C15ORF53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.66582539
2DNA deamination (GO:0045006)8.64365197
3regulation of regulatory T cell differentiation (GO:0045589)6.91396538
4cellular response to interleukin-15 (GO:0071350)5.71318148
5response to interleukin-15 (GO:0070672)5.67164042
6positive regulation of interleukin-8 secretion (GO:2000484)5.60853921
7positive T cell selection (GO:0043368)5.42133536
8pyrimidine nucleoside catabolic process (GO:0046135)5.25517671
9negative T cell selection (GO:0043383)5.14895469
10negative regulation of T cell apoptotic process (GO:0070233)5.12474056
11negative regulation of viral genome replication (GO:0045071)5.09477029
12regulation of B cell receptor signaling pathway (GO:0050855)4.95986482
13eosinophil chemotaxis (GO:0048245)4.94465566
14T cell migration (GO:0072678)4.80710796
15positive regulation of gamma-delta T cell activation (GO:0046645)4.70738301
16regulation of activation of Janus kinase activity (GO:0010533)4.63119290
17dendritic cell chemotaxis (GO:0002407)4.59124710
18regulation of chronic inflammatory response (GO:0002676)4.57477863
19negative regulation by host of viral transcription (GO:0043922)4.54479298
20eosinophil migration (GO:0072677)4.44574946
21positive regulation of alpha-beta T cell proliferation (GO:0046641)4.40116547
22positive regulation of T cell chemotaxis (GO:0010820)4.37782610
23regulation of T cell chemotaxis (GO:0010819)4.37782610
24positive thymic T cell selection (GO:0045059)4.36686180
25lymphocyte chemotaxis (GO:0048247)4.32087677
26positive regulation of monocyte chemotaxis (GO:0090026)4.30239392
27chemokine-mediated signaling pathway (GO:0070098)4.28669169
28regulation of lymphocyte chemotaxis (GO:1901623)4.24861908
29T cell costimulation (GO:0031295)4.13890211
30negative regulation of B cell proliferation (GO:0030889)4.13728583
31negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.12713775
32lymphocyte costimulation (GO:0031294)4.08555229
33regulation of interleukin-2 biosynthetic process (GO:0045076)4.05241131
34regulation of viral genome replication (GO:0045069)4.01328622
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.99885149
36macrophage chemotaxis (GO:0048246)3.97337795
37T cell receptor signaling pathway (GO:0050852)3.97315379
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.96838904
39thymic T cell selection (GO:0045061)3.93076259
40positive regulation of natural killer cell mediated immunity (GO:0002717)3.92954780
41T cell selection (GO:0045058)3.92651190
42regulation of interleukin-8 secretion (GO:2000482)3.89033448
43regulation of gamma-delta T cell differentiation (GO:0045586)3.85031777
44positive regulation of defense response to virus by host (GO:0002230)3.84168944
45positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.78851537
46regulation of alpha-beta T cell proliferation (GO:0046640)3.78561017
47negative thymic T cell selection (GO:0045060)3.77741617
48regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.73823548
49positive regulation of B cell differentiation (GO:0045579)3.73593529
50antigen receptor-mediated signaling pathway (GO:0050851)3.66577366
51dendritic cell migration (GO:0036336)3.62250978
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.60745688
53regulation of mononuclear cell migration (GO:0071675)3.59987760
54negative regulation of viral process (GO:0048525)3.58072795
55negative regulation of viral transcription (GO:0032897)3.57155873
56positive regulation of lymphocyte migration (GO:2000403)3.56747669
57cellular defense response (GO:0006968)3.56686546
58negative regulation of B cell activation (GO:0050869)3.54928778
59regulation of natural killer cell mediated immunity (GO:0002715)3.54557853
60regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.54557853
61regulation of T cell receptor signaling pathway (GO:0050856)3.53988227
62positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.52986811
63regulation of T cell tolerance induction (GO:0002664)3.49994381
64intestinal epithelial cell development (GO:0060576)3.40617007
65negative regulation of lymphocyte apoptotic process (GO:0070229)3.40212285
