C14ORF166

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.61219578
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.55618235
3viral transcription (GO:0019083)5.18767890
4translational termination (GO:0006415)5.13615436
5ribosomal large subunit biogenesis (GO:0042273)4.99908213
6establishment of integrated proviral latency (GO:0075713)4.84692487
7ribosomal small subunit biogenesis (GO:0042274)4.81130854
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.78482176
9proteasome assembly (GO:0043248)4.78065288
10ATP synthesis coupled proton transport (GO:0015986)4.75046179
11energy coupled proton transport, down electrochemical gradient (GO:0015985)4.75046179
12CENP-A containing nucleosome assembly (GO:0034080)4.74368662
13chromatin remodeling at centromere (GO:0031055)4.73071310
14cotranslational protein targeting to membrane (GO:0006613)4.72625612
15protein targeting to ER (GO:0045047)4.66641484
16maturation of SSU-rRNA (GO:0030490)4.63399604
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.58733856
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.49458165
19chaperone-mediated protein transport (GO:0072321)4.40050723
20protein localization to endoplasmic reticulum (GO:0070972)4.38085604
21translational elongation (GO:0006414)4.34988639
22translational initiation (GO:0006413)4.30387898
23nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.10050267
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.08768311
25viral life cycle (GO:0019058)3.97549864
26cellular protein complex disassembly (GO:0043624)3.96417848
27DNA strand elongation involved in DNA replication (GO:0006271)3.94651862
28protein neddylation (GO:0045116)3.92565327
29translation (GO:0006412)3.91075580
30histone exchange (GO:0043486)3.89290208
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.88566306
32formation of translation preinitiation complex (GO:0001731)3.84375386
33telomere maintenance via semi-conservative replication (GO:0032201)3.82563633
34anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.82045159
35DNA replication checkpoint (GO:0000076)3.77829939
36DNA strand elongation (GO:0022616)3.76863628
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.74613734
38negative regulation of ligase activity (GO:0051352)3.74494655
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.74494655
40establishment of viral latency (GO:0019043)3.73556523
41DNA replication-independent nucleosome assembly (GO:0006336)3.68281328
42DNA replication-independent nucleosome organization (GO:0034724)3.68281328
43respiratory electron transport chain (GO:0022904)3.68207923
44mitotic metaphase plate congression (GO:0007080)3.68038578
45mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67448530
46regulation of mitochondrial translation (GO:0070129)3.66831407
47ribonucleoprotein complex biogenesis (GO:0022613)3.66167947
48termination of RNA polymerase III transcription (GO:0006386)3.61441222
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.61441222
50electron transport chain (GO:0022900)3.58070567
51purine nucleobase biosynthetic process (GO:0009113)3.57640087
52protein complex disassembly (GO:0043241)3.43165455
53protein localization to kinetochore (GO:0034501)3.38411504
54rRNA processing (GO:0006364)3.37315762
55spliceosomal snRNP assembly (GO:0000387)3.37158045
56ribosome assembly (GO:0042255)3.34333213
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.32758930
58macromolecular complex disassembly (GO:0032984)3.32664552
59cellular component biogenesis (GO:0044085)3.31828455
60IMP biosynthetic process (GO:0006188)3.31539473
61DNA damage response, detection of DNA damage (GO:0042769)3.31140099
62telomere maintenance via recombination (GO:0000722)3.30589285
63nucleobase biosynthetic process (GO:0046112)3.29542673
64nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29154380
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.27352254
66rRNA modification (GO:0000154)3.24211911
67rRNA metabolic process (GO:0016072)3.22614255
68mitotic recombination (GO:0006312)3.22191935
69positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20404811
70protein targeting to mitochondrion (GO:0006626)3.19722374
71protein targeting to membrane (GO:0006612)3.17381367
