ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA methylation involved in gamete generation (GO:0043046)	4.40625235
2	negative regulation of phagocytosis (GO:0050765)	3.97927058
3	piRNA metabolic process (GO:0034587)	3.83326805
4	positive regulation of granulocyte differentiation (GO:0030854)	3.79787851
5	preassembly of GPI anchor in ER membrane (GO:0016254)	3.62428265
6	respiratory chain complex IV assembly (GO:0008535)	3.62282319
7	peptidyl-histidine modification (GO:0018202)	3.57078681
8	synapsis (GO:0007129)	3.47702489
9	regulation of B cell apoptotic process (GO:0002902)	3.45835150
10	positive regulation of B cell differentiation (GO:0045579)	3.25337984
11	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.24991125
12	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.24991125
13	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.24991125
14	modulation by symbiont of host immune response (GO:0052553)	3.24991125
15	positive regulation by symbiont of host defense response (GO:0052509)	3.24991125
16	modulation by symbiont of host defense response (GO:0052031)	3.24991125
17	cytochrome complex assembly (GO:0017004)	3.22416726
18	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	3.18932720
19	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.16776802
20	positive regulation of gamma-delta T cell activation (GO:0046645)	3.04390210
21	kinetochore assembly (GO:0051382)	2.98592052
22	GPI anchor biosynthetic process (GO:0006506)	2.95854001
23	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.93733008
24	neutrophil activation involved in immune response (GO:0002283)	2.81886653
25	DNA deamination (GO:0045006)	2.79776642
26	branched-chain amino acid catabolic process (GO:0009083)	2.78948831
27	keratinocyte development (GO:0003334)	2.78500634
28	regulation of vacuole organization (GO:0044088)	2.77465540
29	kinetochore organization (GO:0051383)	2.75384015
30	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.73293590
31	C-terminal protein lipidation (GO:0006501)	2.70409957
32	regulation of autophagic vacuole assembly (GO:2000785)	2.70138215
33	T cell homeostasis (GO:0043029)	2.68269022
34	GPI anchor metabolic process (GO:0006505)	2.62313186
35	inositol phosphate catabolic process (GO:0071545)	2.61878694
36	poly(A)+ mRNA export from nucleus (GO:0016973)	2.60478867
37	regulation of granulocyte differentiation (GO:0030852)	2.58436570
38	branched-chain amino acid metabolic process (GO:0009081)	2.58360204
39	protein import into peroxisome matrix (GO:0016558)	2.56979968
40	DNA synthesis involved in DNA repair (GO:0000731)	2.54233034
41	regulation of oxidative stress-induced neuron death (GO:1903203)	2.53146844
42	oxygen transport (GO:0015671)	2.51115089
43	histone H4-K16 acetylation (GO:0043984)	2.48432382
44	water-soluble vitamin biosynthetic process (GO:0042364)	2.48112024
45	3-UTR-mediated mRNA stabilization (GO:0070935)	2.47522304
46	response to peptidoglycan (GO:0032494)	2.47365066
47	resolution of meiotic recombination intermediates (GO:0000712)	2.44779989
48	male meiosis I (GO:0007141)	2.42593106
49	rRNA modification (GO:0000154)	2.41958440
50	ribosome assembly (GO:0042255)	2.41868531
51	definitive hemopoiesis (GO:0060216)	2.38540305
52	valine metabolic process (GO:0006573)	2.37464610
53	regulation of interferon-beta biosynthetic process (GO:0045357)	2.36928904
54	erythrocyte maturation (GO:0043249)	2.36619644
55	negative regulation of erythrocyte differentiation (GO:0045647)	2.34744705
56	protein complex biogenesis (GO:0070271)	2.32912300
57	pyrimidine nucleotide catabolic process (GO:0006244)	2.32391916
58	leukocyte migration involved in inflammatory response (GO:0002523)	2.31058598
59	leukocyte degranulation (GO:0043299)	2.28620159
60	positive regulation of histone H3-K4 methylation (GO:0051571)	2.27766883
61	mitochondrial respiratory chain complex assembly (GO:0033108)	2.26280620
