ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement (GO:0003351)	5.38333187
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.92871809
3	cilium movement (GO:0003341)	4.85848665
4	intraciliary transport (GO:0042073)	4.82621587
5	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.74501117
6	axonemal dynein complex assembly (GO:0070286)	4.67323822
7	interkinetic nuclear migration (GO:0022027)	4.38614599
8	ubiquinone metabolic process (GO:0006743)	4.33615684
9	nucleobase catabolic process (GO:0046113)	4.27422031
10	cellular ketone body metabolic process (GO:0046950)	4.27122359
11	parental behavior (GO:0060746)	4.14737506
12	regulation of retinoic acid receptor signaling pathway (GO:0048385)	4.13139555
13	maternal behavior (GO:0042711)	4.01430087
14	ubiquinone biosynthetic process (GO:0006744)	3.98847673
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.92009887
16	protein localization to cilium (GO:0061512)	3.84835642
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.83236264
18	ketone body metabolic process (GO:1902224)	3.76950356
19	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.74241997
20	water-soluble vitamin biosynthetic process (GO:0042364)	3.71226955
21	cilium morphogenesis (GO:0060271)	3.59249460
22	axoneme assembly (GO:0035082)	3.58381299
23	retinal ganglion cell axon guidance (GO:0031290)	3.54130242
24	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.54099238
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.39170274
26	negative regulation of transcription by competitive promoter binding (GO:0010944)	3.34775469
27	regulation of cilium movement (GO:0003352)	3.31721191
28	behavioral response to ethanol (GO:0048149)	3.22178013
29	cilium or flagellum-dependent cell motility (GO:0001539)	3.15204876
30	synaptic vesicle exocytosis (GO:0016079)	3.15119130
31	GPI anchor biosynthetic process (GO:0006506)	3.14790356
32	positive regulation of meiosis (GO:0045836)	3.11569078
33	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.11085315
34	quinone biosynthetic process (GO:1901663)	3.10813521
35	nonmotile primary cilium assembly (GO:0035058)	3.08097021
36	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.06239066
37	cilium organization (GO:0044782)	3.03906613
38	cilium assembly (GO:0042384)	3.01858730
39	protein polyglutamylation (GO:0018095)	2.98622066
40	behavioral response to nicotine (GO:0035095)	2.97907153
41	GPI anchor metabolic process (GO:0006505)	2.95022201
42	positive regulation of meiotic cell cycle (GO:0051446)	2.91884200
43	positive regulation of growth hormone secretion (GO:0060124)	2.85206893
44	respiratory electron transport chain (GO:0022904)	2.77593522
45	protein neddylation (GO:0045116)	2.76496267
46	electron transport chain (GO:0022900)	2.75912858
47	ATP synthesis coupled proton transport (GO:0015986)	2.74924324
48	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.74924324
49	forebrain morphogenesis (GO:0048853)	2.73266256
50	isoprenoid biosynthetic process (GO:0008299)	2.72734288
51	ribosomal large subunit biogenesis (GO:0042273)	2.71224245
52	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.70682499
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.70682499
54	NADH dehydrogenase complex assembly (GO:0010257)	2.70682499
55	substrate-dependent cell migration (GO:0006929)	2.68828975
56	organelle disassembly (GO:1903008)	2.68009319
57	dendritic spine morphogenesis (GO:0060997)	2.64732416
58	C-terminal protein lipidation (GO:0006501)	2.64326924
59	regulation of smooth muscle cell differentiation (GO:0051150)	2.62292447
60	aldehyde catabolic process (GO:0046185)	2.62095928
61	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59969033
62	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59969033
63	protein complex biogenesis (GO:0070271)	2.54458418
64	positive regulation of mitochondrial fission (GO:0090141)	2.53678411
65	positive regulation of protein autophosphorylation (GO:0031954)	2.52786151
66	short-term memory (GO:0007614)	2.52727513
67	C-terminal protein amino acid modification (GO:0018410)	2.52726980
68	ribosomal small subunit assembly (GO:0000028)	2.51727256
69	sperm motility (GO:0030317)	2.50633433
70	L-methionine salvage (GO:0071267)	2.49539601
71	L-methionine biosynthetic process (GO:0071265)	2.49539601
72	amino acid salvage (GO:0043102)	2.49539601
