C15ORF52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)6.42554668
2actin-myosin filament sliding (GO:0033275)5.19580480
3muscle filament sliding (GO:0030049)5.19580480
4cell-substrate junction assembly (GO:0007044)4.66326269
5actin-mediated cell contraction (GO:0070252)4.65716819
6cell adhesion mediated by integrin (GO:0033627)4.65052403
7desmosome organization (GO:0002934)4.63025677
8plasma membrane repair (GO:0001778)4.50737160
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.37725005
10negative regulation of protein localization to cell surface (GO:2000009)4.35305364
11sarcomere organization (GO:0045214)4.31230710
12regulation of skeletal muscle contraction (GO:0014819)4.30582706
13endodermal cell differentiation (GO:0035987)3.93093953
14regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.73268267
15skin morphogenesis (GO:0043589)3.72326686
16actin filament-based movement (GO:0030048)3.69959879
17regulation of the force of heart contraction (GO:0002026)3.57857024
18mesodermal cell differentiation (GO:0048333)3.46667502
19bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37601011
20regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.37246606
21actomyosin structure organization (GO:0031032)3.36956177
22response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.35487912
23focal adhesion assembly (GO:0048041)3.35399218
24cell-substrate adherens junction assembly (GO:0007045)3.35399218
25myofibril assembly (GO:0030239)3.35225842
26response to muscle activity (GO:0014850)3.30275691
27cardiac myofibril assembly (GO:0055003)3.29925765
28hypotonic response (GO:0006971)3.28033069
29substrate-dependent cell migration (GO:0006929)3.26774264
30actin filament depolymerization (GO:0030042)3.26319443
31sarcoplasmic reticulum calcium ion transport (GO:0070296)3.21421935
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.15309614
33epithelial cell-cell adhesion (GO:0090136)3.14718221
34adherens junction assembly (GO:0034333)3.07344769
35cellular response to vitamin (GO:0071295)3.06515502
36regulation of integrin-mediated signaling pathway (GO:2001044)3.06484279
37membrane raft organization (GO:0031579)3.01010115
38regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.00158104
39skeletal muscle contraction (GO:0003009)2.99358679
40regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.97189586
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.96871501
42positive regulation of blood vessel endothelial cell migration (GO:0043536)2.96091045
43positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.95519838
44negative regulation of chondrocyte differentiation (GO:0032331)2.94830072
45myoblast fusion (GO:0007520)2.89055042
46muscle contraction (GO:0006936)2.88585236
47protein localization to endosome (GO:0036010)2.87348126
48regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.86854456
49pericardium development (GO:0060039)2.86247394
50striated muscle contraction (GO:0006941)2.84148755
51endothelial cell morphogenesis (GO:0001886)2.83520984
52atrioventricular valve morphogenesis (GO:0003181)2.81121136
53cardiac muscle contraction (GO:0060048)2.78722456
54muscle cell migration (GO:0014812)2.77824105
55response to gravity (GO:0009629)2.76536744
56regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.75738817
57cellular response to vitamin D (GO:0071305)2.74753217
58response to inactivity (GO:0014854)2.74008819
59regulation of relaxation of muscle (GO:1901077)2.72949665
60barbed-end actin filament capping (GO:0051016)2.72684401
61regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.71060861
62positive regulation of receptor recycling (GO:0001921)2.70994156
63regulation of protein localization to cell surface (GO:2000008)2.68591865
64syncytium formation by plasma membrane fusion (GO:0000768)2.68272559
65basement membrane organization (GO:0071711)2.68019772
66kidney mesenchyme development (GO:0072074)2.67174454
67vascular endothelial growth factor signaling pathway (GO:0038084)2.66754001
68endocardial cushion development (GO:0003197)2.65395871
69cardiac muscle cell development (GO:0055013)2.64266769
70endothelial cell chemotaxis (GO:0035767)2.64036388
