ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle maturation (GO:0016188)	5.77808021
2	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.31093140
3	regulation of short-term neuronal synaptic plasticity (GO:0048172)	5.23849142
4	glutamate secretion (GO:0014047)	5.16344696
5	postsynaptic membrane organization (GO:0001941)	5.05653634
6	neuron cell-cell adhesion (GO:0007158)	4.89505023
7	vocalization behavior (GO:0071625)	4.76568040
8	regulation of synaptic vesicle exocytosis (GO:2000300)	4.73063988
9	synaptic vesicle exocytosis (GO:0016079)	4.70484927
10	pyrimidine nucleobase catabolic process (GO:0006208)	4.59944661
11	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.57052835
12	presynaptic membrane assembly (GO:0097105)	4.47999814
13	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.45757841
14	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.40057226
15	neurotransmitter secretion (GO:0007269)	4.34624171
16	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.30900937
17	dendritic spine morphogenesis (GO:0060997)	4.30182281
18	presynaptic membrane organization (GO:0097090)	4.30041492
19	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.13252234
20	cellular potassium ion homeostasis (GO:0030007)	4.10193465
21	regulation of synaptic vesicle transport (GO:1902803)	4.09919723
22	protein localization to synapse (GO:0035418)	4.07050699
23	locomotory exploration behavior (GO:0035641)	4.05702792
24	axonal fasciculation (GO:0007413)	3.96014781
25	cell migration in hindbrain (GO:0021535)	3.95468951
26	auditory behavior (GO:0031223)	3.94239110
27	regulation of synapse structural plasticity (GO:0051823)	3.93785111
28	neuron recognition (GO:0008038)	3.86794022
29	neurotransmitter-gated ion channel clustering (GO:0072578)	3.86704262
30	nucleobase catabolic process (GO:0046113)	3.77719596
31	synaptic transmission, glutamatergic (GO:0035249)	3.75899494
32	regulation of neuronal synaptic plasticity (GO:0048168)	3.73855432
33	exploration behavior (GO:0035640)	3.73610092
34	cerebellar granule cell differentiation (GO:0021707)	3.73166182
35	glutamate receptor signaling pathway (GO:0007215)	3.69903341
36	gamma-aminobutyric acid transport (GO:0015812)	3.66439124
37	neuronal ion channel clustering (GO:0045161)	3.65854275
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.64479619
39	positive regulation of synapse maturation (GO:0090129)	3.61347984
40	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.58358257
41	sodium ion export (GO:0071436)	3.53267619
42	transmission of nerve impulse (GO:0019226)	3.53190333
43	regulation of glutamate receptor signaling pathway (GO:1900449)	3.45492945
44	neuronal action potential propagation (GO:0019227)	3.44154801
45	neurotransmitter transport (GO:0006836)	3.42481517
46	layer formation in cerebral cortex (GO:0021819)	3.39108896
47	synapse assembly (GO:0007416)	3.37214133
48	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.35703424
49	neuron-neuron synaptic transmission (GO:0007270)	3.35344549
50	establishment of mitochondrion localization (GO:0051654)	3.34353715
51	neuromuscular synaptic transmission (GO:0007274)	3.29305195
52	positive regulation of synapse assembly (GO:0051965)	3.27465973
53	response to auditory stimulus (GO:0010996)	3.26118435
54	regulation of neurotransmitter levels (GO:0001505)	3.22661456
55	axon ensheathment in central nervous system (GO:0032291)	3.22630259
56	central nervous system myelination (GO:0022010)	3.22630259
57	positive regulation of dendritic spine development (GO:0060999)	3.18706686
58	regulation of neurotransmitter secretion (GO:0046928)	3.16930497
59	synaptic vesicle endocytosis (GO:0048488)	3.16009303
60	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.15289751
61	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.13849793
62	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.13273427
63	positive regulation of membrane potential (GO:0045838)	3.13229433
64	mechanosensory behavior (GO:0007638)	3.10544719
65	dendrite morphogenesis (GO:0048813)	3.09330735
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.09145552
67	regulation of dendritic spine morphogenesis (GO:0061001)	3.08678783
68	regulation of postsynaptic membrane potential (GO:0060078)	3.06621591
69	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.06086811
