ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	4.56662811
2	fucose catabolic process (GO:0019317)	3.66582912
3	L-fucose metabolic process (GO:0042354)	3.66582912
4	L-fucose catabolic process (GO:0042355)	3.66582912
5	cellular response to interleukin-15 (GO:0071350)	3.66066364
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.56370805
7	cytidine deamination (GO:0009972)	3.42665727
8	cytidine metabolic process (GO:0046087)	3.42665727
9	cytidine catabolic process (GO:0006216)	3.42665727
10	positive regulation of defense response to virus by host (GO:0002230)	3.41469707
11	tryptophan catabolic process (GO:0006569)	3.38748180
12	indole-containing compound catabolic process (GO:0042436)	3.38748180
13	indolalkylamine catabolic process (GO:0046218)	3.38748180
14	platelet dense granule organization (GO:0060155)	3.28649597
15	positive regulation of B cell differentiation (GO:0045579)	3.28581141
16	regulation of B cell receptor signaling pathway (GO:0050855)	3.23634254
17	indolalkylamine metabolic process (GO:0006586)	3.19728409
18	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.14522142
19	negative regulation of mast cell activation (GO:0033004)	3.11722928
20	response to interleukin-15 (GO:0070672)	3.04600281
21	tryptophan metabolic process (GO:0006568)	3.03966019
22	respiratory chain complex IV assembly (GO:0008535)	3.03868247
23	kynurenine metabolic process (GO:0070189)	2.98775611
24	positive regulation of interleukin-17 production (GO:0032740)	2.98435634
25	cellular ketone body metabolic process (GO:0046950)	2.97392551
26	succinate metabolic process (GO:0006105)	2.93810400
27	regulation of cilium movement (GO:0003352)	2.89302880
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.88798790
29	NADH dehydrogenase complex assembly (GO:0010257)	2.88798790
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.88798790
31	neural tube formation (GO:0001841)	2.88739038
32	response to pheromone (GO:0019236)	2.86600576
33	protein complex biogenesis (GO:0070271)	2.84660193
34	mannosylation (GO:0097502)	2.84506610
35	signal peptide processing (GO:0006465)	2.82867653
36	epithelial cilium movement (GO:0003351)	2.79406613
37	preassembly of GPI anchor in ER membrane (GO:0016254)	2.78016166
38	adaptation of signaling pathway (GO:0023058)	2.77883032
39	positive regulation of natural killer cell differentiation (GO:0032825)	2.75652186
40	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75384033
41	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.73994956
42	detection of light stimulus involved in sensory perception (GO:0050962)	2.73978137
43	detection of light stimulus involved in visual perception (GO:0050908)	2.73978137
44	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.73819965
45	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.71153264
46	proteasome assembly (GO:0043248)	2.71060833
47	behavioral response to nicotine (GO:0035095)	2.69889142
48	cytochrome complex assembly (GO:0017004)	2.69406432
49	amine catabolic process (GO:0009310)	2.68609114
50	cellular biogenic amine catabolic process (GO:0042402)	2.68609114
51	DNA double-strand break processing (GO:0000729)	2.67096796
52	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66998250
53	DNA demethylation (GO:0080111)	2.66400694
54	ketone body metabolic process (GO:1902224)	2.64210219
55	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.62543651
56	regulation of chronic inflammatory response (GO:0002676)	2.61010463
57	proline transport (GO:0015824)	2.60712708
58	dopamine transport (GO:0015872)	2.59450448
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.56618598
60	protein K6-linked ubiquitination (GO:0085020)	2.56540652
61	regulation of B cell differentiation (GO:0045577)	2.54264202
62	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.53485437
63	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.52230266
64	protein-cofactor linkage (GO:0018065)	2.47660577
65	recombinational repair (GO:0000725)	2.46508001
66	double-strand break repair via homologous recombination (GO:0000724)	2.45879733
67	cell wall macromolecule catabolic process (GO:0016998)	2.45630858
68	regulation of memory T cell differentiation (GO:0043380)	2.45509569
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.43051833
70	methionine biosynthetic process (GO:0009086)	2.41886408
71	amino acid salvage (GO:0043102)	2.41151607
