C15ORF59

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.28276782
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.83776091
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.55385565
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.46802899
5postsynaptic membrane organization (GO:0001941)5.34204812
6glutamate secretion (GO:0014047)4.96880979
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.81543079
8synaptic vesicle exocytosis (GO:0016079)4.69685236
9neurotransmitter secretion (GO:0007269)4.51515015
10vocalization behavior (GO:0071625)4.48406131
11neuronal action potential propagation (GO:0019227)4.47283766
12cellular potassium ion homeostasis (GO:0030007)4.46153416
13regulation of synaptic vesicle exocytosis (GO:2000300)4.42841444
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35596634
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.33696174
16central nervous system myelination (GO:0022010)4.31457069
17axon ensheathment in central nervous system (GO:0032291)4.31457069
18regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.25060142
19negative regulation of synaptic transmission, GABAergic (GO:0032229)4.23284824
20neuron cell-cell adhesion (GO:0007158)4.22017066
21gamma-aminobutyric acid transport (GO:0015812)4.19379532
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.19189625
23regulation of synapse structural plasticity (GO:0051823)4.15434181
24locomotory exploration behavior (GO:0035641)4.12484325
25regulation of synaptic vesicle transport (GO:1902803)4.12090917
26dendritic spine morphogenesis (GO:0060997)4.10107710
27synaptic transmission, glutamatergic (GO:0035249)4.04233117
28protein localization to synapse (GO:0035418)4.02927152
29presynaptic membrane assembly (GO:0097105)3.96109438
30presynaptic membrane organization (GO:0097090)3.88199874
31transmission of nerve impulse (GO:0019226)3.87168741
32exploration behavior (GO:0035640)3.85135829
33auditory behavior (GO:0031223)3.83394090
34regulation of neuronal synaptic plasticity (GO:0048168)3.78120193
35neurotransmitter-gated ion channel clustering (GO:0072578)3.78052414
36potassium ion import (GO:0010107)3.75597363
37glutamate receptor signaling pathway (GO:0007215)3.74323319
38behavioral response to nicotine (GO:0035095)3.72237431
39sodium ion export (GO:0071436)3.69098376
40regulation of glutamate receptor signaling pathway (GO:1900449)3.67403035
41membrane depolarization during action potential (GO:0086010)3.67233023
42neurotransmitter transport (GO:0006836)3.66903263
43regulation of neurotransmitter levels (GO:0001505)3.64658065
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57439973
45neuron-neuron synaptic transmission (GO:0007270)3.53867898
46regulation of voltage-gated calcium channel activity (GO:1901385)3.49219765
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45388910
48L-amino acid import (GO:0043092)3.42686339
49regulation of long-term neuronal synaptic plasticity (GO:0048169)3.39933667
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36777305
51potassium ion homeostasis (GO:0055075)3.34670607
52neurotransmitter uptake (GO:0001504)3.33623129
53regulation of neurotransmitter secretion (GO:0046928)3.32841630
54neuromuscular synaptic transmission (GO:0007274)3.31869369
55positive regulation of membrane potential (GO:0045838)3.28860691
56regulation of neurotransmitter transport (GO:0051588)3.27781484
57membrane depolarization (GO:0051899)3.27276660
58positive regulation of dendritic spine development (GO:0060999)3.27119878
59positive regulation of synapse maturation (GO:0090129)3.26783294
60cerebellar granule cell differentiation (GO:0021707)3.22156729
61detection of calcium ion (GO:0005513)3.21942864
62regulation of postsynaptic membrane potential (GO:0060078)3.21613428
63proline transport (GO:0015824)3.18828674
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.18647731
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18311739
66C4-dicarboxylate transport (GO:0015740)3.13986546
67mechanosensory behavior (GO:0007638)3.11570969
68neuronal ion channel clustering (GO:0045161)3.10716128
