C14ORF79

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)8.98446241
2cilium movement (GO:0003341)8.42204926
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.32740012
4epithelial cilium movement (GO:0003351)8.20004302
5motile cilium assembly (GO:0044458)7.43998253
6axoneme assembly (GO:0035082)6.28952252
7regulation of cilium movement (GO:0003352)5.39064833
8left/right pattern formation (GO:0060972)5.19941037
9intraciliary transport (GO:0042073)4.73192703
10cilium organization (GO:0044782)4.69187498
11cilium assembly (GO:0042384)4.56454858
12protein localization to cilium (GO:0061512)4.52722754
13behavioral response to nicotine (GO:0035095)4.50185526
14cilium morphogenesis (GO:0060271)4.24736963
15ventricular system development (GO:0021591)3.90800885
16regulation of microtubule-based movement (GO:0060632)3.88690387
17left/right axis specification (GO:0070986)3.87888209
18piRNA metabolic process (GO:0034587)3.87137674
19microtubule bundle formation (GO:0001578)3.68300619
20cornea development in camera-type eye (GO:0061303)3.49281129
21cellular component assembly involved in morphogenesis (GO:0010927)3.41580361
22nonmotile primary cilium assembly (GO:0035058)3.35312005
23negative regulation of T cell differentiation in thymus (GO:0033085)3.33616042
24DNA methylation involved in gamete generation (GO:0043046)3.25193700
25preassembly of GPI anchor in ER membrane (GO:0016254)3.20115311
26protein polyglutamylation (GO:0018095)3.17331137
27male meiosis I (GO:0007141)3.12557028
28smoothened signaling pathway (GO:0007224)3.07768567
29sperm motility (GO:0030317)3.04657953
30cell projection assembly (GO:0030031)2.90214658
31nucleoside diphosphate phosphorylation (GO:0006165)2.87750569
32GTP biosynthetic process (GO:0006183)2.85620791
33cellular ketone body metabolic process (GO:0046950)2.81559914
34microtubule-based movement (GO:0007018)2.78846824
35nucleotide transmembrane transport (GO:1901679)2.77689120
36spinal cord motor neuron differentiation (GO:0021522)2.76735586
37determination of left/right symmetry (GO:0007368)2.71234761
38ubiquinone biosynthetic process (GO:0006744)2.67970351
39cellular response to ATP (GO:0071318)2.67077306
40organic cation transport (GO:0015695)2.64118933
41GPI anchor metabolic process (GO:0006505)2.62389967
42synapsis (GO:0007129)2.59606532
43retinal cone cell development (GO:0046549)2.58763016
44GPI anchor biosynthetic process (GO:0006506)2.57839160
45fucose catabolic process (GO:0019317)2.57654432
46L-fucose metabolic process (GO:0042354)2.57654432
47L-fucose catabolic process (GO:0042355)2.57654432
48detection of light stimulus involved in visual perception (GO:0050908)2.56150325
49detection of light stimulus involved in sensory perception (GO:0050962)2.56150325
50vitamin transmembrane transport (GO:0035461)2.56003443
51photoreceptor cell maintenance (GO:0045494)2.55353241
52determination of bilateral symmetry (GO:0009855)2.53630366
53ubiquinone metabolic process (GO:0006743)2.53338175
54centriole assembly (GO:0098534)2.53144787
55ketone body metabolic process (GO:1902224)2.51177991
56specification of symmetry (GO:0009799)2.48138277
57appendage development (GO:0048736)2.44732074
58limb development (GO:0060173)2.44732074
59response to xenobiotic stimulus (GO:0009410)2.44227151
60photoreceptor cell development (GO:0042461)2.44218215
61retinal rod cell development (GO:0046548)2.44160396
62C-terminal protein lipidation (GO:0006501)2.41830989
63mannosylation (GO:0097502)2.40889150
64protein complex biogenesis (GO:0070271)2.40853234
65establishment or maintenance of monopolar cell polarity (GO:0061339)2.40519444
66establishment of monopolar cell polarity (GO:0061162)2.40519444
67reciprocal DNA recombination (GO:0035825)2.40144257
68reciprocal meiotic recombination (GO:0007131)2.40144257
69primary alcohol catabolic process (GO:0034310)2.39501764
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.38613166
71C-terminal protein amino acid modification (GO:0018410)2.38243389
72microtubule depolymerization (GO:0007019)2.37599691
73spermatid development (GO:0007286)2.36859779
