ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	4.35780236
2	sarcomere organization (GO:0045214)	4.02288012
3	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.98122752
4	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.92311448
5	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.67681320
6	regulation of relaxation of muscle (GO:1901077)	3.66704251
7	regulation of cell communication by electrical coupling (GO:0010649)	3.62346165
8	behavioral response to nicotine (GO:0035095)	3.53692851
9	cardiac myofibril assembly (GO:0055003)	3.46020130
10	regulation of actin filament-based movement (GO:1903115)	3.41335619
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.36158722
12	NADH dehydrogenase complex assembly (GO:0010257)	3.36158722
13	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.36158722
14	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.34970966
15	detection of calcium ion (GO:0005513)	3.32549079
16	cellular ketone body metabolic process (GO:0046950)	3.31756901
17	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	3.28973091
18	adult heart development (GO:0007512)	3.24935092
19	positive regulation of action potential (GO:0045760)	3.23124431
20	otic vesicle formation (GO:0030916)	3.19599819
21	cardiac muscle cell development (GO:0055013)	3.17623750
22	regulation of membrane repolarization (GO:0060306)	3.12919615
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.12790192
24	protein complex biogenesis (GO:0070271)	3.12097504
25	regulation of action potential (GO:0098900)	3.09529407
26	cardiac muscle hypertrophy (GO:0003300)	3.07509721
27	response to caffeine (GO:0031000)	3.07363519
28	myofibril assembly (GO:0030239)	3.07335908
29	actin-myosin filament sliding (GO:0033275)	3.05808551
30	muscle filament sliding (GO:0030049)	3.05808551
31	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.05434285
32	cardiac muscle contraction (GO:0060048)	3.00539277
33	ketone body metabolic process (GO:1902224)	2.97038804
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.94661400
35	ventricular cardiac muscle cell action potential (GO:0086005)	2.93521640
36	positive regulation of heart rate (GO:0010460)	2.92615982
37	striated muscle hypertrophy (GO:0014897)	2.90148529
38	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	2.90142039
39	cardiac muscle cell action potential (GO:0086001)	2.87734194
40	positive regulation of mitochondrial fission (GO:0090141)	2.86343011
41	positive regulation of cardiac muscle cell differentiation (GO:2000727)	2.85627988
42	heart contraction (GO:0060047)	2.84381635
43	heart process (GO:0003015)	2.84381635
44	mitochondrial respiratory chain complex assembly (GO:0033108)	2.84350931
45	cardiac cell development (GO:0055006)	2.84205617
46	ubiquinone biosynthetic process (GO:0006744)	2.82721489
47	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.82699994
48	cardiac muscle tissue morphogenesis (GO:0055008)	2.80504451
49	presynaptic membrane assembly (GO:0097105)	2.79801221
50	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.78268579
51	nonmotile primary cilium assembly (GO:0035058)	2.75311723
52	ubiquinone metabolic process (GO:0006743)	2.74860083
53	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	2.73323209
54	aspartate family amino acid catabolic process (GO:0009068)	2.71833800
55	regulation of heart rate (GO:0002027)	2.70179627
56	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.69459771
57	regulation of striated muscle contraction (GO:0006942)	2.65717956
58	actin-mediated cell contraction (GO:0070252)	2.64690064
59	somite development (GO:0061053)	2.63849772
60	response to pheromone (GO:0019236)	2.63814226
61	regulation of cardiac muscle cell contraction (GO:0086004)	2.62825347
62	cullin deneddylation (GO:0010388)	2.62556774
63	action potential (GO:0001508)	2.61760550
64	protein-cofactor linkage (GO:0018065)	2.61202600
65	pyrimidine nucleobase catabolic process (GO:0006208)	2.58617390
66	neuronal action potential (GO:0019228)	2.58369893
67	muscle tissue morphogenesis (GO:0060415)	2.57557931
68	cell communication involved in cardiac conduction (GO:0086065)	2.57382931
69	presynaptic membrane organization (GO:0097090)	2.56563681
70	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.55199267
71	regulation of sarcomere organization (GO:0060297)	2.54343733
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.52423765