62	histone H2A acetylation (GO:0043968)	2.25852139
63	RNA methylation (GO:0001510)	2.25360140
64	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.23342342
65	response to host immune response (GO:0052572)	2.23342342
66	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.23303264
67	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.23303264
68	NADH dehydrogenase complex assembly (GO:0010257)	2.23303264
69	megakaryocyte development (GO:0035855)	2.22636272
70	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.22270074
71	tRNA modification (GO:0006400)	2.21423628
72	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.20199925
73	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.20199925
74	tRNA methylation (GO:0030488)	2.19989047
75	regulation of histone H3-K4 methylation (GO:0051569)	2.19657322
76	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.19275111
77	inositol phosphate dephosphorylation (GO:0046855)	2.19275111
78	DNA catabolic process, endonucleolytic (GO:0000737)	2.19176394
79	regulation of gamma-delta T cell activation (GO:0046643)	2.18349419
80	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.18111927
81	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.17225704
82	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.16961957
83	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.16961957
84	polyol catabolic process (GO:0046174)	2.16483436
85	meiosis I (GO:0007127)	2.14417005
86	protoporphyrinogen IX metabolic process (GO:0046501)	2.14321005
87	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.13120274
88	regulation of B cell differentiation (GO:0045577)	2.11831462
89	mast cell degranulation (GO:0043303)	2.10321298
90	mast cell activation involved in immune response (GO:0002279)	2.10321298
91	negative regulation of T cell apoptotic process (GO:0070233)	2.09981828
92	DNA double-strand break processing (GO:0000729)	2.09669027
93	negative regulation of translational initiation (GO:0045947)	2.09183431
94	negative regulation of B cell apoptotic process (GO:0002903)	2.08859839
95	negative regulation of cell size (GO:0045792)	2.08081676
96	negative regulation of stem cell proliferation (GO:2000647)	2.08074688
97	C-terminal protein amino acid modification (GO:0018410)	2.07778542
98	rRNA methylation (GO:0031167)	2.07729217
99	production of molecular mediator involved in inflammatory response (GO:0002532)	2.07676217
100	regulation of gamma-delta T cell differentiation (GO:0045586)	2.06992677

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.55752038
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.12988275
3	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.75380258
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.75117005
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.67996813
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.66789958
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.57435368
8	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.50631953
9	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.47839969
10	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.44544961
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38164994
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.22956100
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.20062271
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.18209901
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17973202
16	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.11663720
17	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.09824466
18	CIITA_25753668_ChIP-Seq_RAJI_Human	2.08122413
19	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.02132979
20	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.01730075
21	GABP_19822575_ChIP-Seq_HepG2_Human	2.01296147
22	KDM5A_27292631_Chip-Seq_BREAST_Human	1.98017456