70	central nervous system projection neuron axonogenesis (GO:0021952)	3.02406323
71	regulation of neurotransmitter transport (GO:0051588)	3.01932695
72	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.96260892
73	potassium ion homeostasis (GO:0055075)	2.95806125
74	regulation of vesicle fusion (GO:0031338)	2.95020185
75	dendritic spine organization (GO:0097061)	2.93598291
76	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.93489719
77	cell communication by electrical coupling (GO:0010644)	2.91572516
78	L-amino acid import (GO:0043092)	2.91187113
79	synapse organization (GO:0050808)	2.91062152
80	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.90165921
81	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.90089981
82	amino acid import (GO:0043090)	2.89448573
83	regulation of synapse maturation (GO:0090128)	2.87880313
84	regulation of respiratory system process (GO:0044065)	2.87384902
85	innervation (GO:0060384)	2.84656725
86	neuromuscular process controlling balance (GO:0050885)	2.83862023
87	regulation of synapse assembly (GO:0051963)	2.83248117
88	long-term memory (GO:0007616)	2.79833392
89	regulation of dendritic spine development (GO:0060998)	2.77254355
90	membrane depolarization (GO:0051899)	2.76985043
91	startle response (GO:0001964)	2.76358796
92	membrane depolarization during action potential (GO:0086010)	2.76340596
93	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.75499282
94	potassium ion import (GO:0010107)	2.75183243
95	positive regulation of neurotransmitter transport (GO:0051590)	2.72407313
96	regulation of synaptic plasticity (GO:0048167)	2.70480313
97	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.70170507
98	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.68283772
99	cerebellar Purkinje cell layer development (GO:0021680)	2.68181033
100	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.65797728

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.67784737
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.79178561
3	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.93679735
4	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.91487113
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.88701754
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.81797484
7	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.74656049
8	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.73998338
9	REST_21632747_ChIP-Seq_MESCs_Mouse	2.73993949
10	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.64307608
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.60660566
12	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.58842071
13	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.58842071
14	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.58276953
15	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.47462499
16	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.46696083
17	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.44955848
18	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.34313119
19	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.32604885
20	DROSHA_22980978_ChIP-Seq_HELA_Human	2.32510251
21	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.31788378
22	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.31332348
23	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.24963155
24	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.22713752
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.09121030
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.08932622
27	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.98173559
28	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.75056495
29	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.71903626
30	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.67845985
31	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.67303491
32	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67275088
33	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.66611775
34	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.65870624
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.62356041
36	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.61178148
37	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.45262019
38	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.44849392
39	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43932338