73	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.52096967
74	replication fork processing (GO:0031297)	2.51875893
75	sulfation (GO:0051923)	2.50610344
76	regulation of the force of heart contraction (GO:0002026)	2.50599528
77	relaxation of cardiac muscle (GO:0055119)	2.49743508
78	cornea development in camera-type eye (GO:0061303)	2.49416218
79	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.48901646
80	regulation of sequestering of triglyceride (GO:0010889)	2.48742093
81	response to inactivity (GO:0014854)	2.48302551
82	negative regulation of heart rate (GO:0010459)	2.48253933
83	respiratory chain complex IV assembly (GO:0008535)	2.47796381
84	protein localization to cilium (GO:0061512)	2.47516906
85	DNA double-strand break processing (GO:0000729)	2.47392771
86	muscle hypertrophy (GO:0014896)	2.47108869
87	cardiac chamber formation (GO:0003207)	2.45819855
88	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.43178710
89	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.41711780
90	ATP synthesis coupled proton transport (GO:0015986)	2.41711780
91	protein polyglutamylation (GO:0018095)	2.41236158
92	actomyosin structure organization (GO:0031032)	2.39717745
93	cardiac ventricle formation (GO:0003211)	2.38630602
94	respiratory electron transport chain (GO:0022904)	2.38267815
95	kynurenine metabolic process (GO:0070189)	2.38234206
96	retinal ganglion cell axon guidance (GO:0031290)	2.37401176
97	regulation of skeletal muscle contraction (GO:0014819)	2.36834041
98	electron transport chain (GO:0022900)	2.36789036
99	cell proliferation in forebrain (GO:0021846)	2.36490368
100	regulation of cardiac muscle contraction (GO:0055117)	2.36485870

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.51145906
2	VDR_22108803_ChIP-Seq_LS180_Human	3.20631022
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.17283617
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.07596339
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.79284947
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.58671169
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.54656543
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.49539572
9	FUS_26573619_Chip-Seq_HEK293_Human	2.47695187
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46010597
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.42804187
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.37603419
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.21091743
14	EWS_26573619_Chip-Seq_HEK293_Human	2.19798590
15	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.16732270
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.14634650
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13238688
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.05552474
19	* P300_19829295_ChIP-Seq_ESCs_Human	2.02714443
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91875245
21	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.84023613
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.79522109
23	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.76988802
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.75183034
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.73341421
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.70863840
27	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.69158108
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68709838
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.62886669
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60111548
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59537903
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.58222220
33	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56703823
34	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54547581
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.54115349
36	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.54026233
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.53165324
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.53149640
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.51962059
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.49499129
41	* STAT3_23295773_ChIP-Seq_U87_Human	1.47884811
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.46906608
43	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.46738348
