ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	6.12835735
2	nucleobase catabolic process (GO:0046113)	4.81887437
3	presynaptic membrane assembly (GO:0097105)	4.36320812
4	limb bud formation (GO:0060174)	4.02881419
5	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.98266933
6	presynaptic membrane organization (GO:0097090)	3.96762852
7	neuron cell-cell adhesion (GO:0007158)	3.89708284
8	cerebral cortex radially oriented cell migration (GO:0021799)	3.73814579
9	postsynaptic membrane organization (GO:0001941)	3.69208409
10	behavioral response to nicotine (GO:0035095)	3.64834200
11	retinal ganglion cell axon guidance (GO:0031290)	3.59646070
12	epithelial cilium movement (GO:0003351)	3.55920603
13	somite development (GO:0061053)	3.45539118
14	axonal fasciculation (GO:0007413)	3.44882304
15	regulation of development, heterochronic (GO:0040034)	3.27877234
16	response to pheromone (GO:0019236)	3.27404879
17	neural tube formation (GO:0001841)	3.26708389
18	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.18432053
19	olfactory bulb development (GO:0021772)	3.17711483
20	regulation of timing of cell differentiation (GO:0048505)	3.17430595
21	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.15221225
22	short-term memory (GO:0007614)	3.14863017
23	protein localization to cilium (GO:0061512)	3.14411460
24	vocalization behavior (GO:0071625)	3.09580101
25	intraciliary transport (GO:0042073)	3.09562132
26	gamma-aminobutyric acid transport (GO:0015812)	3.08915497
27	neuron recognition (GO:0008038)	3.07313064
28	DNA integration (GO:0015074)	3.05758304
29	auditory behavior (GO:0031223)	3.05544753
30	regulation of cilium movement (GO:0003352)	3.03394103
31	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.03179342
32	cell migration in hindbrain (GO:0021535)	2.99637090
33	synapse assembly (GO:0007416)	2.99102261
34	cilium movement (GO:0003341)	2.95445136
35	protein polyglutamylation (GO:0018095)	2.89947266
36	positive regulation of mitochondrial fission (GO:0090141)	2.87337055
37	head development (GO:0060322)	2.86400650
38	cilium or flagellum-dependent cell motility (GO:0001539)	2.86101051
39	transmission of nerve impulse (GO:0019226)	2.85941651
40	central nervous system projection neuron axonogenesis (GO:0021952)	2.85153362
41	retinal cone cell development (GO:0046549)	2.84841109
42	protein localization to synapse (GO:0035418)	2.83985502
43	forebrain neuron differentiation (GO:0021879)	2.82090700
44	cilium morphogenesis (GO:0060271)	2.81378361
45	nonmotile primary cilium assembly (GO:0035058)	2.80056346
46	startle response (GO:0001964)	2.78890862
47	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.77776670
48	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.77533512
49	cilium organization (GO:0044782)	2.76586872
50	C4-dicarboxylate transport (GO:0015740)	2.75247393
51	cilium assembly (GO:0042384)	2.74059686
52	retina layer formation (GO:0010842)	2.73324710
53	mechanosensory behavior (GO:0007638)	2.72597528
54	sympathetic nervous system development (GO:0048485)	2.72344976
55	regulation of feeding behavior (GO:0060259)	2.70170418
56	establishment of mitochondrion localization (GO:0051654)	2.69219732
57	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.67768260
58	spinal cord development (GO:0021510)	2.65994628
59	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.65105477
60	protein neddylation (GO:0045116)	2.64997367
61	ganglion development (GO:0061548)	2.62567860
62	synaptic transmission, glutamatergic (GO:0035249)	2.62057553
63	regulation of collateral sprouting (GO:0048670)	2.61778318
64	cerebral cortex cell migration (GO:0021795)	2.56268663
65	DNA double-strand break processing (GO:0000729)	2.54612617
66	cornea development in camera-type eye (GO:0061303)	2.54087946
67	appendage development (GO:0048736)	2.52367920
68	limb development (GO:0060173)	2.52367920
69	hippocampus development (GO:0021766)	2.51267790
70	spinal cord association neuron differentiation (GO:0021527)	2.50817366
71	central nervous system neuron axonogenesis (GO:0021955)	2.50445790
72	negative regulation of glial cell differentiation (GO:0045686)	2.50270324
73	glutamate receptor signaling pathway (GO:0007215)	2.50113547
74	hindbrain development (GO:0030902)	2.46471573
75	sequestering of actin monomers (GO:0042989)	2.45454288