72	L-methionine salvage (GO:0071267)	2.41151607
73	L-methionine biosynthetic process (GO:0071265)	2.41151607
74	sulfation (GO:0051923)	2.40114766
75	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	2.39911395
76	positive regulation of protein homodimerization activity (GO:0090073)	2.39843730
77	replication fork processing (GO:0031297)	2.35583702
78	positive regulation of T-helper 1 type immune response (GO:0002827)	2.34448785
79	regulation of defense response to virus by host (GO:0050691)	2.30612063
80	axoneme assembly (GO:0035082)	2.30577678
81	S-adenosylmethionine metabolic process (GO:0046500)	2.30301967
82	piRNA metabolic process (GO:0034587)	2.29707160
83	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.28384760
84	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.27932441
85	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.27864178
86	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.27864178
87	ubiquinone biosynthetic process (GO:0006744)	2.27489275
88	positive regulation of prostaglandin secretion (GO:0032308)	2.26118827
89	interferon-gamma production (GO:0032609)	2.25181287
90	retinal cone cell development (GO:0046549)	2.25119499
91	positive regulation of mitochondrial fission (GO:0090141)	2.25035510
92	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.24097548
93	cilium movement (GO:0003341)	2.23259568
94	reciprocal DNA recombination (GO:0035825)	2.21408385
95	reciprocal meiotic recombination (GO:0007131)	2.21408385
96	indole-containing compound metabolic process (GO:0042430)	2.21308092
97	anterograde synaptic vesicle transport (GO:0048490)	2.21253254
98	T cell migration (GO:0072678)	2.19884948
99	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.19783118
100	water-soluble vitamin biosynthetic process (GO:0042364)	2.18761352

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.16654844
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.05293733
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.01579501
4	VDR_22108803_ChIP-Seq_LS180_Human	2.83241221
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.58531896
6	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.35182748
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.32214833
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.27966089
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.23308694
10	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.21561866
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.20766314
12	GBX2_23144817_ChIP-Seq_PC3_Human	2.20487429
13	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.14737218
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.03503394
15	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.00824201
16	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.99131473
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.90883603
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.89142699
19	TAF15_26573619_Chip-Seq_HEK293_Human	1.88033439
20	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.87424868
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.85113040
22	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.83286396
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.81808707
24	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.81585644
25	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76850053
26	GATA1_22025678_ChIP-Seq_K562_Human	1.76493428
27	EWS_26573619_Chip-Seq_HEK293_Human	1.72514571
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.67158147
29	P300_19829295_ChIP-Seq_ESCs_Human	1.66706565
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66095734
31	ELK1_19687146_ChIP-ChIP_HELA_Human	1.62851235
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.59952105
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56930950
34	FUS_26573619_Chip-Seq_HEK293_Human	1.54625477
35	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.53918299
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53583263
37	EZH2_22144423_ChIP-Seq_EOC_Human	1.50817355
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.46126075
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.45759764
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45584957
41	GATA3_26560356_Chip-Seq_TH2_Human	1.43481811
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.40365754
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40365754