23	SPI1_23547873_ChIP-Seq_NB4_Human	1.91350926
24	DCP1A_22483619_ChIP-Seq_HELA_Human	1.89382297
25	MYC_22102868_ChIP-Seq_BL_Human	1.83884536
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.83569011
27	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.83260200
28	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.82251400
29	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.82238019
30	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.81386195
31	VDR_21846776_ChIP-Seq_THP-1_Human	1.74149004
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.72571377
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71065680
34	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.66543512
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64902010
36	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.64467497
37	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.64191220
38	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.63704098
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.63221127
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.62364597
41	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.59008616
42	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.58493092
43	MAF_26560356_Chip-Seq_TH2_Human	1.56937973
44	ZNF263_19887448_ChIP-Seq_K562_Human	1.56032824
45	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.49009360
46	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.48159208
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.46191890
48	ZNF274_21170338_ChIP-Seq_K562_Hela	1.45855671
49	MYB_26560356_Chip-Seq_TH1_Human	1.42827340
50	GATA1_22025678_ChIP-Seq_K562_Human	1.41051587
51	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.40029134
52	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.38064411
53	XRN2_22483619_ChIP-Seq_HELA_Human	1.37969936
54	E2F7_22180533_ChIP-Seq_HELA_Human	1.37503645
55	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.37255227
56	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.36396927
57	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.32966826
58	* MAF_26560356_Chip-Seq_TH1_Human	1.32020911
59	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.31483126
60	* UTX_26944678_Chip-Seq_JUKART_Human	1.31053741
61	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.27932365
62	* MYB_26560356_Chip-Seq_TH2_Human	1.27859539
63	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.27381487
64	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.26408894
65	TFEB_21752829_ChIP-Seq_HELA_Human	1.26190622
66	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.25179643
67	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.22670376
68	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22254483
69	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.21503925
70	SCL_19346495_ChIP-Seq_HPC-7_Human	1.17208416
71	GATA3_27048872_Chip-Seq_THYMUS_Human	1.15240651
72	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.14577498
73	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.14530972
74	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.11999598
75	TTF2_22483619_ChIP-Seq_HELA_Human	1.09663879
76	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.09461971
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08540033
78	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.08314978
79	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07891636
80	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07535214
81	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.06751793
82	NCOR1_26117541_ChIP-Seq_K562_Human	1.04903906
83	VDR_24763502_ChIP-Seq_THP-1_Human	1.04855516
84	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.04197709
85	ELK1_19687146_ChIP-ChIP_HELA_Human	1.02220354
86	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.01894131