66negative regulation of T-helper cell differentiation (GO:0045623)3.38924379
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.38924379
68negative regulation of thymocyte apoptotic process (GO:0070244)3.37262483
69regulation of gamma-delta T cell activation (GO:0046643)3.32463484
70positive regulation of interleukin-4 production (GO:0032753)3.31180012
71regulation of B cell differentiation (GO:0045577)3.29718064
72negative regulation of T cell receptor signaling pathway (GO:0050860)3.28175018
73regulation of T-helper 1 cell differentiation (GO:0045625)3.27618906
74regulation of T cell apoptotic process (GO:0070232)3.24712296
75negative regulation of calcium ion transport into cytosol (GO:0010523)3.24297904
76regulation of interleukin-12 biosynthetic process (GO:0045075)3.23889943
77positive regulation of interleukin-1 beta secretion (GO:0050718)3.23340472
78regulation of leukocyte mediated cytotoxicity (GO:0001910)3.23165061
79positive regulation of calcium-mediated signaling (GO:0050850)3.21078884
80regulation of cell killing (GO:0031341)3.17227524
81positive regulation of macrophage differentiation (GO:0045651)3.16105562
82positive regulation of interleukin-2 production (GO:0032743)3.13172383
83positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13096510
84regulation of isotype switching to IgG isotypes (GO:0048302)3.11441875
85regulation of macrophage chemotaxis (GO:0010758)3.10046859
86negative regulation of bone resorption (GO:0045779)3.09187159
87regulation of lymphocyte apoptotic process (GO:0070228)3.08939981
88positive regulation of cell killing (GO:0031343)3.08041173
89granulocyte activation (GO:0036230)3.04747274
90positive regulation of interleukin-1 secretion (GO:0050716)3.03869282
91monocyte chemotaxis (GO:0002548)3.03627326
92positive regulation of T cell migration (GO:2000406)3.03228780
93cytolysis (GO:0019835)3.00159015
94DNA demethylation (GO:0080111)3.00123397
95positive regulation of tolerance induction (GO:0002645)2.97000381
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96191209
97cytidine metabolic process (GO:0046087)11.6227080
98cytidine catabolic process (GO:0006216)11.6227080
99cytidine deamination (GO:0009972)11.6227080
100pyrimidine ribonucleoside catabolic process (GO:0046133)10.6556147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.98996517
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.24839341
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.70145895
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.29922528
5IRF8_22096565_ChIP-ChIP_GC-B_Human5.20651582
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.42116706
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.38105984
8STAT4_19710469_ChIP-ChIP_TH1__Mouse3.14799860
9RUNX_20019798_ChIP-Seq_JUKART_Human3.14545463
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.91941194
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.84441069
12* MYB_26560356_Chip-Seq_TH2_Human2.79029449
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63420472
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.54521365
15* GATA3_27048872_Chip-Seq_THYMUS_Human2.42573374
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.33647059
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.30808061
18* MYB_26560356_Chip-Seq_TH1_Human2.22470238
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07810243
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.06746541
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04381230
22SCL_19346495_ChIP-Seq_HPC-7_Human2.04065993
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96720698
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92937689
25VDR_22108803_ChIP-Seq_LS180_Human1.91638172
26* GATA3_26560356_Chip-Seq_TH2_Human1.89833525
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.75338190
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75302384
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.73302080
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.72078583
31GATA1_22025678_ChIP-Seq_K562_Human1.71074864
32MAF_26560356_Chip-Seq_TH1_Human1.66072250
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60998536
