C14ORF159

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.54780113
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.10879332
3negative regulation of cell killing (GO:0031342)4.95953619
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.95953619
5antigen processing and presentation of endogenous antigen (GO:0019883)4.79775658
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.46331410
7regulation of B cell receptor signaling pathway (GO:0050855)4.43509417
8regulation of gamma-delta T cell activation (GO:0046643)4.39648450
9regulation of gamma-delta T cell differentiation (GO:0045586)4.36383167
10positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.08727634
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.04398881
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.04398881
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.04398881
14modulation by symbiont of host immune response (GO:0052553)4.04398881
15positive regulation by symbiont of host defense response (GO:0052509)4.04398881
16modulation by symbiont of host defense response (GO:0052031)4.04398881
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.00635954
18immunoglobulin mediated immune response (GO:0016064)3.94900091
19detection of other organism (GO:0098543)3.82666293
20positive regulation of B cell differentiation (GO:0045579)3.82396948
21positive thymic T cell selection (GO:0045059)3.81099606
22detection of bacterium (GO:0016045)3.69583069
23B cell receptor signaling pathway (GO:0050853)3.63457028
24neutrophil activation involved in immune response (GO:0002283)3.60976733
25negative regulation of lymphocyte mediated immunity (GO:0002707)3.56109422
26cellular extravasation (GO:0045123)3.49755527
27microglial cell activation (GO:0001774)3.46939520
28negative thymic T cell selection (GO:0045060)3.38942798
29regulation of B cell differentiation (GO:0045577)3.37430398
30macrophage activation involved in immune response (GO:0002281)3.34395400
31muscle filament sliding (GO:0030049)3.34300044
32actin-myosin filament sliding (GO:0033275)3.34300044
33negative T cell selection (GO:0043383)3.32934431
34detection of external biotic stimulus (GO:0098581)3.28025250
35negative regulation of leukocyte mediated immunity (GO:0002704)3.27557233
36regulation of relaxation of muscle (GO:1901077)3.23698578
37negative regulation of T cell mediated immunity (GO:0002710)3.23578067
38negative regulation of interleukin-12 production (GO:0032695)3.21877167
39response to peptidoglycan (GO:0032494)3.21702744
40response to interleukin-15 (GO:0070672)3.17595798
41positive T cell selection (GO:0043368)3.16735491
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.12641238
43detection of molecule of bacterial origin (GO:0032490)3.08515174
44type I interferon signaling pathway (GO:0060337)3.04892476
45cellular response to type I interferon (GO:0071357)3.04892476
46response to type I interferon (GO:0034340)3.04450462
47interferon-gamma-mediated signaling pathway (GO:0060333)3.01735292
48response to host immune response (GO:0052572)2.98773661
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98773661
50response to interferon-beta (GO:0035456)2.98713220
51cellular response to interleukin-15 (GO:0071350)2.98040751
52positive regulation of antigen processing and presentation (GO:0002579)2.97286853
53regulation of mast cell degranulation (GO:0043304)2.95115810
54positive regulation of granulocyte differentiation (GO:0030854)2.93468571
55myeloid cell activation involved in immune response (GO:0002275)2.93459648
56leukocyte aggregation (GO:0070486)2.93158959
57regulation of antigen processing and presentation (GO:0002577)2.93038409
58positive regulation of mast cell activation (GO:0033005)2.90051794
59regulation of germinal center formation (GO:0002634)2.89886875
60negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.89433001
61B cell mediated immunity (GO:0019724)2.88210572
62macrophage activation (GO:0042116)2.84437559
63neutrophil activation (GO:0042119)2.83812178
64germinal center formation (GO:0002467)2.83774097
65regulation of mast cell activation (GO:0033003)2.81924703
66detection of biotic stimulus (GO:0009595)2.81032003