71renal filtration (GO:0097205)2.63848872
72positive regulation of osteoblast proliferation (GO:0033690)2.63818982
73regulation of actin filament-based movement (GO:1903115)2.63083062
74type B pancreatic cell proliferation (GO:0044342)2.62517254
75stress fiber assembly (GO:0043149)2.60997994
76extracellular fibril organization (GO:0043206)2.60760375
77positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.59325576
78muscle system process (GO:0003012)2.59119445
79regulation of hippo signaling (GO:0035330)2.56781939
80skeletal muscle fiber development (GO:0048741)2.56594615
81chondrocyte proliferation (GO:0035988)2.55566848
82gap junction assembly (GO:0016264)2.53382857
83muscle tissue morphogenesis (GO:0060415)2.53292379
84cardiac cell development (GO:0055006)2.53047123
85negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.52124818
86regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.51216632
87cell junction assembly (GO:0034329)2.51173479
88regulation of striated muscle contraction (GO:0006942)2.49203529
89protein hydroxylation (GO:0018126)2.48870929
90wound healing, spreading of epidermal cells (GO:0035313)2.47953301
91protein heterotrimerization (GO:0070208)2.46696063
92negative regulation of cell size (GO:0045792)2.46369274
93cardiac muscle tissue morphogenesis (GO:0055008)2.44624721
94regulation of transforming growth factor beta2 production (GO:0032909)2.44358330
95COPI coating of Golgi vesicle (GO:0048205)2.42787818
96Golgi transport vesicle coating (GO:0048200)2.42787818
97SMAD protein complex assembly (GO:0007183)2.41972816
98extracellular matrix assembly (GO:0085029)2.41907365
99regulation of apoptotic process involved in morphogenesis (GO:1902337)2.40926542
100negative regulation of nitric-oxide synthase activity (GO:0051001)2.38148890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.00737888
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.55675040
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.36341766
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.35390300
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.69034247
6* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.58063356
7RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.48068609
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.47991190
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.47691860
10SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.44572689
11SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.44572689
12* GATA2_21666600_ChIP-Seq_HMVEC_Human2.28609573
13CJUN_26792858_Chip-Seq_BT549_Human2.28423329
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.18839352
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.18475219
16ESR1_21235772_ChIP-Seq_MCF-7_Human2.12011129
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.05545872
18PPAR_26484153_Chip-Seq_NCI-H1993_Human2.03721523
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.01082650
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99662405
21JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97815753
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.97385104
23* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.96283332
24JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.93956736
25SOX9_24532713_ChIP-Seq_HFSC_Mouse1.91948849
26TBX20_22080862_ChIP-Seq_HEART_Mouse1.91190514
27TBX20_22328084_ChIP-Seq_HEART_Mouse1.91190514
28BRD4_25478319_ChIP-Seq_HGPS_Human1.90395096
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89521332
30CLOCK_20551151_ChIP-Seq_293T_Human1.84795546
31P63_26484246_Chip-Seq_KERATINOCYTES_Human1.83122318
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82383638
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81560402
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78593522
35ZNF263_19887448_ChIP-Seq_K562_Human1.77748532
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74914782
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.67139573
38* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.66163186
39* RACK7_27058665_Chip-Seq_MCF-7_Human1.64707704
40* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61601137
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61456128
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60825029
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59121859
44TP53_22127205_ChIP-Seq_IMR90_Human1.58915210
45* ATF3_27146783_Chip-Seq_COLON_Human1.57263470
46MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.57147776
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54488928
48* UBF1/2_26484160_Chip-Seq_HMECs_Human1.54481186
49ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52747104
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50395011
51TP53_23651856_ChIP-Seq_MEFs_Mouse1.48765471
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48631164
53* LXR_22292898_ChIP-Seq_THP-1_Human1.35637246
54TP53_16413492_ChIP-PET_HCT116_Human1.35636150
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34991732
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.34500182
57SOX2_20726797_ChIP-Seq_SW620_Human1.33097716
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31902462
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30305318
60NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29685776
61SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24750965
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24397667
63SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23459149
64* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.18820483
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17526169
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16312418
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16312418
68CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14081998
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.12793049
70* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12605627
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11071752
72TP53_18474530_ChIP-ChIP_U2OS_Human1.10108027
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.07333103
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06360424
75* TP63_22573176_ChIP-Seq_HFKS_Human1.05221501
76FOXO3_23340844_ChIP-Seq_DLD1_Human1.04429507
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02232488
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01715634
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99053295
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97906220
81SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95489469
82GATA4_21415370_ChIP-Seq_HL-1_Mouse0.95318649
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94651345
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94089961
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93435474
86* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92254828
87* TP63_23658742_ChIP-Seq_EP156T_Human0.91371093
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89412531
89LXR_22158963_ChIP-Seq_LIVER_Mouse0.88648569
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87190592
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87162640
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86553333
93AHR_22903824_ChIP-Seq_MCF-7_Human0.84696803
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82543511
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82042158
96CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81426380
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81142619
98CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80522537
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.80478977
100WT1_19549856_ChIP-ChIP_CCG9911_Human0.79427369

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.47557425
2MP0008438_abnormal_cutaneous_collagen3.64175347
3MP0000749_muscle_degeneration3.59163517
4MP0003950_abnormal_plasma_membrane3.45905284
5MP0004084_abnormal_cardiac_muscle3.32114645
6MP0003705_abnormal_hypodermis_morpholog3.23182157
7MP0003566_abnormal_cell_adhesion3.05529170
8MP0004272_abnormal_basement_membrane3.02103482
9MP0004036_abnormal_muscle_relaxation2.88962618
10MP0010368_abnormal_lymphatic_system2.42221308
11MP0001958_emphysema2.32648232
12MP0005330_cardiomyopathy2.28477882
