

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.61219578 |
| 2 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 5.55618235 |
| 3 | viral transcription (GO:0019083) | 5.18767890 |
| 4 | translational termination (GO:0006415) | 5.13615436 |
| 5 | ribosomal large subunit biogenesis (GO:0042273) | 4.99908213 |
| 6 | establishment of integrated proviral latency (GO:0075713) | 4.84692487 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 4.81130854 |
| 8 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.78482176 |
| 9 | proteasome assembly (GO:0043248) | 4.78065288 |
| 10 | ATP synthesis coupled proton transport (GO:0015986) | 4.75046179 |
| 11 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.75046179 |
| 12 | CENP-A containing nucleosome assembly (GO:0034080) | 4.74368662 |
| 13 | chromatin remodeling at centromere (GO:0031055) | 4.73071310 |
| 14 | cotranslational protein targeting to membrane (GO:0006613) | 4.72625612 |
| 15 | protein targeting to ER (GO:0045047) | 4.66641484 |
| 16 | maturation of SSU-rRNA (GO:0030490) | 4.63399604 |
| 17 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.58733856 |
| 18 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 4.49458165 |
| 19 | chaperone-mediated protein transport (GO:0072321) | 4.40050723 |
| 20 | protein localization to endoplasmic reticulum (GO:0070972) | 4.38085604 |
| 21 | translational elongation (GO:0006414) | 4.34988639 |
| 22 | translational initiation (GO:0006413) | 4.30387898 |
| 23 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 4.10050267 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.08768311 |
| 25 | viral life cycle (GO:0019058) | 3.97549864 |
| 26 | cellular protein complex disassembly (GO:0043624) | 3.96417848 |
| 27 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.94651862 |
| 28 | protein neddylation (GO:0045116) | 3.92565327 |
| 29 | translation (GO:0006412) | 3.91075580 |
| 30 | histone exchange (GO:0043486) | 3.89290208 |
| 31 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.88566306 |
| 32 | formation of translation preinitiation complex (GO:0001731) | 3.84375386 |
| 33 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.82563633 |
| 34 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.82045159 |
| 35 | DNA replication checkpoint (GO:0000076) | 3.77829939 |
| 36 | DNA strand elongation (GO:0022616) | 3.76863628 |
| 37 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.74613734 |
| 38 | negative regulation of ligase activity (GO:0051352) | 3.74494655 |
| 39 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.74494655 |
| 40 | establishment of viral latency (GO:0019043) | 3.73556523 |
| 41 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.68281328 |
| 42 | DNA replication-independent nucleosome organization (GO:0034724) | 3.68281328 |
| 43 | respiratory electron transport chain (GO:0022904) | 3.68207923 |
| 44 | mitotic metaphase plate congression (GO:0007080) | 3.68038578 |
| 45 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.67448530 |
| 46 | regulation of mitochondrial translation (GO:0070129) | 3.66831407 |
| 47 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.66167947 |
| 48 | termination of RNA polymerase III transcription (GO:0006386) | 3.61441222 |
| 49 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.61441222 |
| 50 | electron transport chain (GO:0022900) | 3.58070567 |
| 51 | purine nucleobase biosynthetic process (GO:0009113) | 3.57640087 |
| 52 | protein complex disassembly (GO:0043241) | 3.43165455 |
| 53 | protein localization to kinetochore (GO:0034501) | 3.38411504 |
| 54 | rRNA processing (GO:0006364) | 3.37315762 |
| 55 | spliceosomal snRNP assembly (GO:0000387) | 3.37158045 |
| 56 | ribosome assembly (GO:0042255) | 3.34333213 |
| 57 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.32758930 |
| 58 | macromolecular complex disassembly (GO:0032984) | 3.32664552 |
| 59 | cellular component biogenesis (GO:0044085) | 3.31828455 |
| 60 | IMP biosynthetic process (GO:0006188) | 3.31539473 |
| 61 | DNA damage response, detection of DNA damage (GO:0042769) | 3.31140099 |
| 62 | telomere maintenance via recombination (GO:0000722) | 3.30589285 |
| 63 | nucleobase biosynthetic process (GO:0046112) | 3.29542673 |
| 64 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.29154380 |
| 65 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 3.27352254 |
