ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.94593051
2	glutamate secretion (GO:0014047)	4.87144234
3	synaptic vesicle docking involved in exocytosis (GO:0016081)	4.79415649
4	cellular potassium ion homeostasis (GO:0030007)	4.76772118
5	synaptic vesicle maturation (GO:0016188)	4.74286375
6	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.59156741
7	positive regulation of dendritic spine morphogenesis (GO:0061003)	4.51542719
8	sodium ion export (GO:0071436)	4.42929876
9	short-term memory (GO:0007614)	4.04376741
10	ionotropic glutamate receptor signaling pathway (GO:0035235)	3.92015955
11	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.90519669
12	neuron recognition (GO:0008038)	3.85018785
13	synaptic vesicle exocytosis (GO:0016079)	3.79579472
14	neuronal action potential propagation (GO:0019227)	3.72313948
15	protein localization to synapse (GO:0035418)	3.67874842
16	synaptic transmission, glutamatergic (GO:0035249)	3.64041854
17	motile cilium assembly (GO:0044458)	3.60645681
18	exploration behavior (GO:0035640)	3.60054269
19	locomotory exploration behavior (GO:0035641)	3.59993368
20	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	3.58976500
21	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.56895062
22	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.52530385
23	glutamate receptor signaling pathway (GO:0007215)	3.47106187
24	regulation of synaptic vesicle exocytosis (GO:2000300)	3.41406559
25	neurotransmitter secretion (GO:0007269)	3.36797011
26	neuron-neuron synaptic transmission (GO:0007270)	3.34725454
27	axonal fasciculation (GO:0007413)	3.33350784
28	positive regulation of synapse maturation (GO:0090129)	3.33248040
29	cellular sodium ion homeostasis (GO:0006883)	3.33224668
30	layer formation in cerebral cortex (GO:0021819)	3.29948676
31	regulation of dendritic spine morphogenesis (GO:0061001)	3.28680434
32	gamma-aminobutyric acid transport (GO:0015812)	3.26536534
33	negative regulation of dendrite morphogenesis (GO:0050774)	3.25889910
34	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.24298170
35	regulation of synaptic vesicle transport (GO:1902803)	3.22243414
36	potassium ion homeostasis (GO:0055075)	3.18745625
37	cerebellar granule cell differentiation (GO:0021707)	3.16863998
38	cell communication by electrical coupling (GO:0010644)	3.11237583
39	positive regulation of dendritic spine development (GO:0060999)	3.10968914
40	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.09239660
41	neurotransmitter-gated ion channel clustering (GO:0072578)	3.04009945
42	postsynaptic membrane organization (GO:0001941)	3.03792248
43	membrane depolarization during action potential (GO:0086010)	3.02862516
44	axon ensheathment in central nervous system (GO:0032291)	3.00826613
45	central nervous system myelination (GO:0022010)	3.00826613
46	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.97756884
47	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.97530844
48	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.96800677
49	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.95770166
50	regulation of voltage-gated calcium channel activity (GO:1901385)	2.94928185
51	regulation of long-term neuronal synaptic plasticity (GO:0048169)	2.92793937
52	regulation of neuronal synaptic plasticity (GO:0048168)	2.90145262
53	vocalization behavior (GO:0071625)	2.89545438
54	detection of calcium ion (GO:0005513)	2.88666535
55	potassium ion import (GO:0010107)	2.88638300
56	neuromuscular synaptic transmission (GO:0007274)	2.86205520
57	regulation of synapse maturation (GO:0090128)	2.84126380
58	regulation of dendritic spine development (GO:0060998)	2.82825311
59	behavioral defense response (GO:0002209)	2.81688537
60	behavioral fear response (GO:0001662)	2.81688537