40	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.43578609
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.42634808
42	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.37276940
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32641465
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.32220699
45	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.31933958
46	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.31631396
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31428956
48	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.27981001
49	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.27226026
50	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.26781101
51	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26123935
52	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.23871837
53	AR_21572438_ChIP-Seq_LNCaP_Human	1.23247999
54	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23050015
55	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.21558921
56	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19775980
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19620469
58	AR_19668381_ChIP-Seq_PC3_Human	1.16407006
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16321885
60	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.14948418
61	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.14291916
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.13982314
63	* PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13456731
64	IGF1R_20145208_ChIP-Seq_DFB_Human	1.13315933
65	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.12458627
66	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.11070019
67	P300_19829295_ChIP-Seq_ESCs_Human	1.08680388
68	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.08203607
69	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07522215
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.05918186
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05918186
72	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.05227557
73	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.04165930
74	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.03130801
75	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.99939042
76	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.99796524
77	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99494271
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98206339
79	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.97859694
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.97252963
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96771705
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96016909
83	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.95223391
84	AR_25329375_ChIP-Seq_VCAP_Human	0.94576955
85	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.93299337
86	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.92737417
87	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.92314494
88	* ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.91987786
89	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.91651718
90	STAT3_23295773_ChIP-Seq_U87_Human	0.90327909
91	SOX9_26525672_Chip-Seq_HEART_Mouse	0.88594252
92	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.88103601
93	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87301974
94	* SMAD3_21741376_ChIP-Seq_ESCs_Human	0.86101780
95	KDM2B_26808549_Chip-Seq_K562_Human	0.85823384
96	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.85376814
97	* TCF4_23295773_ChIP-Seq_U87_Human	0.84262372
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.84227182
99	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.84103181
100	CTCF_27219007_Chip-Seq_Bcells_Human	0.81834337

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	5.05622142
2	MP0003880_abnormal_central_pattern	4.20122625
3	MP0004270_analgesia	3.94674625
4	MP0005423_abnormal_somatic_nervous	3.41833654
5	MP0003635_abnormal_synaptic_transmissio	3.25170445
6	MP0002064_seizures	2.70926861
7	MP0002734_abnormal_mechanical_nocicepti	2.67404919
8	MP0009745_abnormal_behavioral_response	2.66942014
9	MP0002063_abnormal_learning/memory/cond	2.66817682
10	MP0002822_catalepsy	2.58551560
11	MP0000778_abnormal_nervous_system	2.47027889