73	presynaptic membrane organization (GO:0097090)	2.47495816
74	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.47472515
75	motile cilium assembly (GO:0044458)	2.46509343
76	primitive streak formation (GO:0090009)	2.44621633
77	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.44294790
78	positive regulation of prostaglandin secretion (GO:0032308)	2.43942343
79	glycolipid biosynthetic process (GO:0009247)	2.43529124
80	microtubule bundle formation (GO:0001578)	2.41351924
81	cullin deneddylation (GO:0010388)	2.41080050
82	respiratory chain complex IV assembly (GO:0008535)	2.40608751
83	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	2.39851451
84	quinone metabolic process (GO:1901661)	2.39581342
85	left/right pattern formation (GO:0060972)	2.39275460
86	mitochondrial respiratory chain complex assembly (GO:0033108)	2.38758909
87	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.38532764
88	ventricular system development (GO:0021591)	2.38112316
89	protein deneddylation (GO:0000338)	2.36892961
90	brain morphogenesis (GO:0048854)	2.36819707
91	presynaptic membrane assembly (GO:0097105)	2.32937670
92	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.31856490
93	aggressive behavior (GO:0002118)	2.31278236
94	sequestering of actin monomers (GO:0042989)	2.29240913
95	cotranslational protein targeting to membrane (GO:0006613)	2.27088265
96	cellular component assembly involved in morphogenesis (GO:0010927)	2.26848552
97	viral transcription (GO:0019083)	2.26768740
98	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.26737371
99	cholesterol biosynthetic process (GO:0006695)	2.26129025
100	tyrosine phosphorylation of STAT protein (GO:0007260)	2.26093540

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.70544633
2	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.59061369
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.55329550
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.47330552
5	FUS_26573619_Chip-Seq_HEK293_Human	2.45247390
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.43542517
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.41639538
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.37117162
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.34194993
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.25319473
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.22626075
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.16194630
13	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.13009964
14	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12805651
15	VDR_22108803_ChIP-Seq_LS180_Human	2.12478845
16	EWS_26573619_Chip-Seq_HEK293_Human	2.06070301
17	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.99948893
18	TAF15_26573619_Chip-Seq_HEK293_Human	1.98657473
19	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.94499504
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.93537508
21	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.92121458
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.87695667
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.85229115
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.84505042
25	P300_19829295_ChIP-Seq_ESCs_Human	1.83489477
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.75995415
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73601836
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.71602530
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.65203942
30	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.62845946
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60721563
32	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.48989443
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.47946309
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45239296
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.45014447
36	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41585300
37	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37851161
38	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.35523946
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.34417066
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.33564984
41	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.32562585
42	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.31988886
43	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31345553