34UTX_26944678_Chip-Seq_JUKART_Human1.57850525
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41738156
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39563270
37HTT_18923047_ChIP-ChIP_STHdh_Human1.38030697
38RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.36258189
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32344355
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31642249
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.28542835
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25977029
43MAF_26560356_Chip-Seq_TH2_Human1.25548408
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22813203
45TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20324184
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18990456
47PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17855453
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17404387
49GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16455833
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14891292
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.11120057
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.05592053
53FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04648587
54VDR_24787735_ChIP-Seq_THP-1_Human1.03649797
55SPI1_23547873_ChIP-Seq_NB4_Human1.00034589
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00007541
57GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99157908
58EGR1_19032775_ChIP-ChIP_M12_Human0.97343614
59NANOG_19829295_ChIP-Seq_ESCs_Human0.94730672
60SOX2_19829295_ChIP-Seq_ESCs_Human0.94730672
61* GATA3_26560356_Chip-Seq_TH1_Human0.93429225
62FOXP3_21729870_ChIP-Seq_TREG_Human0.93107802
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91890847
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91511820
65PRDM14_20953172_ChIP-Seq_ESCs_Human0.90327486
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85692787
67EGR1_23403033_ChIP-Seq_LIVER_Mouse0.84391546
68SMRT_27268052_Chip-Seq_Bcells_Human0.83623849
69CRX_20693478_ChIP-Seq_RETINA_Mouse0.83007554
70RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80819832
71* TAF2_19829295_ChIP-Seq_ESCs_Human0.79173419
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.78924804
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.78706079
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77750321
75HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77223655
76* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.77184293
77* FOXA1_25329375_ChIP-Seq_VCAP_Human0.77184293
78* CEBPB_22108803_ChIP-Seq_LS180_Human0.76844069
79PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75890543
80VDR_23849224_ChIP-Seq_CD4+_Human0.75061296
81BCAT_22108803_ChIP-Seq_LS180_Human0.74992155
82* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74923344
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.74670545
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.74240123
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74182716
86OCT4_18555785_Chip-Seq_ESCs_Mouse0.74119140
87SPI1_23127762_ChIP-Seq_K562_Human0.73722018
88RUNX1_27457419_Chip-Seq_LIVER_Mouse0.72787243
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.71944540
90RBPJ_21746931_ChIP-Seq_IB4_Human0.71415194
91OCT4_21477851_ChIP-Seq_ESCs_Mouse0.70541258
92GATA6_21074721_ChIP-Seq_CACO-2_Human0.70054333
93CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69858013
94SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.69712295
95TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.69274604
96SMAD1_18555785_Chip-Seq_ESCs_Mouse0.67492649
97POU3F2_20337985_ChIP-ChIP_501MEL_Human0.66914429
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66746875
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.66325078
100GATA2_19941826_ChIP-Seq_K562_Human0.65829854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to7.05806766
2MP0003763_abnormal_thymus_physiology3.97375850
3MP0009785_altered_susceptibility_to3.90783682
4MP0001835_abnormal_antigen_presentation3.59520147
5MP0002148_abnormal_hypersensitivity_rea3.52091472
6MP0005000_abnormal_immune_tolerance3.28857224
7MP0009333_abnormal_splenocyte_physiolog3.25888432