74establishment of tissue polarity (GO:0007164)2.36587019
75establishment of planar polarity (GO:0001736)2.36587019
76lung epithelium development (GO:0060428)2.35668079
77UTP biosynthetic process (GO:0006228)2.34131380
78meiosis I (GO:0007127)2.33970408
79male meiosis (GO:0007140)2.32142373
80cysteine metabolic process (GO:0006534)2.31542891
81glutathione derivative metabolic process (GO:1901685)2.28942409
82glutathione derivative biosynthetic process (GO:1901687)2.28942409
83multicellular organism reproduction (GO:0032504)2.27929087
84tRNA modification (GO:0006400)2.25711580
85diterpenoid biosynthetic process (GO:0016102)2.25318532
86neurotransmitter metabolic process (GO:0042133)2.24926004
87behavioral response to ethanol (GO:0048149)2.23861022
88neurotransmitter catabolic process (GO:0042135)2.23164921
89respiratory chain complex IV assembly (GO:0008535)2.22290596
90base-excision repair, AP site formation (GO:0006285)2.21998868
91mitochondrial respiratory chain complex assembly (GO:0033108)2.21664093
92urinary tract smooth muscle contraction (GO:0014848)2.21632843
93nephron epithelium morphogenesis (GO:0072088)2.20610437
94nephron tubule morphogenesis (GO:0072078)2.20610437
95regulation of collateral sprouting (GO:0048670)2.19839647
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.19690490
97eye photoreceptor cell development (GO:0042462)2.19033557
98UTP metabolic process (GO:0046051)2.18705908
99exogenous drug catabolic process (GO:0042738)2.18527439
100axonemal dynein complex assembly (GO:0070286)10.3809992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.55925921
2ZNF274_21170338_ChIP-Seq_K562_Hela3.00590490
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31277159
4VDR_22108803_ChIP-Seq_LS180_Human2.31080364
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.30785015
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.16156302
7EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.88620837
8CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80138691
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77896502
10CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73598612
11EZH2_27294783_Chip-Seq_ESCs_Mouse1.72168099
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63013318
13DROSHA_22980978_ChIP-Seq_HELA_Human1.60693302
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.59828566
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56707596
16REST_21632747_ChIP-Seq_MESCs_Mouse1.54117744
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.53722298
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52553364
19GBX2_23144817_ChIP-Seq_PC3_Human1.51597813
20* ERA_21632823_ChIP-Seq_H3396_Human1.49913237
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47766575
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47306990
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45248016
24EWS_26573619_Chip-Seq_HEK293_Human1.44437040
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.43190592
26FUS_26573619_Chip-Seq_HEK293_Human1.42586485
27SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39950653
28TP53_22573176_ChIP-Seq_HFKS_Human1.39196159
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38678976
30TAF15_26573619_Chip-Seq_HEK293_Human1.38145894
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33871624
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33132926
33ER_23166858_ChIP-Seq_MCF-7_Human1.30757181
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27191323
35P68_20966046_ChIP-Seq_HELA_Human1.26783840
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26738996
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25702662
38CTCF_20526341_ChIP-Seq_ESCs_Human1.25216009
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23383288
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.22908682
41MYC_19829295_ChIP-Seq_ESCs_Human1.21981184
42RNF2_27304074_Chip-Seq_NSC_Mouse1.20682933
43PHF8_20622854_ChIP-Seq_HELA_Human1.20064485
44NCOR_22424771_ChIP-Seq_293T_Human1.19560507
45CTCF_27219007_Chip-Seq_Bcells_Human1.17995965
46E2F1_20622854_ChIP-Seq_HELA_Human1.17430925