44	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45264466
45	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45040479
46	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.44047766
47	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.44031811
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43962333
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.43620582
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38815881
51	* NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.38222554
52	* TCF4_23295773_ChIP-Seq_U87_Human	1.38057610
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.37409972
54	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.36740155
55	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.36166833
56	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.32914244
57	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32752582
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30933400
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27626816
60	AR_25329375_ChIP-Seq_VCAP_Human	1.26808869
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.24852481
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24035747
63	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23134503
64	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22264389
65	* CBP_20019798_ChIP-Seq_JUKART_Human	1.19388475
66	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19388475
67	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.16549221
68	* TCF4_22108803_ChIP-Seq_LS180_Human	1.15960537
69	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15634484
70	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.15454650
71	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.13463235
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.13429338
73	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.12633400
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12207930
75	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.12019533
76	TP53_22573176_ChIP-Seq_HFKS_Human	1.11900092
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11739437
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.11532155
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10404202
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10404202
81	MYC_18940864_ChIP-ChIP_HL60_Human	1.08147222
82	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07628018
83	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07047743
84	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.04827581
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.04161496
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04161496
87	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.02061556
88	SOX9_26525672_Chip-Seq_HEART_Mouse	1.01769100
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00606374
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.99667342
91	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99374012
92	* SOX2_21211035_ChIP-Seq_LN229_Gbm	0.99159562
93	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98670992
94	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.97326850
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96939625
96	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.96466572
97	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.95967522
98	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.95595672
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94349497
100	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94084230

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.98889724
2	MP0004215_abnormal_myocardial_fiber	3.65688602
3	MP0004084_abnormal_cardiac_muscle	3.38167793
4	MP0003646_muscle_fatigue	2.99070623
5	MP0004145_abnormal_muscle_electrophysio	2.54714460
6	MP0008775_abnormal_heart_ventricle	2.37890598
7	MP0000751_myopathy	2.24484897
8	MP0006292_abnormal_olfactory_placode	2.19823580
9	MP0002102_abnormal_ear_morphology	2.11042573
10	MP0003137_abnormal_impulse_conducting	2.08736423
11	MP0004036_abnormal_muscle_relaxation	1.95088338
12	MP0008877_abnormal_DNA_methylation	1.89109877
13	MP0004484_altered_response_of	1.84551857
14	MP0005670_abnormal_white_adipose	1.77950879
15	MP0002972_abnormal_cardiac_muscle	1.73169269
16	MP0006072_abnormal_retinal_apoptosis	1.72898300