67response to muramyl dipeptide (GO:0032495)2.79598146
68regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77554518
69positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.77506701
70T cell selection (GO:0045058)2.77410875
71positive regulation of mast cell activation involved in immune response (GO:0033008)2.75585721
72positive regulation of mast cell degranulation (GO:0043306)2.75585721
73regulation of dendritic cell antigen processing and presentation (GO:0002604)2.75472800
74regulation of interferon-beta biosynthetic process (GO:0045357)2.75335136
75regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.73561236
76regulation of mast cell activation involved in immune response (GO:0033006)2.73504808
77positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.72744612
78regulation of T cell mediated cytotoxicity (GO:0001914)2.71834653
79T cell migration (GO:0072678)2.70400865
80cytidine metabolic process (GO:0046087)2.70289041
81cytidine catabolic process (GO:0006216)2.70289041
82cytidine deamination (GO:0009972)2.70289041
83negative regulation of innate immune response (GO:0045824)2.68645366
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.68280538
85respiratory burst (GO:0045730)2.68066505
86regulation of necroptotic process (GO:0060544)2.66440526
87leukocyte degranulation (GO:0043299)2.66093189
88regulation of skeletal muscle contraction (GO:0014819)2.66020971
89negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.64822695
90thymic T cell selection (GO:0045061)2.64147188
91mast cell activation (GO:0045576)2.64137691
92regulation of alpha-beta T cell proliferation (GO:0046640)2.63791916
93positive regulation of T cell mediated cytotoxicity (GO:0001916)2.61821986
94response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.61769506
95response to host (GO:0075136)2.61769506
96response to host defenses (GO:0052200)2.61769506
97regulation of granulocyte differentiation (GO:0030852)2.60841884
98creatine metabolic process (GO:0006600)2.60283410
99neutrophil mediated immunity (GO:0002446)2.59621687
100regulation of tolerance induction (GO:0002643)2.59015002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* IRF8_22096565_ChIP-ChIP_GC-B_Human6.32420325
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.91952923
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.74265319
4* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.53383524
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.06525899
6SCL_19346495_ChIP-Seq_HPC-7_Human2.94121408
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.84837149
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82558887
9RUNX_20019798_ChIP-Seq_JUKART_Human2.78194937
10RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44356984
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.39946865
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.37925600
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36197725
14LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.32311101
15* MYB_26560356_Chip-Seq_TH2_Human2.15866792
16* SPI1_23127762_ChIP-Seq_K562_Human2.13815585
17E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98942437
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.98233803
19LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.92256630
20VDR_24763502_ChIP-Seq_THP-1_Human1.91532420
21* SPI1_23547873_ChIP-Seq_NB4_Human1.89156295
22VDR_21846776_ChIP-Seq_THP-1_Human1.80262880
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78600093
24* MAF_26560356_Chip-Seq_TH1_Human1.75337674
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74747700
26GATA1_19941827_ChIP-Seq_MEL_Mouse1.73752670
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70756721
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68751556
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.67868974
30GATA3_27048872_Chip-Seq_THYMUS_Human1.67167173
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.63249552
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.61440252
33UTX_26944678_Chip-Seq_JUKART_Human1.58987078
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58885780
35GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.56545151