72cullin deneddylation (GO:0010388)3.16800848
73metaphase plate congression (GO:0051310)3.15616504
74oxidative phosphorylation (GO:0006119)3.15565963
75regulation of cellular amino acid metabolic process (GO:0006521)3.14037513
76kinetochore organization (GO:0051383)3.13226614
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12674961
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12050810
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12050810
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12050810
81regulation of helicase activity (GO:0051095)3.11304574
82mitochondrial respiratory chain complex assembly (GO:0033108)3.10883552
83mRNA catabolic process (GO:0006402)3.10248136
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09714671
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09714671
86protein complex biogenesis (GO:0070271)3.08501618
87positive regulation of ligase activity (GO:0051351)3.06652770
88DNA ligation (GO:0006266)3.06482436
89signal transduction involved in DNA integrity checkpoint (GO:0072401)3.03741687
90signal transduction involved in DNA damage checkpoint (GO:0072422)3.03741687
91regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01983384
92regulation of mitotic spindle checkpoint (GO:1903504)3.01983384
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.00925127
94negative regulation of sister chromatid segregation (GO:0033046)3.00925127
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00925127
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00925127
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00925127
98protein localization to chromosome, centromeric region (GO:0071459)3.00439950
99regulation of ubiquitin-protein transferase activity (GO:0051438)3.00120886
100protein localization to mitochondrion (GO:0070585)2.99934611

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.19727933
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.88375808
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.53750129
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.27039443
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.02733380
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85066283
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.47412393
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26689702
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.18543654
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.12007448
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.07664313
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.05019993
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.01564281
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.99437075
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97370538
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83852149
17ELK1_19687146_ChIP-ChIP_HELA_Human2.80340027
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77903505
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.73819599
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.57832822
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53147185
22* VDR_23849224_ChIP-Seq_CD4+_Human2.39541819
23FOXP3_21729870_ChIP-Seq_TREG_Human2.30307733
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30003964
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25090253
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22863849
27TTF2_22483619_ChIP-Seq_HELA_Human2.22688559
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.19930910
29DCP1A_22483619_ChIP-Seq_HELA_Human2.16298110
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05863583
31AR_21909140_ChIP-Seq_LNCAP_Human2.05816347
32XRN2_22483619_ChIP-Seq_HELA_Human2.04769271
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02730508
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.96492141
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87074896
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.84137890
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81767790
38* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81326114
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77627773
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.77202797