61	regulation of neurotransmitter secretion (GO:0046928)	2.80087510
62	regulation of synapse assembly (GO:0051963)	2.78488281
63	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.76622317
64	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	2.75542978
65	regulation of postsynaptic membrane potential (GO:0060078)	2.74706529
66	membrane depolarization (GO:0051899)	2.74328896
67	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.72033981
68	positive regulation of synapse assembly (GO:0051965)	2.71495457
69	dendrite morphogenesis (GO:0048813)	2.68468566
70	dendrite development (GO:0016358)	2.66368012
71	adult walking behavior (GO:0007628)	2.64096535
72	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.63067341
73	behavioral response to cocaine (GO:0048148)	2.61665270
74	cerebellar Purkinje cell differentiation (GO:0021702)	2.60645736
75	neuronal ion channel clustering (GO:0045161)	2.59835063
76	regulation of cAMP-dependent protein kinase activity (GO:2000479)	2.57919693
77	regulation of neurotransmitter transport (GO:0051588)	2.57584996
78	regulation of glutamate receptor signaling pathway (GO:1900449)	2.57308007
79	neurotransmitter transport (GO:0006836)	2.57026490
80	fear response (GO:0042596)	2.56877907
81	negative regulation of sodium ion transport (GO:0010766)	2.55104515
82	cell communication involved in cardiac conduction (GO:0086065)	2.54622622
83	presynaptic membrane organization (GO:0097090)	2.54121123
84	chemosensory behavior (GO:0007635)	2.53868865
85	negative regulation of fatty acid transport (GO:2000192)	2.53864653
86	presynaptic membrane assembly (GO:0097105)	2.53718104
87	regulation of dendrite morphogenesis (GO:0048814)	2.51413312
88	neuron cell-cell adhesion (GO:0007158)	2.51307214
89	positive regulation of dendrite morphogenesis (GO:0050775)	2.50866624
90	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.49434379
91	chondrocyte proliferation (GO:0035988)	2.49362407
92	transmission of nerve impulse (GO:0019226)	2.48604612
93	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	2.46350036
94	regulation of vesicle fusion (GO:0031338)	2.46120461
95	regulation of synaptic plasticity (GO:0048167)	2.45628550
96	axon extension (GO:0048675)	2.45527394
97	cell migration in hindbrain (GO:0021535)	2.45168415
98	positive regulation of membrane potential (GO:0045838)	2.43400693
99	regulation of synapse organization (GO:0050807)	2.42770571
100	limb bud formation (GO:0060174)	2.42274265

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.44448188
2	EZH2_22144423_ChIP-Seq_EOC_Human	2.79125091
3	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.68188520
4	AR_21572438_ChIP-Seq_LNCaP_Human	2.51189149
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43895944
6	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.43890570
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.23629279
8	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.17859557
9	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.16965767
10	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.14178090
11	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.06874847
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.05885753
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.04282574
14	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.01646818
15	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.97562643
16	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.97562643
17	VDR_22108803_ChIP-Seq_LS180_Human	1.96212646
18	FUS_26573619_Chip-Seq_HEK293_Human	1.94647612
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.94231495
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.90595288
21	REST_21632747_ChIP-Seq_MESCs_Mouse	1.88727352
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88491591
