Rank | Gene Set | Z-score |
---|---|---|
1 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G | 6.30324748 |
2 | positive regulation of antigen receptor-mediated signaling pathway (GO:0050857) | 6.29247931 |
3 | negative regulation of cell killing (GO:0031342) | 6.25801356 |
4 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 6.25801356 |
5 | positive regulation of gamma-delta T cell activation (GO:0046645) | 5.84505986 |
6 | regulation of B cell receptor signaling pathway (GO:0050855) | 5.52850903 |
7 | negative T cell selection (GO:0043383) | 5.17749290 |
8 | antigen processing and presentation of endogenous peptide antigen (GO:0002483) | 5.09150453 |
9 | antigen processing and presentation of endogenous antigen (GO:0019883) | 5.08312592 |
10 | cellular response to interleukin-15 (GO:0071350) | 5.04001088 |
11 | negative thymic T cell selection (GO:0045060) | 4.96836253 |
12 | response to interleukin-15 (GO:0070672) | 4.87934462 |
13 | positive thymic T cell selection (GO:0045059) | 4.55150489 |
14 | regulation of gamma-delta T cell differentiation (GO:0045586) | 4.51336069 |
15 | antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885) | 4.49810286 |
16 | cytidine metabolic process (GO:0046087) | 4.45246106 |
17 | cytidine catabolic process (GO:0006216) | 4.45246106 |
18 | cytidine deamination (GO:0009972) | 4.45246106 |
19 | regulation of gamma-delta T cell activation (GO:0046643) | 4.42697812 |
20 | DNA deamination (GO:0045006) | 4.39783157 |
21 | positive T cell selection (GO:0043368) | 4.32905545 |
22 | tolerance induction (GO:0002507) | 4.28751695 |
23 | positive regulation of B cell differentiation (GO:0045579) | 4.10106280 |
24 | T cell migration (GO:0072678) | 4.08423069 |
25 | regulation of regulatory T cell differentiation (GO:0045589) | 4.03656618 |
26 | regulation of B cell differentiation (GO:0045577) | 4.03441862 |
27 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.00873302 |
28 | thymic T cell selection (GO:0045061) | 3.94170824 |
29 | dendritic cell chemotaxis (GO:0002407) | 3.91691159 |
30 | regulation of alpha-beta T cell proliferation (GO:0046640) | 3.90983272 |
31 | T cell selection (GO:0045058) | 3.87520559 |
32 | regulation of antigen receptor-mediated signaling pathway (GO:0050854) | 3.86129688 |
33 | negative regulation of lymphocyte mediated immunity (GO:0002707) | 3.85176116 |
34 | leukocyte aggregation (GO:0070486) | 3.84355646 |
35 | regulation of T cell mediated cytotoxicity (GO:0001914) | 3.81218527 |
36 | neutrophil activation (GO:0042119) | 3.80248176 |
37 | positive regulation of T cell mediated cytotoxicity (GO:0001916) | 3.79559317 |
38 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.77887013 |
39 | immunoglobulin mediated immune response (GO:0016064) | 3.71467984 |
40 | positive regulation of alpha-beta T cell proliferation (GO:0046641) | 3.71004980 |
41 | neutrophil activation involved in immune response (GO:0002283) | 3.69735125 |
42 | negative regulation of T cell mediated immunity (GO:0002710) | 3.61998981 |
43 | negative regulation of leukocyte mediated immunity (GO:0002704) | 3.61275464 |
44 | activated T cell proliferation (GO:0050798) | 3.59033629 |
45 | mast cell activation (GO:0045576) | 3.58449111 |
46 | dendritic cell migration (GO:0036336) | 3.53906772 |
47 | regulation of natural killer cell mediated cytotoxicity (GO:0042269) | 3.52192713 |
48 | regulation of natural killer cell mediated immunity (GO:0002715) | 3.52192713 |
49 | B cell receptor signaling pathway (GO:0050853) | 3.49544552 |
50 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.47431177 |
51 | granulocyte activation (GO:0036230) | 3.45620124 |
52 | regulation of T cell tolerance induction (GO:0002664) | 3.41352432 |
53 | regulation of leukocyte mediated cytotoxicity (GO:0001910) | 3.38589009 |
54 | positive regulation of T cell differentiation in thymus (GO:0033089) | 3.38064309 |
55 | negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515) | 3.33980587 |
56 | positive regulation of leukocyte mediated cytotoxicity (GO:0001912) | 3.30440423 |
57 | antigen receptor-mediated signaling pathway (GO:0050851) | 3.30159050 |
58 | negative regulation of T cell apoptotic process (GO:0070233) | 3.29391352 |