17	MP0005330_cardiomyopathy	1.71458902
18	MP0001984_abnormal_olfaction	1.63411295
19	MP0004085_abnormal_heartbeat	1.63187682
20	MP0005620_abnormal_muscle_contractility	1.58059511
21	MP0005551_abnormal_eye_electrophysiolog	1.55813544
22	MP0000749_muscle_degeneration	1.53865309
23	MP0001529_abnormal_vocalization	1.53420511
24	MP0002160_abnormal_reproductive_system	1.52580610
25	MP0002127_abnormal_cardiovascular_syste	1.43678615
26	MP0000631_abnormal_neuroendocrine_gland	1.40323082
27	MP0001485_abnormal_pinna_reflex	1.39905350
28	MP0002234_abnormal_pharynx_morphology	1.39411162
29	MP0009046_muscle_twitch	1.39083743
30	MP0001544_abnormal_cardiovascular_syste	1.38541973
31	MP0005385_cardiovascular_system_phenoty	1.38541973
32	MP0003567_abnormal_fetal_cardiomyocyte	1.38031550
33	MP0003880_abnormal_central_pattern	1.35259917
34	MP0005253_abnormal_eye_physiology	1.33551542
35	MP0000049_abnormal_middle_ear	1.28708040
36	MP0005646_abnormal_pituitary_gland	1.27523656
37	MP0005645_abnormal_hypothalamus_physiol	1.27140855
38	MP0004885_abnormal_endolymph	1.27027093
39	MP0002272_abnormal_nervous_system	1.26221785
40	MP0003787_abnormal_imprinting	1.25797082
41	MP0004133_heterotaxia	1.25778677
42	MP0006276_abnormal_autonomic_nervous	1.24411096
43	MP0009745_abnormal_behavioral_response	1.23807363
44	MP0000372_irregular_coat_pigmentation	1.23408863
45	MP0000569_abnormal_digit_pigmentation	1.21878230
46	MP0004142_abnormal_muscle_tone	1.21692569
47	MP0001968_abnormal_touch/_nociception	1.21664462
48	MP0002735_abnormal_chemical_nociception	1.19450386
49	MP0002106_abnormal_muscle_physiology	1.18782196
50	MP0002938_white_spotting	1.17064971
51	MP0001486_abnormal_startle_reflex	1.16088480
52	MP0005423_abnormal_somatic_nervous	1.15893923
53	MP0008058_abnormal_DNA_repair	1.15464224
54	MP0005187_abnormal_penis_morphology	1.15135333
55	MP0003937_abnormal_limbs/digits/tail_de	1.15042327
56	MP0005386_behavior/neurological_phenoty	1.11861319
57	MP0004924_abnormal_behavior	1.11861319
58	MP0003195_calcinosis	1.10317560
59	MP0003136_yellow_coat_color	1.08528118
60	MP0004130_abnormal_muscle_cell	1.08100025
61	MP0005389_reproductive_system_phenotype	1.05706395
62	MP0005369_muscle_phenotype	1.04102485
63	MP0002736_abnormal_nociception_after	1.03456103
64	MP0002638_abnormal_pupillary_reflex	1.03308790
65	MP0008789_abnormal_olfactory_epithelium	1.02400419
66	MP0006138_congestive_heart_failure	0.94218778
67	MP0002751_abnormal_autonomic_nervous	0.94101427
68	MP0001986_abnormal_taste_sensitivity	0.93761475
69	MP0003890_abnormal_embryonic-extraembry	0.93654674
70	MP0004087_abnormal_muscle_fiber	0.93598876
71	MP0000778_abnormal_nervous_system	0.92477431
72	MP0003121_genomic_imprinting	0.90595676
73	MP0000750_abnormal_muscle_regeneration	0.90148056
74	MP0003718_maternal_effect	0.88785739
75	MP0008872_abnormal_physiological_respon	0.85697908
76	MP0000427_abnormal_hair_cycle	0.85240033
77	MP0003119_abnormal_digestive_system	0.83009267
78	MP0006036_abnormal_mitochondrial_physio	0.81537565
79	MP0001293_anophthalmia	0.80920712
80	MP0010368_abnormal_lymphatic_system	0.80552461
81	MP0002557_abnormal_social/conspecific_i	0.80304315
82	MP0009697_abnormal_copulation	0.79783584
83	MP0005266_abnormal_metabolism	0.79364914
84	MP0002269_muscular_atrophy	0.78643720
85	MP0001661_extended_life_span	0.78627332
86	MP0003950_abnormal_plasma_membrane	0.76642614
87	MP0010630_abnormal_cardiac_muscle	0.76612804
88	MP0002752_abnormal_somatic_nervous	0.76272448
89	MP0002572_abnormal_emotion/affect_behav	0.76156225
90	MP0002064_seizures	0.76046067
91	MP0002653_abnormal_ependyma_morphology	0.75888547
92	MP0005195_abnormal_posterior_eye	0.75205295
93	MP0002822_catalepsy	0.71797430
94	MP0000026_abnormal_inner_ear	0.71312498
95	MP0002067_abnormal_sensory_capabilities	0.71161324
96	MP0002928_abnormal_bile_duct	0.70935691
97	MP0006035_abnormal_mitochondrial_morpho	0.70565887
98	MP0003635_abnormal_synaptic_transmissio	0.68321137
99	MP0005084_abnormal_gallbladder_morpholo	0.67592222
100	MP0009250_abnormal_appendicular_skeleto	0.66599654

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sudden death (HP:0001699)	4.09902898
2	Bundle branch block (HP:0011710)	3.76459165
3	Atrial fibrillation (HP:0005110)	3.59904466
4	Pancreatic cysts (HP:0001737)	3.56325759
5	Pancreatic fibrosis (HP:0100732)	3.51048467
6	Syncope (HP:0001279)	3.38576581