23	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.86829037
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.83626687
25	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.81395446
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.81380176
27	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.80327177
28	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.79186883
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78532693
30	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.78224705
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.71322308
32	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.69822706
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.69182801
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.68839052
35	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.67091811
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.66042888
37	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.63632466
38	P300_19829295_ChIP-Seq_ESCs_Human	1.62611372
39	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62418197
40	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59714897
41	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57233835
42	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.53022195
43	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51969296
44	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.51027283
45	TP53_16413492_ChIP-PET_HCT116_Human	1.50566007
46	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.49996928
47	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.48855733
48	* STAT3_23295773_ChIP-Seq_U87_Human	1.48385671
49	RNF2_27304074_Chip-Seq_NSC_Mouse	1.47889243
50	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.47738913
51	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.47539235
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.45175821
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44571336
54	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.44234490
55	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.40381707
56	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.39940620
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39807715
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.37877612
59	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37259996
60	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.36902587
61	EWS_26573619_Chip-Seq_HEK293_Human	1.35627230
62	* TCF4_23295773_ChIP-Seq_U87_Human	1.35390698
63	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.33604250
64	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33294942
65	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.29096597
66	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.29096597
67	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.27990759
68	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27928094
69	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.27661327
70	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26513828
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26513828
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25523553
73	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25109783
74	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25072214
75	TP53_18474530_ChIP-ChIP_U2OS_Human	1.24800915
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.23359620
77	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.23121312
78	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.22067213
79	AHR_22903824_ChIP-Seq_MCF-7_Human	1.21630095
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21372569
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20899113
82	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.18826612
83	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17523766
84	ER_23166858_ChIP-Seq_MCF-7_Human	1.16983972
85	AR_25329375_ChIP-Seq_VCAP_Human	1.14770763
86	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.14631472
87	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13255009
88	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.13238797
89	IGF1R_20145208_ChIP-Seq_DFB_Human	1.12233546
90	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.11731504
91	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.11262971
92	KDM2B_26808549_Chip-Seq_REH_Human	1.11114384
93	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.11105078
94	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.11100128
95	DROSHA_22980978_ChIP-Seq_HELA_Human	1.11085380
96	* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.09569646
97	AR_19668381_ChIP-Seq_PC3_Human	1.08150141
98	RUNX2_22187159_ChIP-Seq_PCA_Human	1.05736940
99	SOX9_26525672_Chip-Seq_HEART_Mouse	1.05245870
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04242330

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	4.54089499
2	MP0003880_abnormal_central_pattern	3.79275028
3	MP0003123_paternal_imprinting	3.68005161
4	MP0009046_muscle_twitch	3.11714819
5	MP0003635_abnormal_synaptic_transmissio	3.08506927
6	MP0004270_analgesia	2.89507412
7	MP0005423_abnormal_somatic_nervous	2.68245572
8	MP0002064_seizures	2.61301823
9	MP0002272_abnormal_nervous_system	2.59257899
10	MP0002063_abnormal_learning/memory/cond	2.42256430
11	MP0009745_abnormal_behavioral_response	2.39469571
12	MP0000569_abnormal_digit_pigmentation	2.37075930
13	MP0001486_abnormal_startle_reflex	2.11934024
14	MP0001501_abnormal_sleep_pattern	2.05091863
15	MP0002572_abnormal_emotion/affect_behav	1.97356479
16	MP0009780_abnormal_chondrocyte_physiolo	1.96639383
17	MP0002734_abnormal_mechanical_nocicepti	1.93185315
18	MP0000778_abnormal_nervous_system	1.79053716
19	MP0002735_abnormal_chemical_nociception	1.78805523
20	MP0008569_lethality_at_weaning	1.76974301
21	MP0003121_genomic_imprinting	1.74330667
22	MP0003122_maternal_imprinting	1.70338853
23	MP0001968_abnormal_touch/_nociception	1.66093925
24	MP0002184_abnormal_innervation	1.64187765
25	MP0002067_abnormal_sensory_capabilities	1.62163265
26	MP0001440_abnormal_grooming_behavior	1.62122716
27	MP0001299_abnormal_eye_distance/	1.48860789
28	MP0000955_abnormal_spinal_cord	1.43757469
29	MP0001970_abnormal_pain_threshold	1.40596079
30	MP0000534_abnormal_ureter_morphology	1.37259389
31	MP0002733_abnormal_thermal_nociception	1.36478061
32	MP0004811_abnormal_neuron_physiology	1.35645934
33	MP0001984_abnormal_olfaction	1.31846756
34	MP0008877_abnormal_DNA_methylation	1.29628831
35	MP0010386_abnormal_urinary_bladder	1.28346591
36	MP0002557_abnormal_social/conspecific_i	1.28272398
37	MP0002882_abnormal_neuron_morphology	1.25623684
38	MP0003890_abnormal_embryonic-extraembry	1.23564043
39	MP0001348_abnormal_lacrimal_gland	1.20505046
40	MP0003633_abnormal_nervous_system	1.19704612
41	MP0002066_abnormal_motor_capabilities/c	1.16710042
42	MP0002152_abnormal_brain_morphology	1.15298752
43	MP0004142_abnormal_muscle_tone	1.14912564
44	MP0001188_hyperpigmentation	1.14575173
45	MP0004885_abnormal_endolymph	1.11757926
46	MP0004924_abnormal_behavior	1.10452131
47	MP0005386_behavior/neurological_phenoty	1.10452131
48	MP0002736_abnormal_nociception_after	1.09259621
49	MP0002160_abnormal_reproductive_system	1.08721052
50	MP0003631_nervous_system_phenotype	1.05124488
51	MP0003787_abnormal_imprinting	1.04422084
52	MP0003942_abnormal_urinary_system	1.03319233
53	MP0004742_abnormal_vestibular_system	1.03063189
54	MP0005646_abnormal_pituitary_gland	1.02851219
55	MP0000537_abnormal_urethra_morphology	1.01803020
56	MP0000749_muscle_degeneration	1.00501150
57	MP0003315_abnormal_perineum_morphology	0.97639897
58	MP0003879_abnormal_hair_cell	0.97035711