12	MP0002272_abnormal_nervous_system	2.39926880
13	MP0001486_abnormal_startle_reflex	2.31256563
14	MP0002572_abnormal_emotion/affect_behav	2.31225159
15	MP0002735_abnormal_chemical_nociception	2.28349664
16	MP0003122_maternal_imprinting	2.27852844
17	MP0009046_muscle_twitch	2.24946401
18	MP0001968_abnormal_touch/_nociception	2.16920971
19	MP0006276_abnormal_autonomic_nervous	2.01063626
20	MP0004885_abnormal_endolymph	1.95208501
21	MP0003787_abnormal_imprinting	1.88388086
22	MP0001984_abnormal_olfaction	1.78614738
23	MP0001970_abnormal_pain_threshold	1.77697878
24	MP0000955_abnormal_spinal_cord	1.74815050
25	MP0002638_abnormal_pupillary_reflex	1.74289323
26	MP0002557_abnormal_social/conspecific_i	1.72724791
27	MP0002184_abnormal_innervation	1.71701901
28	MP0002736_abnormal_nociception_after	1.71677391
29	MP0004811_abnormal_neuron_physiology	1.64719820
30	MP0009780_abnormal_chondrocyte_physiolo	1.64607855
31	MP0002733_abnormal_thermal_nociception	1.63117810
32	MP0003283_abnormal_digestive_organ	1.60317974
33	MP0008569_lethality_at_weaning	1.58050942
34	MP0002067_abnormal_sensory_capabilities	1.56960382
35	MP0001529_abnormal_vocalization	1.53238652
36	MP0002882_abnormal_neuron_morphology	1.51905811
37	MP0002909_abnormal_adrenal_gland	1.48699292
38	MP0003329_amyloid_beta_deposits	1.47408131
39	MP0005646_abnormal_pituitary_gland	1.40919756
40	MP0002653_abnormal_ependyma_morphology	1.38352733
41	MP0001501_abnormal_sleep_pattern	1.36836449
42	MP0001440_abnormal_grooming_behavior	1.34190145
43	MP0001502_abnormal_circadian_rhythm	1.33942314
44	MP0002066_abnormal_motor_capabilities/c	1.29146082
45	MP0002152_abnormal_brain_morphology	1.26249563
46	MP0005386_behavior/neurological_phenoty	1.26160101
47	MP0004924_abnormal_behavior	1.26160101
48	MP0001905_abnormal_dopamine_level	1.25270039
49	MP0003879_abnormal_hair_cell	1.20416621
50	MP0001188_hyperpigmentation	1.18837826
51	MP0003633_abnormal_nervous_system	1.18585903
52	MP0001177_atelectasis	1.14818765
53	MP0002751_abnormal_autonomic_nervous	1.14729226
54	MP0010386_abnormal_urinary_bladder	1.13497927
55	MP0001299_abnormal_eye_distance/	1.13169376
56	MP0003121_genomic_imprinting	1.12429788
57	MP0002102_abnormal_ear_morphology	1.09344145
58	MP0000566_synostosis	1.07154085
59	MP0005645_abnormal_hypothalamus_physiol	1.03956663
60	MP0003938_abnormal_ear_development	1.03889342
61	MP0004742_abnormal_vestibular_system	1.03200976
62	MP0004142_abnormal_muscle_tone	1.02832825
63	MP0003631_nervous_system_phenotype	1.01901657
64	MP0000631_abnormal_neuroendocrine_gland	1.00823220
65	MP0003861_abnormal_nervous_system	0.99606982
66	MP0002752_abnormal_somatic_nervous	0.97901256
67	MP0003634_abnormal_glial_cell	0.97835311
68	MP0003690_abnormal_glial_cell	0.96059290
69	MP0005499_abnormal_olfactory_system	0.95228661
70	MP0005394_taste/olfaction_phenotype	0.95228661
71	MP0001963_abnormal_hearing_physiology	0.94651407
72	MP0003136_yellow_coat_color	0.92935547
73	MP0004133_heterotaxia	0.92440007
74	MP0000026_abnormal_inner_ear	0.92125290
75	MP0002249_abnormal_larynx_morphology	0.87730045
76	MP0003123_paternal_imprinting	0.87116327
77	MP0002069_abnormal_eating/drinking_beha	0.86744942
78	MP0000534_abnormal_ureter_morphology	0.86482336
79	MP0003632_abnormal_nervous_system	0.85321686
80	MP0005551_abnormal_eye_electrophysiolog	0.83527118
81	MP0000920_abnormal_myelination	0.83173513
82	MP0000049_abnormal_middle_ear	0.82773654
83	MP0001485_abnormal_pinna_reflex	0.81962449
84	MP0001346_abnormal_lacrimal_gland	0.81603936
85	MP0002229_neurodegeneration	0.79831653
86	MP0005187_abnormal_penis_morphology	0.79470491
87	MP0003119_abnormal_digestive_system	0.72577142
88	MP0000569_abnormal_digit_pigmentation	0.71143708
89	MP0005248_abnormal_Harderian_gland	0.70895886
90	MP0005253_abnormal_eye_physiology	0.68477607
91	MP0003942_abnormal_urinary_system	0.67789058
92	MP0002081_perinatal_lethality	0.67026371
93	MP0000462_abnormal_digestive_system	0.66939022
94	MP0003137_abnormal_impulse_conducting	0.65722567
95	MP0001943_abnormal_respiration	0.65605889
96	MP0010770_preweaning_lethality	0.65207600
97	MP0002082_postnatal_lethality	0.65207600
98	MP0005503_abnormal_tendon_morphology	0.65073116
99	MP0010769_abnormal_survival	0.63857340
100	MP0001986_abnormal_taste_sensitivity	0.62774612

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	5.73631713