36VDR_24787735_ChIP-Seq_THP-1_Human1.56363669
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.55373221
38MYB_26560356_Chip-Seq_TH1_Human1.52269357
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51053135
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45376672
41GATA3_26560356_Chip-Seq_TH2_Human1.42801746
42GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40238551
43Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34628605
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.33726344
45MAF_26560356_Chip-Seq_TH2_Human1.32837738
46BCL6_27268052_Chip-Seq_Bcells_Human1.32559319
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29581876
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27520611
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.27240908
50GATA1_22025678_ChIP-Seq_K562_Human1.24431368
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23562559
52GATA1_19941826_ChIP-Seq_K562_Human1.22805826
53GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20252058
54DROSHA_22980978_ChIP-Seq_HELA_Human1.20097996
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17458935
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16215014
57SPI1_20517297_ChIP-Seq_HL60_Human1.15366810
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.15043843
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11522387
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.10745741
61PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09413781
62STAT1_20625510_ChIP-Seq_HELA_Human1.08752908
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08704091
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08510887
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06619106
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04919529
67BCOR_27268052_Chip-Seq_Bcells_Human1.04423571
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04217429
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02697087
70TCF7_22412390_ChIP-Seq_EML_Mouse1.02216347
71KDM2B_26808549_Chip-Seq_DND41_Human1.00512181
72BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99263524
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98007394
74CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97500745
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96188317
76MYC_22102868_ChIP-Seq_BL_Human0.95664460
77PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95070427
78* P300_27268052_Chip-Seq_Bcells_Human0.95003147
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94602578
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94128699
81PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92953426
82* ELF1_20517297_ChIP-Seq_JURKAT_Human0.89941838
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89704882
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89541019
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88996906
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88274735
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88247516
88GATA2_19941826_ChIP-Seq_K562_Human0.88032763
89PU_27001747_Chip-Seq_BMDM_Mouse0.87720605
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86742218
91GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86404313
92CIITA_25753668_ChIP-Seq_RAJI_Human0.86342270
93SMRT_27268052_Chip-Seq_Bcells_Human0.83456009
94RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82845585
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.82435652
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82007144
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81866827
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81708259
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.81157499
100TBX20_22080862_ChIP-Seq_HEART_Mouse0.81157499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.77737015
2MP0001835_abnormal_antigen_presentation3.26119039
3MP0003646_muscle_fatigue2.98798147
4MP0003436_decreased_susceptibility_to2.89780918
5MP0003303_peritoneal_inflammation2.54785879
6MP0005671_abnormal_response_to2.52296907
7MP0001800_abnormal_humoral_immune2.45755169
8MP0002419_abnormal_innate_immunity2.38013432
9MP0005025_abnormal_response_to2.31042651