59	MP0001502_abnormal_circadian_rhythm	0.96202462
60	MP0000516_abnormal_urinary_system	0.95664609
61	MP0005367_renal/urinary_system_phenotyp	0.95664609
62	MP0009250_abnormal_appendicular_skeleto	0.95539687
63	MP0005551_abnormal_eye_electrophysiolog	0.95520060
64	MP0004484_altered_response_of	0.94413985
65	MP0003861_abnormal_nervous_system	0.91487520
66	MP0005409_darkened_coat_color	0.90997051
67	MP0004215_abnormal_myocardial_fiber	0.90933403
68	MP0002638_abnormal_pupillary_reflex	0.89294431
69	MP0003385_abnormal_body_wall	0.87548445
70	MP0006276_abnormal_autonomic_nervous	0.86343711
71	MP0003632_abnormal_nervous_system	0.82324558
72	MP0003755_abnormal_palate_morphology	0.81160840
73	MP0000920_abnormal_myelination	0.80128292
74	MP0005503_abnormal_tendon_morphology	0.79389317
75	MP0005174_abnormal_tail_pigmentation	0.76582980
76	MP0002752_abnormal_somatic_nervous	0.76566167
77	MP0009384_cardiac_valve_regurgitation	0.76472439
78	MP0002108_abnormal_muscle_morphology	0.75159026
79	MP0000427_abnormal_hair_cycle	0.74511909
80	MP0008057_abnormal_DNA_replication	0.70898670
81	MP0004134_abnormal_chest_morphology	0.70820275
82	MP0008872_abnormal_physiological_respon	0.70659531
83	MP0003937_abnormal_limbs/digits/tail_de	0.70246855
84	MP0000639_abnormal_adrenal_gland	0.70064514
85	MP0004084_abnormal_cardiac_muscle	0.69830854
86	MP0004145_abnormal_muscle_electrophysio	0.69461081
87	MP0009379_abnormal_foot_pigmentation	0.68795748
88	MP0001485_abnormal_pinna_reflex	0.67955810
89	MP0003936_abnormal_reproductive_system	0.67945846
90	MP0005187_abnormal_penis_morphology	0.66195693
91	MP0000631_abnormal_neuroendocrine_gland	0.65664581
92	MP0003634_abnormal_glial_cell	0.65427651
93	MP0002822_catalepsy	0.65299896
94	MP0003329_amyloid_beta_deposits	0.64928178
95	MP0005670_abnormal_white_adipose	0.64452278
96	MP0002177_abnormal_outer_ear	0.64282047
97	MP0003941_abnormal_skin_development	0.64233985
98	MP0005620_abnormal_muscle_contractility	0.63490996
99	MP0004272_abnormal_basement_membrane	0.62590303
100	MP0001529_abnormal_vocalization	0.62495699

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	7.21829384
2	Febrile seizures (HP:0002373)	5.80475093
3	Focal seizures (HP:0007359)	5.18242494
4	Atonic seizures (HP:0010819)	5.04722955
5	Absence seizures (HP:0002121)	4.12802320
6	Myokymia (HP:0002411)	4.11722949
7	Epileptic encephalopathy (HP:0200134)	4.04059848
8	Dialeptic seizures (HP:0011146)	4.00988584
9	Generalized tonic-clonic seizures (HP:0002069)	3.57944403
10	Action tremor (HP:0002345)	3.53086539
11	Broad-based gait (HP:0002136)	2.94455751
12	Abnormality of the corticospinal tract (HP:0002492)	2.94433906
13	Progressive cerebellar ataxia (HP:0002073)	2.88657928
14	Urinary bladder sphincter dysfunction (HP:0002839)	2.82026981
15	Impaired vibration sensation in the lower limbs (HP:0002166)	2.74930644
16	Urinary urgency (HP:0000012)	2.69377241
17	Gaze-evoked nystagmus (HP:0000640)	2.57798006
18	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.56269206
19	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.56269206
20	Scanning speech (HP:0002168)	2.50870021
21	Drooling (HP:0002307)	2.36157203
22	Visual hallucinations (HP:0002367)	2.35793576
23	Absent speech (HP:0001344)	2.30167350
24	Spastic gait (HP:0002064)	2.27438945
25	Bundle branch block (HP:0011710)	2.22376446
26	Ankle clonus (HP:0011448)	2.22347483
27	Status epilepticus (HP:0002133)	2.20427847
28	Protruding tongue (HP:0010808)	2.13823691
29	Hyperventilation (HP:0002883)	2.13466328
30	Arterial tortuosity (HP:0005116)	2.11518485
31	Megalencephaly (HP:0001355)	2.08469855
32	Dysmetria (HP:0001310)	2.08293874
33	Akinesia (HP:0002304)	2.07808700
34	Excessive salivation (HP:0003781)	2.06982370
35	Aplasia involving bones of the extremities (HP:0009825)	2.06622370
36	Aplasia involving bones of the upper limbs (HP:0009823)	2.06622370
37	Aplasia of the phalanges of the hand (HP:0009802)	2.06622370
38	Postural instability (HP:0002172)	2.05201612
39	Genetic anticipation (HP:0003743)	2.04890789
40	Limb dystonia (HP:0002451)	2.04541903
41	Vascular tortuosity (HP:0004948)	2.00287454
42	Insidious onset (HP:0003587)	1.97006736
43	Termporal pattern (HP:0011008)	1.97006736
44	Epileptiform EEG discharges (HP:0011182)	1.94069067
45	Truncal ataxia (HP:0002078)	1.87224959
46	Failure to thrive in infancy (HP:0001531)	1.86910795
47	Exotropia (HP:0000577)	1.85832977
48	Supranuclear gaze palsy (HP:0000605)	1.82017042
49	Submucous cleft hard palate (HP:0000176)	1.81165594
50	Dysmetric saccades (HP:0000641)	1.80965900
51	Amblyopia (HP:0000646)	1.79440888
52	Impaired vibratory sensation (HP:0002495)	1.78658496
53	Lower limb muscle weakness (HP:0007340)	1.76024872
54	Torticollis (HP:0000473)	1.73594268
55	Limited hip movement (HP:0008800)	1.69838944
56	Microglossia (HP:0000171)	1.69170815
57	Diplopia (HP:0000651)	1.68038887
58	Abnormality of binocular vision (HP:0011514)	1.68038887
59	Genital tract atresia (HP:0001827)	1.67022677
60	EEG with generalized epileptiform discharges (HP:0011198)	1.66927992
61	Thickened helices (HP:0000391)	1.66513644
62	Abnormality of midbrain morphology (HP:0002418)	1.65646447
63	Molar tooth sign on MRI (HP:0002419)	1.65646447
64	Widely spaced teeth (HP:0000687)	1.63676826
65	Morphological abnormality of the pyramidal tract (HP:0002062)	1.60823858
66	Gait imbalance (HP:0002141)	1.60797005
67	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.60348962
68	Abnormal eating behavior (HP:0100738)	1.60320426
69	Fair hair (HP:0002286)	1.57121738
70	Impaired smooth pursuit (HP:0007772)	1.56933337
71	Anxiety (HP:0000739)	1.56560229
72	Obstructive sleep apnea (HP:0002870)	1.56553388
73	Vaginal atresia (HP:0000148)	1.55736174
74	Chronic hepatic failure (HP:0100626)	1.55496241
75	Incomplete penetrance (HP:0003829)	1.53596065
76	Abnormality of the lower motor neuron (HP:0002366)	1.50826275
77	Depression (HP:0000716)	1.50397938
78	Epiphyseal dysplasia (HP:0002656)	1.49018428
79	Alacrima (HP:0000522)	1.48480514
80	Overgrowth (HP:0001548)	1.47689915
81	Papilledema (HP:0001085)	1.47532730
82	Abnormality of ocular smooth pursuit (HP:0000617)	1.47340926
83	Decreased lacrimation (HP:0000633)	1.47144541
84	Intellectual disability, moderate (HP:0002342)	1.47118523
85	Sensory axonal neuropathy (HP:0003390)	1.46435048
86	Coronal craniosynostosis (HP:0004440)	1.46316589
87	Poor coordination (HP:0002370)	1.46108646
88	Flat cornea (HP:0007720)	1.45490426
89	Blue irides (HP:0000635)	1.45406383
90	Clonus (HP:0002169)	1.45233763
91	Hypsarrhythmia (HP:0002521)	1.44734955
92	Abnormality of the nasal septum (HP:0000419)	1.44651947
93	Cerebral hypomyelination (HP:0006808)	1.44230827
94	Striae distensae (HP:0001065)	1.43656498
95	Deeply set eye (HP:0000490)	1.43212572
96	Generalized myoclonic seizures (HP:0002123)	1.42834434
97	Papillary thyroid carcinoma (HP:0002895)	1.42543353
98	Arnold-Chiari malformation (HP:0002308)	1.41677642
99	Horizontal nystagmus (HP:0000666)	1.40957445
100	Pulmonic stenosis (HP:0001642)	1.39220739

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.26059633
2	MARK1	3.57672689
3	EPHA4	3.55397071
4	TAF1	3.43925965
5	LATS2	3.09162284
6	PINK1	2.86046933
7	NTRK3	2.85271151
8	MAP3K9	2.66060395
9	NTRK2	2.45065635
10	NTRK1	2.38732681
11	AKT3	2.25742730
12	LATS1	2.03034486
13	MAP3K4	1.78627788
14	TNIK	1.68900755
15	MINK1	1.57021965
16	SIK2	1.54738500
17	MKNK2	1.51128500
18	DYRK1A	1.41966790
19	PHKG1	1.36075870
20	PHKG2	1.36075870
21	PAK6	1.35552383
22	PRKCG	1.31257283
23	KSR1	1.30033104
24	PAK3	1.28869830
25	SGK2	1.24952269
26	MAP2K7	1.22874317
27	PLK2	1.18742580
28	MAP3K2	1.18572400