13MP0000013_abnormal_adipose_tissue2.15118918
14MP0004087_abnormal_muscle_fiber2.14258323
15MP0005257_abnormal_intraocular_pressure2.12812551
16MP0003279_aneurysm2.09586697
17MP0005275_abnormal_skin_tensile2.07218359
18MP0000759_abnormal_skeletal_muscle2.00978054
19MP0000750_abnormal_muscle_regeneration1.99298271
20MP0009780_abnormal_chondrocyte_physiolo1.99248782
21MP0005023_abnormal_wound_healing1.98959083
22MP0005451_abnormal_body_composition1.96630314
23MP0005620_abnormal_muscle_contractility1.87687516
24MP0003646_muscle_fatigue1.86570832
25MP0004145_abnormal_muscle_electrophysio1.81191935
26MP0006138_congestive_heart_failure1.80565787
27MP0002877_abnormal_melanocyte_morpholog1.78931671
28MP0002972_abnormal_cardiac_muscle1.77925923
29MP0002269_muscular_atrophy1.76310954
30MP0000733_abnormal_muscle_development1.75485824
31MP0000747_muscle_weakness1.75453827
32MP0003091_abnormal_cell_migration1.72473413
33MP0002332_abnormal_exercise_endurance1.70934782
34MP0002106_abnormal_muscle_physiology1.69733059
35MP0005623_abnormal_meninges_morphology1.66151705
36MP0004233_abnormal_muscle_weight1.64788199
37MP0008775_abnormal_heart_ventricle1.64533811
38MP0000579_abnormal_nail_morphology1.64205508
39MP0002060_abnormal_skin_morphology1.62605935
40MP0000003_abnormal_adipose_tissue1.55898776
41MP0001849_ear_inflammation1.54930661
42MP0000762_abnormal_tongue_morphology1.53361014
43MP0009840_abnormal_foam_cell1.50065814
44MP0005369_muscle_phenotype1.46922194
45MP0004510_myositis1.45114524
46MP0000467_abnormal_esophagus_morphology1.39998607
47MP0004215_abnormal_myocardial_fiber1.39737537
48MP0001348_abnormal_lacrimal_gland1.35959529
49MP0003191_abnormal_cellular_cholesterol1.32914409
50MP0005670_abnormal_white_adipose1.32464849
51MP0000767_abnormal_smooth_muscle1.32115256
52MP0009384_cardiac_valve_regurgitation1.31998895
53MP0004858_abnormal_nervous_system1.31455969
54MP0002896_abnormal_bone_mineralization1.29897857
55MP0002837_dystrophic_cardiac_calcinosis1.22080668
56MP0005165_increased_susceptibility_to1.21933094
57MP0003828_pulmonary_edema1.21538944
58MP0004130_abnormal_muscle_cell1.19613819
59MP0010630_abnormal_cardiac_muscle1.19099473
60MP0002108_abnormal_muscle_morphology1.15035447
61MP0005409_darkened_coat_color1.15028661
62MP0003045_fibrosis1.14105019
63MP0009053_abnormal_anal_canal1.13741569
64MP0001661_extended_life_span1.13253060
65MP0005171_absent_coat_pigmentation1.11943847
66MP0004484_altered_response_of1.11133203
67MP0010030_abnormal_orbit_morphology1.11038106
68MP0001544_abnormal_cardiovascular_syste1.10422081
69MP0005385_cardiovascular_system_phenoty1.10422081
70MP0005595_abnormal_vascular_smooth1.09568106
71MP0001542_abnormal_bone_strength1.07584039
72MP0005503_abnormal_tendon_morphology1.07309893
73MP0000534_abnormal_ureter_morphology1.06998198
74MP0003453_abnormal_keratinocyte_physiol0.99267004
75MP0001299_abnormal_eye_distance/0.97083776
76MP0001879_abnormal_lymphatic_vessel0.96828042
77MP0003941_abnormal_skin_development0.93829783
78MP0005375_adipose_tissue_phenotype0.92658766
79MP0010352_gastrointestinal_tract_polyps0.85969619
80MP0005164_abnormal_response_to0.82405693
81MP0002128_abnormal_blood_circulation0.82363764
82MP0005508_abnormal_skeleton_morphology0.80753458
83MP0005197_abnormal_uvea_morphology0.77074617
84MP0010234_abnormal_vibrissa_follicle0.74993107
85MP0003137_abnormal_impulse_conducting0.74596868
86MP0001243_abnormal_dermal_layer0.73465024
87MP0010386_abnormal_urinary_bladder0.72100399
88MP0004085_abnormal_heartbeat0.71978704
89MP0004185_abnormal_adipocyte_glucose0.71669194
90MP0005501_abnormal_skin_physiology0.71303661
91MP0001216_abnormal_epidermal_layer0.70442346
92MP0002295_abnormal_pulmonary_circulatio0.69862710
93MP0005058_abnormal_lysosome_morphology0.69208172
94MP0000266_abnormal_heart_morphology0.68385572
95MP0010771_integument_phenotype0.67884840
96MP0000249_abnormal_blood_vessel0.67663949
97MP0005360_urolithiasis0.66749887
98MP0000230_abnormal_systemic_arterial0.66364250
99MP0001614_abnormal_blood_vessel0.66311048
100MP0002168_other_aberrant_phenotype0.65468218

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)5.49735299
2Nemaline bodies (HP:0003798)5.21611670
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.14352569
4Muscle fiber inclusion bodies (HP:0100299)5.13314418
5Protrusio acetabuli (HP:0003179)4.43368683
6Exercise-induced myalgia (HP:0003738)4.40391594
7Distal lower limb muscle weakness (HP:0009053)4.36284133
8Premature rupture of membranes (HP:0001788)4.28423791
9Increased connective tissue (HP:0009025)4.13048506
10Hyporeflexia of lower limbs (HP:0002600)3.91279757
11Atrophic scars (HP:0001075)3.70318459
12Distal lower limb amyotrophy (HP:0008944)3.68475972
13Round ear (HP:0100830)3.54673794
14Aortic aneurysm (HP:0004942)3.47463373
15Muscle fiber splitting (HP:0003555)3.46510379
16Spinal rigidity (HP:0003306)3.45145967
17Mildly elevated creatine phosphokinase (HP:0008180)3.33774543
18Abnormality of the calf musculature (HP:0001430)3.31433072
19Abnormality of skeletal muscle fiber size (HP:0012084)3.26301991
20Asymmetric septal hypertrophy (HP:0001670)3.23032141
21Aortic dissection (HP:0002647)3.20692711
22Increased variability in muscle fiber diameter (HP:0003557)3.20624776
23Arterial tortuosity (HP:0005116)3.20218734
24Exercise-induced muscle cramps (HP:0003710)3.17089099
25EMG: myopathic abnormalities (HP:0003458)3.10526565
26Difficulty climbing stairs (HP:0003551)3.08799522
27Vascular tortuosity (HP:0004948)3.08476769
28Bundle branch block (HP:0011710)3.05665251
29Fragile skin (HP:0001030)3.03644389
30Neck muscle weakness (HP:0000467)3.03584348
31Ulnar deviation of the wrist (HP:0003049)2.99899814
32Sudden death (HP:0001699)2.99037355
33Muscle hypertrophy of the lower extremities (HP:0008968)2.97479361
34Ventricular tachycardia (HP:0004756)2.94082744
35Right ventricular cardiomyopathy (HP:0011663)2.88836313
36Calf muscle hypertrophy (HP:0008981)2.81652745
37Lipoatrophy (HP:0100578)2.71510945
38Cervical subluxation (HP:0003308)2.65686836
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.65302901
40Distal arthrogryposis (HP:0005684)2.63822634
41Ankle contracture (HP:0006466)2.60213030
42Lower limb amyotrophy (HP:0007210)2.59246263
43Vertebral compression fractures (HP:0002953)2.55499199
44Milia (HP:0001056)2.50274541
45Myopathic facies (HP:0002058)2.48440770
46Scapular winging (HP:0003691)2.39375137
47Subaortic stenosis (HP:0001682)2.39143219
48Abnormality of the left ventricular outflow tract (HP:0011103)2.39143219
49Myoglobinuria (HP:0002913)2.36651523
50Limb-girdle muscle atrophy (HP:0003797)2.36536798
51Reduced subcutaneous adipose tissue (HP:0003758)2.33734836
52Spondylolisthesis (HP:0003302)2.32463674
53Broad face (HP:0000283)2.28076206
54Follicular hyperkeratosis (HP:0007502)2.25090892
55Achilles tendon contracture (HP:0001771)2.24579431
56Abnormal atrioventricular conduction (HP:0005150)2.24539005
57Slender build (HP:0001533)2.23833453
58Cardiovascular calcification (HP:0011915)2.22857216
59Wormian bones (HP:0002645)2.21471519
60Distal upper limb amyotrophy (HP:0007149)2.17571385
61Upper limb amyotrophy (HP:0009129)2.17571385
62Osteolytic defects of the hand bones (HP:0009699)2.17096791
63Osteolytic defects of the phalanges of the hand (HP:0009771)2.17096791
64Short nail (HP:0001799)2.16790861
65Atrial fibrillation (HP:0005110)2.14244277
66Generalized amyotrophy (HP:0003700)2.13522537
67Natal tooth (HP:0000695)2.13230274
68Shallow orbits (HP:0000586)2.13201522
69Gowers sign (HP:0003391)2.12491023
70Dilated cardiomyopathy (HP:0001644)2.09621284
71Abnormality of the Achilles tendon (HP:0005109)2.09258596
72Popliteal pterygium (HP:0009756)2.07695788
73Mitral stenosis (HP:0001718)2.07532393
74Muscle stiffness (HP:0003552)2.05281894
75Elbow flexion contracture (HP:0002987)2.04017050
76Hip contracture (HP:0003273)2.02593385
77Fatigable weakness (HP:0003473)2.01339114
78Abnormality of the neuromuscular junction (HP:0003398)2.01339114
79Cerebral aneurysm (HP:0004944)2.01188806
80Rhabdomyolysis (HP:0003201)1.99180200
81Muscular dystrophy (HP:0003560)1.94945556
82Onycholysis (HP:0001806)1.94022775
83Bradycardia (HP:0001662)1.93255845
84Pterygium (HP:0001059)1.91796531
85Ulnar bowing (HP:0003031)1.90062686
86Myotonia (HP:0002486)1.89996928
87Vascular calcification (HP:0004934)1.89704594
88Difficulty running (HP:0009046)1.87370008
89Aortic regurgitation (HP:0001659)1.87105139
90Ventricular arrhythmia (HP:0004308)1.85938248
91Primary atrial arrhythmia (HP:0001692)1.85170224
92Aneurysm (HP:0002617)1.82748645
93Heart block (HP:0012722)1.82650125
94Fragile nails (HP:0001808)1.82028330
95Supraventricular tachycardia (HP:0004755)1.81243529
96Bladder diverticulum (HP:0000015)1.80493241
97Supraventricular arrhythmia (HP:0005115)1.79708516
98Increased mean platelet volume (HP:0011877)1.79589950
99EMG: neuropathic changes (HP:0003445)1.79202770
100Limb-girdle muscle weakness (HP:0003325)1.77213851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.25420246
2EPHA24.06987751
3MST1R3.78675833
4MYLK3.65759971
5OBSCN3.02975867
6LMTK22.84110997
7MET2.81489031
8PHKG22.66290816
9PHKG12.66290816
10PTK22.39831074
11LIMK12.18944381
12IRAK32.15329995
13SIK11.97226507
14TRPM71.89362761
15PDGFRA1.88684264
16MAPKAPK31.79313599
17TRIB31.71844020
18EPHB11.68618696
19PIK3CG1.65401740
20NEK91.65051134
21PAK41.61608211
22NTRK11.60332486
23EPHB21.57293071
24ERN11.55148146
25TESK11.53820921
26RIPK11.48576985
27MUSK1.45996818
28MAP3K31.41528427
29PTK2B1.39586831
30PRKD21.37379144
31TGFBR21.36591940
32MOS1.35635648
33STK381.29352528
34PAK21.26230279
35FLT31.22622730
36ERBB41.21703879
37MAP3K71.20635268
38DMPK1.16590809
39MAP2K31.11891623
40LATS21.09012174
41ICK1.08242647
42LATS11.07148681
43DDR21.06635670
44CDC42BPA1.03960693
45ROCK10.99960253
46CDK80.88636415
47MAP3K60.88332608
48BMX0.86869800
49PIM20.85396696
50CAMK2G0.84644134
51MAP2K10.79696246
52CAMK2D0.77863171
53ARAF0.77856294
54PRKG20.76632382
55MTOR0.73981407
56STK38L0.73722626
57ABL20.71681181
58ROCK20.71619393
59ILK0.71288716
60RPS6KA20.71037463
61AKT30.70221440
62PDGFRB0.64193478
63ADRBK10.60762976
64MAPK70.60546132
65DAPK30.60388402
66MAPK120.59375191
67PTK60.59330865
68PRKD10.59053364
69NME20.56297448
70GSK3A0.49385831
71FER0.49342481
72ZAP700.47532741
73PAK60.43744113
74CAMK2B0.43325198
75MAPK110.43322084
76PKN20.41734377
77MELK0.41257197
78DAPK20.37943788
79MAPKAPK20.35882426
80PDPK10.35457764
81MAP3K130.33595845
82PRKAA20.32612759
83RPS6KL10.31768425
84RPS6KC10.31768425
85PRKD30.31713054
86PRKCI0.31554295
87STK30.30848544
88SMG10.30547226
89AKT20.30046873
90PAK10.29096225
91TAOK20.28786772
92PRKAA10.27820908
93RPS6KA60.27155713
94PINK10.26870385
95TGFBR10.25667000
96HIPK20.25443710
97PRKCE0.24762904
98CAMK2A0.23004652
99TIE10.22150109
100MARK20.22122663

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.08271518
2Dilated cardiomyopathy_Homo sapiens_hsa054143.87301198
3ECM-receptor interaction_Homo sapiens_hsa045123.74665769
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.68397751
5Focal adhesion_Homo sapiens_hsa045102.92527042
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.18288532
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.75478286
8Bladder cancer_Homo sapiens_hsa052191.69874319
9Regulation of actin cytoskeleton_Homo sapiens_hsa048101.66460732
10Small cell lung cancer_Homo sapiens_hsa052221.64719928
11Proteoglycans in cancer_Homo sapiens_hsa052051.62752805
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.61561668
13Amoebiasis_Homo sapiens_hsa051461.53997575
14Adherens junction_Homo sapiens_hsa045201.51212090
15Other glycan degradation_Homo sapiens_hsa005111.50137573
16Circadian rhythm_Homo sapiens_hsa047101.46066444
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45723759
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36722644
19Vascular smooth muscle contraction_Homo sapiens_hsa042701.28620912
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27451932
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19222229
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18907236
23Fructose and mannose metabolism_Homo sapiens_hsa000511.14647654
24Galactose metabolism_Homo sapiens_hsa000521.12945556
25Pentose phosphate pathway_Homo sapiens_hsa000301.12686649
26Tight junction_Homo sapiens_hsa045301.11396048
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09623216
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08174461