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76967606
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.75656098
43GABP_19822575_ChIP-Seq_HepG2_Human1.74212935
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72075210
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71680408
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.71475037
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70082814
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66604920
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58487912
50* MYC_18940864_ChIP-ChIP_HL60_Human1.57884956
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52090577
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.49528874
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.47569973
54ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.38521749
55NANOG_16153702_ChIP-ChIP_HESCs_Human1.34369693
56EWS_26573619_Chip-Seq_HEK293_Human1.31535242
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30939385
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.29860551
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.25659465
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20719432
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.20670663
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18878331
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.15706147
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14252807
65FUS_26573619_Chip-Seq_HEK293_Human1.14132577
66* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11815458
67KDM5A_27292631_Chip-Seq_BREAST_Human1.07946847
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05272980
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02514643
70SOX17_20123909_ChIP-Seq_XEN_Mouse1.02024991
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99619937
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99563284
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99563284
74KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99563284
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99092086
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98598401
77TP63_19390658_ChIP-ChIP_HaCaT_Human0.96833063
78VDR_22108803_ChIP-Seq_LS180_Human0.96379705
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94827104
80CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94739866
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94541272
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94329504
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93913552
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92697676
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88987471
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88508113
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85864194
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82782894
89FLI1_27457419_Chip-Seq_LIVER_Mouse0.81839807
90ZNF274_21170338_ChIP-Seq_K562_Hela0.81742050
91NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81437875
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80588383
93IRF1_19129219_ChIP-ChIP_H3396_Human0.80351962
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.79525532
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74551092
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70398590
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68920571
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.68614387
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.68532884
100* ELF5_23300383_ChIP-Seq_T47D_Human0.68368178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.34698514
2MP0004957_abnormal_blastocyst_morpholog4.22199580
3MP0010094_abnormal_chromosome_stability4.11599088
4MP0008058_abnormal_DNA_repair4.07947652
5MP0009379_abnormal_foot_pigmentation3.74994113
6MP0003111_abnormal_nucleus_morphology3.33452671
7MP0003077_abnormal_cell_cycle3.23384392
8MP0006292_abnormal_olfactory_placode3.01323698
9MP0003718_maternal_effect3.00450702
10MP0008932_abnormal_embryonic_tissue2.87962989
11MP0003941_abnormal_skin_development2.87261514
12MP0008877_abnormal_DNA_methylation2.57167642
13MP0008057_abnormal_DNA_replication2.57130451
14MP0008007_abnormal_cellular_replicative2.49275120