76	positive regulation of synapse assembly (GO:0051965)	2.44375874
77	axonemal dynein complex assembly (GO:0070286)	2.43816949
78	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.43757623
79	inner ear receptor stereocilium organization (GO:0060122)	2.41922463
80	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.41856444
81	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.41699118
82	neuronal stem cell maintenance (GO:0097150)	2.40873852
83	dendritic spine morphogenesis (GO:0060997)	2.40203297
84	glycosphingolipid biosynthetic process (GO:0006688)	2.39600364
85	negative regulation of axon guidance (GO:1902668)	2.39247381
86	regulation of microtubule-based movement (GO:0060632)	2.38306883
87	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.37479673
88	acrosome reaction (GO:0007340)	2.37100715
89	neuron-neuron synaptic transmission (GO:0007270)	2.36725966
90	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.36271196
91	neurofilament cytoskeleton organization (GO:0060052)	2.35779687
92	dendrite morphogenesis (GO:0048813)	2.35203655
93	regulation of action potential (GO:0098900)	2.33954862
94	adult walking behavior (GO:0007628)	2.33255855
95	reflex (GO:0060004)	2.33171417
96	response to auditory stimulus (GO:0010996)	2.31930873
97	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.30160332
98	synapse organization (GO:0050808)	2.29505588
99	lateral sprouting from an epithelium (GO:0060601)	2.29470463
100	determination of left/right symmetry (GO:0007368)	2.28781852

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.09749654
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.49719577
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.33160951
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.22381071
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.07701824
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.92874544
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69962105
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.61012140
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.57151083
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53030022
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.37605862
12	FUS_26573619_Chip-Seq_HEK293_Human	2.35030803
13	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.31624345
14	VDR_22108803_ChIP-Seq_LS180_Human	2.29279820
15	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.25442725
16	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18832575
17	EWS_26573619_Chip-Seq_HEK293_Human	2.14550393
18	P300_19829295_ChIP-Seq_ESCs_Human	2.12693685
19	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.07865464
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.07711223
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.96697887
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.86907669
23	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.84700409
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.79322219
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75172253
26	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.74047407
27	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.71127320
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.70781091
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.69869829
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.67599609
31	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.64412942
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.62863051
33	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.58699577
34	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.57923397
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57862339
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.56774240
37	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.55019976
38	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.54915760
39	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52550965
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49479154
41	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.49396174
42	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48835962
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47475585
44	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.47475585