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.17365013
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17365013
49HOXB7_26014856_ChIP-Seq_BT474_Human1.17115940
50BCAT_22108803_ChIP-Seq_LS180_Human1.16573927
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.16347276
52RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16251798
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15606154
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14527806
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.13842570
56OCT4_20526341_ChIP-Seq_ESCs_Human1.13688170
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.13500229
58IGF1R_20145208_ChIP-Seq_DFB_Human1.11794552
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11660908
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11025622
61EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10924337
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.10347274
63MYC_18940864_ChIP-ChIP_HL60_Human1.10200432
64EZH2_22144423_ChIP-Seq_EOC_Human1.10020171
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09945829
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.08992457
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08534092
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07430038
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.04785182
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.04147353
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03286194
72CBP_20019798_ChIP-Seq_JUKART_Human1.03286194
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02706920
74P53_21459846_ChIP-Seq_SAOS-2_Human1.02666632
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.02485923
76TAF2_19829295_ChIP-Seq_ESCs_Human1.01510173
77IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99779885
78SRF_21415370_ChIP-Seq_HL-1_Mouse0.99746084
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99349693
80FOXP1_21924763_ChIP-Seq_HESCs_Human0.98618510
81AR_20517297_ChIP-Seq_VCAP_Human0.98526619
82KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97841034
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96365326
84RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95350040
85PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94857128
86JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94781386
87ERG_21242973_ChIP-ChIP_JURKAT_Human0.93454854
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93143825
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.92855788
90STAT3_23295773_ChIP-Seq_U87_Human0.91979345
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.90969346
92AR_25329375_ChIP-Seq_VCAP_Human0.90907688
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90846102
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89762536
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89656447
96POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89448789
97MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89443804
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89244195
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88292440
100SOX2_21211035_ChIP-Seq_LN229_Human0.87588953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.93358495
2MP0008875_abnormal_xenobiotic_pharmacok3.48574859
3MP0003136_yellow_coat_color2.80149595
4MP0001968_abnormal_touch/_nociception2.45778260
5MP0004133_heterotaxia2.45449040
6MP0008789_abnormal_olfactory_epithelium2.38841042
7MP0002160_abnormal_reproductive_system2.22006605
8MP0004043_abnormal_pH_regulation2.21253916
9MP0001984_abnormal_olfaction2.18204252
10MP0005551_abnormal_eye_electrophysiolog2.03180304
11MP0000566_synostosis1.98244575
12MP0010030_abnormal_orbit_morphology1.98070321
13MP0002735_abnormal_chemical_nociception1.98024695
14MP0001986_abnormal_taste_sensitivity1.95980018
15MP0002638_abnormal_pupillary_reflex1.90479817
16MP0002736_abnormal_nociception_after1.90113539
17MP0008877_abnormal_DNA_methylation1.83763913
18MP0005394_taste/olfaction_phenotype1.79054787
19MP0005499_abnormal_olfactory_system1.79054787
20MP0000383_abnormal_hair_follicle1.77253086
