ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	rRNA methylation (GO:0031167)	4.71153022
2	folic acid-containing compound biosynthetic process (GO:0009396)	4.69704867
3	rRNA modification (GO:0000154)	4.59343904
4	ribosome assembly (GO:0042255)	4.04657099
5	purine nucleotide salvage (GO:0032261)	3.71498135
6	IMP biosynthetic process (GO:0006188)	3.64543382
7	regulation of vitamin D biosynthetic process (GO:0060556)	3.32290707
8	IMP metabolic process (GO:0046040)	3.28676901
9	chromosome condensation (GO:0030261)	3.28264912
10	DNA strand elongation involved in DNA replication (GO:0006271)	3.23387602
11	NIK/NF-kappaB signaling (GO:0038061)	3.22668141
12	telomere maintenance via semi-conservative replication (GO:0032201)	3.14804634
13	DNA strand elongation (GO:0022616)	3.13233815
14	pteridine-containing compound biosynthetic process (GO:0042559)	3.03436138
15	polyamine biosynthetic process (GO:0006596)	3.02043854
16	transcription from mitochondrial promoter (GO:0006390)	3.00396684
17	ribosome biogenesis (GO:0042254)	2.96330526
18	mitochondrial RNA metabolic process (GO:0000959)	2.94059495
19	rRNA transcription (GO:0009303)	2.89878006
20	mitotic chromosome condensation (GO:0007076)	2.89492333
21	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.86101808
22	DNA replication initiation (GO:0006270)	2.80566749
23	protein complex localization (GO:0031503)	2.78696201
24	DNA replication-dependent nucleosome organization (GO:0034723)	2.73826670
25	DNA replication-dependent nucleosome assembly (GO:0006335)	2.73826670
26	binding of sperm to zona pellucida (GO:0007339)	2.73260111
27	DNA packaging (GO:0006323)	2.72977637
28	establishment of viral latency (GO:0019043)	2.69090381
29	mitotic metaphase plate congression (GO:0007080)	2.69077584
30	histone H3-K36 demethylation (GO:0070544)	2.66221556
31	DNA double-strand break processing (GO:0000729)	2.63617449
32	regulation of autophagic vacuole assembly (GO:2000785)	2.62954502
33	negative regulation of necroptotic process (GO:0060546)	2.55869179
34	telomere maintenance via recombination (GO:0000722)	2.53841246
35	histone exchange (GO:0043486)	2.52970854
36	nucleotide salvage (GO:0043173)	2.50969922
37	RNA methylation (GO:0001510)	2.44429050
38	mitotic nuclear envelope disassembly (GO:0007077)	2.42028692
39	regulation of vitamin metabolic process (GO:0030656)	2.41142759
40	response to peptidoglycan (GO:0032494)	2.40254309
41	cellular response to arsenic-containing substance (GO:0071243)	2.39970788
42	TOR signaling (GO:0031929)	2.39024268
43	protein localization to chromosome, centromeric region (GO:0071459)	2.36260118
44	hepatocyte apoptotic process (GO:0097284)	2.35742118
45	establishment of integrated proviral latency (GO:0075713)	2.31705864
46	pseudouridine synthesis (GO:0001522)	2.31276809
47	T cell migration (GO:0072678)	2.30954638
48	T cell lineage commitment (GO:0002360)	2.30586414
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.29398767
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.29398767
51	protein-DNA complex disassembly (GO:0032986)	2.28826164
52	nucleosome disassembly (GO:0006337)	2.28826164
53	L-alpha-amino acid transmembrane transport (GO:1902475)	2.28475276
54	positive regulation of gamma-delta T cell activation (GO:0046645)	2.27144448
55	rRNA processing (GO:0006364)	2.26868378
56	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.26863196
57	nuclear pore organization (GO:0006999)	2.26859206
58	negative regulation of interleukin-12 production (GO:0032695)	2.26785430
59	CENP-A containing nucleosome assembly (GO:0034080)	2.26058696
60	spermatid development (GO:0007286)	2.25598345
61	V(D)J recombination (GO:0033151)	2.23420689
62	mitotic recombination (GO:0006312)	2.23312124
63	regulation of vacuole organization (GO:0044088)	2.21710059
64	purine-containing compound salvage (GO:0043101)	2.21054119
65	necroptotic process (GO:0070266)	2.21041588
66	sperm-egg recognition (GO:0035036)	2.20646976
67	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.20515534
68	chromatin remodeling at centromere (GO:0031055)	2.20432176
69	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.20330524
70	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.17465914
71	DNA catabolic process, exonucleolytic (GO:0000738)	2.16755885
72	single strand break repair (GO:0000012)	2.16490244
73	negative regulation of macroautophagy (GO:0016242)	2.16007305
