ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.52340885
2	response to pheromone (GO:0019236)	6.26360374
3	L-fucose catabolic process (GO:0042355)	4.82961915
4	fucose catabolic process (GO:0019317)	4.82961915
5	L-fucose metabolic process (GO:0042354)	4.82961915
6	kynurenine metabolic process (GO:0070189)	4.41142354
7	tryptophan catabolic process (GO:0006569)	4.36310192
8	indole-containing compound catabolic process (GO:0042436)	4.36310192
9	indolalkylamine catabolic process (GO:0046218)	4.36310192
10	regulation of hippo signaling (GO:0035330)	4.12505137
11	cellular ketone body metabolic process (GO:0046950)	3.99806194
12	indolalkylamine metabolic process (GO:0006586)	3.93422581
13	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.82648039
14	regulation of translation, ncRNA-mediated (GO:0045974)	3.82648039
15	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.82648039
16	positive regulation of CREB transcription factor activity (GO:0032793)	3.75900216
17	regulation of posttranscriptional gene silencing (GO:0060147)	3.71059043
18	regulation of gene silencing by miRNA (GO:0060964)	3.71059043
19	regulation of gene silencing by RNA (GO:0060966)	3.71059043
20	sulfation (GO:0051923)	3.63446497
21	tryptophan metabolic process (GO:0006568)	3.54738400
22	ketone body metabolic process (GO:1902224)	3.51735281
23	cellular response to ATP (GO:0071318)	3.45942916
24	protein import into peroxisome matrix (GO:0016558)	3.44913931
25	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.43227612
26	DNA deamination (GO:0045006)	3.38581996
27	indole-containing compound metabolic process (GO:0042430)	3.37688792
28	cellular response to exogenous dsRNA (GO:0071360)	3.36165558
29	primary amino compound metabolic process (GO:1901160)	3.36003732
30	histone-serine phosphorylation (GO:0035404)	3.28917867
31	NAD biosynthetic process (GO:0009435)	3.27820472
32	snRNA transcription (GO:0009301)	3.23041201
33	negative regulation of telomere maintenance (GO:0032205)	3.20794039
34	reciprocal DNA recombination (GO:0035825)	3.18721402
35	reciprocal meiotic recombination (GO:0007131)	3.18721402
36	serotonin metabolic process (GO:0042428)	3.18204490
37	oxidative demethylation (GO:0070989)	3.17391357
38	detection of light stimulus involved in sensory perception (GO:0050962)	3.12884104
39	detection of light stimulus involved in visual perception (GO:0050908)	3.12884104
40	endosome to melanosome transport (GO:0035646)	3.10103844
41	endosome to pigment granule transport (GO:0043485)	3.10103844
42	spinal cord motor neuron differentiation (GO:0021522)	3.10050820
43	nephron epithelium morphogenesis (GO:0072088)	3.08994149
44	nephron tubule morphogenesis (GO:0072078)	3.08994149
45	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.07625952
46	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.06581275
47	neuronal action potential (GO:0019228)	3.04300997
48	urinary tract smooth muscle contraction (GO:0014848)	3.01485142
49	gamma-aminobutyric acid transport (GO:0015812)	3.01314537
50	cornea development in camera-type eye (GO:0061303)	3.00533281
51	regulation of mesoderm development (GO:2000380)	2.98020971
52	interkinetic nuclear migration (GO:0022027)	2.97408477
53	fucosylation (GO:0036065)	2.97226269
54	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.86283009
55	cardiovascular system development (GO:0072358)	2.85107712
56	cellular biogenic amine catabolic process (GO:0042402)	2.84360753
57	amine catabolic process (GO:0009310)	2.84360753
58	negative regulation of sodium ion transport (GO:0010766)	2.83748893
59	regulation of histone phosphorylation (GO:0033127)	2.82345185
60	meiotic chromosome segregation (GO:0045132)	2.81594656
61	peristalsis (GO:0030432)	2.80395665
62	positive regulation of defense response to virus by host (GO:0002230)	2.79397808
63	respiratory chain complex IV assembly (GO:0008535)	2.79208924
64	regulation of action potential (GO:0098900)	2.79017636
65	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.77996217
66	nonmotile primary cilium assembly (GO:0035058)	2.77783351
67	cilium or flagellum-dependent cell motility (GO:0001539)	2.77432664
68	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.75489021
69	NADH dehydrogenase complex assembly (GO:0010257)	2.75489021
70	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.75489021