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08041945
30Glucagon signaling pathway_Homo sapiens_hsa049221.06821963
31Insulin resistance_Homo sapiens_hsa049311.06351519
32Cardiac muscle contraction_Homo sapiens_hsa042601.03660674
33Platelet activation_Homo sapiens_hsa046111.03431452
34Insulin signaling pathway_Homo sapiens_hsa049101.01332148
35PI3K-Akt signaling pathway_Homo sapiens_hsa041510.95018306
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94057650
37Protein digestion and absorption_Homo sapiens_hsa049740.92466806
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.91227729
39Arginine and proline metabolism_Homo sapiens_hsa003300.90744916
40Hippo signaling pathway_Homo sapiens_hsa043900.88764631
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87881593
42Calcium signaling pathway_Homo sapiens_hsa040200.85966503
43Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85911837
44Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79283347
45Oxytocin signaling pathway_Homo sapiens_hsa049210.79272938
46Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78856265
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.78574908
48Chronic myeloid leukemia_Homo sapiens_hsa052200.78300947
49AMPK signaling pathway_Homo sapiens_hsa041520.76678551
50Melanoma_Homo sapiens_hsa052180.76650130
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76278972
52GnRH signaling pathway_Homo sapiens_hsa049120.76132747
53Pancreatic cancer_Homo sapiens_hsa052120.75628442
54Endocytosis_Homo sapiens_hsa041440.75220310
55Pathways in cancer_Homo sapiens_hsa052000.71462316
56Sulfur metabolism_Homo sapiens_hsa009200.71334367
57Renin secretion_Homo sapiens_hsa049240.70980256
58Lysosome_Homo sapiens_hsa041420.69758007
59Salivary secretion_Homo sapiens_hsa049700.69275568
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.68549766
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68326118
62Gastric acid secretion_Homo sapiens_hsa049710.67042926
63Glioma_Homo sapiens_hsa052140.66942819
64VEGF signaling pathway_Homo sapiens_hsa043700.65071731
65Gap junction_Homo sapiens_hsa045400.63867156
66Starch and sucrose metabolism_Homo sapiens_hsa005000.62768551
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62569887
68Bile secretion_Homo sapiens_hsa049760.62329652
69Phenylalanine metabolism_Homo sapiens_hsa003600.58575582
70Carbon metabolism_Homo sapiens_hsa012000.57994341
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57946045
72Axon guidance_Homo sapiens_hsa043600.57149196
73Sulfur relay system_Homo sapiens_hsa041220.56000261
74Notch signaling pathway_Homo sapiens_hsa043300.55167024
75Lysine degradation_Homo sapiens_hsa003100.54844265
76Renal cell carcinoma_Homo sapiens_hsa052110.54632495
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.53735519
78PPAR signaling pathway_Homo sapiens_hsa033200.53679572
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51994761
80MicroRNAs in cancer_Homo sapiens_hsa052060.50806162
81Melanogenesis_Homo sapiens_hsa049160.48875422
82Prion diseases_Homo sapiens_hsa050200.48754885
83Complement and coagulation cascades_Homo sapiens_hsa046100.48645817
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46035637
85Sphingolipid metabolism_Homo sapiens_hsa006000.45656466
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44716077
87Biosynthesis of amino acids_Homo sapiens_hsa012300.44045416
88Thyroid hormone synthesis_Homo sapiens_hsa049180.43178150
89Pancreatic secretion_Homo sapiens_hsa049720.43132552
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42385793
91Thyroid cancer_Homo sapiens_hsa052160.42303846
92mTOR signaling pathway_Homo sapiens_hsa041500.41226117
93TGF-beta signaling pathway_Homo sapiens_hsa043500.39854457
94Histidine metabolism_Homo sapiens_hsa003400.39848300
95Shigellosis_Homo sapiens_hsa051310.39282533
96Insulin secretion_Homo sapiens_hsa049110.38732269
97Tyrosine metabolism_Homo sapiens_hsa003500.38579304
98beta-Alanine metabolism_Homo sapiens_hsa004100.37717600
99ABC transporters_Homo sapiens_hsa020100.37390594
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37145616

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