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.46694563
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45949698
47	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.42525917
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.38654335
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.37811672
50	* AR_25329375_ChIP-Seq_VCAP_Human	1.37767789
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.37715173
52	* STAT3_23295773_ChIP-Seq_U87_Human	1.37226734
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36912355
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.36912355
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.35804447
56	* ER_23166858_ChIP-Seq_MCF-7_Human	1.32766342
57	* TCF4_23295773_ChIP-Seq_U87_Human	1.30777944
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30759301
59	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28271524
60	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27228542
61	AR_21572438_ChIP-Seq_LNCaP_Human	1.26887634
62	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.25168464
63	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24825179
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.21094757
65	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.19811330
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19546167
67	BCAT_22108803_ChIP-Seq_LS180_Human	1.19388196
68	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.18076887
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.17383313
70	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13305880
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.12661853
72	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11686158
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.09749216
74	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09113296
75	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08920456
76	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08857907
77	TCF4_22108803_ChIP-Seq_LS180_Human	1.08583309
78	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08504139
79	MYC_18940864_ChIP-ChIP_HL60_Human	1.07104863
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06533378
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.05590468
82	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05409554
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05371351
84	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04849992
85	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02799174
86	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.02342908
87	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.02336547
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02311411
89	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.02084520
90	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.01833891
91	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.99482644
92	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99151132
93	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.99000116
94	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98701217
95	TP53_22573176_ChIP-Seq_HFKS_Human	0.98443740
96	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97938103
97	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.97913215
98	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97772819
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97735175
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97735175

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.43432778
2	MP0001529_abnormal_vocalization	2.56937797
3	MP0001984_abnormal_olfaction	2.39118703
4	MP0000778_abnormal_nervous_system	2.38440810
5	MP0003122_maternal_imprinting	2.37982735
6	MP0002653_abnormal_ependyma_morphology	2.37512014
7	MP0005394_taste/olfaction_phenotype	2.28744207
8	MP0005499_abnormal_olfactory_system	2.28744207
9	MP0008789_abnormal_olfactory_epithelium	2.28122487
10	MP0002102_abnormal_ear_morphology	2.24555616
11	MP0006292_abnormal_olfactory_placode	2.15921809
12	MP0006072_abnormal_retinal_apoptosis	2.10547943
13	MP0006276_abnormal_autonomic_nervous	2.05964416
14	MP0004133_heterotaxia	2.03480201
15	MP0004859_abnormal_synaptic_plasticity	1.99342352
16	MP0009046_muscle_twitch	1.97633831
17	MP0002822_catalepsy	1.94216567