71	kidney morphogenesis (GO:0060993)	2.71983754
72	pericardium development (GO:0060039)	2.70753894
73	positive regulation of developmental pigmentation (GO:0048087)	2.69556930
74	rRNA catabolic process (GO:0016075)	2.69046599
75	reflex (GO:0060004)	2.68204506
76	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.66957151
77	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.66957151
78	signal peptide processing (GO:0006465)	2.65437368
79	piRNA metabolic process (GO:0034587)	2.64781896
80	cAMP catabolic process (GO:0006198)	2.64277306
81	neural tube formation (GO:0001841)	2.61114282
82	drug catabolic process (GO:0042737)	2.60054899
83	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.58317091
84	basic amino acid transport (GO:0015802)	2.57535006
85	protein K48-linked deubiquitination (GO:0071108)	2.57101371
86	behavioral response to ethanol (GO:0048149)	2.56664067
87	regulation of pigment cell differentiation (GO:0050932)	2.55368798
88	positive regulation of action potential (GO:0045760)	2.54014699
89	multicellular organism reproduction (GO:0032504)	2.52408224
90	positive regulation of fatty acid oxidation (GO:0046321)	2.50998050
91	flavonoid metabolic process (GO:0009812)	2.48818875
92	neurotransmitter metabolic process (GO:0042133)	2.48749933
93	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.47101380
94	synaptic transmission, cholinergic (GO:0007271)	2.46653293
95	positive regulation of protein kinase C signaling (GO:0090037)	2.46196517
96	motile cilium assembly (GO:0044458)	2.46153986
97	embryonic axis specification (GO:0000578)	2.44759764
98	recombinational repair (GO:0000725)	2.44191632
99	double-strand break repair via homologous recombination (GO:0000724)	2.44043530
100	positive regulation of fatty acid transport (GO:2000193)	2.43302537

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.64872398
2	VDR_22108803_ChIP-Seq_LS180_Human	3.22367290
3	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.14133686
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.11336930
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.68390545
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.44133084
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.43718707
8	DROSHA_22980978_ChIP-Seq_HELA_Human	1.99413572
9	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.97873939
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.91844696
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.91750454
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.79853051
13	ER_23166858_ChIP-Seq_MCF-7_Human	1.79668060
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.78333666
15	EWS_26573619_Chip-Seq_HEK293_Human	1.75996232
16	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65425199
17	AR_21572438_ChIP-Seq_LNCaP_Human	1.62212303
18	ERA_21632823_ChIP-Seq_H3396_Human	1.61500484
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60663175
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.56905607
21	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55022749
22	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55022749
23	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.54872013
24	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.53579863
25	STAT3_23295773_ChIP-Seq_U87_Human	1.48833688
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.44632223
27	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.43855929
28	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.42623802
29	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.40049452
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.39997775
31	BCAT_22108803_ChIP-Seq_LS180_Human	1.39265302
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38758694
33	HOXB7_26014856_ChIP-Seq_BT474_Human	1.38537360
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38035315
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36472838
36	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.35018618
37	TP53_16413492_ChIP-PET_HCT116_Human	1.33247475
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.33124024
39	TCF4_23295773_ChIP-Seq_U87_Human	1.30368939
40	P300_19829295_ChIP-Seq_ESCs_Human	1.29335732
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29077035
42	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.29040356
43	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.28283563