21MP0009046_muscle_twitch1.63018302
22MP0002102_abnormal_ear_morphology1.61530804
23MP0002938_white_spotting1.60570544
24MP0009780_abnormal_chondrocyte_physiolo1.59342653
25MP0002876_abnormal_thyroid_physiology1.56327962
26MP0006292_abnormal_olfactory_placode1.55389549
27MP0001502_abnormal_circadian_rhythm1.54457474
28MP0005423_abnormal_somatic_nervous1.54327501
29MP0000427_abnormal_hair_cycle1.53408446
30MP0006276_abnormal_autonomic_nervous1.52772112
31MP0002277_abnormal_respiratory_mucosa1.51636154
32MP0009745_abnormal_behavioral_response1.51171382
33MP0005389_reproductive_system_phenotype1.48741963
34MP0005646_abnormal_pituitary_gland1.46769973
35MP0002822_catalepsy1.46679161
36MP0001529_abnormal_vocalization1.43654387
37MP0008872_abnormal_physiological_respon1.43448579
38MP0005377_hearing/vestibular/ear_phenot1.42949607
39MP0003878_abnormal_ear_physiology1.42949607
40MP0005253_abnormal_eye_physiology1.42647697
41MP0003011_delayed_dark_adaptation1.38588239
42MP0002282_abnormal_trachea_morphology1.36854008
43MP0002734_abnormal_mechanical_nocicepti1.34752471
44MP0002909_abnormal_adrenal_gland1.33677095
45MP0002572_abnormal_emotion/affect_behav1.33647233
46MP0005171_absent_coat_pigmentation1.32400576
47MP0000631_abnormal_neuroendocrine_gland1.32383103
48MP0006072_abnormal_retinal_apoptosis1.31198747
49MP0005174_abnormal_tail_pigmentation1.29535993
50MP0001970_abnormal_pain_threshold1.23951894
51MP0002557_abnormal_social/conspecific_i1.22955967
52MP0000026_abnormal_inner_ear1.21680558
53MP0002272_abnormal_nervous_system1.21428682
54MP0003880_abnormal_central_pattern1.20339983
55MP0004885_abnormal_endolymph1.19080626
56MP0003195_calcinosis1.18050767
57MP0003698_abnormal_male_reproductive1.17820878
58MP0004142_abnormal_muscle_tone1.15873679
59MP0000778_abnormal_nervous_system1.12692584
60MP0001486_abnormal_startle_reflex1.12182792
61MP0003787_abnormal_imprinting1.08774657
62MP0002928_abnormal_bile_duct1.08496339
63MP0001929_abnormal_gametogenesis1.08077977
64MP0002063_abnormal_learning/memory/cond1.07589077
65MP0001905_abnormal_dopamine_level1.07310354
66MP0002210_abnormal_sex_determination1.06481218
67MP0001485_abnormal_pinna_reflex1.06436834
68MP0002064_seizures1.03476595
69MP0000049_abnormal_middle_ear1.03331213
70MP0010678_abnormal_skin_adnexa1.01366521
71MP0001188_hyperpigmentation0.99664359
72MP0005195_abnormal_posterior_eye0.98231025
73MP0002733_abnormal_thermal_nociception0.97157165
74MP0001346_abnormal_lacrimal_gland0.96776248
75MP0000013_abnormal_adipose_tissue0.96014435
76MP0001919_abnormal_reproductive_system0.95289882
77MP0005083_abnormal_biliary_tract0.95247363
78MP0003635_abnormal_synaptic_transmissio0.94985922
79MP0005645_abnormal_hypothalamus_physiol0.92761350
80MP0002234_abnormal_pharynx_morphology0.92326429
81MP0001324_abnormal_eye_pigmentation0.91108351
82MP0004019_abnormal_vitamin_homeostasis0.90175406
83MP0002752_abnormal_somatic_nervous0.89529217
84MP0001293_anophthalmia0.89120087
85MP0000955_abnormal_spinal_cord0.89108660
86MP0002067_abnormal_sensory_capabilities0.88688852
87MP0002249_abnormal_larynx_morphology0.88186219
88MP0003937_abnormal_limbs/digits/tail_de0.87846437
89MP0005410_abnormal_fertilization0.87119848
90MP0002184_abnormal_innervation0.86381541
91MP0003122_maternal_imprinting0.86197588
92MP0005386_behavior/neurological_phenoty0.85430021
93MP0004924_abnormal_behavior0.85430021
94MP0003121_genomic_imprinting0.84318319
95MP0001145_abnormal_male_reproductive0.83272700
96MP0001963_abnormal_hearing_physiology0.82501586
97MP0000653_abnormal_sex_gland0.81264629
98MP0002882_abnormal_neuron_morphology0.80276499
99MP0000538_abnormal_urinary_bladder0.80234241
100MP0005391_vision/eye_phenotype0.79957117

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.99076194
2Abnormal respiratory epithelium morphology (HP:0012253)7.34477502
3Abnormal respiratory motile cilium morphology (HP:0005938)7.34477502
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.13536811
5Absent/shortened dynein arms (HP:0200106)7.13536811
6Abnormal respiratory motile cilium physiology (HP:0012261)6.85669283
