ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	low-density lipoprotein particle clearance (GO:0034383)	9.08384485
2	regulation of sequestering of triglyceride (GO:0010889)	8.45952442
3	triglyceride catabolic process (GO:0019433)	7.79151627
4	fatty acid homeostasis (GO:0055089)	7.03308306
5	acylglycerol catabolic process (GO:0046464)	6.94079998
6	neutral lipid catabolic process (GO:0046461)	6.94079998
7	NADH metabolic process (GO:0006734)	6.33939845
8	fatty acid transmembrane transport (GO:1902001)	5.29752082
9	diacylglycerol metabolic process (GO:0046339)	5.28255720
10	glycerolipid catabolic process (GO:0046503)	5.07105933
11	brown fat cell differentiation (GO:0050873)	5.06993516
12	cellular response to epinephrine stimulus (GO:0071872)	5.06645668
13	carnitine shuttle (GO:0006853)	4.91147320
14	lipid particle organization (GO:0034389)	4.90556010
15	triglyceride biosynthetic process (GO:0019432)	4.83747264
16	biotin metabolic process (GO:0006768)	4.73069709
17	neutral lipid biosynthetic process (GO:0046460)	4.62424879
18	acylglycerol biosynthetic process (GO:0046463)	4.62424879
19	lipid storage (GO:0019915)	4.59945432
20	regulation of cholesterol storage (GO:0010885)	4.54436010
21	positive regulation of lipid storage (GO:0010884)	4.53998590
22	response to epinephrine (GO:0071871)	4.43987105
23	ethanol oxidation (GO:0006069)	4.39066745
24	oxaloacetate metabolic process (GO:0006107)	4.26278832
25	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	4.19701295
26	white fat cell differentiation (GO:0050872)	4.18532195
27	plasma lipoprotein particle clearance (GO:0034381)	4.17061040
28	cardiac myofibril assembly (GO:0055003)	4.11796316
29	acyl-CoA biosynthetic process (GO:0071616)	4.10207355
30	thioester biosynthetic process (GO:0035384)	4.10207355
31	detection of calcium ion (GO:0005513)	4.06520360
32	regulation of glycogen (starch) synthase activity (GO:2000465)	4.04055296
33	cardiac muscle contraction (GO:0060048)	4.01435582
34	alpha-linolenic acid metabolic process (GO:0036109)	3.99464886
35	phospholipid homeostasis (GO:0055091)	3.98143098
36	triglyceride metabolic process (GO:0006641)	3.96986139
37	tricarboxylic acid metabolic process (GO:0072350)	3.93489327
38	sarcomere organization (GO:0045214)	3.93246811
39	CDP-diacylglycerol biosynthetic process (GO:0016024)	3.90005735
40	protein heterotrimerization (GO:0070208)	3.89089541
41	muscle filament sliding (GO:0030049)	3.85143413
42	actin-myosin filament sliding (GO:0033275)	3.85143413
43	regulation of cAMP-dependent protein kinase activity (GO:2000479)	3.84769391
44	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.74425176
45	CDP-diacylglycerol metabolic process (GO:0046341)	3.73569692
46	fatty-acyl-CoA metabolic process (GO:0035337)	3.71610743
47	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.70983801
48	acylglycerol metabolic process (GO:0006639)	3.69533630
49	myofibril assembly (GO:0030239)	3.68383988
50	acetyl-CoA metabolic process (GO:0006084)	3.66747672
51	neutral lipid metabolic process (GO:0006638)	3.64125449
52	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.62850442
53	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.60486093
54	polyol transport (GO:0015791)	3.59795082
55	potassium ion export (GO:0071435)	3.58596700
56	transcytosis (GO:0045056)	3.58181942
57	carnitine transmembrane transport (GO:1902603)	3.57962312
58	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.56473573
59	thioester metabolic process (GO:0035383)	3.51410129
60	acyl-CoA metabolic process (GO:0006637)	3.51410129
61	response to dietary excess (GO:0002021)	3.46147742
62	negative regulation of granulocyte differentiation (GO:0030853)	3.41839694
63	positive regulation of glomerulus development (GO:0090193)	3.41642071
64	cGMP-mediated signaling (GO:0019934)	3.41425371
65	ethanol metabolic process (GO:0006067)	3.37221701