8MP0001800_abnormal_humoral_immune3.07672036
9MP0001873_stomach_inflammation3.05744906
10MP0003866_abnormal_defecation2.98648766
11MP0006082_CNS_inflammation2.83296330
12MP0002723_abnormal_immune_serum2.80790754
13MP0005025_abnormal_response_to2.73129610
14MP0010155_abnormal_intestine_physiology2.65932184
15MP0002420_abnormal_adaptive_immunity2.59292430
16MP0001819_abnormal_immune_cell2.54465377
17MP0005464_abnormal_platelet_physiology2.47901744
18MP0002398_abnormal_bone_marrow2.37330815
19MP0005387_immune_system_phenotype2.29656621
20MP0001790_abnormal_immune_system2.29656621
21MP0002452_abnormal_antigen_presenting2.23635922
22MP0005670_abnormal_white_adipose2.19090396
23MP0000716_abnormal_immune_system2.11917676
24MP0000703_abnormal_thymus_morphology2.11203523
25MP0003045_fibrosis2.06904102
26MP0000689_abnormal_spleen_morphology1.93880197
27MP0002405_respiratory_system_inflammati1.92554546
28MP0001845_abnormal_inflammatory_respons1.89780274
29MP0002722_abnormal_immune_system1.85741703
30MP0008877_abnormal_DNA_methylation1.80639234
31MP0001853_heart_inflammation1.71518613
32MP0002429_abnormal_blood_cell1.66239142
33MP0000685_abnormal_immune_system1.61852282
34MP0003436_decreased_susceptibility_to1.60606739
35MP0009764_decreased_sensitivity_to1.53236440
36MP0003448_altered_tumor_morphology1.52768325
37MP0004947_skin_inflammation1.52276396
38MP0005310_abnormal_salivary_gland1.49137112
39MP0002419_abnormal_innate_immunity1.45273349
40MP0002166_altered_tumor_susceptibility1.39033130
41MP0002877_abnormal_melanocyte_morpholog1.35314114
42MP0003786_premature_aging1.33144516
43MP0002933_joint_inflammation1.30330980
44MP0000343_altered_response_to1.28446830
45MP0003878_abnormal_ear_physiology1.24677787
46MP0005377_hearing/vestibular/ear_phenot1.24677787
47MP0009763_increased_sensitivity_to1.22364420
48MP0002163_abnormal_gland_morphology1.21889273
49MP0008469_abnormal_protein_level1.20655924
50MP0001919_abnormal_reproductive_system1.12122341
51MP0002693_abnormal_pancreas_physiology1.11442720
52MP0003183_abnormal_peptide_metabolism1.06767037
53MP0002277_abnormal_respiratory_mucosa1.00929420
54MP0002876_abnormal_thyroid_physiology1.00707736
55MP0003950_abnormal_plasma_membrane0.95038842
56MP0000465_gastrointestinal_hemorrhage0.94271739
57MP0004381_abnormal_hair_follicle0.89845593
58MP0005083_abnormal_biliary_tract0.89771620
59MP0002006_tumorigenesis0.89321823
60MP0009765_abnormal_xenobiotic_induced0.88807417
61MP0000372_irregular_coat_pigmentation0.88657507
62MP0006036_abnormal_mitochondrial_physio0.88408992
63MP0002998_abnormal_bone_remodeling0.88162792
64MP0001533_abnormal_skeleton_physiology0.84312356
65MP0005166_decreased_susceptibility_to0.80918555
66MP0002019_abnormal_tumor_incidence0.78841072
67MP0008007_abnormal_cellular_replicative0.78059590
68MP0002168_other_aberrant_phenotype0.77012729
69MP0003806_abnormal_nucleotide_metabolis0.76879703
70MP0002638_abnormal_pupillary_reflex0.75366938
71MP0002136_abnormal_kidney_physiology0.73236112
72MP0008057_abnormal_DNA_replication0.71558781
73MP0005075_abnormal_melanosome_morpholog0.70754853
74MP0006276_abnormal_autonomic_nervous0.70140115
75MP0006035_abnormal_mitochondrial_morpho0.69179064
76MP0008873_increased_physiological_sensi0.68379553
77MP0003787_abnormal_imprinting0.67030303
78MP0009643_abnormal_urine_homeostasis0.66173743
79MP0008872_abnormal_physiological_respon0.64704323
80MP0002909_abnormal_adrenal_gland0.63271367
81MP0001188_hyperpigmentation0.59965824
82MP0003724_increased_susceptibility_to0.58578396
83MP0002396_abnormal_hematopoietic_system0.56677278
84MP0000569_abnormal_digit_pigmentation0.56674342
85MP0001663_abnormal_digestive_system0.56614556
86MP0001666_abnormal_nutrient_absorption0.55214729
87MP0003075_altered_response_to0.54345200
88MP0001765_abnormal_ion_homeostasis0.54182119
89MP0005379_endocrine/exocrine_gland_phen0.52983437
90MP0010307_abnormal_tumor_latency0.52206237
91MP0003795_abnormal_bone_structure0.51511345
92MP0001968_abnormal_touch/_nociception0.50449350
93MP0001485_abnormal_pinna_reflex0.49873297
94MP0003137_abnormal_impulse_conducting0.49520631
95MP0005410_abnormal_fertilization0.48205982
96MP0002083_premature_death0.45870793