18	MP0005423_abnormal_somatic_nervous	1.89858042
19	MP0003121_genomic_imprinting	1.88304713
20	MP0003787_abnormal_imprinting	1.85223592
21	MP0008877_abnormal_DNA_methylation	1.84749667
22	MP0004270_analgesia	1.79444037
23	MP0005253_abnormal_eye_physiology	1.76394429
24	MP0001486_abnormal_startle_reflex	1.72546060
25	MP0002272_abnormal_nervous_system	1.72304852
26	MP0000631_abnormal_neuroendocrine_gland	1.69469039
27	MP0003635_abnormal_synaptic_transmissio	1.69326059
28	MP0002751_abnormal_autonomic_nervous	1.68681308
29	MP0000049_abnormal_middle_ear	1.66512078
30	MP0009745_abnormal_behavioral_response	1.62645874
31	MP0003136_yellow_coat_color	1.59107428
32	MP0001968_abnormal_touch/_nociception	1.59010701
33	MP0002735_abnormal_chemical_nociception	1.57183131
34	MP0002638_abnormal_pupillary_reflex	1.55618670
35	MP0005551_abnormal_eye_electrophysiolog	1.54532809
36	MP0004742_abnormal_vestibular_system	1.51701151
37	MP0002736_abnormal_nociception_after	1.48689270
38	MP0002064_seizures	1.48663536
39	MP0002938_white_spotting	1.47846328
40	MP0002572_abnormal_emotion/affect_behav	1.46775438
41	MP0000566_synostosis	1.46120558
42	MP0005171_absent_coat_pigmentation	1.45427565
43	MP0001293_anophthalmia	1.45405572
44	MP0004142_abnormal_muscle_tone	1.45000327
45	MP0002233_abnormal_nose_morphology	1.44429397
46	MP0002063_abnormal_learning/memory/cond	1.44035707
47	MP0003011_delayed_dark_adaptation	1.42198485
48	MP0002557_abnormal_social/conspecific_i	1.41073012
49	MP0003937_abnormal_limbs/digits/tail_de	1.39492911
50	MP0002184_abnormal_innervation	1.38270577
51	MP0005645_abnormal_hypothalamus_physiol	1.37605063
52	MP0003195_calcinosis	1.35286616
53	MP0002734_abnormal_mechanical_nocicepti	1.33628816
54	MP0003938_abnormal_ear_development	1.33259250
55	MP0000955_abnormal_spinal_cord	1.31666215
56	MP0002067_abnormal_sensory_capabilities	1.30657527
57	MP0002234_abnormal_pharynx_morphology	1.30314168
58	MP0008995_early_reproductive_senescence	1.28476431
59	MP0003890_abnormal_embryonic-extraembry	1.27694510
60	MP0002882_abnormal_neuron_morphology	1.22858811
61	MP0000569_abnormal_digit_pigmentation	1.21804647
62	MP0002752_abnormal_somatic_nervous	1.20452961
63	MP0003137_abnormal_impulse_conducting	1.14391560
64	MP0004811_abnormal_neuron_physiology	1.13505866
65	MP0005646_abnormal_pituitary_gland	1.12891631
66	MP0004924_abnormal_behavior	1.12370454
67	MP0005386_behavior/neurological_phenoty	1.12370454
68	MP0001299_abnormal_eye_distance/	1.11883642
69	MP0004215_abnormal_myocardial_fiber	1.10188731
70	MP0010386_abnormal_urinary_bladder	1.09745547
71	MP0003567_abnormal_fetal_cardiomyocyte	1.07158095
72	MP0005391_vision/eye_phenotype	1.07122007
73	MP0000026_abnormal_inner_ear	1.06805886
74	MP0002152_abnormal_brain_morphology	1.06705433
75	MP0005187_abnormal_penis_morphology	1.04989354
76	MP0003861_abnormal_nervous_system	1.03469386
77	MP0004885_abnormal_endolymph	1.03325262
78	MP0004147_increased_porphyrin_level	1.00311657
79	MP0003119_abnormal_digestive_system	0.96062339
80	MP0001485_abnormal_pinna_reflex	0.95320839
81	MP0003755_abnormal_palate_morphology	0.95191646
82	MP0001970_abnormal_pain_threshold	0.93958968
83	MP0001177_atelectasis	0.91967887
84	MP0005195_abnormal_posterior_eye	0.88181295
85	MP0002837_dystrophic_cardiac_calcinosis	0.87406063
86	MP0001286_abnormal_eye_development	0.86796290
87	MP0000647_abnormal_sebaceous_gland	0.86769776
88	MP0010030_abnormal_orbit_morphology	0.85860716
89	MP0001440_abnormal_grooming_behavior	0.83090559
90	MP0006035_abnormal_mitochondrial_morpho	0.83078988
91	MP0002066_abnormal_motor_capabilities/c	0.82229804
92	MP0001188_hyperpigmentation	0.81427954
93	MP0001905_abnormal_dopamine_level	0.81170836
94	MP0002733_abnormal_thermal_nociception	0.80053613
95	MP0003698_abnormal_male_reproductive	0.79617863
96	MP0001963_abnormal_hearing_physiology	0.78199059
97	MP0003385_abnormal_body_wall	0.74031791
98	MP0002697_abnormal_eye_size	0.71616870
99	MP0000372_irregular_coat_pigmentation	0.71507291
100	MP0004085_abnormal_heartbeat	0.71109830

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	4.01920614
2	Pancreatic fibrosis (HP:0100732)	3.45896524
3	Pancreatic cysts (HP:0001737)	3.45220047
4	Abnormality of the labia minora (HP:0012880)	3.30073678
5	Molar tooth sign on MRI (HP:0002419)	3.26836205