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.39973422
45	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36806006
46	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.35535397
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34426578
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31638892
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31224615
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29974121
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29974121
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.29947963
53	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29010532
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28930291
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27218324
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27218324
57	FOXP3_21729870_ChIP-Seq_TREG_Human	1.27184498
58	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.24968708
59	* TCF4_23295773_ChIP-Seq_U87_Human	1.24839417
60	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.24380267
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24180644
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24180644
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.24175776
64	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.23953988
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21573133
66	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.21151427
67	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.21119033
68	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21093625
69	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.20997226
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.20982853
71	STAT3_23295773_ChIP-Seq_U87_Human	1.20917017
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.18151540
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.18110542
74	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15944604
75	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13583754
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12912259
77	AR_20517297_ChIP-Seq_VCAP_Human	1.12883760
78	AR_25329375_ChIP-Seq_VCAP_Human	1.12875718
79	NCOR_22424771_ChIP-Seq_293T_Human	1.12232867
80	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.11831443
81	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.11283579
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.10471929
83	MYB_26560356_Chip-Seq_TH2_Human	1.10467603
84	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09749818
85	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09638600
86	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.09241837
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.09037163
88	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06341851
89	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.04476759
90	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.04350561
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04052822
92	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.03726509
93	GATA3_27048872_Chip-Seq_THYMUS_Human	1.03150426
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.00644318
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.99362767
96	RUNX_20019798_ChIP-Seq_JUKART_Human	0.98163074
97	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97523811
98	SMRT_27268052_Chip-Seq_Bcells_Human	0.96497784
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95605565
100	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95554075

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	3.20177671
2	MP0003195_calcinosis	2.62578169
3	MP0008877_abnormal_DNA_methylation	2.58279637
4	MP0001835_abnormal_antigen_presentation	2.56124023
5	MP0005645_abnormal_hypothalamus_physiol	2.29006854
6	MP0000569_abnormal_digit_pigmentation	2.16833346
7	MP0009046_muscle_twitch	2.03359674
8	MP0001800_abnormal_humoral_immune	1.98293959
9	MP0009785_altered_susceptibility_to	1.96439321
10	MP0002837_dystrophic_cardiac_calcinosis	1.95296307
11	MP0001790_abnormal_immune_system	1.93299189
12	MP0005387_immune_system_phenotype	1.93299189
13	MP0002102_abnormal_ear_morphology	1.91287256
14	MP0003787_abnormal_imprinting	1.90469117
15	MP0001501_abnormal_sleep_pattern	1.86687101
16	MP0008872_abnormal_physiological_respon	1.85968231
17	MP0000372_irregular_coat_pigmentation	1.83802323
18	MP0005551_abnormal_eye_electrophysiolog	1.82360245