| 66 | rRNA modification (GO:0000154) | 3.24211911 |
| 67 | rRNA metabolic process (GO:0016072) | 3.22614255 |
| 68 | mitotic recombination (GO:0006312) | 3.22191935 |
| 69 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.20404811 |
| 70 | protein targeting to mitochondrion (GO:0006626) | 3.19722374 |
| 71 | protein targeting to membrane (GO:0006612) | 3.17381367 |
| 72 | cullin deneddylation (GO:0010388) | 3.16800848 |
| 73 | metaphase plate congression (GO:0051310) | 3.15616504 |
| 74 | oxidative phosphorylation (GO:0006119) | 3.15565963 |
| 75 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.14037513 |
| 76 | kinetochore organization (GO:0051383) | 3.13226614 |
| 77 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.12674961 |
| 78 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.12050810 |
| 79 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.12050810 |
| 80 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.12050810 |
| 81 | regulation of helicase activity (GO:0051095) | 3.11304574 |
| 82 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.10883552 |
| 83 | mRNA catabolic process (GO:0006402) | 3.10248136 |
| 84 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.09714671 |
| 85 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.09714671 |
| 86 | protein complex biogenesis (GO:0070271) | 3.08501618 |
| 87 | positive regulation of ligase activity (GO:0051351) | 3.06652770 |
| 88 | DNA ligation (GO:0006266) | 3.06482436 |
| 89 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.03741687 |
| 90 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.03741687 |
| 91 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.01983384 |
| 92 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.01983384 |
| 93 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.00925127 |
| 94 | negative regulation of sister chromatid segregation (GO:0033046) | 3.00925127 |
| 95 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.00925127 |
| 96 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.00925127 |
| 97 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.00925127 |
| 98 | protein localization to chromosome, centromeric region (GO:0071459) | 3.00439950 |
| 99 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.00120886 |
| 100 | protein localization to mitochondrion (GO:0070585) | 2.99934611 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.19727933 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.88375808 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.53750129 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.27039443 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.02733380 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.85066283 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.47412393 |
| 8 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.26689702 |
| 9 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.18543654 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.12007448 |
| 11 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.07664313 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.05019993 |
| 13 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.01564281 |
| 14 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.99437075 |
| 15 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.97370538 |
| 16 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.83852149 |
| 17 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.80340027 |
| 18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.77903505 |
| 19 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.73819599 |
| 20 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.57832822 |
| 21 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.53147185 |
| 22 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.39541819 |
| 23 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.30307733 |
| 24 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.30003964 |
| 25 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.25090253 |
| 26 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.22863849 |
| 27 | TTF2_22483619_ChIP-Seq_HELA_Human | 2.22688559 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.19930910 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.16298110 |
| 30 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.05863583 |