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26522977
45	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.25515454
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24886096
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24886096
48	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.24051778
49	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.23943306
50	OCT4_20526341_ChIP-Seq_ESCs_Human	1.22912527
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22557710
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22526084
53	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.22373371
54	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22207059
55	P53_21459846_ChIP-Seq_SAOS-2_Human	1.22138402
56	FUS_26573619_Chip-Seq_HEK293_Human	1.21698493
57	* AR_25329375_ChIP-Seq_VCAP_Human	1.21256745
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.20967224
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.20173787
60	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.18980213
61	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.18467530
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.17752244
63	TAF2_19829295_ChIP-Seq_ESCs_Human	1.17652699
64	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.17478273
65	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.16236084
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16134651
67	MYC_19829295_ChIP-Seq_ESCs_Human	1.15739331
68	NCOR_22424771_ChIP-Seq_293T_Human	1.13963376
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.12355207
70	IGF1R_20145208_ChIP-Seq_DFB_Human	1.10879390
71	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.10849700
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10211913
73	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10108692
74	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.08959449
75	AHR_22903824_ChIP-Seq_MCF-7_Human	1.08887402
76	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.08239472
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.07517103
78	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.05807325
79	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04474314
80	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04248181
81	NANOG_20526341_ChIP-Seq_ESCs_Human	1.03805963
82	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.03790925
83	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03254764
84	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03006251
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02204695
86	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01869288
87	E2F1_20622854_ChIP-Seq_HELA_Human	1.01594222
88	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.01004059
89	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00986346
90	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.00907676
91	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00864981
92	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00864981
93	TCF4_22108803_ChIP-Seq_LS180_Human	1.00705204
94	CBP_20019798_ChIP-Seq_JUKART_Human	1.00443609
95	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00443609
96	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00333733
97	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99880179
98	* AR_20517297_ChIP-Seq_VCAP_Human	0.99807667
99	* RAC3_21632823_ChIP-Seq_H3396_Human	0.96979447
100	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.95624785

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	3.96252343
2	MP0003195_calcinosis	3.55352442
3	MP0004043_abnormal_pH_regulation	3.13121671
4	MP0000569_abnormal_digit_pigmentation	2.96742636
5	MP0003646_muscle_fatigue	2.96407645
6	MP0001986_abnormal_taste_sensitivity	2.67961449
7	MP0005174_abnormal_tail_pigmentation	2.39923387
8	MP0005551_abnormal_eye_electrophysiolog	2.30752036
9	MP0001968_abnormal_touch/_nociception	2.20291516
10	MP0008875_abnormal_xenobiotic_pharmacok	2.14598427
11	MP0009046_muscle_twitch	2.03024705
12	MP0004142_abnormal_muscle_tone	2.01984755
13	MP0002653_abnormal_ependyma_morphology	2.00101289
14	MP0008872_abnormal_physiological_respon	1.98362324
15	MP0004130_abnormal_muscle_cell	1.97707555
16	MP0008961_abnormal_basal_metabolism	1.96463703
17	MP0002638_abnormal_pupillary_reflex	1.95092202
18	MP0009745_abnormal_behavioral_response	1.86919980