10MP0005387_immune_system_phenotype2.27392431
11MP0001790_abnormal_immune_system2.27392431
12MP0000685_abnormal_immune_system2.26214387
13MP0005000_abnormal_immune_tolerance2.22358153
14MP0009785_altered_susceptibility_to2.22257181
15MP0004084_abnormal_cardiac_muscle2.14304015
16MP0003763_abnormal_thymus_physiology2.11353468
17MP0002723_abnormal_immune_serum2.11181426
18MP0002148_abnormal_hypersensitivity_rea2.05806534
19MP0004036_abnormal_muscle_relaxation2.05549137
20MP0002420_abnormal_adaptive_immunity2.04916072
21MP0003828_pulmonary_edema2.03004090
22MP0002452_abnormal_antigen_presenting2.01833384
23MP0001819_abnormal_immune_cell2.01461810
24MP0002837_dystrophic_cardiac_calcinosis1.93304289
25MP0005451_abnormal_body_composition1.82335135
26MP0005464_abnormal_platelet_physiology1.81067871
27MP0004130_abnormal_muscle_cell1.79258462
28MP0004145_abnormal_muscle_electrophysio1.76756201
29MP0000751_myopathy1.74614685
30MP0002332_abnormal_exercise_endurance1.67815046
31MP0003191_abnormal_cellular_cholesterol1.67186542
32MP0006082_CNS_inflammation1.60503333
33MP0002405_respiratory_system_inflammati1.55776142
34MP0000465_gastrointestinal_hemorrhage1.55733187
35MP0009278_abnormal_bone_marrow1.55190068
36MP0000716_abnormal_immune_system1.53038287
37MP0003172_abnormal_lysosome_physiology1.51843804
38MP0001533_abnormal_skeleton_physiology1.51136366
39MP0002398_abnormal_bone_marrow1.51124975
40MP0002396_abnormal_hematopoietic_system1.50052240
41MP0000749_muscle_degeneration1.49301443
42MP0009764_decreased_sensitivity_to1.49028281
43MP0002132_abnormal_respiratory_system1.46158627
44MP0004510_myositis1.45904109
45MP0010155_abnormal_intestine_physiology1.42094543
46MP0005397_hematopoietic_system_phenotyp1.41983362
47MP0001545_abnormal_hematopoietic_system1.41983362
48MP0008260_abnormal_autophagy1.39732823
49MP0001986_abnormal_taste_sensitivity1.38901162
50MP0004484_altered_response_of1.38622454
51MP0005330_cardiomyopathy1.34499833
52MP0000689_abnormal_spleen_morphology1.33069624
53MP0003075_altered_response_to1.32363497
54MP0001845_abnormal_inflammatory_respons1.31535752
55MP0004215_abnormal_myocardial_fiber1.30198653
56MP0003866_abnormal_defecation1.26671445
57MP0006036_abnormal_mitochondrial_physio1.25948251
58MP0002722_abnormal_immune_system1.23602712
59MP0008469_abnormal_protein_level1.21468726
60MP0002138_abnormal_hepatobiliary_system1.17318893
61MP0002429_abnormal_blood_cell1.17255419
62MP0003183_abnormal_peptide_metabolism1.17182399
63MP0005075_abnormal_melanosome_morpholog1.12670207
64MP0002106_abnormal_muscle_physiology1.12160229
65MP0003300_gastrointestinal_ulcer1.11740992
66MP0003690_abnormal_glial_cell1.10623841
67MP0002166_altered_tumor_susceptibility1.08480303
68MP0002972_abnormal_cardiac_muscle1.08279436
69MP0003806_abnormal_nucleotide_metabolis1.07700337
70MP0005167_abnormal_blood-brain_barrier1.04834265
71MP0000703_abnormal_thymus_morphology1.01520107
72MP0003045_fibrosis0.99684821
73MP0004087_abnormal_muscle_fiber0.99631853
74MP0009333_abnormal_splenocyte_physiolog0.99283003
75MP0005166_decreased_susceptibility_to0.98367147
76MP0002269_muscular_atrophy0.97422138
77MP0005620_abnormal_muscle_contractility0.96874461
78MP0003656_abnormal_erythrocyte_physiolo0.95354338
79MP0000343_altered_response_to0.95227415
80MP0008004_abnormal_stomach_pH0.95216188
81MP0001851_eye_inflammation0.95144575
82MP0004947_skin_inflammation0.94668321
83MP0005670_abnormal_white_adipose0.93875706
84MP0000604_amyloidosis0.93825867
85MP0005385_cardiovascular_system_phenoty0.91067164
86MP0001544_abnormal_cardiovascular_syste0.91067164
87MP0000747_muscle_weakness0.89602552
88MP0002933_joint_inflammation0.85832820
89MP0005058_abnormal_lysosome_morphology0.84466690
90MP0008775_abnormal_heart_ventricle0.84390179
91MP0005266_abnormal_metabolism0.84269426
92MP0002127_abnormal_cardiovascular_syste0.84259799
93MP0009763_increased_sensitivity_to0.81822692
94MP0001853_heart_inflammation0.81811777
95MP0005535_abnormal_body_temperature0.81379775
96MP0005369_muscle_phenotype0.81011032
97MP0002998_abnormal_bone_remodeling0.78992401
98MP0006138_congestive_heart_failure0.77748883
99MP0000759_abnormal_skeletal_muscle0.76255822
100MP0004883_abnormal_blood_vessel0.75929092