59 | regulation of antigen processing and presentation of peptide antigen (GO:0002583) | 3.28469559 |
60 | T cell receptor signaling pathway (GO:0050852) | 3.25367885 |
61 | positive regulation of interleukin-2 biosynthetic process (GO:0045086) | 3.24504465 |
62 | modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0 | 3.24307487 |
63 | positive regulation by organism of defense response of other organism involved in symbiotic interact | 3.24307487 |
64 | modulation by symbiont of host immune response (GO:0052553) | 3.24307487 |
65 | positive regulation by symbiont of host defense response (GO:0052509) | 3.24307487 |
66 | modulation by symbiont of host defense response (GO:0052031) | 3.24307487 |
67 | modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00 | 3.24307487 |
68 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 3.24211520 |
69 | detection of bacterium (GO:0016045) | 3.23625993 |
70 | detection of other organism (GO:0098543) | 3.22668633 |
71 | regulation of tolerance induction (GO:0002643) | 3.19507415 |
72 | negative regulation of interleukin-12 production (GO:0032695) | 3.18284118 |
73 | antigen processing and presentation via MHC class Ib (GO:0002475) | 3.15903334 |
74 | regulation of cell killing (GO:0031341) | 3.15705815 |
75 | positive regulation of granulocyte differentiation (GO:0030854) | 3.13095578 |
76 | leukocyte degranulation (GO:0043299) | 3.11785263 |
77 | positive regulation of tolerance induction (GO:0002645) | 3.11354007 |
78 | B cell mediated immunity (GO:0019724) | 3.10592167 |
79 | negative regulation of innate immune response (GO:0045824) | 3.08253567 |
80 | cellular extravasation (GO:0045123) | 3.06939248 |
81 | myeloid cell activation involved in immune response (GO:0002275) | 3.06286207 |
82 | negative regulation of T-helper cell differentiation (GO:0045623) | 3.04391612 |
83 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 3.04391612 |
84 | mast cell activation involved in immune response (GO:0002279) | 3.02660124 |
85 | mast cell degranulation (GO:0043303) | 3.02660124 |
86 | respiratory burst (GO:0045730) | 3.02653050 |
87 | positive regulation of defense response to virus by host (GO:0002230) | 3.02417619 |
88 | regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923) | 2.99884664 |
89 | regulation of germinal center formation (GO:0002634) | 2.98173570 |
90 | regulation of T cell mediated immunity (GO:0002709) | 2.97209455 |
91 | positive regulation of cell killing (GO:0031343) | 2.97040594 |
92 | regulation of antigen processing and presentation (GO:0002577) | 2.95842303 |
93 | negative regulation of adaptive immune response based on somatic recombination of immune receptors b | 2.95801258 |
94 | interferon-gamma production (GO:0032609) | 2.94965214 |
95 | positive regulation of T cell mediated immunity (GO:0002711) | 2.89585092 |
96 | positive regulation of antigen processing and presentation (GO:0002579) | 2.89260741 |
97 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.88683983 |
98 | positive regulation of natural killer cell mediated immunity (GO:0002717) | 2.87292488 |
99 | actin nucleation (GO:0045010) | 2.85425250 |
100 | positive regulation of interleukin-8 secretion (GO:2000484) | 2.81360241 |
Rank | Gene Set | Z-score |
---|---|---|
1 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 6.59880250 |
2 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 5.52388671 |
3 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 5.13059941 |
4 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 5.01426056 |
5 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 4.02353018 |
6 | IRF8_21731497_ChIP-ChIP_J774_Mouse | 3.91040105 |
7 | RUNX_20019798_ChIP-Seq_JUKART_Human | 3.62604494 |
8 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 3.31254058 |
9 | MYB_26560356_Chip-Seq_TH2_Human | 3.28113955 |
10 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 3.16541378 |
11 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 2.79033090 |
12 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 2.70081727 |
13 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 2.64538056 |
14 | SCL_19346495_ChIP-Seq_HPC-7_Human | 2.51746557 |
15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.49125613 |
16 | MYB_26560356_Chip-Seq_TH1_Human | 2.42667868 |
17 | * SPI1_23547873_ChIP-Seq_NB4_Human | 2.41776749 |