19	MP0000427_abnormal_hair_cycle	1.86715748
20	MP0004147_increased_porphyrin_level	1.83940022
21	MP0002876_abnormal_thyroid_physiology	1.76490865
22	MP0002102_abnormal_ear_morphology	1.76133793
23	MP0004133_heterotaxia	1.74978114
24	MP0008877_abnormal_DNA_methylation	1.70704145
25	MP0005171_absent_coat_pigmentation	1.68282758
26	MP0002938_white_spotting	1.60412329
27	MP0002735_abnormal_chemical_nociception	1.57972266
28	MP0001485_abnormal_pinna_reflex	1.55106661
29	MP0002736_abnormal_nociception_after	1.50985018
30	MP0000383_abnormal_hair_follicle	1.47222243
31	MP0002837_dystrophic_cardiac_calcinosis	1.46923635
32	MP0006292_abnormal_olfactory_placode	1.46050989
33	MP0004885_abnormal_endolymph	1.42546101
34	MP0005423_abnormal_somatic_nervous	1.42291871
35	MP0001873_stomach_inflammation	1.38928212
36	MP0004742_abnormal_vestibular_system	1.38165920
37	MP0005645_abnormal_hypothalamus_physiol	1.37358628
38	MP0001501_abnormal_sleep_pattern	1.37062107
39	MP0002064_seizures	1.36015693
40	MP0005253_abnormal_eye_physiology	1.30490565
41	MP0002928_abnormal_bile_duct	1.29812925
42	MP0002272_abnormal_nervous_system	1.28944265
43	MP0005448_abnormal_energy_balance	1.26661354
44	MP0004145_abnormal_muscle_electrophysio	1.24821876
45	MP0002572_abnormal_emotion/affect_behav	1.24231478
46	MP0000538_abnormal_urinary_bladder	1.23139131
47	MP0005377_hearing/vestibular/ear_phenot	1.17852942
48	MP0003878_abnormal_ear_physiology	1.17852942
49	MP0003890_abnormal_embryonic-extraembry	1.16590217
50	MP0002067_abnormal_sensory_capabilities	1.14856856
51	MP0004924_abnormal_behavior	1.13769427
52	MP0005386_behavior/neurological_phenoty	1.13769427
53	MP0005167_abnormal_blood-brain_barrier	1.13586403
54	MP0000631_abnormal_neuroendocrine_gland	1.12270624
55	MP0000230_abnormal_systemic_arterial	1.11828422
56	MP0010386_abnormal_urinary_bladder	1.11363656
57	MP0001970_abnormal_pain_threshold	1.11362727
58	MP0003283_abnormal_digestive_organ	1.11092429
59	MP0001502_abnormal_circadian_rhythm	1.09061899
60	MP0001486_abnormal_startle_reflex	1.08855347
61	MP0002160_abnormal_reproductive_system	1.06137893
62	MP0002733_abnormal_thermal_nociception	1.04932898
63	MP0003011_delayed_dark_adaptation	1.04887364
64	MP0005083_abnormal_biliary_tract	1.03947549
65	MP0002063_abnormal_learning/memory/cond	1.02508637
66	MP0010030_abnormal_orbit_morphology	1.02262072
67	MP0005085_abnormal_gallbladder_physiolo	1.02161630
68	MP0003137_abnormal_impulse_conducting	1.01812376
69	MP0005646_abnormal_pituitary_gland	1.00953577
70	MP0004381_abnormal_hair_follicle	1.00002763
71	MP0005195_abnormal_posterior_eye	0.98476714
72	MP0002557_abnormal_social/conspecific_i	0.97987704
73	MP0003119_abnormal_digestive_system	0.97720840
74	MP0001324_abnormal_eye_pigmentation	0.97496725
75	MP0000470_abnormal_stomach_morphology	0.96048127
76	MP0003718_maternal_effect	0.95621075
77	MP0006072_abnormal_retinal_apoptosis	0.94761755
78	MP0003635_abnormal_synaptic_transmissio	0.92552035
79	MP0010329_abnormal_lipoprotein_level	0.90990130
80	MP0000026_abnormal_inner_ear	0.89483571
81	MP0002277_abnormal_respiratory_mucosa	0.89095059
82	MP0001664_abnormal_digestion	0.88653253
83	MP0005389_reproductive_system_phenotype	0.87489474
84	MP0002095_abnormal_skin_pigmentation	0.85679804
85	MP0005266_abnormal_metabolism	0.85473872
86	MP0005365_abnormal_bile_salt	0.81600591
87	MP0005332_abnormal_amino_acid	0.81489340
88	MP0003045_fibrosis	0.79374763
89	MP0006276_abnormal_autonomic_nervous	0.78893962
90	MP0005410_abnormal_fertilization	0.78752744
91	MP0002933_joint_inflammation	0.77992525
92	MP0003698_abnormal_male_reproductive	0.77753860
93	MP0002752_abnormal_somatic_nervous	0.77227887
94	MP0003959_abnormal_lean_body	0.77085184
95	MP0003252_abnormal_bile_duct	0.76118330
96	MP0000778_abnormal_nervous_system	0.71155052
97	MP0002693_abnormal_pancreas_physiology	0.70926416
98	MP0001919_abnormal_reproductive_system	0.70176522
99	MP0002210_abnormal_sex_determination	0.69133855
100	MP0005670_abnormal_white_adipose	0.68733152

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.62817180
2	Birth length less than 3rd percentile (HP:0003561)	4.39415291
3	Molar tooth sign on MRI (HP:0002419)	4.37813122
4	Abnormality of midbrain morphology (HP:0002418)	4.37813122
5	Genetic anticipation (HP:0003743)	4.36503194
6	Congenital stationary night blindness (HP:0007642)	4.22888415