7	True hermaphroditism (HP:0010459)	3.36376988
8	Primary atrial arrhythmia (HP:0001692)	3.29005017
9	Supraventricular tachycardia (HP:0004755)	3.17459623
10	Supraventricular arrhythmia (HP:0005115)	3.05080615
11	Calf muscle hypertrophy (HP:0008981)	3.02605684
12	Abnormality of the calf musculature (HP:0001430)	3.02258179
13	Nephronophthisis (HP:0000090)	2.96112819
14	Molar tooth sign on MRI (HP:0002419)	2.85346907
15	Abnormality of midbrain morphology (HP:0002418)	2.85346907
16	Muscle hypertrophy of the lower extremities (HP:0008968)	2.84313098
17	Acute necrotizing encephalopathy (HP:0006965)	2.79094178
18	Left ventricular hypertrophy (HP:0001712)	2.68128462
19	Medial flaring of the eyebrow (HP:0010747)	2.64873198
20	Ventricular tachycardia (HP:0004756)	2.60967529
21	Methylmalonic acidemia (HP:0002912)	2.60921357
22	Lipoatrophy (HP:0100578)	2.58458868
23	Abnormality of the renal cortex (HP:0011035)	2.52999245
24	Mitochondrial inheritance (HP:0001427)	2.52686310
25	Progressive macrocephaly (HP:0004481)	2.51909818
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.51132376
27	Increased CSF lactate (HP:0002490)	2.47532600
28	Abnormality of the renal medulla (HP:0100957)	2.45723701
29	Hepatic necrosis (HP:0002605)	2.32897457
30	Acute encephalopathy (HP:0006846)	2.30645016
31	Renal cortical cysts (HP:0000803)	2.29550347
32	Palpitations (HP:0001962)	2.29475121
33	Abnormality of the labia minora (HP:0012880)	2.25765489
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.25234806
35	Congenital stationary night blindness (HP:0007642)	2.22482126
36	Hepatocellular necrosis (HP:0001404)	2.21656720
37	Ventricular arrhythmia (HP:0004308)	2.19824670
38	Gait imbalance (HP:0002141)	2.19758532
39	Congenital primary aphakia (HP:0007707)	2.17734634
40	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15924921
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.10816807
42	Abnormality of alanine metabolism (HP:0010916)	2.10816807
43	Hyperalaninemia (HP:0003348)	2.10816807
44	Genital tract atresia (HP:0001827)	2.10335548
45	Sclerocornea (HP:0000647)	2.09968820
46	Right ventricular cardiomyopathy (HP:0011663)	2.08592288
47	Type II lissencephaly (HP:0007260)	2.08198217
48	Furrowed tongue (HP:0000221)	2.05193050
49	Short tibia (HP:0005736)	2.05126771
50	Methylmalonic aciduria (HP:0012120)	2.04480765
51	Vaginal atresia (HP:0000148)	2.04317415
52	Dilated cardiomyopathy (HP:0001644)	2.04311222
53	Chronic hepatic failure (HP:0100626)	2.03561650
54	Heart block (HP:0012722)	2.02251326
55	Genetic anticipation (HP:0003743)	2.01027046
56	Hyperventilation (HP:0002883)	2.00068179
57	Cystic liver disease (HP:0006706)	1.98638386
58	Anencephaly (HP:0002323)	1.97870466
59	Nephrogenic diabetes insipidus (HP:0009806)	1.96741946
60	Increased hepatocellular lipid droplets (HP:0006565)	1.94268929
61	Hyperglycinemia (HP:0002154)	1.92572721
62	Gaze-evoked nystagmus (HP:0000640)	1.91282737
63	Tubular atrophy (HP:0000092)	1.90444657
64	Pendular nystagmus (HP:0012043)	1.90154553
65	Lipid accumulation in hepatocytes (HP:0006561)	1.88000755
66	Hyporeflexia of lower limbs (HP:0002600)	1.86366773
67	Small hand (HP:0200055)	1.85313844
68	Morphological abnormality of the middle ear (HP:0008609)	1.83473041
69	Broad-based gait (HP:0002136)	1.83463980
70	Increased serum lactate (HP:0002151)	1.82947209
71	Male pseudohermaphroditism (HP:0000037)	1.82649581
72	Abolished electroretinogram (ERG) (HP:0000550)	1.82241389
73	Cerebral edema (HP:0002181)	1.81980501
74	Optic nerve hypoplasia (HP:0000609)	1.81437686
75	Stenosis of the external auditory canal (HP:0000402)	1.80273801
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79859365
77	Optic disc pallor (HP:0000543)	1.79684093
78	Progressive cerebellar ataxia (HP:0002073)	1.77948367
79	Lactic acidosis (HP:0003128)	1.76378793
80	Abnormality of urine glucose concentration (HP:0011016)	1.75583123
81	Glycosuria (HP:0003076)	1.75583123
82	Postaxial foot polydactyly (HP:0001830)	1.74718238
83	Rimmed vacuoles (HP:0003805)	1.74708503
84	Attenuation of retinal blood vessels (HP:0007843)	1.71837878
85	Subaortic stenosis (HP:0001682)	1.71260825
86	Abnormality of the left ventricular outflow tract (HP:0011103)	1.71260825
87	Ventricular fibrillation (HP:0001663)	1.70341184
88	Postaxial hand polydactyly (HP:0001162)	1.70293165
89	Hypoplasia of the uterus (HP:0000013)	1.69044694