44	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.30975409
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.30932641
46	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.30107482
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29905064
48	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27473497
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.26972059
50	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.24715882
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.24075239
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.22880489
53	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.22846193
54	AR_25329375_ChIP-Seq_VCAP_Human	1.21272753
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19113740
56	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.18648607
57	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17979313
58	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.17944166
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17563967
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.16314480
61	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16082280
62	STAT3_23295773_ChIP-Seq_U87_Human	1.14863474
63	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13308216
64	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12323669
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.11720613
66	NCOR_22424771_ChIP-Seq_293T_Human	1.11322541
67	REST_21632747_ChIP-Seq_MESCs_Mouse	1.08168962
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.07842769
69	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.07667602
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.05723078
71	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.04780216
72	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.04344649
73	CBP_20019798_ChIP-Seq_JUKART_Human	1.04097403
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04097403
75	JUN_21703547_ChIP-Seq_K562_Human	1.03664307
76	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.02040510
77	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01742905
78	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.00946966
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.00313829
80	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.99394615
81	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.98500547
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.98143013
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97210528
84	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.96748873
85	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.96583124
86	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.95879116
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.94080881
88	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.93945216
89	TCF4_23295773_ChIP-Seq_U87_Human	0.93887137
90	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93798877
91	TBL1_22424771_ChIP-Seq_293T_Human	0.92956486
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.92630928
93	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.92367013
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.91432473
95	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.91348223
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.90280122
97	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.90255204
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90128314
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90110367
100	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89255253

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.90652702
2	MP0006292_abnormal_olfactory_placode	3.71074372
3	MP0001188_hyperpigmentation	3.31461958
4	MP0002163_abnormal_gland_morphology	3.24344627
5	MP0001529_abnormal_vocalization	2.97090271
6	MP0008789_abnormal_olfactory_epithelium	2.65610749
7	MP0003880_abnormal_central_pattern	2.49653033
8	MP0002938_white_spotting	2.47728180
9	MP0005084_abnormal_gallbladder_morpholo	2.46241827
10	MP0010368_abnormal_lymphatic_system	2.40285915
11	MP0005499_abnormal_olfactory_system	2.37970329
12	MP0005394_taste/olfaction_phenotype	2.37970329
13	MP0006072_abnormal_retinal_apoptosis	2.30304703
14	MP0005379_endocrine/exocrine_gland_phen	2.22781184
15	MP0001984_abnormal_olfaction	2.19440656
16	MP0002928_abnormal_bile_duct	2.07660549
