ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle maturation (GO:0016188)	6.58122242
2	glutamate secretion (GO:0014047)	6.03965177
3	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.82795499
4	regulation of short-term neuronal synaptic plasticity (GO:0048172)	5.70437998
5	synaptic vesicle exocytosis (GO:0016079)	5.32651662
6	regulation of synaptic vesicle exocytosis (GO:2000300)	4.96744162
7	postsynaptic membrane organization (GO:0001941)	4.85606303
8	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.64140027
9	neurotransmitter secretion (GO:0007269)	4.63555422
10	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	4.62836922
11	vocalization behavior (GO:0071625)	4.55408675
12	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.55130277
13	neuron cell-cell adhesion (GO:0007158)	4.47016092
14	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.42843187
15	regulation of synaptic vesicle transport (GO:1902803)	4.36001899
16	neuronal action potential propagation (GO:0019227)	4.27504301
17	regulation of synapse structural plasticity (GO:0051823)	4.26266525
18	protein localization to synapse (GO:0035418)	4.26157967
19	pyrimidine nucleobase catabolic process (GO:0006208)	4.26053233
20	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.22416179
21	synaptic transmission, glutamatergic (GO:0035249)	4.14548735
22	dendritic spine morphogenesis (GO:0060997)	4.14109072
23	neurotransmitter-gated ion channel clustering (GO:0072578)	4.04989482
24	locomotory exploration behavior (GO:0035641)	4.04416784
25	presynaptic membrane organization (GO:0097090)	4.00670836
26	presynaptic membrane assembly (GO:0097105)	3.99983408
27	gamma-aminobutyric acid transport (GO:0015812)	3.97297566
28	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.91360409
29	cellular potassium ion homeostasis (GO:0030007)	3.88572836
30	exploration behavior (GO:0035640)	3.78094762
31	establishment of mitochondrion localization (GO:0051654)	3.77929990
32	regulation of neuronal synaptic plasticity (GO:0048168)	3.76027571
33	auditory behavior (GO:0031223)	3.72358534
34	neuron-neuron synaptic transmission (GO:0007270)	3.67411886
35	neuronal ion channel clustering (GO:0045161)	3.66723809
36	cell migration in hindbrain (GO:0021535)	3.63956491
37	glutamate receptor signaling pathway (GO:0007215)	3.62885630
38	cerebellar granule cell differentiation (GO:0021707)	3.61561446
39	neuron recognition (GO:0008038)	3.60799251
40	neurotransmitter transport (GO:0006836)	3.60554415
41	nucleobase catabolic process (GO:0046113)	3.59404580
42	axonal fasciculation (GO:0007413)	3.59260339
43	positive regulation of synapse maturation (GO:0090129)	3.53351591
44	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.48852180
45	regulation of glutamate receptor signaling pathway (GO:1900449)	3.44300043
46	regulation of neurotransmitter levels (GO:0001505)	3.41664964
47	synaptic vesicle endocytosis (GO:0048488)	3.40967409
48	regulation of long-term neuronal synaptic plasticity (GO:0048169)	3.33800597
49	sodium ion export (GO:0071436)	3.32909326
50	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.32051487
51	regulation of neurotransmitter secretion (GO:0046928)	3.28424414
52	transmission of nerve impulse (GO:0019226)	3.28290393
53	positive regulation of dendritic spine development (GO:0060999)	3.26870353
54	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.26824800
55	regulation of vesicle fusion (GO:0031338)	3.24694892
56	positive regulation of synapse assembly (GO:0051965)	3.24053941
57	axon ensheathment in central nervous system (GO:0032291)	3.23948731
58	central nervous system myelination (GO:0022010)	3.23948731
59	positive regulation of membrane potential (GO:0045838)	3.23552019
60	neuromuscular synaptic transmission (GO:0007274)	3.19545088
61	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.19510198
62	regulation of dendritic spine morphogenesis (GO:0061001)	3.17332107
63	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.15956978
64	regulation of neurotransmitter transport (GO:0051588)	3.11812308
65	dendritic spine organization (GO:0097061)	3.10330256
66	response to auditory stimulus (GO:0010996)	3.07134396
67	regulation of postsynaptic membrane potential (GO:0060078)	3.06282563
68	regulation of voltage-gated calcium channel activity (GO:1901385)	3.05036016