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09658585
70cell communication by electrical coupling (GO:0010644)3.06733754
71startle response (GO:0001964)3.05200942
72response to auditory stimulus (GO:0010996)3.04430151
73regulation of respiratory system process (GO:0044065)2.98963904
74G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.97458367
75regulation of dendritic spine development (GO:0060998)2.96727344
76synaptic transmission (GO:0007268)2.96483415
77regulation of synapse maturation (GO:0090128)2.90991068
78regulation of synaptic transmission, glutamatergic (GO:0051966)2.90082788
79regulation of neurotransmitter uptake (GO:0051580)2.90077994
80regulation of dendritic spine morphogenesis (GO:0061001)2.89855899
81cell migration in hindbrain (GO:0021535)2.89524329
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89400687
83cerebellar Purkinje cell differentiation (GO:0021702)2.89156061
84acidic amino acid transport (GO:0015800)2.87457145
85negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83593294
86neuronal action potential (GO:0019228)2.83487789
87serotonin metabolic process (GO:0042428)2.82955401
88amino acid import (GO:0043090)2.82509639
89regulation of vesicle fusion (GO:0031338)2.80500986
90axonal fasciculation (GO:0007413)2.79186052
91multicellular organismal signaling (GO:0035637)2.77790626
92potassium ion transmembrane transport (GO:0071805)2.77638867
93cellular potassium ion transport (GO:0071804)2.77638867
94neuromuscular process controlling balance (GO:0050885)2.77388342
95cellular sodium ion homeostasis (GO:0006883)2.76345138
96adult walking behavior (GO:0007628)2.76241504
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.75355115
98synapse assembly (GO:0007416)2.75189450
99behavioral fear response (GO:0001662)2.73530249
100behavioral defense response (GO:0002209)2.73530249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77155646
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.26964421
3GBX2_23144817_ChIP-Seq_PC3_Human3.08327610
4REST_21632747_ChIP-Seq_MESCs_Mouse2.96807868
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.84700060
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73571298
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67075427
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.55886265
9DROSHA_22980978_ChIP-Seq_HELA_Human2.51000602
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44123298
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.37130975
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.35685673
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.30048947
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.29797800
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29688259
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29688259
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.28522662
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26557499
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25338554
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24958100
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.21183960
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19427542
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17500202
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11372522
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.95324722
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91549914
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86259798
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80744940
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79840193
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.75347189
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70093927
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69366601
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67029877
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64202988
35ZNF274_21170338_ChIP-Seq_K562_Hela1.63353653
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55776939
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54457001
38RNF2_27304074_Chip-Seq_NSC_Mouse1.53471601
39AR_21572438_ChIP-Seq_LNCaP_Human1.52160261
40VDR_22108803_ChIP-Seq_LS180_Human1.49910166
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.49140642
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47965278
43TAF15_26573619_Chip-Seq_HEK293_Human1.39282951
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.38456850
45SMAD4_21799915_ChIP-Seq_A2780_Human1.34325924
46IGF1R_20145208_ChIP-Seq_DFB_Human1.33953374
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.28332031
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28220623
49P300_19829295_ChIP-Seq_ESCs_Human1.27608450
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23743988
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23627171
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18438498
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18438498
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.17519477
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17355043
56STAT3_23295773_ChIP-Seq_U87_Human1.14012925
57* TCF4_23295773_ChIP-Seq_U87_Human1.13964527
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12469959
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.11506383
60MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10837232
61AR_25329375_ChIP-Seq_VCAP_Human1.09158073
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08418984
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08247154
64AR_19668381_ChIP-Seq_PC3_Human1.06466160
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06092815
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.05485161
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00845328
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00393634
69WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98949476
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97934649
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96776172
72BCAT_22108803_ChIP-Seq_LS180_Human0.96705304
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96689446
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.96068380
75NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95692694
76MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95525549
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95150199
78NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94564822
79SMAD3_21741376_ChIP-Seq_ESCs_Human0.94172324
80RING1B_27294783_Chip-Seq_NPCs_Mouse0.94136933
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92513610
82DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91380568
83CTCF_27219007_Chip-Seq_Bcells_Human0.91220358
84ER_23166858_ChIP-Seq_MCF-7_Human0.91018095
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.90338627
86* RUNX2_22187159_ChIP-Seq_PCA_Human0.89254142
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88656609
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87619574
89CBP_20019798_ChIP-Seq_JUKART_Human0.87619574
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87058682
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86285515
92PRDM14_20953172_ChIP-Seq_ESCs_Human0.86266936
93TP53_20018659_ChIP-ChIP_R1E_Mouse0.85693311
94FLI1_21867929_ChIP-Seq_TH2_Mouse0.85182765
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85179607
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84157722
97FUS_26573619_Chip-Seq_HEK293_Human0.84036732
98ETV2_25802403_ChIP-Seq_MESCs_Mouse0.83946312
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.82575645
100TCF4_22108803_ChIP-Seq_LS180_Human0.82308859

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.88925408
2MP0003880_abnormal_central_pattern4.37921220
3MP0003635_abnormal_synaptic_transmissio3.45418210
4MP0004270_analgesia3.32325020
5MP0005423_abnormal_somatic_nervous3.31928632
6MP0009745_abnormal_behavioral_response3.25759249
7MP0002064_seizures3.16799299
8MP0001968_abnormal_touch/_nociception3.15407633
9MP0002272_abnormal_nervous_system2.92462764
10MP0002063_abnormal_learning/memory/cond2.85861048
11MP0001486_abnormal_startle_reflex2.72907324
12MP0009046_muscle_twitch2.72002810
13MP0002734_abnormal_mechanical_nocicepti2.56960153
14MP0002572_abnormal_emotion/affect_behav2.55242875
15MP0002736_abnormal_nociception_after2.51470152
16MP0004885_abnormal_endolymph2.35618617
17MP0002735_abnormal_chemical_nociception2.22956637
18MP0001501_abnormal_sleep_pattern2.21988738
19MP0003787_abnormal_imprinting2.13235845
20MP0001970_abnormal_pain_threshold2.12349096
21MP0002733_abnormal_thermal_nociception2.06317263
22MP0006276_abnormal_autonomic_nervous1.95039864
23MP0005646_abnormal_pituitary_gland1.93816931
24MP0001984_abnormal_olfaction1.90003676
25MP0000778_abnormal_nervous_system1.80251846
26MP0002557_abnormal_social/conspecific_i1.76136367
27MP0002067_abnormal_sensory_capabilities1.75696529
28MP0009780_abnormal_chondrocyte_physiolo1.72175231
29MP0005551_abnormal_eye_electrophysiolog1.68294224
30MP0008569_lethality_at_weaning1.64699955
31MP0001502_abnormal_circadian_rhythm1.61727609
32MP0004924_abnormal_behavior1.56644462
33MP0005386_behavior/neurological_phenoty1.56644462
34MP0001440_abnormal_grooming_behavior1.55404573
35MP0003879_abnormal_hair_cell1.51502158
36MP0003329_amyloid_beta_deposits1.48713969
37MP0008877_abnormal_DNA_methylation1.48257816
38MP0002837_dystrophic_cardiac_calcinosis1.47758668
39MP0002638_abnormal_pupillary_reflex1.46079933
40MP0003136_yellow_coat_color1.37851051
41MP0000955_abnormal_spinal_cord1.37444713
42MP0003633_abnormal_nervous_system1.36670382
43MP0001905_abnormal_dopamine_level1.36592146
44MP0002882_abnormal_neuron_morphology1.32063139
45MP0001485_abnormal_pinna_reflex1.31942047
46MP0004142_abnormal_muscle_tone1.31924252
47MP0004742_abnormal_vestibular_system1.31584772
48MP0002184_abnormal_innervation1.29742085
49MP0002066_abnormal_motor_capabilities/c1.28996104
50MP0004811_abnormal_neuron_physiology1.28875733
51MP0003122_maternal_imprinting1.27579487
52MP0005167_abnormal_blood-brain_barrier1.24404297
53MP0008872_abnormal_physiological_respon1.22234134
54MP0005645_abnormal_hypothalamus_physiol1.21473272
55MP0003137_abnormal_impulse_conducting1.21457988
56MP0001529_abnormal_vocalization1.17660674
57MP0002653_abnormal_ependyma_morphology1.17413119
58MP0003283_abnormal_digestive_organ1.14936701
59MP0001986_abnormal_taste_sensitivity1.10823494
60MP0003631_nervous_system_phenotype1.10785454
61MP0004215_abnormal_myocardial_fiber1.09448332
62MP0001963_abnormal_hearing_physiology1.09138187
63MP0006292_abnormal_olfactory_placode1.07829342
64MP0002229_neurodegeneration1.05220358
65MP0000631_abnormal_neuroendocrine_gland1.02351329
66MP0002876_abnormal_thyroid_physiology1.02216096
67MP0004043_abnormal_pH_regulation1.01107766
68MP0001177_atelectasis1.00255094
69MP0002152_abnormal_brain_morphology0.99708677
70MP0000569_abnormal_digit_pigmentation0.98190885
71MP0010386_abnormal_urinary_bladder0.97595536
72MP0003690_abnormal_glial_cell0.97531481
73MP0002102_abnormal_ear_morphology0.96654096
74MP0000920_abnormal_myelination0.95797331
75MP0004130_abnormal_muscle_cell0.95791206
76MP0002909_abnormal_adrenal_gland0.94446258
77MP0002752_abnormal_somatic_nervous0.89985146
78MP0002234_abnormal_pharynx_morphology0.88491301
79MP0000026_abnormal_inner_ear0.87163450
80MP0005253_abnormal_eye_physiology0.83998214
81MP0004147_increased_porphyrin_level0.83359751
82MP0004145_abnormal_muscle_electrophysio0.82860475
83MP0004133_heterotaxia0.81213274
84MP0004085_abnormal_heartbeat0.80104553
85MP0006072_abnormal_retinal_apoptosis0.79413202
86MP0003632_abnormal_nervous_system0.77210040
87MP0002069_abnormal_eating/drinking_beha0.76101847
88MP0001188_hyperpigmentation0.74500932
89MP0002822_catalepsy0.74315126
90MP0003646_muscle_fatigue0.73056810
91MP0003634_abnormal_glial_cell0.70503883
92MP0003121_genomic_imprinting0.68581325
93MP0003123_paternal_imprinting0.67388528
94MP0000566_synostosis0.66267528
95MP0003938_abnormal_ear_development0.61874744
96MP0005535_abnormal_body_temperature0.59871062
97MP0001346_abnormal_lacrimal_gland0.57806382
98MP0005195_abnormal_posterior_eye0.55452393
99MP0004484_altered_response_of0.55194200
100MP0004084_abnormal_cardiac_muscle0.54353825