17	MP0002822_catalepsy	2.00852561
18	MP0003136_yellow_coat_color	1.95343037
19	MP0005646_abnormal_pituitary_gland	1.90725118
20	MP0002909_abnormal_adrenal_gland	1.83845808
21	MP0005423_abnormal_somatic_nervous	1.83190849
22	MP0006276_abnormal_autonomic_nervous	1.74810729
23	MP0003122_maternal_imprinting	1.72998779
24	MP0005645_abnormal_hypothalamus_physiol	1.61681262
25	MP0005174_abnormal_tail_pigmentation	1.58609339
26	MP0000631_abnormal_neuroendocrine_gland	1.53493245
27	MP0004133_heterotaxia	1.53013798
28	MP0002160_abnormal_reproductive_system	1.51318154
29	MP0005253_abnormal_eye_physiology	1.46113460
30	MP0000778_abnormal_nervous_system	1.45949701
31	MP0002837_dystrophic_cardiac_calcinosis	1.44778183
32	MP0002272_abnormal_nervous_system	1.40919173
33	MP0004859_abnormal_synaptic_plasticity	1.36706925
34	MP0001879_abnormal_lymphatic_vessel	1.36605933
35	MP0002638_abnormal_pupillary_reflex	1.35014270
36	MP0000372_irregular_coat_pigmentation	1.33513159
37	MP0008058_abnormal_DNA_repair	1.30707508
38	MP0003890_abnormal_embryonic-extraembry	1.23007093
39	MP0003787_abnormal_imprinting	1.22590343
40	MP0005187_abnormal_penis_morphology	1.20147451
41	MP0002233_abnormal_nose_morphology	1.19013991
42	MP0005248_abnormal_Harderian_gland	1.15268794
43	MP0008875_abnormal_xenobiotic_pharmacok	1.14814001
44	MP0005551_abnormal_eye_electrophysiolog	1.14334273
45	MP0002557_abnormal_social/conspecific_i	1.14172630
46	MP0005367_renal/urinary_system_phenotyp	1.12221313
47	MP0000516_abnormal_urinary_system	1.12221313
48	MP0002734_abnormal_mechanical_nocicepti	1.11561683
49	MP0009046_muscle_twitch	1.11279611
50	MP0000049_abnormal_middle_ear	1.10823747
51	MP0003011_delayed_dark_adaptation	1.10716052
52	MP0003121_genomic_imprinting	1.03921440
53	MP0001293_anophthalmia	1.02010170
54	MP0005389_reproductive_system_phenotype	1.01781556
55	MP0002095_abnormal_skin_pigmentation	1.00724913
56	MP0008995_early_reproductive_senescence	0.99418170
57	MP0008877_abnormal_DNA_methylation	0.98507585
58	MP0001905_abnormal_dopamine_level	0.96801500
59	MP0004147_increased_porphyrin_level	0.94318971
60	MP0002572_abnormal_emotion/affect_behav	0.94241838
61	MP0002653_abnormal_ependyma_morphology	0.94190092
62	MP0005409_darkened_coat_color	0.92634699
63	MP0002184_abnormal_innervation	0.92245760
64	MP0005195_abnormal_posterior_eye	0.92142188
65	MP0001485_abnormal_pinna_reflex	0.90963453
66	MP0003693_abnormal_embryo_hatching	0.88971508
67	MP0002752_abnormal_somatic_nervous	0.83541772
68	MP0009745_abnormal_behavioral_response	0.82734678
69	MP0000015_abnormal_ear_pigmentation	0.82533703
70	MP0009250_abnormal_appendicular_skeleto	0.82138300
71	MP0000427_abnormal_hair_cycle	0.81911108
72	MP0003635_abnormal_synaptic_transmissio	0.81569988
73	MP0002735_abnormal_chemical_nociception	0.81558020
74	MP0003718_maternal_effect	0.80405024
75	MP0003385_abnormal_body_wall	0.79894759
76	MP0001764_abnormal_homeostasis	0.79676644
77	MP0004142_abnormal_muscle_tone	0.79549563
78	MP0010386_abnormal_urinary_bladder	0.79369421
79	MP0002102_abnormal_ear_morphology	0.77998954
80	MP0001970_abnormal_pain_threshold	0.77743368
81	MP0005391_vision/eye_phenotype	0.76595225
82	MP0002751_abnormal_autonomic_nervous	0.74631244
83	MP0001968_abnormal_touch/_nociception	0.74398936
84	MP0003942_abnormal_urinary_system	0.72110978
85	MP0001486_abnormal_startle_reflex	0.71677609
86	MP0002063_abnormal_learning/memory/cond	0.70885399
87	MP0004885_abnormal_endolymph	0.70281754
88	MP0002882_abnormal_neuron_morphology	0.70241583
89	MP0002234_abnormal_pharynx_morphology	0.68957651
90	MP0001286_abnormal_eye_development	0.68823818
91	MP0000647_abnormal_sebaceous_gland	0.68301168
92	MP0004134_abnormal_chest_morphology	0.67710712
93	MP0000026_abnormal_inner_ear	0.65413364
94	MP0001929_abnormal_gametogenesis	0.64725258
95	MP0004742_abnormal_vestibular_system	0.64664428
96	MP0003861_abnormal_nervous_system	0.64236474
97	MP0003698_abnormal_male_reproductive	0.64103866
98	MP0001542_abnormal_bone_strength	0.63764856
99	MP0004270_analgesia	0.63382654
100	MP0009764_decreased_sensitivity_to	0.62577444

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	4.38374493
2	Abnormal respiratory motile cilium physiology (HP:0012261)	4.32235220
3	Abnormal respiratory epithelium morphology (HP:0012253)	4.16069192
4	Abnormal respiratory motile cilium morphology (HP:0005938)	4.16069192
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.92157136
6	Rhinitis (HP:0012384)	3.70348838
7	True hermaphroditism (HP:0010459)	3.50209768
8	Medial flaring of the eyebrow (HP:0010747)	3.45976732
9	Pancreatic fibrosis (HP:0100732)	3.35658912
10	Acute necrotizing encephalopathy (HP:0006965)	3.32390603
11	Congenital primary aphakia (HP:0007707)	3.23666226
12	Gait imbalance (HP:0002141)	3.23238178
13	Absent/shortened dynein arms (HP:0200106)	3.21419346
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.21419346
15	Nephronophthisis (HP:0000090)	3.16454988
16	Abnormality of midbrain morphology (HP:0002418)	3.16042716
17	Molar tooth sign on MRI (HP:0002419)	3.16042716
18	Pancreatic cysts (HP:0001737)	3.13680699
19	Progressive macrocephaly (HP:0004481)	2.96803828
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.89977992
21	Short tibia (HP:0005736)	2.87014780
22	Acute encephalopathy (HP:0006846)	2.81139350
23	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.80026134
24	Adrenal hypoplasia (HP:0000835)	2.78217061
25	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.76418768
26	Nephrogenic diabetes insipidus (HP:0009806)	2.73832399
27	Mitochondrial inheritance (HP:0001427)	2.68122460
28	Genital tract atresia (HP:0001827)	2.61735717
29	Chronic bronchitis (HP:0004469)	2.60833123
30	Stenosis of the external auditory canal (HP:0000402)	2.60599354
31	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.57135665
32	Type II lissencephaly (HP:0007260)	2.55637493
33	Hyperglycinemia (HP:0002154)	2.52747625
34	Vaginal atresia (HP:0000148)	2.52094630
35	Concave nail (HP:0001598)	2.48937790
36	Occipital encephalocele (HP:0002085)	2.47142422
37	Abnormality of the renal medulla (HP:0100957)	2.41933859
38	Male pseudohermaphroditism (HP:0000037)	2.40249912
39	Atonic seizures (HP:0010819)	2.38830847
40	Sclerocornea (HP:0000647)	2.37250051
41	Increased CSF lactate (HP:0002490)	2.35284897
42	Ketoacidosis (HP:0001993)	2.32338956
43	Median cleft lip (HP:0000161)	2.32302241
44	Tubulointerstitial nephritis (HP:0001970)	2.31349984
45	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.30943158
46	Abnormal protein N-linked glycosylation (HP:0012347)	2.30943158
47	Abnormal protein glycosylation (HP:0012346)	2.30943158
48	Abnormal glycosylation (HP:0012345)	2.30943158
49	Postaxial foot polydactyly (HP:0001830)	2.29491811
50	Choroideremia (HP:0001139)	2.26935138
51	Tubular atrophy (HP:0000092)	2.26381810
52	Hyperinsulinemic hypoglycemia (HP:0000825)	2.26190000
53	Bronchiectasis (HP:0002110)	2.24395536
54	Abolished electroretinogram (ERG) (HP:0000550)	2.22718086
55	Cerebellar dysplasia (HP:0007033)	2.21346152
56	Facial hemangioma (HP:0000329)	2.21223078
57	Febrile seizures (HP:0002373)	2.18363029
58	Cystic liver disease (HP:0006706)	2.17442665
59	Hepatocellular necrosis (HP:0001404)	2.14762629
60	Aplasia/hypoplasia of the uterus (HP:0008684)	2.14563548
61	Optic disc pallor (HP:0000543)	2.13563092
62	Poor coordination (HP:0002370)	2.12755235
63	Cerebral edema (HP:0002181)	2.05376314
64	Myokymia (HP:0002411)	2.03396295
65	Lipid accumulation in hepatocytes (HP:0006561)	2.03295980
66	Hepatic necrosis (HP:0002605)	2.02653397
67	Heterochromia iridis (HP:0001100)	2.00663758
68	Increased hepatocellular lipid droplets (HP:0006565)	1.98650971
69	Exertional dyspnea (HP:0002875)	1.96622229
70	Postaxial hand polydactyly (HP:0001162)	1.95204898
71	Pachygyria (HP:0001302)	1.94560390
72	Stillbirth (HP:0003826)	1.93611803
73	Left ventricular hypertrophy (HP:0001712)	1.93233330
74	Neonatal respiratory distress (HP:0002643)	1.91818401
75	Hypoplasia of the uterus (HP:0000013)	1.88689766
76	Decreased testicular size (HP:0008734)	1.86141676
77	Hypoplastic pelvis (HP:0008839)	1.85071932
78	Anencephaly (HP:0002323)	1.82696840
79	Poor suck (HP:0002033)	1.79780037
80	Abnormality of cells of the erythroid lineage (HP:0012130)	1.79717291
81	Failure to thrive in infancy (HP:0001531)	1.79614617
82	Ketosis (HP:0001946)	1.77985032
83	Increased serum lactate (HP:0002151)	1.77664485
84	Narrow forehead (HP:0000341)	1.76735644
85	Renal hypoplasia (HP:0000089)	1.73394891
86	Specific learning disability (HP:0001328)	1.73052852
87	Pendular nystagmus (HP:0012043)	1.72807431
88	Fibular hypoplasia (HP:0003038)	1.71945275
89	Neoplasm of the adrenal cortex (HP:0100641)	1.71063299
90	Cortical visual impairment (HP:0100704)	1.71058625
91	Retinal dysplasia (HP:0007973)	1.70020997
92	Aplasia/Hypoplasia of the lens (HP:0008063)	1.68167194
93	Congenital hepatic fibrosis (HP:0002612)	1.68052088
94	Broad foot (HP:0001769)	1.67589661
95	3-Methylglutaconic aciduria (HP:0003535)	1.66466731
96	Abnormality of serine family amino acid metabolism (HP:0010894)	1.65262550
97	Abnormality of glycine metabolism (HP:0010895)	1.65262550
98	Palpebral edema (HP:0100540)	1.63505046
99	Glycosuria (HP:0003076)	1.62617140
100	Abnormality of urine glucose concentration (HP:0011016)	1.62617140

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	5.23373007
2	MAP4K2	2.94166978
3	STK38L	2.85822037
4	TRIM28	2.82929736
5	STK24	2.78179121
6	BCR	2.72783087
7	ZAK	2.69600753
8	STK16	2.58880045
9	MST4	2.44526656
10	CASK	2.27364514
11	FRK	2.13938896
12	BMPR1B	2.13282319
13	MAP3K12	1.81592581
14	MARK1	1.81398118
15	SRPK1	1.74670919
16	STK3	1.72200002
17	CSNK1G3	1.68519397
18	MAP3K13	1.67742715
19	CSNK1G2	1.65677616
20	ADRBK2	1.63629881
21	MAP3K4	1.57149241
22	GRK1	1.49535867
23	DYRK3	1.42643615
24	CSNK1G1	1.41044765
25	VRK2	1.39703512
26	NUAK1	1.37013688
27	INSRR	1.36112180
28	DYRK2	1.35170801
29	ERBB3	1.35021777
30	CSNK1A1L	1.34916646
31	WNK3	1.30841128
32	TNIK	1.25625714
33	PINK1	1.15728244
34	MAP2K7	1.14085863
35	EPHA4	1.13523692
36	BUB1	1.11603819
37	CCNB1	1.09935719
38	BCKDK	1.09101490
39	PLK3	1.07164904
40	LIMK1	1.05831332
41	WNK4	1.03319171
42	STK39	1.02401860
43	PIM2	1.01396386
44	TEC	1.00016186
45	NTRK3	0.96498196
46	MAPK15	0.96358746
47	PAK3	0.94955685
48	PLK1	0.93603524
49	TAF1	0.87106017
50	PRKCE	0.86995423
51	TTK	0.82343088
52	PRKCG	0.80486751
53	EPHB2	0.76319765
54	PLK2	0.74266032
55	OXSR1	0.72417542
56	EPHA3	0.71916339
57	FGFR2	0.68801510
58	BRSK2	0.67926031
59	ADRBK1	0.66819935
60	MKNK1	0.64435986
61	VRK1	0.63894420
62	GRK7	0.62361914
63	NTRK2	0.61092082
64	DYRK1B	0.58073145
65	AURKA	0.57202908
66	TGFBR1	0.57104285
67	CDK19	0.55673508
68	CDK8	0.55043212
69	CAMK2A	0.54747023
70	MAP3K5	0.54149394
71	MAPK13	0.53639322
72	NEK2	0.50311290
73	GRK5	0.49824863
74	PHKG2	0.47725890
75	PHKG1	0.47725890
76	MKNK2	0.45786713
77	CDK9	0.45551652
78	WEE1	0.45208122
79	CAMKK2	0.44924208
80	DYRK1A	0.44862661
81	NEK1	0.40459508
82	EIF2AK2	0.39740771
83	PRKACA	0.39317683
84	OBSCN	0.36251163
85	CSNK1E	0.36091766
86	CDK5	0.31681008
87	DAPK3	0.31538837
88	PBK	0.31016387
89	FER	0.30384786
90	AURKB	0.30014399
91	CSNK2A2	0.29635911
92	UHMK1	0.28704589
93	PNCK	0.28539578
94	CAMK2B	0.27546869
95	CSNK1A1	0.27363843
96	PRKACB	0.26882295
97	CSNK2A1	0.26365801
98	MYLK	0.26348604
99	MAP2K4	0.24247018
100	ILK	0.23734535

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.17378848
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.36776245
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.96355337
4	Parkinsons disease_Homo sapiens_hsa05012	2.71988829
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.65732011
6	Protein export_Homo sapiens_hsa03060	2.60365834
7	Butanoate metabolism_Homo sapiens_hsa00650	2.42159419
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.42060944
9	Ribosome_Homo sapiens_hsa03010	2.40197349
10	Huntingtons disease_Homo sapiens_hsa05016	2.17992460
11	Steroid biosynthesis_Homo sapiens_hsa00100	2.13331923
12	Basal transcription factors_Homo sapiens_hsa03022	2.03060636
13	Alzheimers disease_Homo sapiens_hsa05010	1.87941846
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.68591123
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.65716908
16	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.63066344
17	Collecting duct acid secretion_Homo sapiens_hsa04966	1.56211988
18	Propanoate metabolism_Homo sapiens_hsa00640	1.53890822
19	Nicotine addiction_Homo sapiens_hsa05033	1.51903104
20	Phototransduction_Homo sapiens_hsa04744	1.45014816
21	Cardiac muscle contraction_Homo sapiens_hsa04260	1.40861465
22	RNA polymerase_Homo sapiens_hsa03020	1.37357040
23	Folate biosynthesis_Homo sapiens_hsa00790	1.34592855
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.32170151
25	Homologous recombination_Homo sapiens_hsa03440	1.31107426
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21380449
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.18648936
28	Regulation of autophagy_Homo sapiens_hsa04140	1.18521438
29	beta-Alanine metabolism_Homo sapiens_hsa00410	1.14385754
30	Fatty acid metabolism_Homo sapiens_hsa01212	1.13547381
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.11124007
32	Proteasome_Homo sapiens_hsa03050	1.09544169
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.09469595
34	Peroxisome_Homo sapiens_hsa04146	1.08552520
35	Fatty acid elongation_Homo sapiens_hsa00062	1.06679728
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04786238
37	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.03814997
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.02226996
39	GABAergic synapse_Homo sapiens_hsa04727	0.99626845
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.98563539
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.97375579
42	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92660841
43	Morphine addiction_Homo sapiens_hsa05032	0.92507795
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.89343107
45	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88629741
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88146282
47	Insulin secretion_Homo sapiens_hsa04911	0.87588588
48	Linoleic acid metabolism_Homo sapiens_hsa00591	0.86254360
49	Glutathione metabolism_Homo sapiens_hsa00480	0.85240396
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84173977
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.83989213
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83566556
53	Pyruvate metabolism_Homo sapiens_hsa00620	0.81189091
54	Metabolic pathways_Homo sapiens_hsa01100	0.78296052
55	Fatty acid degradation_Homo sapiens_hsa00071	0.78237099
56	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.77263671
57	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.75787244
58	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75696824
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.75598559
60	Fat digestion and absorption_Homo sapiens_hsa04975	0.74362429
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73330647
62	RNA degradation_Homo sapiens_hsa03018	0.71149734
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.70593638
64	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66832890
65	Retinol metabolism_Homo sapiens_hsa00830	0.66360454
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.64238710
67	Vibrio cholerae infection_Homo sapiens_hsa05110	0.63585794
68	Taste transduction_Homo sapiens_hsa04742	0.62957562
69	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.62797175
70	Circadian entrainment_Homo sapiens_hsa04713	0.61942122
71	Dopaminergic synapse_Homo sapiens_hsa04728	0.60307995
72	Serotonergic synapse_Homo sapiens_hsa04726	0.59805606
73	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.57832148
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.57479942
75	Caffeine metabolism_Homo sapiens_hsa00232	0.57330064
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56503836
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.55917570
78	Ether lipid metabolism_Homo sapiens_hsa00565	0.55709029
79	Sulfur metabolism_Homo sapiens_hsa00920	0.55118148
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.54953587
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.54819614
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.53490189
83	Olfactory transduction_Homo sapiens_hsa04740	0.52798020
84	Oocyte meiosis_Homo sapiens_hsa04114	0.50001819
85	p53 signaling pathway_Homo sapiens_hsa04115	0.48376026
86	Purine metabolism_Homo sapiens_hsa00230	0.47433800
87	Cocaine addiction_Homo sapiens_hsa05030	0.47407272
88	Basal cell carcinoma_Homo sapiens_hsa05217	0.44737911
89	Hippo signaling pathway_Homo sapiens_hsa04390	0.43189974
90	Salivary secretion_Homo sapiens_hsa04970	0.42873097
91	Pancreatic secretion_Homo sapiens_hsa04972	0.40762214
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.40724719
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40446621
94	Non-homologous end-joining_Homo sapiens_hsa03450	0.40209415
95	Mineral absorption_Homo sapiens_hsa04978	0.39726847
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.39270739
97	Circadian rhythm_Homo sapiens_hsa04710	0.38203604
98	Cholinergic synapse_Homo sapiens_hsa04725	0.38091311
99	Axon guidance_Homo sapiens_hsa04360	0.37315363
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.37218129

C15ORF65

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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