15MP0010030_abnormal_orbit_morphology2.38228182
16MP0003806_abnormal_nucleotide_metabolis2.33221825
17MP0003186_abnormal_redox_activity2.23996190
18MP0001293_anophthalmia2.10129335
19MP0009697_abnormal_copulation1.91897476
20MP0003786_premature_aging1.87737217
21MP0002938_white_spotting1.85685690
22MP0006035_abnormal_mitochondrial_morpho1.70373895
23MP0006036_abnormal_mitochondrial_physio1.64982425
24MP0001730_embryonic_growth_arrest1.64820962
25MP0000350_abnormal_cell_proliferation1.63149736
26MP0003567_abnormal_fetal_cardiomyocyte1.62503160
27MP0003890_abnormal_embryonic-extraembry1.61456417
28MP0008789_abnormal_olfactory_epithelium1.52624590
29MP0002210_abnormal_sex_determination1.52001784
30MP0003315_abnormal_perineum_morphology1.46904819
31MP0001697_abnormal_embryo_size1.44469652
32MP0003937_abnormal_limbs/digits/tail_de1.43445216
33MP0005380_embryogenesis_phenotype1.38425548
34MP0001672_abnormal_embryogenesis/_devel1.38425548
35MP0006072_abnormal_retinal_apoptosis1.35981569
36MP0002085_abnormal_embryonic_tissue1.34259352
37MP0002084_abnormal_developmental_patter1.34206000
38MP0001529_abnormal_vocalization1.34129537
39MP0001286_abnormal_eye_development1.25310204
40MP0001929_abnormal_gametogenesis1.24980558
41MP0003136_yellow_coat_color1.24543364
42MP0000372_irregular_coat_pigmentation1.23752702
43MP0001145_abnormal_male_reproductive1.22066914
44MP0000358_abnormal_cell_content/1.20746569
45MP0002160_abnormal_reproductive_system1.19279531
46MP0002233_abnormal_nose_morphology1.19003996
47MP0009672_abnormal_birth_weight1.18567948
48MP0005084_abnormal_gallbladder_morpholo1.16839882
49MP0002080_prenatal_lethality1.16785469
50MP0000653_abnormal_sex_gland1.15670681
51MP0003984_embryonic_growth_retardation1.15415503
52MP0002088_abnormal_embryonic_growth/wei1.12420012
53MP0000313_abnormal_cell_death1.10545887
54MP0002697_abnormal_eye_size1.10129589
55MP0003123_paternal_imprinting1.07991705
56MP0002234_abnormal_pharynx_morphology1.07116171
57MP0003119_abnormal_digestive_system1.06859347
58MP0002102_abnormal_ear_morphology1.04485122
59MP0000049_abnormal_middle_ear1.02882759
60MP0002837_dystrophic_cardiac_calcinosis0.99377196
61MP0005499_abnormal_olfactory_system0.98080864
62MP0005394_taste/olfaction_phenotype0.98080864
63MP0004215_abnormal_myocardial_fiber0.95092938
64MP0010307_abnormal_tumor_latency0.93027122
65MP0003121_genomic_imprinting0.91518175
66MP0002163_abnormal_gland_morphology0.89147821
67MP0001188_hyperpigmentation0.88917921
68MP0005395_other_phenotype0.86624721
69MP0008995_early_reproductive_senescence0.85267132
70MP0003950_abnormal_plasma_membrane0.85181152
71MP0002111_abnormal_tail_morphology0.81890148
72MP0001119_abnormal_female_reproductive0.80969463
73MP0005408_hypopigmentation0.80544605
74MP0000490_abnormal_crypts_of0.80439209
75MP0002796_impaired_skin_barrier0.78595604
76MP0009250_abnormal_appendicular_skeleto0.75868096
77MP0000631_abnormal_neuroendocrine_gland0.74589937
78MP0000537_abnormal_urethra_morphology0.74289895
79MP0005501_abnormal_skin_physiology0.74254168
80MP0004147_increased_porphyrin_level0.74043979
81MP0002751_abnormal_autonomic_nervous0.73936239
82MP0004197_abnormal_fetal_growth/weight/0.72559506
83MP0005389_reproductive_system_phenotype0.72221536
84MP0000762_abnormal_tongue_morphology0.71042401
85MP0003698_abnormal_male_reproductive0.70151525
86MP0005075_abnormal_melanosome_morpholog0.69515754
87MP0003755_abnormal_palate_morphology0.68825786
88MP0009703_decreased_birth_body0.67980690
89MP0001881_abnormal_mammary_gland0.64737555
90MP0002086_abnormal_extraembryonic_tissu0.64662749
91MP0002019_abnormal_tumor_incidence0.64521533
92MP0010352_gastrointestinal_tract_polyps0.64095187
93MP0002161_abnormal_fertility/fecundity0.63219601
94MP0001764_abnormal_homeostasis0.62741106
95MP0000647_abnormal_sebaceous_gland0.62020781
96MP0003936_abnormal_reproductive_system0.60361933
97MP0005391_vision/eye_phenotype0.58885947
98MP0003699_abnormal_female_reproductive0.58299298
99MP0002277_abnormal_respiratory_mucosa0.56241021
100MP0002092_abnormal_eye_morphology0.55172222

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.83197849
2Reticulocytopenia (HP:0001896)4.67212741
3Acute encephalopathy (HP:0006846)4.39097116