66	phosphatidic acid biosynthetic process (GO:0006654)	3.36892968
67	phosphatidic acid metabolic process (GO:0046473)	3.36892968
68	positive regulation of cholesterol efflux (GO:0010875)	3.36843440
69	fatty acid beta-oxidation (GO:0006635)	3.32625256
70	regulation of cell communication by electrical coupling (GO:0010649)	3.32447307
71	creatine metabolic process (GO:0006600)	3.29837561
72	regulation of actin filament-based movement (GO:1903115)	3.29439826
73	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	3.28710975
74	long-chain fatty-acyl-CoA metabolic process (GO:0035336)	3.25858706
75	primary alcohol metabolic process (GO:0034308)	3.25819191
76	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	3.25544530
77	regulation of fatty acid oxidation (GO:0046320)	3.25403204
78	carnitine transport (GO:0015879)	3.24800677
79	amino-acid betaine transport (GO:0015838)	3.24800677
80	regulation of lipid storage (GO:0010883)	3.23704549
81	actin-mediated cell contraction (GO:0070252)	3.20120512
82	regulation of macrophage derived foam cell differentiation (GO:0010743)	3.19619703
83	regulation of lipoprotein metabolic process (GO:0050746)	3.18780978
84	glycerol metabolic process (GO:0006071)	3.17276845
85	regulation of the force of heart contraction (GO:0002026)	3.17164854
86	cardiac muscle hypertrophy (GO:0003300)	3.15235034
87	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	3.13724135
88	heart process (GO:0003015)	3.12710933
89	heart contraction (GO:0060047)	3.12710933
90	activation of protein kinase A activity (GO:0034199)	3.12668933
91	striated muscle hypertrophy (GO:0014897)	3.08961919
92	regulation of triglyceride biosynthetic process (GO:0010866)	3.08878741
93	response to phenylpropanoid (GO:0080184)	3.08453154
94	long-chain fatty acid transport (GO:0015909)	3.08010424
95	cellular response to monoamine stimulus (GO:0071868)	3.07738441
96	cellular response to catecholamine stimulus (GO:0071870)	3.07738441
97	valine metabolic process (GO:0006573)	3.07711038
98	positive regulation of fatty acid metabolic process (GO:0045923)	3.07377731
99	negative regulation of macrophage differentiation (GO:0045650)	3.03548177
100	retina vasculature morphogenesis in camera-type eye (GO:0061299)	3.02846136

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	5.28034229
2	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.63976129
3	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.28797256
4	CLOCK_20551151_ChIP-Seq_293T_Human	3.27880010
5	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.10241641
6	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.88604059
7	TBX20_22328084_ChIP-Seq_HEART_Mouse	2.64600786
8	TBX20_22080862_ChIP-Seq_HEART_Mouse	2.64600786
9	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.54602899
10	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.39307564
11	LXR_22158963_ChIP-Seq_LIVER_Mouse	2.30276576
12	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.29097160
13	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	2.18359976
14	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	10.9177092
15	EZH2_22144423_ChIP-Seq_EOC_Human	1.99379852
16	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.94701953
17	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.81449338
18	GATA1_22025678_ChIP-Seq_K562_Human	1.76844670
19	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.68224199
20	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.67137321
21	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.65607074
22	ZNF263_19887448_ChIP-Seq_K562_Human	1.64528643
23	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.59601755
24	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.57798430
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.54371650
26	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54102080
