C16ORF54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.30324748
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)6.29247931
3negative regulation of cell killing (GO:0031342)6.25801356
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.25801356
5positive regulation of gamma-delta T cell activation (GO:0046645)5.84505986
6regulation of B cell receptor signaling pathway (GO:0050855)5.52850903
7negative T cell selection (GO:0043383)5.17749290
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.09150453
9antigen processing and presentation of endogenous antigen (GO:0019883)5.08312592
10cellular response to interleukin-15 (GO:0071350)5.04001088
11negative thymic T cell selection (GO:0045060)4.96836253
12response to interleukin-15 (GO:0070672)4.87934462
13positive thymic T cell selection (GO:0045059)4.55150489
14regulation of gamma-delta T cell differentiation (GO:0045586)4.51336069
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49810286
16cytidine metabolic process (GO:0046087)4.45246106
17cytidine catabolic process (GO:0006216)4.45246106
18cytidine deamination (GO:0009972)4.45246106
19regulation of gamma-delta T cell activation (GO:0046643)4.42697812
20DNA deamination (GO:0045006)4.39783157
21positive T cell selection (GO:0043368)4.32905545
22tolerance induction (GO:0002507)4.28751695
23positive regulation of B cell differentiation (GO:0045579)4.10106280
24T cell migration (GO:0072678)4.08423069
25regulation of regulatory T cell differentiation (GO:0045589)4.03656618
26regulation of B cell differentiation (GO:0045577)4.03441862
27pyrimidine ribonucleoside catabolic process (GO:0046133)4.00873302
28thymic T cell selection (GO:0045061)3.94170824
29dendritic cell chemotaxis (GO:0002407)3.91691159
30regulation of alpha-beta T cell proliferation (GO:0046640)3.90983272
31T cell selection (GO:0045058)3.87520559
32regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.86129688
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.85176116
34leukocyte aggregation (GO:0070486)3.84355646
35regulation of T cell mediated cytotoxicity (GO:0001914)3.81218527
36neutrophil activation (GO:0042119)3.80248176
37positive regulation of T cell mediated cytotoxicity (GO:0001916)3.79559317
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77887013
39immunoglobulin mediated immune response (GO:0016064)3.71467984
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.71004980
41neutrophil activation involved in immune response (GO:0002283)3.69735125
42negative regulation of T cell mediated immunity (GO:0002710)3.61998981
43negative regulation of leukocyte mediated immunity (GO:0002704)3.61275464
44activated T cell proliferation (GO:0050798)3.59033629
45mast cell activation (GO:0045576)3.58449111
46dendritic cell migration (GO:0036336)3.53906772
47regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.52192713
48regulation of natural killer cell mediated immunity (GO:0002715)3.52192713
49B cell receptor signaling pathway (GO:0050853)3.49544552
50regulation of T cell receptor signaling pathway (GO:0050856)3.47431177
51granulocyte activation (GO:0036230)3.45620124
52regulation of T cell tolerance induction (GO:0002664)3.41352432
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.38589009
54positive regulation of T cell differentiation in thymus (GO:0033089)3.38064309
55negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33980587
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.30440423
57antigen receptor-mediated signaling pathway (GO:0050851)3.30159050
58negative regulation of T cell apoptotic process (GO:0070233)3.29391352
59regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.28469559
60T cell receptor signaling pathway (GO:0050852)3.25367885
61positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.24504465
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24307487
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.24307487
64modulation by symbiont of host immune response (GO:0052553)3.24307487
65positive regulation by symbiont of host defense response (GO:0052509)3.24307487
66modulation by symbiont of host defense response (GO:0052031)3.24307487