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.36373853
2Myositis (HP:0100614)4.30958394
3Eczematoid dermatitis (HP:0000976)4.08228269
4Exercise-induced myalgia (HP:0003738)3.86403108
5Recurrent abscess formation (HP:0002722)3.85609737
6Orchitis (HP:0100796)3.83573965
7Muscle fiber inclusion bodies (HP:0100299)3.70917718
8Recurrent bacterial skin infections (HP:0005406)3.69111288
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.66658557
10Stomatitis (HP:0010280)3.66220255
11Nemaline bodies (HP:0003798)3.65197545
12Retrobulbar optic neuritis (HP:0100654)3.61339608
13Optic neuritis (HP:0100653)3.61339608
14Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.54879365
15Recurrent fungal infections (HP:0002841)3.51732986
16Recurrent gram-negative bacterial infections (HP:0005420)3.50987276
17Meningitis (HP:0001287)3.30886550
18Muscle fiber splitting (HP:0003555)3.25711474
19Mediastinal lymphadenopathy (HP:0100721)3.18862372
20Sudden death (HP:0001699)3.16367948
21Recurrent cutaneous fungal infections (HP:0011370)3.16047304
22Chronic mucocutaneous candidiasis (HP:0002728)3.16047304
23Panhypogammaglobulinemia (HP:0003139)3.11125142
24Chest pain (HP:0100749)3.10661868
25Agammaglobulinemia (HP:0004432)2.99806301
26Abnormality of macrophages (HP:0004311)2.96635993
27Obstructive lung disease (HP:0006536)2.96102784
28Chronic obstructive pulmonary disease (HP:0006510)2.96102784
29Hyporeflexia of lower limbs (HP:0002600)2.93596057
30Asymmetric septal hypertrophy (HP:0001670)2.84516121
31Recurrent skin infections (HP:0001581)2.81014010
32Rhabdomyolysis (HP:0003201)2.81012601
33Encephalitis (HP:0002383)2.80437107
34Vasculitis (HP:0002633)2.77353615
35EMG: myopathic abnormalities (HP:0003458)2.77082202
36Gastrointestinal infarctions (HP:0005244)2.75344968
37Granulocytopenia (HP:0001913)2.69589145
38Prolonged bleeding time (HP:0003010)2.63847871
39Abnormality of T cell number (HP:0011839)2.63373963
40Exercise-induced muscle cramps (HP:0003710)2.60966439
41Hemoptysis (HP:0002105)2.59660603
42Keratoconjunctivitis sicca (HP:0001097)2.55998176
43Myoglobinuria (HP:0002913)2.53728629
44Centrally nucleated skeletal muscle fibers (HP:0003687)2.52552078
45Spontaneous hematomas (HP:0007420)2.51266442
46Abnormality of T cells (HP:0002843)2.50677291
47Increased IgE level (HP:0003212)2.48893825
48Keratoconjunctivitis (HP:0001096)2.45409609
49Pulmonary infiltrates (HP:0002113)2.45202959
50Autoimmune hemolytic anemia (HP:0001890)2.44463989
51Muscle hypertrophy of the lower extremities (HP:0008968)2.42978937
52Type 1 muscle fiber predominance (HP:0003803)2.42111739
53T lymphocytopenia (HP:0005403)2.41954655
54Leukocytosis (HP:0001974)2.41878661
55Ventricular tachycardia (HP:0004756)2.37336681
56Eosinophilia (HP:0001880)2.36778676
57Arterial thrombosis (HP:0004420)2.35091723
58Difficulty running (HP:0009046)2.34923125
59Bundle branch block (HP:0011710)2.34287485
60Abnormality of B cell number (HP:0010975)2.33386241
61Abnormality of T cell physiology (HP:0011840)2.32998182
62Autoimmune thrombocytopenia (HP:0001973)2.32797657
63Cellulitis (HP:0100658)2.30258565
64Inflammation of the large intestine (HP:0002037)2.29275015
65Epistaxis (HP:0000421)2.28172231
66Calf muscle hypertrophy (HP:0008981)2.26284032
67Urticaria (HP:0001025)2.26119311
68Neck muscle weakness (HP:0000467)2.22385641
69Ragged-red muscle fibers (HP:0003200)2.18101372
70Abnormality of the pleura (HP:0002103)2.18016380
71Increased IgM level (HP:0003496)2.17234600
72Recurrent viral infections (HP:0004429)2.16924871
73Gastrointestinal inflammation (HP:0004386)2.16433855
74Gingival bleeding (HP:0000225)2.14908215
75Myopathic facies (HP:0002058)2.14480594
76Abnormality of the endocardium (HP:0004306)2.11373695
77Abnormality of eosinophils (HP:0001879)2.11203180
78Pulmonary embolism (HP:0002204)2.11140223
79Vertigo (HP:0002321)2.09322218
80Gingivitis (HP:0000230)2.09275752
81Colitis (HP:0002583)2.08949812
82Abnormality of the prostate (HP:0008775)2.08765416
83Ventricular arrhythmia (HP:0004308)2.08294985
84Stomach cancer (HP:0012126)2.03968748
85Increased cerebral lipofuscin (HP:0011813)2.01195998
86Abnormality of skeletal muscle fiber size (HP:0012084)1.98506111