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01882028
88	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.01711672
89	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.99543789
90	SPI1_23127762_ChIP-Seq_K562_Human	0.98922317
91	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97269151
92	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96088748
93	BCL6_27268052_Chip-Seq_Bcells_Human	0.95778191
94	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.94007367
95	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.93397342
96	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.92075470
97	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.91973798
98	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.90578084
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.88800955
100	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.87487940

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002132_abnormal_respiratory_system	3.78906036
2	MP0003806_abnormal_nucleotide_metabolis	3.25701860
3	MP0003656_abnormal_erythrocyte_physiolo	3.09071937
4	MP0009697_abnormal_copulation	2.81540584
5	MP0008058_abnormal_DNA_repair	2.63545900
6	MP0002396_abnormal_hematopoietic_system	2.40184225
7	MP0003724_increased_susceptibility_to	2.11103530
8	MP0006035_abnormal_mitochondrial_morpho	2.04677336
9	MP0005075_abnormal_melanosome_morpholog	1.99503536
10	MP0006036_abnormal_mitochondrial_physio	1.95941934
11	MP0001661_extended_life_span	1.94453546
12	MP0010094_abnormal_chromosome_stability	1.91011056
13	MP0000685_abnormal_immune_system	1.90646705
14	MP0003172_abnormal_lysosome_physiology	1.84701105
15	MP0005365_abnormal_bile_salt	1.74836103
16	MP0008877_abnormal_DNA_methylation	1.72576243
17	MP0002653_abnormal_ependyma_morphology	1.72026279
18	MP0001764_abnormal_homeostasis	1.71984516
19	MP0001835_abnormal_antigen_presentation	1.70189639
20	MP0000372_irregular_coat_pigmentation	1.69575740
21	MP0008995_early_reproductive_senescence	1.69513383
22	MP0005083_abnormal_biliary_tract	1.67895700
23	MP0005451_abnormal_body_composition	1.67361826
24	MP0002722_abnormal_immune_system	1.56532124
25	MP0005058_abnormal_lysosome_morphology	1.55903292
26	MP0000689_abnormal_spleen_morphology	1.55625311
27	MP0001545_abnormal_hematopoietic_system	1.55553223
28	MP0005397_hematopoietic_system_phenotyp	1.55553223
29	MP0000703_abnormal_thymus_morphology	1.54506169
30	MP0003786_premature_aging	1.49597469
31	MP0003436_decreased_susceptibility_to	1.46309912
32	MP0002160_abnormal_reproductive_system	1.44727321
33	MP0005084_abnormal_gallbladder_morpholo	1.42282478
34	MP0002837_dystrophic_cardiac_calcinosis	1.41916096
35	MP0002398_abnormal_bone_marrow	1.41765602
36	MP0001800_abnormal_humoral_immune	1.41462295
37	MP0000516_abnormal_urinary_system	1.40865878
38	MP0005367_renal/urinary_system_phenotyp	1.40865878
39	MP0003693_abnormal_embryo_hatching	1.38065791
40	MP0005379_endocrine/exocrine_gland_phen	1.37038375
41	MP0005464_abnormal_platelet_physiology	1.35662823
42	MP0002419_abnormal_innate_immunity	1.28612124
43	MP0005220_abnormal_exocrine_pancreas	1.28289996
44	MP0003763_abnormal_thymus_physiology	1.25950913
45	MP0002723_abnormal_immune_serum	1.23628007
46	MP0004808_abnormal_hematopoietic_stem	1.23092678
47	MP0001929_abnormal_gametogenesis	1.20269581
48	MP0003186_abnormal_redox_activity	1.19772124
49	MP0002420_abnormal_adaptive_immunity	1.18237985
50	MP0008875_abnormal_xenobiotic_pharmacok	1.18002640
51	MP0005332_abnormal_amino_acid	1.17405900
52	MP0003195_calcinosis	1.16111972
53	MP0005025_abnormal_response_to	1.15753769
54	MP0001819_abnormal_immune_cell	1.15682812
55	MP0000716_abnormal_immune_system	1.11922555
56	MP0010234_abnormal_vibrissa_follicle	1.11878933
57	MP0002429_abnormal_blood_cell	1.09413562
58	MP0008260_abnormal_autophagy	1.09113141
59	MP0004381_abnormal_hair_follicle	1.08428843