4Abnormal mitochondria in muscle tissue (HP:0008316)4.36612129
5Abnormality of cells of the erythroid lineage (HP:0012130)4.23078561
6Macrocytic anemia (HP:0001972)4.20000207
7Mitochondrial inheritance (HP:0001427)4.00966792
8Increased hepatocellular lipid droplets (HP:0006565)3.99568510
9Progressive macrocephaly (HP:0004481)3.91061071
10Abnormal number of erythroid precursors (HP:0012131)3.87824729
11Increased CSF lactate (HP:0002490)3.79762922
12Lipid accumulation in hepatocytes (HP:0006561)3.52833059
13Colon cancer (HP:0003003)3.49370904
14Hepatocellular necrosis (HP:0001404)3.44114331
15Cerebral edema (HP:0002181)3.35492379
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28657631
17Hepatic necrosis (HP:0002605)3.22555083
18Chromsome breakage (HP:0040012)3.19910884
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.09772229
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.09772229
21Abnormality of the labia minora (HP:0012880)3.03309534
22Renal Fanconi syndrome (HP:0001994)2.94344420
233-Methylglutaconic aciduria (HP:0003535)2.90107535
24Aplastic anemia (HP:0001915)2.87447984
25Microvesicular hepatic steatosis (HP:0001414)2.84643201
26Pallor (HP:0000980)2.83202948
27Meckel diverticulum (HP:0002245)2.82009085
28Increased serum lactate (HP:0002151)2.74009032
29Stenosis of the external auditory canal (HP:0000402)2.73802421
30Type I transferrin isoform profile (HP:0003642)2.69427399
31Abnormality of the ileum (HP:0001549)2.66618745
32Lactic acidosis (HP:0003128)2.61596479
33Multiple enchondromatosis (HP:0005701)2.55605500
34Abnormal lung lobation (HP:0002101)2.53259440
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.52651555
36Reduced antithrombin III activity (HP:0001976)2.51485076
37Increased intramyocellular lipid droplets (HP:0012240)2.50256033
38Abnormality of chromosome stability (HP:0003220)2.48666467
39Abnormality of the preputium (HP:0100587)2.47433153
40Abnormality of methionine metabolism (HP:0010901)2.45571520
41Septo-optic dysplasia (HP:0100842)2.45052912
42Aplasia/Hypoplasia of the sacrum (HP:0008517)2.42814365
43Increased serum pyruvate (HP:0003542)2.41974148
44Triphalangeal thumb (HP:0001199)2.41861447
45Exercise intolerance (HP:0003546)2.40934096
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37735767
47Abnormality of alanine metabolism (HP:0010916)2.37702231
48Hyperalaninemia (HP:0003348)2.37702231
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.37702231
50Respiratory failure (HP:0002878)2.36167878
51Leukodystrophy (HP:0002415)2.35913600
52Methylmalonic acidemia (HP:0002912)2.34568456
53Respiratory difficulties (HP:0002880)2.34532013
54Abnormality of serum amino acid levels (HP:0003112)2.34058534
55Hyperglycinemia (HP:0002154)2.29304361
56Birth length less than 3rd percentile (HP:0003561)2.27253807
57Exertional dyspnea (HP:0002875)2.22739419
58Duodenal stenosis (HP:0100867)2.19969485
59Small intestinal stenosis (HP:0012848)2.19969485
60Abnormal protein glycosylation (HP:0012346)2.16461421
61Abnormal glycosylation (HP:0012345)2.16461421
62Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16461421
63Abnormal protein N-linked glycosylation (HP:0012347)2.16461421
64Facial cleft (HP:0002006)2.15527450
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14644986
66Absent septum pellucidum (HP:0001331)2.14528709
67Pancytopenia (HP:0001876)2.12620723
68Megaloblastic anemia (HP:0001889)2.11941919
69Oral leukoplakia (HP:0002745)2.06993054
70Abnormality of glycolysis (HP:0004366)2.05343965
71Optic disc pallor (HP:0000543)2.02430119
72Horseshoe kidney (HP:0000085)2.01419317
73Methylmalonic aciduria (HP:0012120)2.01141828
74Congenital, generalized hypertrichosis (HP:0004540)2.00615491
75Abnormality of the septum pellucidum (HP:0007375)2.00510682
76Lethargy (HP:0001254)2.00154502
77Abnormality of the duodenum (HP:0002246)1.98002886
78Absent thumb (HP:0009777)1.97715642
79Cleft eyelid (HP:0000625)1.94578321
80Degeneration of anterior horn cells (HP:0002398)1.92273389
81Abnormality of the anterior horn cell (HP:0006802)1.92273389
82Nephroblastoma (Wilms tumor) (HP:0002667)1.91066959
83Increased muscle lipid content (HP:0009058)1.90361803
84Neoplasm of the colon (HP:0100273)1.89937182