27	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.50848881
28	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	1.46331644
29	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.44127307
30	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.42708663
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.37403116
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.33036047
33	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.33036047
34	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.32690774
35	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.29940152
36	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.27864987
37	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.26914447
38	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.25761865
39	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.22944402
40	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.21578853
41	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.21413814
42	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.20657975
43	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.19049714
44	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.18545871
45	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.18362663
46	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.13928048
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12594475
48	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.11575401
49	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.11529611
50	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.10866680
51	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.07963617
52	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.06291158
53	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.05706179
54	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.05626276
55	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.04829613
56	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.04732084
57	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.03162317
58	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.01662072
59	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.00966340
60	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.97830547
61	* CTCF_27219007_Chip-Seq_Bcells_Human	0.96812632
62	SA1_22415368_ChIP-Seq_MEFs_Mouse	0.90513385
63	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.89314812
64	LXR_22292898_ChIP-Seq_THP-1_Human	0.87414828
65	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.87289020
66	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.87070560
67	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.86854861
68	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.86365683
69	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.85503811
70	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.85256136
71	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.84857981
72	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.84033673
73	SMC4_20622854_ChIP-Seq_HELA_Human	0.83744370
74	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.83646009
75	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.82838709
76	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.81818462
77	CJUN_26792858_Chip-Seq_BT549_Human	0.80718327
78	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.80646806
79	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.79621624
80	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.79026946
81	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.78649358
82	KDM2B_26808549_Chip-Seq_K562_Human	0.78048468
83	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.77917898
84	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.75142248
85	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.74790939