97MP0005167_abnormal_blood-brain_barrier0.45559402
98MP0001502_abnormal_circadian_rhythm0.44462249
99MP0000920_abnormal_myelination0.44065382
100MP0000858_altered_metastatic_potential0.43076255

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)8.20991273
2T lymphocytopenia (HP:0005403)7.13004293
3Abnormality of T cell number (HP:0011839)6.73588091
4Stomatitis (HP:0010280)6.41551044
5IgG deficiency (HP:0004315)5.64882449
6Abnormality of the prostate (HP:0008775)5.59024024
7Abnormality of T cells (HP:0002843)4.85766893
8Hypoproteinemia (HP:0003075)4.82270214
9Chronic diarrhea (HP:0002028)4.43971380
10Elevated erythrocyte sedimentation rate (HP:0003565)4.17461058
11Abnormal delayed hypersensitivity skin test (HP:0002963)4.03889215
12Ureteral stenosis (HP:0000071)4.03769318
13Pulmonary infiltrates (HP:0002113)3.76441686
14Aplastic anemia (HP:0001915)3.74394580
15Ureteral obstruction (HP:0006000)3.69273265
16Abnormality of male internal genitalia (HP:0000022)3.56521344
17Meningitis (HP:0001287)3.55558307
18Chronic obstructive pulmonary disease (HP:0006510)3.53917411
19Obstructive lung disease (HP:0006536)3.53917411
20Joint swelling (HP:0001386)3.53583255
21Hemoptysis (HP:0002105)3.51639820
22Severe combined immunodeficiency (HP:0004430)3.43917678
23IgA deficiency (HP:0002720)3.31451027
24Abnormality of eosinophils (HP:0001879)3.31190437
25Gangrene (HP:0100758)3.25216581
26Recurrent cutaneous fungal infections (HP:0011370)3.23144979
27Chronic mucocutaneous candidiasis (HP:0002728)3.23144979
28Chest pain (HP:0100749)3.23126333
29Increased IgM level (HP:0003496)3.21302202
30Cutaneous melanoma (HP:0012056)3.11860672
31Abnormality of macrophages (HP:0004311)3.04981583
32Thyroiditis (HP:0100646)3.03786378
33Abnormality of T cell physiology (HP:0011840)3.02471327
34Panhypogammaglobulinemia (HP:0003139)2.94512121
35Vasculitis (HP:0002633)2.92311775
36Eosinophilia (HP:0001880)2.91295564
37Pulmonary fibrosis (HP:0002206)2.90305936
38Gastrointestinal infarctions (HP:0005244)2.84437944
39Abnormality of the pleura (HP:0002103)2.81506653
40Recurrent viral infections (HP:0004429)2.78142571
41Follicular hyperkeratosis (HP:0007502)2.76902815
42Recurrent bronchitis (HP:0002837)2.71708160
43Petechiae (HP:0000967)2.70274710
44Pulmonary embolism (HP:0002204)2.68530656
45Autoimmune thrombocytopenia (HP:0001973)2.67810590
46Combined immunodeficiency (HP:0005387)2.67727290
47Recurrent fungal infections (HP:0002841)2.66092297
48Abnormal albumin level (HP:0012116)2.62281806
49Hypoalbuminemia (HP:0003073)2.62281806
50Lymphopenia (HP:0001888)2.54978725
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.47522195
52Neoplasm of the tracheobronchial system (HP:0100552)2.46820657
53Encephalitis (HP:0002383)2.45268387
54Epistaxis (HP:0000421)2.42796129
55Alopecia of scalp (HP:0002293)2.39470356
56Hypoplasia of the thymus (HP:0000778)2.36180009
57IgM deficiency (HP:0002850)2.34932723
58Polyneuropathy (HP:0001271)2.34367377
59Leukocytosis (HP:0001974)2.33601179
60Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30532568
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30532568
62Abnormality of the pericardium (HP:0001697)2.26173511
63Granulocytopenia (HP:0001913)2.23255697
64Retrobulbar optic neuritis (HP:0100654)2.23101049
65Optic neuritis (HP:0100653)2.23101049
66Papilledema (HP:0001085)2.22839884
67Lymphoma (HP:0002665)2.21673591
68Squamous cell carcinoma (HP:0002860)2.14814658
69Hemiplegia (HP:0002301)2.13031584
70Alveolar cell carcinoma (HP:0006519)2.12982188
71Renal cortical cysts (HP:0000803)2.09280142
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.09034741
73Arterial thrombosis (HP:0004420)2.07099969
74Zonular cataract (HP:0010920)2.05225697
75Abnormality of the fingertips (HP:0001211)2.05096171
76Mediastinal lymphadenopathy (HP:0100721)2.04124445
77Keratitis (HP:0000491)2.03697302
78Ectropion (HP:0000656)2.01952767
79Increased intramyocellular lipid droplets (HP:0012240)2.00266005
80Prolonged bleeding time (HP:0003010)1.99760467
81Abnormality of midbrain morphology (HP:0002418)1.96537034
82Molar tooth sign on MRI (HP:0002419)1.96537034
83Radial bowing (HP:0002986)1.95610249