19	MP0004147_increased_porphyrin_level	1.80240774
20	MP0000685_abnormal_immune_system	1.70176205
21	MP0002148_abnormal_hypersensitivity_rea	1.70092021
22	MP0001968_abnormal_touch/_nociception	1.65398764
23	MP0003646_muscle_fatigue	1.64448054
24	MP0006082_CNS_inflammation	1.62582125
25	MP0009764_decreased_sensitivity_to	1.60431419
26	MP0002723_abnormal_immune_serum	1.55440974
27	MP0002452_abnormal_antigen_presenting	1.52207657
28	MP0008875_abnormal_xenobiotic_pharmacok	1.52083581
29	MP0006036_abnormal_mitochondrial_physio	1.52043551
30	MP0005000_abnormal_immune_tolerance	1.49436517
31	MP0004043_abnormal_pH_regulation	1.49435138
32	MP0005310_abnormal_salivary_gland	1.49301173
33	MP0005253_abnormal_eye_physiology	1.47529085
34	MP0009745_abnormal_behavioral_response	1.42711574
35	MP0001986_abnormal_taste_sensitivity	1.42647705
36	MP0002138_abnormal_hepatobiliary_system	1.42317621
37	MP0006072_abnormal_retinal_apoptosis	1.42106828
38	MP0005075_abnormal_melanosome_morpholog	1.40541201
39	MP0004142_abnormal_muscle_tone	1.40433166
40	MP0002420_abnormal_adaptive_immunity	1.38959526
41	MP0003724_increased_susceptibility_to	1.38008677
42	MP0003011_delayed_dark_adaptation	1.35808112
43	MP0001819_abnormal_immune_cell	1.34746256
44	MP0003045_fibrosis	1.30341681
45	MP0005646_abnormal_pituitary_gland	1.30091243
46	MP0003763_abnormal_thymus_physiology	1.28079608
47	MP0002876_abnormal_thyroid_physiology	1.25868663
48	MP0001905_abnormal_dopamine_level	1.25831363
49	MP0006035_abnormal_mitochondrial_morpho	1.22557738
50	MP0002736_abnormal_nociception_after	1.21012746
51	MP0008995_early_reproductive_senescence	1.19837107
52	MP0004145_abnormal_muscle_electrophysio	1.18612859
53	MP0005025_abnormal_response_to	1.18255924
54	MP0001764_abnormal_homeostasis	1.16721980
55	MP0010386_abnormal_urinary_bladder	1.15594672
56	MP0002693_abnormal_pancreas_physiology	1.15361644
57	MP0002272_abnormal_nervous_system	1.12165975
58	MP0005084_abnormal_gallbladder_morpholo	1.10491897
59	MP0000689_abnormal_spleen_morphology	1.10002926
60	MP0001873_stomach_inflammation	1.08186290
61	MP0003806_abnormal_nucleotide_metabolis	1.07864417
62	MP0004742_abnormal_vestibular_system	1.07849500
63	MP0005167_abnormal_blood-brain_barrier	1.05950713
64	MP0001845_abnormal_inflammatory_respons	1.05635359
65	MP0000716_abnormal_immune_system	1.03241479
66	MP0000427_abnormal_hair_cycle	1.01827795
67	MP0001485_abnormal_pinna_reflex	1.01732507
68	MP0002928_abnormal_bile_duct	1.01062362
69	MP0002163_abnormal_gland_morphology	0.99332964
70	MP0002332_abnormal_exercise_endurance	0.97716915
71	MP0002398_abnormal_bone_marrow	0.97471442
72	MP0002405_respiratory_system_inflammati	0.96579199
73	MP0005174_abnormal_tail_pigmentation	0.95701117
74	MP0005410_abnormal_fertilization	0.94175723
75	MP0005332_abnormal_amino_acid	0.94098461
76	MP0004924_abnormal_behavior	0.93020058
77	MP0005386_behavior/neurological_phenoty	0.93020058
78	MP0001529_abnormal_vocalization	0.92434607
79	MP0005389_reproductive_system_phenotype	0.92057791
80	MP0001919_abnormal_reproductive_system	0.91917656
81	MP0002638_abnormal_pupillary_reflex	0.91550856
82	MP0001984_abnormal_olfaction	0.91365842
83	MP0002277_abnormal_respiratory_mucosa	0.90774606
84	MP0002419_abnormal_innate_immunity	0.90719982
85	MP0001486_abnormal_startle_reflex	0.89739509
86	MP0002064_seizures	0.86950766
87	MP0003866_abnormal_defecation	0.86406055
88	MP0000631_abnormal_neuroendocrine_gland	0.86210155
89	MP0005379_endocrine/exocrine_gland_phen	0.85974954
90	MP0002735_abnormal_chemical_nociception	0.85741497
91	MP0008469_abnormal_protein_level	0.84631142
92	MP0009333_abnormal_splenocyte_physiolog	0.84454947
93	MP0002229_neurodegeneration	0.81424402
94	MP0003786_premature_aging	0.80415549
95	MP0005085_abnormal_gallbladder_physiolo	0.79095120
96	MP0001970_abnormal_pain_threshold	0.78690881
97	MP0003718_maternal_effect	0.77340688
98	MP0005266_abnormal_metabolism	0.76799560
99	MP0003252_abnormal_bile_duct	0.76169319
100	MP0002572_abnormal_emotion/affect_behav	0.75898498

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.59785987
2	Pancreatic cysts (HP:0001737)	4.10480968
3	Pancreatic fibrosis (HP:0100732)	3.61836180
4	True hermaphroditism (HP:0010459)	3.55628730
5	Methylmalonic aciduria (HP:0012120)	3.34764542
6	Molar tooth sign on MRI (HP:0002419)	3.34139419
7	Abnormality of midbrain morphology (HP:0002418)	3.34139419