7Abnormal ciliary motility (HP:0012262)6.67466989
8Rhinitis (HP:0012384)6.12214928
9Chronic bronchitis (HP:0004469)4.77094356
10Pancreatic fibrosis (HP:0100732)4.56105877
11True hermaphroditism (HP:0010459)4.46349314
12Abnormality of midbrain morphology (HP:0002418)4.41317471
13Molar tooth sign on MRI (HP:0002419)4.41317471
14Pancreatic cysts (HP:0001737)4.32491349
15Nephronophthisis (HP:0000090)4.27487317
16Bronchiectasis (HP:0002110)3.90784711
17Cystic liver disease (HP:0006706)3.80207550
18Occipital encephalocele (HP:0002085)3.76740396
19Chronic hepatic failure (HP:0100626)3.71897916
20Abnormality of the renal medulla (HP:0100957)3.44479416
21Nasal polyposis (HP:0100582)3.21825512
22Medial flaring of the eyebrow (HP:0010747)3.18174789
23Gait imbalance (HP:0002141)2.85822724
24Tubular atrophy (HP:0000092)2.78411976
25Anencephaly (HP:0002323)2.75441567
26Postaxial foot polydactyly (HP:0001830)2.75300037
27Congenital primary aphakia (HP:0007707)2.74312684
28Congenital hepatic fibrosis (HP:0002612)2.73215776
29Congenital stationary night blindness (HP:0007642)2.72961301
30Aplasia/Hypoplasia of the tongue (HP:0010295)2.72297700
31Sclerocornea (HP:0000647)2.62269112
32Infertility (HP:0000789)2.53725893
33Nephrogenic diabetes insipidus (HP:0009806)2.47891277
34Tubulointerstitial nephritis (HP:0001970)2.47331820
35Abnormality of the nasal mucosa (HP:0000433)2.44943157
36Male pseudohermaphroditism (HP:0000037)2.34566646
37Furrowed tongue (HP:0000221)2.31877330
38Abnormal drinking behavior (HP:0030082)2.27813677
39Polydipsia (HP:0001959)2.27813677
40Type II lissencephaly (HP:0007260)2.23712821
41Rib fusion (HP:0000902)2.18254678
42Attenuation of retinal blood vessels (HP:0007843)2.17919155
43Decreased central vision (HP:0007663)2.11291579
44Chronic sinusitis (HP:0011109)2.10039617
45Postaxial hand polydactyly (HP:0001162)2.10011926
46Genital tract atresia (HP:0001827)2.01636479
47Abnormality of the renal cortex (HP:0011035)2.01606898
48Vaginal atresia (HP:0000148)1.95855548
49Bronchitis (HP:0012387)1.92921811
50Poor coordination (HP:0002370)1.92722595
51Decreased circulating renin level (HP:0003351)1.91483037
52Preaxial hand polydactyly (HP:0001177)1.89316983
53Testicular atrophy (HP:0000029)1.88245691
54Bile duct proliferation (HP:0001408)1.88164654
55Abnormal biliary tract physiology (HP:0012439)1.88164654
56Bony spicule pigmentary retinopathy (HP:0007737)1.84011582
57Oculomotor apraxia (HP:0000657)1.82146880
58Abnormal rod and cone electroretinograms (HP:0008323)1.79522158
59Aplasia/Hypoplasia of the spleen (HP:0010451)1.77569377
60Retinitis pigmentosa (HP:0000510)1.77352031
61Retinal dysplasia (HP:0007973)1.77172009
62Recurrent sinusitis (HP:0011108)1.77094234
63Increased hepatocellular lipid droplets (HP:0006565)1.73820262
64Lipid accumulation in hepatocytes (HP:0006561)1.73331264
65Optic nerve coloboma (HP:0000588)1.70877547
66Aplasia/Hypoplasia of the lens (HP:0008063)1.70747841
67Stage 5 chronic kidney disease (HP:0003774)1.69405019
68Asplenia (HP:0001746)1.66418091
69Tubulointerstitial abnormality (HP:0001969)1.63418737
70Mesangial abnormality (HP:0001966)1.63085567
71Absent speech (HP:0001344)1.62539485
72Bell-shaped thorax (HP:0001591)1.61633524
73Polyuria (HP:0000103)1.61542095
74Large for gestational age (HP:0001520)1.60948397
75Chorioretinal atrophy (HP:0000533)1.58929148
76Renal Fanconi syndrome (HP:0001994)1.58083557
77Pendular nystagmus (HP:0012043)1.57829681
78Cerebellar dysplasia (HP:0007033)1.56636263
79Mitochondrial inheritance (HP:0001427)1.54189253
80Aganglionic megacolon (HP:0002251)1.53190920
81Concave nail (HP:0001598)1.52651531
82Male infertility (HP:0003251)1.52278850
83Narrow forehead (HP:0000341)1.48500959
84Prominent nasal bridge (HP:0000426)1.47929310
85Hyperventilation (HP:0002883)1.47917152
86Chronic otitis media (HP:0000389)1.46579612
87Recurrent otitis media (HP:0000403)1.45764124
88Disproportionate short-trunk short stature (HP:0003521)1.44812244
89Multicystic kidney dysplasia (HP:0000003)1.44369961
90Decreased electroretinogram (ERG) amplitude (HP:0000654)1.43375836