60	MP0008007_abnormal_cellular_replicative	1.08351964
61	MP0003077_abnormal_cell_cycle	1.05644270
62	MP0001145_abnormal_male_reproductive	1.05502200
63	MP0010329_abnormal_lipoprotein_level	1.05336500
64	MP0002210_abnormal_sex_determination	1.05181032
65	MP0006054_spinal_hemorrhage	1.04838989
66	MP0003943_abnormal_hepatobiliary_system	1.04467316
67	MP0002452_abnormal_antigen_presenting	1.02987032
68	MP0005174_abnormal_tail_pigmentation	1.02575432
69	MP0002166_altered_tumor_susceptibility	1.01883612
70	MP0001944_abnormal_pancreas_morphology	0.99926955
71	MP0002405_respiratory_system_inflammati	0.99586531
72	MP0000609_abnormal_liver_physiology	0.98988646
73	MP0005389_reproductive_system_phenotype	0.98633523
74	MP0009785_altered_susceptibility_to	0.98536615
75	MP0001790_abnormal_immune_system	0.97512223
76	MP0005387_immune_system_phenotype	0.97512223
77	MP0003698_abnormal_male_reproductive	0.96488247
78	MP0003111_abnormal_nucleus_morphology	0.95914271
79	MP0000653_abnormal_sex_gland	0.95580693
80	MP0005085_abnormal_gallbladder_physiolo	0.95099149
81	MP0002138_abnormal_hepatobiliary_system	0.94991256
82	MP0000313_abnormal_cell_death	0.94387623
83	MP0008469_abnormal_protein_level	0.94330399
84	MP0000358_abnormal_cell_content/	0.94092306
85	MP0002693_abnormal_pancreas_physiology	0.93856573
86	MP0003122_maternal_imprinting	0.91926172
87	MP0002139_abnormal_hepatobiliary_system	0.91063328
88	MP0000598_abnormal_liver_morphology	0.90795074
89	MP0005000_abnormal_immune_tolerance	0.90209601
90	MP0002019_abnormal_tumor_incidence	0.89247089
91	MP0002127_abnormal_cardiovascular_syste	0.89244169
92	MP0009333_abnormal_splenocyte_physiolog	0.85643397
93	MP0008057_abnormal_DNA_replication	0.85305401
94	MP0002277_abnormal_respiratory_mucosa	0.85122831
95	MP0001986_abnormal_taste_sensitivity	0.79343256
96	MP0000465_gastrointestinal_hemorrhage	0.78304019
97	MP0009115_abnormal_fat_cell	0.76643304
98	MP0005319_abnormal_enzyme/_coenzyme	0.74581927
99	MP0005376_homeostasis/metabolism_phenot	0.73782704
100	MP0001984_abnormal_olfaction	0.71771418

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.31556027
2	Cutaneous melanoma (HP:0012056)	4.26204946
3	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	4.04334571
4	Panhypogammaglobulinemia (HP:0003139)	3.87736406
5	Microvesicular hepatic steatosis (HP:0001414)	3.39640956
6	Squamous cell carcinoma (HP:0002860)	3.26606292
7	Abnormality of DNA repair (HP:0003254)	3.12167442
8	Abnormal delayed hypersensitivity skin test (HP:0002963)	3.08884099
9	Dyschromatopsia (HP:0007641)	2.90043890
10	Neoplasm of the adrenal cortex (HP:0100641)	2.79591740
11	Stomatitis (HP:0010280)	2.71777909
12	Abnormality of fatty-acid metabolism (HP:0004359)	2.70666743
13	Poikiloderma (HP:0001029)	2.63099950
14	Hepatocellular necrosis (HP:0001404)	2.58130019
15	Acute hepatic failure (HP:0006554)	2.56726925
16	Ketosis (HP:0001946)	2.53732202
17	Brushfield spots (HP:0001088)	2.51194916
18	Prolonged bleeding time (HP:0003010)	2.50609649
19	True hermaphroditism (HP:0010459)	2.47374841
20	Recurrent abscess formation (HP:0002722)	2.47371832
21	Recurrent fungal infections (HP:0002841)	2.41092186
22	Reticulocytosis (HP:0001923)	2.39751727
23	Hypochromic microcytic anemia (HP:0004840)	2.37896963
24	Recurrent bacterial skin infections (HP:0005406)	2.32279806
25	Asymmetry of the thorax (HP:0001555)	2.32225807
26	Type 2 muscle fiber atrophy (HP:0003554)	2.31346962
27	Cheilitis (HP:0100825)	2.24592269
28	Recurrent gram-negative bacterial infections (HP:0005420)	2.24558487
29	Basal cell carcinoma (HP:0002671)	2.23665964
30	Hepatic necrosis (HP:0002605)	2.22896900
31	Hypochromic anemia (HP:0001931)	2.22590157
32	Thyroiditis (HP:0100646)	2.21973143
33	Severe combined immunodeficiency (HP:0004430)	2.21225605
34	Hypoplastic pelvis (HP:0008839)	2.21175357
35	Lipid accumulation in hepatocytes (HP:0006561)	2.18799270