86	* DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.73731735
87	* CBP_21632823_ChIP-Seq_H3396_Human	0.72366182
88	RACK7_27058665_Chip-Seq_MCF-7_Human	0.71377589
89	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.71257979
90	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.70382004
91	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.69735505
92	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.69530848
93	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.68948637
94	KDM2B_26808549_Chip-Seq_DND41_Human	0.68813375
95	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.68504735
96	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.68121398
97	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.67504142
98	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.66919526
99	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.65616150
100	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.65596483

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005670_abnormal_white_adipose	7.31030270
2	MP0005666_abnormal_adipose_tissue	4.91151166
3	MP0004130_abnormal_muscle_cell	4.73363296
4	MP0002971_abnormal_brown_adipose	3.78951490
5	MP0004084_abnormal_cardiac_muscle	3.71452500
6	MP0000751_myopathy	3.71352393
7	MP0005375_adipose_tissue_phenotype	3.47369058
8	MP0004185_abnormal_adipocyte_glucose	3.40144351
9	MP0006138_congestive_heart_failure	3.05172651
10	MP0004215_abnormal_myocardial_fiber	2.95167972
11	MP0002837_dystrophic_cardiac_calcinosis	2.91567147
12	MP0004036_abnormal_muscle_relaxation	2.58218915
13	MP0009115_abnormal_fat_cell	2.44085526
14	MP0003828_pulmonary_edema	2.35256032
15	MP0005385_cardiovascular_system_phenoty	2.25012452
16	MP0001544_abnormal_cardiovascular_syste	2.25012452
17	MP0002972_abnormal_cardiac_muscle	2.19673311
18	MP0005330_cardiomyopathy	2.16358554
19	MP0005334_abnormal_fat_pad	2.11346420
20	MP0000749_muscle_degeneration	2.05282872
21	MP0002970_abnormal_white_adipose	2.04712982
22	MP0004087_abnormal_muscle_fiber	2.04675640
23	MP0005535_abnormal_body_temperature	2.01818606
24	MP0010329_abnormal_lipoprotein_level	2.01038015
25	MP0008775_abnormal_heart_ventricle	2.00730288
26	MP0000003_abnormal_adipose_tissue	1.93879304
27	MP0003137_abnormal_impulse_conducting	1.88252767
28	MP0003959_abnormal_lean_body	1.82078881
29	MP0005620_abnormal_muscle_contractility	1.72148661
30	MP0003646_muscle_fatigue	1.70952564
31	MP0010630_abnormal_cardiac_muscle	1.61744439
32	MP0004484_altered_response_of	1.61109673
33	MP0002118_abnormal_lipid_homeostasis	1.59104942
34	MP0000343_altered_response_to	1.56918931
35	MP0005448_abnormal_energy_balance	1.56100990
36	MP0003011_delayed_dark_adaptation	1.55487332
37	MP0006036_abnormal_mitochondrial_physio	1.53940280
38	MP0008438_abnormal_cutaneous_collagen	1.51057122
39	MP0005503_abnormal_tendon_morphology	1.49528519
40	MP0000759_abnormal_skeletal_muscle	1.45551797
41	MP0001661_extended_life_span	1.38069259
42	MP0003186_abnormal_redox_activity	1.37353750
43	MP0002876_abnormal_thyroid_physiology	1.31793219
44	MP0000013_abnormal_adipose_tissue	1.31031443
45	MP0005452_abnormal_adipose_tissue	1.29144062
46	MP0005275_abnormal_skin_tensile	1.28347258
47	MP0003724_increased_susceptibility_to	1.25232709
48	MP0003279_aneurysm	1.21554357
49	MP0002108_abnormal_muscle_morphology	1.20674241
50	MP0004510_myositis	1.19350577
51	MP0003868_abnormal_feces_composition	1.17176422
52	MP0004085_abnormal_heartbeat	1.16365906
53	MP0002078_abnormal_glucose_homeostasis	1.14590546
54	MP0002106_abnormal_muscle_physiology	1.14246696
55	MP0002269_muscular_atrophy	1.13665555
56	MP0005165_increased_susceptibility_to	1.11785995
57	MP0004272_abnormal_basement_membrane	1.11370807
58	MP0005369_muscle_phenotype	1.11119026
59	MP0010368_abnormal_lymphatic_system	1.10118907
60	MP0002638_abnormal_pupillary_reflex	1.08876278