74	nuclear envelope disassembly (GO:0051081)	2.15911945
75	membrane disassembly (GO:0030397)	2.15911945
76	cellular response to lithium ion (GO:0071285)	2.15606353
77	positive regulation of protein homooligomerization (GO:0032464)	2.15262752
78	somatic cell DNA recombination (GO:0016444)	2.14762255
79	somatic diversification of immune receptors via germline recombination within a single locus (GO:000	2.14762255
80	ribonucleoprotein complex biogenesis (GO:0022613)	2.14091443
81	immunoglobulin mediated immune response (GO:0016064)	2.13564423
82	positive regulation of B cell differentiation (GO:0045579)	2.12774140
83	rRNA metabolic process (GO:0016072)	2.12599758
84	positive regulation of T cell migration (GO:2000406)	2.12168864
85	T cell apoptotic process (GO:0070231)	2.11373362
86	B cell mediated immunity (GO:0019724)	2.11112696
87	homocysteine metabolic process (GO:0050667)	2.10530475
88	metaphase plate congression (GO:0051310)	2.10482013
89	peptidyl-histidine modification (GO:0018202)	2.09936421
90	mRNA cleavage (GO:0006379)	2.09841027
91	DNA ligation (GO:0006266)	2.09299556
92	myeloid dendritic cell activation (GO:0001773)	2.09234707
93	negative regulation of defense response to virus (GO:0050687)	2.08855002
94	cellular response to interleukin-4 (GO:0071353)	2.08769444
95	cellular response to zinc ion (GO:0071294)	2.08730011
96	regulation of helicase activity (GO:0051095)	2.08553488
97	glycosphingolipid catabolic process (GO:0046479)	2.07926613
98	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.07536816
99	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.07536816
100	alternative mRNA splicing, via spliceosome (GO:0000380)	2.07339337

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.35383457
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.13581252
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.94186918
4	MYC_22102868_ChIP-Seq_BL_Human	2.69668385
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.66884554
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.65681503
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.64754880
8	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.56469262
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.37208850
10	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.35704816
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.29968332
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.25045495
13	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	2.20808713
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.15863605
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.10847369
16	VDR_21846776_ChIP-Seq_THP-1_Human	2.10452573
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.03747913
18	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.00639879
19	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.96892865
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90177223
21	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.89452834
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.88677609
23	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.81758210
24	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.79465092
25	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.76091761
26	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.75919879
27	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.71449021
28	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.70367985
29	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.69170639
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.68599578
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.68568581
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.67597068
33	SPI1_23547873_ChIP-Seq_NB4_Human	1.64396072
34	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.63461390
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.61856001
36	VDR_23849224_ChIP-Seq_CD4+_Human	1.55798313
37	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.54581179
38	CIITA_25753668_ChIP-Seq_RAJI_Human	1.52258559
39	MAF_26560356_Chip-Seq_TH2_Human	1.52201043
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.51286889
41	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.50114327
42	TFEB_21752829_ChIP-Seq_HELA_Human	1.48783548
43	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.47941801