36	Reduced antithrombin III activity (HP:0001976)	2.18684572
37	Renal Fanconi syndrome (HP:0001994)	2.14863600
38	Osteomalacia (HP:0002749)	2.13791215
39	Granulocytopenia (HP:0001913)	2.13595744
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.05849470
41	Recurrent cutaneous fungal infections (HP:0011370)	2.05043607
42	Chronic mucocutaneous candidiasis (HP:0002728)	2.05043607
43	Easy fatigability (HP:0003388)	2.04094706
44	Episodic fever (HP:0001954)	2.04052289
45	Abnormal ciliary motility (HP:0012262)	2.03743609
46	Recurrent skin infections (HP:0001581)	2.03324673
47	Cholelithiasis (HP:0001081)	1.99940455
48	Muscle fiber atrophy (HP:0100295)	1.98286912
49	Poor suck (HP:0002033)	1.93961037
50	Pancreatic islet-cell hyperplasia (HP:0004510)	1.92687310
51	Joint hemorrhage (HP:0005261)	1.91883726
52	Acute lymphatic leukemia (HP:0006721)	1.90913663
53	Abnormal gallbladder morphology (HP:0012437)	1.90896731
54	Spastic paraparesis (HP:0002313)	1.90629715
55	Increased CSF lactate (HP:0002490)	1.89491580
56	Obstructive lung disease (HP:0006536)	1.88346444
57	Chronic obstructive pulmonary disease (HP:0006510)	1.88346444
58	Elevated erythrocyte sedimentation rate (HP:0003565)	1.88255153
59	Absent thumb (HP:0009777)	1.87622124
60	Abnormality of endocrine pancreas physiology (HP:0012093)	1.87365297
61	Abnormality of the pancreatic islet cells (HP:0006476)	1.87365297
62	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.87107454
63	Abnormal gallbladder physiology (HP:0012438)	1.85301987
64	Cholecystitis (HP:0001082)	1.85301987
65	Increased serum lactate (HP:0002151)	1.85194080
66	Abnormality of T cell physiology (HP:0011840)	1.84491331
67	Mitochondrial inheritance (HP:0001427)	1.84255437
68	Fetal akinesia sequence (HP:0001989)	1.83499418
69	Ketoacidosis (HP:0001993)	1.83376271
70	Abnormality of pyrimidine metabolism (HP:0004353)	1.83213952
71	Microcytic anemia (HP:0001935)	1.82965132
72	Abnormality of reticulocytes (HP:0004312)	1.80218926
73	Pancreatic cysts (HP:0001737)	1.79894261
74	Large for gestational age (HP:0001520)	1.78660526
75	B lymphocytopenia (HP:0010976)	1.78655655
76	Gingival bleeding (HP:0000225)	1.76654485
77	Neutropenia (HP:0001875)	1.76514075
78	Abnormality of macrophages (HP:0004311)	1.76067545
79	Combined immunodeficiency (HP:0005387)	1.75623380
80	Abnormal sex determination (HP:0012244)	1.74720275
81	Sex reversal (HP:0012245)	1.74720275
82	Eosinophilia (HP:0001880)	1.74526502
83	Epiphyseal stippling (HP:0010655)	1.73459484
84	Gastrointestinal inflammation (HP:0004386)	1.72466609
85	Intestinal atresia (HP:0011100)	1.71211556
86	Progressive macrocephaly (HP:0004481)	1.70590135
87	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.70588131
88	Dicarboxylic aciduria (HP:0003215)	1.70588131
89	Hyperammonemia (HP:0001987)	1.70431344
90	Type I transferrin isoform profile (HP:0003642)	1.69030324
91	Popliteal pterygium (HP:0009756)	1.67786742
92	Abnormal glycosylation (HP:0012345)	1.67736518
93	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.67736518
94	Abnormal protein N-linked glycosylation (HP:0012347)	1.67736518
95	Abnormal protein glycosylation (HP:0012346)	1.67736518
96	Cutaneous photosensitivity (HP:0000992)	1.66013820
97	Abnormal rod and cone electroretinograms (HP:0008323)	1.65190154
98	Myelodysplasia (HP:0002863)	1.64844735
99	Abnormality of B cell number (HP:0010975)	1.64795629
100	Hypoproteinemia (HP:0003075)	1.64709679

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.05345901
2	PINK1	3.30292912
3	MAP4K2	3.24968590
4	EPHB1	3.06768935
5	TRIM28	2.89956991
6	TNK2	2.53995834
7	MAP4K1	2.53442510
8	FGFR2	2.29185211
9	EIF2AK3	1.90109360
10	MARK3	1.89308244
11	STK16	1.79788099
12	RIPK4	1.79174027
13	DYRK3	1.68456090
14	MAP2K3	1.63264394
15	BCKDK	1.61049515
16	ERN1	1.58791513
17	EIF2AK1	1.47314901
18	IRAK4	1.41803815
19	RAF1	1.41427496
20	NME2	1.41108617