84Hepatosplenomegaly (HP:0001433)1.95545566
85Pustule (HP:0200039)1.94979239
86Thrombophlebitis (HP:0004418)1.90854596
87Diplopia (HP:0000651)1.87372042
88Abnormality of binocular vision (HP:0011514)1.87372042
89Purpura (HP:0000979)1.87176138
90Poor speech (HP:0002465)1.86668071
91Agammaglobulinemia (HP:0004432)1.86065306
92Orchitis (HP:0100796)1.84319309
93Skin rash (HP:0000988)1.83785177
94Amaurosis fugax (HP:0100576)1.82819523
95Melanoma (HP:0002861)1.82320786
96Tetraplegia (HP:0002445)1.81683877
97Abnormality of the alveolar ridges (HP:0006477)1.79850176
98Dry hair (HP:0011359)1.79779290
993-Methylglutaconic aciduria (HP:0003535)1.78926228
100Recurrent otitis media (HP:0000403)1.76088377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK9.18894858
2MAP3K94.24691560
3MST43.83523583
4ITK3.64892172
5MAP4K12.94367172
6BUB12.55938794
7JAK32.54705293
8KDR2.25668769
9ADRBK22.23547318
10TEC2.16497334
11TRIM282.09184063
12EIF2AK12.05345025
13PIK3CG1.93519586
14GRK71.82461851
15ZAK1.80939287
16LCK1.64640197
17BTK1.60867180
18MAPKAPK31.47968988
19WNK41.34177603
20SYK1.31798278
21MAP2K61.31659426
22PIK3CA1.30467991
23CSK1.29264459
24FES1.26956593
25TAOK31.24109012
26EIF2AK31.24097699
27TYRO31.20601685
28CASK1.20380943
29MARK11.17876283
30GRK11.17367511
31TAF11.15845127
32FRK1.10756704
33PRKCQ1.04951169
34FYN0.99700059
35LYN0.94704776
36BCR0.93833223
37IKBKB0.89789274
38NUAK10.83083339
39MAP3K130.82890182
40CSF1R0.81127085
41IGF1R0.77410903
42IKBKE0.75238595
43RIPK40.73733397
44TESK20.72555321
45GRK60.72311757
46ZAP700.71223683
47JAK10.69784824
48STK390.68866172
49JAK20.68314703
50STK100.68218723
51MAPK110.64852241
52CDK80.59903517
53ACVR1B0.59381856
54IRAK40.58979022
55MYLK0.55255965
56HCK0.52257678
57PNCK0.51104723
58CAMKK20.50962231
59GRK50.49408699
60OXSR10.48347915
61BMPR20.47700710
62MAP3K120.46164549
63AKT30.45829648
64PAK10.44338108
65DAPK10.44161222
66BMPR1B0.42274291
67SIK30.41343425
68PDK10.40908998
69MAP3K140.39126898
70FGFR10.37819857
71DAPK20.35897700
72PIM10.35308391
73MELK0.34442478
74PRKCD0.32889250
75PRKCA0.32273671
76VRK20.30863263
77MAP3K110.29449881
78CHUK0.28996104
79CSNK1A10.28443545
80FGFR30.28049570
81MATK0.27822621
82PRKCB0.26796048
83MARK30.24449463
84TYK20.24379534
85KIT0.23948676
86NTRK20.23406093
87INSR0.23251040
88TIE10.22322086
89CAMK2A0.21804721
90PRKCH0.21764032
91BLK0.21601978
92EIF2AK20.20224336
93STK240.19721735
94BRSK20.19589973
95FGFR20.19559591
96CSNK1G30.18059567
97PRKCI0.15826583
98PRKACA0.15371957
99ROCK10.13923494
100ARAF0.13538791

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.37126037
2Graft-versus-host disease_Homo sapiens_hsa053324.36205528
3Autoimmune thyroid disease_Homo sapiens_hsa053204.34123787
4Allograft rejection_Homo sapiens_hsa053303.88071211
5T cell receptor signaling pathway_Homo sapiens_hsa046603.46952748
6Hematopoietic cell lineage_Homo sapiens_hsa046403.25442459
7Antigen processing and presentation_Homo sapiens_hsa046123.05531815
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.98455107
9Type I diabetes mellitus_Homo sapiens_hsa049402.86069658
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.80708231
11Rheumatoid arthritis_Homo sapiens_hsa053232.62317791
12Measles_Homo sapiens_hsa051622.61762637
13Proteasome_Homo sapiens_hsa030502.29854861
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.19935978
15Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.11380863
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.95726462
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.77874795
18Chemokine signaling pathway_Homo sapiens_hsa040621.73485556
19Viral myocarditis_Homo sapiens_hsa054161.57410680
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.56171424
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.53422197
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.51329290
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39693213
24Salmonella infection_Homo sapiens_hsa051321.23455552
25Asthma_Homo sapiens_hsa053101.20693641
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12125019
27Nitrogen metabolism_Homo sapiens_hsa009101.07331047
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.06571890