87Ventricular fibrillation (HP:0001663)1.97640308
88Recurrent bronchitis (HP:0002837)1.97082709
89Severe combined immunodeficiency (HP:0004430)1.96293508
90Syncope (HP:0001279)1.95488807
91EMG: neuropathic changes (HP:0003445)1.95252960
92Frequent falls (HP:0002359)1.94541527
93Facial diplegia (HP:0001349)1.94482306
94Hypochromic anemia (HP:0001931)1.94058314
95Areflexia of lower limbs (HP:0002522)1.91942490
96Petechiae (HP:0000967)1.89790714
97Distal arthrogryposis (HP:0005684)1.89782551
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.89349720
99Acute hepatic failure (HP:0006554)1.89239717
100Amyloidosis (HP:0011034)1.88840143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.27639949
2OBSCN3.23802856
3RIPK43.21824164
4FES2.86041544
5TAOK32.54864686
6TXK2.38964847
7KIT2.38158724
8ERN12.36603682
9BLK2.34854929
10MAP2K32.33684283
11TYK22.22966663
12BCKDK2.02691067
13TNK21.97346652
14SYK1.90705742
15GRK61.72922620
16BTK1.72521899
17JAK31.65024364
18ZAP701.64226666
19TBK11.63474642
20TEC1.61959778
21CSK1.61658619
22TTN1.61013726
23TIE11.59296535
24ITK1.54739411
25PIK3CG1.51205220
26CSF1R1.48154071
27IKBKE1.47867949
28PHKG11.46346669
29PHKG21.46346669
30MAPK121.46241863
31IRAK41.44637474
32MAP3K111.43549620
33HCK1.41555778
34EPHB11.37524274
35MAP3K71.23744679
36LYN1.22927530
37MAP3K131.17284441
38JAK11.16841045
39PINK11.16608564
40LCK1.16104570
41JAK21.15290959
42DAPK21.13614940
43TESK21.10827286
44FRK1.10729077
45MAP3K141.07121195
46CDK191.04846733
47MAP3K30.96668301
48KDR0.96426385
49IKBKB0.89098789
50PRPF4B0.88244225
51MAP3K10.87893309
52GRK70.84959111
53MAP2K60.84849113
54PDK10.84613311
55TGFBR20.83433320
56PRKCQ0.81821352
57MAPK70.80700205
58CDC42BPA0.79445694
59PTK2B0.74419616
60MAP3K50.73793931
61PRKAA20.68898917
62MARK20.68711615
63BMPR20.68166842
64EPHA30.65754791
65TAOK10.64094174
66PRKD10.63205367
67MARK30.60999735
68PIK3CA0.60552738
69MUSK0.58713777
70MATK0.58329640
71FGR0.58076046
72MAPKAPK30.57607031
73GRK50.57496757
74MAPK110.55940804
75TRPM70.53096120
76STK110.52720624
77PDPK10.50910612
78MAP4K20.48800497
79MAPK40.48769845
80OXSR10.48602360
81FYN0.48469003
82SIK20.48013623
83NLK0.47287052
84FGFR30.46520916
85MAP2K40.45360153
86IRAK10.45272953
87TLK10.44777741
88CAMK10.44448945
89HIPK20.43946834
90PIM10.42859841
91CAMK40.42042208
92TAOK20.41287794
93MAP3K60.41035951
94SGK20.39688242
95MAPK130.39463606
96RAF10.39140265
97RPS6KC10.39083478
98RPS6KL10.39083478
99RPS6KA60.38955397
100LRRK20.38378992

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.28138639
2Graft-versus-host disease_Homo sapiens_hsa053323.18017305
3Autoimmune thyroid disease_Homo sapiens_hsa053203.17817955
4Staphylococcus aureus infection_Homo sapiens_hsa051503.11752831
5Primary immunodeficiency_Homo sapiens_hsa053403.09124941
6Leishmaniasis_Homo sapiens_hsa051402.88736669
7Asthma_Homo sapiens_hsa053102.76140615
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.52384927
9Type I diabetes mellitus_Homo sapiens_hsa049402.41989058
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39656378
11Osteoclast differentiation_Homo sapiens_hsa043802.22799169
12Viral myocarditis_Homo sapiens_hsa054162.04318645
13Antigen processing and presentation_Homo sapiens_hsa046121.96422111
14Tuberculosis_Homo sapiens_hsa051521.86675173
15Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.77624209
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75959311
17B cell receptor signaling pathway_Homo sapiens_hsa046621.73118451
18Hematopoietic cell lineage_Homo sapiens_hsa046401.70234791
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35968984
20Other glycan degradation_Homo sapiens_hsa005111.35712407
21Rheumatoid arthritis_Homo sapiens_hsa053231.34876520
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32080311
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28683724
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27235706
25Toxoplasmosis_Homo sapiens_hsa051451.26782474
26Platelet activation_Homo sapiens_hsa046111.20544145
27Malaria_Homo sapiens_hsa051441.19696616
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.16024941
29Measles_Homo sapiens_hsa051621.14619750