| 31 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.05816347 |
| 32 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.04769271 |
| 33 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.02730508 |
| 34 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.96492141 |
| 35 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.87074896 |
| 36 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.84137890 |
| 37 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.81767790 |
| 38 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.81326114 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.77627773 |
| 40 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.77202797 |
| 41 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.76967606 |
| 42 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.75656098 |
| 43 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.74212935 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.72075210 |
| 45 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.71680408 |
| 46 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.71475037 |
| 47 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.70082814 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.66604920 |
| 49 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.58487912 |
| 50 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.57884956 |
| 51 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.52090577 |
| 52 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.49528874 |
| 53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.47569973 |
| 54 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.38521749 |
| 55 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.34369693 |
| 56 | EWS_26573619_Chip-Seq_HEK293_Human | 1.31535242 |
| 57 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.30939385 |
| 58 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.29860551 |
| 59 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.25659465 |
| 60 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.20719432 |
| 61 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.20670663 |
| 62 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.18878331 |
| 63 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.15706147 |
| 64 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.14252807 |
| 65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.14132577 |
| 66 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11815458 |
| 67 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.07946847 |
| 68 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.05272980 |
| 69 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.02514643 |
| 70 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.02024991 |
| 71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.99619937 |
| 72 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 0.99563284 |
| 73 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 0.99563284 |
| 74 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 0.99563284 |
| 75 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.99092086 |
| 76 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.98598401 |
| 77 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.96833063 |
| 78 | VDR_22108803_ChIP-Seq_LS180_Human | 0.96379705 |
| 79 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.94827104 |
| 80 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94739866 |
| 81 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.94541272 |
| 82 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.94329504 |
| 83 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.93913552 |
| 84 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.92697676 |
| 85 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.88987471 |
| 86 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.88508113 |
| 87 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.85864194 |
| 88 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.82782894 |
| 89 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.81839807 |
| 90 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.81742050 |
| 91 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.81437875 |
| 92 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.80588383 |
| 93 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.80351962 |