91Abnormality of macular pigmentation (HP:0008002)1.43337263
92Increased CSF lactate (HP:0002490)1.42596379
93Hepatocellular necrosis (HP:0001404)1.42430919
94Severe muscular hypotonia (HP:0006829)1.42085050
95Renal dysplasia (HP:0000110)1.41411298
96Progressive cerebellar ataxia (HP:0002073)1.40373022
97Aplasia/Hypoplasia of the patella (HP:0006498)1.40080333
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.39697693
99Lissencephaly (HP:0001339)1.39608103
100Nephropathy (HP:0000112)1.39217324

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.70894383
2FRK3.26308422
3TLK12.91721000
4INSRR2.90672745
5ADRBK22.70308988
6WNK42.64034432
7EPHA22.58013338
8PNCK2.48886502
9WNK32.08603538
10GRK11.97037671
11MAP4K21.94805759
12PINK11.81541476
13MAPKAPK31.71520552
14MAPK131.69821295
15MARK11.68813521
16NME11.68358643
17ZAK1.62959727
18NUAK11.58754418
19CASK1.48789805
20BMPR1B1.45789904
21VRK21.39762857
22BCKDK1.30008679
23MAP3K41.27501780
24PRKD31.24665192
25PTK2B1.24169404
26ADRBK11.21825350
27DYRK21.20812387
28PHKG11.19515508
29PHKG21.19515508
30MUSK1.18196087
31MST41.17631045
32TNIK1.13996197
33EPHB21.13960059
34MAP2K71.13017946
35STK391.11985386
36NTRK21.10692077
37OXSR11.10348514
38STK161.06668337
39SIK21.03458470
40MET1.00500477
41DAPK20.98847700
42CSNK1G20.95989064
43PRKCI0.95352043
44STK38L0.95048036
45CSNK1G30.93404857
46PIM20.92549783
47PAK30.92208446
48EPHA40.92175213
49CSNK1A1L0.88617129
50PRKCG0.82294144
51MST1R0.78018022
52MAP2K20.75838214
53MAPKAPK50.74187846
54PRKCE0.72392618
55BCR0.71808651
56CSNK1G10.70839581
57ACVR1B0.68224125
58TRIM280.66488286
59TSSK60.65445467
60VRK10.64463892
61RPS6KA50.61285972
62TIE10.60019394
63WEE10.59465832
64IRAK10.57253181
65LIMK10.57217893
66PLK10.56771860
67BRSK20.56301072
68PBK0.55747649
69FGFR20.55306857
70CHUK0.55294019
71AURKA0.54679870
72MAP2K60.54290035
73MAP2K40.52760131
74LATS10.51850026
75PRKCZ0.51705327
76CAMKK10.50070582
77DYRK30.48430863
78CAMKK20.47802956
79ERBB30.46341084
80NTRK10.43581029
81RPS6KA20.42939144
82CAMK2A0.42714890
83LMTK20.41928472
84NTRK30.41690982
85ERBB20.40674643
86PRKACA0.39769162
87FER0.38518422
88CSNK1A10.38290123
89STK380.38158751
90PRKD20.38087336
91RPS6KA60.37190912
92PRKAA10.36214353
93STK110.35453839
94DYRK1A0.35198742
95EPHA30.35058461
96CAMK1G0.32165542
97PLK20.31745813
98PRKCA0.31081243
99CAMK2G0.30362636
100NEK60.29549321

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.22533560
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.11523873
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.31452914
4Oxidative phosphorylation_Homo sapiens_hsa001902.27579336
5Huntingtons disease_Homo sapiens_hsa050162.15850908
6Phototransduction_Homo sapiens_hsa047442.15826033
7Linoleic acid metabolism_Homo sapiens_hsa005912.13991807
8Nicotine addiction_Homo sapiens_hsa050332.12189054
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08862064
10Sulfur relay system_Homo sapiens_hsa041222.07458742
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07245108
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07218981
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97602846
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.97319582
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90360815
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.80283138
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.78768627
18Chemical carcinogenesis_Homo sapiens_hsa052041.73907773
19Butanoate metabolism_Homo sapiens_hsa006501.65652794
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58030883
21Protein export_Homo sapiens_hsa030601.57422549
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55225451
23beta-Alanine metabolism_Homo sapiens_hsa004101.54691381
24RNA polymerase_Homo sapiens_hsa030201.54229633
25Parkinsons disease_Homo sapiens_hsa050121.54176444
26Phenylalanine metabolism_Homo sapiens_hsa003601.40730690
27Nitrogen metabolism_Homo sapiens_hsa009101.38838116
28Histidine metabolism_Homo sapiens_hsa003401.37322128
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37239809
30Ether lipid metabolism_Homo sapiens_hsa005651.35797309
31Homologous recombination_Homo sapiens_hsa034401.33808008
32Taste transduction_Homo sapiens_hsa047421.31373006
33Peroxisome_Homo sapiens_hsa041461.28229642
34Glycosaminoglycan degradation_Homo sapiens_hsa005311.26595458
35Tryptophan metabolism_Homo sapiens_hsa003801.22486234
36Fanconi anemia pathway_Homo sapiens_hsa034601.18986229
37ABC transporters_Homo sapiens_hsa020101.16591313
38Basal transcription factors_Homo sapiens_hsa030221.14395840
39Glutathione metabolism_Homo sapiens_hsa004801.14106334
40Sulfur metabolism_Homo sapiens_hsa009201.12291441
41Selenocompound metabolism_Homo sapiens_hsa004501.11871959
42Caffeine metabolism_Homo sapiens_hsa002321.10522347
43Cardiac muscle contraction_Homo sapiens_hsa042601.07801145
44Tyrosine metabolism_Homo sapiens_hsa003501.06967298
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06276184
46Alzheimers disease_Homo sapiens_hsa050101.04702650
47Circadian rhythm_Homo sapiens_hsa047101.02774780
48Hedgehog signaling pathway_Homo sapiens_hsa043401.02048221
49Basal cell carcinoma_Homo sapiens_hsa052170.99262861
50Collecting duct acid secretion_Homo sapiens_hsa049660.97774546
51Sphingolipid metabolism_Homo sapiens_hsa006000.95531438
52Steroid biosynthesis_Homo sapiens_hsa001000.95230279
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93113790
54Cocaine addiction_Homo sapiens_hsa050300.92693543
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.92227228
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87248478
57Retinol metabolism_Homo sapiens_hsa008300.82566214
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82299054
59Ovarian steroidogenesis_Homo sapiens_hsa049130.82091082
60Metabolic pathways_Homo sapiens_hsa011000.80514491
61GABAergic synapse_Homo sapiens_hsa047270.78621869
62Arachidonic acid metabolism_Homo sapiens_hsa005900.77685903
63Glutamatergic synapse_Homo sapiens_hsa047240.77130409
64Morphine addiction_Homo sapiens_hsa050320.76435204
65Insulin secretion_Homo sapiens_hsa049110.76318335
66Purine metabolism_Homo sapiens_hsa002300.76288890
67Synaptic vesicle cycle_Homo sapiens_hsa047210.76120146
68Propanoate metabolism_Homo sapiens_hsa006400.75538994
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75055528
70Salivary secretion_Homo sapiens_hsa049700.74823858
71Circadian entrainment_Homo sapiens_hsa047130.73566147
72Folate biosynthesis_Homo sapiens_hsa007900.71969875
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71521514
74Regulation of autophagy_Homo sapiens_hsa041400.71354960
75Olfactory transduction_Homo sapiens_hsa047400.70038688
76Serotonergic synapse_Homo sapiens_hsa047260.69908519
77Nucleotide excision repair_Homo sapiens_hsa034200.66173770
78Pyrimidine metabolism_Homo sapiens_hsa002400.64794164
79RNA degradation_Homo sapiens_hsa030180.62606264
80Hippo signaling pathway_Homo sapiens_hsa043900.62172788
81Axon guidance_Homo sapiens_hsa043600.61754789
82One carbon pool by folate_Homo sapiens_hsa006700.59034849
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57360365
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.57293990
85Vitamin digestion and absorption_Homo sapiens_hsa049770.51626632
86Calcium signaling pathway_Homo sapiens_hsa040200.50440155
87Mineral absorption_Homo sapiens_hsa049780.49348040
88Dopaminergic synapse_Homo sapiens_hsa047280.45359820
89Ribosome_Homo sapiens_hsa030100.43480471
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.42682016
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.41249941
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.40518151
93Amphetamine addiction_Homo sapiens_hsa050310.40374291
94Arginine and proline metabolism_Homo sapiens_hsa003300.38564099
95Base excision repair_Homo sapiens_hsa034100.37733537
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37210823
97Fatty acid metabolism_Homo sapiens_hsa012120.33613278
98Fatty acid elongation_Homo sapiens_hsa000620.33048186
99Fatty acid degradation_Homo sapiens_hsa000710.32341836
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32117476

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