90	Bile duct proliferation (HP:0001408)	1.67924476
91	Abnormal biliary tract physiology (HP:0012439)	1.67924476
92	Pachygyria (HP:0001302)	1.67327978
93	Supernumerary spleens (HP:0009799)	1.67182809
94	Prolonged QT interval (HP:0001657)	1.66955222
95	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.66599408
96	Abnormal atrioventricular conduction (HP:0005150)	1.65923683
97	Colon cancer (HP:0003003)	1.65539854
98	Hypothermia (HP:0002045)	1.65158356
99	Abnormality of the renal collecting system (HP:0004742)	1.64641971
100	Abnormal EKG (HP:0003115)	1.62838681

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.34023402
2	OBSCN	2.84048752
3	MAP4K2	2.68812271
4	MYLK	2.63720235
5	MAP3K4	2.29173128
6	CASK	2.18018074
7	PINK1	2.11091922
8	MARK1	2.09015640
9	ZAK	2.05222628
10	PAK3	1.98773349
11	WNK3	1.93840304
12	BMPR1B	1.92733506
13	TNIK	1.86911491
14	ADRBK2	1.82633489
15	GRK1	1.79508438
16	NUAK1	1.71824342
17	BCKDK	1.58947912
18	LIMK1	1.49648997
19	MAPK13	1.46261454
20	TRIM28	1.43586672
21	MAP2K7	1.42000531
22	DMPK	1.40203321
23	PRKCE	1.39390235
24	WNK4	1.39156149
25	INSRR	1.38518513
26	MKNK2	1.34025909
27	DYRK2	1.29561357
28	STK39	1.28501277
29	PLK2	1.27334721
30	GRK7	1.25100320
31	BRSK2	1.22800381
32	ERBB3	1.20872060
33	FLT3	1.17343719
34	STK38L	1.08978460
35	OXSR1	1.07977475
36	PLK4	1.07255164
37	EPHA3	1.02382528
38	PHKG2	1.00746450
39	PHKG1	1.00746450
40	BCR	0.98689174
41	PDK2	0.95525704
42	ACVR1B	0.94418993
43	CAMK2D	0.94334171
44	TIE1	0.91250254
45	PLK3	0.90150598
46	PIK3CA	0.89820383
47	PNCK	0.89354452
48	MUSK	0.89063634
49	VRK1	0.87679659
50	CAMK2A	0.87641267
51	FGFR2	0.85587784
52	STK16	0.84414450
53	STK4	0.83989877
54	NEK1	0.83850682
55	NEK9	0.83713720
56	CSNK1G1	0.80313116
57	EIF2AK3	0.78463149
58	ADRBK1	0.78148382
59	VRK2	0.75186668
60	BUB1	0.74747410
61	CSNK1G3	0.74517866
62	CSNK1G2	0.73282106
63	MKNK1	0.70457360
64	PLK1	0.69563084
65	CSNK1A1L	0.68615249
66	CAMK1	0.68503893
67	PKN1	0.68130676
68	MST4	0.67458119
69	TAF1	0.66981880
70	PRKACA	0.63293539
71	PRKCG	0.62151525
72	TTN	0.61716948
73	PRKAA1	0.60307522
74	TLK1	0.60277435
75	CDC7	0.59002258
76	STK3	0.56202979
77	WEE1	0.55967693
78	LATS1	0.55961752
79	NTRK3	0.55869924
80	TGFBR1	0.53172287
81	ROCK1	0.51262655
82	DYRK3	0.51022930
83	CDK19	0.50544356
84	CAMK2B	0.47877557
85	TRPM7	0.46191354
86	EPHA4	0.44541885
87	FER	0.43968247
88	PRKAA2	0.42909702
89	NTRK2	0.41956629
90	NEK2	0.41862966
91	DYRK1A	0.41173055
92	SGK2	0.39066142
93	PRKG1	0.38466376
94	CAMK4	0.38160524
95	SRPK1	0.36727246
96	ATM	0.36673156
97	PRKACG	0.36580912
98	ATR	0.34232170
99	RPS6KA5	0.33656387
100	NLK	0.32661825

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.12464450
2	Cardiac muscle contraction_Homo sapiens_hsa04260	3.02287190
3	Oxidative phosphorylation_Homo sapiens_hsa00190	2.75955075
4	Parkinsons disease_Homo sapiens_hsa05012	2.50205530
5	Propanoate metabolism_Homo sapiens_hsa00640	2.44167935
6	Phototransduction_Homo sapiens_hsa04744	2.24324565
7	Butanoate metabolism_Homo sapiens_hsa00650	2.18150210
8	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.10688198
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.10061654
10	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.99009543
11	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.91966034
12	Huntingtons disease_Homo sapiens_hsa05016	1.68112898
13	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.65994190
14	Protein export_Homo sapiens_hsa03060	1.65559496
15	Alzheimers disease_Homo sapiens_hsa05010	1.63763244
16	Nicotine addiction_Homo sapiens_hsa05033	1.59921771
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.57612546
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.50792387
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.47138167
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42307847
21	RNA polymerase_Homo sapiens_hsa03020	1.41159299
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40713638
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38053348
24	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.36143424
25	Homologous recombination_Homo sapiens_hsa03440	1.26015295
26	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.25814794
27	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.25742481
28	Taste transduction_Homo sapiens_hsa04742	1.25728147
29	Basal transcription factors_Homo sapiens_hsa03022	1.24329691
