
92	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98612792
93	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98184339
94	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.98184339
95	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.97930522
96	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97740756
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.97542322
98	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97341119
99	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.96535998
100	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.96238673

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.26977212
2	MP0002138_abnormal_hepatobiliary_system	4.80250473
3	MP0002139_abnormal_hepatobiliary_system	3.62647027
4	MP0003252_abnormal_bile_duct	3.27868799
5	MP0008875_abnormal_xenobiotic_pharmacok	2.74989796
6	MP0004043_abnormal_pH_regulation	2.67527425
7	MP0010386_abnormal_urinary_bladder	2.62167266
8	MP0002876_abnormal_thyroid_physiology	2.58272015
9	MP0005085_abnormal_gallbladder_physiolo	2.31480767
10	MP0002163_abnormal_gland_morphology	2.30167774
11	MP0005365_abnormal_bile_salt	2.25585552
12	MP0008872_abnormal_physiological_respon	2.17349809
13	MP0002928_abnormal_bile_duct	2.13968815
14	MP0002102_abnormal_ear_morphology	2.07442833
15	MP0002837_dystrophic_cardiac_calcinosis	2.04075118
16	MP0002638_abnormal_pupillary_reflex	2.02657476
17	MP0005379_endocrine/exocrine_gland_phen	2.00148842
18	MP0005360_urolithiasis	1.99894814
19	MP0005084_abnormal_gallbladder_morpholo	1.91659885
20	MP0005551_abnormal_eye_electrophysiolog	1.81218641
21	MP0003011_delayed_dark_adaptation	1.77809726
22	MP0008877_abnormal_DNA_methylation	1.72756329
23	MP0006072_abnormal_retinal_apoptosis	1.71827051
24	MP0005645_abnormal_hypothalamus_physiol	1.65379498
25	MP0003646_muscle_fatigue	1.60660626
26	MP0005332_abnormal_amino_acid	1.51623786
27	MP0003283_abnormal_digestive_organ	1.51538182
28	MP0005671_abnormal_response_to	1.47324448
29	MP0003136_yellow_coat_color	1.45851868
30	MP0005220_abnormal_exocrine_pancreas	1.43654623
31	MP0004133_heterotaxia	1.38928332
32	MP0005253_abnormal_eye_physiology	1.36830787
33	MP0005646_abnormal_pituitary_gland	1.36820211
34	MP0001968_abnormal_touch/_nociception	1.36584686
35	MP0004142_abnormal_muscle_tone	1.36313620
36	MP0001501_abnormal_sleep_pattern	1.33273357
37	MP0009745_abnormal_behavioral_response	1.31298631
38	MP0000427_abnormal_hair_cycle	1.30934066
39	MP0002277_abnormal_respiratory_mucosa	1.24609069
40	MP0000372_irregular_coat_pigmentation	1.24328822
41	MP0001756_abnormal_urination	1.22387868
42	MP0010329_abnormal_lipoprotein_level	1.20581374
43	MP0000569_abnormal_digit_pigmentation	1.19667480
44	MP0004885_abnormal_endolymph	1.17730027
45	MP0001986_abnormal_taste_sensitivity	1.16473408
46	MP0006276_abnormal_autonomic_nervous	1.14220714
47	MP0004019_abnormal_vitamin_homeostasis	1.13962267
48	MP0001485_abnormal_pinna_reflex	1.13960616
49	MP0000383_abnormal_hair_follicle	1.12278758
50	MP0009046_muscle_twitch	1.11313352
51	MP0003787_abnormal_imprinting	1.10981135
52	MP0002693_abnormal_pancreas_physiology	1.10280150
53	MP0001984_abnormal_olfaction	1.09962263
54	MP0001944_abnormal_pancreas_morphology	1.04231707
55	MP0002272_abnormal_nervous_system	1.04058043
56	MP0009643_abnormal_urine_homeostasis	1.02315237
57	MP0004145_abnormal_muscle_electrophysio	1.00693071
58	MP0000631_abnormal_neuroendocrine_gland	0.97665257
59	MP0001764_abnormal_homeostasis	0.97410445
60	MP0002736_abnormal_nociception_after	0.97194588
61	MP0001765_abnormal_ion_homeostasis	0.95930603
62	MP0005636_abnormal_mineral_homeostasis	0.95258426
63	MP0005174_abnormal_tail_pigmentation	0.95009088
64	MP0004147_increased_porphyrin_level	0.94646986
65	MP0010678_abnormal_skin_adnexa	0.92862126