29	DAPK2	1.18234325
30	SGK494	1.14429985
31	SGK223	1.14429985
32	CAMKK1	1.12414421
33	FGFR3	1.07775901
34	GRK5	1.06255155
35	CDK5	1.03534147
36	CAMK1	1.01759255
37	UHMK1	1.01064591
38	STK38L	0.99657110
39	TYRO3	0.98655866
40	STK38	0.97678169
41	CAMK1G	0.96565315
42	SGK1	0.89949013
43	KSR2	0.85401886
44	LMTK2	0.84353414
45	CAMK2A	0.83580966
46	BMPR1B	0.81791363
47	MAPK13	0.80276493
48	WNK1	0.80118929
49	PNCK	0.79522917
50	STK11	0.79378678
51	CAMK1D	0.77669495
52	SGK3	0.75862603
53	ERBB4	0.75303907
54	MARK2	0.75242912
55	PDGFRB	0.74879293
56	OBSCN	0.73820240
57	CAMK2B	0.72957235
58	PRKCE	0.72525622
59	BCR	0.71922848
60	STK39	0.71599376
61	MAP2K4	0.69982140
62	FGFR1	0.68602340
63	CAMK4	0.67507234
64	DMPK	0.65588702
65	DYRK3	0.65382044
66	ERBB3	0.65235734
67	CAMKK2	0.64470877
68	PDGFRA	0.64323927
69	MAPK12	0.61458876
70	NUAK1	0.61291235
71	FRK	0.60310877
72	TGFBR2	0.58339813
73	CDK18	0.57361267
74	MAPKAPK5	0.55943145
75	CDK14	0.55664473
76	PTK2	0.55387659
77	CDK15	0.55345313
78	CSNK1A1L	0.54797883
79	PRKD3	0.53537528
80	RPS6KA3	0.52358322
81	MELK	0.51904403
82	CDK11A	0.51098040
83	CDK3	0.50152792
84	DYRK1B	0.49306432
85	OXSR1	0.48630973
86	PIK3CA	0.48374649
87	CSNK1G2	0.48104819
88	MAPK10	0.46497024
89	CSNK1E	0.46429478
90	PRKCH	0.45386138
91	RPS6KB1	0.40811120
92	MKNK1	0.40704160
93	PRKCZ	0.40239341
94	TGFBR1	0.39904280
95	NME1	0.39760913
96	FGFR2	0.39369066
97	CDK9	0.38586819
98	MARK3	0.38041060
99	DAPK1	0.35122023
100	PTK2B	0.35064281

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.82691438
2	Long-term potentiation_Homo sapiens_hsa04720	2.51744035
3	Glutamatergic synapse_Homo sapiens_hsa04724	2.40279900
4	Amphetamine addiction_Homo sapiens_hsa05031	2.15302693
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.15299640
6	GABAergic synapse_Homo sapiens_hsa04727	2.14750657
7	Morphine addiction_Homo sapiens_hsa05032	2.08186887
8	Circadian entrainment_Homo sapiens_hsa04713	2.07655741
9	Cocaine addiction_Homo sapiens_hsa05030	2.05257981
10	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.98729456
11	Insulin secretion_Homo sapiens_hsa04911	1.89602416
12	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.88824506
13	Dopaminergic synapse_Homo sapiens_hsa04728	1.83413353
14	Salivary secretion_Homo sapiens_hsa04970	1.75183071
15	Gastric acid secretion_Homo sapiens_hsa04971	1.66258522
16	Cholinergic synapse_Homo sapiens_hsa04725	1.60532380
17	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.59199162
18	Circadian rhythm_Homo sapiens_hsa04710	1.53659269
19	Long-term depression_Homo sapiens_hsa04730	1.52360988
20	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.49241661
21	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.46627751
22	Taste transduction_Homo sapiens_hsa04742	1.45371009
23	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.38785761
24	Olfactory transduction_Homo sapiens_hsa04740	1.36378995
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.33878757
26	Axon guidance_Homo sapiens_hsa04360	1.32998355
27	Renin secretion_Homo sapiens_hsa04924	1.32522378
28	cAMP signaling pathway_Homo sapiens_hsa04024	1.26004054
29	Melanogenesis_Homo sapiens_hsa04916	1.25820792
30	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.24581160
31	Glioma_Homo sapiens_hsa05214	1.22116513
32	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.20216278
33	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.19653383
34	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.19503811
35	ErbB signaling pathway_Homo sapiens_hsa04012	1.18934165
36	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.17640045
37	Calcium signaling pathway_Homo sapiens_hsa04020	1.17191934
38	Wnt signaling pathway_Homo sapiens_hsa04310	1.15242296
39	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.13754626
40	Estrogen signaling pathway_Homo sapiens_hsa04915	1.12579662
41	Gap junction_Homo sapiens_hsa04540	1.10487573
42	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.10256576
43	ECM-receptor interaction_Homo sapiens_hsa04512	1.08825076
44	Hippo signaling pathway_Homo sapiens_hsa04390	1.05765931
45	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.05679605
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.05437876
47	Basal cell carcinoma_Homo sapiens_hsa05217	1.05220561
48	Serotonergic synapse_Homo sapiens_hsa04726	1.02188100
49	Glucagon signaling pathway_Homo sapiens_hsa04922	1.02085369
50	Thyroid hormone synthesis_Homo sapiens_hsa04918	1.00460656
51	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.98379484
52	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.98005331
53	GnRH signaling pathway_Homo sapiens_hsa04912	0.97115538
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.92663238
55	Cardiac muscle contraction_Homo sapiens_hsa04260	0.92626970
56	Adherens junction_Homo sapiens_hsa04520	0.88003052
57	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.84958385
58	MAPK signaling pathway_Homo sapiens_hsa04010	0.84253388
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.78683426
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77242826
61	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.77219041
62	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.75100330
63	Oocyte meiosis_Homo sapiens_hsa04114	0.75061219
64	Ras signaling pathway_Homo sapiens_hsa04014	0.75052659
65	Endometrial cancer_Homo sapiens_hsa05213	0.74772462
66	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.73973983
67	Focal adhesion_Homo sapiens_hsa04510	0.72707050
68	Pancreatic secretion_Homo sapiens_hsa04972	0.71445700
69	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.68518772
70	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.66427355
71	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.65674284
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.65231691
73	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.63695235
74	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.63142664
75	Nitrogen metabolism_Homo sapiens_hsa00910	0.62503206
76	Melanoma_Homo sapiens_hsa05218	0.61929351
77	Proteoglycans in cancer_Homo sapiens_hsa05205	0.61841763
78	Rap1 signaling pathway_Homo sapiens_hsa04015	0.61094428
79	Type II diabetes mellitus_Homo sapiens_hsa04930	0.60177627
80	mTOR signaling pathway_Homo sapiens_hsa04150	0.59948272
81	FoxO signaling pathway_Homo sapiens_hsa04068	0.59824307
82	Phototransduction_Homo sapiens_hsa04744	0.59792177
83	Choline metabolism in cancer_Homo sapiens_hsa05231	0.59225411
84	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.58060519
85	AMPK signaling pathway_Homo sapiens_hsa04152	0.57744287
86	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.52739888
87	Renal cell carcinoma_Homo sapiens_hsa05211	0.49860025
88	Prion diseases_Homo sapiens_hsa05020	0.49412978
89	Mineral absorption_Homo sapiens_hsa04978	0.48730619
90	Tight junction_Homo sapiens_hsa04530	0.48584784
91	Bile secretion_Homo sapiens_hsa04976	0.48398356
92	Colorectal cancer_Homo sapiens_hsa05210	0.47999500
93	MicroRNAs in cancer_Homo sapiens_hsa05206	0.45782054
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.45380876
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40712089
96	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.40637170
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.38257190
98	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.37895247
99	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36812896
100	Prostate cancer_Homo sapiens_hsa05215	0.35654855

C16ORF52

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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