2	Focal motor seizures (HP:0011153)	5.43590483
3	Focal seizures (HP:0007359)	4.75521337
4	Febrile seizures (HP:0002373)	3.91686835
5	Epileptic encephalopathy (HP:0200134)	3.88699935
6	Action tremor (HP:0002345)	3.81089595
7	Atonic seizures (HP:0010819)	3.55539415
8	Limb dystonia (HP:0002451)	3.32559644
9	Generalized tonic-clonic seizures (HP:0002069)	3.20964634
10	Ankle clonus (HP:0011448)	3.12673253
11	Progressive cerebellar ataxia (HP:0002073)	3.07628700
12	Abnormal eating behavior (HP:0100738)	3.07530919
13	Hyperventilation (HP:0002883)	3.06369235
14	Supranuclear gaze palsy (HP:0000605)	2.99493001
15	Epileptiform EEG discharges (HP:0011182)	2.90274154
16	Drooling (HP:0002307)	2.90112475
17	Hemiparesis (HP:0001269)	2.83298522
18	Spastic gait (HP:0002064)	2.82372002
19	Polyphagia (HP:0002591)	2.79971723
20	Torticollis (HP:0000473)	2.74707437
21	Dialeptic seizures (HP:0011146)	2.74031969
22	EEG with generalized epileptiform discharges (HP:0011198)	2.72096967
23	Diplopia (HP:0000651)	2.67392850
24	Abnormality of binocular vision (HP:0011514)	2.67392850
25	Absence seizures (HP:0002121)	2.65872133
26	Amblyopia (HP:0000646)	2.61767839
27	Hypsarrhythmia (HP:0002521)	2.61479271
28	Excessive salivation (HP:0003781)	2.60863025
29	Sleep apnea (HP:0010535)	2.53233623
30	Abnormality of the corticospinal tract (HP:0002492)	2.46981384
31	Abnormality of the lower motor neuron (HP:0002366)	2.46672685
32	Urinary bladder sphincter dysfunction (HP:0002839)	2.45117289
33	Neurofibrillary tangles (HP:0002185)	2.44990251
34	Absent speech (HP:0001344)	2.42465909
35	Truncal ataxia (HP:0002078)	2.39370088
36	Urinary urgency (HP:0000012)	2.36841272
37	Akinesia (HP:0002304)	2.30079278
38	Impaired vibration sensation in the lower limbs (HP:0002166)	2.29090490
39	Intention tremor (HP:0002080)	2.27067187
40	Broad-based gait (HP:0002136)	2.26535934
41	Hypoventilation (HP:0002791)	2.25849305
42	Mutism (HP:0002300)	2.25069675
43	Megalencephaly (HP:0001355)	2.23955198
44	Obstructive sleep apnea (HP:0002870)	2.14077476
45	Insomnia (HP:0100785)	2.13917967
46	Focal dystonia (HP:0004373)	2.13497855
47	Gait imbalance (HP:0002141)	2.11986668
48	Hemiplegia (HP:0002301)	2.03488647
49	Lower limb muscle weakness (HP:0007340)	2.02845411
50	Anxiety (HP:0000739)	2.01005560
51	Status epilepticus (HP:0002133)	2.00074655
52	Split foot (HP:0001839)	1.98081215
53	Ulnar claw (HP:0001178)	1.96702911
54	Peripheral hypomyelination (HP:0007182)	1.94800882
55	Dysmetria (HP:0001310)	1.94285447
56	Craniofacial dystonia (HP:0012179)	1.94222368
57	Depression (HP:0000716)	1.93090773
58	Morphological abnormality of the pyramidal tract (HP:0002062)	1.91234770
59	Annular pancreas (HP:0001734)	1.90701559
60	Hypoplasia of the corpus callosum (HP:0002079)	1.88644767
61	Genetic anticipation (HP:0003743)	1.87057152
62	Pheochromocytoma (HP:0002666)	1.86085263
63	Agitation (HP:0000713)	1.85735914
64	Specific learning disability (HP:0001328)	1.84066536
65	Overriding aorta (HP:0002623)	1.82429438
66	Aplasia involving bones of the extremities (HP:0009825)	1.82396269
67	Aplasia involving bones of the upper limbs (HP:0009823)	1.82396269
68	Aplasia of the phalanges of the hand (HP:0009802)	1.82396269
69	Visual hallucinations (HP:0002367)	1.82331723
70	Heterochromia iridis (HP:0001100)	1.81767835
71	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.81264576
72	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.81264576
73	Spastic tetraplegia (HP:0002510)	1.81087102
74	Postural instability (HP:0002172)	1.79963031
75	Cerebral inclusion bodies (HP:0100314)	1.79736780
76	Bowel diverticulosis (HP:0005222)	1.79185323
77	Elfin facies (HP:0004428)	1.78251384
78	Failure to thrive in infancy (HP:0001531)	1.76327955
79	Abnormality of the diencephalon (HP:0010662)	1.75828162
80	Poor eye contact (HP:0000817)	1.74669238
81	Turricephaly (HP:0000262)	1.74324672
82	Cerebral hypomyelination (HP:0006808)	1.73700578
83	Neoplasm of the heart (HP:0100544)	1.73040135
84	Cutaneous finger syndactyly (HP:0010554)	1.72785712
85	Fetal akinesia sequence (HP:0001989)	1.72564520
86	Cortical dysplasia (HP:0002539)	1.72034801
87	Retinal dysplasia (HP:0007973)	1.70756936
88	Amyotrophic lateral sclerosis (HP:0007354)	1.69862516
89	Papilledema (HP:0001085)	1.67990462
90	Intestinal atresia (HP:0011100)	1.64094973
91	Hypoplasia of the brainstem (HP:0002365)	1.64090424