44	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.47848479
45	MYB_26560356_Chip-Seq_TH2_Human	1.47168559
46	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.46835358
47	KDM5A_27292631_Chip-Seq_BREAST_Human	1.45678530
48	MYB_26560356_Chip-Seq_TH1_Human	1.45477231
49	MAF_26560356_Chip-Seq_TH1_Human	1.43147602
50	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.42202155
51	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.41866003
52	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.41520317
53	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.41110072
54	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.41006904
55	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.40760245
56	XRN2_22483619_ChIP-Seq_HELA_Human	1.40344563
57	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.38735566
58	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.38509234
59	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.37517599
60	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.34522962
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34285760
62	UTX_26944678_Chip-Seq_JUKART_Human	1.34140252
63	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.32251289
64	AR_21909140_ChIP-Seq_LNCAP_Human	1.31299518
65	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.30854996
66	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.29821158
67	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.26226825
68	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.25581079
69	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24315756
70	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.22798872
71	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.21027487
72	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.20227023
73	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.17317359
74	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.16728809
75	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.16624951
76	VDR_24763502_ChIP-Seq_THP-1_Human	1.15506211
77	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.14967731
78	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.14819210
79	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.13728115
80	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.12888236
81	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.12583545
82	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12166023
83	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.11741994
84	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.11235905
85	ZNF263_19887448_ChIP-Seq_K562_Human	1.09906701
86	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.05939947
87	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.05223889
88	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.04628465
89	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.04404957
90	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.04036229
91	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.02041521
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.01605284
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.99598413
94	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.98634768
95	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.98604639
96	ELK1_19687146_ChIP-ChIP_HELA_Human	0.97500388
97	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.97304977
98	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.96484318
99	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.95787726
100	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.95648106

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.31951398
2	MP0003763_abnormal_thymus_physiology	2.87986907
3	MP0002254_reproductive_system_inflammat	2.80359090
4	MP0003693_abnormal_embryo_hatching	2.74432364
5	MP0005410_abnormal_fertilization	2.65058639
6	MP0010094_abnormal_chromosome_stability	2.57478625
7	MP0000685_abnormal_immune_system	2.23294486
8	MP0003077_abnormal_cell_cycle	2.20892600
9	MP0009333_abnormal_splenocyte_physiolog	2.20468308
10	MP0003111_abnormal_nucleus_morphology	2.20033170
11	MP0005058_abnormal_lysosome_morphology	2.19162839
12	MP0001835_abnormal_antigen_presentation	2.18949517
13	MP0005671_abnormal_response_to	2.08915841
14	MP0002148_abnormal_hypersensitivity_rea	2.06707696
15	MP0005000_abnormal_immune_tolerance	2.06514135
16	MP0001800_abnormal_humoral_immune	1.99955100
17	MP0009840_abnormal_foam_cell	1.96674746
18	MP0004957_abnormal_blastocyst_morpholog	1.96350638
19	MP0002132_abnormal_respiratory_system	1.91023321
20	MP0002452_abnormal_antigen_presenting	1.85954273
21	MP0003436_decreased_susceptibility_to	1.83073586
22	MP0002398_abnormal_bone_marrow	1.79801742
23	MP0005387_immune_system_phenotype	1.78494072
24	MP0001790_abnormal_immune_system	1.78494072
25	MP0001849_ear_inflammation	1.75151360
26	MP0002723_abnormal_immune_serum	1.74700290
27	MP0002420_abnormal_adaptive_immunity	1.71915033
28	MP0000703_abnormal_thymus_morphology	1.69931875
29	MP0001819_abnormal_immune_cell	1.69746487
30	MP0002138_abnormal_hepatobiliary_system	1.66178903
31	MP0009785_altered_susceptibility_to	1.65566383
32	MP0005451_abnormal_body_composition	1.58531839
33	MP0002722_abnormal_immune_system	1.57091854
34	MP0003315_abnormal_perineum_morphology	1.55923250
35	MP0002396_abnormal_hematopoietic_system	1.53385907
36	MP0002419_abnormal_innate_immunity	1.53185183
37	MP0000716_abnormal_immune_system	1.48023904
38	MP0005025_abnormal_response_to	1.47315657
39	MP0008057_abnormal_DNA_replication	1.46921510
40	MP0000689_abnormal_spleen_morphology	1.40936845
41	MP0008058_abnormal_DNA_repair	1.40598499
42	MP0000490_abnormal_crypts_of	1.38013840
43	MP0008007_abnormal_cellular_replicative	1.36331401
44	MP0002429_abnormal_blood_cell	1.36219692
45	MP0001853_heart_inflammation	1.34316003
46	MP0002163_abnormal_gland_morphology	1.32407326
47	MP0003786_premature_aging	1.30558097
48	MP0004233_abnormal_muscle_weight	1.28974431
49	MP0003303_peritoneal_inflammation	1.26545930
50	MP0002405_respiratory_system_inflammati	1.23609261
51	MP0008995_early_reproductive_senescence	1.22863159
52	MP0002019_abnormal_tumor_incidence	1.22100096
53	MP0001929_abnormal_gametogenesis	1.21183429
54	MP0005310_abnormal_salivary_gland	1.20808936
55	MP0009697_abnormal_copulation	1.20124421
56	MP0002139_abnormal_hepatobiliary_system	1.18761302
57	MP0005647_abnormal_sex_gland	1.16800719
58	MP0001845_abnormal_inflammatory_respons	1.16762130
59	MP0004947_skin_inflammation	1.16552052
60	MP0000465_gastrointestinal_hemorrhage	1.16164841
61	MP0009278_abnormal_bone_marrow	1.15349935
62	MP0004381_abnormal_hair_follicle	1.13682685
63	MP0005379_endocrine/exocrine_gland_phen	1.09905037
64	MP0000313_abnormal_cell_death	1.09435340
65	MP0004808_abnormal_hematopoietic_stem	1.09271015
66	MP0002166_altered_tumor_susceptibility	1.07973906
67	MP0003724_increased_susceptibility_to	1.07864169
68	MP0006035_abnormal_mitochondrial_morpho	1.07839437
69	MP0003172_abnormal_lysosome_physiology	1.07075299
70	MP0001873_stomach_inflammation	1.05445146
71	MP0004185_abnormal_adipocyte_glucose	1.04578661
72	MP0010307_abnormal_tumor_latency	1.03956851
73	MP0000858_altered_metastatic_potential	1.03117732
74	MP0005075_abnormal_melanosome_morpholog	1.02681874
75	MP0004264_abnormal_extraembryonic_tissu	1.02391237
76	MP0001730_embryonic_growth_arrest	0.96685611
77	MP0008004_abnormal_stomach_pH	0.96441634
78	MP0002796_impaired_skin_barrier	0.96105522
79	MP0001764_abnormal_homeostasis	0.95223863
80	MP0000678_abnormal_parathyroid_gland	0.94978293
81	MP0008469_abnormal_protein_level	0.94819609
82	MP0002006_tumorigenesis	0.93831719
83	MP0003718_maternal_effect	0.93428635
84	MP0000350_abnormal_cell_proliferation	0.93018958
85	MP0003453_abnormal_keratinocyte_physiol	0.90775671
86	MP0006036_abnormal_mitochondrial_physio	0.90645291
87	MP0001661_extended_life_span	0.88058624
88	MP0003183_abnormal_peptide_metabolism	0.88029605
89	MP0002160_abnormal_reproductive_system	0.87544611
90	MP0005397_hematopoietic_system_phenotyp	0.83736765
91	MP0001545_abnormal_hematopoietic_system	0.83736765
92	MP0002998_abnormal_bone_remodeling	0.83390621
93	MP0003698_abnormal_male_reproductive	0.82800925
94	MP0005360_urolithiasis	0.81757300
95	MP0001919_abnormal_reproductive_system	0.80834403
96	MP0000358_abnormal_cell_content/	0.80162281
97	MP0003191_abnormal_cellular_cholesterol	0.79834412
98	MP0002210_abnormal_sex_determination	0.79798029
99	MP0010155_abnormal_intestine_physiology	0.78197798
100	MP0001145_abnormal_male_reproductive	0.77321261

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	3.79899109
2	Abnormality of glycolipid metabolism (HP:0010969)	3.59953462
3	Abnormality of liposaccharide metabolism (HP:0010968)	3.59953462
4	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.59953462
5	IgA deficiency (HP:0002720)	3.58251560
6	Recurrent viral infections (HP:0004429)	2.97449768
7	Abnormality of the columella (HP:0009929)	2.90833564
8	Thoracic kyphosis (HP:0002942)	2.88965348
9	Increased IgM level (HP:0003496)	2.87927440
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.82810563
11	Granulocytopenia (HP:0001913)	2.80456455
12	Colitis (HP:0002583)	2.78415047
13	IgG deficiency (HP:0004315)	2.73592061
14	Abnormal umbilical cord blood vessels (HP:0011403)	2.73504697
15	Single umbilical artery (HP:0001195)	2.73504697
16	Abnormality of the fetal cardiovascular system (HP:0010948)	2.73504697
17	Hypergonadotropic hypogonadism (HP:0000815)	2.63927441
18	Abnormality of DNA repair (HP:0003254)	2.62079926
19	Recurrent sinusitis (HP:0011108)	2.55314599
20	Fatigue (HP:0012378)	2.55254865
21	Sensory axonal neuropathy (HP:0003390)	2.55143751
22	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.54481767
23	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.53990059
24	Abnormality of alanine metabolism (HP:0010916)	2.53990059
25	Hyperalaninemia (HP:0003348)	2.53990059
26	Mediastinal lymphadenopathy (HP:0100721)	2.48484716
27	B lymphocytopenia (HP:0010976)	2.48238483
28	Autoimmune thrombocytopenia (HP:0001973)	2.47125385
29	Autoimmune hemolytic anemia (HP:0001890)	2.47017248
30	Chromsome breakage (HP:0040012)	2.46123816
31	Abnormality of lateral ventricle (HP:0030047)	2.44464038
32	Myocardial infarction (HP:0001658)	2.42673590
33	Recurrent abscess formation (HP:0002722)	2.42663355
34	Gastrointestinal stroma tumor (HP:0100723)	2.42163389
35	Carpal bone hypoplasia (HP:0001498)	2.35905683
36	Abnormality of the umbilical cord (HP:0010881)	2.35334751
37	IgM deficiency (HP:0002850)	2.32602517
38	Resting tremor (HP:0002322)	2.29473224
39	Premature ovarian failure (HP:0008209)	2.28244538
40	Combined immunodeficiency (HP:0005387)	2.27459429
41	Progressive muscle weakness (HP:0003323)	2.26483424
42	Abnormality of the thoracic spine (HP:0100711)	2.26301316
43	Lymphopenia (HP:0001888)	2.26100104
44	Constricted visual fields (HP:0001133)	2.24721127
45	Abnormality of cells of the lymphoid lineage (HP:0012140)	2.21454353
46	Stomatitis (HP:0010280)	2.20227011
47	Abnormality of the preputium (HP:0100587)	2.18899025
48	Recurrent bacterial skin infections (HP:0005406)	2.18622201
49	Eosinophilia (HP:0001880)	2.17639686
50	Loss of speech (HP:0002371)	2.15795315
51	Anorexia (HP:0002039)	2.13113160
52	Panhypogammaglobulinemia (HP:0003139)	2.12300012
53	Aplasia cutis congenita (HP:0001057)	2.10550762
54	Abnormal protein glycosylation (HP:0012346)	2.09582013
55	Abnormal glycosylation (HP:0012345)	2.09582013
56	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.09582013
57	Abnormal protein N-linked glycosylation (HP:0012347)	2.09582013
58	Ragged-red muscle fibers (HP:0003200)	2.08249234
59	Leukopenia (HP:0001882)	2.06914975
60	Esophageal varix (HP:0002040)	2.04755520
61	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.04566817
62	Hypoplasia of the uterus (HP:0000013)	2.03433582
63	Gastrointestinal inflammation (HP:0004386)	2.01329688
64	Inflammation of the large intestine (HP:0002037)	2.01314885
65	Bone marrow hypocellularity (HP:0005528)	1.99261819
66	Abnormality of the ileum (HP:0001549)	1.98676741
67	Septate vagina (HP:0001153)	1.97286504
68	Meckel diverticulum (HP:0002245)	1.96939068
69	Squamous cell carcinoma (HP:0002860)	1.96406817
70	Sex reversal (HP:0012245)	1.95931483
71	Abnormal sex determination (HP:0012244)	1.95931483
72	Abnormality of T cells (HP:0002843)	1.94486347
73	Abnormality of eosinophils (HP:0001879)	1.94088368
74	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.93287765
75	Absent thumb (HP:0009777)	1.93188568
76	Spontaneous hematomas (HP:0007420)	1.92133660
77	Abnormality of chromosome stability (HP:0003220)	1.91402206
78	Hypertensive crisis (HP:0100735)	1.90684946
79	Increased cerebral lipofuscin (HP:0011813)	1.90181144
80	Abnormality of B cell number (HP:0010975)	1.89720715
81	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.88513538
82	Agammaglobulinemia (HP:0004432)	1.88357760
83	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.86779867
84	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.86732545
85	Amaurosis fugax (HP:0100576)	1.86480174
86	Aplasia/hypoplasia of the uterus (HP:0008684)	1.86384477
87	Birth length less than 3rd percentile (HP:0003561)	1.85228179
88	Arteriovenous malformation (HP:0100026)	1.84941624
89	Abnormality of T cell physiology (HP:0011840)	1.84166227
90	Acute lymphatic leukemia (HP:0006721)	1.83132376
91	Thoracolumbar scoliosis (HP:0002944)	1.82294606
92	Cellulitis (HP:0100658)	1.81598084
93	Recurrent fungal infections (HP:0002841)	1.81597028
94	Meningitis (HP:0001287)	1.81576142
95	Prostate neoplasm (HP:0100787)	1.81052721
96	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.81032624
97	Lymphoma (HP:0002665)	1.80766915
98	Conjunctival telangiectasia (HP:0000524)	1.80466960
99	T lymphocytopenia (HP:0005403)	1.79022072
100	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.78972403

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.16515133
2	VRK2	3.30058559
3	SMG1	3.10389235
4	MARK3	3.06625720
5	IRAK3	2.99622613
6	PINK1	2.55386533
7	MAP4K1	2.51103664
8	EIF2AK3	2.33839971
9	ZAK	2.08342280
10	MAP3K10	2.06840091
11	VRK1	1.94742696
12	TAF1	1.92235289
13	TLK1	1.83664790
14	CDC7	1.81920007
15	RPS6KB2	1.81656274
16	MAP3K3	1.72926056
17	BUB1	1.53159678
18	IKBKB	1.50159795
19	PRPF4B	1.48761818
20	MAP3K14	1.48139087
21	NEK2	1.43333141
22	FGR	1.42481150
23	CDK12	1.42215004
24	CDK9	1.39113073
25	TBK1	1.36222493
26	CDK7	1.34707551
27	MAP2K3	1.33605650
28	TESK2	1.25291173
29	JAK3	1.18889548
30	PBK	1.18185121
31	STK10	1.16449841
32	AURKA	1.16203242
33	TRIB3	1.14858687
34	NEK1	1.09660151
35	TAOK2	1.07184987
36	MELK	1.01711948
37	MAP3K8	1.01018141
38	MAP3K13	1.00406633
39	NLK	0.97774738
40	IKBKE	0.97530398
41	PIM1	0.96980640
42	DYRK3	0.96344477
43	PIM2	0.94500606
44	PLK4	0.94316868
45	PAK4	0.93739490
46	CDK4	0.93278804
47	RPS6KA5	0.91598541
48	MAP3K1	0.91076940
49	CCNB1	0.90955218
50	STK4	0.87674490
51	IRAK2	0.86905942
52	WEE1	0.84564839
53	CSNK1G3	0.83232253
54	TSSK6	0.82127721
55	RPS6KA4	0.81739574
56	NUAK1	0.80421094
57	CSNK1G1	0.79411787
58	CSNK1A1L	0.79174463
59	ACVR1B	0.79145239
60	EIF2AK1	0.78153938
61	PASK	0.76124985
62	DAPK3	0.74999507
63	IRAK4	0.72494928
64	CDK8	0.71394443
65	GRK6	0.71376198
66	BTK	0.69267653
67	SRPK1	0.67285314
68	MST4	0.67095827
69	PAK1	0.66453606
70	TESK1	0.64973890
71	MUSK	0.64080983
72	AURKB	0.63879783
73	CDK3	0.63477195
74	MAP3K11	0.62662670
75	PRKCQ	0.61762373
76	BRAF	0.61456230
77	SIK3	0.59480007
78	EEF2K	0.57012365
79	ATR	0.56506508
80	CHEK2	0.56188889
81	RPS6KA1	0.55849899
82	CHEK1	0.55075274
83	PLK1	0.54256961
84	HIPK2	0.53780540
85	MAP3K9	0.52690370
86	MAPK11	0.52308027
87	DAPK1	0.52048096
88	MAPKAPK2	0.51505497
89	TAOK1	0.51384623
90	TTK	0.50919322
91	TYK2	0.50450516
92	SCYL2	0.50308030
93	RPS6KB1	0.50211254
94	PRKG2	0.49388175
95	EIF2AK2	0.46583611
96	BRSK2	0.46223840
97	ARAF	0.45670202
98	MTOR	0.44850316
99	ERN1	0.44680016
100	MATK	0.42774909

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.44497007
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.11686224
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.82730936
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.43795640
5	Proteasome_Homo sapiens_hsa03050	2.35895399
6	NF-kappa B signaling pathway_Homo sapiens_hsa04064	2.12393505
7	Mismatch repair_Homo sapiens_hsa03430	2.04849155
8	Base excision repair_Homo sapiens_hsa03410	1.99626005
9	Spliceosome_Homo sapiens_hsa03040	1.89466361
10	Herpes simplex infection_Homo sapiens_hsa05168	1.87216941
11	RNA transport_Homo sapiens_hsa03013	1.84393826
12	Allograft rejection_Homo sapiens_hsa05330	1.76398235
13	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.70305897
14	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.66523577
15	Apoptosis_Homo sapiens_hsa04210	1.66236670
16	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	1.64596472
17	One carbon pool by folate_Homo sapiens_hsa00670	1.64456649
18	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.62114300
19	Alcoholism_Homo sapiens_hsa05034	1.58367347
20	Viral carcinogenesis_Homo sapiens_hsa05203	1.58293165
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55027708
22	Antigen processing and presentation_Homo sapiens_hsa04612	1.53894958
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.51109605
24	Graft-versus-host disease_Homo sapiens_hsa05332	1.48639938
25	Other glycan degradation_Homo sapiens_hsa00511	1.48262098
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.43509819
27	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.41660060