8	Congenital stationary night blindness (HP:0007642)	3.17070879
9	Attenuation of retinal blood vessels (HP:0007843)	3.00920042
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.86050457
11	Abolished electroretinogram (ERG) (HP:0000550)	2.82905242
12	Nephronophthisis (HP:0000090)	2.80111622
13	Abnormal rod and cone electroretinograms (HP:0008323)	2.69108848
14	Acute necrotizing encephalopathy (HP:0006965)	2.67814286
15	Chronic hepatic failure (HP:0100626)	2.65397066
16	Abnormal biliary tract physiology (HP:0012439)	2.63802272
17	Bile duct proliferation (HP:0001408)	2.63802272
18	Chronic diarrhea (HP:0002028)	2.63538636
19	Mitochondrial inheritance (HP:0001427)	2.63183320
20	Medial flaring of the eyebrow (HP:0010747)	2.61118486
21	Abnormality of the renal cortex (HP:0011035)	2.60873882
22	Gaze-evoked nystagmus (HP:0000640)	2.57354022
23	Stomatitis (HP:0010280)	2.56126009
24	3-Methylglutaconic aciduria (HP:0003535)	2.56121526
25	Increased CSF lactate (HP:0002490)	2.54520607
26	Abnormality of the renal medulla (HP:0100957)	2.43674334
27	Decreased central vision (HP:0007663)	2.42967089
28	Progressive macrocephaly (HP:0004481)	2.41857769
29	Acute encephalopathy (HP:0006846)	2.39808442
30	Type II lissencephaly (HP:0007260)	2.37300619
31	Cystic liver disease (HP:0006706)	2.29757548
32	IgG deficiency (HP:0004315)	2.28543101
33	Abnormal mitochondria in muscle tissue (HP:0008316)	2.28515270
34	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.26829985
35	Hepatic necrosis (HP:0002605)	2.24185338
36	Hypothermia (HP:0002045)	2.23887022
37	Thyroiditis (HP:0100646)	2.21942638
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.21677816
39	Inability to walk (HP:0002540)	2.21355101
40	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18488401
41	Abnormality of alanine metabolism (HP:0010916)	2.18488401
42	Hyperalaninemia (HP:0003348)	2.18488401
43	Large for gestational age (HP:0001520)	2.17812197
44	Progressive inability to walk (HP:0002505)	2.17117983
45	Renal cortical cysts (HP:0000803)	2.13990768
46	Hepatocellular necrosis (HP:0001404)	2.13728411
47	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.11612834
48	Dicarboxylic aciduria (HP:0003215)	2.11612834
49	Severe combined immunodeficiency (HP:0004430)	2.08331623
50	Ketoacidosis (HP:0001993)	2.06700658
51	Abnormality of T cells (HP:0002843)	2.04082502
52	Gait imbalance (HP:0002141)	2.02423597
53	Abnormality of T cell number (HP:0011839)	2.02404997
54	Ketosis (HP:0001946)	2.01658558
55	Abnormality of T cell physiology (HP:0011840)	2.01354379
56	Congenital primary aphakia (HP:0007707)	2.01353327
57	Polydipsia (HP:0001959)	2.00966674
58	Abnormal drinking behavior (HP:0030082)	2.00966674
59	Optic neuritis (HP:0100653)	2.00452791
60	Retrobulbar optic neuritis (HP:0100654)	2.00452791
61	Furrowed tongue (HP:0000221)	1.99758417
62	Panhypogammaglobulinemia (HP:0003139)	1.97311357
63	Congenital hepatic fibrosis (HP:0002612)	1.97293070
64	T lymphocytopenia (HP:0005403)	1.96927993
65	Nephrogenic diabetes insipidus (HP:0009806)	1.96289909
66	Optic disc pallor (HP:0000543)	1.95638447
67	Lactic acidosis (HP:0003128)	1.95178653
68	Methylmalonic acidemia (HP:0002912)	1.94829731
69	Lipid accumulation in hepatocytes (HP:0006561)	1.90427065
70	Abnormality of B cell number (HP:0010975)	1.89855392
71	Abnormal protein glycosylation (HP:0012346)	1.89609757
72	Abnormal glycosylation (HP:0012345)	1.89609757
73	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.89609757
74	Abnormal protein N-linked glycosylation (HP:0012347)	1.89609757
75	Recurrent sinusitis (HP:0011108)	1.87025251
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.86028549
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.86028549
78	Febrile seizures (HP:0002373)	1.85961490
79	Male pseudohermaphroditism (HP:0000037)	1.84252082
80	Increased serum lactate (HP:0002151)	1.83580274
81	Chronic mucocutaneous candidiasis (HP:0002728)	1.83431085
82	Recurrent cutaneous fungal infections (HP:0011370)	1.83431085
83	Absent speech (HP:0001344)	1.83370337
84	Pendular nystagmus (HP:0012043)	1.82258114
85	Absent/shortened dynein arms (HP:0200106)	1.81983769
86	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81983769
87	Autoimmune thrombocytopenia (HP:0001973)	1.78922247
88	Anencephaly (HP:0002323)	1.77870390
89	Respiratory failure (HP:0002878)	1.77072390