61	MP0003690_abnormal_glial_cell	1.07655980
62	MP0002127_abnormal_cardiovascular_syste	1.06726172
63	MP0000750_abnormal_muscle_regeneration	1.02558511
64	MP0003705_abnormal_hypodermis_morpholog	0.98773762
65	MP0003950_abnormal_plasma_membrane	0.97363354
66	MP0005584_abnormal_enzyme/coenzyme_acti	0.97061985
67	MP0000747_muscle_weakness	0.96424367
68	MP0009840_abnormal_foam_cell	0.96340807
69	MP0009780_abnormal_chondrocyte_physiolo	0.94524078
70	MP0003191_abnormal_cellular_cholesterol	0.93868988
71	MP0005167_abnormal_blood-brain_barrier	0.91256426
72	MP0003948_abnormal_gas_homeostasis	0.87908258
73	MP0002295_abnormal_pulmonary_circulatio	0.87555858
74	MP0005595_abnormal_vascular_smooth	0.85787280
75	MP0003221_abnormal_cardiomyocyte_apopto	0.82926328
76	MP0000767_abnormal_smooth_muscle	0.81366951
77	MP0001879_abnormal_lymphatic_vessel	0.78866036
78	MP0002332_abnormal_exercise_endurance	0.76251504
79	MP0005266_abnormal_metabolism	0.74985670
80	MP0000249_abnormal_blood_vessel	0.72339517
81	MP0001958_emphysema	0.69631659
82	MP0002909_abnormal_adrenal_gland	0.69462537
83	MP0000609_abnormal_liver_physiology	0.66711871
84	MP0000230_abnormal_systemic_arterial	0.65056610
85	MP0004145_abnormal_muscle_electrophysio	0.63478783
86	MP0005647_abnormal_sex_gland	0.63023828
87	MP0003953_abnormal_hormone_level	0.61733157
88	MP0000266_abnormal_heart_morphology	0.60932982
89	MP0005164_abnormal_response_to	0.57939958
90	MP0002128_abnormal_blood_circulation	0.57702352
91	MP0002933_joint_inflammation	0.56785186
92	MP0001727_abnormal_embryo_implantation	0.54541092
93	MP0001881_abnormal_mammary_gland	0.54260845
94	MP0002139_abnormal_hepatobiliary_system	0.53653704
95	MP0005332_abnormal_amino_acid	0.53305275
96	MP0005388_respiratory_system_phenotype	0.52443843
97	MP0002133_abnormal_respiratory_system	0.52443843
98	MP0005379_endocrine/exocrine_gland_phen	0.46544108
99	MP0009672_abnormal_birth_weight	0.42179428
100	MP0005365_abnormal_bile_salt	0.42125535

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sudden death (HP:0001699)	6.27100691
2	Oligomenorrhea (HP:0000876)	5.42613145
3	Lipoatrophy (HP:0100578)	5.30562493
4	Hyporeflexia of lower limbs (HP:0002600)	5.21885017
5	Increased variability in muscle fiber diameter (HP:0003557)	4.88164195
6	Bundle branch block (HP:0011710)	4.85027804
7	Hypertriglyceridemia (HP:0002155)	4.79408522
8	Muscle fiber splitting (HP:0003555)	4.74250825
9	Atrial fibrillation (HP:0005110)	4.71785036
10	Ventricular tachycardia (HP:0004756)	4.63193940
11	Acanthosis nigricans (HP:0000956)	4.59783815
12	Difficulty running (HP:0009046)	4.45384763
13	Asymmetric septal hypertrophy (HP:0001670)	4.33787553
14	Primary atrial arrhythmia (HP:0001692)	4.28804648
15	Abnormality of skeletal muscle fiber size (HP:0012084)	4.26397194
16	Dilated cardiomyopathy (HP:0001644)	4.15722301
17	Supraventricular tachycardia (HP:0004755)	4.14898694
18	Supraventricular arrhythmia (HP:0005115)	4.10807020
19	Myoglobinuria (HP:0002913)	3.93128166
20	Rhabdomyolysis (HP:0003201)	3.91899466
21	Syncope (HP:0001279)	3.68797119
22	Atrioventricular block (HP:0001678)	3.63382771
23	Heart block (HP:0012722)	3.57101305
24	Neck muscle weakness (HP:0000467)	3.56260741
25	Abnormality of the calf musculature (HP:0001430)	3.55029510
26	Right ventricular cardiomyopathy (HP:0011663)	3.50989656
27	Distal lower limb muscle weakness (HP:0009053)	3.50146517
28	Exercise-induced myalgia (HP:0003738)	3.48930635
29	Abnormal atrioventricular conduction (HP:0005150)	3.48800071
30	Increased serum pyruvate (HP:0003542)	3.48438532
31	EMG: myopathic abnormalities (HP:0003458)	3.37331496
32	Increased connective tissue (HP:0009025)	3.35012811
33	Increased muscle lipid content (HP:0009058)	3.22654184
34	Hyperlipoproteinemia (HP:0010980)	3.20021876
35	Nausea (HP:0002018)	3.17670482
36	Ventricular arrhythmia (HP:0004308)	3.14670774