85Amniotic constriction ring (HP:0009775)1.89472251
86Abnormality of placental membranes (HP:0011409)1.89472251
87Myelodysplasia (HP:0002863)1.88492403
88Sensory axonal neuropathy (HP:0003390)1.87336954
89Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86915861
90Supernumerary spleens (HP:0009799)1.83529230
91Embryonal renal neoplasm (HP:0011794)1.81722722
92Abnormality of renal resorption (HP:0011038)1.81535931
93Sparse eyelashes (HP:0000653)1.79200413
94Cerebral hypomyelination (HP:0006808)1.78421931
95Carpal bone hypoplasia (HP:0001498)1.73654435
96Hyperglycinuria (HP:0003108)1.73459387
97Premature ovarian failure (HP:0008209)1.72423254
98Absent radius (HP:0003974)1.71094686
99Rhabdomyosarcoma (HP:0002859)1.66288787
100Abnormality of glycine metabolism (HP:0010895)1.65419844

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.39398160
2VRK24.26314294
3CDC73.77443813
4PBK3.11437977
5SRPK12.96385563
6TTK2.76201126
7NEK12.71828938
8STK162.63400512
9EIF2AK32.54571469
10ZAK2.41581407
11VRK12.27339780
12TSSK62.22933148
13NME22.22278203
14PLK32.22171444
15MST42.19839618
16EIF2AK12.19587779
17PLK42.07222842
18TAF11.99250385
19MKNK11.79509319
20CDK191.75416087
21NUAK11.72520608
22WEE11.72106958
23PASK1.68187920
24PLK11.65619018
25TRIM281.63524492
26MAP3K121.63268980
27NME11.57709208
28BRSK21.49153382
29MKNK21.44708204
30CHEK21.26235566
31AURKB1.25194485
32BMPR1B1.15203430
33STK38L1.13080196
34PNCK1.04340180
35ATR1.01185717
36SCYL21.00812465
37DYRK21.00176360
38WNK30.98009003
39TLK10.97000865
40PDK20.95673097
41NEK20.92833674
42BRSK10.91522321
43STK240.89912725
44EIF2AK20.89771846
45STK30.89321727
46CDK80.87013963
47PAK40.86063880
48AURKA0.84481885
49STK40.84467248
50ACVR1B0.84160011
51RPS6KB20.79644022
52MYLK0.78678362
53TNIK0.78635661
54DYRK30.76708004
55TGFBR10.75845347
56CHEK10.74775299
57CSNK2A20.73973710
58BRAF0.72662758
59CDK70.71675894
60LIMK10.70841939
61ATM0.70248500
62CSNK2A10.69016495
63BCKDK0.67579702
64CSNK1G10.67096841
65ERBB40.65951017
66ILK0.64678060
67FLT30.63394087
68CCNB10.61476065
69DAPK10.59264841
70MAP4K20.56152338
71KDR0.55601155
72PLK20.54769441
73INSRR0.52277687
74CSNK1G30.52252209
75MAP3K100.52105525
76DMPK0.50199702
77ARAF0.49601869
78DAPK30.49030460
79CSNK1E0.46127433
80RPS6KA40.45010136
81CSNK1G20.44850189
82ALK0.41399497
83TIE10.40993879
84CLK10.40373845
85TESK20.40175976
86PRKCI0.40103107
87CDK10.39139108
88MAP3K80.37824167
89RPS6KA50.36851600
90CDK20.36550415
91GRK10.33644645
92LRRK20.32793856
93ABL20.32350681
94MAP3K40.32312268
95OXSR10.31378304
96PAK10.31368110
97FGFR10.30917748
98CDK30.28022872
99PRKDC0.27771210
100CDK90.27103506

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.79610614
2Proteasome_Homo sapiens_hsa030504.24041640
3Mismatch repair_Homo sapiens_hsa034303.73969967
4DNA replication_Homo sapiens_hsa030303.69145645
5Oxidative phosphorylation_Homo sapiens_hsa001903.29415191
6Parkinsons disease_Homo sapiens_hsa050122.98281647
7RNA polymerase_Homo sapiens_hsa030202.92041603
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.87368096
9Protein export_Homo sapiens_hsa030602.73736399
10Homologous recombination_Homo sapiens_hsa034402.63274676
11Spliceosome_Homo sapiens_hsa030402.36275752
12Base excision repair_Homo sapiens_hsa034102.33611806
13Non-homologous end-joining_Homo sapiens_hsa034502.30924039
14Nucleotide excision repair_Homo sapiens_hsa034202.27016067
15Huntingtons disease_Homo sapiens_hsa050162.26707586
16RNA transport_Homo sapiens_hsa030132.16165331
17One carbon pool by folate_Homo sapiens_hsa006701.93888607
18Basal transcription factors_Homo sapiens_hsa030221.89580599
19Alzheimers disease_Homo sapiens_hsa050101.86738610
20RNA degradation_Homo sapiens_hsa030181.82531508
21Cell cycle_Homo sapiens_hsa041101.80244687
22Pyrimidine metabolism_Homo sapiens_hsa002401.79393113
23Fanconi anemia pathway_Homo sapiens_hsa034601.76845302
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.74888390
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53321005
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.53211975
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.45169690
28Propanoate metabolism_Homo sapiens_hsa006401.39057686
29Pyruvate metabolism_Homo sapiens_hsa006201.35683110