66	MP0001905_abnormal_dopamine_level	0.92264480
67	MP0001666_abnormal_nutrient_absorption	0.90295269
68	MP0006292_abnormal_olfactory_placode	0.89741308
69	MP0000538_abnormal_urinary_bladder	0.89226379
70	MP0000230_abnormal_systemic_arterial	0.89188104
71	MP0002938_white_spotting	0.88004142
72	MP0001919_abnormal_reproductive_system	0.87371277
73	MP0009785_altered_susceptibility_to	0.86038587
74	MP0005075_abnormal_melanosome_morpholog	0.85482432
75	MP0000647_abnormal_sebaceous_gland	0.84933076
76	MP0001873_stomach_inflammation	0.82736473
77	MP0004742_abnormal_vestibular_system	0.80756526
78	MP0003880_abnormal_central_pattern	0.80686999
79	MP0002735_abnormal_chemical_nociception	0.80216614
80	MP0005389_reproductive_system_phenotype	0.79707464
81	MP0001486_abnormal_startle_reflex	0.78688981
82	MP0001970_abnormal_pain_threshold	0.78094413
83	MP0002557_abnormal_social/conspecific_i	0.77845476
84	MP0002136_abnormal_kidney_physiology	0.76896981
85	MP0002733_abnormal_thermal_nociception	0.74084235
86	MP0002909_abnormal_adrenal_gland	0.73721521
87	MP0003045_fibrosis	0.72693874
88	MP0005410_abnormal_fertilization	0.72206748
89	MP0002168_other_aberrant_phenotype	0.72107454
90	MP0004924_abnormal_behavior	0.71400307
91	MP0005386_behavior/neurological_phenoty	0.71400307
92	MP0005195_abnormal_posterior_eye	0.69305907
93	MP0000685_abnormal_immune_system	0.68300067
94	MP0005377_hearing/vestibular/ear_phenot	0.66338038
95	MP0003878_abnormal_ear_physiology	0.66338038
96	MP0000026_abnormal_inner_ear	0.65266069
97	MP0002064_seizures	0.65179334
98	MP0002118_abnormal_lipid_homeostasis	0.63696750
99	MP0001529_abnormal_vocalization	0.63641700
100	MP0002572_abnormal_emotion/affect_behav	0.63630596

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.44322765
2	Abnormality of the renal cortex (HP:0011035)	3.69372110
3	True hermaphroditism (HP:0010459)	3.60218826
4	Pancreatic fibrosis (HP:0100732)	3.51060746
5	Congenital stationary night blindness (HP:0007642)	3.45354629
6	Molar tooth sign on MRI (HP:0002419)	3.31386667
7	Abnormality of midbrain morphology (HP:0002418)	3.31386667
8	Hypomagnesemia (HP:0002917)	3.16592469
9	Metabolic alkalosis (HP:0200114)	3.13591797
10	Abnormality of the renal medulla (HP:0100957)	3.11595617
11	Tubular atrophy (HP:0000092)	3.10345443
12	Attenuation of retinal blood vessels (HP:0007843)	3.06278700
13	Polyuria (HP:0000103)	3.04499159
14	Nephronophthisis (HP:0000090)	3.00089192
15	Abnormal drinking behavior (HP:0030082)	2.95062250
16	Polydipsia (HP:0001959)	2.95062250
17	Medial flaring of the eyebrow (HP:0010747)	2.91005446
18	Increased circulating renin level (HP:0000848)	2.74204466
19	Hypokalemic alkalosis (HP:0001949)	2.71840596
20	Glycosuria (HP:0003076)	2.67538157
21	Abnormality of urine glucose concentration (HP:0011016)	2.67538157
22	Abnormal urine output (HP:0012590)	2.67305758
23	Abolished electroretinogram (ERG) (HP:0000550)	2.65191724
24	Hypothermia (HP:0002045)	2.64963956
25	Cystic liver disease (HP:0006706)	2.63664293
26	Large for gestational age (HP:0001520)	2.58888698
27	Renal cortical cysts (HP:0000803)	2.57290477
28	Aplasia/hypoplasia of the uterus (HP:0008684)	2.56196874
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.55679066
30	Abnormality of alanine metabolism (HP:0010916)	2.54843039
31	Hyperalaninemia (HP:0003348)	2.54843039
32	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54843039
33	Hypoplasia of the uterus (HP:0000013)	2.54819638
34	Chronic hepatic failure (HP:0100626)	2.54521236
35	Acute necrotizing encephalopathy (HP:0006965)	2.53060277
36	Mitochondrial inheritance (HP:0001427)	2.51158852
37	3-Methylglutaconic aciduria (HP:0003535)	2.50987179
38	Abnormality of renal excretion (HP:0011036)	2.50313343
39	Pendular nystagmus (HP:0012043)	2.49876362
40	Gaze-evoked nystagmus (HP:0000640)	2.45908199