69	positive regulation of neurotransmitter transport (GO:0051590)	3.02581200
70	membrane depolarization during action potential (GO:0086010)	3.01072274
71	dendrite morphogenesis (GO:0048813)	2.98415000
72	synapse assembly (GO:0007416)	2.98177393
73	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.98005135
74	regulation of dendritic spine development (GO:0060998)	2.96405549
75	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.96291356
76	regulation of synapse maturation (GO:0090128)	2.96037259
77	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.95558758
78	layer formation in cerebral cortex (GO:0021819)	2.94886686
79	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.94319209
80	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.94123331
81	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.92443618
82	mechanosensory behavior (GO:0007638)	2.89678863
83	regulation of synaptic plasticity (GO:0048167)	2.88218064
84	L-amino acid import (GO:0043092)	2.86964706
85	membrane depolarization (GO:0051899)	2.86882278
86	mitochondrion transport along microtubule (GO:0047497)	2.85704439
87	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.85704439
88	amino acid import (GO:0043090)	2.83731168
89	synaptic transmission (GO:0007268)	2.83076930
90	startle response (GO:0001964)	2.82250147
91	positive regulation of neurotransmitter secretion (GO:0001956)	2.81948750
92	synaptic vesicle transport (GO:0048489)	2.81121134
93	establishment of synaptic vesicle localization (GO:0097480)	2.81121134
94	potassium ion homeostasis (GO:0055075)	2.79402565
95	regulation of synapse assembly (GO:0051963)	2.78133576
96	regulation of respiratory system process (GO:0044065)	2.77749615
97	central nervous system projection neuron axonogenesis (GO:0021952)	2.77579151
98	neuromuscular process controlling balance (GO:0050885)	2.76715075
99	detection of calcium ion (GO:0005513)	2.76082903
100	proline transport (GO:0015824)	2.75931365

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.70114644
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.33121087
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.05588463
4	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.96785032
5	REST_21632747_ChIP-Seq_MESCs_Mouse	2.93763279
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.73100822
7	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.68016450
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.65319186
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65078636
10	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.58073878
11	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.49971372
12	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.44700771
13	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.41240955
14	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.41240955
15	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.40923700
16	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.38397707
17	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.36289729
18	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.33388204
19	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.28501602
20	DROSHA_22980978_ChIP-Seq_HELA_Human	2.27560256
21	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.27443226
22	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.24001306
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.22324970
24	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.20047262
25	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.04646452
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.94407076
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.92013212
28	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.87578345
29	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71697563
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70597929
31	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.51814707
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.51356702
33	RNF2_27304074_Chip-Seq_NSC_Mouse	1.50510064
34	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.50452494
35	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.49373023
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49145606
37	TAF15_26573619_Chip-Seq_HEK293_Human	1.47541884
38	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.45793277
39	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.44055438
40	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.43375025
41	* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.41345747
42	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.40324885
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.39976346
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38987084
45	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.38849184
46	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.38608237
47	ZNF274_21170338_ChIP-Seq_K562_Hela	1.35827001
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29669094
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.27672821
50	P300_19829295_ChIP-Seq_ESCs_Human	1.26603712
51	AR_21572438_ChIP-Seq_LNCaP_Human	1.24593540
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18940919
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15960506
54	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.15378149
55	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.14537331
56	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.14510639
57	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.14359346
58	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.13774945
59	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13490556
60	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.11147606
61	AR_25329375_ChIP-Seq_VCAP_Human	1.09919143
62	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.07869620
63	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.06052541
64	* AR_19668381_ChIP-Seq_PC3_Human	1.04836527
65	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.04537030
66	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01500079
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01468598
68	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.01110541
69	STAT3_23295773_ChIP-Seq_U87_Human	1.01012708
70	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.00135058
71	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00135058
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00132937
73	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.99571809
74	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.99421999
75	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.99175802
76	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.98795553
77	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97021477
78	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.95884575
79	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95491211
80	* TCF4_23295773_ChIP-Seq_U87_Human	0.95085267
81	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.94937104
82	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.93390429
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92025913
84	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.91931664
85	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.91503749
86	SOX9_26525672_Chip-Seq_HEART_Mouse	0.90871564
87	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.90172235
88	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.90094082
89	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.89967693
90	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.89885783
91	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.89649445
92	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.89303235
93	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.88109663
94	CTCF_27219007_Chip-Seq_Bcells_Human	0.87633878
95	VDR_22108803_ChIP-Seq_LS180_Human	0.87480119
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.86927461
97	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.86339600
98	JUN_21703547_ChIP-Seq_K562_Human	0.86335774
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.84840833
100	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.84576707

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	5.39018110
2	MP0003880_abnormal_central_pattern	4.43326460
3	MP0004270_analgesia	3.84213939
4	MP0003635_abnormal_synaptic_transmissio	3.44593646
5	MP0005423_abnormal_somatic_nervous	3.15595949
6	MP0002064_seizures	2.95472803
7	MP0009745_abnormal_behavioral_response	2.89975267
8	MP0002063_abnormal_learning/memory/cond	2.81188916
9	MP0002734_abnormal_mechanical_nocicepti	2.64929948
10	MP0002272_abnormal_nervous_system	2.63627398
11	MP0009046_muscle_twitch	2.58759826
12	MP0001968_abnormal_touch/_nociception	2.55903301
13	MP0002572_abnormal_emotion/affect_behav	2.48677313
14	MP0001486_abnormal_startle_reflex	2.45377550
15	MP0003787_abnormal_imprinting	2.23191881
16	MP0000778_abnormal_nervous_system	2.22526713
17	MP0003122_maternal_imprinting	2.15496178
18	MP0002735_abnormal_chemical_nociception	2.15292564
19	MP0002736_abnormal_nociception_after	2.08214454
20	MP0001984_abnormal_olfaction	2.06551483
21	MP0006276_abnormal_autonomic_nervous	1.92573266
22	MP0009780_abnormal_chondrocyte_physiolo	1.89554895
23	MP0001970_abnormal_pain_threshold	1.89250294
24	MP0002822_catalepsy	1.86959721
25	MP0001529_abnormal_vocalization	1.84565465
26	MP0002733_abnormal_thermal_nociception	1.83572316
27	MP0001501_abnormal_sleep_pattern	1.80114617
28	MP0002557_abnormal_social/conspecific_i	1.72393833
29	MP0008569_lethality_at_weaning	1.70934604
30	MP0004885_abnormal_endolymph	1.70757093
31	MP0004811_abnormal_neuron_physiology	1.70622552
32	MP0002067_abnormal_sensory_capabilities	1.64897029
33	MP0000955_abnormal_spinal_cord	1.53908676
34	MP0001905_abnormal_dopamine_level	1.51991443
35	MP0005386_behavior/neurological_phenoty	1.50575958
36	MP0004924_abnormal_behavior	1.50575958
37	MP0003329_amyloid_beta_deposits	1.49337446
38	MP0002882_abnormal_neuron_morphology	1.49144147
39	MP0002184_abnormal_innervation	1.47027370
40	MP0001502_abnormal_circadian_rhythm	1.44758814
41	MP0001440_abnormal_grooming_behavior	1.43433185
42	MP0003879_abnormal_hair_cell	1.38573159
43	MP0002066_abnormal_motor_capabilities/c	1.37524890
44	MP0005646_abnormal_pituitary_gland	1.34392743
45	MP0003121_genomic_imprinting	1.27435617
46	MP0001188_hyperpigmentation	1.24588758
47	MP0003633_abnormal_nervous_system	1.23181517
48	MP0004142_abnormal_muscle_tone	1.20842796
49	MP0005551_abnormal_eye_electrophysiolog	1.17165163
50	MP0005499_abnormal_olfactory_system	1.14857607
51	MP0005394_taste/olfaction_phenotype	1.14857607
52	MP0002152_abnormal_brain_morphology	1.12868224
53	MP0002909_abnormal_adrenal_gland	1.10927791
54	MP0008877_abnormal_DNA_methylation	1.10765595
55	MP0002102_abnormal_ear_morphology	1.10471053
56	MP0002653_abnormal_ependyma_morphology	1.09291653
57	MP0000751_myopathy	1.06302919
58	MP0001177_atelectasis	1.06123565
59	MP0003631_nervous_system_phenotype	1.06013412
60	MP0001299_abnormal_eye_distance/	1.03930406
61	MP0002638_abnormal_pupillary_reflex	1.02806774
62	MP0004742_abnormal_vestibular_system	0.98314770
63	MP0002752_abnormal_somatic_nervous	0.95598163
64	MP0010386_abnormal_urinary_bladder	0.94308025
65	MP0002229_neurodegeneration	0.93513020
66	MP0002069_abnormal_eating/drinking_beha	0.92489452
67	MP0005645_abnormal_hypothalamus_physiol	0.92377153
68	MP0001963_abnormal_hearing_physiology	0.92059010
69	MP0003634_abnormal_glial_cell	0.89757735
70	MP0000920_abnormal_myelination	0.89561520
71	MP0003123_paternal_imprinting	0.85604887
72	MP0000631_abnormal_neuroendocrine_gland	0.84375332
73	MP0008789_abnormal_olfactory_epithelium	0.83336615
74	MP0000026_abnormal_inner_ear	0.80604937
75	MP0003632_abnormal_nervous_system	0.78389629
76	MP0002837_dystrophic_cardiac_calcinosis	0.77687399
77	MP0001485_abnormal_pinna_reflex	0.76643142
78	MP0003861_abnormal_nervous_system	0.75963071
79	MP0006072_abnormal_retinal_apoptosis	0.75798580
80	MP0004145_abnormal_muscle_electrophysio	0.75778488
81	MP0003011_delayed_dark_adaptation	0.74391931
82	MP0003137_abnormal_impulse_conducting	0.73811504
83	MP0005623_abnormal_meninges_morphology	0.71425015
84	MP0000049_abnormal_middle_ear	0.70439025
85	MP0003690_abnormal_glial_cell	0.67980028
86	MP0004133_heterotaxia	0.67445179
87	MP0005253_abnormal_eye_physiology	0.66547912
88	MP0001986_abnormal_taste_sensitivity	0.66456191
89	MP0004085_abnormal_heartbeat	0.66435722
90	MP0006292_abnormal_olfactory_placode	0.63405238
91	MP0003938_abnormal_ear_development	0.61694821
92	MP0004215_abnormal_myocardial_fiber	0.61224561
93	MP0004147_increased_porphyrin_level	0.61173683
94	MP0001943_abnormal_respiration	0.60508197
95	MP0002082_postnatal_lethality	0.56462835
96	MP0010770_preweaning_lethality	0.56462835
97	MP0010769_abnormal_survival	0.55745163
98	MP0002751_abnormal_autonomic_nervous	0.55742657
99	MP0000566_synostosis	0.54501140
100	MP0003283_abnormal_digestive_organ	0.53593147

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	6.52984233
2	Focal motor seizures (HP:0011153)	5.93415918
3	Focal seizures (HP:0007359)	5.10398838
4	Limb dystonia (HP:0002451)	4.28208986
5	Febrile seizures (HP:0002373)	4.21125589
6	Epileptic encephalopathy (HP:0200134)	4.18766013
7	Atonic seizures (HP:0010819)	4.01393434
8	Action tremor (HP:0002345)	3.97349057
9	Polyphagia (HP:0002591)	3.70928788
10	Abnormal eating behavior (HP:0100738)	3.64149129
11	Progressive cerebellar ataxia (HP:0002073)	3.49321532
12	Generalized tonic-clonic seizures (HP:0002069)	3.47118557
13	Ankle clonus (HP:0011448)	3.31412836
14	Supranuclear gaze palsy (HP:0000605)	3.22448160
15	Torticollis (HP:0000473)	3.19515247
16	Dialeptic seizures (HP:0011146)	3.10546736
17	Hemiparesis (HP:0001269)	3.05720250
18	Spastic gait (HP:0002064)	3.04184181
19	Impaired vibration sensation in the lower limbs (HP:0002166)	2.98199732
20	Absence seizures (HP:0002121)	2.97364765
21	Epileptiform EEG discharges (HP:0011182)	2.84493482
22	Drooling (HP:0002307)	2.81940594
23	Diplopia (HP:0000651)	2.79905998
24	Abnormality of binocular vision (HP:0011514)	2.79905998
25	Focal dystonia (HP:0004373)	2.78710664
26	Urinary urgency (HP:0000012)	2.70796537
27	Cerebral hypomyelination (HP:0006808)	2.67049937
28	EEG with generalized epileptiform discharges (HP:0011198)	2.66903916
29	Abnormality of the corticospinal tract (HP:0002492)	2.64614753
30	Gait imbalance (HP:0002141)	2.64387160
31	Sleep apnea (HP:0010535)	2.61395479
32	Mutism (HP:0002300)	2.61039160
33	Hypsarrhythmia (HP:0002521)	2.57408254
34	Hyperventilation (HP:0002883)	2.55663284
35	Broad-based gait (HP:0002136)	2.55653864
36	Excessive salivation (HP:0003781)	2.53471381
37	Urinary bladder sphincter dysfunction (HP:0002839)	2.51885583
38	Amblyopia (HP:0000646)	2.51286328
39	Craniofacial dystonia (HP:0012179)	2.45702592
40	Absent speech (HP:0001344)	2.43968342
41	Intention tremor (HP:0002080)	2.37165532
42	Retinal dysplasia (HP:0007973)	2.37076166
43	Neurofibrillary tangles (HP:0002185)	2.35693769
44	Split foot (HP:0001839)	2.35619908
45	Visual hallucinations (HP:0002367)	2.34041151
46	Truncal ataxia (HP:0002078)	2.30731205
47	Lower limb muscle weakness (HP:0007340)	2.30606875
48	Abnormality of the lower motor neuron (HP:0002366)	2.29054568
49	Status epilepticus (HP:0002133)	2.28332283
50	Spastic tetraplegia (HP:0002510)	2.25880712
51	Anxiety (HP:0000739)	2.23818224
52	Akinesia (HP:0002304)	2.23798011
53	Dysmetria (HP:0001310)	2.18916508
54	Type II lissencephaly (HP:0007260)	2.16010245
55	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.14549186
56	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.14549186
57	Hand muscle atrophy (HP:0009130)	2.13722914
58	Abnormality of the labia minora (HP:0012880)	2.12142920
59	Lissencephaly (HP:0001339)	2.10788844
60	Delusions (HP:0000746)	2.09304473
61	Specific learning disability (HP:0001328)	2.08983816
62	Poor eye contact (HP:0000817)	2.08724895
63	Medial flaring of the eyebrow (HP:0010747)	2.04908663
64	Failure to thrive in infancy (HP:0001531)	2.04660136
65	Postural instability (HP:0002172)	2.04163732
66	Hemiplegia (HP:0002301)	2.01964588
67	Papilledema (HP:0001085)	2.00335108
68	Morphological abnormality of the pyramidal tract (HP:0002062)	1.99282225
69	Amyotrophic lateral sclerosis (HP:0007354)	1.94482608
70	Depression (HP:0000716)	1.93856578
71	Hypoventilation (HP:0002791)	1.93112620
72	Congenital primary aphakia (HP:0007707)	1.92544494
73	Poor suck (HP:0002033)	1.86670038
74	Esotropia (HP:0000565)	1.85381963
75	Clonus (HP:0002169)	1.84463301
76	Incomplete penetrance (HP:0003829)	1.83840949
77	Optic nerve hypoplasia (HP:0000609)	1.80989214
78	Pachygyria (HP:0001302)	1.80938653
79	Dysdiadochokinesis (HP:0002075)	1.80260759
80	CNS hypomyelination (HP:0003429)	1.80096044
81	Gaze-evoked nystagmus (HP:0000640)	1.79910677
82	Nephrogenic diabetes insipidus (HP:0009806)	1.78818811
83	Hypoplasia of the corpus callosum (HP:0002079)	1.78613837
84	Fetal akinesia sequence (HP:0001989)	1.77115289
85	Agitation (HP:0000713)	1.76309413
86	Bradykinesia (HP:0002067)	1.72619854
87	Megalencephaly (HP:0001355)	1.72543175
88	Inability to walk (HP:0002540)	1.71733628
89	Abnormal social behavior (HP:0012433)	1.71586152
90	Impaired social interactions (HP:0000735)	1.71586152
91	Peripheral hypomyelination (HP:0007182)	1.71341442
92	Cerebral inclusion bodies (HP:0100314)	1.69715616
93	Hypoplasia of the brainstem (HP:0002365)	1.69608350
94	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.69608350
95	Upper limb amyotrophy (HP:0009129)	1.65430659
96	Distal upper limb amyotrophy (HP:0007149)	1.65430659
97	Tetraplegia (HP:0002445)	1.65248395
98	Impaired vibratory sensation (HP:0002495)	1.63852701
99	Spastic tetraparesis (HP:0001285)	1.62824805
100	Obstructive sleep apnea (HP:0002870)	1.61675553

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	5.33999167
2	EPHA4	4.18800437
3	CASK	3.49393607
4	PAK6	3.36170303
5	NTRK3	3.20430072
6	DAPK2	2.78698531
7	NTRK2	2.73275226
8	UHMK1	2.26469460
9	MAPK13	2.25264715
10	MAP3K4	2.18203179
11	MINK1	2.11442678
12	PRKD3	2.05541228
13	MAP2K7	1.88914231
14	PHKG1	1.87798247
15	PHKG2	1.87798247
16	PAK3	1.74038754
17	NTRK1	1.71912620
18	PLK2	1.70299906
19	PINK1	1.70243722
20	WNK3	1.62336499
21	MAP3K9	1.55591701
22	LIMK1	1.54458137
23	CAMKK1	1.50100382
24	DYRK2	1.49817576
25	PRKCG	1.49402061
26	CDK5	1.46966527
27	CDK19	1.33783534
28	SIK2	1.22207541
29	CAMK2B	1.19620322
30	GRK5	1.17615906
31	CSNK1G2	1.17562767
32	TESK1	1.13585946
33	MAP2K4	1.11314433
34	SGK223	1.08977246
35	SGK494	1.08977246
36	CAMK2A	1.08004263
37	CAMK1	1.07444716
38	CAMKK2	1.06214596
39	BCR	1.02642034
40	DYRK1A	1.00455706
41	CDK15	0.99808192
42	MAP4K2	0.99295984
43	CDK18	0.98812843
44	CDK14	0.98395499
45	PKN1	0.98155867
46	PNCK	0.93874974
47	EPHB2	0.93763966
48	CDK11A	0.93696421
49	CAMK2G	0.86547856
50	TYRO3	0.86131520
51	DAPK1	0.83920803
52	LATS2	0.83601581
53	CSNK1G3	0.81152232
54	KSR1	0.80697858
55	STK38	0.77666730
56	PRKCE	0.76255496
57	TNIK	0.74811872
58	PRKCH	0.74007862
59	STK11	0.70582293
60	CAMK2D	0.68481968
61	SGK2	0.67700416
62	CSNK1A1L	0.64129122
63	MARK2	0.61909282
64	CSNK1G1	0.61610521
65	CAMK4	0.60446021
66	TRIM28	0.59987283
67	ARAF	0.59375507
68	OXSR1	0.58413817
69	PRKCZ	0.57336320
70	ADRBK2	0.54612093
71	ROCK2	0.54025186
72	KSR2	0.53296052
73	SGK1	0.52168669
74	FRK	0.51050947
75	STK38L	0.50198441
76	INSRR	0.49380291
77	MAP3K12	0.49145660
78	CCNB1	0.48921555
79	FGFR2	0.48785997
80	RPS6KA3	0.47621083
81	WNK4	0.46969806
82	DDR2	0.46916660
83	ROCK1	0.45371383
84	PRKG1	0.44083220
85	PRKACA	0.43939558
86	DAPK3	0.43497490
87	MAPK12	0.41844495
88	ERBB3	0.41522310
89	GRK1	0.41249566
90	MAPK10	0.38819102
91	CSNK1A1	0.38492946
92	CSNK1D	0.37734589
93	MAPKAPK5	0.36988128
94	CSNK1E	0.36355671
95	ADRBK1	0.36170733
96	SGK3	0.32928784
97	PRKCA	0.32130558
98	LMTK2	0.31566509
99	DYRK1B	0.30215084
100	EPHA3	0.30157063

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.25144658
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.74798425
3	GABAergic synapse_Homo sapiens_hsa04727	2.98826256
4	Circadian entrainment_Homo sapiens_hsa04713	2.68499006
5	Morphine addiction_Homo sapiens_hsa05032	2.62091590
6	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.59499022
7	Glutamatergic synapse_Homo sapiens_hsa04724	2.57677622
8	Amphetamine addiction_Homo sapiens_hsa05031	2.52819754
9	Insulin secretion_Homo sapiens_hsa04911	2.41142324
10	Dopaminergic synapse_Homo sapiens_hsa04728	2.28199124
11	Cocaine addiction_Homo sapiens_hsa05030	2.22595755
12	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.96624289
13	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.96234876
14	Long-term potentiation_Homo sapiens_hsa04720	1.90602395
15	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.77802156
16	Gastric acid secretion_Homo sapiens_hsa04971	1.68995583
17	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.67729964
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.65014854
19	Cholinergic synapse_Homo sapiens_hsa04725	1.62284355
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.55625176
21	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.55426197
22	Salivary secretion_Homo sapiens_hsa04970	1.54547047
23	Taste transduction_Homo sapiens_hsa04742	1.51256560
24	Phototransduction_Homo sapiens_hsa04744	1.44250071
25	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.41864947
26	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.40615543
27	Long-term depression_Homo sapiens_hsa04730	1.34376934
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.31285320
29	cAMP signaling pathway_Homo sapiens_hsa04024	1.30926237
30	Axon guidance_Homo sapiens_hsa04360	1.29318691
31	Serotonergic synapse_Homo sapiens_hsa04726	1.25792868
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.20348282
33	Renin secretion_Homo sapiens_hsa04924	1.17913311
34	Olfactory transduction_Homo sapiens_hsa04740	1.16660111
35	Vibrio cholerae infection_Homo sapiens_hsa05110	1.16441651
36	Gap junction_Homo sapiens_hsa04540	1.16106124
37	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.10617821
38	Oxidative phosphorylation_Homo sapiens_hsa00190	1.09549099
39	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.02772254
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.02057313
41	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.98523692
42	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.95249077
43	Butanoate metabolism_Homo sapiens_hsa00650	0.94299373
44	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.93093849
45	Melanogenesis_Homo sapiens_hsa04916	0.92140613
46	Alzheimers disease_Homo sapiens_hsa05010	0.87631019
47	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.87486777
48	Parkinsons disease_Homo sapiens_hsa05012	0.87437729
49	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.84193352
50	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.83355862
51	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.81982499
52	Estrogen signaling pathway_Homo sapiens_hsa04915	0.80166299
53	Oocyte meiosis_Homo sapiens_hsa04114	0.79728513
54	Circadian rhythm_Homo sapiens_hsa04710	0.76383853
55	GnRH signaling pathway_Homo sapiens_hsa04912	0.74101852
56	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.73950045
57	Pancreatic secretion_Homo sapiens_hsa04972	0.70701988
58	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.69788038
59	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.68789601
60	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.66216211
61	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.64022198
62	Regulation of autophagy_Homo sapiens_hsa04140	0.63382186
63	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62086528
64	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.60117605
65	Ras signaling pathway_Homo sapiens_hsa04014	0.58699885
66	Glioma_Homo sapiens_hsa05214	0.57622351
67	Bile secretion_Homo sapiens_hsa04976	0.56509742
68	Hippo signaling pathway_Homo sapiens_hsa04390	0.56377365
69	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.56282982
70	Type II diabetes mellitus_Homo sapiens_hsa04930	0.56263352
71	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.54876471
72	Rap1 signaling pathway_Homo sapiens_hsa04015	0.52159802
73	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.50763812
74	Glucagon signaling pathway_Homo sapiens_hsa04922	0.49585212
75	Tight junction_Homo sapiens_hsa04530	0.48565876
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.47125643
77	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.47014872
78	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.46505771
79	Huntingtons disease_Homo sapiens_hsa05016	0.46281402
80	ErbB signaling pathway_Homo sapiens_hsa04012	0.46000329
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45117814
82	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43937890
83	Wnt signaling pathway_Homo sapiens_hsa04310	0.43857149
84	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.42564373
85	Alcoholism_Homo sapiens_hsa05034	0.38172414
86	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36577316
87	AMPK signaling pathway_Homo sapiens_hsa04152	0.35226936
88	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33361212
89	Prion diseases_Homo sapiens_hsa05020	0.33189580
90	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.32777669
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31446402
92	Endocytosis_Homo sapiens_hsa04144	0.29853337
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.29497991
94	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28957001
95	Protein export_Homo sapiens_hsa03060	0.28515441
96	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.28489187
97	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27371842
98	Protein digestion and absorption_Homo sapiens_hsa04974	0.25607902
99	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.24900842
100	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.24897405

C16ORF45

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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