37	Skin nodule (HP:0200036)	3.13496276
38	Abnormality of glycolysis (HP:0004366)	3.11683743
39	Type 1 muscle fiber predominance (HP:0003803)	3.06117827
40	Subaortic stenosis (HP:0001682)	3.05266410
41	Abnormality of the left ventricular outflow tract (HP:0011103)	3.05266410
42	Protrusio acetabuli (HP:0003179)	2.99000452
43	Insulin resistance (HP:0000855)	2.98497770
44	Insulin-resistant diabetes mellitus (HP:0000831)	2.94457779
45	Abnormality of fatty-acid metabolism (HP:0004359)	2.86219009
46	Prolonged QT interval (HP:0001657)	2.80691958
47	Ragged-red muscle fibers (HP:0003200)	2.78618362
48	Abnormality of the foot musculature (HP:0001436)	2.74501981
49	Rimmed vacuoles (HP:0003805)	2.73641824
50	EMG: neuropathic changes (HP:0003445)	2.66713714
51	Myocardial infarction (HP:0001658)	2.64209368
52	Palpitations (HP:0001962)	2.64131416
53	Calf muscle hypertrophy (HP:0008981)	2.63733356
54	Complement deficiency (HP:0004431)	2.57288161
55	Frequent falls (HP:0002359)	2.54522767
56	Foot dorsiflexor weakness (HP:0009027)	2.54209843
57	Scapular winging (HP:0003691)	2.53674066
58	Epidermoid cyst (HP:0200040)	2.49827946
59	Hypercortisolism (HP:0001578)	2.44895777
60	Growth hormone excess (HP:0000845)	2.43020668
61	Spinal rigidity (HP:0003306)	2.42608424
62	Hypoglycemic coma (HP:0001325)	2.41164221
63	Muscle hypertrophy of the lower extremities (HP:0008968)	2.40560356
64	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.40366082
65	Axonal loss (HP:0003447)	2.38864739
66	Ventricular fibrillation (HP:0001663)	2.33260050
67	Abnormal EKG (HP:0003115)	2.31347443
68	Hemorrhage of the eye (HP:0011885)	2.28782023
69	Bone cyst (HP:0012062)	2.25519932
70	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.24809821
71	Gowers sign (HP:0003391)	2.24332867
72	Xanthomatosis (HP:0000991)	2.24321827
73	Long foot (HP:0001833)	2.19833510
74	Lymphangioma (HP:0100764)	2.19571384
75	Pigmentary retinal degeneration (HP:0001146)	2.16978497
76	Mildly elevated creatine phosphokinase (HP:0008180)	2.16936233
77	Infantile muscular hypotonia (HP:0008947)	2.16591152
78	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.15558491
79	Dicarboxylic aciduria (HP:0003215)	2.15558491
80	Hypercholesterolemia (HP:0003124)	2.13440477
81	Back pain (HP:0003418)	2.12390928
82	Aortic aneurysm (HP:0004942)	2.12257728
83	Bradycardia (HP:0001662)	2.11361510
84	Polycythemia (HP:0001901)	2.07216647
85	Abnormality of complement system (HP:0005339)	2.03992421
86	Resting tremor (HP:0002322)	2.03647545
87	Abnormality of alanine metabolism (HP:0010916)	2.03315486
88	Hyperalaninemia (HP:0003348)	2.03315486
89	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03315486
90	Reduced subcutaneous adipose tissue (HP:0003758)	2.00250770
91	Pulmonary artery stenosis (HP:0004415)	1.99864105
92	Prominent supraorbital ridges (HP:0000336)	1.98674807
93	Bulbar palsy (HP:0001283)	1.98532030
94	Generalized muscle weakness (HP:0003324)	1.95847174
95	Vertebral compression fractures (HP:0002953)	1.94149967
96	Distal lower limb amyotrophy (HP:0008944)	1.92038137
97	Sudden cardiac death (HP:0001645)	1.90178474
98	Areflexia of lower limbs (HP:0002522)	1.87105633
99	Steppage gait (HP:0003376)	1.84473884
100	Myotonia (HP:0002486)	1.82922662

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MYLK	5.95539213
2	TTN	4.37153613
3	TRIB3	3.37252688
4	PRKAA2	2.63962847
5	TIE1	2.54711526
6	EPHB2	2.53347267
7	RIPK1	2.37416637
8	TGFBR2	2.24566984
9	CAMK1	2.23791735
10	OBSCN	2.23195524
11	SIK1	2.21374856
12	PINK1	2.17600580
13	DMPK	2.12264171
14	MAP3K6	1.92651564
15	DDR2	1.86409603
16	NEK9	1.76159020
17	MAPK12	1.70316304
18	LATS2	1.69093260
19	CAMK1D	1.57541992
20	TESK1	1.56239131
21	MAPK4	1.53424890
22	PRKAA1	1.50561075
23	MAPKAPK3	1.45725540
24	CDC42BPA	1.42443150
25	PDK2	1.40747376
26	PKN2	1.40384146
27	PRKD1	1.30010066
28	TRPM7	1.25573415