18 | * GATA3_27048872_Chip-Seq_THYMUS_Human | 2.39478461 |
19 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 2.38422128 |
20 | FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse | 2.35731701 |
21 | IRF8_27001747_Chip-Seq_BMDM_Mouse | 2.34083784 |
22 | UTX_26944678_Chip-Seq_JUKART_Human | 2.30693867 |
23 | SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse | 2.25513518 |
24 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 2.22688966 |
25 | * GATA3_26560356_Chip-Seq_TH2_Human | 2.19816658 |
26 | * MAF_26560356_Chip-Seq_TH1_Human | 2.19146367 |
27 | E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human | 2.03323054 |
28 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.91969931 |
29 | LMO2_20887958_ChIP-Seq_HPC-7_Mouse | 1.82113594 |
30 | RUNX1_22412390_ChIP-Seq_EML_Mouse | 1.81127210 |
31 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.77884717 |
32 | MAF_26560356_Chip-Seq_TH2_Human | 1.76041941 |
33 | VDR_24763502_ChIP-Seq_THP-1_Human | 1.73559387 |
34 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.71795825 |
35 | SPI1_23127762_ChIP-Seq_K562_Human | 1.71774478 |
36 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.71405945 |
37 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.66889355 |
38 | GATA2_20887958_ChIP-Seq_HPC-7_Mouse | 1.61133716 |
39 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.57706254 |
40 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 1.45776366 |
41 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.44447988 |
42 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.39754136 |
43 | VDR_24787735_ChIP-Seq_THP-1_Human | 1.34795977 |
44 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.33223465 |
45 | VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human | 1.33129138 |
46 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.33104492 |
47 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.32867283 |
48 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.24313194 |
49 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.22409151 |
50 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 1.21359428 |
51 | PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.21152189 |
52 | MYC_22102868_ChIP-Seq_BL_Human | 1.18452633 |
53 | PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 1.16997033 |
54 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11315144 |
55 | * VDR_23849224_ChIP-Seq_CD4+_Human | 1.10677311 |
56 | CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse | 1.10154975 |
57 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.09248004 |
58 | RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.08992988 |
59 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.07810367 |
60 | GATA1_22025678_ChIP-Seq_K562_Human | 1.07419297 |
61 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.05927846 |
62 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.04752490 |
63 | P300_27268052_Chip-Seq_Bcells_Human | 1.02434245 |
64 | CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse | 1.00590878 |
65 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.98933830 |
66 | SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.98547614 |
67 | CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.98368125 |
68 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.94935854 |
69 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.94496124 |
70 | PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse | 0.94439904 |
71 | GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.94196437 |
72 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 0.93085347 |
73 | * GATA3_26560356_Chip-Seq_TH1_Human | 0.93063886 |
74 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.91895076 |
75 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.90402814 |
76 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.90354700 |
77 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.90015610 |
78 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.89885710 |
79 | SMRT_27268052_Chip-Seq_Bcells_Human | 0.88236093 |
80 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.88027431 |
81 | CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87130802 |