| 94 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.79525532 |
| 95 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.74551092 |
| 96 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.70398590 |
| 97 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.68920571 |
| 98 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.68614387 |
| 99 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.68532884 |
| 100 | * ELF5_23300383_ChIP-Seq_T47D_Human | 0.68368178 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.34698514 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.22199580 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.11599088 |
| 4 | MP0008058_abnormal_DNA_repair | 4.07947652 |
| 5 | MP0009379_abnormal_foot_pigmentation | 3.74994113 |
| 6 | MP0003111_abnormal_nucleus_morphology | 3.33452671 |
| 7 | MP0003077_abnormal_cell_cycle | 3.23384392 |
| 8 | MP0006292_abnormal_olfactory_placode | 3.01323698 |
| 9 | MP0003718_maternal_effect | 3.00450702 |
| 10 | MP0008932_abnormal_embryonic_tissue | 2.87962989 |
| 11 | MP0003941_abnormal_skin_development | 2.87261514 |
| 12 | MP0008877_abnormal_DNA_methylation | 2.57167642 |
| 13 | MP0008057_abnormal_DNA_replication | 2.57130451 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.49275120 |
| 15 | MP0010030_abnormal_orbit_morphology | 2.38228182 |
| 16 | MP0003806_abnormal_nucleotide_metabolis | 2.33221825 |
| 17 | MP0003186_abnormal_redox_activity | 2.23996190 |
| 18 | MP0001293_anophthalmia | 2.10129335 |
| 19 | MP0009697_abnormal_copulation | 1.91897476 |
| 20 | MP0003786_premature_aging | 1.87737217 |
| 21 | MP0002938_white_spotting | 1.85685690 |
| 22 | MP0006035_abnormal_mitochondrial_morpho | 1.70373895 |
| 23 | MP0006036_abnormal_mitochondrial_physio | 1.64982425 |
| 24 | MP0001730_embryonic_growth_arrest | 1.64820962 |
| 25 | MP0000350_abnormal_cell_proliferation | 1.63149736 |
| 26 | MP0003567_abnormal_fetal_cardiomyocyte | 1.62503160 |
| 27 | MP0003890_abnormal_embryonic-extraembry | 1.61456417 |
| 28 | MP0008789_abnormal_olfactory_epithelium | 1.52624590 |
| 29 | MP0002210_abnormal_sex_determination | 1.52001784 |
| 30 | MP0003315_abnormal_perineum_morphology | 1.46904819 |
| 31 | MP0001697_abnormal_embryo_size | 1.44469652 |
| 32 | MP0003937_abnormal_limbs/digits/tail_de | 1.43445216 |
| 33 | MP0005380_embryogenesis_phenotype | 1.38425548 |
| 34 | MP0001672_abnormal_embryogenesis/_devel | 1.38425548 |
| 35 | MP0006072_abnormal_retinal_apoptosis | 1.35981569 |
| 36 | MP0002085_abnormal_embryonic_tissue | 1.34259352 |
| 37 | MP0002084_abnormal_developmental_patter | 1.34206000 |
| 38 | MP0001529_abnormal_vocalization | 1.34129537 |
| 39 | MP0001286_abnormal_eye_development | 1.25310204 |
| 40 | MP0001929_abnormal_gametogenesis | 1.24980558 |
| 41 | MP0003136_yellow_coat_color | 1.24543364 |
| 42 | MP0000372_irregular_coat_pigmentation | 1.23752702 |
| 43 | MP0001145_abnormal_male_reproductive | 1.22066914 |
| 44 | MP0000358_abnormal_cell_content/ | 1.20746569 |
| 45 | MP0002160_abnormal_reproductive_system | 1.19279531 |
| 46 | MP0002233_abnormal_nose_morphology | 1.19003996 |
| 47 | MP0009672_abnormal_birth_weight | 1.18567948 |
| 48 | MP0005084_abnormal_gallbladder_morpholo | 1.16839882 |
| 49 | MP0002080_prenatal_lethality | 1.16785469 |
| 50 | MP0000653_abnormal_sex_gland | 1.15670681 |
| 51 | MP0003984_embryonic_growth_retardation | 1.15415503 |
| 52 | MP0002088_abnormal_embryonic_growth/wei | 1.12420012 |
| 53 | MP0000313_abnormal_cell_death | 1.10545887 |
| 54 | MP0002697_abnormal_eye_size | 1.10129589 |
| 55 | MP0003123_paternal_imprinting | 1.07991705 |
| 56 | MP0002234_abnormal_pharynx_morphology | 1.07116171 |
| 57 | MP0003119_abnormal_digestive_system | 1.06859347 |
| 58 | MP0002102_abnormal_ear_morphology | 1.04485122 |
| 59 | MP0000049_abnormal_middle_ear | 1.02882759 |
| 60 | MP0002837_dystrophic_cardiac_calcinosis | 0.99377196 |
| 61 | MP0005499_abnormal_olfactory_system | 0.98080864 |
| 62 | MP0005394_taste/olfaction_phenotype | 0.98080864 |
| 63 | MP0004215_abnormal_myocardial_fiber | 0.95092938 |
| 64 | MP0010307_abnormal_tumor_latency | 0.93027122 |
| 65 | MP0003121_genomic_imprinting | 0.91518175 |
| 66 | MP0002163_abnormal_gland_morphology | 0.89147821 |
| 67 | MP0001188_hyperpigmentation | 0.88917921 |
| 68 | MP0005395_other_phenotype | 0.86624721 |