7	Pancreatic fibrosis (HP:0100732)	3.77014901
8	Abnormality of alanine metabolism (HP:0010916)	3.71998845
9	Hyperalaninemia (HP:0003348)	3.71998845
10	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.71998845
11	Nephronophthisis (HP:0000090)	3.70630184
12	True hermaphroditism (HP:0010459)	3.68488170
13	Patellar aplasia (HP:0006443)	3.47417195
14	Type II lissencephaly (HP:0007260)	3.45688353
15	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.44454353
16	Tubular atrophy (HP:0000092)	3.30042431
17	Attenuation of retinal blood vessels (HP:0007843)	3.28146192
18	Hyperventilation (HP:0002883)	3.24139214
19	Aplasia/Hypoplasia of the patella (HP:0006498)	3.24007866
20	Abnormality of the renal medulla (HP:0100957)	3.23621999
21	Clumsiness (HP:0002312)	3.18048938
22	Protruding tongue (HP:0010808)	3.16946561
23	Progressive cerebellar ataxia (HP:0002073)	3.12178647
24	Inability to walk (HP:0002540)	3.08762842
25	Decreased circulating renin level (HP:0003351)	3.08700499
26	Large for gestational age (HP:0001520)	3.08508240
27	Cerebellar dysplasia (HP:0007033)	3.07665292
28	Cystic liver disease (HP:0006706)	3.01486622
29	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.92932929
30	Chronic hepatic failure (HP:0100626)	2.91554967
31	Abnormality of the renal cortex (HP:0011035)	2.88166183
32	Concave nail (HP:0001598)	2.86890714
33	Breast hypoplasia (HP:0003187)	2.85973690
34	Hypoplasia of the pons (HP:0012110)	2.79338784
35	Abnormality of the pons (HP:0007361)	2.74709048
36	Abnormal drinking behavior (HP:0030082)	2.65099442
37	Polydipsia (HP:0001959)	2.65099442
38	Gaze-evoked nystagmus (HP:0000640)	2.59988915
39	Progressive inability to walk (HP:0002505)	2.54715582
40	Furrowed tongue (HP:0000221)	2.49191825
41	Pendular nystagmus (HP:0012043)	2.48814565
42	Duplicated collecting system (HP:0000081)	2.40961871
43	Chorioretinal atrophy (HP:0000533)	2.39598420
44	Abnormality of the renal collecting system (HP:0004742)	2.37684520
45	Partial agenesis of the corpus callosum (HP:0001338)	2.37463766
46	Congenital, generalized hypertrichosis (HP:0004540)	2.29172719
47	Medial flaring of the eyebrow (HP:0010747)	2.28093936
48	Severe muscular hypotonia (HP:0006829)	2.24751241
49	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.23811055
50	Lissencephaly (HP:0001339)	2.22433927
51	Abolished electroretinogram (ERG) (HP:0000550)	2.21747565
52	Absent/shortened dynein arms (HP:0200106)	2.21694255
53	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.21694255
54	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.18238463
55	Rib fusion (HP:0000902)	2.13454748
56	Congenital hepatic fibrosis (HP:0002612)	2.12516449
57	Sclerocornea (HP:0000647)	2.10466331
58	Broad-based gait (HP:0002136)	2.10464756
59	Polyuria (HP:0000103)	2.07807730
60	Increased cerebral lipofuscin (HP:0011813)	2.07070007
61	Decreased central vision (HP:0007663)	2.06669791
62	Anencephaly (HP:0002323)	2.06062637
63	Bile duct proliferation (HP:0001408)	2.00443620
64	Abnormal biliary tract physiology (HP:0012439)	2.00443620
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.96804220
66	Fair hair (HP:0002286)	1.95550409
67	Tachypnea (HP:0002789)	1.92534045
68	Male pseudohermaphroditism (HP:0000037)	1.91477095
69	Hypoplastic ischia (HP:0003175)	1.91179319
70	Amelogenesis imperfecta (HP:0000705)	1.87926007
71	Bulbous nose (HP:0000414)	1.87882676
72	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83001857
73	Congenital sensorineural hearing impairment (HP:0008527)	1.82355566
74	Hypoalbuminemia (HP:0003073)	1.82018277
75	Abnormal albumin level (HP:0012116)	1.82018277
76	Gait imbalance (HP:0002141)	1.81981888
77	Mesangial abnormality (HP:0001966)	1.81350611
78	Stomach cancer (HP:0012126)	1.81161812
79	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.80243597
80	Abnormality of DNA repair (HP:0003254)	1.78697993
81	Increased corneal curvature (HP:0100692)	1.75547625
82	Keratoconus (HP:0000563)	1.75547625
83	Abnormal number of erythroid precursors (HP:0012131)	1.74558153
84	Congenital primary aphakia (HP:0007707)	1.74023439
85	Abnormality of renin-angiotensin system (HP:0000847)	1.73022318
86	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.71631358
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.70778123
88	Absent thumb (HP:0009777)	1.70430610
89	Widely spaced teeth (HP:0000687)	1.69276427