82 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.85763839 |
83 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.84783890 |
84 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.84757843 |
85 | GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.84476422 |
86 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.83036626 |
87 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.82265422 |
88 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.81486491 |
89 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 0.81366970 |
90 | PU_27001747_Chip-Seq_BMDM_Mouse | 0.81323759 |
91 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.80460127 |
92 | PU.1_20513432_ChIP-Seq_Bcells_Mouse | 0.79404232 |
93 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.79403813 |
94 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.77937809 |
95 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 0.77887471 |
96 | TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.77641955 |
97 | VDR_22108803_ChIP-Seq_LS180_Human | 0.77171701 |
98 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 0.76873336 |
99 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.75737135 |
100 | TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 0.74031144 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003724_increased_susceptibility_to | 4.52325283 |
2 | MP0005671_abnormal_response_to | 4.48733074 |
3 | MP0001835_abnormal_antigen_presentation | 3.94569440 |
4 | MP0003436_decreased_susceptibility_to | 3.77448589 |
5 | MP0003763_abnormal_thymus_physiology | 3.35271956 |
6 | MP0001800_abnormal_humoral_immune | 3.27843812 |
7 | MP0005000_abnormal_immune_tolerance | 3.25264310 |
8 | MP0009785_altered_susceptibility_to | 3.02750789 |
9 | MP0000685_abnormal_immune_system | 2.96503099 |
10 | MP0002723_abnormal_immune_serum | 2.90475858 |
11 | MP0005025_abnormal_response_to | 2.83830964 |
12 | MP0002148_abnormal_hypersensitivity_rea | 2.82548193 |
13 | MP0002420_abnormal_adaptive_immunity | 2.80597233 |
14 | MP0001819_abnormal_immune_cell | 2.77354578 |
15 | MP0001790_abnormal_immune_system | 2.73910673 |
16 | MP0005387_immune_system_phenotype | 2.73910673 |
17 | MP0002419_abnormal_innate_immunity | 2.71426380 |
18 | MP0002452_abnormal_antigen_presenting | 2.67066523 |
19 | MP0009333_abnormal_splenocyte_physiolog | 2.28936481 |
20 | MP0003866_abnormal_defecation | 2.26515466 |
21 | MP0002398_abnormal_bone_marrow | 2.24806991 |
22 | MP0002405_respiratory_system_inflammati | 2.16596454 |
23 | MP0000716_abnormal_immune_system | 2.15036905 |
24 | MP0006082_CNS_inflammation | 2.09517131 |
25 | MP0005464_abnormal_platelet_physiology | 2.05509524 |
26 | MP0010155_abnormal_intestine_physiology | 1.98058946 |
27 | MP0000689_abnormal_spleen_morphology | 1.96728992 |
28 | MP0001533_abnormal_skeleton_physiology | 1.94690710 |
29 | MP0000465_gastrointestinal_hemorrhage | 1.91599021 |
30 | MP0002722_abnormal_immune_system | 1.90036632 |
31 | MP0001845_abnormal_inflammatory_respons | 1.85125714 |
32 | MP0000703_abnormal_thymus_morphology | 1.84893761 |
33 | MP0002166_altered_tumor_susceptibility | 1.80289714 |
34 | MP0005075_abnormal_melanosome_morpholog | 1.74895337 |
35 | MP0002429_abnormal_blood_cell | 1.68274079 |
36 | MP0003303_peritoneal_inflammation | 1.63672842 |
37 | MP0009764_decreased_sensitivity_to | 1.53749984 |
38 | MP0001873_stomach_inflammation | 1.53385524 |
39 | MP0004947_skin_inflammation | 1.52749585 |
40 | MP0002396_abnormal_hematopoietic_system | 1.41066257 |
41 | MP0008469_abnormal_protein_level | 1.37443931 |
42 | MP0002132_abnormal_respiratory_system | 1.35962059 |
43 | MP0004381_abnormal_hair_follicle | 1.35856495 |
44 | MP0005310_abnormal_salivary_gland | 1.35553702 |
45 | MP0002138_abnormal_hepatobiliary_system | 1.35392093 |
46 | MP0002006_tumorigenesis | 1.29282830 |
47 | MP0002277_abnormal_respiratory_mucosa | 1.26534401 |
48 | MP0003300_gastrointestinal_ulcer | 1.25824812 |
49 | MP0002933_joint_inflammation | 1.19830316 |
50 | MP0001986_abnormal_taste_sensitivity | 1.14365912 |
51 | MP0003828_pulmonary_edema | 1.04473922 |
52 | MP0003191_abnormal_cellular_cholesterol | 1.00203937 |
53 | MP0009278_abnormal_bone_marrow | 1.00014729 |
54 | MP0002009_preneoplasia | 0.93198853 |
55 | MP0009763_increased_sensitivity_to | 0.92692532 |