21	FGFR3	1.36779013
22	BRAF	1.35930881
23	BTK	1.34552188
24	NLK	1.26651612
25	TYK2	1.19768135
26	ZAP70	1.15399584
27	SMG1	1.15155679
28	ZAK	1.11205598
29	PDK2	1.10858181
30	BLK	1.07361154
31	CCNB1	1.06011944
32	TLK1	1.05720679
33	KSR2	1.05418114
34	SYK	1.00623402
35	MST4	1.00239518
36	CSNK1G3	0.98769102
37	TAOK3	0.96592774
38	MAP3K10	0.95742833
39	WNK4	0.95719033
40	CSNK1A1L	0.93802044
41	GRK6	0.93779880
42	YES1	0.90726378
43	PKN2	0.90615083
44	KSR1	0.89533113
45	TEC	0.89113228
46	SIK3	0.86838644
47	NME1	0.85609787
48	ATR	0.85524449
49	HCK	0.85055415
50	CDK7	0.83854721
51	NUAK1	0.81881815
52	LYN	0.79853441
53	CSNK1G1	0.79260159
54	PIK3CG	0.79246181
55	PRKCI	0.78406155
56	CSF1R	0.77840539
57	GRK1	0.77446327
58	IKBKE	0.74024278
59	ACVR1B	0.73161087
60	BCR	0.72960648
61	PTK2B	0.70967332
62	MAP3K1	0.70669662
63	IKBKB	0.70257787
64	FGR	0.70124318
65	PRKCQ	0.68776100
66	PDK1	0.68491366
67	HIPK2	0.67057072
68	BMPR1B	0.65718876
69	PBK	0.63079229
70	BRSK2	0.62014160
71	PDPK1	0.61919361
72	RPS6KB1	0.60553906
73	TBK1	0.57270827
74	VRK2	0.55953354
75	NEK2	0.55670699
76	RPS6KA4	0.55354569
77	FES	0.55156516
78	CAMKK2	0.55140190
79	TNIK	0.54700325
80	MAP3K2	0.54131277
81	MAPKAPK2	0.51443148
82	IRAK2	0.50884073
83	BRSK1	0.50401000
84	CDK4	0.49559092
85	VRK1	0.48664198
86	RPS6KB2	0.47816526
87	RET	0.47231340
88	MELK	0.46201217
89	PIM2	0.45036122
90	MAP3K3	0.41320894
91	MAP3K8	0.40817081
92	JAK2	0.40053957
93	RPS6KA5	0.39990953
94	MAPK11	0.39472654
95	ATM	0.39042326
96	DYRK2	0.37898556
97	MKNK1	0.37354867
98	LCK	0.37198204
99	ITK	0.37181404
100	CDC42BPA	0.36387607

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.69461169
2	Base excision repair_Homo sapiens_hsa03410	2.80014769
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.57565633
4	Fanconi anemia pathway_Homo sapiens_hsa03460	2.51145394
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.44845304
6	Homologous recombination_Homo sapiens_hsa03440	2.34633010
7	Non-homologous end-joining_Homo sapiens_hsa03450	2.25346249
8	Sulfur relay system_Homo sapiens_hsa04122	2.06430884
9	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.96603783
10	Nucleotide excision repair_Homo sapiens_hsa03420	1.95376582
11	DNA replication_Homo sapiens_hsa03030	1.84577379
12	Other glycan degradation_Homo sapiens_hsa00511	1.80566208
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.79447937
14	Peroxisome_Homo sapiens_hsa04146	1.66058449
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.55845823
16	Propanoate metabolism_Homo sapiens_hsa00640	1.53444065
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52566757
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.48379704
19	Acute myeloid leukemia_Homo sapiens_hsa05221	1.41803571
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41504271
21	Butanoate metabolism_Homo sapiens_hsa00650	1.41061600
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.37877269
23	RNA degradation_Homo sapiens_hsa03018	1.36016299
24	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.35207020
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31965920
26	Basal transcription factors_Homo sapiens_hsa03022	1.30371086
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.29086309
28	mTOR signaling pathway_Homo sapiens_hsa04150	1.28749740
29	Folate biosynthesis_Homo sapiens_hsa00790	1.26108664
30	Non-small cell lung cancer_Homo sapiens_hsa05223	1.25058582
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.22175105
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.20270325
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18808686
34	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.16261810
35	RNA polymerase_Homo sapiens_hsa03020	1.09593936
36	One carbon pool by folate_Homo sapiens_hsa00670	1.05421984
37	Glutathione metabolism_Homo sapiens_hsa00480	1.02680372
38	Purine metabolism_Homo sapiens_hsa00230	1.02455423