| 69 | MP0008995_early_reproductive_senescence | 0.85267132 |
| 70 | MP0003950_abnormal_plasma_membrane | 0.85181152 |
| 71 | MP0002111_abnormal_tail_morphology | 0.81890148 |
| 72 | MP0001119_abnormal_female_reproductive | 0.80969463 |
| 73 | MP0005408_hypopigmentation | 0.80544605 |
| 74 | MP0000490_abnormal_crypts_of | 0.80439209 |
| 75 | MP0002796_impaired_skin_barrier | 0.78595604 |
| 76 | MP0009250_abnormal_appendicular_skeleto | 0.75868096 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 0.74589937 |
| 78 | MP0000537_abnormal_urethra_morphology | 0.74289895 |
| 79 | MP0005501_abnormal_skin_physiology | 0.74254168 |
| 80 | MP0004147_increased_porphyrin_level | 0.74043979 |
| 81 | MP0002751_abnormal_autonomic_nervous | 0.73936239 |
| 82 | MP0004197_abnormal_fetal_growth/weight/ | 0.72559506 |
| 83 | MP0005389_reproductive_system_phenotype | 0.72221536 |
| 84 | MP0000762_abnormal_tongue_morphology | 0.71042401 |
| 85 | MP0003698_abnormal_male_reproductive | 0.70151525 |
| 86 | MP0005075_abnormal_melanosome_morpholog | 0.69515754 |
| 87 | MP0003755_abnormal_palate_morphology | 0.68825786 |
| 88 | MP0009703_decreased_birth_body | 0.67980690 |
| 89 | MP0001881_abnormal_mammary_gland | 0.64737555 |
| 90 | MP0002086_abnormal_extraembryonic_tissu | 0.64662749 |
| 91 | MP0002019_abnormal_tumor_incidence | 0.64521533 |
| 92 | MP0010352_gastrointestinal_tract_polyps | 0.64095187 |
| 93 | MP0002161_abnormal_fertility/fecundity | 0.63219601 |
| 94 | MP0001764_abnormal_homeostasis | 0.62741106 |
| 95 | MP0000647_abnormal_sebaceous_gland | 0.62020781 |
| 96 | MP0003936_abnormal_reproductive_system | 0.60361933 |
| 97 | MP0005391_vision/eye_phenotype | 0.58885947 |
| 98 | MP0003699_abnormal_female_reproductive | 0.58299298 |
| 99 | MP0002277_abnormal_respiratory_mucosa | 0.56241021 |
| 100 | MP0002092_abnormal_eye_morphology | 0.55172222 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 4.83197849 |
| 2 | Reticulocytopenia (HP:0001896) | 4.67212741 |
| 3 | Acute encephalopathy (HP:0006846) | 4.39097116 |
| 4 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.36612129 |
| 5 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.23078561 |
| 6 | Macrocytic anemia (HP:0001972) | 4.20000207 |
| 7 | Mitochondrial inheritance (HP:0001427) | 4.00966792 |
| 8 | Increased hepatocellular lipid droplets (HP:0006565) | 3.99568510 |
| 9 | Progressive macrocephaly (HP:0004481) | 3.91061071 |
| 10 | Abnormal number of erythroid precursors (HP:0012131) | 3.87824729 |
| 11 | Increased CSF lactate (HP:0002490) | 3.79762922 |
| 12 | Lipid accumulation in hepatocytes (HP:0006561) | 3.52833059 |
| 13 | Colon cancer (HP:0003003) | 3.49370904 |
| 14 | Hepatocellular necrosis (HP:0001404) | 3.44114331 |
| 15 | Cerebral edema (HP:0002181) | 3.35492379 |
| 16 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.28657631 |
| 17 | Hepatic necrosis (HP:0002605) | 3.22555083 |
| 18 | Chromsome breakage (HP:0040012) | 3.19910884 |
| 19 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.09772229 |
| 20 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.09772229 |
| 21 | Abnormality of the labia minora (HP:0012880) | 3.03309534 |
| 22 | Renal Fanconi syndrome (HP:0001994) | 2.94344420 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 2.90107535 |
| 24 | Aplastic anemia (HP:0001915) | 2.87447984 |
| 25 | Microvesicular hepatic steatosis (HP:0001414) | 2.84643201 |
| 26 | Pallor (HP:0000980) | 2.83202948 |
| 27 | Meckel diverticulum (HP:0002245) | 2.82009085 |
| 28 | Increased serum lactate (HP:0002151) | 2.74009032 |
| 29 | Stenosis of the external auditory canal (HP:0000402) | 2.73802421 |
| 30 | Type I transferrin isoform profile (HP:0003642) | 2.69427399 |
| 31 | Abnormality of the ileum (HP:0001549) | 2.66618745 |
| 32 | Lactic acidosis (HP:0003128) | 2.61596479 |
| 33 | Multiple enchondromatosis (HP:0005701) | 2.55605500 |
| 34 | Abnormal lung lobation (HP:0002101) | 2.53259440 |
| 35 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.52651555 |
| 36 | Reduced antithrombin III activity (HP:0001976) | 2.51485076 |
| 37 | Increased intramyocellular lipid droplets (HP:0012240) | 2.50256033 |
| 38 | Abnormality of chromosome stability (HP:0003220) | 2.48666467 |
| 39 | Abnormality of the preputium (HP:0100587) | 2.47433153 |
| 40 | Abnormality of methionine metabolism (HP:0010901) | 2.45571520 |
| 41 | Septo-optic dysplasia (HP:0100842) | 2.45052912 |