56 | MP0003878_abnormal_ear_physiology | 0.90109243 |
57 | MP0005377_hearing/vestibular/ear_phenot | 0.90109243 |
58 | MP0001851_eye_inflammation | 0.89128115 |
59 | MP0000858_altered_metastatic_potential | 0.88834733 |
60 | MP0004130_abnormal_muscle_cell | 0.88068853 |
61 | MP0001853_heart_inflammation | 0.84591693 |
62 | MP0001919_abnormal_reproductive_system | 0.83234540 |
63 | MP0005390_skeleton_phenotype | 0.82857430 |
64 | MP0003172_abnormal_lysosome_physiology | 0.80846304 |
65 | MP0004883_abnormal_blood_vessel | 0.80738766 |
66 | MP0009765_abnormal_xenobiotic_induced | 0.79192854 |
67 | MP0001545_abnormal_hematopoietic_system | 0.78726971 |
68 | MP0005397_hematopoietic_system_phenotyp | 0.78726971 |
69 | MP0002998_abnormal_bone_remodeling | 0.77965229 |
70 | MP0001501_abnormal_sleep_pattern | 0.77627336 |
71 | MP0003448_altered_tumor_morphology | 0.77045781 |
72 | MP0003045_fibrosis | 0.75833843 |
73 | MP0003252_abnormal_bile_duct | 0.75663614 |
74 | MP0008872_abnormal_physiological_respon | 0.74932580 |
75 | MP0002019_abnormal_tumor_incidence | 0.73014045 |
76 | MP0005166_decreased_susceptibility_to | 0.72078654 |
77 | MP0002876_abnormal_thyroid_physiology | 0.70219247 |
78 | MP0003075_altered_response_to | 0.69649694 |
79 | MP0000604_amyloidosis | 0.69401834 |
80 | MP0008877_abnormal_DNA_methylation | 0.67988075 |
81 | MP0005174_abnormal_tail_pigmentation | 0.67672985 |
82 | MP0001663_abnormal_digestive_system | 0.67624235 |
83 | MP0003806_abnormal_nucleotide_metabolis | 0.64914870 |
84 | MP0000015_abnormal_ear_pigmentation | 0.63629946 |
85 | MP0000372_irregular_coat_pigmentation | 0.61671433 |
86 | MP0003183_abnormal_peptide_metabolism | 0.61281628 |
87 | MP0002693_abnormal_pancreas_physiology | 0.59906831 |
88 | MP0001765_abnormal_ion_homeostasis | 0.58644492 |
89 | MP0005084_abnormal_gallbladder_morpholo | 0.58045361 |
90 | MP0003195_calcinosis | 0.57276737 |
91 | MP0005164_abnormal_response_to | 0.56860692 |
92 | MP0002163_abnormal_gland_morphology | 0.54722586 |
93 | MP0008873_increased_physiological_sensi | 0.53845332 |
94 | MP0003646_muscle_fatigue | 0.53735416 |
95 | MP0002102_abnormal_ear_morphology | 0.53024046 |
96 | MP0002928_abnormal_bile_duct | 0.52765797 |
97 | MP0003795_abnormal_bone_structure | 0.52583774 |
98 | MP0005319_abnormal_enzyme/_coenzyme | 0.50976193 |
99 | MP0000249_abnormal_blood_vessel | 0.50868831 |
100 | MP0003011_delayed_dark_adaptation | 0.50025455 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Stomatitis (HP:0010280) | 5.49679538 |
2 | Elevated erythrocyte sedimentation rate (HP:0003565) | 5.38267374 |
3 | Myositis (HP:0100614) | 5.20834398 |
4 | T lymphocytopenia (HP:0005403) | 4.85219070 |
5 | Eczematoid dermatitis (HP:0000976) | 4.78404246 |
6 | Abnormality of T cell number (HP:0011839) | 4.77891147 |
7 | IgG deficiency (HP:0004315) | 4.59763028 |
8 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 4.54299149 |
9 | Optic neuritis (HP:0100653) | 4.43316583 |
10 | Retrobulbar optic neuritis (HP:0100654) | 4.43316583 |
11 | Orchitis (HP:0100796) | 4.40128937 |
12 | Abnormality of T cells (HP:0002843) | 4.19063095 |
13 | Recurrent abscess formation (HP:0002722) | 4.17547250 |
14 | Recurrent bacterial skin infections (HP:0005406) | 4.15967034 |
15 | Recurrent fungal infections (HP:0002841) | 4.11140787 |
16 | Severe combined immunodeficiency (HP:0004430) | 4.06380092 |
17 | Meningitis (HP:0001287) | 3.91368175 |
18 | Panhypogammaglobulinemia (HP:0003139) | 3.83504693 |
19 | Encephalitis (HP:0002383) | 3.78730330 |
20 | Recurrent cutaneous fungal infections (HP:0011370) | 3.70943878 |
21 | Chronic mucocutaneous candidiasis (HP:0002728) | 3.70943878 |
22 | Abnormality of macrophages (HP:0004311) | 3.68603559 |
23 | Autoimmune hemolytic anemia (HP:0001890) | 3.59853977 |
24 | Gastrointestinal infarctions (HP:0005244) | 3.57001093 |
25 | Abnormality of T cell physiology (HP:0011840) | 3.50736884 |
26 | Abnormality of eosinophils (HP:0001879) | 3.50636612 |
27 | Obstructive lung disease (HP:0006536) | 3.44609769 |
28 | Chronic obstructive pulmonary disease (HP:0006510) | 3.44609769 |
29 | Stomach cancer (HP:0012126) | 3.43841075 |
30 | Leukocytosis (HP:0001974) | 3.42146725 |
31 | Mediastinal lymphadenopathy (HP:0100721) | 3.41972415 |
32 | Agammaglobulinemia (HP:0004432) | 3.40476056 |
33 | Increased IgM level (HP:0003496) | 3.37014588 |
34 | Granulocytopenia (HP:0001913) | 3.35643879 |
35 | Eosinophilia (HP:0001880) | 3.33419085 |
36 | Pustule (HP:0200039) | 3.31505822 |
37 | Recurrent skin infections (HP:0001581) | 3.29242627 |
38 | Abnormality of the prostate (HP:0008775) | 3.28063184 |
39 | Vasculitis (HP:0002633) | 3.22925536 |
40 | Pulmonary infiltrates (HP:0002113) | 3.19881512 |
41 | Combined immunodeficiency (HP:0005387) | 3.10448753 |
42 | Abnormality of B cell number (HP:0010975) | 3.10324433 |
43 | Keratoconjunctivitis (HP:0001096) | 3.08193957 |
44 | Keratoconjunctivitis sicca (HP:0001097) | 3.08047740 |
45 | Chest pain (HP:0100749) | 3.04767911 |
46 | Thyroiditis (HP:0100646) | 3.01565670 |
47 | IgM deficiency (HP:0002850) | 2.92130726 |
48 | Hemoptysis (HP:0002105) | 2.89720225 |
49 | Recurrent viral infections (HP:0004429) | 2.89508405 |
50 | Recurrent gram-negative bacterial infections (HP:0005420) | 2.88596527 |
51 | Recurrent bronchitis (HP:0002837) | 2.75195531 |
52 | Prostate neoplasm (HP:0100787) | 2.72843546 |
53 | Increased IgE level (HP:0003212) | 2.71488643 |
54 | Prolonged bleeding time (HP:0003010) | 2.68502927 |
55 | Hypochromic anemia (HP:0001931) | 2.65082296 |
56 | Arterial thrombosis (HP:0004420) | 2.64469204 |
57 | Autoimmune thrombocytopenia (HP:0001973) | 2.61190157 |
58 | B lymphocytopenia (HP:0010976) | 2.56393723 |
59 | Chronic diarrhea (HP:0002028) | 2.54164733 |
60 | Hypochromic microcytic anemia (HP:0004840) | 2.49017154 |
61 | Pulmonary embolism (HP:0002204) | 2.47062121 |
62 | Lymphopenia (HP:0001888) | 2.46900323 |
63 | Urticaria (HP:0001025) | 2.46709217 |
64 | Anorexia (HP:0002039) | 2.44202463 |
65 | Gangrene (HP:0100758) | 2.43052156 |
66 | Abnormality of the pleura (HP:0002103) | 2.42561706 |
67 | Hypoproteinemia (HP:0003075) | 2.42170054 |
68 | Joint swelling (HP:0001386) | 2.42159841 |
69 | Abnormality of cells of the lymphoid lineage (HP:0012140) | 2.36921845 |
70 | Epistaxis (HP:0000421) | 2.35323436 |
71 | Episodic fever (HP:0001954) | 2.33310173 |
72 | Hypergammaglobulinemia (HP:0010702) | 2.32481537 |
73 | Spontaneous hematomas (HP:0007420) | 2.20663291 |
74 | Absent rod-and cone-mediated responses on ERG (HP:0007688) | 2.17580553 |
75 | Chronic otitis media (HP:0000389) | 2.15780539 |
76 | Inflammation of the large intestine (HP:0002037) | 2.15355681 |
77 | Gingival bleeding (HP:0000225) | 2.14486977 |
78 | Petechiae (HP:0000967) | 2.08501374 |
79 | Sepsis (HP:0100806) | 2.07656484 |
80 | Verrucae (HP:0200043) | 2.07545345 |
81 | Papilloma (HP:0012740) | 2.07545345 |
82 | Gastrointestinal inflammation (HP:0004386) | 2.05910348 |
83 | Pulmonary fibrosis (HP:0002206) | 2.03477778 |
84 | Keratitis (HP:0000491) | 2.02222119 |
85 | Abnormality of male internal genitalia (HP:0000022) | 2.00710014 |
86 | Glomerulopathy (HP:0100820) | 2.00324910 |
87 | Skin rash (HP:0000988) | 1.99960020 |
88 | Aplastic anemia (HP:0001915) | 1.97022789 |
89 | Premature loss of primary teeth (HP:0006323) | 1.93478620 |
90 | Alveolar cell carcinoma (HP:0006519) | 1.93299553 |
91 | Lymphoma (HP:0002665) | 1.90287483 |
92 | Congenital stationary night blindness (HP:0007642) | 1.89473150 |
93 | Gingivitis (HP:0000230) | 1.89456239 |
94 | Cellulitis (HP:0100658) | 1.88554653 |
95 | Vertigo (HP:0002321) | 1.84746098 |
96 | Neutropenia (HP:0001875) | 1.84674159 |
97 | Abnormality of the pericardium (HP:0001697) | 1.83429873 |
98 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.81731760 |
99 | Polyneuropathy (HP:0001271) | 1.80632981 |
100 | Abnormal rod and cone electroretinograms (HP:0008323) | 1.80240943 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TXK | 4.74721292 |
2 | TAOK3 | 4.43295153 |
3 | MAP4K1 | 4.16899004 |
4 | RIPK4 | 3.56651521 |
5 | GRK6 | 3.33168093 |
6 | FES | 3.13507400 |
7 | ITK | 2.23335646 |
8 | KDR | 2.20876036 |
9 | SYK | 2.20788611 |
10 | TNK2 | 2.13377779 |
11 | IRAK4 | 2.12538212 |
12 | CSK | 2.08787253 |
13 | ZAP70 | 2.08290907 |
14 | BTK | 2.07892103 |
15 | TESK2 | 1.97586529 |
16 | BLK | 1.90390957 |
17 | IKBKE | 1.87709511 |
18 | KIT | 1.84676930 |
19 | JAK3 | 1.78714876 |
20 | TEC | 1.73329454 |
21 | MAP2K2 | 1.73130710 |
22 | MAP3K14 | 1.67507372 |
23 | LCK | 1.66997031 |
24 | TYK2 | 1.62151968 |
25 | TBK1 | 1.58289909 |
26 | HCK | 1.55457964 |
27 | IKBKB | 1.54924950 |
28 | LYN | 1.50925717 |
29 | TLK1 | 1.50784165 |
30 | ADRBK2 | 1.46734915 |
31 | FRK | 1.46414635 |
32 | MAP3K13 | 1.36215827 |
33 | ERN1 | 1.27676333 |
34 | BMPR2 | 1.26911882 |
35 | CSF1R | 1.26156083 |
36 | NUAK1 | 1.24475376 |
37 | MAP2K3 | 1.23967750 |
38 | PRKCQ | 1.14567378 |
39 | BCKDK | 1.14376377 |
40 | GRK7 | 1.11384018 |
41 | JAK1 | 1.09355587 |
42 | JAK2 | 0.97529469 |
43 | MAP3K11 | 0.95894411 |
44 | PIM1 | 0.95403405 |
45 | ZAK | 0.95051026 |
46 | MATK | 0.95043148 |
47 | PIK3CG | 0.86123068 |
48 | MARK3 | 0.79449961 |
49 | GRK1 | 0.66211582 |
50 | MUSK | 0.65202848 |
51 | CAMKK2 | 0.64034485 |
52 | FYN | 0.60998139 |
53 | SIK3 | 0.60840466 |
54 | FGR | 0.59834928 |
55 | PIK3CA | 0.59424187 |
56 | EPHB1 | 0.57572847 |
57 | MAP2K6 | 0.57438627 |
58 | STK10 | 0.57079705 |
59 | CAMKK1 | 0.56318038 |
60 | PDK1 | 0.56038152 |
61 | MAP3K7 | 0.55945175 |
62 | MAPK7 | 0.54410883 |
63 | PINK1 | 0.53033672 |
64 | ACVR1B | 0.49965930 |
65 | MAP4K2 | 0.48162310 |
66 | MAP3K3 | 0.47911840 |
67 | SIK2 | 0.46097034 |
68 | PASK | 0.46006021 |
69 | TRPM7 | 0.45700569 |
70 | TAOK1 | 0.43674623 |
71 | IRAK1 | 0.43480769 |
72 | PTK2B | 0.43285410 |
73 | DAPK2 | 0.43015439 |
74 | ADRBK1 | 0.41787740 |
75 | ABL1 | 0.41452377 |
76 | RPS6KA6 | 0.41189476 |
77 | MAPKAPK3 | 0.39564839 |
78 | MAP3K1 | 0.38776014 |
79 | IGF1R | 0.38133489 |
80 | PRKD2 | 0.35424981 |
81 | MAPK12 | 0.35180137 |
82 | NLK | 0.34838617 |
83 | MST4 | 0.32878540 |
84 | PRKCD | 0.32416188 |
85 | VRK2 | 0.31936100 |
86 | MAPKAPK2 | 0.31845809 |
87 | RPS6KL1 | 0.31668658 |
88 | RPS6KC1 | 0.31668658 |
89 | CDK8 | 0.31637981 |
90 | MAPK11 | 0.31458786 |
91 | GRK5 | 0.29484936 |
92 | HIPK2 | 0.29190471 |
93 | MAPK3 | 0.28452159 |
94 | MAPK13 | 0.27289095 |
95 | PRKCH | 0.27249388 |
96 | TGFBR2 | 0.26713165 |
97 | CDK4 | 0.26086918 |
98 | SCYL2 | 0.26008263 |
99 | STK11 | 0.25592338 |
100 | MAP2K1 | 0.25434122 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Primary immunodeficiency_Homo sapiens_hsa05340 | 4.93018768 |
2 | Graft-versus-host disease_Homo sapiens_hsa05332 | 3.62165894 |
3 | Allograft rejection_Homo sapiens_hsa05330 | 3.51528626 |
4 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 3.46470359 |
5 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 2.88152141 |
6 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.77116167 |
7 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 2.64498330 |
8 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 2.56520238 |
9 | Antigen processing and presentation_Homo sapiens_hsa04612 | 2.55316477 |
10 | Leishmaniasis_Homo sapiens_hsa05140 | 2.51171409 |
11 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 2.44453692 |
12 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.38680358 |
13 | Asthma_Homo sapiens_hsa05310 | 2.30009122 |
14 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 2.25275114 |
15 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.20521512 |
16 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 2.16569962 |
17 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.11908249 |
18 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 1.95768909 |
19 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 1.90255659 |
20 | Measles_Homo sapiens_hsa05162 | 1.90240348 |
21 | Viral myocarditis_Homo sapiens_hsa05416 | 1.64696157 |
22 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 1.64479923 |
23 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.56430031 |
24 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.54907976 |
25 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.51706094 |
26 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 1.46024006 |
27 | Malaria_Homo sapiens_hsa05144 | 1.45807309 |
28 | Tuberculosis_Homo sapiens_hsa05152 | 1.42269282 |
29 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 1.41203153 |
30 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.35461961 |
31 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 1.33717904 |
32 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.22799174 |
33 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 1.21307211 |
34 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.08071538 |