30Purine metabolism_Homo sapiens_hsa002301.33209166
31Cardiac muscle contraction_Homo sapiens_hsa042601.30769469
32Folate biosynthesis_Homo sapiens_hsa007901.29345296
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27349478
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17251637
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.17243695
36Fatty acid elongation_Homo sapiens_hsa000621.16711960
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09232019
38Glutathione metabolism_Homo sapiens_hsa004801.03296439
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02831322
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00533821
41mRNA surveillance pathway_Homo sapiens_hsa030150.94915234
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94594490
43Carbon metabolism_Homo sapiens_hsa012000.88548310
44Biosynthesis of amino acids_Homo sapiens_hsa012300.82656126
45Selenocompound metabolism_Homo sapiens_hsa004500.82110311
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79159455
47Oocyte meiosis_Homo sapiens_hsa041140.77159170
48p53 signaling pathway_Homo sapiens_hsa041150.74139145
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73109474
50Steroid biosynthesis_Homo sapiens_hsa001000.70508005
51Metabolic pathways_Homo sapiens_hsa011000.69020338
52Sulfur metabolism_Homo sapiens_hsa009200.64013227
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63393635
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57144772
55Sulfur relay system_Homo sapiens_hsa041220.53441411
56Vitamin B6 metabolism_Homo sapiens_hsa007500.50938007
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50720059
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50689946
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46838312
60N-Glycan biosynthesis_Homo sapiens_hsa005100.44684130
61Systemic lupus erythematosus_Homo sapiens_hsa053220.43425855
62Epstein-Barr virus infection_Homo sapiens_hsa051690.41963448
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39851190
64Peroxisome_Homo sapiens_hsa041460.39000845
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.37812332
66TGF-beta signaling pathway_Homo sapiens_hsa043500.34462507
67Butanoate metabolism_Homo sapiens_hsa006500.33959830
68Basal cell carcinoma_Homo sapiens_hsa052170.33788072
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30744503
70Fatty acid degradation_Homo sapiens_hsa000710.30710281
71Vitamin digestion and absorption_Homo sapiens_hsa049770.30049960
72Pentose phosphate pathway_Homo sapiens_hsa000300.30011176
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28350946
74Arginine and proline metabolism_Homo sapiens_hsa003300.28210893
75Regulation of autophagy_Homo sapiens_hsa041400.28005325
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27349452
77beta-Alanine metabolism_Homo sapiens_hsa004100.26822755
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25095010
79Caffeine metabolism_Homo sapiens_hsa002320.25067426
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.24801116
81Wnt signaling pathway_Homo sapiens_hsa043100.23278209
82Tryptophan metabolism_Homo sapiens_hsa003800.23084285
83Hedgehog signaling pathway_Homo sapiens_hsa043400.22372154
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20777189
85Chemical carcinogenesis_Homo sapiens_hsa052040.20769455
86Fatty acid metabolism_Homo sapiens_hsa012120.19525684
87Hippo signaling pathway_Homo sapiens_hsa043900.19078732
88Tyrosine metabolism_Homo sapiens_hsa003500.18425331
89Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17908848
90Retinol metabolism_Homo sapiens_hsa008300.17632911
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.17067368
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16147073
93Alcoholism_Homo sapiens_hsa050340.16116608
94Phototransduction_Homo sapiens_hsa047440.14362701
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.11302646
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11098710
97Fat digestion and absorption_Homo sapiens_hsa049750.11066331
98Galactose metabolism_Homo sapiens_hsa000520.08907432
99Nitrogen metabolism_Homo sapiens_hsa009100.08328903
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.06723162

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »