C15ORF62

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.86162463
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.70403392
3negative regulation of phagocytosis (GO:0050765)5.66677338
4antigen processing and presentation of endogenous antigen (GO:0019883)5.22080734
5regulation of B cell receptor signaling pathway (GO:0050855)5.21055027
6antigen processing and presentation via MHC class Ib (GO:0002475)4.92343359
7regulation of mast cell degranulation (GO:0043304)4.66284262
8positive regulation of gamma-delta T cell activation (GO:0046645)4.48757120
9regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.46086598
10regulation of mast cell activation involved in immune response (GO:0033006)4.27542643
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.23619726
12negative regulation of cell killing (GO:0031342)4.23619726
13regulation of activation of Janus kinase activity (GO:0010533)4.10203105
14regulation of leukocyte degranulation (GO:0043300)4.08722942
15negative regulation of erythrocyte differentiation (GO:0045647)3.92662177
16regulation of myeloid leukocyte mediated immunity (GO:0002886)3.86612964
17B cell receptor signaling pathway (GO:0050853)3.64552612
18germinal center formation (GO:0002467)3.60188783
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.59900432
20negative regulation of mast cell activation (GO:0033004)3.58371206
21detection of bacterium (GO:0016045)3.56553658
22regulation of gamma-delta T cell activation (GO:0046643)3.49395902
23detection of other organism (GO:0098543)3.43293800
24keratinization (GO:0031424)3.42539145
25establishment of skin barrier (GO:0061436)3.38970464
26negative regulation of alpha-beta T cell activation (GO:0046636)3.34471051
27negative regulation of leukocyte mediated immunity (GO:0002704)3.31939153
28desmosome organization (GO:0002934)3.31807292
29regulation of water loss via skin (GO:0033561)3.30925469
30regulation of mast cell activation (GO:0033003)3.28940161
31positive thymic T cell selection (GO:0045059)3.26406535
32negative regulation of B cell proliferation (GO:0030889)3.24213500
33regulation of regulated secretory pathway (GO:1903305)3.19602423
34thymic T cell selection (GO:0045061)3.17275849
35response to laminar fluid shear stress (GO:0034616)3.14964459
36regulation of gamma-delta T cell differentiation (GO:0045586)3.14038114
37response to muramyl dipeptide (GO:0032495)3.06929903
38negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.03489554
39negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.00171951
40mannose metabolic process (GO:0006013)2.96172841
41positive regulation by organism of defense response of other organism involved in symbiotic interact2.95549400
42modulation by symbiont of host immune response (GO:0052553)2.95549400
43positive regulation by symbiont of host defense response (GO:0052509)2.95549400
44modulation by symbiont of host defense response (GO:0052031)2.95549400
45modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.95549400
46modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.95549400
47tolerance induction (GO:0002507)2.92417174
48positive regulation of Rap GTPase activity (GO:0032854)2.91094265
49modulation by symbiont of host cellular process (GO:0044068)2.86153480
50macrophage activation involved in immune response (GO:0002281)2.86101701
51detection of external biotic stimulus (GO:0098581)2.79494280
52positive regulation of keratinocyte differentiation (GO:0045618)2.78014212
53histone H3 deacetylation (GO:0070932)2.77887060
54negative thymic T cell selection (GO:0045060)2.77462278
55negative regulation of myotube differentiation (GO:0010832)2.76942920
56T cell selection (GO:0045058)2.74776450
57response to peptidoglycan (GO:0032494)2.74192470
58B cell homeostasis (GO:0001782)2.69854607
59positive regulation of antigen processing and presentation (GO:0002579)2.68578148
60positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.68498214
61leukocyte aggregation (GO:0070486)2.68367917
62neutrophil activation involved in immune response (GO:0002283)2.68056641
63regulation of antigen processing and presentation (GO:0002577)2.67255978
64Rap protein signal transduction (GO:0032486)2.65357474