| 42 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.42814365 |
| 43 | Increased serum pyruvate (HP:0003542) | 2.41974148 |
| 44 | Triphalangeal thumb (HP:0001199) | 2.41861447 |
| 45 | Exercise intolerance (HP:0003546) | 2.40934096 |
| 46 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.37735767 |
| 47 | Abnormality of alanine metabolism (HP:0010916) | 2.37702231 |
| 48 | Hyperalaninemia (HP:0003348) | 2.37702231 |
| 49 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.37702231 |
| 50 | Respiratory failure (HP:0002878) | 2.36167878 |
| 51 | Leukodystrophy (HP:0002415) | 2.35913600 |
| 52 | Methylmalonic acidemia (HP:0002912) | 2.34568456 |
| 53 | Respiratory difficulties (HP:0002880) | 2.34532013 |
| 54 | Abnormality of serum amino acid levels (HP:0003112) | 2.34058534 |
| 55 | Hyperglycinemia (HP:0002154) | 2.29304361 |
| 56 | Birth length less than 3rd percentile (HP:0003561) | 2.27253807 |
| 57 | Exertional dyspnea (HP:0002875) | 2.22739419 |
| 58 | Duodenal stenosis (HP:0100867) | 2.19969485 |
| 59 | Small intestinal stenosis (HP:0012848) | 2.19969485 |
| 60 | Abnormal protein glycosylation (HP:0012346) | 2.16461421 |
| 61 | Abnormal glycosylation (HP:0012345) | 2.16461421 |
| 62 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.16461421 |
| 63 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.16461421 |
| 64 | Facial cleft (HP:0002006) | 2.15527450 |
| 65 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.14644986 |
| 66 | Absent septum pellucidum (HP:0001331) | 2.14528709 |
| 67 | Pancytopenia (HP:0001876) | 2.12620723 |
| 68 | Megaloblastic anemia (HP:0001889) | 2.11941919 |
| 69 | Oral leukoplakia (HP:0002745) | 2.06993054 |
| 70 | Abnormality of glycolysis (HP:0004366) | 2.05343965 |
| 71 | Optic disc pallor (HP:0000543) | 2.02430119 |
| 72 | Horseshoe kidney (HP:0000085) | 2.01419317 |
| 73 | Methylmalonic aciduria (HP:0012120) | 2.01141828 |
| 74 | Congenital, generalized hypertrichosis (HP:0004540) | 2.00615491 |
| 75 | Abnormality of the septum pellucidum (HP:0007375) | 2.00510682 |
| 76 | Lethargy (HP:0001254) | 2.00154502 |
| 77 | Abnormality of the duodenum (HP:0002246) | 1.98002886 |
| 78 | Absent thumb (HP:0009777) | 1.97715642 |
| 79 | Cleft eyelid (HP:0000625) | 1.94578321 |
| 80 | Degeneration of anterior horn cells (HP:0002398) | 1.92273389 |
| 81 | Abnormality of the anterior horn cell (HP:0006802) | 1.92273389 |
| 82 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.91066959 |
| 83 | Increased muscle lipid content (HP:0009058) | 1.90361803 |
| 84 | Neoplasm of the colon (HP:0100273) | 1.89937182 |
| 85 | Amniotic constriction ring (HP:0009775) | 1.89472251 |
| 86 | Abnormality of placental membranes (HP:0011409) | 1.89472251 |
| 87 | Myelodysplasia (HP:0002863) | 1.88492403 |
| 88 | Sensory axonal neuropathy (HP:0003390) | 1.87336954 |
| 89 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 1.86915861 |
| 90 | Supernumerary spleens (HP:0009799) | 1.83529230 |
| 91 | Embryonal renal neoplasm (HP:0011794) | 1.81722722 |
| 92 | Abnormality of renal resorption (HP:0011038) | 1.81535931 |
| 93 | Sparse eyelashes (HP:0000653) | 1.79200413 |
| 94 | Cerebral hypomyelination (HP:0006808) | 1.78421931 |
| 95 | Carpal bone hypoplasia (HP:0001498) | 1.73654435 |
| 96 | Hyperglycinuria (HP:0003108) | 1.73459387 |
| 97 | Premature ovarian failure (HP:0008209) | 1.72423254 |
| 98 | Absent radius (HP:0003974) | 1.71094686 |
| 99 | Rhabdomyosarcoma (HP:0002859) | 1.66288787 |
| 100 | Abnormality of glycine metabolism (HP:0010895) | 1.65419844 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.39398160 |
| 2 | VRK2 | 4.26314294 |
| 3 | CDC7 | 3.77443813 |
| 4 | PBK | 3.11437977 |
| 5 | SRPK1 | 2.96385563 |
| 6 | TTK | 2.76201126 |
| 7 | NEK1 | 2.71828938 |
| 8 | STK16 | 2.63400512 |
| 9 | EIF2AK3 | 2.54571469 |
| 10 | ZAK | 2.41581407 |
| 11 | VRK1 | 2.27339780 |
| 12 | TSSK6 | 2.22933148 |
| 13 | NME2 | 2.22278203 |
| 14 | PLK3 | 2.22171444 |
| 15 | MST4 | 2.19839618 |
| 16 | EIF2AK1 | 2.19587779 |
| 17 | PLK4 | 2.07222842 |
| 18 | TAF1 | 1.99250385 |
| 19 | MKNK1 | 1.79509319 |
| 20 | CDK19 | 1.75416087 |
| 21 | NUAK1 | 1.72520608 |
| 22 | WEE1 | 1.72106958 |
| 23 | PASK | 1.68187920 |
| 24 | PLK1 | 1.65619018 |
| 25 | TRIM28 | 1.63524492 |
| 26 | MAP3K12 | 1.63268980 |
| 27 | NME1 | 1.57709208 |
| 28 | BRSK2 | 1.49153382 |