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24307487
68Arp2/3 complex-mediated actin nucleation (GO:0034314)3.24211520
69detection of bacterium (GO:0016045)3.23625993
70detection of other organism (GO:0098543)3.22668633
71regulation of tolerance induction (GO:0002643)3.19507415
72negative regulation of interleukin-12 production (GO:0032695)3.18284118
73antigen processing and presentation via MHC class Ib (GO:0002475)3.15903334
74regulation of cell killing (GO:0031341)3.15705815
75positive regulation of granulocyte differentiation (GO:0030854)3.13095578
76leukocyte degranulation (GO:0043299)3.11785263
77positive regulation of tolerance induction (GO:0002645)3.11354007
78B cell mediated immunity (GO:0019724)3.10592167
79negative regulation of innate immune response (GO:0045824)3.08253567
80cellular extravasation (GO:0045123)3.06939248
81myeloid cell activation involved in immune response (GO:0002275)3.06286207
82negative regulation of T-helper cell differentiation (GO:0045623)3.04391612
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04391612
84mast cell activation involved in immune response (GO:0002279)3.02660124
85mast cell degranulation (GO:0043303)3.02660124
86respiratory burst (GO:0045730)3.02653050
87positive regulation of defense response to virus by host (GO:0002230)3.02417619
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99884664
89regulation of germinal center formation (GO:0002634)2.98173570
90regulation of T cell mediated immunity (GO:0002709)2.97209455
91positive regulation of cell killing (GO:0031343)2.97040594
92regulation of antigen processing and presentation (GO:0002577)2.95842303
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95801258
94interferon-gamma production (GO:0032609)2.94965214
95positive regulation of T cell mediated immunity (GO:0002711)2.89585092
96positive regulation of antigen processing and presentation (GO:0002579)2.89260741
97regulation of isotype switching to IgG isotypes (GO:0048302)2.88683983
98positive regulation of natural killer cell mediated immunity (GO:0002717)2.87292488
99actin nucleation (GO:0045010)2.85425250
100positive regulation of interleukin-8 secretion (GO:2000484)2.81360241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.59880250
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.52388671
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.13059941
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.01426056
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.02353018
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.91040105
7RUNX_20019798_ChIP-Seq_JUKART_Human3.62604494
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.31254058
9MYB_26560356_Chip-Seq_TH2_Human3.28113955
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16541378
11RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.79033090
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70081727
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64538056
14SCL_19346495_ChIP-Seq_HPC-7_Human2.51746557
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49125613
16MYB_26560356_Chip-Seq_TH1_Human2.42667868
17* SPI1_23547873_ChIP-Seq_NB4_Human2.41776749
18* GATA3_27048872_Chip-Seq_THYMUS_Human2.39478461
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.38422128
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.35731701
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.34083784
22UTX_26944678_Chip-Seq_JUKART_Human2.30693867
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25513518
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.22688966
25* GATA3_26560356_Chip-Seq_TH2_Human2.19816658
26* MAF_26560356_Chip-Seq_TH1_Human2.19146367
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03323054
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91969931
29LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.82113594
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.81127210
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77884717
32MAF_26560356_Chip-Seq_TH2_Human1.76041941
33VDR_24763502_ChIP-Seq_THP-1_Human1.73559387
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.71795825
35SPI1_23127762_ChIP-Seq_K562_Human1.71774478
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71405945
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66889355
38GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.61133716
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57706254
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45776366
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44447988
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.39754136
43VDR_24787735_ChIP-Seq_THP-1_Human1.34795977
44SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33223465
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.33129138
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33104492
47VDR_21846776_ChIP-Seq_THP-1_Human1.32867283
48BCL6_27268052_Chip-Seq_Bcells_Human1.24313194
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22409151
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21359428
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21152189
52MYC_22102868_ChIP-Seq_BL_Human1.18452633
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16997033
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11315144
55* VDR_23849224_ChIP-Seq_CD4+_Human1.10677311
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10154975
57TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09248004
58RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08992988
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07810367
60GATA1_22025678_ChIP-Seq_K562_Human1.07419297
61FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05927846
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04752490
63P300_27268052_Chip-Seq_Bcells_Human1.02434245
64CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00590878
65EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98933830
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98547614
67CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98368125
68GATA1_19941827_ChIP-Seq_MEL_Mouse0.94935854
69CIITA_25753668_ChIP-Seq_RAJI_Human0.94496124
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94439904
71GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94196437
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93085347
73* GATA3_26560356_Chip-Seq_TH1_Human0.93063886
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91895076
75SPI1_20517297_ChIP-Seq_HL60_Human0.90402814
76BCOR_27268052_Chip-Seq_Bcells_Human0.90354700
77STAT1_20625510_ChIP-Seq_HELA_Human0.90015610
78ELF1_20517297_ChIP-Seq_JURKAT_Human0.89885710
79SMRT_27268052_Chip-Seq_Bcells_Human0.88236093
80ZNF274_21170338_ChIP-Seq_K562_Hela0.88027431
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87130802
82FOXP3_21729870_ChIP-Seq_TREG_Human0.85763839
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84783890
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84757843
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84476422
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.83036626
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82265422
88NANOG_20526341_ChIP-Seq_ESCs_Human0.81486491
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81366970
90PU_27001747_Chip-Seq_BMDM_Mouse0.81323759
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80460127
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.79404232
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79403813
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77937809
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.77887471
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77641955
97VDR_22108803_ChIP-Seq_LS180_Human0.77171701
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.76873336
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.75737135
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74031144

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.52325283
2MP0005671_abnormal_response_to4.48733074
3MP0001835_abnormal_antigen_presentation3.94569440
4MP0003436_decreased_susceptibility_to3.77448589
5MP0003763_abnormal_thymus_physiology3.35271956
6MP0001800_abnormal_humoral_immune3.27843812
7MP0005000_abnormal_immune_tolerance3.25264310