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.40228489
2Myokymia (HP:0002411)6.33944695
3Focal seizures (HP:0007359)5.27468086
4Febrile seizures (HP:0002373)4.91511497
5Epileptic encephalopathy (HP:0200134)4.29608347
6Atonic seizures (HP:0010819)4.15219448
7Action tremor (HP:0002345)3.87075584
8Progressive cerebellar ataxia (HP:0002073)3.81739331
9Generalized tonic-clonic seizures (HP:0002069)3.78541984
10Abnormality of binocular vision (HP:0011514)3.71054367
11Diplopia (HP:0000651)3.71054367
12Limb dystonia (HP:0002451)3.70117563
13Hemiparesis (HP:0001269)3.34967454
14Abnormal eating behavior (HP:0100738)3.31737225
15Dialeptic seizures (HP:0011146)3.26658028
16Absence seizures (HP:0002121)3.20796302
17Hemiplegia (HP:0002301)3.20726016
18Hyperventilation (HP:0002883)3.18800322
19Type II lissencephaly (HP:0007260)3.11920505
20Broad-based gait (HP:0002136)2.86270676
21Visual hallucinations (HP:0002367)2.81760632
22Ankle clonus (HP:0011448)2.81246546
23Megalencephaly (HP:0001355)2.69064646
24Gaze-evoked nystagmus (HP:0000640)2.68328084
25Spastic gait (HP:0002064)2.62466700
26Urinary bladder sphincter dysfunction (HP:0002839)2.59515996
27Status epilepticus (HP:0002133)2.58443154
28Polyphagia (HP:0002591)2.55826765
29Anxiety (HP:0000739)2.53423205
30Torticollis (HP:0000473)2.47692890
31Absent speech (HP:0001344)2.46995299
32Epileptiform EEG discharges (HP:0011182)2.46462998
33Mutism (HP:0002300)2.45655765
34Bundle branch block (HP:0011710)2.42789846
35Dysdiadochokinesis (HP:0002075)2.40898262
36Poor eye contact (HP:0000817)2.39979894
37Congenital stationary night blindness (HP:0007642)2.39939829
38Intention tremor (HP:0002080)2.31487319
39Polydipsia (HP:0001959)2.29897954
40Abnormal drinking behavior (HP:0030082)2.29897954
41Drooling (HP:0002307)2.27503720
42Increased circulating renin level (HP:0000848)2.26861059
43Postural instability (HP:0002172)2.26011056
44Abnormality of midbrain morphology (HP:0002418)2.25750086
45Molar tooth sign on MRI (HP:0002419)2.25750086
46EEG with generalized epileptiform discharges (HP:0011198)2.25345026
47Genetic anticipation (HP:0003743)2.24900918
48Inability to walk (HP:0002540)2.24213664
49Sleep apnea (HP:0010535)2.22737774
50Prolonged QT interval (HP:0001657)2.19615200
51Gait imbalance (HP:0002141)2.18931366
52Cerebral hypomyelination (HP:0006808)2.15700261
53Hypsarrhythmia (HP:0002521)2.15580029
54Supranuclear gaze palsy (HP:0000605)2.13164322
55Syncope (HP:0001279)2.12994592
56Amblyopia (HP:0000646)2.12961471
57Focal dystonia (HP:0004373)2.12291397
58Morphological abnormality of the pyramidal tract (HP:0002062)2.12037863
59Nephronophthisis (HP:0000090)2.11343556
60Truncal ataxia (HP:0002078)2.10706058
61Abnormality of the corticospinal tract (HP:0002492)2.10255616
62Pancreatic cysts (HP:0001737)2.09330082
63True hermaphroditism (HP:0010459)2.08628362
64Akinesia (HP:0002304)2.03837761
65Pancreatic fibrosis (HP:0100732)2.02057430
66Excessive salivation (HP:0003781)2.01759981
67Lissencephaly (HP:0001339)2.00753692
68Dysmetria (HP:0001310)1.99440942
69Ventricular fibrillation (HP:0001663)1.95886119
70Impaired vibration sensation in the lower limbs (HP:0002166)1.95879618
71Annular pancreas (HP:0001734)1.95670369
72Spastic tetraparesis (HP:0001285)1.92939736
73Abnormal EKG (HP:0003115)1.91859321
74Cerebellar dysplasia (HP:0007033)1.90068774
75Papilledema (HP:0001085)1.89943065
76Impaired social interactions (HP:0000735)1.87789042
77Abnormal social behavior (HP:0012433)1.87789042
78Metabolic alkalosis (HP:0200114)1.87763462
79Optic nerve hypoplasia (HP:0000609)1.87207868
80CNS hypomyelination (HP:0003429)1.87167352
81Craniofacial dystonia (HP:0012179)1.86251304
82Medial flaring of the eyebrow (HP:0010747)1.86074813
83Delusions (HP:0000746)1.85631522
84Heart block (HP:0012722)1.85344794
85Hypomagnesemia (HP:0002917)1.83985169
86Protruding tongue (HP:0010808)1.82874745
87Retinal dysplasia (HP:0007973)1.82141459
88Primary atrial arrhythmia (HP:0001692)1.81527833
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79611451
90Pachygyria (HP:0001302)1.78879825
91Tetraplegia (HP:0002445)1.78095396