| 29 | MKNK2 | 1.44708204 |
| 30 | CHEK2 | 1.26235566 |
| 31 | AURKB | 1.25194485 |
| 32 | BMPR1B | 1.15203430 |
| 33 | STK38L | 1.13080196 |
| 34 | PNCK | 1.04340180 |
| 35 | ATR | 1.01185717 |
| 36 | SCYL2 | 1.00812465 |
| 37 | DYRK2 | 1.00176360 |
| 38 | WNK3 | 0.98009003 |
| 39 | TLK1 | 0.97000865 |
| 40 | PDK2 | 0.95673097 |
| 41 | NEK2 | 0.92833674 |
| 42 | BRSK1 | 0.91522321 |
| 43 | STK24 | 0.89912725 |
| 44 | EIF2AK2 | 0.89771846 |
| 45 | STK3 | 0.89321727 |
| 46 | CDK8 | 0.87013963 |
| 47 | PAK4 | 0.86063880 |
| 48 | AURKA | 0.84481885 |
| 49 | STK4 | 0.84467248 |
| 50 | ACVR1B | 0.84160011 |
| 51 | RPS6KB2 | 0.79644022 |
| 52 | MYLK | 0.78678362 |
| 53 | TNIK | 0.78635661 |
| 54 | DYRK3 | 0.76708004 |
| 55 | TGFBR1 | 0.75845347 |
| 56 | CHEK1 | 0.74775299 |
| 57 | CSNK2A2 | 0.73973710 |
| 58 | BRAF | 0.72662758 |
| 59 | CDK7 | 0.71675894 |
| 60 | LIMK1 | 0.70841939 |
| 61 | ATM | 0.70248500 |
| 62 | CSNK2A1 | 0.69016495 |
| 63 | BCKDK | 0.67579702 |
| 64 | CSNK1G1 | 0.67096841 |
| 65 | ERBB4 | 0.65951017 |
| 66 | ILK | 0.64678060 |
| 67 | FLT3 | 0.63394087 |
| 68 | CCNB1 | 0.61476065 |
| 69 | DAPK1 | 0.59264841 |
| 70 | MAP4K2 | 0.56152338 |
| 71 | KDR | 0.55601155 |
| 72 | PLK2 | 0.54769441 |
| 73 | INSRR | 0.52277687 |
| 74 | CSNK1G3 | 0.52252209 |
| 75 | MAP3K10 | 0.52105525 |
| 76 | DMPK | 0.50199702 |
| 77 | ARAF | 0.49601869 |
| 78 | DAPK3 | 0.49030460 |
| 79 | CSNK1E | 0.46127433 |
| 80 | RPS6KA4 | 0.45010136 |
| 81 | CSNK1G2 | 0.44850189 |
| 82 | ALK | 0.41399497 |
| 83 | TIE1 | 0.40993879 |
| 84 | CLK1 | 0.40373845 |
| 85 | TESK2 | 0.40175976 |
| 86 | PRKCI | 0.40103107 |
| 87 | CDK1 | 0.39139108 |
| 88 | MAP3K8 | 0.37824167 |
| 89 | RPS6KA5 | 0.36851600 |
| 90 | CDK2 | 0.36550415 |
| 91 | GRK1 | 0.33644645 |
| 92 | LRRK2 | 0.32793856 |
| 93 | ABL2 | 0.32350681 |
| 94 | MAP3K4 | 0.32312268 |
| 95 | OXSR1 | 0.31378304 |
| 96 | PAK1 | 0.31368110 |
| 97 | FGFR1 | 0.30917748 |
| 98 | CDK3 | 0.28022872 |
| 99 | PRKDC | 0.27771210 |
| 100 | CDK9 | 0.27103506 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.79610614 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.24041640 |
| 3 | Mismatch repair_Homo sapiens_hsa03430 | 3.73969967 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.69145645 |
| 5 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.29415191 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.98281647 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.92041603 |
| 8 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.87368096 |
| 9 | Protein export_Homo sapiens_hsa03060 | 2.73736399 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.63274676 |
| 11 | Spliceosome_Homo sapiens_hsa03040 | 2.36275752 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.33611806 |
| 13 | Non-homologous end-joining_Homo sapiens_hsa03450 | 2.30924039 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.27016067 |
| 15 | Huntingtons disease_Homo sapiens_hsa05016 | 2.26707586 |
| 16 | RNA transport_Homo sapiens_hsa03013 | 2.16165331 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.93888607 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.89580599 |
| 19 | Alzheimers disease_Homo sapiens_hsa05010 | 1.86738610 |
| 20 | RNA degradation_Homo sapiens_hsa03018 | 1.82531508 |
| 21 | Cell cycle_Homo sapiens_hsa04110 | 1.80244687 |
| 22 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.79393113 |
| 23 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.76845302 |
| 24 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.74888390 |
| 25 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.53321005 |
| 26 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.53211975 |
| 27 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.45169690 |
| 28 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.39057686 |
| 29 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.35683110 |
| 30 | Purine metabolism_Homo sapiens_hsa00230 | 1.33209166 |
| 31 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.30769469 |
| 32 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.29345296 |
| 33 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.27349478 |
| 34 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.17251637 |
| 35 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.17243695 |
| 36 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.16711960 |