90	Tubular atrophy (HP:0000092)	1.75908389
91	Abnormality of the prostate (HP:0008775)	1.75871691
92	Bony spicule pigmentary retinopathy (HP:0007737)	1.75708846
93	Constricted visual fields (HP:0001133)	1.75463882
94	Decreased circulating renin level (HP:0003351)	1.72468775
95	Cerebellar dysplasia (HP:0007033)	1.72172187
96	Sclerocornea (HP:0000647)	1.71255037
97	Generalized aminoaciduria (HP:0002909)	1.70980455
98	Elevated erythrocyte sedimentation rate (HP:0003565)	1.69961452
99	Abnormality of macular pigmentation (HP:0008002)	1.69048084
100	Encephalitis (HP:0002383)	1.67878301

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.26776500
2	TAOK3	3.05633324
3	TXK	3.02023667
4	ZAK	2.85938922
5	ADRBK2	2.84711952
6	PINK1	2.56898912
7	MST4	2.56404251
8	MAP4K2	2.55162252
9	NUAK1	2.20782519
10	TLK1	2.12997614
11	GRK1	2.09116115
12	MAP3K4	2.03395743
13	EIF2AK3	1.98560006
14	BMPR1B	1.86371207
15	ACVR1B	1.82304071
16	WNK3	1.78632924
17	INSRR	1.69831901
18	MAPK13	1.61293121
19	MAP4K1	1.37336410
20	BCKDK	1.36189344
21	TEC	1.30127988
22	STK16	1.24115695
23	CSNK1G3	1.22723636
24	TNK2	1.18556613
25	VRK1	1.16766090
26	TRIM28	1.16292223
27	IKBKB	1.14804470
28	OXSR1	1.13585010
29	GRK7	1.13382404
30	CSNK1G2	1.13118872
31	CSNK1G1	1.12958295
32	ITK	1.12092983
33	JAK3	1.11078124
34	SYK	1.08188161
35	CSNK1A1L	1.07524667
36	PAK3	1.06920604
37	PRKCQ	1.06834024
38	DAPK2	1.06180936
39	WNK4	1.02985015
40	KIT	0.94992730
41	NME1	0.93620936
42	IRAK4	0.93471134
43	BMPR2	0.90736124
44	ADRBK1	0.89727435
45	IKBKE	0.86583718
46	EIF2AK1	0.85609723
47	LYN	0.80366670
48	PRKCE	0.78670642
49	PIK3CG	0.76738427
50	CAMKK2	0.76236585
51	CASK	0.76222743
52	MAP2K7	0.76186354
53	MARK3	0.75642762
54	BTK	0.75429670
55	CCNB1	0.74763565
56	BLK	0.70992200
57	MAP3K12	0.70795897
58	RPS6KA5	0.69161736
59	STK39	0.68574058
60	MAP2K6	0.67861116
61	FES	0.66618908
62	PDK2	0.65455471
63	MAP3K14	0.60319101
64	IRAK1	0.59751995
65	LCK	0.59093577
66	CDK19	0.58366355
67	BCR	0.58296302
68	CSF1R	0.54456665
69	MAPKAPK3	0.54422098
70	MKNK2	0.53863495
71	KDR	0.53409303
72	VRK2	0.53360959
73	MUSK	0.53226220
74	TRPM7	0.53198320
75	TYK2	0.53194543
76	GRK5	0.52627440
77	DYRK2	0.52068681
78	CHUK	0.51890426
79	JAK1	0.51459794
80	EIF2AK2	0.50040568
81	PKN1	0.48590154
82	RIPK4	0.47592256
83	CDK8	0.46261798
84	PLK2	0.46046801
85	MARK1	0.45497762
86	PRKCG	0.45031575
87	NLK	0.45005055
88	ABL1	0.44760836
89	HCK	0.44155120
90	TBK1	0.40923495
91	CSNK1A1	0.39602978
92	OBSCN	0.39190159
93	IGF1R	0.38743285
94	PTK2B	0.38636800
95	ERBB3	0.38157301
96	TIE1	0.37876409
97	PHKG1	0.36580451
98	PHKG2	0.36580451
99	JAK2	0.36265874
100	MAPKAPK5	0.36166465

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.95229611
2	Asthma_Homo sapiens_hsa05310	2.82524420
3	Primary immunodeficiency_Homo sapiens_hsa05340	2.74533027
4	Allograft rejection_Homo sapiens_hsa05330	2.65126579
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.61468200
6	Proteasome_Homo sapiens_hsa03050	2.61061054
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.47120114
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.45009941
9	Protein export_Homo sapiens_hsa03060	2.35456247
10	Parkinsons disease_Homo sapiens_hsa05012	2.19629448
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.17722307
12	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14000115
13	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.11363929
14	Phototransduction_Homo sapiens_hsa04744	2.05935119
15	Butanoate metabolism_Homo sapiens_hsa00650	2.02864246
16	Propanoate metabolism_Homo sapiens_hsa00640	2.02830857
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.96561059
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.95026491
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.73400013
20	RNA polymerase_Homo sapiens_hsa03020	1.69175831
21	Rheumatoid arthritis_Homo sapiens_hsa05323	1.63089192
22	Homologous recombination_Homo sapiens_hsa03440	1.57541738
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.56422359
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48516009
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.46727707
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.43541251
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.42285958
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41789421
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.35867043
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.34587413