92Progressive microcephaly (HP:0000253)1.78080775
93Neurofibrillary tangles (HP:0002185)1.78068550
94Atrial fibrillation (HP:0005110)1.75598970
95Decreased central vision (HP:0007663)1.75561714
96Progressive inability to walk (HP:0002505)1.73075496
97Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71483885
98Degeneration of the lateral corticospinal tracts (HP:0002314)1.71483885
99Supraventricular tachycardia (HP:0004755)1.71462863
100Bradykinesia (HP:0002067)1.71350120

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.25943160
2EPHA44.24630321
3NTRK33.79452433
4DAPK23.31699229
5CASK3.14056926
6PAK62.90157441
7NTRK22.71833679
8PINK12.51301781
9FRK2.37797738
10MAPK132.19365864
11PRKD31.90577208
12MINK11.86619727
13UHMK11.84902073
14PHKG21.83999505
15PHKG11.83999505
16CAMKK11.77369519
17MAP3K91.71974441
18PLK21.71877846
19NTRK11.61552835
20PRKCG1.61085217
21ADRBK21.55577833
22SIK21.55112471
23MAP3K41.46761779
24CAMK11.44877286
25PAK31.43646935
26GRK51.40745650
27BMPR1B1.37613078
28WNK41.24866798
29MAP4K21.24137215
30WNK31.22173986
31CDK51.19918042
32CAMK2A1.18024614
33PKN11.15567240
34TYRO31.14957753
35CAMKK21.11034330
36OXSR11.11032598
37CAMK2B1.09491550
38STK111.07290523
39PRKCH1.03565407
40TNIK1.00522580
41FGFR20.96048862
42GRK10.95176642
43SGK4940.94952191
44SGK2230.94952191
45MAP2K70.93827724
46DYRK20.93822715
47PNCK0.90746853
48DAPK10.84804121
49PRKCE0.81269427
50CSNK1G20.79305097
51CAMK2D0.77890777
52DYRK1A0.74692330
53MAPKAPK50.74294763
54CAMK2G0.74148696
55SGK20.72360105
56STK380.71173198
57STK390.69358588
58CAMK40.67976618
59MAPK120.65202515
60ADRBK10.64593004
61INSRR0.61709825
62CDK190.61195094
63MUSK0.60804124
64PRKCZ0.60542692
65SGK10.60093502
66LIMK10.59142894
67PIK3CA0.58839643
68MAPK150.58471941
69NUAK10.57543954
70TLK10.56772041
71TXK0.56543746
72TNK20.56016043
73MAP2K60.55745085
74CDK150.48821133
75ROCK10.48649272
76PRKACA0.48379703
77RPS6KA30.47611542
78CDK180.47327939
79NEK60.46649618
80MAP2K40.46479284
81PRKCA0.46343784
82ERBB20.44336413
83MARK20.44103615
84TIE10.43079066
85FES0.42387842
86CDK140.41453606
87PRKG10.41148164
88CDK11A0.40857889
89CSNK1G30.39734929
90CSNK1D0.38021828
91ZAK0.37510458
92ARAF0.36963910
93PRKAA10.36914882
94MKNK20.36914389
95MAP2K10.36342097
96TAOK30.36220521
97CSNK1A10.35793890
98MAPK100.34038194
99MAPKAPK30.33452425
100DAPK30.33216097

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.35064546
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05138942
3Morphine addiction_Homo sapiens_hsa050322.89820310
4Circadian entrainment_Homo sapiens_hsa047132.86687472
5GABAergic synapse_Homo sapiens_hsa047272.85113723
6Insulin secretion_Homo sapiens_hsa049112.74201105
7Glutamatergic synapse_Homo sapiens_hsa047242.72856680
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51725003
9Amphetamine addiction_Homo sapiens_hsa050312.50187048
10Dopaminergic synapse_Homo sapiens_hsa047282.04248891
11Phototransduction_Homo sapiens_hsa047442.02692884
12Gastric acid secretion_Homo sapiens_hsa049712.02549308
13Cocaine addiction_Homo sapiens_hsa050302.00006669
14Cardiac muscle contraction_Homo sapiens_hsa042601.94394398
15Salivary secretion_Homo sapiens_hsa049701.88285292
16Long-term potentiation_Homo sapiens_hsa047201.84045315
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81775379
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79043350
19Cholinergic synapse_Homo sapiens_hsa047251.75498926
20Olfactory transduction_Homo sapiens_hsa047401.74924858
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71624025
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67651911
23Taste transduction_Homo sapiens_hsa047421.67126983
24Calcium signaling pathway_Homo sapiens_hsa040201.61173656
25Oxytocin signaling pathway_Homo sapiens_hsa049211.57438805
26cAMP signaling pathway_Homo sapiens_hsa040241.54830260
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52375935
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44711776
29Serotonergic synapse_Homo sapiens_hsa047261.38525891
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38037160
31Renin secretion_Homo sapiens_hsa049241.34763659