| 37 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.09232019 |
| 38 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.03296439 |
| 39 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.02831322 |
| 40 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.00533821 |
| 41 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.94915234 |
| 42 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.94594490 |
| 43 | Carbon metabolism_Homo sapiens_hsa01200 | 0.88548310 |
| 44 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.82656126 |
| 45 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.82110311 |
| 46 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.79159455 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.77159170 |
| 48 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.74139145 |
| 49 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.73109474 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.70508005 |
| 51 | Metabolic pathways_Homo sapiens_hsa01100 | 0.69020338 |
| 52 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.64013227 |
| 53 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.63393635 |
| 54 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.57144772 |
| 55 | Sulfur relay system_Homo sapiens_hsa04122 | 0.53441411 |
| 56 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.50938007 |
| 57 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.50720059 |
| 58 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.50689946 |
| 59 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.46838312 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44684130 |
| 61 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.43425855 |
| 62 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.41963448 |
| 63 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.39851190 |
| 64 | Peroxisome_Homo sapiens_hsa04146 | 0.39000845 |
| 65 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.37812332 |
| 66 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.34462507 |
| 67 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.33959830 |
| 68 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.33788072 |
| 69 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.30744503 |
| 70 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.30710281 |
| 71 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.30049960 |
| 72 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.30011176 |
| 73 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.28350946 |
| 74 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.28210893 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.28005325 |
| 76 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.27349452 |
| 77 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.26822755 |
| 78 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.25095010 |
| 79 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.25067426 |
| 80 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.24801116 |
| 81 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.23278209 |
| 82 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.23084285 |
| 83 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.22372154 |
| 84 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.20777189 |
| 85 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.20769455 |
| 86 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.19525684 |
| 87 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.19078732 |
| 88 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.18425331 |
| 89 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.17908848 |
| 90 | Retinol metabolism_Homo sapiens_hsa00830 | 0.17632911 |
| 91 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.17067368 |
| 92 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.16147073 |
| 93 | Alcoholism_Homo sapiens_hsa05034 | 0.16116608 |
| 94 | Phototransduction_Homo sapiens_hsa04744 | 0.14362701 |
| 95 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.11302646 |
| 96 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.11098710 |
| 97 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.11066331 |
| 98 | Galactose metabolism_Homo sapiens_hsa00052 | 0.08907432 |
| 99 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.08328903 |
| 100 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.06723162 |