29	MUSK	1.24904156
30	DAPK3	1.22700701
31	PAK3	1.21323372
32	ERN1	1.21077457
33	MAP2K1	1.13665867
34	ABL2	1.11955332
35	EEF2K	1.00880787
36	PDPK1	1.00840916
37	PDGFRA	0.99916714
38	EPHA3	0.99130867
39	ARAF	0.97261420
40	PRKACG	0.97042426
41	PIK3CA	0.96860101
42	CDK6	0.95918236
43	LATS1	0.95067668
44	PHKG2	0.93886580
45	PHKG1	0.93886580
46	MAP3K5	0.91920452
47	CAMK1G	0.91183386
48	ROCK1	0.88307105
49	GRK5	0.85350544
50	EPHB1	0.80835470
51	BCKDK	0.80549770
52	CAMK2D	0.78016542
53	LMTK2	0.74966064
54	STK4	0.74728282
55	MAP3K7	0.74107815
56	PRPF4B	0.71527920
57	STK38L	0.71347798
58	NLK	0.69943013
59	ILK	0.68504893
60	GSK3A	0.66765634
61	PRKG1	0.64514203
62	PKN1	0.63889362
63	CAMK4	0.62151251
64	RPS6KC1	0.61385124
65	RPS6KL1	0.61385124
66	MAP2K3	0.61354513
67	MAPK7	0.60957421
68	PRKCE	0.58619493
69	CAMKK2	0.55711130
70	PAK2	0.54679342
71	PDK1	0.54281992
72	ADRBK1	0.54220604
73	MOS	0.53402069
74	MARK1	0.53304515
75	ROCK2	0.52380348
76	MTOR	0.51383032
77	RPS6KA6	0.50013481
78	CDK4	0.49888099
79	RET	0.49003084
80	PRKACA	0.47736673
81	AKT2	0.46175669
82	CAMK2G	0.45987238
83	PRKACB	0.45899874
84	JAK2	0.45733787
85	ICK	0.44683562
86	IGF1R	0.44284272
87	KSR2	0.44140620
88	RPS6KA3	0.43884779
89	CAMK2A	0.43475041
90	GRK7	0.43429618
91	PIM2	0.42932629
92	MAPK3	0.42350614
93	PDGFRB	0.41998364
94	TBK1	0.41729683
95	CSK	0.39731236
96	STK38	0.39350822
97	MAP3K13	0.37104326
98	ZAP70	0.34813401
99	KDR	0.33541459
100	CDK9	0.33273317

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	PPAR signaling pathway_Homo sapiens_hsa03320	4.42241867
2	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	4.10296566
3	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.75737232
4	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.56477962
5	Pyruvate metabolism_Homo sapiens_hsa00620	3.19039232
6	Phenylalanine metabolism_Homo sapiens_hsa00360	3.13884955
7	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.08326311
8	Propanoate metabolism_Homo sapiens_hsa00640	3.03165983
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.99391183
10	Fatty acid metabolism_Homo sapiens_hsa01212	2.98752449
11	Fatty acid elongation_Homo sapiens_hsa00062	2.94534219
12	Fatty acid degradation_Homo sapiens_hsa00071	2.83470739
13	Glycerolipid metabolism_Homo sapiens_hsa00561	2.75205479
14	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.38708750
15	beta-Alanine metabolism_Homo sapiens_hsa00410	2.00908352
16	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.97634555
17	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.94021788
18	Tyrosine metabolism_Homo sapiens_hsa00350	1.82536563
19	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.74812124
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.66846955
21	AMPK signaling pathway_Homo sapiens_hsa04152	1.62520095
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.60397174
23	Fat digestion and absorption_Homo sapiens_hsa04975	1.54475871
24	Carbon metabolism_Homo sapiens_hsa01200	1.54190392
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.40511623
26	Histidine metabolism_Homo sapiens_hsa00340	1.35666832
27	Sulfur relay system_Homo sapiens_hsa04122	1.19192707
28	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.16063728
29	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.15216869
30	Renin secretion_Homo sapiens_hsa04924	1.12631833
31	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.09445366
32	Insulin signaling pathway_Homo sapiens_hsa04910	1.04135974
33	Arginine biosynthesis_Homo sapiens_hsa00220	0.97911798
34	Butanoate metabolism_Homo sapiens_hsa00650	0.95082571
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.91005338
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89033111
37	Insulin resistance_Homo sapiens_hsa04931	0.85470668
38	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.85345663
39	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.84044641
40	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.81800792
41	ECM-receptor interaction_Homo sapiens_hsa04512	0.81685144
42	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.79369654
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.76993719
44	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.75684218
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.74047165
46	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.70658487
47	Peroxisome_Homo sapiens_hsa04146	0.70255124
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.69985640
49	Glucagon signaling pathway_Homo sapiens_hsa04922	0.64171622
50	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.63220162
51	Focal adhesion_Homo sapiens_hsa04510	0.61592159
52	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.58241411
53	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57129388
54	cAMP signaling pathway_Homo sapiens_hsa04024	0.50717120
55	Sulfur metabolism_Homo sapiens_hsa00920	0.48402581
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47593057
57	Lysine degradation_Homo sapiens_hsa00310	0.46908049
58	Parkinsons disease_Homo sapiens_hsa05012	0.45766298
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.45094013
60	Renin-angiotensin system_Homo sapiens_hsa04614	0.38991496
61	Glutathione metabolism_Homo sapiens_hsa00480	0.36625766
62	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.34669111
63	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.34062914
64	Retinol metabolism_Homo sapiens_hsa00830	0.32283185
65	Malaria_Homo sapiens_hsa05144	0.31943842
66	Circadian rhythm_Homo sapiens_hsa04710	0.31587970
67	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.31137245
68	Bile secretion_Homo sapiens_hsa04976	0.30674412
69	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.29261672
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.28595089
71	Alzheimers disease_Homo sapiens_hsa05010	0.27503120
72	Morphine addiction_Homo sapiens_hsa05032	0.26432321
73	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.25415529
74	Cocaine addiction_Homo sapiens_hsa05030	0.20602536
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.19035741
76	Complement and coagulation cascades_Homo sapiens_hsa04610	0.18133712
77	Folate biosynthesis_Homo sapiens_hsa00790	0.17330751
78	GnRH signaling pathway_Homo sapiens_hsa04912	0.16107542
79	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.15917915
80	Melanogenesis_Homo sapiens_hsa04916	0.15487944
81	Oxidative phosphorylation_Homo sapiens_hsa00190	0.14135887
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.14021561
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.13825834
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.13302295
85	Tight junction_Homo sapiens_hsa04530	0.12955727
86	Gap junction_Homo sapiens_hsa04540	0.12718429
87	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.12625406
88	Gastric acid secretion_Homo sapiens_hsa04971	0.09229007
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.09107006
90	Metabolic pathways_Homo sapiens_hsa01100	0.08839168
91	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.07959949
92	ABC transporters_Homo sapiens_hsa02010	0.07906048
93	Circadian entrainment_Homo sapiens_hsa04713	0.07693908
94	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.07289812
95	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.06884111
96	Amoebiasis_Homo sapiens_hsa05146	0.05908407
97	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.05643173
98	Acute myeloid leukemia_Homo sapiens_hsa05221	0.05616042
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.05199368
100	Platelet activation_Homo sapiens_hsa04611	0.04132457

C14ORF180

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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