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.41427503
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.41205795
30	mRNA surveillance pathway_Homo sapiens_hsa03015	1.40547673
31	Selenocompound metabolism_Homo sapiens_hsa00450	1.39933374
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.34556605
33	Legionellosis_Homo sapiens_hsa05134	1.32774798
34	Type I diabetes mellitus_Homo sapiens_hsa04940	1.32238522
35	Measles_Homo sapiens_hsa05162	1.31730347
36	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.30013369
37	Acute myeloid leukemia_Homo sapiens_hsa05221	1.28543858
38	Cell cycle_Homo sapiens_hsa04110	1.27305688
39	RNA degradation_Homo sapiens_hsa03018	1.25414551
40	Sulfur relay system_Homo sapiens_hsa04122	1.20110195
41	RNA polymerase_Homo sapiens_hsa03020	1.19583485
42	Hepatitis B_Homo sapiens_hsa05161	1.17771540
43	Homologous recombination_Homo sapiens_hsa03440	1.17150462
44	Influenza A_Homo sapiens_hsa05164	1.14438617
45	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.07510268
46	Osteoclast differentiation_Homo sapiens_hsa04380	1.06591587
47	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.05165985
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.04024158
49	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.01694573
50	Asthma_Homo sapiens_hsa05310	1.01011781
51	Basal transcription factors_Homo sapiens_hsa03022	1.00483672
52	TNF signaling pathway_Homo sapiens_hsa04668	0.98638270
53	Thyroid cancer_Homo sapiens_hsa05216	0.97505956
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.96146095
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.95628969
56	Viral myocarditis_Homo sapiens_hsa05416	0.95176036
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93857658
58	Lysosome_Homo sapiens_hsa04142	0.89691574
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.89657582
60	Pentose phosphate pathway_Homo sapiens_hsa00030	0.89337556
61	Leishmaniasis_Homo sapiens_hsa05140	0.88491470
62	Galactose metabolism_Homo sapiens_hsa00052	0.86606489
63	HTLV-I infection_Homo sapiens_hsa05166	0.85529976
64	p53 signaling pathway_Homo sapiens_hsa04115	0.79164108
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78469842
66	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.77962971
67	Tuberculosis_Homo sapiens_hsa05152	0.76753371
68	Purine metabolism_Homo sapiens_hsa00230	0.74695415
69	Prostate cancer_Homo sapiens_hsa05215	0.74076949
70	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.71886858
71	Folate biosynthesis_Homo sapiens_hsa00790	0.71825648
72	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.69977350
73	Bladder cancer_Homo sapiens_hsa05219	0.68972424
74	Shigellosis_Homo sapiens_hsa05131	0.68728375
75	Phagosome_Homo sapiens_hsa04145	0.67349211
76	Hepatitis C_Homo sapiens_hsa05160	0.65980221
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.64737381
78	Toxoplasmosis_Homo sapiens_hsa05145	0.62111420
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.61910911
80	Non-small cell lung cancer_Homo sapiens_hsa05223	0.60327135
81	Glutathione metabolism_Homo sapiens_hsa00480	0.58692066
82	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.55642088
83	Endometrial cancer_Homo sapiens_hsa05213	0.54766317
84	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.52815606
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.51477643
86	Ribosome_Homo sapiens_hsa03010	0.50186135
87	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.49305400
88	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.48521853
89	Oocyte meiosis_Homo sapiens_hsa04114	0.48504342
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.46364815
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.44348707
92	Carbon metabolism_Homo sapiens_hsa01200	0.42733481
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42178501
94	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.39031373
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37583738
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37532499
97	Sulfur metabolism_Homo sapiens_hsa00920	0.36684207
98	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.36349399
99	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.35868171
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.34181975

C14ORF169

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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