41	Potter facies (HP:0002009)	2.45296599
42	Facial shape deformation (HP:0011334)	2.45296599
43	Type II lissencephaly (HP:0007260)	2.37956142
44	Lipid accumulation in hepatocytes (HP:0006561)	2.34039586
45	Abnormality of magnesium homeostasis (HP:0004921)	2.31791251
46	Hyperventilation (HP:0002883)	2.29856606
47	Methylmalonic acidemia (HP:0002912)	2.28643230
48	Abnormality of chloride homeostasis (HP:0011422)	2.28010723
49	Acute encephalopathy (HP:0006846)	2.28006843
50	Progressive macrocephaly (HP:0004481)	2.27500921
51	Alkalosis (HP:0001948)	2.24912265
52	Increased CSF lactate (HP:0002490)	2.21737837
53	Increased hepatocellular lipid droplets (HP:0006565)	2.21594784
54	Abnormal biliary tract physiology (HP:0012439)	2.17470361
55	Bile duct proliferation (HP:0001408)	2.17470361
56	Decreased central vision (HP:0007663)	2.14449603
57	Methylmalonic aciduria (HP:0012120)	2.13270093
58	IgG deficiency (HP:0004315)	2.12565377
59	Keratoconus (HP:0000563)	2.10610186
60	Increased corneal curvature (HP:0100692)	2.10610186
61	Abnormal mitochondria in muscle tissue (HP:0008316)	2.10535566
62	Tubulointerstitial fibrosis (HP:0005576)	2.09523035
63	Nephrogenic diabetes insipidus (HP:0009806)	2.05232528
64	Optic disc pallor (HP:0000543)	2.02125162
65	Gait imbalance (HP:0002141)	2.02064530
66	Hypoalbuminemia (HP:0003073)	2.01000940
67	Abnormal albumin level (HP:0012116)	2.01000940
68	Congenital sensorineural hearing impairment (HP:0008527)	1.99973430
69	Renal Fanconi syndrome (HP:0001994)	1.99423986
70	Abnormality of renin-angiotensin system (HP:0000847)	1.99332295
71	Ketosis (HP:0001946)	1.98513365
72	Congenital primary aphakia (HP:0007707)	1.98340999
73	Congenital hepatic fibrosis (HP:0002612)	1.97873846
74	Hyperglycinuria (HP:0003108)	1.96990709
75	Thyroiditis (HP:0100646)	1.96593145
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95821314
77	Hyperaldosteronism (HP:0000859)	1.93207113
78	Congenital, generalized hypertrichosis (HP:0004540)	1.92736449
79	Generalized aminoaciduria (HP:0002909)	1.92108016
80	Furrowed tongue (HP:0000221)	1.91843244
81	Tetany (HP:0001281)	1.89930436
82	Chorioretinal atrophy (HP:0000533)	1.89005665
83	Hypoproteinemia (HP:0003075)	1.87505540
84	Stomach cancer (HP:0012126)	1.87119315
85	Male pseudohermaphroditism (HP:0000037)	1.85876659
86	Abnormality of vitamin B metabolism (HP:0004340)	1.84929727
87	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.84908378
88	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84455868
89	Abnormality of renal resorption (HP:0011038)	1.83914551
90	Hepatocellular necrosis (HP:0001404)	1.83897204
91	Hyperphosphaturia (HP:0003109)	1.83708370
92	Sclerocornea (HP:0000647)	1.82802874
93	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.82524793
94	Abnormality of glycine metabolism (HP:0010895)	1.81157152
95	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81157152
96	Genital tract atresia (HP:0001827)	1.79976333
97	Renal salt wasting (HP:0000127)	1.79638997
98	Ketoacidosis (HP:0001993)	1.78869377
99	Bony spicule pigmentary retinopathy (HP:0007737)	1.78362885
100	Hydroxyprolinuria (HP:0003080)	1.77944411

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.26936692
2	WNK3	4.08558100
3	ADRBK2	3.05581481
4	TAOK3	2.80051727
5	TLK1	2.61441269
6	OXSR1	2.61366054
7	WNK4	2.56977031
8	GRK1	2.47488451
9	MAP4K2	2.46044846
10	PINK1	2.35473330
11	BMPR1B	2.31398169
12	TXK	2.29107698
13	ACVR1B	2.21559880
14	ZAK	2.21053687
15	NUAK1	2.09075781
16	LMTK2	1.96649648
17	INSRR	1.89153644
18	STK39	1.74539530
19	DAPK2	1.70762175
20	MAP3K4	1.60036165
21	CASK	1.53913194
22	MST4	1.51662031
23	TAF1	1.51234091
24	BCKDK	1.28572057
25	TNIK	1.20143281
26	ITK	1.13633248
27	MAPK13	1.11975343
28	FGFR2	1.10389157
29	BCR	1.10022460
30	MAP3K12	1.08542125
31	STK38L	1.03714815