6	Abnormality of midbrain morphology (HP:0002418)	3.26836205
7	Nephronophthisis (HP:0000090)	3.18250418
8	Focal motor seizures (HP:0011153)	3.03738824
9	Medial flaring of the eyebrow (HP:0010747)	3.03451101
10	Chronic hepatic failure (HP:0100626)	3.01731497
11	Gait imbalance (HP:0002141)	2.88039463
12	Febrile seizures (HP:0002373)	2.86150351
13	Congenital primary aphakia (HP:0007707)	2.70883344
14	Genital tract atresia (HP:0001827)	2.65848695
15	Abnormal respiratory motile cilium morphology (HP:0005938)	2.64529074
16	Abnormal respiratory epithelium morphology (HP:0012253)	2.64529074
17	Abnormality of the renal medulla (HP:0100957)	2.61021645
18	Atonic seizures (HP:0010819)	2.58257595
19	Drooling (HP:0002307)	2.58248757
20	Vaginal atresia (HP:0000148)	2.58137852
21	Optic nerve hypoplasia (HP:0000609)	2.53161364
22	Nephrogenic diabetes insipidus (HP:0009806)	2.52621877
23	Polyphagia (HP:0002591)	2.52009686
24	Absent/shortened dynein arms (HP:0200106)	2.50634597
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.50634597
26	Broad-based gait (HP:0002136)	2.45006567
27	Hyperventilation (HP:0002883)	2.43248256
28	Postaxial hand polydactyly (HP:0001162)	2.41688263
29	Septo-optic dysplasia (HP:0100842)	2.38730542
30	Abnormal ciliary motility (HP:0012262)	2.38353178
31	Focal seizures (HP:0007359)	2.37885386
32	Progressive cerebellar ataxia (HP:0002073)	2.37075910
33	Supernumerary spleens (HP:0009799)	2.35042266
34	Anencephaly (HP:0002323)	2.33579982
35	Excessive salivation (HP:0003781)	2.28809664
36	Postaxial foot polydactyly (HP:0001830)	2.27044908
37	Intestinal atresia (HP:0011100)	2.22810072
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.20614376
39	Colon cancer (HP:0003003)	2.20186175
40	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19402557
41	Sclerocornea (HP:0000647)	2.18501423
42	Acute necrotizing encephalopathy (HP:0006965)	2.16380665
43	Cutaneous finger syndactyly (HP:0010554)	2.14641912
44	Lissencephaly (HP:0001339)	2.14273170
45	Pachygyria (HP:0001302)	2.11717120
46	Cystic liver disease (HP:0006706)	2.11576442
47	Occipital encephalocele (HP:0002085)	2.11374290
48	Dialeptic seizures (HP:0011146)	2.09290218
49	Abnormal respiratory motile cilium physiology (HP:0012261)	2.08484349
50	Progressive inability to walk (HP:0002505)	2.08052684
51	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.07573792
52	Myokymia (HP:0002411)	2.07349253
53	Inability to walk (HP:0002540)	2.06461346
54	Limb dystonia (HP:0002451)	2.05395907
55	Oligodactyly (hands) (HP:0001180)	2.04828188
56	Pendular nystagmus (HP:0012043)	2.03786643
57	Male pseudohermaphroditism (HP:0000037)	2.02202572
58	Specific learning disability (HP:0001328)	2.01193171
59	Narrow forehead (HP:0000341)	2.01082801
60	Poor coordination (HP:0002370)	2.01033119
61	Abnormal biliary tract physiology (HP:0012439)	2.00820459
62	Bile duct proliferation (HP:0001408)	2.00820459
63	Amyotrophic lateral sclerosis (HP:0007354)	1.99464222
64	Patellar aplasia (HP:0006443)	1.94599549
65	Anophthalmia (HP:0000528)	1.93707597
66	Renal hypoplasia (HP:0000089)	1.93620294
67	Preaxial hand polydactyly (HP:0001177)	1.93588456
68	Short tibia (HP:0005736)	1.91582951
69	Abnormality of macular pigmentation (HP:0008002)	1.88084039
70	Broad foot (HP:0001769)	1.87588814
71	Progressive macrocephaly (HP:0004481)	1.87257746
72	Split foot (HP:0001839)	1.86590772
73	Abnormality of the renal cortex (HP:0011035)	1.83862707
74	Absent septum pellucidum (HP:0001331)	1.83299551
75	Acute encephalopathy (HP:0006846)	1.83075296
76	Retinal dysplasia (HP:0007973)	1.81663886
77	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81492154
78	Mitochondrial inheritance (HP:0001427)	1.79576070
79	Amblyopia (HP:0000646)	1.79224704
80	Cortical dysplasia (HP:0002539)	1.78636961
81	Aqueductal stenosis (HP:0002410)	1.78312514
82	Aplasia/Hypoplasia of the patella (HP:0006498)	1.78118822
83	Tubulointerstitial nephritis (HP:0001970)	1.74153727
84	Epileptic encephalopathy (HP:0200134)	1.73584736
85	Absence seizures (HP:0002121)	1.73157005
86	Micropenis (HP:0000054)	1.72638161
87	Midline defect of the nose (HP:0004122)	1.72530929
88	Congenital stationary night blindness (HP:0007642)	1.72507541
89	Gaze-evoked nystagmus (HP:0000640)	1.72200843
90	Hepatoblastoma (HP:0002884)	1.71613854
91	Growth hormone deficiency (HP:0000824)	1.70916031