65activation of Rac GTPase activity (GO:0032863)2.65204231
66negative regulation of T cell mediated immunity (GO:0002710)2.64560530
67histone H4 deacetylation (GO:0070933)2.64511122
68histone H3-K36 demethylation (GO:0070544)2.59833474
69negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.58366119
70positive regulation of cellular amide metabolic process (GO:0034250)2.57522740
71negative regulation of toll-like receptor signaling pathway (GO:0034122)2.56116702
72negative T cell selection (GO:0043383)2.55234043
73positive regulation of CREB transcription factor activity (GO:0032793)2.55110597
74positive T cell selection (GO:0043368)2.52975233
75regulation of natural killer cell differentiation (GO:0032823)2.50894027
76positive regulation of mast cell activation (GO:0033005)2.50234195
77negative regulation of lymphocyte mediated immunity (GO:0002707)2.50147484
78regulation of histone H3-K27 methylation (GO:0061085)2.49561080
79CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.49185384
80positive regulation of natural killer cell differentiation (GO:0032825)2.47982375
81positive regulation of leukocyte degranulation (GO:0043302)2.46829666
82positive regulation of mast cell degranulation (GO:0043306)2.44734534
83positive regulation of mast cell activation involved in immune response (GO:0033008)2.44734534
84granulocyte activation (GO:0036230)2.43181274
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.41860511
86negative regulation of viral release from host cell (GO:1902187)2.41706556
87modulation by virus of host process (GO:0019054)2.41124906
88activation of JUN kinase activity (GO:0007257)2.40803266
89myeloid cell activation involved in immune response (GO:0002275)2.40102506
90immunoglobulin mediated immune response (GO:0016064)2.40003412
91regulation of cellular amide metabolic process (GO:0034248)2.38484510
92negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.38298929
93detection of biotic stimulus (GO:0009595)2.36210816
94positive regulation of B cell differentiation (GO:0045579)2.34366481
95T cell homeostasis (GO:0043029)2.34136782
96peptide cross-linking (GO:0018149)2.33185924
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.32929156
98regulation of T cell receptor signaling pathway (GO:0050856)2.32584259
99regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31989868
100positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.31486874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYC_22102868_ChIP-Seq_BL_Human3.68120304
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.23862841
3VDR_21846776_ChIP-Seq_THP-1_Human3.21683818
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.86197595
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78118214
6* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.60556979
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.53499130
8GATA1_22025678_ChIP-Seq_K562_Human2.49618633
9TCF7_22412390_ChIP-Seq_EML_Mouse2.48330106
10LXR_22292898_ChIP-Seq_THP-1_Human2.35819127
11KDM2B_26808549_Chip-Seq_DND41_Human2.25258401
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.24157977
13MAF_26560356_Chip-Seq_TH1_Human2.20205717
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.10825755
15* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.10154002
16VDR_24763502_ChIP-Seq_THP-1_Human2.09358491
17KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.08049877
18RACK7_27058665_Chip-Seq_MCF-7_Human2.05790673
19TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04413455
20UTX_26944678_Chip-Seq_JUKART_Human1.96120947
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95415630
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95285382
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95189060
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93990781
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.91598021
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.91460332
27MAF_26560356_Chip-Seq_TH2_Human1.91347919
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.76068382
29STAT6_21828071_ChIP-Seq_BEAS2B_Human1.72086645
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69075609
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.65537633