32Long-term depression_Homo sapiens_hsa047301.26689136
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22221488
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20800155
35Nitrogen metabolism_Homo sapiens_hsa009101.20143205
36Collecting duct acid secretion_Homo sapiens_hsa049661.19717263
37Butanoate metabolism_Homo sapiens_hsa006501.12058555
38Oxidative phosphorylation_Homo sapiens_hsa001901.08025727
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07023281
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06810146
41Vascular smooth muscle contraction_Homo sapiens_hsa042700.99354746
42Linoleic acid metabolism_Homo sapiens_hsa005910.97518354
43Vitamin B6 metabolism_Homo sapiens_hsa007500.96206494
44Pancreatic secretion_Homo sapiens_hsa049720.95860819
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95581251
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88580163
47Alzheimers disease_Homo sapiens_hsa050100.87248991
48Bile secretion_Homo sapiens_hsa049760.86667794
49Dilated cardiomyopathy_Homo sapiens_hsa054140.86174194
50Ether lipid metabolism_Homo sapiens_hsa005650.86125202
51Parkinsons disease_Homo sapiens_hsa050120.85339015
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84448873
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82710699
54Thyroid hormone synthesis_Homo sapiens_hsa049180.80966563
55Axon guidance_Homo sapiens_hsa043600.77545273
56Melanogenesis_Homo sapiens_hsa049160.77035005
57Estrogen signaling pathway_Homo sapiens_hsa049150.75924610
58Ovarian steroidogenesis_Homo sapiens_hsa049130.71254620
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71231039
60GnRH signaling pathway_Homo sapiens_hsa049120.70595953
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68519731
62Dorso-ventral axis formation_Homo sapiens_hsa043200.65743010
63beta-Alanine metabolism_Homo sapiens_hsa004100.64301890
64Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62210666
65Gap junction_Homo sapiens_hsa045400.58453993
66MAPK signaling pathway_Homo sapiens_hsa040100.56868884
67Histidine metabolism_Homo sapiens_hsa003400.55221390
68Circadian rhythm_Homo sapiens_hsa047100.54567593
69Type II diabetes mellitus_Homo sapiens_hsa049300.53789202
70Ras signaling pathway_Homo sapiens_hsa040140.53370872
71Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.51900912
72Arginine and proline metabolism_Homo sapiens_hsa003300.51748191
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51642301
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51218787
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51014006
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50498698
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.50072322
78Regulation of autophagy_Homo sapiens_hsa041400.49789223
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48743392
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.47855292
81Oocyte meiosis_Homo sapiens_hsa041140.46642823
82ABC transporters_Homo sapiens_hsa020100.45314263
83Tryptophan metabolism_Homo sapiens_hsa003800.44479599
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43556378
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40842095
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40683554
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39234600
88Glucagon signaling pathway_Homo sapiens_hsa049220.38016079
89Fatty acid biosynthesis_Homo sapiens_hsa000610.37607904
90Glioma_Homo sapiens_hsa052140.37348804
91Mineral absorption_Homo sapiens_hsa049780.36710759
92Huntingtons disease_Homo sapiens_hsa050160.36701397
93Propanoate metabolism_Homo sapiens_hsa006400.36417581
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34010331
95Alcoholism_Homo sapiens_hsa050340.34010295
96Rap1 signaling pathway_Homo sapiens_hsa040150.33263958
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.32362473
98Glycerolipid metabolism_Homo sapiens_hsa005610.29689080
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29588105
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.29432751

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