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04573400
30Linoleic acid metabolism_Homo sapiens_hsa005911.03099576
31RNA polymerase_Homo sapiens_hsa030200.95135496
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87449176
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86526454
34Herpes simplex infection_Homo sapiens_hsa051680.84920036
35Systemic lupus erythematosus_Homo sapiens_hsa053220.84373626
36Platelet activation_Homo sapiens_hsa046110.81778203
37Basal transcription factors_Homo sapiens_hsa030220.79121152
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77983182
39Osteoclast differentiation_Homo sapiens_hsa043800.77408661
40HTLV-I infection_Homo sapiens_hsa051660.75960348
41Staphylococcus aureus infection_Homo sapiens_hsa051500.74878100
42Shigellosis_Homo sapiens_hsa051310.74185410
43TNF signaling pathway_Homo sapiens_hsa046680.70345049
44Caffeine metabolism_Homo sapiens_hsa002320.66180833
45Apoptosis_Homo sapiens_hsa042100.65344057
46Influenza A_Homo sapiens_hsa051640.64711898
47Epstein-Barr virus infection_Homo sapiens_hsa051690.62045483
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60174932
49Oxidative phosphorylation_Homo sapiens_hsa001900.55702501
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54598150
51Leishmaniasis_Homo sapiens_hsa051400.54335611
52Fatty acid elongation_Homo sapiens_hsa000620.52991125
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50400144
54Endocytosis_Homo sapiens_hsa041440.49884852
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49645455
56Viral carcinogenesis_Homo sapiens_hsa052030.48096623
57Prion diseases_Homo sapiens_hsa050200.48063721
58Parkinsons disease_Homo sapiens_hsa050120.47492704
59Legionellosis_Homo sapiens_hsa051340.47401240
60Malaria_Homo sapiens_hsa051440.45346421
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44065328
62B cell receptor signaling pathway_Homo sapiens_hsa046620.43975636
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.43852448
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41179942
65Nucleotide excision repair_Homo sapiens_hsa034200.39135105
66Phototransduction_Homo sapiens_hsa047440.38309833
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37650115
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37168107
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30155021
70Olfactory transduction_Homo sapiens_hsa047400.28179727
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.27198709
72Toxoplasmosis_Homo sapiens_hsa051450.26048777
73Tuberculosis_Homo sapiens_hsa051520.21785261
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.20880210
75Butanoate metabolism_Homo sapiens_hsa006500.20324402
76Ether lipid metabolism_Homo sapiens_hsa005650.20241329
77Alzheimers disease_Homo sapiens_hsa050100.19732774
78Dorso-ventral axis formation_Homo sapiens_hsa043200.19645256
79p53 signaling pathway_Homo sapiens_hsa041150.19520088
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.18976592
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18975860
82Arachidonic acid metabolism_Homo sapiens_hsa005900.17819465
83Hepatitis C_Homo sapiens_hsa051600.15845525
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15388330
85Pertussis_Homo sapiens_hsa051330.15289430
86Lysosome_Homo sapiens_hsa041420.15271208
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14097892
88Collecting duct acid secretion_Homo sapiens_hsa049660.12169159
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12163376
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.10393218
91Retinol metabolism_Homo sapiens_hsa008300.09527107
92Homologous recombination_Homo sapiens_hsa034400.09025861
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08102931
94Purine metabolism_Homo sapiens_hsa002300.07849499
95Pyrimidine metabolism_Homo sapiens_hsa002400.07836245
96Peroxisome_Homo sapiens_hsa041460.06585252
97African trypanosomiasis_Homo sapiens_hsa051430.06253378
98Mineral absorption_Homo sapiens_hsa049780.05397759
99Phagosome_Homo sapiens_hsa041450.05175910
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.04435997

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