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.12335052
31Dilated cardiomyopathy_Homo sapiens_hsa054141.10554752
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09942967
33Influenza A_Homo sapiens_hsa051641.08486959
34T cell receptor signaling pathway_Homo sapiens_hsa046601.07186426
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04273918
36Herpes simplex infection_Homo sapiens_hsa051681.03639348
37Cardiac muscle contraction_Homo sapiens_hsa042601.01258657
38Acute myeloid leukemia_Homo sapiens_hsa052210.95322787
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93776545
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93389249
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.92836559
42Chemokine signaling pathway_Homo sapiens_hsa040620.90965524
43Leukocyte transendothelial migration_Homo sapiens_hsa046700.88340919
44Regulation of autophagy_Homo sapiens_hsa041400.87760909
45Phagosome_Homo sapiens_hsa041450.86641486
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83173149
47Pertussis_Homo sapiens_hsa051330.80824283
48Fatty acid degradation_Homo sapiens_hsa000710.76380136
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.76317404
50African trypanosomiasis_Homo sapiens_hsa051430.74922686
51Glycerophospholipid metabolism_Homo sapiens_hsa005640.74793077
52Legionellosis_Homo sapiens_hsa051340.74463301
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72501921
54TNF signaling pathway_Homo sapiens_hsa046680.68414013
55Linoleic acid metabolism_Homo sapiens_hsa005910.67983441
56Tryptophan metabolism_Homo sapiens_hsa003800.67300006
57Lysosome_Homo sapiens_hsa041420.66714973
58Insulin resistance_Homo sapiens_hsa049310.66446050
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65814161
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65388013
61Oxytocin signaling pathway_Homo sapiens_hsa049210.65248394
62Calcium signaling pathway_Homo sapiens_hsa040200.64875414
63Arachidonic acid metabolism_Homo sapiens_hsa005900.64172808
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63807463
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61798261
66Nitrogen metabolism_Homo sapiens_hsa009100.58229303
67Histidine metabolism_Homo sapiens_hsa003400.57737113
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57605466
69Hepatitis C_Homo sapiens_hsa051600.56861400
70Peroxisome_Homo sapiens_hsa041460.55296346
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54881591
72Renin secretion_Homo sapiens_hsa049240.54030426
73Glycosaminoglycan degradation_Homo sapiens_hsa005310.53868348
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53709435
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51781332
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.50541490
77Gastric acid secretion_Homo sapiens_hsa049710.49305588
78Caffeine metabolism_Homo sapiens_hsa002320.48164198
79ABC transporters_Homo sapiens_hsa020100.47818192
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45410445
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43127835
82PPAR signaling pathway_Homo sapiens_hsa033200.38536772
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38477994
84Apoptosis_Homo sapiens_hsa042100.36087182
85Salivary secretion_Homo sapiens_hsa049700.35742592
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35136610
87VEGF signaling pathway_Homo sapiens_hsa043700.34799184
88Complement and coagulation cascades_Homo sapiens_hsa046100.33226187
89Systemic lupus erythematosus_Homo sapiens_hsa053220.33103118
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33085685
91Hepatitis B_Homo sapiens_hsa051610.30980647
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30039695
93Dorso-ventral axis formation_Homo sapiens_hsa043200.29887162
94Glycerolipid metabolism_Homo sapiens_hsa005610.29745532
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29323756
96GnRH signaling pathway_Homo sapiens_hsa049120.28564804
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.27734381
98Olfactory transduction_Homo sapiens_hsa047400.25743680
99Inositol phosphate metabolism_Homo sapiens_hsa005620.24446256
100Non-small cell lung cancer_Homo sapiens_hsa052230.24170103

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