92	Scrotal hypoplasia (HP:0000046)	1.70650444
93	Cutaneous syndactyly (HP:0012725)	1.70597022
94	Type II lissencephaly (HP:0007260)	1.68905091
95	Hemiparesis (HP:0001269)	1.68598583
96	Hypothermia (HP:0002045)	1.68431728
97	Vitreoretinal degeneration (HP:0000655)	1.68207137
98	Hyperglycinemia (HP:0002154)	1.66914855
99	Abolished electroretinogram (ERG) (HP:0000550)	1.65941441
100	Exotropia (HP:0000577)	1.65414322

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK3	3.76209101
2	MARK1	3.22346538
3	PINK1	3.15971795
4	CASK	3.15637446
5	MAP3K4	2.83504868
6	BCR	2.76268962
7	MAP4K2	2.70725305
8	TRIM28	2.45652745
9	MAP2K7	2.41642865
10	EPHA4	2.37894467
11	TNIK	2.22373687
12	STK38L	2.18447632
13	DYRK2	2.17064658
14	FRK	2.03159935
15	MAPK13	1.86674365
16	CSNK1G2	1.86511645
17	BMPR1B	1.82093719
18	CSNK1G3	1.73787968
19	DYRK3	1.71035350
20	CSNK1G1	1.64989473
21	CSNK1A1L	1.64394902
22	SRPK1	1.55528037
23	PNCK	1.43559037
24	ZAK	1.43548527
25	NTRK3	1.41485981
26	CDK19	1.35873920
27	NTRK2	1.28888074
28	MINK1	1.24627020
29	PLK2	1.22639096
30	EPHB2	1.22241359
31	GRK1	1.17476604
32	PAK3	1.16369268
33	ADRBK2	1.12139720
34	EPHA3	1.11647414
35	ERBB3	1.09476761
36	MKNK1	1.07757464
37	INSRR	1.00242188
38	MKNK2	0.99651807
39	MAP2K4	0.97274088
40	PRKCG	0.96258201
41	NUAK1	0.92952356
42	FGFR2	0.88745635
43	PRKCE	0.87307108
44	DYRK1A	0.85794298
45	VRK1	0.85773882
46	OBSCN	0.83994148
47	BCKDK	0.81210612
48	OXSR1	0.80261789
49	PKN1	0.80074631
50	PLK3	0.77202341
51	UHMK1	0.77181875
52	CAMK2A	0.75528360
53	CDC7	0.73336753
54	CDK5	0.71174106
55	TSSK6	0.70733876
56	RPS6KA4	0.68260084
57	CDK3	0.67880901
58	MAPK15	0.66754509
59	DYRK1B	0.62896438
60	LATS1	0.62484439
61	WEE1	0.61284435
62	STK39	0.59804147
63	CSNK1D	0.58441047
64	BRSK2	0.58005682
65	CSNK1A1	0.57983051
66	PLK1	0.56815482
67	SGK494	0.56105901
68	SGK223	0.56105901
69	PAK6	0.52438826
70	LIMK1	0.51934443
71	CCNB1	0.51216694
72	PRKG1	0.50610463
73	TLK1	0.50446979
74	GRK5	0.48359980
75	ACVR1B	0.46943153
76	SGK2	0.46752785
77	PLK4	0.46208698
78	PRKACA	0.44861428
79	CAMK2B	0.44643397
80	DAPK2	0.44110315
81	CAMKK2	0.43926664
82	ATM	0.43383409
83	PHKG2	0.43003836
84	PHKG1	0.43003836
85	SIK2	0.42774037
86	ADRBK1	0.42303375
87	TIE1	0.40390495
88	FLT3	0.39877372
89	CSNK1E	0.38779155
90	PRKACB	0.38529881
91	NEK2	0.37815380
92	RPS6KA5	0.36740424
93	BRD4	0.34866587
94	STK11	0.34804051
95	CAMK4	0.34647799
96	FGFR1	0.34120658
97	CDK14	0.33711391
98	PRKCZ	0.32566128
99	PTK2B	0.32344809
100	ATR	0.32230396

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.27961163
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.54743094
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.40585274
4	Protein export_Homo sapiens_hsa03060	2.30002251
5	Phototransduction_Homo sapiens_hsa04744	2.24119856
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.23982484
7	GABAergic synapse_Homo sapiens_hsa04727	2.10765190
8	Parkinsons disease_Homo sapiens_hsa05012	2.00372250
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.00218312
10	Butanoate metabolism_Homo sapiens_hsa00650	1.99741458
11	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.95285436
12	Morphine addiction_Homo sapiens_hsa05032	1.88101026
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.83192422
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.77285957
15	Taste transduction_Homo sapiens_hsa04742	1.72067597
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.65201173
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.65073023
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.60650688
19	Circadian entrainment_Homo sapiens_hsa04713	1.59631577
20	Huntingtons disease_Homo sapiens_hsa05016	1.54803512
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.54696068
22	Propanoate metabolism_Homo sapiens_hsa00640	1.53607229
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.49449921
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.45762216
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42776100
26	Basal transcription factors_Homo sapiens_hsa03022	1.41117809
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.38441045
28	Dopaminergic synapse_Homo sapiens_hsa04728	1.35806548
29	Cocaine addiction_Homo sapiens_hsa05030	1.33288905
30	Linoleic acid metabolism_Homo sapiens_hsa00591	1.33055362