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63437149
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62845404
34P68_20966046_ChIP-Seq_HELA_Human1.61814995
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.59093822
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.53111692
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52821729
38MYB_26560356_Chip-Seq_TH1_Human1.52690328
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52649996
40KDM2B_26808549_Chip-Seq_K562_Human1.52305154
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51959456
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.50618802
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.50346430
44SMC4_20622854_ChIP-Seq_HELA_Human1.49606050
45BCOR_27268052_Chip-Seq_Bcells_Human1.47928910
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.46106168
47RUNX_20019798_ChIP-Seq_JUKART_Human1.45625209
48RUNX1_27514584_Chip-Seq_MCF-7_Human1.45355224
49* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44372778
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42989935
51FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40815888
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39505946
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.34882729
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33300457
55SPI1_23127762_ChIP-Seq_K562_Human1.32437393
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31097744
57RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31070164
58MYB_26560356_Chip-Seq_TH2_Human1.30411384
59BCL6_27268052_Chip-Seq_Bcells_Human1.29482226
60SCL_19346495_ChIP-Seq_HPC-7_Human1.29163274
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27831820
62IRF8_27001747_Chip-Seq_BMDM_Mouse1.27302557
63CREB1_26743006_Chip-Seq_LNCaP_Human1.26691147
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26300613
65PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25212697
66* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.21432900
67ATF3_27146783_Chip-Seq_COLON_Human1.20785072
68GATA1_19941826_ChIP-Seq_K562_Human1.20169665
69PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19918375
70NCOR1_26117541_ChIP-Seq_K562_Human1.17884339
71PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17023444
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.16778206
73PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15706601
74SPI1_23547873_ChIP-Seq_NB4_Human1.14344870
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14211314
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13708421
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12776164
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12727094
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.12699859
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12188575
81SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12188575
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.10365790
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09672155
84GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08770016
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.08579339
86SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07036866
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06920752
88TP53_22127205_ChIP-Seq_IMR90_Human1.06080362
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05682620
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03591901
91ERG_21242973_ChIP-ChIP_JURKAT_Human1.03062719
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00776745
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.00654800
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.99754823
95CIITA_25753668_ChIP-Seq_RAJI_Human0.99664310
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99593563
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99385731
98E2F1_20622854_ChIP-Seq_HELA_Human0.99070747
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98646434
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98144641

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to2.98900462
2MP0002796_impaired_skin_barrier2.98747473
3MP0003763_abnormal_thymus_physiology2.97094336
4MP0010234_abnormal_vibrissa_follicle2.88186661
5MP0003705_abnormal_hypodermis_morpholog2.63374926
6MP0003303_peritoneal_inflammation2.58303624
7MP0001348_abnormal_lacrimal_gland2.41502678
8MP0001835_abnormal_antigen_presentation2.38115832
9MP0009840_abnormal_foam_cell2.34024128
10MP0004947_skin_inflammation2.23671013
11MP0004381_abnormal_hair_follicle2.23579937
12MP0001800_abnormal_humoral_immune2.16541992
13MP0000685_abnormal_immune_system2.15463487
14MP0002166_altered_tumor_susceptibility2.13083337
15MP0003300_gastrointestinal_ulcer2.11655667
16MP0005076_abnormal_cell_differentiation2.10111210
17MP0005000_abnormal_immune_tolerance2.05784133
18MP0003453_abnormal_keratinocyte_physiol2.02596066
19MP0001849_ear_inflammation1.95726028
20MP0004185_abnormal_adipocyte_glucose1.90212632
21MP0003191_abnormal_cellular_cholesterol1.88327113
22MP0005501_abnormal_skin_physiology1.86586354
23MP0002452_abnormal_antigen_presenting1.83207325
24MP0003646_muscle_fatigue1.82883843
25MP0001790_abnormal_immune_system1.82822139
26MP0005387_immune_system_phenotype1.82822139
27MP0002419_abnormal_innate_immunity1.79098488
28MP0005025_abnormal_response_to1.76762059
29MP0002723_abnormal_immune_serum1.75334331
30MP0009333_abnormal_splenocyte_physiolog1.75144719
31MP0002420_abnormal_adaptive_immunity1.74922841
32MP0001819_abnormal_immune_cell1.71236312
33MP0005451_abnormal_body_composition1.60770733
34MP0003566_abnormal_cell_adhesion1.60292594
35MP0002398_abnormal_bone_marrow1.58124513
36MP0002009_preneoplasia1.55787635
37MP0005671_abnormal_response_to1.54241912
38MP0003091_abnormal_cell_migration1.52682813
39MP0008057_abnormal_DNA_replication1.52645065
40MP0003183_abnormal_peptide_metabolism1.43996629
41MP0003172_abnormal_lysosome_physiology1.42330682
42MP0010155_abnormal_intestine_physiology1.42212668
43MP0002006_tumorigenesis1.41047767
44MP0000858_altered_metastatic_potential1.40682087
45MP0010307_abnormal_tumor_latency1.38717516
46MP0001216_abnormal_epidermal_layer1.38268161
47MP0009785_altered_susceptibility_to1.37961118
48MP0001873_stomach_inflammation1.36289950
49MP0000716_abnormal_immune_system1.36096822
50MP0005409_darkened_coat_color1.30194956
51MP0003828_pulmonary_edema1.29848442
52MP0005310_abnormal_salivary_gland1.29549729
53MP0001851_eye_inflammation1.27697086
54MP0002405_respiratory_system_inflammati1.27359938
55MP0004264_abnormal_extraembryonic_tissu1.26360987
56MP0002429_abnormal_blood_cell1.23147164
57MP0000015_abnormal_ear_pigmentation1.22047113
58MP0000703_abnormal_thymus_morphology1.17715829
59MP0009931_abnormal_skin_appearance1.16928269
60MP0005666_abnormal_adipose_tissue1.15917651
61MP0001853_heart_inflammation1.14891617
62MP0003724_increased_susceptibility_to1.14597827
63MP0002722_abnormal_immune_system1.14242761
64MP0005275_abnormal_skin_tensile1.11813743
65MP0000579_abnormal_nail_morphology1.09497758
66MP0001533_abnormal_skeleton_physiology1.08231029
67MP0002132_abnormal_respiratory_system1.08024598
68MP0000689_abnormal_spleen_morphology1.07849972
69MP0004808_abnormal_hematopoietic_stem1.07617124
70MP0002396_abnormal_hematopoietic_system1.06745921
71MP0005058_abnormal_lysosome_morphology1.06269279
72MP0005464_abnormal_platelet_physiology1.05577182
73MP0009278_abnormal_bone_marrow1.04842081
74MP0002998_abnormal_bone_remodeling1.04270830
75MP0002148_abnormal_hypersensitivity_rea1.03884929
76MP0001845_abnormal_inflammatory_respons1.02065119
77MP0000678_abnormal_parathyroid_gland1.01614209
78MP0002254_reproductive_system_inflammat0.99640850
79MP0005023_abnormal_wound_healing0.99590372
80MP0000490_abnormal_crypts_of0.98406197
81MP0004130_abnormal_muscle_cell0.90442747
82MP0003943_abnormal_hepatobiliary_system0.89824163
83MP0002933_joint_inflammation0.87481704
84MP0002060_abnormal_skin_morphology0.87065666
85MP0000377_abnormal_hair_follicle0.85844781
86MP0010352_gastrointestinal_tract_polyps0.85762544
87MP0003448_altered_tumor_morphology0.83860729
88MP0003656_abnormal_erythrocyte_physiolo0.83851697
89MP0002019_abnormal_tumor_incidence0.82739427
90MP0005375_adipose_tissue_phenotype0.82149930
91MP0003221_abnormal_cardiomyocyte_apopto0.80152741
92MP0008260_abnormal_autophagy0.80032432
93MP0003045_fibrosis0.79787312
94MP0002098_abnormal_vibrissa_morphology0.77513186
95MP0000367_abnormal_coat/_hair0.76980349
96MP0003866_abnormal_defecation0.75669490
97MP0008961_abnormal_basal_metabolism0.74781096
98MP0008469_abnormal_protein_level0.74400891
99MP0000467_abnormal_esophagus_morphology0.74308616
100MP0005397_hematopoietic_system_phenotyp0.73917998

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)4.60090512
2Eczematoid dermatitis (HP:0000976)4.19338673
3Birth length less than 3rd percentile (HP:0003561)3.53751143
4Abnormality of the fingertips (HP:0001211)3.47200873
5Hyperacusis (HP:0010780)3.44945411
6Breast hypoplasia (HP:0003187)3.38729067
7Broad face (HP:0000283)3.16958670
8Abnormality of nail color (HP:0100643)3.06866613
9Pustule (HP:0200039)3.00046332
10Thin bony cortex (HP:0002753)2.99094968
11Malnutrition (HP:0004395)2.91317633
12Lip pit (HP:0100267)2.90531343
13Recurrent bacterial skin infections (HP:0005406)2.76485546
14Testicular atrophy (HP:0000029)2.72940421
15Hemorrhage of the eye (HP:0011885)2.65704445
16Cellulitis (HP:0100658)2.59567094
17Increased connective tissue (HP:0009025)2.53451566
18Gastrointestinal infarctions (HP:0005244)2.42556751
19Palmoplantar hyperkeratosis (HP:0000972)2.35642588
20Renovascular hypertension (HP:0100817)2.35622359
21Abnormality of macrophages (HP:0004311)2.34889091
22Recurrent abscess formation (HP:0002722)2.34027439
23Recurrent viral infections (HP:0004429)2.33901194
24Mediastinal lymphadenopathy (HP:0100721)2.33157773
25Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30459697
26Gingivitis (HP:0000230)2.26786461
27Meningitis (HP:0001287)2.26071709
28Obstructive sleep apnea (HP:0002870)2.24524800
29Plantar hyperkeratosis (HP:0007556)2.21956776
30Progressive external ophthalmoplegia (HP:0000590)2.20998377
31Colitis (HP:0002583)2.19578073
32Ragged-red muscle fibers (HP:0003200)2.14676526
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.13837014
34Recurrent pneumonia (HP:0006532)2.12677040
35Alopecia of scalp (HP:0002293)2.11846315
36Elevated erythrocyte sedimentation rate (HP:0003565)2.10559627
37Gastrointestinal inflammation (HP:0004386)2.10148222
38Emphysema (HP:0002097)2.08955972
39Palmar hyperkeratosis (HP:0010765)2.07822770
40Dysmetric saccades (HP:0000641)2.06596409
41Thick nail (HP:0001805)2.05831461
42Slow saccadic eye movements (HP:0000514)2.05797328
43Inflammation of the large intestine (HP:0002037)2.02429698
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.02162090
45Gastrointestinal stroma tumor (HP:0100723)2.02066677
46Chronic mucocutaneous candidiasis (HP:0002728)2.01875426
47Recurrent cutaneous fungal infections (HP:0011370)2.01875426
48Papilloma (HP:0012740)2.01556569
49Verrucae (HP:0200043)2.01556569
50Recurrent skin infections (HP:0001581)2.00429629
51Recurrent fungal infections (HP:0002841)2.00105096
52Spontaneous hematomas (HP:0007420)1.99211593
53Obstructive lung disease (HP:0006536)1.95403374
54Chronic obstructive pulmonary disease (HP:0006510)1.95403374
55Milia (HP:0001056)1.95354719
56Microretrognathia (HP:0000308)1.94590453
57Myositis (HP:0100614)1.92091559
58Agammaglobulinemia (HP:0004432)1.92049291
59Spondylolisthesis (HP:0003302)1.91417912
60Erythema (HP:0010783)1.90762208
61Easy fatigability (HP:0003388)1.88534281
62Abnormality of liposaccharide metabolism (HP:0010968)1.86627011
63Abnormality of glycosphingolipid metabolism (HP:0004343)1.86627011
64Abnormality of glycolipid metabolism (HP:0010969)1.86627011
65Hypotrichosis (HP:0001006)1.85576452
66Depressed nasal tip (HP:0000437)1.85567794
67Axonal loss (HP:0003447)1.84927310
68Distal lower limb amyotrophy (HP:0008944)1.84302426
69Vasculitis (HP:0002633)1.83238466
70Disproportionate tall stature (HP:0001519)1.82986887
71Recurrent lower respiratory tract infections (HP:0002783)1.82443997
72Hypertriglyceridemia (HP:0002155)1.81947165
73Elfin facies (HP:0004428)1.79035998
74Insomnia (HP:0100785)1.78999168
75Nail dystrophy (HP:0008404)1.78547515
76Osteomyelitis (HP:0002754)1.77614809
77Orchitis (HP:0100796)1.76772621
78Cerebral inclusion bodies (HP:0100314)1.76378827
79Increased variability in muscle fiber diameter (HP:0003557)1.74775692
80Dyschromatopsia (HP:0007641)1.74513096
81Recurrent gram-negative bacterial infections (HP:0005420)1.73988061
82Skin ulcer (HP:0200042)1.70425154
83Urticaria (HP:0001025)1.69557508
84Flat acetabular roof (HP:0003180)1.69533216
85Ulnar bowing (HP:0003031)1.67694805
86Ankyloglossia (HP:0010296)1.65744839
87Retrobulbar optic neuritis (HP:0100654)1.65148183
88Optic neuritis (HP:0100653)1.65148183
89Joint hemorrhage (HP:0005261)1.64507342
90Deep venous thrombosis (HP:0002625)1.63959354
91Macroorchidism (HP:0000053)1.63167124
92Gangrene (HP:0100758)1.62248490
93Restrictive lung disease (HP:0002091)1.62087897
94Gastrointestinal dysmotility (HP:0002579)1.59840986
95Centrally nucleated skeletal muscle fibers (HP:0003687)1.59642782
96Nasal polyposis (HP:0100582)1.59376649
97Right ventricular cardiomyopathy (HP:0011663)1.59140935
98Ectropion (HP:0000656)1.58996798
99Abnormal blistering of the skin (HP:0008066)1.58922000
100Heterotopia (HP:0002282)1.58752404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.63874474
2MAP4K13.59111685
3PRPF4B3.34719595
4RIPK42.49813139
5CDC42BPA2.37411570
6ERN12.24783434
7EEF2K2.21831680
8CDK122.20100887
9BLK2.19808726
10IRAK42.13398788
11SIK12.09486492
12CAMKK12.01984533
13EPHA21.94447034
14SMG11.91415236
15MAP3K131.75228893
16ICK1.74042286
17CAMK1D1.70512380
18CDK81.59699578
19PKN21.54096787
20ZAP701.53570291
21MAP2K31.45498833
22BTK1.42704366
23MAP3K71.40682954
24MELK1.39844271
25MST1R1.37915039
26MAP3K101.34914512
27TNK21.33636796
28ACVR1B1.29747411
29SIK21.28208524
30MAP3K141.27848810
31FGFR41.26351673
32TYK21.24851845
33IRAK31.23860324
34MAP3K31.20594251
35PRKD21.19180513
36MAPK111.16176403
37MARK21.13814770
38PTK61.11320095
39CAMKK21.09353019
40JAK31.08344308
41LIMK11.06185574
42GRK61.04242677
43HCK1.04179762
44NEK91.03323538
45EPHB11.03094425
46CSK1.02055015
47BRSK10.98692937
48CDK40.96401930
49SIK30.96374384
50ITK0.94230011
51MAP3K60.89346168
52TGFBR10.87955167
53CAMK1G0.87391667
54MAP3K110.87139750
55FGR0.87015895
56JAK10.86649800
57MAPK120.86098967
58DAPK20.84417365
59RIPK10.83924397
60TBK10.82363951
61MAP3K10.81216977
62SYK0.79562275
63TTN0.79420472
64PDPK10.79121890
65MTOR0.77564506
66MAPK150.77046967
67KSR20.73895612
68IKBKB0.66247578
69TAOK10.63796263
70WNK10.61621828
71MAP2K60.61357705
72CLK10.60711713
73TRPM70.59831666
74MAP3K20.58450596
75FES0.58159415
76CSF1R0.56476750
77TAOK20.56147189
78IRAK20.55991381
79FGFR30.55957472
80CAMK40.55914399
81PDK10.54599452
82MAPK70.54303594
83LYN0.53646373
84MAPKAPK20.51826961
85RPS6KC10.51797987
86RPS6KL10.51797987
87BRSK20.49523980
88IKBKE0.48509364
89BMPR20.48109882
90LCK0.47766744
91RPS6KA60.44912810
92MST40.44040497
93PDGFRB0.43120858
94STK100.42941712
95LRRK20.41973812
96PDGFRA0.41582244
97RET0.41556851
98CHUK0.39807079
99STK380.38900694
100BMX0.38658075

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.64663770
2Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.01045846
3Leishmaniasis_Homo sapiens_hsa051401.95352746
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90628732
5Osteoclast differentiation_Homo sapiens_hsa043801.83606025
6Other glycan degradation_Homo sapiens_hsa005111.83335683
7Non-small cell lung cancer_Homo sapiens_hsa052231.81744263
8Acute myeloid leukemia_Homo sapiens_hsa052211.80391645
9VEGF signaling pathway_Homo sapiens_hsa043701.76089266
10T cell receptor signaling pathway_Homo sapiens_hsa046601.74959410
11Chronic myeloid leukemia_Homo sapiens_hsa052201.69709158
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.62473901
13Toxoplasmosis_Homo sapiens_hsa051451.61733540
14Allograft rejection_Homo sapiens_hsa053301.58500854
15Tuberculosis_Homo sapiens_hsa051521.51767941
16Graft-versus-host disease_Homo sapiens_hsa053321.51235679
17Autoimmune thyroid disease_Homo sapiens_hsa053201.48022216
18Pancreatic cancer_Homo sapiens_hsa052121.47541829
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47013674
20Influenza A_Homo sapiens_hsa051641.46917821
21Staphylococcus aureus infection_Homo sapiens_hsa051501.45975613
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.43450754
23Measles_Homo sapiens_hsa051621.41595860
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.38427100
25Bladder cancer_Homo sapiens_hsa052191.37373533
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36543448
27Renal cell carcinoma_Homo sapiens_hsa052111.35087526