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.24105271
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.20160948
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.18711556
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18652366
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.15535780
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.13402139
36	RNA degradation_Homo sapiens_hsa03018	1.13314042
37	Morphine addiction_Homo sapiens_hsa05032	1.13304502
38	Sulfur metabolism_Homo sapiens_hsa00920	1.12626011
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08896185
40	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.07489024
41	Peroxisome_Homo sapiens_hsa04146	1.05920235
42	One carbon pool by folate_Homo sapiens_hsa00670	1.05007570
43	Selenocompound metabolism_Homo sapiens_hsa00450	1.03342954
44	GABAergic synapse_Homo sapiens_hsa04727	1.03235373
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02899773
46	Fatty acid elongation_Homo sapiens_hsa00062	1.02547583
47	Non-homologous end-joining_Homo sapiens_hsa03450	1.01318532
48	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.99496039
49	Insulin secretion_Homo sapiens_hsa04911	0.97552134
50	Fatty acid degradation_Homo sapiens_hsa00071	0.97488845
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.97137785
52	Circadian entrainment_Homo sapiens_hsa04713	0.95101100
53	Olfactory transduction_Homo sapiens_hsa04740	0.94702594
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94046233
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.92993944
56	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.91011953
57	Circadian rhythm_Homo sapiens_hsa04710	0.90083392
58	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.83755425
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83623156
60	Regulation of autophagy_Homo sapiens_hsa04140	0.80928480
61	Retinol metabolism_Homo sapiens_hsa00830	0.80726563
62	Proteasome_Homo sapiens_hsa03050	0.80454499
63	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80299165
64	Caffeine metabolism_Homo sapiens_hsa00232	0.79544351
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.79435396
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.73990392
67	Fatty acid metabolism_Homo sapiens_hsa01212	0.73890537
68	Glutamatergic synapse_Homo sapiens_hsa04724	0.73686730
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73466118
70	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73298134
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73091974
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71769809
73	Purine metabolism_Homo sapiens_hsa00230	0.71029106
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67751756
75	Mismatch repair_Homo sapiens_hsa03430	0.67648947
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67540490
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66273306
78	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.66054773
79	RNA transport_Homo sapiens_hsa03013	0.64959136
80	Serotonergic synapse_Homo sapiens_hsa04726	0.63727119
81	Metabolic pathways_Homo sapiens_hsa01100	0.63718906
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60799629
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.58956236
84	Sulfur relay system_Homo sapiens_hsa04122	0.57362826
85	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56100488
86	Nucleotide excision repair_Homo sapiens_hsa03420	0.55314070
87	Oocyte meiosis_Homo sapiens_hsa04114	0.53900346
88	Dopaminergic synapse_Homo sapiens_hsa04728	0.53647705
89	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53516386
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.53350939
91	Renin secretion_Homo sapiens_hsa04924	0.48264573
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47484857
93	Cocaine addiction_Homo sapiens_hsa05030	0.45343457
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44183697
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43105229
96	Ribosome_Homo sapiens_hsa03010	0.42681274
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42503219
98	ABC transporters_Homo sapiens_hsa02010	0.42414802
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.42394917
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.41613417

C15ORF41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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