92	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.64090424
93	Bronchomalacia (HP:0002780)	1.63358960
94	Clonus (HP:0002169)	1.63307462
95	Poor suck (HP:0002033)	1.62483373
96	Impaired smooth pursuit (HP:0007772)	1.62373271
97	Impaired social interactions (HP:0000735)	1.62161477
98	Abnormal social behavior (HP:0012433)	1.62161477
99	Dysdiadochokinesis (HP:0002075)	1.61927153
100	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.61696702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	5.47051019
2	CASK	4.00301611
3	EPHA4	3.51752318
4	NTRK3	3.48681300
5	NTRK2	3.31194345
6	PAK6	2.75061756
7	DAPK2	2.55393255
8	NTRK1	2.34222134
9	MAP3K4	2.30753514
10	UHMK1	2.20669679
11	MINK1	1.93058111
12	MAP2K7	1.92082331
13	MAPK13	1.88113832
14	PRKD3	1.81274075
15	CAMKK1	1.72899642
16	DYRK2	1.58847475
17	SIK2	1.54189294
18	FGFR2	1.53964193
19	MAP3K9	1.45871814
20	PRKCG	1.44174804
21	PINK1	1.44136706
22	TYRO3	1.42757531
23	CDK5	1.39902138
24	PNCK	1.38316520
25	PHKG2	1.37048771
26	PHKG1	1.37048771
27	PLK2	1.35248351
28	SGK494	1.33697415
29	SGK223	1.33697415
30	LATS2	1.23202863
31	PAK3	1.22561713
32	CSNK1G2	1.19408164
33	BCR	1.19281582
34	CAMK2B	1.19185652
35	MAP2K4	1.14605825
36	WNK3	1.12990558
37	TNIK	1.03253943
38	RIPK1	1.02630196
39	DYRK1A	1.00970477
40	SGK2	0.97915032
41	PKN1	0.95072675
42	CDK15	0.93601112
43	CAMK1	0.93554468
44	CDK18	0.93223655
45	CAMK2A	0.90944116
46	GRK5	0.90259842
47	CDK14	0.89823186
48	CDK19	0.87378699
49	MAPK15	0.87257670
50	PRKCH	0.86771526
51	CDK11A	0.85229343
52	TRIM28	0.79196091
53	CAMK2G	0.77497800
54	CSNK1G3	0.77183254
55	EPHA3	0.75549559
56	LIMK1	0.75043627
57	EPHB2	0.73550011
58	KSR1	0.72774703
59	PRKCE	0.71849105
60	INSRR	0.71218716
61	MARK2	0.68292180
62	CSNK1A1L	0.68152462
63	PRKCZ	0.67965364
64	MAP4K2	0.66483926
65	RET	0.65052990
66	CAMKK2	0.64888360
67	STK38	0.64151185
68	CSNK1G1	0.63142342
69	NEK6	0.61736245
70	ROCK2	0.61138784
71	STK11	0.59243460
72	DAPK1	0.58219210
73	SGK3	0.57764610
74	CAMK2D	0.56903211
75	SGK1	0.55846467
76	DYRK1B	0.53830430
77	ERBB2	0.52477462
78	CAMK4	0.52045307
79	MAPK10	0.48374001
80	PDGFRA	0.46129235
81	RPS6KA3	0.45821701
82	ERBB3	0.44000849
83	PKN2	0.43568555
84	KSR2	0.43564610
85	ALK	0.43417472
86	BMPR1B	0.43175237
87	BRSK1	0.40963475
88	CAMK1G	0.40819810
89	CSNK1D	0.39571998
90	ROCK1	0.39265928
91	DDR2	0.39008987
92	CSNK1E	0.39008563
93	STK38L	0.37271480
94	ADRBK2	0.35931711
95	PRKAA1	0.34843285
96	PRKACA	0.34751236
97	PRKG1	0.34285241
98	FRK	0.32209671
99	RPS6KA2	0.31698238
100	LMTK2	0.30864061

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.19602455
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.17768308
3	GABAergic synapse_Homo sapiens_hsa04727	2.86452235
4	Circadian entrainment_Homo sapiens_hsa04713	2.66415909
5	Glutamatergic synapse_Homo sapiens_hsa04724	2.65264984
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.56362605
7	Morphine addiction_Homo sapiens_hsa05032	2.49628528
8	Insulin secretion_Homo sapiens_hsa04911	2.42118299
9	Amphetamine addiction_Homo sapiens_hsa05031	2.35303353
10	Cocaine addiction_Homo sapiens_hsa05030	2.25225137
11	Dopaminergic synapse_Homo sapiens_hsa04728	2.19863477
12	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	2.19766246
13	Long-term potentiation_Homo sapiens_hsa04720	1.93226151
14	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.90562432
15	Cholinergic synapse_Homo sapiens_hsa04725	1.83100865
16	Gastric acid secretion_Homo sapiens_hsa04971	1.74292139
17	Axon guidance_Homo sapiens_hsa04360	1.64390491
18	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.62662872
19	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.55522608
20	Taste transduction_Homo sapiens_hsa04742	1.52294435
21	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.51068970
22	Salivary secretion_Homo sapiens_hsa04970	1.43753319
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.43612763
24	cAMP signaling pathway_Homo sapiens_hsa04024	1.38742183
25	Long-term depression_Homo sapiens_hsa04730	1.38622292
26	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.37065876
27	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.33747488
28	Gap junction_Homo sapiens_hsa04540	1.32549850
29	Renin secretion_Homo sapiens_hsa04924	1.24394377
30	Melanogenesis_Homo sapiens_hsa04916	1.21684182
31	Serotonergic synapse_Homo sapiens_hsa04726	1.19064620