8MP0009785_altered_susceptibility_to3.02750789
9MP0000685_abnormal_immune_system2.96503099
10MP0002723_abnormal_immune_serum2.90475858
11MP0005025_abnormal_response_to2.83830964
12MP0002148_abnormal_hypersensitivity_rea2.82548193
13MP0002420_abnormal_adaptive_immunity2.80597233
14MP0001819_abnormal_immune_cell2.77354578
15MP0001790_abnormal_immune_system2.73910673
16MP0005387_immune_system_phenotype2.73910673
17MP0002419_abnormal_innate_immunity2.71426380
18MP0002452_abnormal_antigen_presenting2.67066523
19MP0009333_abnormal_splenocyte_physiolog2.28936481
20MP0003866_abnormal_defecation2.26515466
21MP0002398_abnormal_bone_marrow2.24806991
22MP0002405_respiratory_system_inflammati2.16596454
23MP0000716_abnormal_immune_system2.15036905
24MP0006082_CNS_inflammation2.09517131
25MP0005464_abnormal_platelet_physiology2.05509524
26MP0010155_abnormal_intestine_physiology1.98058946
27MP0000689_abnormal_spleen_morphology1.96728992
28MP0001533_abnormal_skeleton_physiology1.94690710
29MP0000465_gastrointestinal_hemorrhage1.91599021
30MP0002722_abnormal_immune_system1.90036632
31MP0001845_abnormal_inflammatory_respons1.85125714
32MP0000703_abnormal_thymus_morphology1.84893761
33MP0002166_altered_tumor_susceptibility1.80289714
34MP0005075_abnormal_melanosome_morpholog1.74895337
35MP0002429_abnormal_blood_cell1.68274079
36MP0003303_peritoneal_inflammation1.63672842
37MP0009764_decreased_sensitivity_to1.53749984
38MP0001873_stomach_inflammation1.53385524
39MP0004947_skin_inflammation1.52749585
40MP0002396_abnormal_hematopoietic_system1.41066257
41MP0008469_abnormal_protein_level1.37443931
42MP0002132_abnormal_respiratory_system1.35962059
43MP0004381_abnormal_hair_follicle1.35856495
44MP0005310_abnormal_salivary_gland1.35553702
45MP0002138_abnormal_hepatobiliary_system1.35392093
46MP0002006_tumorigenesis1.29282830
47MP0002277_abnormal_respiratory_mucosa1.26534401
48MP0003300_gastrointestinal_ulcer1.25824812
49MP0002933_joint_inflammation1.19830316
50MP0001986_abnormal_taste_sensitivity1.14365912
51MP0003828_pulmonary_edema1.04473922
52MP0003191_abnormal_cellular_cholesterol1.00203937
53MP0009278_abnormal_bone_marrow1.00014729
54MP0002009_preneoplasia0.93198853
55MP0009763_increased_sensitivity_to0.92692532
56MP0003878_abnormal_ear_physiology0.90109243
57MP0005377_hearing/vestibular/ear_phenot0.90109243
58MP0001851_eye_inflammation0.89128115
59MP0000858_altered_metastatic_potential0.88834733
60MP0004130_abnormal_muscle_cell0.88068853
61MP0001853_heart_inflammation0.84591693
62MP0001919_abnormal_reproductive_system0.83234540
63MP0005390_skeleton_phenotype0.82857430
64MP0003172_abnormal_lysosome_physiology0.80846304
65MP0004883_abnormal_blood_vessel0.80738766
66MP0009765_abnormal_xenobiotic_induced0.79192854
67MP0001545_abnormal_hematopoietic_system0.78726971
68MP0005397_hematopoietic_system_phenotyp0.78726971
69MP0002998_abnormal_bone_remodeling0.77965229
70MP0001501_abnormal_sleep_pattern0.77627336
71MP0003448_altered_tumor_morphology0.77045781
72MP0003045_fibrosis0.75833843
73MP0003252_abnormal_bile_duct0.75663614
74MP0008872_abnormal_physiological_respon0.74932580
75MP0002019_abnormal_tumor_incidence0.73014045
76MP0005166_decreased_susceptibility_to0.72078654
77MP0002876_abnormal_thyroid_physiology0.70219247
78MP0003075_altered_response_to0.69649694
79MP0000604_amyloidosis0.69401834
80MP0008877_abnormal_DNA_methylation0.67988075
81MP0005174_abnormal_tail_pigmentation0.67672985
82MP0001663_abnormal_digestive_system0.67624235
83MP0003806_abnormal_nucleotide_metabolis0.64914870
84MP0000015_abnormal_ear_pigmentation0.63629946
85MP0000372_irregular_coat_pigmentation0.61671433
86MP0003183_abnormal_peptide_metabolism0.61281628
87MP0002693_abnormal_pancreas_physiology0.59906831
88MP0001765_abnormal_ion_homeostasis0.58644492
89MP0005084_abnormal_gallbladder_morpholo0.58045361
90MP0003195_calcinosis0.57276737
91MP0005164_abnormal_response_to0.56860692
92MP0002163_abnormal_gland_morphology0.54722586
93MP0008873_increased_physiological_sensi0.53845332
94MP0003646_muscle_fatigue0.53735416
95MP0002102_abnormal_ear_morphology0.53024046
96MP0002928_abnormal_bile_duct0.52765797
97MP0003795_abnormal_bone_structure0.52583774
98MP0005319_abnormal_enzyme/_coenzyme0.50976193
99MP0000249_abnormal_blood_vessel0.50868831
100MP0003011_delayed_dark_adaptation0.50025455

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.49679538
2Elevated erythrocyte sedimentation rate (HP:0003565)5.38267374
3Myositis (HP:0100614)5.20834398
4T lymphocytopenia (HP:0005403)4.85219070
5Eczematoid dermatitis (HP:0000976)4.78404246
6Abnormality of T cell number (HP:0011839)4.77891147
7IgG deficiency (HP:0004315)4.59763028
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.54299149
9Optic neuritis (HP:0100653)4.43316583
10Retrobulbar optic neuritis (HP:0100654)4.43316583
11Orchitis (HP:0100796)4.40128937
12Abnormality of T cells (HP:0002843)4.19063095
13Recurrent abscess formation (HP:0002722)4.17547250
14Recurrent bacterial skin infections (HP:0005406)4.15967034
15Recurrent fungal infections (HP:0002841)4.11140787
16Severe combined immunodeficiency (HP:0004430)4.06380092
17Meningitis (HP:0001287)3.91368175
18Panhypogammaglobulinemia (HP:0003139)3.83504693
19Encephalitis (HP:0002383)3.78730330
20Recurrent cutaneous fungal infections (HP:0011370)3.70943878
21Chronic mucocutaneous candidiasis (HP:0002728)3.70943878
22Abnormality of macrophages (HP:0004311)3.68603559
23Autoimmune hemolytic anemia (HP:0001890)3.59853977
24Gastrointestinal infarctions (HP:0005244)3.57001093
25Abnormality of T cell physiology (HP:0011840)3.50736884
26Abnormality of eosinophils (HP:0001879)3.50636612
27Obstructive lung disease (HP:0006536)3.44609769
28Chronic obstructive pulmonary disease (HP:0006510)3.44609769
29Stomach cancer (HP:0012126)3.43841075
30Leukocytosis (HP:0001974)3.42146725
31Mediastinal lymphadenopathy (HP:0100721)3.41972415
32Agammaglobulinemia (HP:0004432)3.40476056
33Increased IgM level (HP:0003496)3.37014588
34Granulocytopenia (HP:0001913)3.35643879
35Eosinophilia (HP:0001880)3.33419085
36Pustule (HP:0200039)3.31505822
37Recurrent skin infections (HP:0001581)3.29242627
38Abnormality of the prostate (HP:0008775)3.28063184
39Vasculitis (HP:0002633)3.22925536
40Pulmonary infiltrates (HP:0002113)3.19881512
41Combined immunodeficiency (HP:0005387)3.10448753
42Abnormality of B cell number (HP:0010975)3.10324433
43Keratoconjunctivitis (HP:0001096)3.08193957
44Keratoconjunctivitis sicca (HP:0001097)3.08047740
45Chest pain (HP:0100749)3.04767911
46Thyroiditis (HP:0100646)3.01565670
47IgM deficiency (HP:0002850)2.92130726
48Hemoptysis (HP:0002105)2.89720225
49Recurrent viral infections (HP:0004429)2.89508405
50Recurrent gram-negative bacterial infections (HP:0005420)2.88596527
51Recurrent bronchitis (HP:0002837)2.75195531
52Prostate neoplasm (HP:0100787)2.72843546
53Increased IgE level (HP:0003212)2.71488643
54Prolonged bleeding time (HP:0003010)2.68502927
55Hypochromic anemia (HP:0001931)2.65082296
56Arterial thrombosis (HP:0004420)2.64469204
57Autoimmune thrombocytopenia (HP:0001973)2.61190157
58B lymphocytopenia (HP:0010976)2.56393723
59Chronic diarrhea (HP:0002028)2.54164733
60Hypochromic microcytic anemia (HP:0004840)2.49017154
61Pulmonary embolism (HP:0002204)2.47062121
62Lymphopenia (HP:0001888)2.46900323
63Urticaria (HP:0001025)2.46709217
64Anorexia (HP:0002039)2.44202463
65Gangrene (HP:0100758)2.43052156
66Abnormality of the pleura (HP:0002103)2.42561706
67Hypoproteinemia (HP:0003075)2.42170054
68Joint swelling (HP:0001386)2.42159841
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.36921845
70Epistaxis (HP:0000421)2.35323436
71Episodic fever (HP:0001954)2.33310173
72Hypergammaglobulinemia (HP:0010702)2.32481537
73Spontaneous hematomas (HP:0007420)2.20663291
74Absent rod-and cone-mediated responses on ERG (HP:0007688)2.17580553
75Chronic otitis media (HP:0000389)2.15780539
76Inflammation of the large intestine (HP:0002037)2.15355681
77Gingival bleeding (HP:0000225)2.14486977
78Petechiae (HP:0000967)2.08501374
79Sepsis (HP:0100806)2.07656484
80Verrucae (HP:0200043)2.07545345
81Papilloma (HP:0012740)2.07545345
82Gastrointestinal inflammation (HP:0004386)2.05910348
83Pulmonary fibrosis (HP:0002206)2.03477778
84Keratitis (HP:0000491)2.02222119
85Abnormality of male internal genitalia (HP:0000022)2.00710014
86Glomerulopathy (HP:0100820)2.00324910
87Skin rash (HP:0000988)1.99960020
88Aplastic anemia (HP:0001915)1.97022789
89Premature loss of primary teeth (HP:0006323)1.93478620
90Alveolar cell carcinoma (HP:0006519)1.93299553
91Lymphoma (HP:0002665)1.90287483
92Congenital stationary night blindness (HP:0007642)1.89473150
93Gingivitis (HP:0000230)1.89456239
94Cellulitis (HP:0100658)1.88554653
95Vertigo (HP:0002321)1.84746098
96Neutropenia (HP:0001875)1.84674159
97Abnormality of the pericardium (HP:0001697)1.83429873
98Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81731760
99Polyneuropathy (HP:0001271)1.80632981
100Abnormal rod and cone electroretinograms (HP:0008323)1.80240943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.74721292
2TAOK34.43295153
3MAP4K14.16899004
4RIPK43.56651521
5GRK63.33168093
6FES3.13507400
7ITK2.23335646
8KDR2.20876036
9SYK2.20788611
10TNK22.13377779
11IRAK42.12538212
12CSK2.08787253
13ZAP702.08290907
14BTK2.07892103
15TESK21.97586529
16BLK1.90390957
17IKBKE1.87709511
18KIT1.84676930
19JAK31.78714876
20TEC1.73329454
21MAP2K21.73130710
22MAP3K141.67507372
23LCK1.66997031
24TYK21.62151968
25TBK11.58289909
26HCK1.55457964
27IKBKB1.54924950
28LYN1.50925717
29TLK11.50784165
30ADRBK21.46734915
31FRK1.46414635
32MAP3K131.36215827
33ERN11.27676333
34BMPR21.26911882
35CSF1R1.26156083
36NUAK11.24475376
37MAP2K31.23967750
38PRKCQ1.14567378
39BCKDK1.14376377
40GRK71.11384018
41JAK11.09355587
42JAK20.97529469
43MAP3K110.95894411
44PIM10.95403405
45ZAK0.95051026
46MATK0.95043148
47PIK3CG0.86123068
48MARK30.79449961
49GRK10.66211582
50MUSK0.65202848
51CAMKK20.64034485
52FYN0.60998139
53SIK30.60840466
54FGR0.59834928
55PIK3CA0.59424187
56EPHB10.57572847
57MAP2K60.57438627
58STK100.57079705
59CAMKK10.56318038
60PDK10.56038152
61MAP3K70.55945175
62MAPK70.54410883
63PINK10.53033672
64ACVR1B0.49965930
65MAP4K20.48162310
66MAP3K30.47911840
67SIK20.46097034
68PASK0.46006021
69TRPM70.45700569
70TAOK10.43674623
71IRAK10.43480769
72PTK2B0.43285410
73DAPK20.43015439
74ADRBK10.41787740
75ABL10.41452377
76RPS6KA60.41189476
77MAPKAPK30.39564839
78MAP3K10.38776014
79IGF1R0.38133489
80PRKD20.35424981
81MAPK120.35180137
82NLK0.34838617
83MST40.32878540
84PRKCD0.32416188
85VRK20.31936100
86MAPKAPK20.31845809
87RPS6KL10.31668658
88RPS6KC10.31668658
89CDK80.31637981
90MAPK110.31458786
91GRK50.29484936
92HIPK20.29190471
93MAPK30.28452159
94MAPK130.27289095
95PRKCH0.27249388
96TGFBR20.26713165
97CDK40.26086918
98SCYL20.26008263
99STK110.25592338
100MAP2K10.25434122

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.93018768
2Graft-versus-host disease_Homo sapiens_hsa053323.62165894
3Allograft rejection_Homo sapiens_hsa053303.51528626
4Autoimmune thyroid disease_Homo sapiens_hsa053203.46470359
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.88152141
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.77116167
7Type I diabetes mellitus_Homo sapiens_hsa049402.64498330
8T cell receptor signaling pathway_Homo sapiens_hsa046602.56520238
9Antigen processing and presentation_Homo sapiens_hsa046122.55316477
10Leishmaniasis_Homo sapiens_hsa051402.51171409
11Hematopoietic cell lineage_Homo sapiens_hsa046402.44453692
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.38680358
13Asthma_Homo sapiens_hsa053102.30009122
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.25275114
15Osteoclast differentiation_Homo sapiens_hsa043802.20521512
16Staphylococcus aureus infection_Homo sapiens_hsa051502.16569962
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.11908249
18B cell receptor signaling pathway_Homo sapiens_hsa046621.95768909
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90255659
20Measles_Homo sapiens_hsa051621.90240348
21Viral myocarditis_Homo sapiens_hsa054161.64696157
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64479923
23Rheumatoid arthritis_Homo sapiens_hsa053231.56430031
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54907976
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51706094
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46024006
27Malaria_Homo sapiens_hsa051441.45807309
28Tuberculosis_Homo sapiens_hsa051521.42269282
29Chemokine signaling pathway_Homo sapiens_hsa040621.41203153
30Herpes simplex infection_Homo sapiens_hsa051681.35461961
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.33717904
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22799174
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21307211
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.08071538
35TNF signaling pathway_Homo sapiens_hsa046681.06827321
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03285865
37Toxoplasmosis_Homo sapiens_hsa051451.02230531
38Platelet activation_Homo sapiens_hsa046110.99193360
39Influenza A_Homo sapiens_hsa051640.98603189
40African trypanosomiasis_Homo sapiens_hsa051430.94595055
41Acute myeloid leukemia_Homo sapiens_hsa052210.88551698
42Legionellosis_Homo sapiens_hsa051340.85143127
43Shigellosis_Homo sapiens_hsa051310.84176496
44Arachidonic acid metabolism_Homo sapiens_hsa005900.76961784
45Phototransduction_Homo sapiens_hsa047440.75088250
46Apoptosis_Homo sapiens_hsa042100.74163143
47Pertussis_Homo sapiens_hsa051330.71633934
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71055033
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69194371
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68691118
51Linoleic acid metabolism_Homo sapiens_hsa005910.67900024
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65736968
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.64378143
54Epstein-Barr virus infection_Homo sapiens_hsa051690.63261391
55Phagosome_Homo sapiens_hsa041450.62290607
56Salmonella infection_Homo sapiens_hsa051320.61344613
57Hepatitis B_Homo sapiens_hsa051610.56383299
58Nitrogen metabolism_Homo sapiens_hsa009100.54279211
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51765396
60Regulation of autophagy_Homo sapiens_hsa041400.49444860
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48252257
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47861431
63Non-small cell lung cancer_Homo sapiens_hsa052230.46501770
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46095095
65Hepatitis C_Homo sapiens_hsa051600.45698636
66HTLV-I infection_Homo sapiens_hsa051660.43861420
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39024700
68Systemic lupus erythematosus_Homo sapiens_hsa053220.38952681
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.38634090
70Ether lipid metabolism_Homo sapiens_hsa005650.38234452
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36742060
72Olfactory transduction_Homo sapiens_hsa047400.33311911
73Endocytosis_Homo sapiens_hsa041440.33156850
74Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30608428
75Homologous recombination_Homo sapiens_hsa034400.30313077
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29609557
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.29124384
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.28753602
79Viral carcinogenesis_Homo sapiens_hsa052030.28461709
80Caffeine metabolism_Homo sapiens_hsa002320.28125838
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27420419
82MAPK signaling pathway_Homo sapiens_hsa040100.26837946
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.26618343
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.26522011
85Morphine addiction_Homo sapiens_hsa050320.25354633
86VEGF signaling pathway_Homo sapiens_hsa043700.24170359
87Lysosome_Homo sapiens_hsa041420.24135989
88Other glycan degradation_Homo sapiens_hsa005110.23923473
89Prolactin signaling pathway_Homo sapiens_hsa049170.23608273
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23323390
91Proteasome_Homo sapiens_hsa030500.19411469
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19289236
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18688261
94RNA degradation_Homo sapiens_hsa030180.16901022
95Collecting duct acid secretion_Homo sapiens_hsa049660.15964274
96ABC transporters_Homo sapiens_hsa020100.14138927
97RNA polymerase_Homo sapiens_hsa030200.13313312
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.11791550
99Dorso-ventral axis formation_Homo sapiens_hsa043200.11152696
100Peroxisome_Homo sapiens_hsa041460.10718062

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