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34569643
32	Basal transcription factors_Homo sapiens_hsa03022	1.30440736
33	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.28597243
34	Antigen processing and presentation_Homo sapiens_hsa04612	1.27728142
35	Alzheimers disease_Homo sapiens_hsa05010	1.26213173
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.26136093
37	Huntingtons disease_Homo sapiens_hsa05016	1.24928014
38	Collecting duct acid secretion_Homo sapiens_hsa04966	1.24080588
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.21089083
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20818670
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.16555706
42	Peroxisome_Homo sapiens_hsa04146	1.05685196
43	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02915585
44	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.00516594
45	Regulation of autophagy_Homo sapiens_hsa04140	0.99847076
46	Olfactory transduction_Homo sapiens_hsa04740	0.99427694
47	RNA degradation_Homo sapiens_hsa03018	0.94167982
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.92500798
49	Caffeine metabolism_Homo sapiens_hsa00232	0.91168810
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.91155580
51	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.88889722
52	Taste transduction_Homo sapiens_hsa04742	0.86319594
53	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.86016397
54	One carbon pool by folate_Homo sapiens_hsa00670	0.85469755
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82478577
56	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.81562665
57	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.80154632
58	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.79676317
59	Sulfur metabolism_Homo sapiens_hsa00920	0.74937713
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74710354
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.69504170
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69284480
63	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.68212925
64	Nicotine addiction_Homo sapiens_hsa05033	0.67666107
65	Measles_Homo sapiens_hsa05162	0.67146603
66	Leishmaniasis_Homo sapiens_hsa05140	0.66650497
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64363971
68	Purine metabolism_Homo sapiens_hsa00230	0.59280380
69	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.58915098
70	Morphine addiction_Homo sapiens_hsa05032	0.57191298
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55558536
72	Viral myocarditis_Homo sapiens_hsa05416	0.54993288
73	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54914886
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.54276449
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.53403438
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51903837
77	Tuberculosis_Homo sapiens_hsa05152	0.51341507
78	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.50511973
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49812827
80	ABC transporters_Homo sapiens_hsa02010	0.49497742
81	Retinol metabolism_Homo sapiens_hsa00830	0.45950575
82	Metabolic pathways_Homo sapiens_hsa01100	0.43715962
83	Nucleotide excision repair_Homo sapiens_hsa03420	0.43395772
84	Herpes simplex infection_Homo sapiens_hsa05168	0.41164850
85	Mineral absorption_Homo sapiens_hsa04978	0.40073793
86	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38886580
87	Salivary secretion_Homo sapiens_hsa04970	0.36015370
88	GABAergic synapse_Homo sapiens_hsa04727	0.35280094
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35257135
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.35146424
91	Circadian entrainment_Homo sapiens_hsa04713	0.34460122
92	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34415148
93	Serotonergic synapse_Homo sapiens_hsa04726	0.31967621
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.31727755
95	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30527534
96	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.30078179
97	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29806137
98	Fatty acid elongation_Homo sapiens_hsa00062	0.29165963
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28832562
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.27458683

C15ORF57

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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