32	PRKCQ	0.99543161
33	PAK3	0.98982195
34	KDR	0.98295668
35	PRKCE	0.95358333
36	IKBKB	0.93846711
37	ERBB3	0.91859257
38	MAP2K7	0.91270238
39	MAP2K6	0.90086996
40	VRK1	0.89864910
41	MUSK	0.89413223
42	ADRBK1	0.87911907
43	TEC	0.81899001
44	PHKG2	0.78582207
45	PHKG1	0.78582207
46	MAPKAPK3	0.78114095
47	CAMKK2	0.76054388
48	TRIM28	0.74880296
49	TNK2	0.73353407
50	NTRK3	0.72201896
51	STK16	0.71974739
52	DYRK2	0.70958142
53	VRK2	0.69485699
54	PASK	0.68887208
55	PIK3CA	0.67324976
56	PRKCG	0.66689009
57	MAP4K1	0.61774933
58	CSNK1G1	0.59551902
59	LIMK1	0.58834922
60	IKBKE	0.58183833
61	KIT	0.55358196
62	IRAK1	0.54939218
63	NLK	0.54056652
64	TRPM7	0.52459449
65	PTK2B	0.50599377
66	CSNK1G2	0.50569483
67	GRK7	0.49364604
68	MKNK2	0.48752431
69	SYK	0.48492414
70	PLK2	0.48389752
71	PRKACA	0.47878370
72	CHUK	0.47319922
73	MAPK15	0.47310772
74	CSNK1G3	0.46793511
75	TIE1	0.46587367
76	BMPR2	0.46565688
77	RPS6KA5	0.44780557
78	SGK2	0.44725241
79	PRKCI	0.44572174
80	TGFBR1	0.43559068
81	NME1	0.43544310
82	MARK1	0.42069897
83	FER	0.41655007
84	CSNK1A1	0.40351927
85	PRKCA	0.40306520
86	PRKAA2	0.39513780
87	CAMK2A	0.38363764
88	EPHA3	0.38119854
89	IGF1R	0.37616211
90	EIF2AK3	0.37139499
91	ROCK1	0.36354616
92	STK11	0.35526953
93	PRKG1	0.35399082
94	LCK	0.34010561
95	DAPK1	0.33964999
96	PRKAA1	0.33190510
97	PKN1	0.32716350
98	CSNK1A1L	0.32570918
99	STK3	0.31065794
100	MAPKAPK5	0.30471988

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.93466205
2	Caffeine metabolism_Homo sapiens_hsa00232	2.71659337
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.60339306
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.55854656
5	Butanoate metabolism_Homo sapiens_hsa00650	2.48973517
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.44779866
7	Nitrogen metabolism_Homo sapiens_hsa00910	2.31553561
8	Retinol metabolism_Homo sapiens_hsa00830	2.24552892
9	Phototransduction_Homo sapiens_hsa04744	2.23451099
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.14254632
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.11815703
12	Protein export_Homo sapiens_hsa03060	2.05285372
13	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.04673482
14	Oxidative phosphorylation_Homo sapiens_hsa00190	2.01879211
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.98738439
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93701437
17	Chemical carcinogenesis_Homo sapiens_hsa05204	1.88423289
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.85273755
19	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.84194376
20	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.82964673
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.80598155
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.72201705
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.70611373
24	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.63945904
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.61834672
26	Peroxisome_Homo sapiens_hsa04146	1.56589326
27	Propanoate metabolism_Homo sapiens_hsa00640	1.54348351
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.51728408
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.40798913
30	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40736022
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.37855697
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36292425
33	Parkinsons disease_Homo sapiens_hsa05012	1.35456354
34	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27864083
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.27239208
36	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25809552
37	ABC transporters_Homo sapiens_hsa02010	1.21432483
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.16531663
39	Basal transcription factors_Homo sapiens_hsa03022	1.10657861