90	Bilateral microphthalmos (HP:0007633)	1.69013844
91	Microretrognathia (HP:0000308)	1.68802792
92	Confusion (HP:0001289)	1.63248122
93	Small hand (HP:0200055)	1.63204571
94	Ectopic kidney (HP:0000086)	1.62291683
95	Febrile seizures (HP:0002373)	1.61698972
96	Abnormal urine output (HP:0012590)	1.60454468
97	Absent speech (HP:0001344)	1.59638493
98	Nephrogenic diabetes insipidus (HP:0009806)	1.59545382
99	Hypoplastic nipples (HP:0002557)	1.59059083
100	Macroglossia (HP:0000158)	1.58944317

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.28954739
2	ACVR1B	5.43489335
3	BMPR1B	4.60863699
4	TLK1	3.60246702
5	ADRBK2	3.51370837
6	WNK4	2.91648858
7	ZAK	2.87524875
8	MAPK15	2.69643527
9	TGFBR1	2.27441861
10	DAPK2	2.07055551
11	GRK1	1.95427196
12	INSRR	1.95056902
13	TAOK3	1.76697322
14	ADRBK1	1.71116171
15	SIK2	1.58237873
16	AKT3	1.39414578
17	MAPK13	1.33525543
18	WNK3	1.30669871
19	PINK1	1.24352752
20	MAP2K6	1.23897085
21	NEK2	1.22696086
22	MKNK2	1.17066904
23	CAMK1D	1.16779906
24	NTRK3	1.15080897
25	OXSR1	1.11819666
26	NUAK1	1.08090114
27	TXK	1.06014631
28	CASK	1.03757513
29	PIK3CA	1.02934566
30	PNCK	1.01904315
31	MAPKAPK3	1.01862929
32	CAMKK2	1.01434063
33	RPS6KA6	0.94605666
34	MELK	0.94534231
35	PTK2B	0.88234993
36	CHUK	0.87752922
37	TRPM7	0.82766692
38	STK39	0.80113212
39	CAMKK1	0.80073386
40	MAP4K2	0.79973531
41	TNK2	0.76529445
42	CAMK1G	0.76465688
43	IKBKB	0.76074897
44	MAP3K7	0.75164721
45	WNK1	0.70837412
46	MUSK	0.70460793
47	STK11	0.70227777
48	MAP2K1	0.69513350
49	RPS6KA5	0.67923695
50	PRKCG	0.65844348
51	PKN1	0.65528559
52	CAMK1	0.63583719
53	PRKAA1	0.62999411
54	TYRO3	0.62571660
55	STK38L	0.61873136
56	MAP3K4	0.60496105
57	PRKAA2	0.59102342
58	MAP2K2	0.59047649
59	PAK3	0.58201822
60	KIT	0.56243536
61	NME1	0.50984527
62	BRSK2	0.49710179
63	ERBB2	0.47786143
64	PRKCH	0.46740071
65	MAPK11	0.46370261
66	CHEK2	0.45736240
67	PRKCQ	0.45299972
68	BLK	0.45196479
69	PHKG2	0.44232327
70	PHKG1	0.44232327
71	MET	0.38523735
72	TNIK	0.38471867
73	TIE1	0.38434114
74	CAMK4	0.38126530
75	MAPKAPK5	0.37787111
76	IRAK1	0.37623593
77	ITK	0.36992414
78	NTRK2	0.36065641
79	MARK3	0.35954791
80	NLK	0.34992499
81	WEE1	0.34133657
82	MAP4K1	0.33232349
83	PRKCE	0.32373440
84	STK38	0.32200576
85	CAMK2A	0.31324275
86	DYRK2	0.30731788
87	TRIB3	0.30441008
88	CDC42BPA	0.29830493
89	PRKCZ	0.29692101
90	MAP2K4	0.29431804
91	PIM1	0.28939824
92	SYK	0.28694454
93	PRKACA	0.28395416
94	MARK1	0.28138186
95	OBSCN	0.27308308
96	PRKD2	0.26441986
97	TEC	0.26147054
98	FGFR2	0.25860934
99	SGK2	0.25827952
100	PIK3CG	0.24094485

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.03764963
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.02725046
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.89030482
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.86094874
5	Phototransduction_Homo sapiens_hsa04744	2.49142869
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.36657109
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.29920397
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.29487046
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.13432587
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.07901488
11	ABC transporters_Homo sapiens_hsa02010	2.02856732
12	Butanoate metabolism_Homo sapiens_hsa00650	2.02709969
13	Homologous recombination_Homo sapiens_hsa03440	2.01880881
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.01397014
15	Nicotine addiction_Homo sapiens_hsa05033	1.99624328
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.81090706
17	Sulfur relay system_Homo sapiens_hsa04122	1.80726201
18	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74108895
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.71411851
20	Taste transduction_Homo sapiens_hsa04742	1.68766076
21	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67073695
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61848606
23	Caffeine metabolism_Homo sapiens_hsa00232	1.60213876
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.58946054
25	RNA polymerase_Homo sapiens_hsa03020	1.58332681
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55727814
27	Histidine metabolism_Homo sapiens_hsa00340	1.43939879
28	Morphine addiction_Homo sapiens_hsa05032	1.39183413
29	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29494881
30	Olfactory transduction_Homo sapiens_hsa04740	1.22466397