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31687159
32	Alzheimers disease_Homo sapiens_hsa05010	1.27555554
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.27428161
34	Olfactory transduction_Homo sapiens_hsa04740	1.24961684
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.22583019
36	Axon guidance_Homo sapiens_hsa04360	1.22403702
37	Circadian rhythm_Homo sapiens_hsa04710	1.21753187
38	Basal cell carcinoma_Homo sapiens_hsa05217	1.19507048
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.18812208
40	Caffeine metabolism_Homo sapiens_hsa00232	1.11096553
41	Serotonergic synapse_Homo sapiens_hsa04726	1.08890877
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.07796722
43	Long-term depression_Homo sapiens_hsa04730	1.05540243
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.03579038
45	RNA polymerase_Homo sapiens_hsa03020	1.02866452
46	Hippo signaling pathway_Homo sapiens_hsa04390	1.01511683
47	Regulation of autophagy_Homo sapiens_hsa04140	0.99213945
48	Insulin secretion_Homo sapiens_hsa04911	0.98711993
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.96995037
50	Homologous recombination_Homo sapiens_hsa03440	0.95690366
51	Amphetamine addiction_Homo sapiens_hsa05031	0.95582467
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.93922062
53	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.92609282
54	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.88482598
55	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88065167
56	RNA degradation_Homo sapiens_hsa03018	0.87388856
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85926668
58	Retinol metabolism_Homo sapiens_hsa00830	0.82780795
59	Salivary secretion_Homo sapiens_hsa04970	0.82157071
60	Cholinergic synapse_Homo sapiens_hsa04725	0.81208630
61	Peroxisome_Homo sapiens_hsa04146	0.80864383
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.79787305
63	Alcoholism_Homo sapiens_hsa05034	0.77661001
64	Wnt signaling pathway_Homo sapiens_hsa04310	0.75666848
65	Gap junction_Homo sapiens_hsa04540	0.74420195
66	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.72604281
67	Fatty acid elongation_Homo sapiens_hsa00062	0.69952976
68	Oocyte meiosis_Homo sapiens_hsa04114	0.69768504
69	Mismatch repair_Homo sapiens_hsa03430	0.69291094
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.69279468
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.68273631
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68040553
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67126601
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63688085
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63579868
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62782196
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.60926092
78	Folate biosynthesis_Homo sapiens_hsa00790	0.59400425
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59320552
80	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.59062430
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58017626
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57629304
83	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.56509814
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55417922
85	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54054739
86	Glycerolipid metabolism_Homo sapiens_hsa00561	0.53907922
87	cAMP signaling pathway_Homo sapiens_hsa04024	0.53198862
88	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.53077094
89	Metabolic pathways_Homo sapiens_hsa01100	0.52639815
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51370558
91	Gastric acid secretion_Homo sapiens_hsa04971	0.49454988
92	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.48687636
93	Renin secretion_Homo sapiens_hsa04924	0.43316106
94	One carbon pool by folate_Homo sapiens_hsa00670	0.42028372
95	Melanogenesis_Homo sapiens_hsa04916	0.41739018
96	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.41183447
97	Spliceosome_Homo sapiens_hsa03040	0.40687126
98	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.39743838
99	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39621413
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39174282

C14ORF37

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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