40	Sulfur metabolism_Homo sapiens_hsa00920	1.06580062
41	Fatty acid degradation_Homo sapiens_hsa00071	1.06537454
42	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06114733
43	Type I diabetes mellitus_Homo sapiens_hsa04940	1.05571319
44	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.04407129
45	RNA polymerase_Homo sapiens_hsa03020	0.99287049
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.99041927
47	Complement and coagulation cascades_Homo sapiens_hsa04610	0.98166155
48	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94474834
49	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.93153485
50	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.92893174
51	Allograft rejection_Homo sapiens_hsa05330	0.92577791
52	Graft-versus-host disease_Homo sapiens_hsa05332	0.92522189
53	Histidine metabolism_Homo sapiens_hsa00340	0.91459677
54	Nicotine addiction_Homo sapiens_hsa05033	0.87928797
55	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83110639
56	Tyrosine metabolism_Homo sapiens_hsa00350	0.82200013
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81908080
58	One carbon pool by folate_Homo sapiens_hsa00670	0.81791140
59	Asthma_Homo sapiens_hsa05310	0.81635765
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.80771602
61	Bile secretion_Homo sapiens_hsa04976	0.79612438
62	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78673490
63	Taste transduction_Homo sapiens_hsa04742	0.75349158
64	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74197773
65	Alzheimers disease_Homo sapiens_hsa05010	0.73345732
66	Proteasome_Homo sapiens_hsa03050	0.72860847
67	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.72344694
68	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.71460552
69	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.69555322
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67171613
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.66782106
72	Homologous recombination_Homo sapiens_hsa03440	0.66568379
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.66560976
74	Insulin secretion_Homo sapiens_hsa04911	0.66461288
75	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.66452680
76	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66361709
77	Metabolic pathways_Homo sapiens_hsa01100	0.65982679
78	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.64826459
79	Huntingtons disease_Homo sapiens_hsa05016	0.64138565
80	Circadian rhythm_Homo sapiens_hsa04710	0.63638411
81	Serotonergic synapse_Homo sapiens_hsa04726	0.61719918
82	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59328658
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.58682084
84	RNA degradation_Homo sapiens_hsa03018	0.56408130
85	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56024764
86	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.54957073
87	Regulation of autophagy_Homo sapiens_hsa04140	0.53871842
88	Morphine addiction_Homo sapiens_hsa05032	0.52962628
89	Olfactory transduction_Homo sapiens_hsa04740	0.51990194
90	GABAergic synapse_Homo sapiens_hsa04727	0.51764028
91	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.48681038
92	Fanconi anemia pathway_Homo sapiens_hsa03460	0.48217512
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45729849
94	Mineral absorption_Homo sapiens_hsa04978	0.42458838
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.39414078
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39009355
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.38737086
98	Fatty acid metabolism_Homo sapiens_hsa01212	0.37532771
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.36807634
100	Salivary secretion_Homo sapiens_hsa04970	0.30823660

C14ORF105

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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