31	Basal transcription factors_Homo sapiens_hsa03022	1.21211714
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.19287265
33	Glycerolipid metabolism_Homo sapiens_hsa00561	1.17304726
34	Calcium signaling pathway_Homo sapiens_hsa04020	1.09135065
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08537007
36	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06783615
37	Circadian entrainment_Homo sapiens_hsa04713	1.05798155
38	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04849428
39	Lysine degradation_Homo sapiens_hsa00310	1.04313779
40	Insulin secretion_Homo sapiens_hsa04911	1.02851978
41	Serotonergic synapse_Homo sapiens_hsa04726	1.02499271
42	Glutamatergic synapse_Homo sapiens_hsa04724	1.00692347
43	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.99960687
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.99814184
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97517382
46	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97451878
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.94686310
48	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.85988489
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.84728151
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.83533144
51	One carbon pool by folate_Homo sapiens_hsa00670	0.83005765
52	Oxidative phosphorylation_Homo sapiens_hsa00190	0.77842708
53	GABAergic synapse_Homo sapiens_hsa04727	0.76281282
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.75014158
55	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.72588749
56	Peroxisome_Homo sapiens_hsa04146	0.71113177
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.70512568
58	Retinol metabolism_Homo sapiens_hsa00830	0.70309271
59	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.67930023
60	Mineral absorption_Homo sapiens_hsa04978	0.67647521
61	Cholinergic synapse_Homo sapiens_hsa04725	0.66866452
62	Circadian rhythm_Homo sapiens_hsa04710	0.64926468
63	Salivary secretion_Homo sapiens_hsa04970	0.61874735
64	Regulation of autophagy_Homo sapiens_hsa04140	0.60122442
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.59683715
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.58161902
67	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57165634
68	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.56412547
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.55630763
70	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.55242649
71	Pancreatic secretion_Homo sapiens_hsa04972	0.54195560
72	Cocaine addiction_Homo sapiens_hsa05030	0.52881996
73	RNA degradation_Homo sapiens_hsa03018	0.52080718
74	Long-term depression_Homo sapiens_hsa04730	0.51556071
75	Graft-versus-host disease_Homo sapiens_hsa05332	0.51210802
76	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50714255
77	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50672889
78	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.50623173
79	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.50160257
80	Basal cell carcinoma_Homo sapiens_hsa05217	0.48749304
81	Asthma_Homo sapiens_hsa05310	0.47159608
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.46486244
83	Gastric acid secretion_Homo sapiens_hsa04971	0.45830203
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.44841391
85	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.44728311
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.44409824
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43907979
88	Huntingtons disease_Homo sapiens_hsa05016	0.43842049
89	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43502193
90	Bile secretion_Homo sapiens_hsa04976	0.42602388
91	MAPK signaling pathway_Homo sapiens_hsa04010	0.41136151
92	Dopaminergic synapse_Homo sapiens_hsa04728	0.37843445
93	Purine metabolism_Homo sapiens_hsa00230	0.35151952
94	Pyrimidine metabolism_Homo sapiens_hsa00240	0.32230553
95	Type II diabetes mellitus_Homo sapiens_hsa04930	0.31417856
96	Parkinsons disease_Homo sapiens_hsa05012	0.31257725
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.30443059
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.30060429
99	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.28724249
100	Metabolic pathways_Homo sapiens_hsa01100	0.28154473

C15ORF40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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