28Inositol phosphate metabolism_Homo sapiens_hsa005621.34444818
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.33240781
30Notch signaling pathway_Homo sapiens_hsa043301.33212824
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32549783
32Primary immunodeficiency_Homo sapiens_hsa053401.30171131
33Neurotrophin signaling pathway_Homo sapiens_hsa047221.23186095
34Viral myocarditis_Homo sapiens_hsa054161.22752067
35mTOR signaling pathway_Homo sapiens_hsa041501.22286165
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.18775835
37Hepatitis B_Homo sapiens_hsa051611.18731428
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16530759
39TNF signaling pathway_Homo sapiens_hsa046681.15408772
40Herpes simplex infection_Homo sapiens_hsa051681.14341979
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08165831
42Asthma_Homo sapiens_hsa053101.07136167
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.06404566
44Hematopoietic cell lineage_Homo sapiens_hsa046401.06329714
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.05497505
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.04492527
47Antigen processing and presentation_Homo sapiens_hsa046121.04165332
48Apoptosis_Homo sapiens_hsa042101.03996172
49Endometrial cancer_Homo sapiens_hsa052131.02385269
50Platelet activation_Homo sapiens_hsa046111.02308378
51Colorectal cancer_Homo sapiens_hsa052100.99849365
52Choline metabolism in cancer_Homo sapiens_hsa052310.99502206
53Hepatitis C_Homo sapiens_hsa051600.99450344
54GnRH signaling pathway_Homo sapiens_hsa049120.92761443
55Insulin resistance_Homo sapiens_hsa049310.92685201
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.89209513
57Type I diabetes mellitus_Homo sapiens_hsa049400.88329456
58HTLV-I infection_Homo sapiens_hsa051660.86314891
59Fructose and mannose metabolism_Homo sapiens_hsa000510.86083062
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.85405187
61Chemokine signaling pathway_Homo sapiens_hsa040620.84176592
62Small cell lung cancer_Homo sapiens_hsa052220.82212703
63Prostate cancer_Homo sapiens_hsa052150.82180476
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80877570
65Viral carcinogenesis_Homo sapiens_hsa052030.80706671
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79421283
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78635773
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78506646
69Malaria_Homo sapiens_hsa051440.78490906
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.78290208
71MicroRNAs in cancer_Homo sapiens_hsa052060.77965625
72Prolactin signaling pathway_Homo sapiens_hsa049170.76498222
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.76413161
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76016316
75ErbB signaling pathway_Homo sapiens_hsa040120.75271402
76Insulin signaling pathway_Homo sapiens_hsa049100.75133668
77FoxO signaling pathway_Homo sapiens_hsa040680.74490298
78Legionellosis_Homo sapiens_hsa051340.73258345
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72887994
80Glioma_Homo sapiens_hsa052140.71558004
81HIF-1 signaling pathway_Homo sapiens_hsa040660.71108044
82Epstein-Barr virus infection_Homo sapiens_hsa051690.69648198
83Estrogen signaling pathway_Homo sapiens_hsa049150.67112202
84Amoebiasis_Homo sapiens_hsa051460.66840857
85Sphingolipid metabolism_Homo sapiens_hsa006000.66512479
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65088756
87Shigellosis_Homo sapiens_hsa051310.65051038
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64940689
89Endocytosis_Homo sapiens_hsa041440.63421713
90Lysosome_Homo sapiens_hsa041420.62888262
91MAPK signaling pathway_Homo sapiens_hsa040100.62079171
92Pertussis_Homo sapiens_hsa051330.60514179
93Proteoglycans in cancer_Homo sapiens_hsa052050.59269915
94Focal adhesion_Homo sapiens_hsa045100.57463069
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.54128832
96ABC transporters_Homo sapiens_hsa020100.53204455
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.53067551
98Lysine degradation_Homo sapiens_hsa003100.51312330
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50234754
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47168040

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