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.00965627
40	Spliceosome_Homo sapiens_hsa03040	0.97769536
41	Regulation of autophagy_Homo sapiens_hsa04140	0.97416448
42	Endometrial cancer_Homo sapiens_hsa05213	0.95846831
43	RNA transport_Homo sapiens_hsa03013	0.95019143
44	Measles_Homo sapiens_hsa05162	0.93480193
45	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.93118955
46	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91033266
47	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.89723006
48	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.86926913
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.86682109
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.85046314
51	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.84965045
52	Mismatch repair_Homo sapiens_hsa03430	0.84841493
53	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.84621674
54	p53 signaling pathway_Homo sapiens_hsa04115	0.83787916
55	Metabolic pathways_Homo sapiens_hsa01100	0.82443171
56	Fatty acid metabolism_Homo sapiens_hsa01212	0.82232831
57	Complement and coagulation cascades_Homo sapiens_hsa04610	0.81962636
58	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.79433558
59	Herpes simplex infection_Homo sapiens_hsa05168	0.77248740
60	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.75907080
61	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.75246989
62	Osteoclast differentiation_Homo sapiens_hsa04380	0.74044353
63	Hepatitis B_Homo sapiens_hsa05161	0.72924352
64	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.72185873
65	Legionellosis_Homo sapiens_hsa05134	0.71189760
66	Pentose phosphate pathway_Homo sapiens_hsa00030	0.70992208
67	Fatty acid elongation_Homo sapiens_hsa00062	0.70335740
68	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68324475
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66306716
70	Viral carcinogenesis_Homo sapiens_hsa05203	0.65235494
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64617747
72	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.64054823
73	mRNA surveillance pathway_Homo sapiens_hsa03015	0.63943180
74	Thyroid cancer_Homo sapiens_hsa05216	0.63172262
75	Olfactory transduction_Homo sapiens_hsa04740	0.60103715
76	FoxO signaling pathway_Homo sapiens_hsa04068	0.59428894
77	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.58227213
78	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57929567
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.57201931
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.56990198
81	Fatty acid degradation_Homo sapiens_hsa00071	0.55555797
82	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.54100021
83	Retinol metabolism_Homo sapiens_hsa00830	0.52370486
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.51342657
85	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.51150163
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.50869644
87	Insulin resistance_Homo sapiens_hsa04931	0.50652908
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49743634
89	Protein export_Homo sapiens_hsa03060	0.49477531
90	Ribosome_Homo sapiens_hsa03010	0.47716496
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46961557
92	Linoleic acid metabolism_Homo sapiens_hsa00591	0.46581026
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46460847
94	Hepatitis C_Homo sapiens_hsa05160	0.45624181
95	Carbon metabolism_Homo sapiens_hsa01200	0.45509304
96	Pyruvate metabolism_Homo sapiens_hsa00620	0.45090807
97	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.43001992
98	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42307086
99	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.40435578
100	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.39182826

C14ORF93

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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