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.18694078
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.14875801
34	Type II diabetes mellitus_Homo sapiens_hsa04930	1.14021324
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.11950143
36	Estrogen signaling pathway_Homo sapiens_hsa04915	1.07467899
37	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.98502712
38	Phototransduction_Homo sapiens_hsa04744	0.96095152
39	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95998038
40	Olfactory transduction_Homo sapiens_hsa04740	0.91778718
41	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.91401512
42	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.91083246
43	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90992213
44	Vibrio cholerae infection_Homo sapiens_hsa05110	0.90198809
45	Hippo signaling pathway_Homo sapiens_hsa04390	0.89401154
46	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.89345006
47	GnRH signaling pathway_Homo sapiens_hsa04912	0.86925913
48	Glioma_Homo sapiens_hsa05214	0.86151701
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.85814682
50	ErbB signaling pathway_Homo sapiens_hsa04012	0.82958122
51	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.79507671
52	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.78951754
53	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.78516374
54	Oocyte meiosis_Homo sapiens_hsa04114	0.77465391
55	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.77389181
56	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.77199282
57	Pancreatic secretion_Homo sapiens_hsa04972	0.74829886
58	Wnt signaling pathway_Homo sapiens_hsa04310	0.74542139
59	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.73990327
60	Basal cell carcinoma_Homo sapiens_hsa05217	0.73439803
61	Rap1 signaling pathway_Homo sapiens_hsa04015	0.73271921
62	Bile secretion_Homo sapiens_hsa04976	0.72434965
63	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.72397465
64	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.72008488
65	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.70991912
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70531598
67	Ras signaling pathway_Homo sapiens_hsa04014	0.70064408
68	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68581302
69	Butanoate metabolism_Homo sapiens_hsa00650	0.67805746
70	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.67568165
71	Tight junction_Homo sapiens_hsa04530	0.67155323
72	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.66154193
73	Circadian rhythm_Homo sapiens_hsa04710	0.63711448
74	Alcoholism_Homo sapiens_hsa05034	0.61894349
75	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61092809
76	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.60904921
77	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58933814
78	MAPK signaling pathway_Homo sapiens_hsa04010	0.55334375
79	AMPK signaling pathway_Homo sapiens_hsa04152	0.53726380
80	Choline metabolism in cancer_Homo sapiens_hsa05231	0.52705180
81	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.51871017
82	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.51651385
83	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.48344654
84	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.46181609
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.45618164
86	Endometrial cancer_Homo sapiens_hsa05213	0.45366987
87	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.43123422
88	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.42279047
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.41545923
90	mTOR signaling pathway_Homo sapiens_hsa04150	0.40867298
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40019068
92	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.39504512
93	Prion diseases_Homo sapiens_hsa05020	0.36933786
94	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.36372396
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35949663
96	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.35533570
97	Alzheimers disease_Homo sapiens_hsa05010	0.35080268
98	Protein digestion and absorption_Homo sapiens_hsa04974	0.33929034
99	Endocytosis_Homo sapiens_hsa04144	0.30202210
100	Notch signaling pathway_Homo sapiens_hsa04330	0.28113570

C14ORF132

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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