35 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.06827321 |
36 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.03285865 |
37 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.02230531 |
38 | Platelet activation_Homo sapiens_hsa04611 | 0.99193360 |
39 | Influenza A_Homo sapiens_hsa05164 | 0.98603189 |
40 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.94595055 |
41 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.88551698 |
42 | Legionellosis_Homo sapiens_hsa05134 | 0.85143127 |
43 | Shigellosis_Homo sapiens_hsa05131 | 0.84176496 |
44 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.76961784 |
45 | Phototransduction_Homo sapiens_hsa04744 | 0.75088250 |
46 | Apoptosis_Homo sapiens_hsa04210 | 0.74163143 |
47 | Pertussis_Homo sapiens_hsa05133 | 0.71633934 |
48 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.71055033 |
49 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.69194371 |
50 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.68691118 |
51 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.67900024 |
52 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.65736968 |
53 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.64378143 |
54 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.63261391 |
55 | Phagosome_Homo sapiens_hsa04145 | 0.62290607 |
56 | Salmonella infection_Homo sapiens_hsa05132 | 0.61344613 |
57 | Hepatitis B_Homo sapiens_hsa05161 | 0.56383299 |
58 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.54279211 |
59 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.51765396 |
60 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.49444860 |
61 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.48252257 |
62 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.47861431 |
63 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.46501770 |
64 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.46095095 |
65 | Hepatitis C_Homo sapiens_hsa05160 | 0.45698636 |
66 | HTLV-I infection_Homo sapiens_hsa05166 | 0.43861420 |
67 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.39024700 |
68 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.38952681 |
69 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.38634090 |
70 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.38234452 |
71 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.36742060 |
72 | Olfactory transduction_Homo sapiens_hsa04740 | 0.33311911 |
73 | Endocytosis_Homo sapiens_hsa04144 | 0.33156850 |
74 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.30608428 |
75 | Homologous recombination_Homo sapiens_hsa03440 | 0.30313077 |
76 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.29609557 |
77 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.29124384 |
78 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.28753602 |
79 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.28461709 |
80 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.28125838 |
81 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.27420419 |
82 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.26837946 |
83 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.26618343 |
84 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.26522011 |
85 | Morphine addiction_Homo sapiens_hsa05032 | 0.25354633 |
86 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.24170359 |
87 | Lysosome_Homo sapiens_hsa04142 | 0.24135989 |
88 | Other glycan degradation_Homo sapiens_hsa00511 | 0.23923473 |
89 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.23608273 |
90 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.23323390 |
91 | Proteasome_Homo sapiens_hsa03050 | 0.19411469 |
92 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.19289236 |
93 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.18688261 |
94 | RNA degradation_Homo sapiens_hsa03018 | 0.16901022 |
95 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.15964274 |
96 | ABC transporters_Homo sapiens_hsa02010 | 0.14138927 |
97 | RNA polymerase_Homo sapiens_hsa03020 | 0.13313312 |
98 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.11791550 |
99 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.11152696 |
100 | Peroxisome_Homo sapiens_hsa04146 | 0.10718062 |